80,974 results match your criteria Connecticut medicine[Journal]
Cannabis Cannabinoid Res 2018 10;3(1):252-258. Epub 2018 Dec 10.
Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, Texas.
Org27569 is a prototypical allosteric modulator of the cannabinoid receptor 1 (CB). It belongs to the indole-2-carboxamide scaffold and has been intensively investigated in pharmacology and in structure-activity relationship (SAR) studies. Although azaindoles are rare in natural products and differ only by the presence of an extra ring nitrogen, they were demonstrated as valuable bioisosteres in many pharmacologically important molecules. Read More
Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.
University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.
Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More
Clin Epigenetics 2018 Dec 13;10(1):155. Epub 2018 Dec 13.
Department of Psychiatry, Yale School of Medicine, 300 George Street, 950 Campbell Ave, West Haven, New Haven, CT, 06511, USA.
Background: The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their immune-related outcomes, including frailty and mortality. The application of a machine learning approach to the analysis of CpG methylation in the epigenome enables the selection of phenotypically relevant features from high-dimensional data. Using this approach, we now report that a set of smoking-associated DNA-methylated CpGs predicts HIV prognosis and mortality in an HIV-positive veteran population. Read More
Proteomes 2018 Dec 9;6(4). Epub 2018 Dec 9.
Yale/NIDA Neuroproteomics Center, 300 George St., New Haven, CT 06511, USA.
Cell-type-specific analysis has become a major focus for many investigators in the field of neuroscience, particularly because of the large number of different cell populations found in brain tissue that play roles in a variety of developmental and behavioral disorders. However, isolation of these specific cell types can be challenging due to their nonuniformity and complex projections to different brain regions. Moreover, many analytical techniques used for protein detection and quantitation remain insensitive to the low amounts of protein extracted from specific cell populations. Read More
Antioxidants (Basel) 2018 Dec 8;7(12). Epub 2018 Dec 8.
Food and therapeutic alternatives area, Ophidism Program, School of Microbiology, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. Read More
J Knee Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Orthopedic Surgery, New England Baptist Hospital, Boston, Massachusetts.
While femoral intramedullary alignment has been found to be the most accurate and reproducible method for proper femoral component orientation in total knee arthroplasty, certain situations preclude the use of intramedullary alignment, such as ipsilateral long-stem total hip arthroplasty, femoral shaft deformity (congenital or post-traumatic), capacious femoral canal, and retained hardware. These cases require alternative alignment guides, that is, extramedullary alignment. The purpose of this study was to determine the accuracy of intramedullary alignment in reproducing the femoral anatomic axis. Read More
J Infect Dis 2018 Dec 13. Epub 2018 Dec 13.
Johns Hopkins University, Baltimore, Maryland, USA.
Background: While the 2015-2016 Zika epidemics prompted accelerated vaccine development, decision makers need to know the potential economic value of vaccination strategies.
Methods: We developed models of Honduras, Brazil, and Puerto Rico, simulated targeting different populations for Zika vaccination (women of childbearing age, school-aged children, young adults, and everyone) and then introduced various Zika outbreaks. Sensitivity analyses varied vaccine characteristics. Read More
PLoS One 2018 13;13(12):e0209084. Epub 2018 Dec 13.
Department of Psychology, University of Oslo, Oslo, Norway.
It is well-established that experiences of discrimination influence immigrants' acculturation. Yet, whereas a large body of research has demonstrated the role of discrimination by members of the dominant societal group, surprisingly little is known about how being discriminated by members of one's own group relates to the way immigrants acculturate. With a sample of 162 African first- and second-generation immigrants living in Norway, the present research investigated the relationship between both types of discrimination, acculturation and psychological well-being. Read More
Cancer Nurs 2018 Dec 12. Epub 2018 Dec 12.
Author Affiliations: Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville (Drs Lynch Kelly, Alexander-Delpech, Lyon, Siangphoe, and Yang); School of Nursing (Dr. Starkweather), University of Connecticut, Storrs.
Background: With a nearly 89% 5-year survival rate for women with early-stage breast cancer, symptoms are a priority. Healthy lifestyle behaviors may be temporally associated with symptoms; however, evidence is lacking.
Objective: This research examined temporal relationships among healthy lifestyle behaviors and symptoms in women diagnosed with breast cancer receiving chemotherapy. Read More
Curr Opin Anaesthesiol 2018 Dec 12. Epub 2018 Dec 12.
Department of Anesthesiology, Yale School of Medicine & VA Connecticut Healthcare System, New Haven, Connecticut, USA.
Am J Respir Crit Care Med 2018 Dec 13. Epub 2018 Dec 13.
Yale University, Pulmonary and Critical Care Medicine, New Haven, Connecticut, United States ;
Bioconjug Chem 2018 Dec 13. Epub 2018 Dec 13.
