1,903 results match your criteria Conjunctivitis Neonatal


Ophthalmia Neonatorum.

Authors:
Aik-Kah Tan

N Engl J Med 2019 Jan;380(2):e2

Normah Medical Specialist Center, Kuching, Malaysia

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http://dx.doi.org/10.1056/NEJMicm1808613DOI Listing
January 2019

The newborn conjunctival flora at the post delivery 24 hours.

J Curr Ophthalmol 2018 Dec 10;30(4):348-352. Epub 2018 Apr 10.

Department of Microbiology, Kayseri Training and Education Hospital, Kayseri, Turkey.

Purpose: The aim of this study was to investigate the aerobic conjunctival flora of neonates and the effects of delivery type on conjunctival flora development in neonates who were born with normal spontaneous vaginal delivery (SVD) or elective caesarean section (C/S) and who were not given prophylactic antibiotic eye drops after birth.

Methods: This cross-sectional study included 95 healthy newborns. One day after the delivery, conjunctival samples were taken from newborns who were born with normal SVD or elective C/S, and not given prophylactic antibiotic eye drops after birth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24522325173014
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http://dx.doi.org/10.1016/j.joco.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276619PMC
December 2018
10 Reads

Neonatal conjunctivitis in the New Zealand Midland region.

N Z Med J 2018 Nov 30;131(1486):9-17. Epub 2018 Nov 30.

Ophthalmologist, Clinical Senior Lecturer, Ophthalmology Department, Department of Medicine, Hauora Tairawhiti, University of Otago, Gisborne.

Aims: To assess the incidence of chlamydial and gonorrhoeal neonatal conjunctivitis (CON and GON), across six district health boards in the greater Midland region of New Zealand.

Methods: All positive nucleic acid amplification test (NAAT) eye swabs for Chlamydia trachomatis and NAAT and bacterial eye swabs for Neisseria gonorrhoeae in infants under one year of age were retrieved from three laboratories from 2013-2016. Incidence density rates were calculated using births information from Statistics New Zealand. Read More

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November 2018
12 Reads

Neonatal Conjunctivitis Caused by Neisseria cinerea: A Case of Mistaken Identity.

J Pediatric Infect Dis Soc 2018 Nov 21. Epub 2018 Nov 21.

Division of Pediatric Infectious Diseases, Department of Pediatrics, NYU Winthrop Hospital, Mineola, New York.

We report a case of a 3-day-old boy with Neisseria cinerea conjunctivitis, originally misidentified as Neisseria gonorrhoeae conjunctivitis. Neonates are at increased risk for disseminated gonococcal infection, and physicians should be cognizant of N cinerea and its potential to be mistaken for N gonorrhoeae. Read More

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http://dx.doi.org/10.1093/jpids/piy116DOI Listing
November 2018
7 Reads

A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices.

Med Sci Monit 2018 Nov 10;24:8042-8047. Epub 2018 Nov 10.

Psychiatric Hospital "Sveti Ivan", Zagreb, Croatia.

BACKGROUND Ophthalmia neonatorum, or neonatal conjunctivitis, is an acute infection that occurs within the first 28 days of life. This aim of this survey was to evaluate the current methods of preventive treatment for ophthalmia neonatorum in maternity hospitals in Croatia. MATERIAL AND METHODS The annual hospital birth rate in Croatia is approximately 40,000. Read More

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https://www.medscimonit.com/abstract/index/idArt/910705
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http://dx.doi.org/10.12659/MSM.910705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240167PMC
November 2018
6 Reads

Serratia marcescens outbreak in a neonatology unit of a Spanish tertiary hospital: Risk factors and control measures.

Am J Infect Control 2018 Nov 1. Epub 2018 Nov 1.

Department of Preventive Medicine, La Paz University Hospital, Madrid, Spain.

Background: We describe the investigation undertaken and the measures adopted to control a Serratia marcescens outbreak in the neonatology unit of La Paz University Hospital in Madrid, Spain.

Methods: Weekly rectal and pharyngeal screenings for S marcescens were performed in the neonates starting after detection of the outbreak. Environmental samples and samples from health care workers (HCWs) were obtained for microbiological analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553183090
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http://dx.doi.org/10.1016/j.ajic.2018.08.026DOI Listing
November 2018
7 Reads

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease.

