1,918 results match your criteria Conjunctivitis Neonatal


Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017.

Emerg Infect Dis 2019 May;25(5):972-975

We characterized a case of neonatal conjunctivitis in New York, USA, caused by Neisseria meningitidis by using whole-genome sequencing. The case was a rare occurrence, and the isolate obtained belonged to an emerging clade (N. meningitidis US nongroupable urethritis) associated with an increase in cases of urethritis since 2015. Read More

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http://dx.doi.org/10.3201/eid2505.181631DOI Listing

Gonococcal ophthalmia neonatorum: a case report.

Med Sante Trop 2018 Nov;28(4):443-445

Institut d'ophtalmologie tropicale de l'Afrique, Bamako, Mali.

A baby born at home 14 hours earlier was brought to the neonatology department with bilateral upper palpebral chemosis with purulent secretions and pseudomembranes, with no general signs of infection. The gram staining of a secretion sample shows the presence of Neisseria gonorrhoeae. Intramuscular ceftriaxone treatment was initiated, combined with topical application of rifamycin, dexamethasone, and oxytetracycline. Read More

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http://dx.doi.org/10.1684/mst.2018.0844DOI Listing
November 2018
1 Read

Infections in Neonatal Intensive Care Units (NICUs).

Int J Environ Res Public Health 2019 02 20;16(4). Epub 2019 Feb 20.

Department of Health Sciences, University of Genoa, Italy Via Pastore, 1-16132 Genoa, Italy.

belongs to the family Enterobacteriaceae, which is commonly found in water, soil, animals, insects, plants. Although displays relatively low virulence, it causes nosocomial infections and outbreaks in severely immunocompromised or critically ill patients, particularly in settings such as intensive care units (ICUs), especially neonatal units (NICUs). This microorganism gives rise to a wide range of clinical manifestations in newborns: from asymptomatic colonization to keratitis, conjunctivitis, urinary tract infections, pneumonia, surgical wound infections, sepsis, bloodstream infection and meningitis. Read More

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http://dx.doi.org/10.3390/ijerph16040610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406414PMC
February 2019
1 Read

Zika virus infection in pregnant women in a General Hospital of Veracruz, Mexico.

J Matern Fetal Neonatal Med 2019 Mar 1:1-5. Epub 2019 Mar 1.

b Subdirección de enseñanza e investigación , Hospital Regional de Alta Especialidad de Oaxaca , Oaxaca , México.

Objectives: To characterize the symptomatology of the patients affected by the Zika virus and to determine the incidence of congenital syndrome due to Zika in pregnant women in the city of Veracruz, Mexico.

Methods: Descriptive, retrospective, and longitudinal study. All the patients in gestation period who attended the general hospital from 1 August to 30 November, 2016 and who met the criterion of suspected case of Zika virus infection. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582627DOI Listing

Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement.

JAMA 2019 Jan;321(4):394-398

Tufts University, Medford, Massachusetts.

Importance: In the United States, the rate of gonococcal ophthalmia neonatorum was an estimated 0.4 cases per 100 000 live births per year from 2013 to 2017. Gonococcal ophthalmia neonatorum can cause corneal scarring, ocular perforation, and blindness as early as 24 hours after birth. Read More

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http://dx.doi.org/10.1001/jama.2018.21367DOI Listing
January 2019
2 Reads

Prevention of Gonococcal Eye Infection in Newborns.

Authors:
Jill Jin

JAMA 2019 01;321(4):414

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http://dx.doi.org/10.1001/jama.2018.21434DOI Listing
January 2019
1 Read

Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

JAMA 2019 01;321(4):404-406

Kaiser Permanente Research Affiliates Evidence-based Practice Center, Kaiser Permanente Center for Health Research, Portland, Oregon.

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http://dx.doi.org/10.1001/jama.2018.17847DOI Listing
January 2019
2 Reads

Ophthalmia Neonatorum.

Authors:
Aik-Kah Tan

N Engl J Med 2019 Jan;380(2):e2

Normah Medical Specialist Center, Kuching, Malaysia

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http://dx.doi.org/10.1056/NEJMicm1808613DOI Listing
January 2019

[Right treatment of red eyes - prescription of topical antibiotics for infectious conjunctivitis is still common in Sweden].