Medicine Design , Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States.
A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and via biophysical characterization of DNA binding), chemical tractability, and in vitro and in vivo stability of the compounds in this class eliminated a number of potential candidates, greatly reducing the complexity and resources required for conjugate preparation and evaluation. This effort yielded a potent, stable, and efficacious ADC, PF-06888667, consisting of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline- p-aminobenzyl alcohol- N, N-dimethylethylenediamine (AcLysValCit-PABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase. Read More
Mucosal Immunol 2018 Dec 12. Epub 2018 Dec 12.
Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer's patches maturation, represented by IFNγ-expressing Th1 cells. However, direct mucosal evidence is lacking. Read More
mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.
Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More
Iran J Basic Med Sci 2018 Sep;21(9):911-919
Department of Kinesiology, College of Agriculture, Health and Natural Resources, University of Connecticut, Connecticut, USA.
Objectives: This study aimed to investigate the effect of aerobic training on serum levels of Klotho, cardiac tissue levels of HO and phosphorylation of ERK1/2 and P38 as well as left ventricular internal diameter (LVID), the left ventricle wall thickness (LVWT) and fibrosis in middle-aged rats.
Materials And Methods: Forty wistar rats, including young rats (n=10, 4 month-old) and middle-aged rats (n=30, 13-15 months-old) were enrolled in this experimental study. The all young and 10 middle-aged rats were sacrificed (randomly) under deep anesthesia without any exercise training as normal young control and normal middle-aged control respectively. Read More
Phys Med Biol 2018 Dec 4. Epub 2018 Dec 4.
Department of Radiation Physics, M D Anderson Cancer Center, Box 547, 1515 Holcombe Blvd, Houston, TX 77030, USA, Houston, 77030, UNITED STATES.
In charged particle therapy, the objective is to exploit both the physical and radiobiological advantages of charged particles to improve the therapeutic index. Use of the beam scanning technique provides the flexibility to implement biological dose optimized intensity-modulated ion therapy (IMIT). An easy-to-implement algorithm was developed in the current study to rapidly generate a uniform biological dose distribution, namely the product of physical dose and the relative biological effectiveness (RBE), within the target volume using scanned ion beams for charged particle radiobiological studies. Read More
J Biol Chem 2018 Dec 6. Epub 2018 Dec 6.
Dept. of Cell Biology, University of Connecticut Health Center, United States.
Myocyte enhancer factor 2 (MEF2) transcription factors are key regulators of the development and adult phenotype of diverse tissues including skeletal and cardiac muscles. Controlled by multiple post-translational modifications, MEF2D is an effector for the Ca2+/calmodulin-dependent protein phosphatase calcineurin (CaN, PP2B, and PPP3). CaN-catalyzed dephosphorylation promotes the desumoylation and acetylation of MEF2D increasing its transcriptional activity. Read More
Healthc (Amst) 2018 Dec 3. Epub 2018 Dec 3.
Implementing The Lancet Commission in Global Surgery in India (i-LCoGS), India; WHO Collaborating Centre for Research in Surgical Care Delivery in LMICs, BARC Hospital, Mumbai400094,India.
J Acoust Soc Am 2018 Nov;144(5):EL392
MARCS Institute, Western Sydney University, Sydney, New South Wales, Australia
When using ultrasound imaging of the tongue for speech recording/research, submental transducer stabilization is required to prevent the ultrasound transducer from translating or rotating in relation to the tongue. An iterative prototype of a lightweight three-dimensional-printable wearable ultrasound transducer stabilization system that allows flexible jaw motion and free head movement is presented. The system is completely non-metallic, eliminating interference with co-recorded signals, thus permitting co-collection and co-registration with articulometry systems. Read More
J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.
Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.
Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. Read More
JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.
Elite Sports Medicine, Division of Orthopedic Surgery, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Farmington, Connecticut.
Case: A 14-year-old adolescent with bilateral discoid menisci who had previously undergone discoid meniscal saucerization presented with pain and mechanical knee symptoms bilaterally. She had a torn left discoid lateral meniscus, a right lateral meniscal deficiency with an associated osteochondral defect, and valgus collapse of the right femur. She underwent successful repair of the left discoid meniscus as well as a femoral osteotomy, a meniscal transplant, and an osteochondral allograft transplantation in the right knee. Read More
JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.
Department of Orthopaedic Surgery, Northwell Health, Huntington Hospital, Huntington, New York.
Case: Isolated patella absentia is an extremely rare phenomenon, with only a few published cases and even fewer follow-up reports. Nearly 40 years after the initial presentation of 2 brothers with bilateral congenital absence of the patella and the publication of a case report, we report the clinical and radiographic findings of their subsequent tibiofemoral osteoarthritis, which was treated with bilateral total knee arthroplasty.