Front Microbiol 2018 8;9:2422. Epub 2018 Oct 8.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.

Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot, and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by EVs of the family including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10, and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02422
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http://dx.doi.org/10.3389/fmicb.2018.02422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186807PMC
October 2018
14 Reads

Identifying a sufficient core group for trachoma transmission.

PLoS Negl Trop Dis 2018 10 8;12(10):e0006478. Epub 2018 Oct 8.

F.I. Proctor Foundation, University of California San Francisco, San Francisco, CA, United States of America.

Background: In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006478
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http://dx.doi.org/10.1371/journal.pntd.0006478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175502PMC
October 2018
9 Reads

Investigation of an outbreak caused by antibiotic-susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway.

Acta Paediatr 2019 Jan 9;108(1):76-82. Epub 2018 Oct 9.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Aim: Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway between April 2016 and April 2017. Read More

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http://dx.doi.org/10.1111/apa.14584DOI Listing
January 2019
1 Read

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.

J Pediatric Infect Dis Soc 2018 Aug;7(3):e107-e115

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: With the continued high prevalence of chlamydia worldwide and high risk of transfer from mothers to their infant during delivery, a need for safe and effective therapies for infants who acquire a chlamydial infection remains. We conducted a systematic review and meta-analysis of antibiotic treatments, including oral erythromycin, azithromycin, and trimethoprim, for neonatal chlamydial conjunctivitis.

Methods: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to July 14, 2017. Read More

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http://dx.doi.org/10.1093/jpids/piy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097578PMC
August 2018
8 Reads

Kawasaki Disease in the neonate: case report and literature review.

Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. Epub 2018 Jul 3.

Division of Rheumatology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5980 University Ave, Halifax, NS, B3K 6R8, Canada.

Background: Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD.

Case Presentation: A previously healthy full term 15 day old Caucasian male with an unremarkable antenatal and perinatal history, presented on Day 2 of illness with fever, rash, irritability, and poor feeding. Read More

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http://dx.doi.org/10.1186/s12969-018-0263-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029347PMC
July 2018
3 Reads

Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study.

Acta Ophthalmol 2018 Dec 9;96(8):789-794. Epub 2018 Jun 9.

Lysningen Research Center, Trekroner, Denmark.

Purpose: Acute infectious conjunctivitis is a common disease. While usually self-limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0-4 years in Denmark, Norway and Sweden. Read More

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http://dx.doi.org/10.1111/aos.13813DOI Listing
December 2018
6 Reads

Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project.

Environ Health Perspect 2018 04 12;126(4):047005. Epub 2018 Apr 12.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear.

Objectives: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence.

Methods: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Read More

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http://dx.doi.org/10.1289/EHP2738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071724PMC
April 2018
38 Reads

Case 1: Eye Discharge in a 10-day-old Neonate Born by Cesarean Delivery.

Pediatr Rev 2018 Apr;39(4):210

Department of Pediatrics, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1542/pir.2016-0090DOI Listing
April 2018
2 Reads

Optimizing Accessibility of a Hand-wash Gel to Infant's Cradle: Effect on Neonatal Conjunctivitis.

Pediatr Infect Dis J 2019 Jan;38(1):e7-e11

Department of Neonatology.

Background: In our recent study in 2015, we showed a significant relationship between increased rate of clinical neonatal conjunctivitis (CNC) and performance of eye red reflex examination. Our study aim was to assess whether improved accessibility of staff to disinfectant gel (via attaching the gel bottle to infant's cradle) will increase the caring staff compliance with hand hygiene and decrease the rate of CNC.

Methods: Our intervention included attaching bottles of alcohol-based gel to newborns' cradles to ensure full availability and accessibility of hand-wash disinfectant. Read More

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http://dx.doi.org/10.1097/INF.0000000000002023DOI Listing
January 2019
3 Reads

Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013.

BMC Infect Dis 2018 03 20;18(1):135. Epub 2018 Mar 20.

Beijing Center for Disease Prevention and Control, No.16, Hepingli Middle Road, Beijing, 100013, People's Republic of China.

Background: Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China. However, little is known about the epidemiology and type distribution of acute adenoviral conjunctivitis in Beijing.

