9,936 results match your criteria Conn Syndrome


Fate of distal aorta after frozen elephant trunk and total arch replacement for type A aortic dissection in Marfan syndrome.

J Thorac Cardiovasc Surg 2018 Aug 24. Epub 2018 Aug 24.

Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China; Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Objective: The use of the frozen elephant trunk technique for type A aortic dissection in Marfan syndrome is limited by the lack of imaging evidence for long-term aortic remodeling. We seek to evaluate the changes of the distal aorta and late outcomes after frozen elephant trunk and total arch replacement for type A aortic dissection in patients with Marfan syndrome.

Methods: Between 2003 and 2015, we performed frozen elephant trunk + total arch replacement for 172 patients with Marfan syndrome suffering from type A aortic dissection (94 acute; 78 chronic). Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.07.096DOI Listing
August 2018
4.168 Impact Factor

Frequency of Primary Hyperaldosteronism in Young Hypertensives in a Tertiary Care Setting of Rawalpindi.

J Coll Physicians Surg Pak 2019 Jan;29(1):58-61

Department of Medicine, Military Hospital, Rawalpindi, Pakistan.

Objective: To determine the frequency of primary hyperaldosteronism in young hypertensives in hospital settings of Rawalpindi.

Study Design: Cross-sectional study.

Place And Duration Of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from June 2016 to May 2017. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.01.58DOI Listing
January 2019

Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test.

Hypertens Res 2019 Jan 8. Epub 2019 Jan 8.

Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Adrenal venous sampling (AVS) is the gold standard test for distinguishing between unilateral and bilateral primary aldosteronism (PA); however, AVS requires advanced and time consuming technique. The needs for AVS have been increasing due to the increased utilization of screening for PA. An efficient selection of unilateral PA, such as aldosterone-producing adenoma (APA), before AVS is useful to avoid undesirable AVS in bilateral PA, such as idiopathic hyperaldosteronism. Read More

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http://dx.doi.org/10.1038/s41440-018-0191-5DOI Listing
January 2019

Adrenal gland disorders, active component, U.S. Armed Forces, 2002-2017.

MSMR 2018 Dec;25(12):10-19

During 2002-2017, the most common incident adrenal gland disorder among male and female service members was adrenal insufficiency and the least common was adrenomedullary hyperfunction. Adrenal insufficiency was diagnosed among 267 females (crude overall incidence rate: 8.2 cases per 100,000 person-years [p-yrs]) and 729 males (3. Read More

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December 2018

Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection.

Curr Opin Nephrol Hypertens 2019 Jan 2. Epub 2019 Jan 2.

Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Purpose Of Review: Immunohistochemistry for aldosterone synthase (CYP11B2) has markedly provided a comprehensive picture of the adrenocortical diseases, particularly primary aldosteronism. The findings from CYP11B2 immunohistochemistry are consistent with the clinical courses of most patients with primary aldosteronism. We herein review the updated pathophysiology and usefulness of the method for understanding individual patients with different subtypes of primary aldosteronism. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000487DOI Listing
January 2019
2 Reads

Proteomic Landscape of Aldosterone-Producing Adenoma.

Hypertension 2019 Feb;73(2):469-480

From the Biozentrum, University of Basel, Switzerland (M.M.S., M.C., E.D., P.J., S.M., C.P., M.N.H.), University Hospital Basel, Switzerland.

Primary aldosteronism is a disease of excessive production of adrenal steroid hormones and the most common cause of endocrine hypertension. Primary aldosteronism results mainly from bilateral adrenal hyperplasia or unilateral aldosterone-producing adenoma (APA). Primary aldosteronism cause at the molecular level is incompletely understood and a targeted treatment preventing excessive adrenal steroid production is not available. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11733DOI Listing
February 2019

Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.

Hypertension 2019 Feb;73(2):407-414

From the Department of Pharmacology (N.A.G., J.Y., E.J.S., D.A.B, P.Q.B.), University of Virginia School of Medicine, Charlottesville.

The renin-angiotensin system tightly controls aldosterone synthesis. Dysregulation is evident in hypertension (primary aldosteronism), low renin, and resistant hypertension) but also can exist in normotension. Whether chronic, mild aldosterone autonomy can elicit hypertension remains untested. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326871PMC
February 2019

Rates of Abnormal Aldosterone/ Renin ratio in African-origin compared to European-origin patients; a retrospective study.