Authors:
Tomas Bro

Lakartidningen 2018 12 17;115. Epub 2018 Dec 17.

Region Jönköpings län - Ögonmottagningen Höglandssjukhuset Eksjö, Sweden Region Jönköpings län - Ögonmottagningen Höglandssjukhuset Eksjö, Sweden.

Conjunctivitis is one of the most common ophthalmologic conditions in general medical practice. In most cases, it is self-limiting and do not require topical antibiotic therapy. In a retrospective, observational cohort study during 2013-2017 in a region in Sweden conjunctivitis was diagnosed in 32 000 cases in primary care. Read More

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December 2018
2 Reads

The newborn conjunctival flora at the post delivery 24 hours.

J Curr Ophthalmol 2018 Dec 10;30(4):348-352. Epub 2018 Apr 10.

Department of Microbiology, Kayseri Training and Education Hospital, Kayseri, Turkey.

Purpose: The aim of this study was to investigate the aerobic conjunctival flora of neonates and the effects of delivery type on conjunctival flora development in neonates who were born with normal spontaneous vaginal delivery (SVD) or elective caesarean section (C/S) and who were not given prophylactic antibiotic eye drops after birth.

Methods: This cross-sectional study included 95 healthy newborns. One day after the delivery, conjunctival samples were taken from newborns who were born with normal SVD or elective C/S, and not given prophylactic antibiotic eye drops after birth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24522325173014
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http://dx.doi.org/10.1016/j.joco.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276619PMC
December 2018
16 Reads

Neonatal conjunctivitis in the New Zealand Midland region.

N Z Med J 2018 Nov 30;131(1486):9-17. Epub 2018 Nov 30.

Ophthalmologist, Clinical Senior Lecturer, Ophthalmology Department, Department of Medicine, Hauora Tairawhiti, University of Otago, Gisborne.

Aims: To assess the incidence of chlamydial and gonorrhoeal neonatal conjunctivitis (CON and GON), across six district health boards in the greater Midland region of New Zealand.

Methods: All positive nucleic acid amplification test (NAAT) eye swabs for Chlamydia trachomatis and NAAT and bacterial eye swabs for Neisseria gonorrhoeae in infants under one year of age were retrieved from three laboratories from 2013-2016. Incidence density rates were calculated using births information from Statistics New Zealand. Read More

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November 2018
25 Reads

Neonatal Conjunctivitis Caused by Neisseria cinerea: A Case of Mistaken Identity.

J Pediatric Infect Dis Soc 2018 Nov 21. Epub 2018 Nov 21.

Division of Pediatric Infectious Diseases, Department of Pediatrics, NYU Winthrop Hospital, Mineola, New York.

We report a case of a 3-day-old boy with Neisseria cinerea conjunctivitis, originally misidentified as Neisseria gonorrhoeae conjunctivitis. Neonates are at increased risk for disseminated gonococcal infection, and physicians should be cognizant of N cinerea and its potential to be mistaken for N gonorrhoeae. Read More

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http://dx.doi.org/10.1093/jpids/piy116DOI Listing
November 2018
19 Reads

Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea.

Int J Environ Res Public Health 2018 11 14;15(11). Epub 2018 Nov 14.

Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon 440-746, Korea.

Enterovirus diseases are fecal-orally transmitted, and its transmission may be closely related with the drinking water quality and other environmental factors. This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. Read More

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http://www.mdpi.com/1660-4601/15/11/2551
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http://dx.doi.org/10.3390/ijerph15112551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266091PMC
November 2018
13 Reads

A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices.

Med Sci Monit 2018 Nov 10;24:8042-8047. Epub 2018 Nov 10.

Psychiatric Hospital "Sveti Ivan", Zagreb, Croatia.