Methods: Acute conjunctivitis surveillance was conducted in 18 hospitals in Beijing from July through October during 2011-2013. Read More

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http://dx.doi.org/10.1186/s12879-018-3014-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859447PMC
March 2018
8 Reads
2.610 Impact Factor

Update: Noncongenital Zika Virus Disease Cases - 50 U.S. States and the District of Columbia, 2016.

MMWR Morb Mortal Wkly Rep 2018 Mar 9;67(9):265-269. Epub 2018 Mar 9.

Zika virus is a flavivirus primarily transmitted to humans by Aedes aegypti mosquitoes (1). Zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). Most Zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or nonpurulent conjunctivitis; Guillain-Barré syndrome, meningoencephalitis, and severe thrombocytopenia rarely have been associated with Zika virus infection (1). Read More

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http://dx.doi.org/10.15585/mmwr.mm6709a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844284PMC
March 2018
16 Reads

Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the “molecular age”: investigation for a correct therapy.

J Biol Regul Homeost Agents 2018 Jan-Feb;32(1):177-184

Department of Medical, Oral, and Biotechnological Sciences; “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy.

An early double case of acute Ophthalmia neonatorum in 3-day-old twins is reported. Culture of eye swabs showed a wide bacterial polymorphism, in which common bacteria, such as Klebsiella pneumoniae, Streptococcus pneumoniae, Corynebacterium ulcerans and other Enterobacteriaceae, coexisted with atypical Mycoplasmataceae and Chlamydiaceae from resident cervical-vaginal maternal microbiota. The neonates were in an apparently healthy state, but showed red eyes with abundant greenish-yellow secretion, mild chemosis and lid edema. Read More

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April 2018
6 Reads

Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia.

PLoS Negl Trop Dis 2018 02 16;12(2):e0006270. Epub 2018 Feb 16.

Trachoma Control Program, The Carter Center, Atlanta, Georgia, United States of America.

Background: Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiveness of MDA programs, yet published reports from trachoma programs are rare. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833287PMC
February 2018
10 Reads

Clinical Age-Specific Seasonal Conjunctivitis Patterns and Their Online Detection in Twitter, Blog, Forum, and Comment Social Media Posts.

Invest Ophthalmol Vis Sci 2018 02;59(2):910-920

Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California, United States.

Purpose: We sought to determine whether big data from social media might reveal seasonal trends of conjunctivitis, most forms of which are nonreportable.

Methods: Social media posts (from Twitter, and from online forums and blogs) were classified by age and by conjunctivitis type (allergic or infectious) using Boolean and machine learning methods. Based on spline smoothing, we estimated the circular mean occurrence time (a measure of central tendency for occurrence) and the circular variance (a measure of uniformity of occurrence throughout the year, providing an index of seasonality). Read More

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http://dx.doi.org/10.1167/iovs.17-22818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815847PMC
February 2018
7 Reads

Impact of Water, Sanitation and Hygiene Interventions on Growth, Non-diarrheal Morbidity and Mortality in Children Residing in Low- and Middle-income Countries: A Systematic Review.

Indian Pediatr 2018 May 9;55(5):381-393. Epub 2018 Feb 9.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research; New Delhi, India. Correspondence to: Dr Harshpal Singh Sachdev, Senior Consultant, Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India.

Objective: To evaluate the impact of water, sanitation and hygiene (WASH) interventions in children (age <18 y) on growth, non-diarrheal morbidity and mortality in children.

Design: Systematic review of randomized controlled trials, non-randomized controlled trials and controlled before-after studies.

Setting: Low- and middle-income countries. Read More

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May 2018
39 Reads

[What about tropical endemic vernal keratoconjunctivitis? Which relationship with intestinal parasites?]

J Fr Ophtalmol 2018 Feb 1;41(2):152-157. Epub 2018 Feb 1.

Faculté de médecine et de sciences biomédicales, université de Yaoundé I, Yaoundé, Cameroun.

Given the causative parasite hypothesis for tropical endemic limbo-conjunctivitis (TELC), we conducted an analytical case-control study of all children with tropical endemic limbo-conjunctivitis seen in the ophthalmology department of Laquintinie hospital in Douala during the period from January 2nd to April 30, 2015.

Results: We identified 64 cases of tropical endemic limbo-conjunctivitis out of 550 children seen; a hospital prevalence of 11.6%; thirteen cases (eight boys and five girls) did not meet inclusion criteria, and 51 cases were included, 31 boys (60. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.08.006DOI Listing
February 2018

Bacterial Conjunctivitis in Childhood: Etiology, Clinical Manifestations, Diagnosis, and Management.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):120-127

Department of Family Medicine, The University of Calgary, Calgary, Alberta, Canada.