Clin Endocrinol (Oxf) 2018 Dec 21. Epub 2018 Dec 21.

Departments of Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital.

Introduction: The aldosterone/ renin ratio is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this.

Methods: Following clinical observation of a high prevalence of abnormal ARR in patients of African origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaemia, intraventricular septal thickness (IVS, by echocardiography) and adrenal imaging were recorded when available. Read More

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http://dx.doi.org/10.1111/cen.13920DOI Listing
December 2018

Familial hyperaldosteronism type III a novel case and review of literature.

Rev Endocr Metab Disord 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, Hospital Lluís Alcanyís de Xàtiva, Ctra. Xàtiva a Silla km 2, 46800, Xàtiva, Valencia, Spain.

Less than 15% of hypertension cases in children are secondary to a primary hyperaldosteronism. This is idiopathic in 60% of the cases, secondary to a unilateral adenoma in 30% and 10% remaining by primary adrenal hyperplasia, familial hyperaldosteronism, ectopic aldosterone production or adrenocortical carcinoma.To date, four types of familial hyperaldosteronism (FH I to FH IV) have been reported. Read More

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http://link.springer.com/10.1007/s11154-018-9481-0
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http://dx.doi.org/10.1007/s11154-018-9481-0DOI Listing
December 2018
2 Reads

Villus Growth, Increased Intestinal Epithelial Sodium Selectivity, and Hyperaldosteronism Are Mechanisms of Adaptation in a Murine Model of Short Bowel Syndrome.

Dig Dis Sci 2018 Dec 20. Epub 2018 Dec 20.

Department of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Schillingallee 35, 18057, Rostock, Germany.

Background: Short bowel syndrome results from extensive small bowel resection and induces adaptation of the remaining intestine. Ileocecal resection (ICR) is the most frequent situation in humans. Villus hypertrophy is one hallmark of mucosal adaptation, but the functional mechanisms of mucosal adaptation are incompletely understood. Read More

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http://dx.doi.org/10.1007/s10620-018-5420-xDOI Listing
December 2018

A novel SLC12A3 homozygous c2039delG mutation in Gitelman syndrome with hypocalcemia.

BMC Nephrol 2018 Dec 17;19(1):362. Epub 2018 Dec 17.

The Endocrinology Department of the Third Xiangya Hospital, Central South University, Tongzipo Road, Changsha, 410013, China.

Background: Gitelman syndrome (GS) is a rare autosomal recessive renal tubular disease, caused by mutations in the SLC12A3 gene, which encodes the renal thiazide-sensitive Na/Cl cotransporter (NCCT) in the distal renal tubule.

Case Presentation: A 23-year-old woman was admitted with limb numbness, recurrent tetany and palpitation. Laboratory tests showed hypokalemic alkalosis, hypomagnesemia, hypocalcemia and secondary hyperaldosteronism, as well as hypocalciuria and transient decreased PTH. Read More

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http://dx.doi.org/10.1186/s12882-018-1163-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296056PMC
December 2018

Aldosteronism with mild hypokalemia presenting as life-threatening ventricular arrhythmias: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13608

Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Primary aldosteronism (PA) with hypokalemia increases the risk of life-threatening ventricular arrhythmias. Cases of PA with malignant arrhythmia as the first symptom have been reported. The role of severe hypokalemia in triggering malignant ventricular arrhythmia is well documented. Read More

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http://dx.doi.org/10.1097/MD.0000000000013608DOI Listing
December 2018

Simultaneous occurrence of primary aldosteronism due to aldosteronoma and ectopic meningioma in the adrenal gland: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13591

Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital, Gulou District, Nanjing City, Jiangsu Province, PR China.

Rationale: Primary aldosteronism due to aldosteronoma is the most common form of secondary hypertension, with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Diagnosis is a clinical challenge with simultaneous occurrence of primary ectopic meningioma in the adrenal gland. To our knowledge this is the first reported case of simultaneous occurrence of aldosteronomas and ectopic meningioma in the adrenal gland based on literatures. Read More

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http://dx.doi.org/10.1097/MD.0000000000013591DOI Listing
December 2018

Resistant and refractory hypertension: two sides of the same disease?

J Bras Nefrol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Medicina, Faculdade de Ciências Médicas e da Saúde, Pontifícia Universidade Católica de São Paulo, Rio de Janeiro, RJ, Brasil.

Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity. Read More

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http://dx.doi.org/10.1590/2175-8239-jbn-2018-0108DOI Listing
December 2018

Facial Malformation in Crouzon's Syndrome Is Consistent with Cranial Base Development in Time and Space.

Plast Reconstr Surg Glob Open 2018 Oct 1;6(10):e1963. Epub 2018 Oct 1.

Section of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Conn.

Background: In Crouzon's syndrome, cranial base deformities begin sequentially in the anterior cranial fossa initially, and later to the posterior cranial base. Facial characteristics are likely related to cranial base development. The temporal correlation between cranial base development and facial features is in need of clarification in Crouzon's patients, to clarify initial sites of deformity, which may impact surgical decision making. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250456PMC
October 2018

Telehealth in Plastic Surgery: A Veterans Affairs Hospital Perspective.

Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1840. Epub 2018 Oct 2.

Department of Plastic Surgery, Yale University, Cedar Street, New Haven, Conn.

Background: Telemedicine is a rapidly growing tool since its invention in the 1950s. Recently, it has expanded to the field of plastic surgery. In the Connecticut VA System, there is 1 plastic surgeon at a central location for the state of Connecticut and southern Massachusetts. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250470PMC
October 2018
1 Read

Usefulness of Magnetic Resonance Imaging in the Diagnosis of Juxtaglomerular Cell Tumors: A Report of 10 Cases and Review of the Literature.

Am J Kidney Dis 2018 Dec 4. Epub 2018 Dec 4.

Hypertension Unit, AP-HP, Hôpital Européen Georges Pompidou, Paris, France; Faculty of Medicine, Paris-Descartes University, Paris, France. Electronic address:

Juxtaglomerular cell tumors (JCTs), a rare but potentially curable cause of hypertension, are difficult to diagnose because they may be missed or misidentified as a cyst by computed tomography (CT). Their magnetic resonance imaging (MRI) pattern has not been well described. We report the clinical, biological, and radiologic features of 10 patients with JCTs. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.09.005DOI Listing
December 2018
1 Read

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 6. Epub 2018 Dec 6.

Oregon Institute of Occupational Health Sciences, Oregon Health & Science University.

Introduction: Measurements of aldosterone for diagnosis of primary aldosteronism are usually made from blood sampled in the morning when aldosterone typically peaks. We tested the relative contributions and interacting influences of the circadian system, ongoing behaviors and prior sleep to this morning peak in aldosterone.

Methods: To determine circadian rhythmicity and separate effect of behaviors on aldosterone, 16 healthy participants completed a 5-day protocol in dim-light while all behaviors ranging from sleep to exercise were standardized and scheduled evenly across the 24-h circadian period. Read More

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http://dx.doi.org/10.1152/ajpregu.00314.2018DOI Listing
December 2018
1 Read

Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism.

Endocrinol Metab (Seoul) 2018 Dec;33(4):485-492

Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Background: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients. Read More

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http://dx.doi.org/10.3803/EnM.2018.33.4.485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279903PMC
December 2018
2 Reads

Bone health among patients with primary aldosteronism: a systematic review and meta-analysis.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

Clinical Academic Unit, Newcastle University Medicine Malaysia, Johor, Malaysia.

Background: Recent studies showed a possible association between hyperaldosteronism and secondary hyperparathyroidism leading to reduced bone health, however results are conflicting.

Methods: We conducted a meta-analysis to evaluate the relationship between primary aldosteronism (PA) with bone biochemical markers and to assess bone mineral density in patients with primary aldosteronism.

Results: A total of 939 subjects were examined (37. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02867-5DOI Listing
November 2018
2 Reads

Somatic mutations in adrenocortical carcinoma with hyperaldosteronism.

Endocr Relat Cancer 2018 Nov 1. Epub 2018 Nov 1.

T Else, Metabolism, Endocrinology and Diabetes/Internal Medicine, University of Michigan, Ann Arbor, United States.

Several somatic mutations specific to aldosterone-producing adenomas (APA) have been described. A small proportion of adrenocortical carcinomas (ACC) are associated with hyperaldosteronism, either primary aldosteronism or hyperreninemic hyperaldosteronism. However, it is unknown, whether they harbor mutations of the same spectrum as APAs. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-18-
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http://dx.doi.org/10.1530/ERC-18-0385DOI Listing
November 2018
9 Reads

Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study.

