2,007 results match your criteria Conjunctivitis Neonatal


A study of Ophthalmia Neonatorum in the Central Reion of Ghana: Causative Agents and Antibiotic Susceptibility Patterns.

Glob Pediatr Health 2021 28;8:2333794X211019700. Epub 2021 May 28.

Department of Optometry and Vision Science, School of Allied Health Science, University of Cape Coast, Cape Coast, Ghana.

In developing countries such as Ghana, ophthalmia neonatorum (ON) remains a public health concern. This is because of its unknown etiology patterns, the growing concerns of antibiotic resistance strains and the contribution of ON to childhood blindness. This study was therefore conducted to determine the causative agents, risk factors and the antibiotic sensitivity patterns of micro-organisms associated with ON. Read More

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Blocking the prevalence of adenoviral conjunctivitis in premature infants by combined disinfection method.

Jpn J Infect Dis 2021 May 31. Epub 2021 May 31.

Department of Nosocomial Infection Control, Children's Hospital of Fudan University, China.

This study aimed to determine the cause behind the outbreak of nosocomial adenoviral conjunctivitis in the Neonatal Intensive Care Unit (NICU) and the impact of infection control measures. The objectives of the present study include investigation of the hospital-borne infection associated with adenoviral conjunctivitis, analysis of the possible risk factors, setting bundle infection control measures, which were adjusted according to the control effect. The present study also aims to observe the effect of different intervention measures on controlling adenoviral conjunctivitis. Read More

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inhibitory effect of Lam. extracts over and on different stages of the chlamydial life cycle.

Heliyon 2021 May 18;7(5):e06947. Epub 2021 May 18.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Microbiología Clínica, Ciudad Autónoma de Buenos Aires, Argentina.

Chlamydial infections in humans are widely distributed and are responsible for a variety of acute and chronic diseases. Both and can lead to chronic conditions that have been linked to complications and sequelae. This study aimed to develop a culture method in order to detect antichlamydial activity of different extracts obtained from native Argentinian plants used as antimicrobials in local ethnomedicine and to evaluate their inhibitory activity over and growth. Read More

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Safety of topical ophthalmic antibiotics in pregnant women with hordeola, chalazia, blepharitis, or bacterial conjunctivitis: propensity score analyses.

Eye (Lond) 2021 May 25. Epub 2021 May 25.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Objective: To investigate the association between exposure to topical ophthalmic antibiotics during pregnancy and adverse neonatal outcomes.

Methods: In this retrospective cohort study, we identified pregnant women with hordeola, chalazia, blepharitis, or bacterial conjunctivitis from 2005 to 2018 using the Japanese Medical Data Centre Claims Database. From the eligible women, we extracted women who were dispensed no topical antibiotics during the first trimester (non-antibiotic group), women who were dispensed topical fluoroquinolones alone at least once (fluoroquinolone alone group), and women who were dispensed any single type of antibiotic (single-antibiotic group). Read More

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A dermatologic perspective on multisystem inflammatory syndrome in children.

Clin Dermatol 2021 Jan-Feb;39(1):163-168. Epub 2020 Sep 23.

Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York, USA.

As of May 2020, an emerging immune-mediated syndrome mainly affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault, with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 (COVID-19). Read More

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Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy.

Am J Obstet Gynecol 2021 Apr 22. Epub 2021 Apr 22.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX; Department of Obstetrics and Gynecology, Parkland Health and Hospital Systems, Dallas, TX.

Background: Expedited partner therapy for Chlamydia trachomatis has had mixed efficacy in different populations, but limited data exist on the efficacy of the therapy in a pregnant population.

Objective: This study aimed to evaluate the real-world effectiveness of establishing a prenatal expedited partner therapy program in eradicating chlamydia before delivery and to examine the maternal and neonatal outcomes between women who received expedited partner therapy for chlamydia and women who received standard partner referral testing and treatment during pregnancy.

Study Design: An expedited partner therapy program was implemented on August 21, 2019, at a public hospital in a county with high chlamydia prevalence. Read More

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Reducing suspicion of sexual abuse in paediatric chlamydial conjunctivitis using genotyping.

BMJ Case Rep 2021 Mar 29;14(3). Epub 2021 Mar 29.

