79,250 results match your criteria Connective Tissue Nevus


Mulberry leaf polysaccharides suppress renal fibrosis.

Authors:
Shengjun Wu

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China; Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China. Electronic address:

A mulberry leaf polysaccharide (MLP-1) was prepared and partially characterised, and its anti-renal-fibrosis effects were investigated in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats. MLP-1, with a molecular weight of 2,792,624 Da, consisted of arabinose, glucose, xylose, rhamnose, and mannose in a molar ratio of 1:1.13:2. Read More

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December 2018

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5.

PLoS One 2018 6;13(12):e0207826. Epub 2018 Dec 6.

Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden.

Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis by phage display technique showed that one of them (HAM1) is a classical chymase with a specificity similar to the human mast cell chymase. Read More

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December 2018
2 Reads

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

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December 2018

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

J Biomed Opt 2018 Dec;23(12):1-6

California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. Read More

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December 2018
1 Read

Unexpected photosensitivity - a patient with dermatomyositis and concomitant solar urticaria.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Dept. of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany.

Dermatomyositis (DM) is a connective tissue disease with rare incidence, characterized by progressive muscle weakness and typical cutaneous manifestations. Its pathogenesis is still incompletely understood, but next to genetic predisposition environmental factors seem to be implicated in the development of DM (1). Photosensitivity is one important factor for the onset and exacerbation of DM, which is corroborated by the distribution of the cutaneous features on sun-exposed areas and disease photoaggravation (2,3). Read More

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December 2018

Long-range projections from sparse populations of GABAergic neurons in murine subplate.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Anatomy and Genetics, Parks Road, Oxford.

The murine subplate contains some of the earliest generated populations of neurons in the cerebral cortex, which play an important role in the maturation of cortical inhibition. Here we present multiple lines of evidence, that the subplate itself is only very sparsely populated with GABAergic neurons at postnatal day (P)8. We used three different transgenic mouse lines, each of which labels a subset of GABAergic, ganglionic eminence derived neurons. Read More

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December 2018
8 Reads

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.

Nat Commun 2018 Dec 5;9(1):5178. Epub 2018 Dec 5.

Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University, B23, Avenue Hippocrate 13, 4000, Liege, Belgium.

The development of new lymphatic vessels occurs in many cancerous and inflammatory diseases through the binding of VEGF-C to its receptors, VEGFR-2 and VEGFR-3. The regulation of VEGFR-2/VEGFR-3 heterodimerisation and its downstream signaling in lymphatic endothelial cells (LECs) remain poorly understood. Here, we identify the endocytic receptor, uPARAP, as a partner of VEGFR-2 and VEGFR-3 that regulates their heterodimerisation. Read More

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December 2018

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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December 2018

Functionalization of hyaluronic acid hydrogels with ECM-derived peptides to control myoblast behavior.

Acta Biomater 2018 Nov 30. Epub 2018 Nov 30.

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Dr., West Lafayette, IN, 47907, U.S.A. Electronic address:

Volumetric muscle loss (VML) occurs when skeletal muscle injury is too large for the body to fully self-repair. Typically, fibrotic tissue fills the void, which reduces muscle functionality and limb movement. Although a wide variety of natural and synthetic scaffolds have been studied with the purpose of providing the appropriate structural support, to date no scaffold has significantly restored muscle functionality after VML. Read More

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November 2018
1 Read

Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Rhinology & Endoscopic Skull Base Surgery, UCLA Department of Head & Neck Surgery, Los Angeles, California, USA.

Purpose Of Review: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.

Recent Findings: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Read More

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November 2018

Characterization of thoracal fat depots - expression of adipokines and remodeling factors and impact of adipocyte conditioned media in fibroblast scratch assays.

Clin Hemorheol Microcirc 2018 ;70(3):267-280

Department of Cardiac Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Herzzentrum Dresden, Germany.

Adipose tissue is not only a connective tissue but also an endocrine organ secreting adipokines like Leptin and Adiponectin, lipokines such as palmitoileic acid and extracellular vesicles. These factors and the expression of matrix remodeling enzymes impact surrounding tissues via paracrine effects. The expression of selected secretion factors and the effect of adipocyte conditioned media from four thoracal adipose tissue origins - subcutaneous, perivascular, pericardial and epicardial adipose tissues - in a fibroblast proliferation/wound healing scratch assay model were investigated. Read More

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January 2018

Anther and pollen development in sweet cherry (Prunus avium L.) in relation to winter dormancy.