Surgery 2018 Nov 22. Epub 2018 Nov 22.

Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group, Taipei; Division of Urology, Department of Surgery, Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, New Taipei City, Taiwan. Electronic address:

Background: An elevated plasma aldosterone level has been reported as an independent risk factor for severe erectile dysfunction in men. The aim of this study was to explore whether primary hyperaldosteronism patients experience erectile dysfunction after targeted treatment.

Methods: We conducted a population-based cohort study of men with newly identified primary hyperaldosteronism/aldosterone-producing adenoma from January 1, 1997, to December 31, 2009. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183055
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http://dx.doi.org/10.1016/j.surg.2018.08.020DOI Listing
November 2018
6 Reads
3.380 Impact Factor

Risk of sepsis in patients with primary aldosteronism.

Crit Care 2018 11 21;22(1):313. Epub 2018 Nov 21.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the possibility of the infection risk; however, clinical episodes of sepsis have not been reported in PA.

Methods: Using Taiwan's National Health Insurance Research Database between 1997 and 2009, we identified PA and aldosterone-producing adenoma (APA) matched with essential hypertension (EH) at a 1:1 ratio by propensity scores. Read More

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http://dx.doi.org/10.1186/s13054-018-2239-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249889PMC
November 2018
10 Reads

Speckle Tracking Echocardiographic Layer-specific Strain Analysis on Subclinical Left Ventricular Dysfunction in Patients with Primary Aldosteronism.

Am J Hypertens 2018 Nov 21. Epub 2018 Nov 21.

The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Primary aldosteronism (PA) may cause myocardial injury. We investigated myocardial dysfunction using speckle tracking echocardiographic (STE) layer-specific strain in patients with PA.

Methods: Our study included 62 patients with PA (33 aldosterone-producing adenoma [APA] and 29 idiopathic hyperaldosteronism [IHA]) and 30 patients with primary hypertension. Read More

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http://dx.doi.org/10.1093/ajh/hpy175DOI Listing
November 2018
1 Read
2.852 Impact Factor

Diagnostic challenges and good treatment outcomes in pediatric paraganglioma of the abdomen: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13268

Pathology Department, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, Hainan, PR China.

Rationale: Paraganglioma is a catecholamine-producing neuroendocrine tumor. Management of paraganglioma including its diagnosis is difficult, because it has no characteristic symptoms and many diseases can manifest as headache and high blood pressure. Herein, we report a rare case of paraganglioma of the abdomen with headache and initial normal blood pressure. Read More

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http://dx.doi.org/10.1097/MD.0000000000013268DOI Listing
November 2018
4 Reads

Spironolactone in the treatment of hypertension: a neglected molecule.

Authors:
Jiří Veselý

Vnitr Lek 2018 ;64(7-8):815-820

Spironolactone, a mineralocorticoid receptor antagonist, is used in the treatment of hypertension for over 50 years. Due to the absence of morbidity and mortality studies, it is not considered to be a first-choice drug in the treatment of patients with primary hyperaldosteronism. However, it has a secure and stable position in the treatment of resistant hypertension. Read More

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January 2018
15 Reads

10 good reasons why adrenal vein sampling is the preferred method for referring primary aldosteronism patients for adrenalectomy.

J Hypertens 2018 Nov 13. Epub 2018 Nov 13.

Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan.

: Nowadays most patients diagnosed with surgically curable primary aldosteronism have small or micro aldosterone-producing adenoma or unilateral micronodular hyperplasia, which are undetectable with available imaging technologies. Therefore, a negative imaging test by no means excludes unilateral primary aldosteronism. Moreover, about 10% of the subjects above the age of 35 years have nonfunctioning adrenal tumors, regardless of being hypertensive or not, with a prevalence that raises with aging. Read More

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http://Insights.ovid.com/crossref?an=00004872-900000000-9731
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http://dx.doi.org/10.1097/HJH.0000000000001939DOI Listing
November 2018
4 Reads

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.

Physiol Rep 2018 Nov;6(21):e13912

INSERM U942, Paris Diderot University, Paris, France.

We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca -homeostasis, pro/anti-hypertrophic, endoplasmic reticulum stress (ER stress), pro- or anti-apoptotic effectors, and MAP kinase activation, and redox signaling. These protein expressions were assessed by immunoblotting at 9 weeks after surgery. Read More

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http://doi.wiley.com/10.14814/phy2.13912
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http://dx.doi.org/10.14814/phy2.13912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236131PMC
November 2018
4 Reads

Primary aldosteronism diagnosed in a patient with severe renal disease.