Conclusion: Understanding the biomechanical complications associated with congenital absence of the patella as it relates to a stable knee is vital; in the case of degenerative changes, total knee arthroplasty appears to provide a long-term solution for these patients. Read More
Biochemistry 2018 Dec 12. Epub 2018 Dec 12.
Department of Cellular and Molecular Physiology , Yale University School of Medicine , P.O. Box 208026, New Haven , Connecticut 06520-8026 , United States.
Mol Psychiatry 2018 Dec 11. Epub 2018 Dec 11.
Department of Psychology, University of Connecticut, Storrs, CT, USA.
Dimensions of irritability and defiant behavior, though correlated within the structure of ODD, convey separable developmental risks through adolescence and adulthood. Irritability predicts depression and anxiety, whereas defiant behavior is a precursor to antisocial outcomes. Previously we demonstrated that a bifactor model comprising irritability and defiant behavior dimensions, in addition to a general factor, provided the best-fitting structure of ODD symptoms in five large datasets. Read More
Sci Rep 2018 Dec 12;8(1):17898. Epub 2018 Dec 12.
Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut, 06511, USA.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More
Pediatrics 2018 Dec 11. Epub 2018 Dec 11.
Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Background And Objectives: Neonatal tracheal intubation is a critical but potentially dangerous procedure. We sought to characterize intubation practice and outcomes in the NICU and delivery room (DR) settings and to identify potentially modifiable factors to improve neonatal intubation safety.
Methods: We developed the National Emergency Airway Registry for Neonates and collected standardized data for patients, providers, practices, and outcomes of neonatal intubation. Read More
Appl Netw Sci 2017 19;2(1). Epub 2017 Jan 19.
Department of Mathematics, Trinity College, 300 Summit St., 06106, West Hartford, Connecticut, USA.
Today's colleges and universities consist of highly complex structures that dictate interactions between the administration, faculty, and student body. These structures can play a role in dictating the efficiency of policy enacted by the administration and determine the effect that curriculum changes in one department have on other departments. Despite the fact that the features of these complex structures have a strong impact on the institutions, they remain by-and-large unknown in many cases. Read More
Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.
Myongji University - Natural Science Campus, Yongin, 449-728, Korea (the Republic of).
The structure, magnetic and ferroelectric properties of sputtered epitaxial CoFe2O4-BiFeO3 (CFO-BFO) nanocomposite thin films grown on La0.7Sr0.3MnO3 (LSMO) layers on (001) oriented SrTiO3 (STO) substrates and on STO-buffered Si are described. Read More
Addiction 2019 Jan;114(1):137-138
Department of Psychological Sciences, University of Connecticut, USA.
Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.
Department of Pediatrics, Division of Cardiology, UCLA Mattel Children's Hospital, Los Angeles, California.
Objectives: To describe a multi-center experience of percutaneous transcatheter pulmonary valve replacement (TPVR) using the Edwards Sapien S3 Valve.
Background: Off-label use of the Sapien S3 valve can allow for TPVR in patients with congenital heart disease (CHD) and large diameter dysfunctional right ventricular outflow tract (RVOT). The initial experience at five centers with the SAPIEN S3 valve for TPVR is presented with a focus on procedural techniques, success, complications, and efficacy. Read More
Birth Defects Res 2018 Dec 10. Epub 2018 Dec 10.
Department of Linguistics, University of British Columbia, Vancouver, Canada.
The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studies, which focus on central pattern generators and development in model organisms. However, findings suggest that further research is necessary to determine which components of these systems support these behaviors. Read More
Am J Addict 2018 Dec 11. Epub 2018 Dec 11.
The Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Background And Objectives: Neuroactive steroids (NAS) may play a role in addiction, with observed increases in response to acute stress and drug use, but decreases with chronic substance use, suggesting that NAS neuroadaptations may occur with chronic substance use. However, levels of NAS in addicted individuals have not been systematically examined. Here, we evaluated a panel of NAS in men and women with cocaine use disorder (CUD) who participated in a clinical laboratory study of progesterone. Read More
J Am Geriatr Soc 2018 Dec 8. Epub 2018 Dec 8.
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Objectives: To address the competing risk of death in longitudinal studies of older persons, we demonstrate sensitivity analyses that evaluate robustness of associations between exposures and three outcome types: dichotomous, count, and time to event.
Design: A secondary analysis of data from a prospective cohort study.
Setting: Community-based data from the Precipitating Events Project in New Haven, CT. Read More
Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.
Indiana University School of Medicine, Dept. of Biochemistry and Molecular Biology, 635 Barnhill Drive, MS4063, Indianapolis, Indiana.