Protoplasma 2018 Nov 30. Epub 2018 Nov 30.

Centro de Investigación y Tecnología Agroalimentaria de Aragón. Instituto Agroalimentario de Aragón - IA2 (CITA), Universidad de Zaragoza, Av. Montañana 930, 50059, Zaragoza, Spain.

Anther and pollen development is a highly conserved process in angiosperms, but while pollen formation in annual plants occurs in a few days, in temperate woody perennials, it requires several months. How anther and pollen development is framed in terms of seasonality plays a clear part in reproductive success. In this study, seasonal anther and pollen development is characterized in two sweet cherry cultivars over 2 years, paying special attention to the period of dormancy and unveiling the role of starch in this process. Read More

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November 2018

Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival recession defects in dogs.

Clin Oral Investig 2018 Dec 1. Epub 2018 Dec 1.

Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Objectives: The potential additive effect of an enamel matrix derivative (EMD) to a subepithelial connective tissue graft (CTG) for recession coverage is still controversially discussed. Therefore, the aim of this study was to histologically evaluate the healing of gingival recessions treated with coronally advanced flap (CAF) and CTG with or without EMD in dogs.

Materials And Methods: Gingival recession defects (5 mm wide and 7 mm deep) were surgically created on the labial side of bilateral maxillary canines in 7 dogs. Read More

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December 2018

Optical Rehabilitation of a Patient with Keratoconus and Nystagmus.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):183-189

Kentucky College of Optometry, University of Pikeville, Pikeville, KY, USA.

Keratoconus is a progressive corneal disease characterized by bilateral yet usually asymmetric thinning of the cornea with an onset typically in teenage years. While it often presents as an isolated condition, keratoconus may also be associated with many systemic and/or ocular diseases, such as connective tissue and chromosomal disorders. Its association with nystagmus has been described in Leber's congenital amaurosis, where patients also exhibit abnormal pupillary responses, early-onset retinal dystrophy, mental developmental delays, and eventual blindness. Read More

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January 2018
1 Read

IVD Development: Nucleus pulposus development and sclerotome specification.

Curr Mol Biol Rep 2018 Sep 13;4(3):132-141. Epub 2018 Jul 13.

University of Alabama at Birmingham.

Purpose Of Review: Intervertebral discs (IVD) are derived from embryonic notochord and sclerotome. The nucleus pulposus is derived from notochord while other connective tissues of the spine are derived from sclerotome. This manuscript will review the past 5 years of research into IVD development. Read More

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September 2018

Functioning in the emotional sphere and ways of coping with chronic connective tissue disease.

Reumatologia 2018 31;56(5):321-327. Epub 2018 Oct 31.

Department of Integrated Medical Care, Medical University of Białystok, Poland.

Chronic illness is a strong stressor, and its occurrence in human life forces the individual to make adaptive changes. The aim of the study was to evaluate the reactions, behaviors, and emotional states of a person in the face of systemic connective tissue disease and ways of coping with this difficult situation. The method of choice was an individual case study. Read More

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October 2018

Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.

Reumatologia 2018 31;56(5):307-315. Epub 2018 Oct 31.

Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.

Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common conditions from which to differentiate in rheumatological care. Read More

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October 2018

Morphology of the lingual papillae of the lion-tailed macaque.

Authors:
Shoichi Emura

Okajimas Folia Anat Jpn 2018 ;95(2):33-36

Heisei College of Health Sciences.

We microscopically examined the dorsal lingual surface of an adult lion-tailed macaque (Macaca silenus). The tongue of the chimpanzee was about 13 cm long. Filiform papillae on the lingual apex consisted of several pointed processes. Read More

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January 2018

Morphology of the lingual papillae in the leopard.

Authors:
Shoichi Emura

Okajimas Folia Anat Jpn 2018 ;95(2):29-32

Heisei College of Health Sciences.

We microscopically examined the dorsal lingual surface of an old leopard (Panthera pardus). The filiform papillae on the lingual apex were dome-shaped. The connective tissue cores of the filiform papillae resembled a well in shape, while those of the fungiform papillae were not hollow. Read More

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January 2018

Statins and Mortality in Connective Tissue Diseases: Should We Resume the Cardio-rheumatology Spirit in Our Clinics?