Tunis Med 2018 Jul;96(7):454-457

Although initially considered a rarity, primary aldosteronism now is one of the more common causes of secondary hypertension. Based on older data, it was originally estimated that primary aldosteronism accounted for less than 1% of all patients with hypertension. Subsequent data, however, indicated that it may actually occur in as many as 5-15% of patients with hypertension. Read More

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July 2018
11 Reads

[Endocrinology: What are the most important practically relevant advances over the last ten years?]

MMW Fortschr Med 2018 11;160(Suppl 3):54-58

Medizinische Klinik und Polklinik IV, Klinikum der Universität München, Ziemssenstrasse 1, D-80336, München, Deutschland.

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http://link.springer.com/10.1007/s15006-018-1123-7
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http://dx.doi.org/10.1007/s15006-018-1123-7DOI Listing
November 2018
4 Reads

Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.

J Hypertens 2018 Nov 9. Epub 2018 Nov 9.

Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine.

Objective: Primary aldosteronism is one of the most common cause of secondary hypertension. It is well known that the incidence of cardiovascular events is higher in patients with primary aldosteronism than in patients with essential hypertension. In a previous study, we showed that aldosterone-producing adenoma is associated with vascular function and structure. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001989DOI Listing
November 2018
1 Read

Renin dependent hypertension caused by accessory renal arteries.

Clin Hypertens 2018 1;24:15. Epub 2018 Nov 1.

Department of Medicine, Sarawak General Hospital, Ministry of Health Malaysia, Jalan Hospital, 93586 Kuching, Sarawak Malaysia.

Background: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants in the vascular anatomy which are often thought to be innocuous but in some circumstances can cause renovascular hypertension leading to secondary hyperaldosteronism.

Case Presentation: We report 2 cases of hypertension with secondary hyperaldosteronism associated with accessory renal arteries. Read More

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https://clinicalhypertension.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40885-018-0100-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211501PMC
November 2018
9 Reads

Two neonates with Bartter syndrome.

J Pak Med Assoc 2018 Nov;68(11):1721-1723

Children hospital, Pakistan Institute of Medical Sciences, Islamabad.

Bartter syndrome is an autosomal recessive disorder caused by gene mutations that involve hypokalaemia, hypochloraemia and metabolic alkalosis along with raised serum renin, hyperaldosteronism and normal blood pressure. We report two cases of neonatal Bartter syndrome. Case 1 was a product of non-consanguineous marriage and mother had unexplained polyhydramnios in pregnancy while case 2 was a product of consanguineous marriage. Read More

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November 2018
8 Reads

Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl/H Antiporter ClC-5.

Front Physiol 2018 23;9:1490. Epub 2018 Oct 23.

Institute for Neurophysiology, Hannover Medical School, Hanover, Germany.

Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl/H antiporter ClC-5. The disease typically manifests with proteinuria, hypercalciuria, nephrocalcinosis, and nephrolithiasis but is characterized by large phenotypic variability of no clear origin. Several DD1 cases have been reported lately with additional atypical hypokalemic metabolic alkalosis and hyperaldosteronism, symptoms usually associated with another renal disease termed Bartter syndrome (BS). Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01490
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http://dx.doi.org/10.3389/fphys.2018.01490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206076PMC
October 2018
4 Reads

Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study.

Hypertens Res 2019 Jan 6;42(1):40-51. Epub 2018 Nov 6.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

It remains unknown which surrogate markers can predict diagnostic test results for primary hyperaldosteronism (PA). The Secondary Hypertension Registry Investigation in Mie Prefecture (SHRIMP) study has sequentially and prospectively recruited 128 patients with hypertension with an aldosterone-to-renin ratio (ARR) greater than 20, evaluated the differences among essential hypertension (EHT), idiopathic hyperaldosteronism (IHA), and aldosterone-producing adenoma (APA), and analyzed the predictors for the confirmatory tests. The patients underwent saline-loading, captopril-challenge, and upright furosemide-loading tests. Read More

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http://www.nature.com/articles/s41440-018-0126-1
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http://dx.doi.org/10.1038/s41440-018-0126-1DOI Listing
January 2019
8 Reads

Relationship Between Visceral Fat and Plasma Aldosterone Concentration in Patients With Primary Aldosteronism.