Ophthalmology, Birmingham Children's Hospital, Birmingham, West Midlands, UK.

is a Gram-negative bacterium that causes urogenital tract infections, and ocular infections including trachoma, neonatal conjunctivitis and adult chlamydial inclusion conjunctivitis. A positive diagnosis in children often raises suspicions of sexual abuse. While outer membrane protein A () genotypes A-C are non-invasive and are associated with trachoma; genotypes D-K are often associated with sexually transmitted urogenital infections or sexually acquired chlamydial conjunctivitis. Read More

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Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.

BMC Infect Dis 2021 Mar 17;21(1):270. Epub 2021 Mar 17.

Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave., Box 49, Brooklyn, NY, 11203, USA.

Background: Neonatal ocular prophylaxis with silver nitrate does not prevent neonatal conjunctivitis due to Chlamydia trachomatis. The efficacy of antibiotic containing preparations for prevention of neonatal chlamydial conjunctivitis (NCC) has not been established.

Objective: To examine published literature to determine whether antibiotic containing preparation are efficacious for prevention of NCC and C. Read More

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One-year Profile of Eye Diseases in Infants (PEDI) in secondary (rural) eye care centers in South India.

Indian J Ophthalmol 2021 04;69(4):906-909

L V Prasad Eye Institute, KAR Campus, Banjara Hills, Hyderabad, Telangana, India.

Purpose: The aim of this study was to report the proportion and patterns of eye diseases observed among infants seen at two rural eye care centers in South India.

Methods: A retrospective review of case records of infants seen between January 1, 2017 and December 31, 2017 at two rural secondary eye care centers attached to L V Prasad Eye Institute, Hyderabad. Data were collected regarding their demographic profile, the pattern of eye problems observed, management at the facility itself, and need for referrals. Read More

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WASH Upgrades for Health in Amhara (WUHA): study protocol for a cluster-randomised trial in Ethiopia.

BMJ Open 2021 02 22;11(2):e039529. Epub 2021 Feb 22.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA

Introduction: Facial hygiene promotion and environmental improvements are central components of the global trachoma elimination strategy despite a lack of experimental evidence supporting the effectiveness of water, sanitation and hygiene (WASH) measures for reducing trachoma transmission. The objective of the WUHA (WASH Upgrades for Health in Amhara) trial is to evaluate if a comprehensive water improvement and hygiene education programme reduces the prevalence of ocular chlamydia infection in rural Africa.

Methods And Analysis: Forty study clusters, each of which had received at least annual mass azithromycin distributions for the 7 years prior to the start of the study, are randomised in a 1:1 ratio to the WASH intervention arm or a delayed WASH arm. Read More

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February 2021

Children as messengers of health knowledge? Impact of health promotion and water infrastructure in schools on facial cleanliness and trachoma in the community.

PLoS Negl Trop Dis 2021 02 1;15(2):e0009119. Epub 2021 Feb 1.

Dana Center for Preventive Ophthalmology, Johns Hopkins University, Baltimore, Maryland, United States of America.

Background: Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Read More

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February 2021

Adverse pregnancy and neonatal outcomes associated with systematic review and meta-analysis.

Sex Transm Infect 2021 03 12;97(2):104-111. Epub 2021 Jan 12.

Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.

Objective: To examine associations between (NG) infection during pregnancy and the risk of preterm birth, spontaneous abortion, premature rupture of membranes, perinatal mortality, low birth weight and ophthalmia neonatorum.

Data Sources: We searched Medline, EMBASE, the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature for studies published between 1948 and 14 January 2020.

Methods: Studies were included if they reported testing for NG during pregnancy and compared pregnancy, perinatal and/or neonatal outcomes between women with and without NG. Read More

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Surveillance of Nosocomial Infections in a Bulgarian Neonatal Intensive Care Unit.

Folia Med (Plovdiv) 2020 Dec;62(4):753-761

Medical University of Plovdiv, Plovdiv, Bulgaria.

Introduction: Nosocomial infections (NI) are frequent complications in neonatal intensive care units (NICU) which result in high morbidity and mortality.

Aim: To determine and analyze the incidence, risk factors and etiologic agents of NI in newborns admitted in the NICU to help plan-ning future surveillance and prevention strategies.