BACKGROUND Ophthalmia neonatorum, or neonatal conjunctivitis, is an acute infection that occurs within the first 28 days of life. This aim of this survey was to evaluate the current methods of preventive treatment for ophthalmia neonatorum in maternity hospitals in Croatia. MATERIAL AND METHODS The annual hospital birth rate in Croatia is approximately 40,000. Read More

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https://www.medscimonit.com/abstract/index/idArt/910705
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http://dx.doi.org/10.12659/MSM.910705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240167PMC
November 2018
6 Reads

Serratia marcescens outbreak in a neonatology unit of a Spanish tertiary hospital: Risk factors and control measures.

Am J Infect Control 2019 Mar 2;47(3):271-279. Epub 2018 Nov 2.

Department of Preventive Medicine, La Paz University Hospital, Madrid, Spain.

Background: We describe the investigation undertaken and the measures adopted to control a Serratia marcescens outbreak in the neonatology unit of La Paz University Hospital in Madrid, Spain.

Methods: Weekly rectal and pharyngeal screenings for S marcescens were performed in the neonates starting after detection of the outbreak. Environmental samples and samples from health care workers (HCWs) were obtained for microbiological analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553183090
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http://dx.doi.org/10.1016/j.ajic.2018.08.026DOI Listing
March 2019
18 Reads

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease.

Front Microbiol 2018 8;9:2422. Epub 2018 Oct 8.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.

Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot, and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by EVs of the family including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10, and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02422
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http://dx.doi.org/10.3389/fmicb.2018.02422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186807PMC
October 2018
19 Reads

Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study.

PLoS One 2018 18;13(10):e0205814. Epub 2018 Oct 18.

Bausch + Lomb, Rochester, New York, United States of America.

The Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study evaluates in vitro antibiotic resistance among Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae isolates from ocular infections. Here we report resistance rates and trends among conjunctival-sourced ocular isolates collected across the US from 2009 through 2016. A total of 1198 conjunctival isolates (483 S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193682PMC
March 2019
3 Reads

Identifying a sufficient core group for trachoma transmission.

PLoS Negl Trop Dis 2018 10 8;12(10):e0006478. Epub 2018 Oct 8.

F.I. Proctor Foundation, University of California San Francisco, San Francisco, CA, United States of America.

Background: In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006478
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http://dx.doi.org/10.1371/journal.pntd.0006478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175502PMC
October 2018
10 Reads

Investigation of an outbreak caused by antibiotic-susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway.

Acta Paediatr 2019 Jan 9;108(1):76-82. Epub 2018 Oct 9.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Aim: Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway between April 2016 and April 2017. Read More

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http://dx.doi.org/10.1111/apa.14584DOI Listing
January 2019
1 Read

Feasibility and safety of mass drug coadministration with azithromycin and ivermectin for the control of neglected tropical diseases: a single-arm intervention trial.

Lancet Glob Health 2018 10;6(10):e1132-e1138

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Background: Mass drug administration has made a major contribution to the public health control of several important neglected tropical diseases. For settings with more than one endemic disease, combined mass drug administration has potential practical advantages compared with separate programmes but needs confirmation of feasibility and safety. We undertook a study of mass drug administration in the Solomon Islands for trachoma and scabies control using ivermectin and azithromycin, key drugs in the control of neglected tropical diseases worldwide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X183039
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http://dx.doi.org/10.1016/S2214-109X(18)30397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139784PMC
October 2018
7 Reads

Mass azithromycin distribution for hyperendemic trachoma following a cluster-randomized trial: A continuation study of randomly reassigned subclusters (TANA II).

PLoS Med 2018 08 14;15(8):e1002633. Epub 2018 Aug 14.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.

Background: The World Health Organization recommends annual mass azithromycin administration in communities with at least 10% prevalence of trachomatous inflammation-follicular (TF) in children, with further treatment depending on reassessment after 3-5 years. However, the effect of stopping mass azithromycin distribution after multiple rounds of treatment is not well understood. Here, we report the results of a cluster-randomized trial where communities that had received 4 years of treatments were then randomized to continuation or discontinuation of treatment. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091918PMC
August 2018
25 Reads

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.