Background: Bacterial conjunctivitis is a common reason for children to be seen in pediatric practices. A correct diagnosis is important so that appropriate treatment can be instituted.

Objective: To provide an update on the evaluation, diagnosis, and treatment of bacterial conjunctivitis in children. Read More

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http://dx.doi.org/10.2174/1872213X12666180129165718DOI Listing
December 2018
6 Reads

Aetiology of neonatal conjunctivitis evaluated in a population-based setting.

Acta Paediatr 2018 May 6;107(5):774-779. Epub 2018 Feb 6.

Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Aim: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population-based setting.

Methods: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010-2015. Conjunctival specimens were collected from 167 neonates for multiplex polymerase chain reaction to detect 16 respiratory viruses, from 163 for polymerase chain reaction to detect Chlamydia trachomatis and Neisseria gonorrhoeae and from 160 for bacterial culture studies. Read More

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http://dx.doi.org/10.1111/apa.14227DOI Listing
May 2018
4 Reads

Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial.

BMC Infect Dis 2017 12 28;17(1):799. Epub 2017 Dec 28.

London School of Hygiene and Tropical Medicine, London, UK.

Background: Vertical transmission can result in neonatal infection and disease. Reducing the transmission of bacterial pathogens from mother to infant may be an effective means of preventing neonatal infection, including bacterial conjunctivitis.

Methods: In a double-blind, randomized trial, we assessed the effect of administering a single dose of oral azithromycin to women in labour on bacterial colonization of the neonate. Read More

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http://dx.doi.org/10.1186/s12879-017-2909-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746019PMC
December 2017
12 Reads

The eyes have it: An unusual case of ophthalmia neonatorum or a shifting landscape?

SAGE Open Med Case Rep 2017 11;5:2050313X17745905. Epub 2017 Dec 11.

Division of Pediatric Hospital Medicine, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.

Despite dramatic declines in the incidence of ophthalmia neonatorum with universal prophylaxis, it remains a clinically important cause of eye disease in newborns. While clear guidelines exist for the treatment of the historically primary agents of ophthalmia neonatorum ( and ), it is less clear how to manage newborns with conjunctivitis secondary to other bacterial organisms, particularly those also frequently implicated in neonatal sepsis. We present the case of a 3-day-old well-appearing term infant with unilateral purulent conjunctivitis. Read More

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http://dx.doi.org/10.1177/2050313X17745905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734447PMC
December 2017
8 Reads

The association between a genetic risk score for allergy and the risk of developing allergies in childhood-Results of the WHISTLER cohort.

Pediatr Allergy Immunol 2018 02 22;29(1):72-77. Epub 2017 Nov 22.

Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.

Background: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.

Methods: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. Read More

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http://doi.wiley.com/10.1111/pai.12824
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http://dx.doi.org/10.1111/pai.12824DOI Listing
February 2018
9 Reads

A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China.

BMC Ophthalmol 2017 Sep 26;17(1):174. Epub 2017 Sep 26.

Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, 6400 Freret Street, New Orleans, LA, 70118, USA.

Background: The aim of the project is to retrospectively study the changes in bacterial pathogens in acute neonatal bacterial conjunctivitis from 2002 to 2016 in Southern China. The results may provide the guidance for drug choice for acute neonatal bacterial conjunctivitis.

Methods: Secretion specimens for bacterial culture were taken from 485 cases with clinically diagnosed acute bacterial neonatal conjunctivitis. Read More

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http://dx.doi.org/10.1186/s12886-017-0570-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615761PMC
September 2017
8 Reads

Interventions for treating genital Chlamydia trachomatis infection in pregnancy.

Cochrane Database Syst Rev 2017 09 22;9:CD010485. Epub 2017 Sep 22.

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch University and Tygerberg Hospital, PO Box 19063, Tygerberg, Western Cape, South Africa, 7505.

Background: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia. Read More

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http://dx.doi.org/10.1002/14651858.CD010485.pub2DOI Listing
September 2017
19 Reads

Treatment of plasminogen deficiency patients with fresh frozen plasma.

Pediatr Blood Cancer 2018 Feb 6;65(2). Epub 2017 Sep 6.