J Rheumatol 2018 Dec;45(12):1617-1619

Institute of Rheumatology and Postgraduate School in Rheumatology, IRCCS Fondazione Policlinico Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

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December 2018

Serological Assessment of Activated Fibroblasts by alpha-Smooth Muscle Actin (α-SMA): A Noninvasive Biomarker of Activated Fibroblasts in Lung Disorders.

Transl Oncol 2018 Nov 29;12(2):368-374. Epub 2018 Nov 29.

Nordic Bioscience A/S, Herlev, Denmark.

Objectives: Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon activation. All myofibroblasts express α-SMA, which has been found to be upregulated in lung fibrosis and cancer. Read More

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November 2018

Review of Management Options for Active-Phase Peyronie's Disease.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

Introduction: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Read More

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November 2018

Langerhans cell histiocytosis of the skull in the burr-hole site covered with hydroxyapatite material: a case report.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, Ebina General Hospital, Kanagawa, Japan.

Background: We present a case report of a male patient with Langerhans cell histiocytosis (LCH), which occurred in a burr-hole site for chronic subdural hematoma covered with hydroxyapatite material. LCH is a rare dendritic histiocytic disorder that affects the bones, especially the skull. Until now, the association with foreign-body reaction has rarely been reported by any author. Read More

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November 2018
2 Reads

Increased cardiovascular comorbidities in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia presenting with systemic inflammatory and autoimmune manifestations.

Semin Hematol 2018 Oct 28;55(4):242-247. Epub 2018 May 28.

Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland; Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Myelodysplastic syndromes (MDS) and associated diseases, like chronic myelomonocytic leukemias (CMML), are heterogeneous, clonal disorders affecting the hematopoietic stem cells. They are characterized by dysplasia and a propensity to evolve toward acute myeloid leukemia. Systemic inflammatory and autoimmune manifestations (SIAMs) occur with a prevalence of 10% to 20% in myeloid malignancies, but the underlying pathogenetic mechanisms remain obscure. Read More

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October 2018

Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes.

Med Sci (Basel) 2018 Nov 29;6(4). Epub 2018 Nov 29.

Instituto de Investigación, Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, 28006 Madrid, Spain.

Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is characterized by a chronic, progressive, fibrotic interstitial lung disease of unknown cause that occurs primarily in older adults. Its prevalence and incidence have appeared to be increasing over the last decades. Read More

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November 2018

Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging.

Cells 2018 Nov 29;7(12). Epub 2018 Nov 29.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB), Friedrich Schiller University Jena, Hans-Knöll-Str. 2, 07745 Jena, Germany.

In complex organisms, stem cells are key for tissue maintenance and regeneration. Adult stem cells replenish continuously dividing tissues of the epithelial and connective types, whereas in non-growing muscle and nervous tissues, they are mainly activated upon injury or stress. In addition to replacing deteriorated cells, adult stem cells have to prevent their exhaustion by self-renewal. Read More

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November 2018

A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts.

J Periodontol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dental Diagnostic and Surgical Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.

Background: The purpose was to compare patient-centered outcomes, early wound healing and post-operative complications at palatal donor area of subepithelial connective tissue grafts (CTG) between cyanoacrylates tissue adhesives and Polytetrafluoroethylene (PTFE) sutures.

Methods: 36 patients who required harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two groups. In the "suture" group, wound closure was achieved with standardized continuous interlocking 6-0 PTFE sutures, while in the "cyanoacrylate" group, a high viscosity blend of n-butyl and 2-octyl cyanoacrylate was applied until hemostasis was achieved. Read More

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December 2018
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Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy.

J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai.

Context: Unique features of local immunity in thyroid-associated ophthalmopathy (TAO) may affect disease progression.

Objective: To investigate the association between the orbital immune microenvironment and TAO development.

Design/setting/participants: TAO and control orbital connective tissues were collected. Read More

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December 2018
1 Read

Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study.

Braz Dent J 2018 Sep-Oct;29(5):435-445

Universidade Positivo, Curitiba, PR, Brazil.