J Pediatric Infect Dis Soc 2018 Aug;7(3):e107-e115

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: With the continued high prevalence of chlamydia worldwide and high risk of transfer from mothers to their infant during delivery, a need for safe and effective therapies for infants who acquire a chlamydial infection remains. We conducted a systematic review and meta-analysis of antibiotic treatments, including oral erythromycin, azithromycin, and trimethoprim, for neonatal chlamydial conjunctivitis.

Methods: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to July 14, 2017. Read More

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http://dx.doi.org/10.1093/jpids/piy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097578PMC
August 2018
8 Reads

Kawasaki Disease in the neonate: case report and literature review.

Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. Epub 2018 Jul 3.

Division of Rheumatology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5980 University Ave, Halifax, NS, B3K 6R8, Canada.

Background: Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD.

Case Presentation: A previously healthy full term 15 day old Caucasian male with an unremarkable antenatal and perinatal history, presented on Day 2 of illness with fever, rash, irritability, and poor feeding. Read More

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http://dx.doi.org/10.1186/s12969-018-0263-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029347PMC
July 2018
4 Reads

Dynamics of allergy development during the first 5 years of life.

Eur J Pediatr 2018 Sep 22;177(9):1317-1325. Epub 2018 Jun 22.

Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic.

Allergic diseases have increased in developed countries during the past decades. A cohort of Slovak children was followed from birth to track allergic symptoms dynamics in early childhood. Information on allergic symptoms (atopic dermatitis = AD, rhino conjunctivitis = RC, wheezing = Wh, urticaria = Ur) and food allergies among children was based on clinical evaluation of children by allergists at three developmental stages (infant, toddler, preschool). Read More

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http://dx.doi.org/10.1007/s00431-018-3188-9DOI Listing
September 2018
6 Reads

Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study.

Acta Ophthalmol 2018 Dec 9;96(8):789-794. Epub 2018 Jun 9.

Lysningen Research Center, Trekroner, Denmark.

Purpose: Acute infectious conjunctivitis is a common disease. While usually self-limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0-4 years in Denmark, Norway and Sweden. Read More

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http://dx.doi.org/10.1111/aos.13813DOI Listing
December 2018
6 Reads

Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project.

Environ Health Perspect 2018 04 12;126(4):047005. Epub 2018 Apr 12.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear.

Objectives: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence.

Methods: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Read More

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http://dx.doi.org/10.1289/EHP2738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071724PMC
April 2018
58 Reads

Case 1: Eye Discharge in a 10-day-old Neonate Born by Cesarean Delivery.

Pediatr Rev 2018 Apr;39(4):210

Department of Pediatrics, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1542/pir.2016-0090DOI Listing
April 2018
2 Reads

Optimizing Accessibility of a Hand-wash Gel to Infant's Cradle: Effect on Neonatal Conjunctivitis.

Pediatr Infect Dis J 2019 Jan;38(1):e7-e11

Department of Neonatology.

Background: In our recent study in 2015, we showed a significant relationship between increased rate of clinical neonatal conjunctivitis (CNC) and performance of eye red reflex examination. Our study aim was to assess whether improved accessibility of staff to disinfectant gel (via attaching the gel bottle to infant's cradle) will increase the caring staff compliance with hand hygiene and decrease the rate of CNC.

Methods: Our intervention included attaching bottles of alcohol-based gel to newborns' cradles to ensure full availability and accessibility of hand-wash disinfectant. Read More

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http://dx.doi.org/10.1097/INF.0000000000002023DOI Listing
January 2019
3 Reads

Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013.

BMC Infect Dis 2018 03 20;18(1):135. Epub 2018 Mar 20.

Beijing Center for Disease Prevention and Control, No.16, Hepingli Middle Road, Beijing, 100013, People's Republic of China.

Background: Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China. However, little is known about the epidemiology and type distribution of acute adenoviral conjunctivitis in Beijing.

Methods: Acute conjunctivitis surveillance was conducted in 18 hospitals in Beijing from July through October during 2011-2013. Read More

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http://dx.doi.org/10.1186/s12879-018-3014-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859447PMC
March 2018
10 Reads
2.610 Impact Factor

Update: Noncongenital Zika Virus Disease Cases - 50 U.S. States and the District of Columbia, 2016.