Department of Pediatric Hematology-Oncology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Congenital plasminogen (Plg) deficiency leads to the development of ligneous membranes on mucosal surfaces. Here, we report our experience with local and intravenous fresh frozen plasma (FFP). We retrospectively reviewed medical files of 17 patients and their eight first-degree relatives. Read More

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http://dx.doi.org/10.1002/pbc.26779DOI Listing
February 2018
6 Reads

Population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the Casamance region of Senegal.

BMC Public Health 2017 07 26;18(1):62. Epub 2017 Jul 26.

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.

Background: Trachoma, caused by ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. We conducted the first population-based trachoma prevalence survey in the Casamance region of Senegal to enable the Senegalese National Eye Care Programme (NECP) to plan its trachoma control activities. The World Health Organization (WHO) guidelines state that any individual with trachomatous trichiasis (TT) should be offered surgery, but that surgery should be prioritised where the prevalence is >0. Read More

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http://dx.doi.org/10.1186/s12889-017-4605-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530574PMC
July 2017
38 Reads

Prevention of Ophthalmia Neonatorum Caused by Using a Fatty Acid-Based Formulation.

MBio 2017 07 25;8(4). Epub 2017 Jul 25.

School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom

Ophthalmia neonatorum, also called neonatal conjunctivitis, acquired during delivery can occur in the first 28 days of life. Commonly caused by the bacterial pathogen , infection can lead to corneal scarring, perforation of the eye, and blindness. One approach that can be taken to prevent the disease is the use of an ophthalmic prophylaxis, which kills the bacteria on the surface of the eye shortly after birth. Read More

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http://dx.doi.org/10.1128/mBio.00534-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527305PMC
July 2017
19 Reads

Management of Extraocular Infections.

Indian J Pediatr 2017 Dec 14;84(12):945-952. Epub 2017 Jul 14.

Cornea & Refractive Services, Aravind Eye Hospital & PG Institute of Ophthalmology, 1, Anna Nagar, Madurai, Tamil Nadu, 625 020, India.

Extraocular infection is a frequently encountered problem in children including neonates and infants. Prompt recognition of the extraocular disease and management at first contact reduces the ocular morbidity and visual impairment. Delay in administering appropriate therapy and referral to an eye care personnel may result in blindness; sometimes bilateral, due to severe ophthalmia neonatorum. Read More

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http://dx.doi.org/10.1007/s12098-017-2409-yDOI Listing
December 2017
17 Reads

Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary.

J Med Microbiol 2017 Jul 10;66(7):915-918. Epub 2017 Jul 10.

4​Femicare Clinical Research for Women, Tienen, Belgium 5​Department of Obstetrics and Gynecology, University Hospital Antwerp, Edegem, Belgium.

The objective of the present study was to determine the frequency and age distribution of different Chlamydia trachomatis (CT) genotypes causing ophthalmia neonatorum (ON) in Hungary. Using CT specific PCR, we tested 76 conjunctival samples from symptomatic infants up to 3 months old in the National Centre for Epidemiology, Budapest between 2008 and 2016. CT tested positive in 30 of 76 conjunctival samples (39. Read More

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http://dx.doi.org/10.1099/jmm.0.000523DOI Listing
July 2017
12 Reads

Risk factors for measles death: Kyegegwa District, western Uganda, February-September, 2015.

BMC Infect Dis 2017 07 3;17(1):462. Epub 2017 Jul 3.

Uganda Public Health Fellowship Program - Field Epidemiology Track, Kampala, Uganda.

Background: On 18 August 2015, Kyegegwa District reported eight deaths during a measles outbreak to the Uganda Ministry of Health (MoH). We investigated this death cluster to verify the cause, identify risk factors, and inform public health interventions.

Methods: We defined a probable measles case as onset of fever and generalised rash in a Kyegegwa District resident from 1 February - 15 September 2015, plus ≥1 of the following: coryza, conjunctivitis, and cough. Read More

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http://dx.doi.org/10.1186/s12879-017-2558-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496348PMC
July 2017
3 Reads

Genome-wide codon usage profiling of ocular infective Chlamydia trachomatis serovars and drug target identification.

J Biomol Struct Dyn 2018 Jun 4;36(8):1979-2003. Epub 2017 Jul 4.

a Centre for Bioinformatics , Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Sankara Nethralaya , Chennai 600 006 , Tamil Nadu , India.