This study aimed to evaluate the effect of two methods of local application of alendronate and parathyroid hormone (PTH) on bone repair and the systemic implications. A critically sized defect (5 mm) was created in the cranial region of twenty-five male Wistar rats, and the bone removed was particulated, and grafted back to the defect with different treatments. The animals were randomly divided into five groups: A1- bone graft immersion in alendronate solution (3 mg/kg) for 5 minutes; P1- bone graft immersion in PTH solution (20 µg); A2- weekly local applications of alendronate 1 mg/kg; P2- weekly local applications of PTH (20 µg); C- no drugs were used. Read More

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Ultrasonography features of abdominal perimuscular connective tissue in elite and amateur basketball players: an observational study.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):936-941

Nursing and Physical Therapy Department, Faculty of Health Sciences, Universidad de León, Ponferrada, Spain.

The purpose of this study was to assess and compare with rehabilitative ultrasound imaging (RUSI) the perimuscular connective tissue (PMCT) and interrecti distance (IRD) between elite and amateur basketball players. A sample of 22 healthy basketball players was included and divided into two groups: elite basketball players from Spanish 1st division (n = 11) and amateur basketball players from an entertainment Spanish division (n = 11). Ultrasound images of the external oblique (EO), internal oblique (IO), transversus abdominis (TrAb), rectus anterior (RA) and IRD PMCT were measured and analysed by the ImageJ software. Read More

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October 2018

EFFECTIVENESS OF NONALCOHOLIC STEATOHEPATITIS CORRECTION ON THE BAСKGROUND OF OBESITY WITH CONCOMITANT CHRONIC KIDNEY DISEASE.

Georgian Med News 2018 Oct(283):76-80

Higher educational establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The article presents a theoretical generalization of the research results the effectiveness of heparisin on the state of the carbohydrate-protein components of the extracellular matrix of connective tissue in liver in patients with non-alcoholic steatohepatitis with obesity I-II degree and chronic kidney disease І-ІІ stage. The purpose of the study is to find out the effectiveness of heparisin (glycyrizine 40 mg, glycine 400 mg, L-cysteine hydrochloride 20 mg) on the state of the carbohydrate-protein components of the extracellular matrix in connective tissue of the liver in patients with non-alcoholic steatohepatitis (NASH) with obesity I-II degree and chronic kidney disease (CKD) І-ІІ stage. 98 patients with NASH on the background of obesity of the I-II degree were examined, including: 52 patients with NASH (I group) (without accompanying CKD), 46 patients with NASH with comorbid CKD І-ІІ stage (II group). Read More

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October 2018

IMPROVEMENT OF THE DERMATENSION METHOD IN THE RECONSTRUCTIVE-RECOVERY SURGERY OF DEFECTS OF SOFT TISSUES OF VARIOUS ETIOLOGY.

Georgian Med News 2018 Oct(283):7-10

Kharkov Medical Academy of Postgraduate Education, Ukraine.

The problem of treating patients with loss of the skin and with a complicated course of the wound process remains topical. The problem is that, despite the relative technical simplicity of the dermatension method, the most significant complication is the decubitus of the stretchable flap, which is associated with a relatively high incidence of acute blood circulatory disturbances in the stretch tissues due to vascular compression with an excessive amount of injected fluid. The aim of the work is to improve the method of dermatension in reconstructive and recovery surgery of soft tissue defects of various genesis by planning and implementing dermatension at all its steps with instrumental control of the process using ultrasound and ICT in a complex. Read More

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October 2018
2 Reads

Proteomics of Uterosacral Ligament Connective Tissue from Women With and Without Pelvic Organ Prolapse.

Proteomics Clin Appl 2018 Dec 5:e1800086. Epub 2018 Dec 5.

The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Hangzhou, China.

Purpose: Damage to the uterosacral ligaments is an important contributor to uterine and vaginal prolapse. The aim of this study was to identify differentially expressed proteins in the uterosacral ligaments of women with and without pelvic organ prolapse and analyze their relationships to cellular mechanisms involved in the pathogenesis of pelvic organ prolapse.

Experimental Design: Uterosacral ligament connective tissue from four patients with pelvic organ prolapse and four control women underwent iTRAQ analysis followed by Ingenuity Pathway Analysis of differentially expressed proteins. Read More

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December 2018

Immunomodulatory properties of mesenchymal stromal cells: still unresolved "Yin and Yang".