MMWR Morb Mortal Wkly Rep 2018 Mar 9;67(9):265-269. Epub 2018 Mar 9.

Zika virus is a flavivirus primarily transmitted to humans by Aedes aegypti mosquitoes (1). Zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). Most Zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or nonpurulent conjunctivitis; Guillain-Barré syndrome, meningoencephalitis, and severe thrombocytopenia rarely have been associated with Zika virus infection (1). Read More

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http://dx.doi.org/10.15585/mmwr.mm6709a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844284PMC
March 2018
22 Reads

Diagnosis of a neonatal ophthalmic discharge, Ophthalmia neonatorum, in the molecular age: investigation for a correct therapy.

J Biol Regul Homeost Agents 2018 Jan-Feb;32(1):177-184

Department of Medical, Oral, and Biotechnological Sciences; “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy.

An early double case of acute Ophthalmia neonatorum in 3-day-old twins is reported. Culture of eye swabs showed a wide bacterial polymorphism, in which common bacteria, such as Klebsiella pneumoniae, Streptococcus pneumoniae, Corynebacterium ulcerans and other Enterobacteriaceae, coexisted with atypical Mycoplasmataceae and Chlamydiaceae from resident cervical-vaginal maternal microbiota. The neonates were in an apparently healthy state, but showed red eyes with abundant greenish-yellow secretion, mild chemosis and lid edema. Read More

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April 2018
7 Reads

Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia.

PLoS Negl Trop Dis 2018 02 16;12(2):e0006270. Epub 2018 Feb 16.

Trachoma Control Program, The Carter Center, Atlanta, Georgia, United States of America.

Background: Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiveness of MDA programs, yet published reports from trachoma programs are rare. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833287PMC
February 2018
13 Reads

Clinical Age-Specific Seasonal Conjunctivitis Patterns and Their Online Detection in Twitter, Blog, Forum, and Comment Social Media Posts.

Invest Ophthalmol Vis Sci 2018 02;59(2):910-920

Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California, United States.

Purpose: We sought to determine whether big data from social media might reveal seasonal trends of conjunctivitis, most forms of which are nonreportable.

Methods: Social media posts (from Twitter, and from online forums and blogs) were classified by age and by conjunctivitis type (allergic or infectious) using Boolean and machine learning methods. Based on spline smoothing, we estimated the circular mean occurrence time (a measure of central tendency for occurrence) and the circular variance (a measure of uniformity of occurrence throughout the year, providing an index of seasonality). Read More

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http://dx.doi.org/10.1167/iovs.17-22818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815847PMC
February 2018
8 Reads

Impact of Water, Sanitation and Hygiene Interventions on Growth, Non-diarrheal Morbidity and Mortality in Children Residing in Low- and Middle-income Countries: A Systematic Review.

Indian Pediatr 2018 May 9;55(5):381-393. Epub 2018 Feb 9.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research; New Delhi, India. Correspondence to: Dr Harshpal Singh Sachdev, Senior Consultant, Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India.

Objective: To evaluate the impact of water, sanitation and hygiene (WASH) interventions in children (age <18 y) on growth, non-diarrheal morbidity and mortality in children.

Design: Systematic review of randomized controlled trials, non-randomized controlled trials and controlled before-after studies.

Setting: Low- and middle-income countries. Read More

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May 2018
42 Reads

[What about tropical endemic vernal keratoconjunctivitis? Which relationship with intestinal parasites?]

J Fr Ophtalmol 2018 Feb 1;41(2):152-157. Epub 2018 Feb 1.

Faculté de médecine et de sciences biomédicales, université de Yaoundé I, Yaoundé, Cameroun.

Given the causative parasite hypothesis for tropical endemic limbo-conjunctivitis (TELC), we conducted an analytical case-control study of all children with tropical endemic limbo-conjunctivitis seen in the ophthalmology department of Laquintinie hospital in Douala during the period from January 2nd to April 30, 2015.