Chlamydia trachomatis (C.t) is a Gram-negative obligate intracellular bacteria and is a major causative of infectious blindness and sexually transmitted diseases. Among the varied serovars of this organism, A, B and C are reported as prominent ocular pathogens. Read More

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http://dx.doi.org/10.1080/07391102.2017.1343685DOI Listing
June 2018
6 Reads

Antibiotic Prescription Fills for Acute Conjunctivitis among Enrollees in a Large United States Managed Care Network.

Ophthalmology 2017 08 16;124(8):1099-1107. Epub 2017 Jun 16.

W. K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, Michigan; Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, Michigan. Electronic address:

Purpose: Antibiotics are seldom necessary to treat acute conjunctivitis. We assessed how frequently patients with newly diagnosed acute conjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiotic prescription fills.

Design: Retrospective, observational cohort study. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.04.034DOI Listing
August 2017
75 Reads

Pregnancy Outcomes After Maternal Zika Virus Infection During Pregnancy - U.S. Territories, January 1, 2016-April 25, 2017.

MMWR Morb Mortal Wkly Rep 2017 Jun 16;66(23):615-621. Epub 2017 Jun 16.

Pregnant women living in or traveling to areas with local mosquito-borne Zika virus transmission are at risk for Zika virus infection, which can lead to severe fetal and infant brain abnormalities and microcephaly (1). In February 2016, CDC recommended 1) routine testing for Zika virus infection of asymptomatic pregnant women living in areas with ongoing local Zika virus transmission at the first prenatal care visit, 2) retesting during the second trimester for women who initially test negative, and 3) testing of pregnant women with signs or symptoms consistent with Zika virus disease (e.g. Read More

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http://dx.doi.org/10.15585/mmwr.mm6623e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657842PMC
June 2017
51 Reads

Zika Virus Infection in Pregnant Women and Microcephaly.

Rev Bras Ginecol Obstet 2017 05 2;39(5):235-248. Epub 2017 Jun 2.

Universidade de São Paulo, São Paulo, SP, Brazil.

From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damage to the central nervous system is known to be multiple, and microcephaly is considered the tip of the iceberg. Microcephaly actually represents the epilogue of this infection's devastating process on the central nervous system of embryos and fetuses. Read More

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http://dx.doi.org/10.1055/s-0037-1603450DOI Listing
May 2017
80 Reads

Zika Virus: Obstetric and Pediatric Anesthesia Considerations.

Anesth Analg 2017 06;124(6):1918-1929

From *Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida; †Jackson Memorial Hospital, Miami, Florida; ‡Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida; §Division of Infectious Diseases, Department of Medicine, University of Miami, Miami Miller School of Medicine, Miami, Florida; and ‖UM-JMH Center for Patient Safety, Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida.

As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. Read More

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http://dx.doi.org/10.1213/ANE.0000000000002047DOI Listing
June 2017
21 Reads

Keeping an Eye on Chlamydia and Gonorrhea Conjunctivitis in Infants in the United States, 2010-2015.

Sex Transm Dis 2017 06;44(6):356-358

From the * Division of STD Prevention, Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA.

Perinatal transmission of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) can result in conjunctivitis in infants. We examined national rates of reported CT/GC conjunctivitis among infants. Surveillance of these infections is heavily affected by the completeness of reported data on specimen source and age. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527667PMC
June 2017
10 Reads

Erythromycin Prophylaxis for Neonatal Conjunctivitis: Ointment Versus Drops.

Isr Med Assoc J 2016 Jul;18(7):404-406

Department of Neonatology, Rappaport Children's Hospital, Rambam Health Care Campus, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Due to a shortage of individualized erythromycin ointment (IEO), we switched to shared erythromycin drops (SED). Following this change, nurses claimed observing more cases of eye discharge.

Objectives: To test whether switching from IEO to SED affected the rate of neonatal conjunctivitis (NC). Read More

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July 2016
5 Reads

Intravitreal anti-VEGF treatment for retinopathy of prematurity in infants with active adenoviral keratoconjunctivitis.

Cutan Ocul Toxicol 2018 Mar 27;37(1):15-18. Epub 2017 Apr 27.

a Department of Ophthalmology , Adana Numune Training and Research Hospital , Adana , Turkey.