Curr Stem Cell Res Ther 2018 Dec 4. Epub 2018 Dec 4.

Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Milan. Italy.

Mesenchymal stromal cells (MSC) are mesodermal elements characterized by the ability to differentiate into several types of cells present mainly in connective tissues. They play a key function in tissue homeostasis and repair. Furthermore, they exert a strong effect on both innate and adaptive immune response. Read More

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December 2018
2 Reads

Effects of dipeptidyl peptidase-4 inhibitors on transforming growth factor-β1 signal transduction pathways in the ovarian fibrosis of polycystic ovary syndrome rats.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Gynecology, The Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, Zhejiang, China.

Aim: Examine the effects of dipeptidyl peptidase-4 (DPP4) inhibitor Sitagliptin on the transforming growth factor-β1 (TGF-β1) signal transduction pathway in polycystic ovary syndrome (PCOS) rats with ovarian fibrosis.

Methods: Thirty rats were divided randomly into the PCOS model group, Sitagliptin treatment group and blank control group. Dehydroepiandrosterone was administered to the model group and treatment group to establish the models. Read More

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December 2018

On the median pharyngeal valve of the American alligator (Alligator mississippiensis).

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, University of Maryland, College Park, Maryland.

The middle ear cavities of crocodilians have complex connections with the pharyngeal lumen, including lateral and median components which both open into a single chamber located on the dorsal midline of the pharynx. This chamber and the surrounding soft-tissue is herein termed the median pharyngeal valve. In the American alligator (Alligator mississippiensis) this valve opens, for a duration of 0. Read More

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December 2018
2 Reads

Biocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, Bio-C Pulpo.

Int Endod J 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinics and Surgery, School of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG.

Aim: To evaluate the inflammatory response and ability to induce mineral deposition through histological and immunohistochemical analysis for osteocalcin (OCN), osteopontin (OPN), and bone sialoprotein (BSP) of a new calcium silicate-based cement, Bio-C Pulpo (Angelus), compared to white mineral trioxide aggregate (White MTA-Ang) (Angelus).

Methodology: Polyethylene tubes containing Bio-C Pulpo and White MTA-Ang as well as empty tubes were implanted into the dorsal connective tissue of 30 Wistar rats, which were arranged in 5 groups according to the period of analysis: 7, 15, 30, 60, and 90 days. After each experimental period, the tubes with surrounding tissue were removed and histologically processed to be analysed using haematoxylin-eosin and immunohistochemistry for the detection of OCN, OPN, and BSP. Read More

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December 2018

IL-9 Integrates the Host- Cross-Talk in Vulvovaginal Candidiasis to Balance Inflammation and Tolerance.

Front Immunol 2018 20;9:2702. Epub 2018 Nov 20.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

Vulvovaginal candidiasis (VVC) is a common fungal infection caused by . The antifungal therapy represents the standard of care but due to the high costs of treatment and to the inability to prevent recurrences, the development of alternative therapeutic approaches is much-awaited. Recently, we have shown that the pathogenesis of in the gut is modulated by IL-9, a pleiotropic cytokine able to promote both inflammation and tolerance during infection. Read More

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November 2018

Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study.

Arthritis Res Ther 2018 Dec 4;20(1):267. Epub 2018 Dec 4.

Joint Rheumatology Program, 1st Department of Propedeutic Internal Medicine-Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece.

Background: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). Read More

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December 2018
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Blood⁻Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne's Thread in Labyrinths of Hypotheses.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Department of Human and Animal Physiology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.

The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. Read More

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November 2018
1 Read

Hyperlaxité articulaire : quand évoquer un syndrome d’Ehlers-Danlos ?

Rev Prat 2016 Apr;66(4):423-429

Centre de référence de la maladie de Fabry et des pathologies héréditaires du tissu conjonctif, service de génétique médicale, université de Versailles-Saint- Quentin-en-Yvelines, université Paris-Saclay, Montigny, France.