Results: We identified 64 cases of tropical endemic limbo-conjunctivitis out of 550 children seen; a hospital prevalence of 11.6%; thirteen cases (eight boys and five girls) did not meet inclusion criteria, and 51 cases were included, 31 boys (60. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.08.006DOI Listing
February 2018

Bacterial Conjunctivitis in Childhood: Etiology, Clinical Manifestations, Diagnosis, and Management.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):120-127

Department of Family Medicine, The University of Calgary, Calgary, Alberta, Canada.

Background: Bacterial conjunctivitis is a common reason for children to be seen in pediatric practices. A correct diagnosis is important so that appropriate treatment can be instituted.

Objective: To provide an update on the evaluation, diagnosis, and treatment of bacterial conjunctivitis in children. Read More

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http://dx.doi.org/10.2174/1872213X12666180129165718DOI Listing
December 2018
6 Reads

[Tarsal Kink: Pathognomonic Presentation and Therapy of a Rare Congenital Upper Eyelid Malformation].

Klin Monbl Augenheilkd 2018 Jan 26;235(1):34-38. Epub 2018 Jan 26.

Augenheilkunde, AK Barmbek, Hamburg.

Background: Presentation of a congenital abnormality that is rare, but follows a distinct course and can be diagnosed and cured promptly if the pathognomonic presentation is recognized. A congenital tarsal kink leads to a malposition of the upper eyelid margin that must not be missed, as it will lead to ulcerative keratitis if it is not treated.

Case Presentation: An otherwise healthy newborn was presented after delivery with forceps with marked unilateral purulent secretion and blepharospasm. Read More

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http://dx.doi.org/10.1055/s-0043-125335DOI Listing
January 2018
3 Reads

Aetiology of neonatal conjunctivitis evaluated in a population-based setting.

Acta Paediatr 2018 May 6;107(5):774-779. Epub 2018 Feb 6.

Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Aim: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population-based setting.

Methods: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010-2015. Conjunctival specimens were collected from 167 neonates for multiplex polymerase chain reaction to detect 16 respiratory viruses, from 163 for polymerase chain reaction to detect Chlamydia trachomatis and Neisseria gonorrhoeae and from 160 for bacterial culture studies. Read More

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http://dx.doi.org/10.1111/apa.14227DOI Listing
May 2018
5 Reads

Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial.

BMC Infect Dis 2017 12 28;17(1):799. Epub 2017 Dec 28.

London School of Hygiene and Tropical Medicine, London, UK.

Background: Vertical transmission can result in neonatal infection and disease. Reducing the transmission of bacterial pathogens from mother to infant may be an effective means of preventing neonatal infection, including bacterial conjunctivitis.

Methods: In a double-blind, randomized trial, we assessed the effect of administering a single dose of oral azithromycin to women in labour on bacterial colonization of the neonate. Read More

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http://dx.doi.org/10.1186/s12879-017-2909-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746019PMC
December 2017
13 Reads

The eyes have it: An unusual case of ophthalmia neonatorum or a shifting landscape?

SAGE Open Med Case Rep 2017 11;5:2050313X17745905. Epub 2017 Dec 11.

Division of Pediatric Hospital Medicine, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.

Despite dramatic declines in the incidence of ophthalmia neonatorum with universal prophylaxis, it remains a clinically important cause of eye disease in newborns. While clear guidelines exist for the treatment of the historically primary agents of ophthalmia neonatorum ( and ), it is less clear how to manage newborns with conjunctivitis secondary to other bacterial organisms, particularly those also frequently implicated in neonatal sepsis. We present the case of a 3-day-old well-appearing term infant with unilateral purulent conjunctivitis. Read More

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http://dx.doi.org/10.1177/2050313X17745905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734447PMC
December 2017
10 Reads

The association between a genetic risk score for allergy and the risk of developing allergies in childhood-Results of the WHISTLER cohort.

Pediatr Allergy Immunol 2018 02 22;29(1):72-77. Epub 2017 Nov 22.

Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.

Background: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.