J Endocr Soc 2018 Nov 17;2(11):1236-1245. Epub 2018 Sep 17.

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Context: The involvement of visceral fat in aldosterone secretion has not been reported in patients with primary aldosteronism (PA). Patients with PA are complicated by metabolic syndrome more frequently than those without PA. An excess of visceral fat has been hypothesized to cause an elevation of aldosterone secretion in patients with PA. Read More

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https://academic.oup.com/jes/article/2/11/1236/5096835
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http://dx.doi.org/10.1210/js.2018-00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199893PMC
November 2018
7 Reads

The patient with metabolic alkalosis.

Acta Clin Belg 2018 Oct 27:1-7. Epub 2018 Oct 27.

a Division of Nephrology , Cliniques universitaires Saint-Luc , Brussels , Belgium.

Metabolic alkalosis defined by the increase of both plasma HCO3- level (>26 mmol/L) and blood arterial pH (>7.43) is quite frequent and usually accompanied by hypokalemia. Its pathogenesis requires both the generation of alkalosis and its maintenance. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1539373DOI Listing
October 2018
7 Reads

Primary Aldosteronism.

Circulation 2018 Aug;138(8):823-835

Division of Metabolism, Endocrinology, and Diabetes (A.F.T., R.J.A.).

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many cases, somatic mutations in ion channels and pumps within adrenal cells initiate the pathogenesis of PA, and this mechanism might explain why PA is so common and suggests that milder and evolving forms of PA must exist. Compared with primary hypertension, PA causes more end-organ damage and is associated with excess cardiovascular morbidity, including heart failure, stroke, nonfatal myocardial infarction, and atrial fibrillation. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205759PMC
August 2018
1 Read

Plasma Aldosterone Concentration as a Determinant for Statin Use among Middle-Aged Hypertensive Patients for Atherosclerotic Cardiovascular Disease.

J Clin Med 2018 Oct 24;7(11). Epub 2018 Oct 24.

Department of Internal Medicine, Division of Nephrology, National Taiwan University Hospital, Taipei 100, Taiwan.

The use of statin therapy on the prevention of atherosclerotic cardiovascular disease (ASCVD) is recommended by the American College of Cardiology (ACC) and the American Heart Association (AHA); nevertheless, its validation on primary aldosteronism (PA) patients has not been reported. We investigated the risk of incident ASCVD in middle-aged patients with PA compared with essential hypertension (EH) based on ACC/AHA recommendations. We enrolled 461 PA patients and 553 EH patients. Read More

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http://www.mdpi.com/2077-0383/7/11/382
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http://dx.doi.org/10.3390/jcm7110382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262476PMC
October 2018
5 Reads

Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma.

Hypertension 2018 Sep;72(3):632-640

From the Department of Pathology (Y.Y., K.I., Y.N., H.S.).

Aldosterone-producing adenomas (APAs) harbor marked intratumoral heterogeneity in terms of morphology, steroidogenesis, and genetics. However, an association of biological significance of morphologically identified tumor cell subtypes and genotypes is virtually unknown. KCNJ5 mutation is most frequently detected and generally considered a curable phenotype by adrenalectomy. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.10907DOI Listing
September 2018
6 Reads

Idiopathic Hyperaldosteronism.

Authors:
John W Funder

Hypertension 2018 Oct;72(4):839-840

From the Hudson Institute of Medical Research and Monash University, Victoria, Australia.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11174DOI Listing
October 2018

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.

Hypertension 2018 Oct;72(4):874-880

Department of Molecular and Integrative Physiology (W.E.R.), and Department of Medicine (W.E.R.), University of Michigan, Ann Arbor.

Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral and bilateral forms. Most unilateral primary aldosteronism is caused by computed tomography-detectable aldosterone-producing adenomas, which express CYP11B2 (aldosterone synthase) and frequently harbor somatic mutations in aldosterone-regulating genes. The cause of the most common bilateral form of primary aldosteronism, idiopathic hyperaldosteronism (IHA), is believed to be diffuse hyperplasia of aldosterone-producing cells within the adrenal cortex. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207209PMC
October 2018
8 Reads

Sustaining the momentum: Negative cross-sectional imaging for primary hyperaldosteronism should not preclude endocrine surgical referral.