Joint hypermobility: when to evoke Ehlers-Danlos syndrome? Variable with age, gender and ethnicity, joint hyperlaxity refers to an increased capacity of extension or flexion of the joints beyond normal limits. The Beighton score is used to confirm or exclude hyperlaxity. While a Beighton score under 5 should not always lead to exclude the diagnosis of Ehlers-Danlos syndrome (EDS), a positive scoring of 5 or more (generalized joint hypermobility) is usually required in adults to consider the diagnosis. Read More

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[Key anatomies of DeLancey's three levels of vaginal support theory: an observation in laparoscopic surgery].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):329-337

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To observe and verify the key anatomies of DeLancey's three levels of vaginal support theory through laparoscopic surgery by space dissection technique.

Methods: The features and stress performance of related anatomies were observed and analyzed in laparoscopic type C hysterectomy and pelvic lymphadenectomy for cervical cancer by natural space exposures.

Results: The main ligament-like structure at level Ⅰ was the uterosacral ligament, which acted as the main apical fixation in the sacral direction, while the cardinal ligament was mainly composed of vascular system, lymph-vessels and loose connective tissue around them, lacking the tough connective tissue structures, which was connected to the internal iliac vascular system. Read More

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February 2018

Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation.

J Periodontal Res 2018 Dec 3. Epub 2018 Dec 3.

Division of Tissue Engineering and Biophotonics, Dental Institute, King's College London, London, UK.

Objectives: The inhibitory action of the superficial gingival connective tissues may limit the regenerative potential of alveolar bone in periodontal therapy or dental implant applications. The aims of this study were to investigate the hypothesis that gingival fibroblasts (GF) can inhibit bone morphogenetic protein (BMP)-induced osteoblastic differentiation, to determine their expression of BMP inhibitors, and finally to determine whether reduction of these inhibitors can relieve suppression of osteoblastic differentiation.

Methods: Gingival fibroblasts were co-cultured either directly or indirectly with calvarial osteoblasts to assess alkaline phosphatase inhibitory activity, a marker of osteoblastic differentiation. Read More

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December 2018
2 Reads

Enhancement of wound healing by single-wall/multi-wall carbon nanotubes complexed with chitosan.

Int J Nanomedicine 2018 8;13:7195-7206. Epub 2018 Nov 8.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine,

Background: Impaired wound healing is commonly associated with many health problems, including diabetes, bedsores and extensive burns. In such cases, healing often takes a long time, which subjects patients to various complications. This study aims to investigate whether single-wall or multi-wall carbon nanotubes complexed with chitosan hydrogel can improve wound healing. Read More

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November 2018

Diagnostic histochemistry in non-neoplastic skin diseases.

Semin Diagn Pathol 2018 Nov 16;35(6):390-398. Epub 2018 Oct 16.

PRW Laboratories, Charlottesville, VA, USA.

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. Read More

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November 2018
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Mesalazine-related lung disease in a patient with ulcerative colitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13242

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital.

Rationale: Mesalazine is widely used to treat inflammatory bowel disease (IBD). However, discriminating between pulmonary manifestations of IBD and drug-related lung disease remains a challenge. There were few case reports of mesalazine-related organizing pneumonia so far. Read More

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November 2018
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Screening of hydrogel-based scaffolds for dental pulp regeneration-A systematic review.

Arch Oral Biol 2018 Nov 22;98:182-194. Epub 2018 Nov 22.

Post Graduation Program, School of Dentistry, Ibirapuera University, Brazil. Electronic address:

Objective: The aim of this systematic review was to evaluate the most appropriate hydrogel scaffold type (natural, synthetic or hybrid) to be applied with stem cells for dental pulp regeneration. The findings should help clinicians make an informed choice about the appropriate scaffold to be applied for this approach.

Design: Three electronic databases were searched (Medline, Web of Science and Scopus). Read More

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November 2018
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Structures of filum terminale and characteristics of ependymal cells of its central canal in rats.

Brain Res 2018 Nov 27. Epub 2018 Nov 27.

Central Biomedical Laboratory, Aino University School of Health Science, 4-5-11 Higashiohda, Ibaraki City, Osaka 567-0012, Japan. Electronic address:

The filum terminale (FT) is a potential source of ependymal cells for transplantation. The present study was performed to clarify the characteristics of ependymal cells of the central canal (CC) of the FT in rats. The FT was a thin strand continuous with the conus medullaris (CM), a caudal end of the main spinal cord, situated at the L3-4 level in adult rats. Read More

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November 2018
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