Ting-Kai (T-K) Li, MD died on November 18, 2018, just five days after his 84 birthday. T-K had a wonderful and distinguished academic and public service career, spanning almost five decades. Born in Nanjing, China, T-K fled with his family to South Africa during World War II, while a young boy. Read More
J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.
Global Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, PA, USA.
Population pharmacokinetics (PK) and exposure-response (E-R) analyses were conducted to compare the PK and E-R relationships of golimumab between children and adults with ulcerative colitis. PK data following subcutaneous golimumab administration to children with ulcerative colitis (6-17 years) in the PURSUIT-PEDS-PK study, adults with ulcerative colitis in the PURSUIT study, and children with pediatric polyarticular juvenile idiopathic arthritis (2-17 years) in the GO-KIDS study, were included in the population PK analysis. E-R analysis was conducted using logistic regression to link serum golimumab concentration and Mayo score-based efficacy outcomes in pediatric and adult ulcerative colitis. Read More
Nurs Forum 2018 Dec 9. Epub 2018 Dec 9.
Center of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI.
Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. Read More
Arch Orthop Trauma Surg 2018 Dec 10. Epub 2018 Dec 10.
Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Introduction: Avulsions of the lesser femoral trochanter are rare injuries in the adolescent population. An acute avulsion causes severe functional impairment with compromised hip flexion. Recent literature reports the superiority of surgical treatment for apophyseal avulsion fractures of the pelvis in adolescents. Read More
Hum Mol Genet 2018 Dec 10. Epub 2018 Dec 10.
Hunter James Kelly Research Institute.
Myelin sheath thickness is precisely regulated and essential for rapid propagation of action potentials along myelinated axons. In the peripheral nervous system, extrinsic signals from the axonal protein neuregulin 1 type III regulate Schwann cell fate and myelination. Here we ask if modulating neuregulin 1 type III levels in neurons would restore myelination in a model of congenital hypomyelinating neuropathy (CHN). Read More
JAMA Intern Med 2018 Dec 10. Epub 2018 Dec 10.
Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut.
J Pediatric Infect Dis Soc 2018 Dec 10. Epub 2018 Dec 10.
Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts.
In 4292 infants aged ≤60 days with cerebrospinal fluid (CSF) pleocytosis, the bacterial meningitis score had excellent sensitivity (121 of 121 [100.0%] [95% confidence interval, 96.5%-100. Read More
JAMA 2018 12;320(22):2377
School of Dentistry, University of Washington, Seattle.
JAMA Intern Med 2018 Dec 10. Epub 2018 Dec 10.
Bridgeport Hospital, Yale New Haven Health System, Bridgeport, Connecticut.
J Gerontol A Biol Sci Med Sci 2018 Dec 8. Epub 2018 Dec 8.
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
NPJ Microgravity 2018 4;4:26. Epub 2018 Dec 4.
1School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, Guangdong China.
Outer space is a challenging environment for all forms of life, and dormant spores of bacteria have been frequently used to study the survival of terrestrial life in a space journey. Previous work showed that outer space vacuum alone can kill bacterial spores. However, the responses and mechanisms of resistance of individual spores to space vacuum are unclear. Read More
Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1840. Epub 2018 Oct 2.
Department of Plastic Surgery, Yale University, Cedar Street, New Haven, Conn.
Background: Telemedicine is a rapidly growing tool since its invention in the 1950s. Recently, it has expanded to the field of plastic surgery. In the Connecticut VA System, there is 1 plastic surgeon at a central location for the state of Connecticut and southern Massachusetts. Read More
Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.
Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
For their food source, Trachymyrmex septentrionalis ants raise symbiotic fungus gardens that contain bacteria whose functions are poorly understood. Here, we report the genome sequences of eight bacteria isolated from these fungus gardens to better describe the ecology of these strains and their potential to produce secondary metabolites in this niche. Read More
Microbiol Resour Announc 2018 Oct 11;7(14). Epub 2018 Oct 11.
Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
The genome of Mycoplasma phocidae strain 105 was analyzed in order to improve our understanding of its role in epidemic marine mammal mortalities. It was found to encode a suite of immunosuppressors that may enable evasion of host defenses and modulate susceptibility to viral coinfections or their severity in seals. Read More
Curr Opin Anaesthesiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Anesthesiology, Yale School of Medicine.
Purpose Of Review: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a relatively new class of drugs used in the management of diabetes mellitus. This review will highlight key pharmacologic characteristics of this class of drugs; discuss their potential role in management of patients with cardiac disease; and raise several perioperative concerns for anesthesiologists caring for patients on SGLT-2 inhibitors.
Recent Findings: Recent trials have shown a strong mortality benefit in diabetic patients on SGLT 2 inhibitors especially in patients with a high cardiovascular burden. Read More