Surgery 2019 Jan 19;165(1):219-220. Epub 2018 Oct 19.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1016/j.surg.2018.08.032DOI Listing
January 2019
1 Read

Aldosterone-sensitive HSD2 neurons in mice.

Brain Struct Funct 2018 Oct 20. Epub 2018 Oct 20.

Department of Neurology, University of Iowa, PBDB 1320, 169 Newton Rd., Iowa City, IA, 52246, USA.

Sodium deficiency elevates aldosterone, which in addition to epithelial tissues acts on the brain to promote dysphoric symptoms and salt intake. Aldosterone boosts the activity of neurons that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a hallmark of aldosterone-sensitive cells. To better characterize these neurons, we combine immunolabeling and in situ hybridization with fate mapping and Cre-conditional axon tracing in mice. Read More

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http://link.springer.com/10.1007/s00429-018-1778-y
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http://dx.doi.org/10.1007/s00429-018-1778-yDOI Listing
October 2018
12 Reads

Endovascular iliac vein recanalization after Palma procedure for treatment of recalcitrant venous ulcer.

J Vasc Surg Venous Lymphat Disord 2018 Nov;6(6):762-764

Section of Vascular Surgery, Department of Surgery, Yale School of Medicine, New Haven, Conn.

A 57-year-old man with post-thrombotic syndrome presented to the vascular clinic with multiple recurrent nonhealing ulcerations, swelling, and hyperpigmentation of the right lower extremity 30 years after a Palma procedure. On venography, a right to left femoral-femoral Palma bypass graft was noted to be patent, with occlusion of the iliac vein. Endovascular stenting of the right iliac veins led to complete resolution of symptoms and ulcer healing. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.05.022DOI Listing
November 2018

[Alteration of left ventricular longitudinal systolic function in 2D-strain in primary aldosteronism: A new target organ damage marker].

Ann Cardiol Angeiol (Paris) 2018 Nov 14;67(5):315-320. Epub 2018 Oct 14.

Centre d'excellence en hypertension artérielle, hôpital St-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.

Objective: Primary hyperaldosteronism is the leading cause of secondary hypertension, and leads to frequent cardiovascular complications. Many studies have studied left ventricular geometry and function in this population, but longitudinal systolic function is still poorly described.

Methods: We studied 35 hypertensive patients with primary aldosteronism, and 35 with essential hypertension matched for age, sex, body mass index, and 24h blood pressure. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.08.007DOI Listing
November 2018
1 Read

Low Levels of Renin and High Aldosterone-to-Renin Ratio Among Rheumatoid Patients and Ankylosing Spondylitis Patients: A Prospective Study.

Isr Med Assoc J 2018 10;20(10):632-636

Department of Medicine 'B', Sheba Medical Center, Tel Hashomer, Israel.

Background: Patients with rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS), encounter significantly higher rates of cardiovascular morbidity and mortality. The renin-angiotensin-aldosterone system maintains hemodynamic stability through blood pressure regulation. When dysregulated, this system has been implicated in various pathological conditions, including cardiovascular events. Read More

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October 2018
3 Reads

Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging.

Eur Heart J Cardiovasc Imaging 2018 Oct 10. Epub 2018 Oct 10.

Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany.

Aims: Sodium intake has been linked to left ventricular hypertrophy independently of blood pressure, but the underlying mechanisms remain unclear. Primary hyperaldosteronism (PHA), a condition characterized by tissue sodium overload due to aldosterone excess, causes accelerated left ventricular hypertrophy compared to blood pressure matched patients with essential hypertension. We therefore hypothesized that the myocardium constitutes a novel site capable of sodium storage explaining the missing link between sodium and left ventricular hypertrophy. Read More

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http://dx.doi.org/10.1093/ehjci/jey134DOI Listing
October 2018
10 Reads

Estimation of sodium and chloride storage in critically ill patients: a balance study.

Ann Intensive Care 2018 Oct 11;8(1):97. Epub 2018 Oct 11.

Department of Critical Care, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

Background: Nonosmotic sodium storage has been reported in animals, healthy individuals and patients with hypertension, hyperaldosteronism and end-stage kidney disease. Sodium storage has not been studied in ICU patients, who frequently receive large amounts of sodium chloride-containing fluids. The objective of our study was to estimate sodium that cannot be accounted for by balance studies in critically ill patients. Read More

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http://dx.doi.org/10.1186/s13613-018-0442-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179979PMC
October 2018