Purpose: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC).

Material And Methods: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP. The infants were divided into two groups. Read More

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http://dx.doi.org/10.1080/15569527.2017.1317784DOI Listing
March 2018
7 Reads

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of in Mother's Vagina and Both Parents' Nasopharynx.

Case Rep Infect Dis 2017 6;2017:6132857. Epub 2017 Mar 6.

Department of Microbiology, Hospital General de Tijuana, Tijuana, BC, Mexico.

Neonatal conjunctivitis is usually associated with vagina's infection by sp., , and/or other bacteria during delivery. Meningococcal neonatal conjunctivitis is an extremely rare disease. Read More

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http://dx.doi.org/10.1155/2017/6132857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358437PMC
March 2017
8 Reads

Paediatric Virology: A rapidly increasing educational challenge.

Exp Ther Med 2017 Feb 23;13(2):364-377. Epub 2016 Dec 23.

Department of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece.

The '2nd Workshop on Paediatric Virology', which took place on Saturday the 8th of October 2016 in Athens, Greece, provided an overview on recent views and advances on Paediatric Virology. Emphasis was given to HIV-1 management in Greece, a country under continuous financial crisis, hepatitis B vaccination in Africa, treatment options for hepatitis C virus in childhood, Zika virus in pregnancy and infancy, the burden of influenza on childhood, hand-foot-mouth disease and myocarditis associated with Coxsackie viruses. Other general topics covered included a critical evaluation of Paediatric Accident and Emergency viral infections, multimodality imaging of viral infections in children, surgical approaches of otolaryngologists to complex viral infections, new advances in the diagnosis and treatment of viral conjunctivitis and novel molecular diagnostic methods for HPV in childhood. Read More

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http://dx.doi.org/10.3892/etm.2016.3997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348700PMC
February 2017
16 Reads

Chlamydial eye infections: Current perspectives.

Indian J Ophthalmol 2017 Feb;65(2):97-102

Section of Ocular Microbiology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Chlamydia trachomatis, an obligate intraocular bacteria causing trachoma, adult and neonatal inclusion conjunctivitis, was the leading cause of blindness in the last century worldwide. Improvement in socioeconomic and living conditions, availability of antibiotics, and introduction of National Trachoma Control Programmes reduced the prevalence in developed countries, but it persisted in resource-poor settings of Africa and Asia, including India. In 2016, as per the WHO report, trachoma is restricted to 42 countries, causing blindness/visual impairment in ~1. Read More

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http://dx.doi.org/10.4103/ijo.IJO_870_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381307PMC
February 2017
1 Read

Probability of vertical transmission of estimated from national registry data.

Sex Transm Infect 2017 09 21;93(6):416-420. Epub 2017 Feb 21.

Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Objectives: colonisation is common in pregnant women, and it has been claimed that mother-to-child transmission may occur in 10%-70% of deliveries. infections are nevertheless rarely encountered in infants in clinical practice. In order to evaluate the reason for this discrepancy, we designed a nationwide study of the vertical transmission. Read More

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http://dx.doi.org/10.1136/sextrans-2016-052884DOI Listing
September 2017
1 Read

[Ocular manifestations of Zika virus: What we do and do not know].

J Fr Ophtalmol 2017 Feb 9;40(2):138-145. Epub 2017 Feb 9.

Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; UMR 1184, Immunologie des infections virales et maladies auto-immunes, commissariat à l'énergie atomique et aux énergies alternatives, Fontenay-aux-Roses, France. Electronic address:

Zika virus (ZIKV) disease outbreak, which was declared by the end of 2015 in Brazil, has become the largest one to date. Being reported in the Americas and in certain islands of the Pacific, it has the potential to spread worldwide. Although ZIKV infections are mostly self-limiting and/or asymptomatic in the healthy adult, they are responsible for devastating congenital neurologic malformations ZIKV (mainly microcephaly) when contracted during the first months of pregnancy. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.01.002DOI Listing
February 2017
6 Reads

Topical treatments for blepharokeratoconjunctivitis in children.

Cochrane Database Syst Rev 2017 02 7;2:CD011965. Epub 2017 Feb 7.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 162 City Road, London, UK, EC1V 2PD.

Background: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia. Read More

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http://dx.doi.org/10.1002/14651858.CD011965.pub2DOI Listing
February 2017
13 Reads