Materials And Methods: A prospective cohort study was carried out at the NICU of St George University Hospital, Plovdiv, Bul-garia from January 1, 2017 to June 31, 2018. Read More

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December 2020

Using Historical Data to Support Approval of Drug Products for Ophthalmia Neonatorum: Innovative Approach Toward Evidence-Based Medicine.

JAMA Ophthalmol 2021 02;139(2):214-217

Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.

Importance: Off-label treatment was common for ophthalmia neonatorum because only erythromycin ointment had been approved by the US Food and Drug Administration (FDA) for this indication. Ophthalmia neonatorum was previously considered a different indication from bacterial conjunctivitis in older children and adults because of uncertain similarities in the cause of disease and the treatment course between the 2 populations. Prospective therapeutic clinical studies were required to demonstrate the effectiveness of treatment for ophthalmia neonatorum. Read More

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February 2021

Using Adult Drug Efficacy Data to Aid in Interpretation of Underpowered Pediatric Studies.

JAMA Ophthalmol 2021 02;139(2):217-218

Department of Ophthalmology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis.

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February 2021

Ophthalmia neonatorum and the role of primary care.

Br J Gen Pract 2020 12 26;70(701):581. Epub 2020 Nov 26.

Sheffield Children's NHS Foundation Trust, Sheffield.

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December 2020

Neonatal meningococcal disease: an update.

J Matern Fetal Neonatal Med 2020 Nov 24:1-6. Epub 2020 Nov 24.

Department of Paediatrics, Patras Medical School, University of Patras , Patras , Greece.

is a common cause of sepsis in the pediatric population but is only rarely observed in neonates. The true incidence of the disease in that age group remains undefined. The purpose of this review is to summarize the published data on meningococcal disease in the neonatal period. Read More

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November 2020

Impact of COVID-19 pandemic, national lockdown, and unlocking on an apex tertiary care ophthalmic institute.

Indian J Ophthalmol 2020 Nov;68(11):2391-2395

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the impact of 2019 COVID-19 pandemic, national lockdown, and unlocking on ophthalmic care provided by the government-funded apex health institute of India.

Methods: Retrospective review of electronic medical records of all patients presenting to the ophthalmology department from March 23, 2020, to July 15, 2020, was compared with that from March 23, 2019, to July 15, 2019. The data between March 23, 2020, to May 31, 2020 (lockdown) and June 06, 2020, to July 15, 2020 (unlock) was compared separately. Read More

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November 2020

Sexually transmitted infections in pregnancy - An update on Chlamydia trachomatis and Neisseria gonorrhoeae.

Eur J Obstet Gynecol Reprod Biol 2020 Dec 8;255:1-12. Epub 2020 Oct 8.

Department of Obstetrics and Gynecology, College of Medicine, University of Lagos, Nigeria. Electronic address:

Routine screening for Chlamydia and gonococcal infection in pregnancy is not widespread, especially in low- and middle-income countries (LMICs), despite their potential adverse consequences on pregnancy outcome. We conducted a systematic literature search of three major databases to review current literature surrounding Chlamydia trachomatis and Neisseria gonorrhoeae infections in pregnancy. We discuss the epidemiology and burden of both infections, detection methods, potential adverse feto-maternal and infant outcomes and provide an overview of treatment options. Read More

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December 2020

Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review.

PLoS Negl Trop Dis 2020 10 2;14(10):e0008612. Epub 2020 Oct 2.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Recent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence.

Methods: We conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a robust diagnosis of ZIKV infection. Read More

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October 2020

Interventions for preventing ophthalmia neonatorum.

Cochrane Database Syst Rev 2020 09 21;9:CD001862. Epub 2020 Sep 21.

Johns Hopkins University, Baltimore, Maryland, USA.

Background: Ophthalmia neonatorum is an infection of the eyes in newborns that can lead to blindness, particularly if the infection is caused by Neisseria gonorrhoeae. Antiseptic or antibiotic medication is dispensed into the eyes of newborns, or dispensed systemically, soon after delivery to prevent neonatal conjunctivitis and potential vision impairment.

Objectives: 1. Read More

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September 2020

Molecular epidemiology of methicillin-susceptible in infants in a neonatal intensive care unit.

Infect Control Hosp Epidemiol 2020 12 16;41(12):1402-1408. Epub 2020 Sep 16.

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo ClinicRochester, Minnesota.

Objective: To investigate the molecular epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in infants in a neonatal intensive care unit (NICU) using whole-genome sequencing.

Design: Investigation of MSSA epidemiology in a NICU.

Setting: Single-center, level IV NICU. Read More

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December 2020

Prophylaxis for ophthalmia neonatorum in Brazil: A snapshot using a multi-professional national survey.

J Neonatal Perinatal Med 2021 ;14(2):203-211

McGill University Health Center, Montreal, Quebec, Canada.

Background: Brazil is a large country with an elevated incidence of Chlamydiatrachomatis (CT) and Neisseriagonorrhoeae (NG) during pregnancy and variable access to health care. The objective of the study was to identify ophthalmia neonatorum prophylaxis practices in the country.

Methods: A prospective multidisciplinary survey was conducted using a closed social media group. Read More

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January 2021

Impact of the COVID-19 Pandemic on Retinopathy of Prematurity Practice: An Indian Perspective.

Indian Pediatr 2020 Oct 5;57(10):979-980. Epub 2020 Sep 5.

Department of Neonatology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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October 2020

Characterization of baseline polybacterial versus monobacterial infections in three randomized controlled bacterial conjunctivitis trials and microbial outcomes with besifloxacin ophthalmic suspension 0.6.

PLoS One 2020 25;15(8):e0237603. Epub 2020 Aug 25.

Clinical Microbiology, Royal University Hospital, Saskatoon, Saskatchewan, Canada.

Background/purpose: To date, studies examining polymicrobial infections in ocular disease have mostly been limited to keratitis or endophthalmitis. We characterized polybacterial infections compared to monobacterial infections in prior clinical studies evaluating besifloxacin ophthalmic suspension 0.6% for the treatment of bacterial conjunctivitis and report on associated microbiological outcomes. Read More

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October 2020

Ophthalmic Corticosteroids in Pregnant Women with Allergic Conjunctivitis and Adverse Neonatal Outcomes: Propensity Score Analyses.

Am J Ophthalmol 2020 12 16;220:91-101. Epub 2020 Jul 16.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: The risks of topical ophthalmic corticosteroids during pregnancy remain unclear. This study investigated the association between exposure to topical ophthalmic corticosteroids during pregnancy and adverse neonatal outcomes.

Design: Retrospective, cohort, database study. Read More

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December 2020

Haemolacria: a case of pseudomembranous conjunctivitis in a neonate.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Adolescent and Child Health, Mater Dei Hospital, Msida, Malta.

We report an unusual case of an 11-day-old neonate presenting with haemolacria on a background of sticky conjunctival discharge. This was secondary to pseudomembranous conjunctivitis which responded well to systemic erythromycin. Early appropriate treatment is important to prevent progression of the ophthalmic infection, which could lead to blindness, and to prevent other manifestations of neonatal chlamydial infection, particularly pneumonia, which could be fatal. Read More

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Pivoting to teleconsultation for paediatric ophthalmology and strabismus: Our experience during COVID-19 times.

Indian J Ophthalmol 2020 Jul;68(7):1387-1391

Child Sight Institute, Jasti V Ramanamma's Children's Eye Care Center, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India.

Purpose: The objective is to analyse and report the data of teleconsultations provided to paediatric ophthalmology and strabismus patients during COVID-19 times and to elaborate our experience for guiding future teleconsultation practices to General, paediatric Ophthalmologists and Strabismologists.

Methods: Retrospective analysis of electronic medical record data of teleconsultations provided in the department of Strabismus, Paediatric and Neuro-ophthalmology was done. Patients with optic nerve related disorders were excluded. Read More

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Epidemiology and Clinical Symptoms Related to Seasonal Coronavirus Identified in Patients with Acute Respiratory Infections Consulting in Primary Care over Six Influenza Seasons (2014-2020) in France.

Viruses 2020 06 10;12(6). Epub 2020 Jun 10.

Laboratoire de Virologie, Université de Corse-Inserm, 20250 UR7310 Corte, France.

There is currently debate about human coronavirus (HCoV) seasonality and pathogenicity, as epidemiological data are scarce. Here, we provide epidemiological and clinical features of HCoV patients with acute respiratory infection (ARI) examined in primary care general practice. We also describe HCoV seasonality over six influenza surveillance seasons (week 40 to 15 of each season) from the period 2014/2015 to 2019/2020 in Corsica (France). Read More

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