Methods: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. Read More

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http://doi.wiley.com/10.1111/pai.12824
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http://dx.doi.org/10.1111/pai.12824DOI Listing
February 2018
10 Reads

A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China.

BMC Ophthalmol 2017 Sep 26;17(1):174. Epub 2017 Sep 26.

Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, 6400 Freret Street, New Orleans, LA, 70118, USA.

Background: The aim of the project is to retrospectively study the changes in bacterial pathogens in acute neonatal bacterial conjunctivitis from 2002 to 2016 in Southern China. The results may provide the guidance for drug choice for acute neonatal bacterial conjunctivitis.

Methods: Secretion specimens for bacterial culture were taken from 485 cases with clinically diagnosed acute bacterial neonatal conjunctivitis. Read More

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http://dx.doi.org/10.1186/s12886-017-0570-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615761PMC
September 2017
8 Reads

Interventions for treating genital Chlamydia trachomatis infection in pregnancy.

Cochrane Database Syst Rev 2017 09 22;9:CD010485. Epub 2017 Sep 22.

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch University and Tygerberg Hospital, PO Box 19063, Tygerberg, Western Cape, South Africa, 7505.

Background: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia. Read More

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http://dx.doi.org/10.1002/14651858.CD010485.pub2DOI Listing
September 2017
21 Reads

Treatment of plasminogen deficiency patients with fresh frozen plasma.

Pediatr Blood Cancer 2018 Feb 6;65(2). Epub 2017 Sep 6.

Department of Pediatric Hematology-Oncology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Congenital plasminogen (Plg) deficiency leads to the development of ligneous membranes on mucosal surfaces. Here, we report our experience with local and intravenous fresh frozen plasma (FFP). We retrospectively reviewed medical files of 17 patients and their eight first-degree relatives. Read More

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http://dx.doi.org/10.1002/pbc.26779DOI Listing
February 2018
6 Reads

Population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the Casamance region of Senegal.

BMC Public Health 2017 07 26;18(1):62. Epub 2017 Jul 26.

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.

Background: Trachoma, caused by ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. We conducted the first population-based trachoma prevalence survey in the Casamance region of Senegal to enable the Senegalese National Eye Care Programme (NECP) to plan its trachoma control activities. The World Health Organization (WHO) guidelines state that any individual with trachomatous trichiasis (TT) should be offered surgery, but that surgery should be prioritised where the prevalence is >0. Read More

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http://dx.doi.org/10.1186/s12889-017-4605-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530574PMC
July 2017
42 Reads

Prevention of Ophthalmia Neonatorum Caused by Using a Fatty Acid-Based Formulation.

MBio 2017 07 25;8(4). Epub 2017 Jul 25.

School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom

Ophthalmia neonatorum, also called neonatal conjunctivitis, acquired during delivery can occur in the first 28 days of life. Commonly caused by the bacterial pathogen , infection can lead to corneal scarring, perforation of the eye, and blindness. One approach that can be taken to prevent the disease is the use of an ophthalmic prophylaxis, which kills the bacteria on the surface of the eye shortly after birth. Read More

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http://dx.doi.org/10.1128/mBio.00534-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527305PMC
July 2017
25 Reads

Management of Extraocular Infections.

Indian J Pediatr 2017 Dec 14;84(12):945-952. Epub 2017 Jul 14.

Cornea & Refractive Services, Aravind Eye Hospital & PG Institute of Ophthalmology, 1, Anna Nagar, Madurai, Tamil Nadu, 625 020, India.

Extraocular infection is a frequently encountered problem in children including neonates and infants. Prompt recognition of the extraocular disease and management at first contact reduces the ocular morbidity and visual impairment. Delay in administering appropriate therapy and referral to an eye care personnel may result in blindness; sometimes bilateral, due to severe ophthalmia neonatorum. Read More

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http://dx.doi.org/10.1007/s12098-017-2409-yDOI Listing
December 2017
17 Reads

Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary.

J Med Microbiol 2017 Jul 10;66(7):915-918. Epub 2017 Jul 10.

4​Femicare Clinical Research for Women, Tienen, Belgium 5​Department of Obstetrics and Gynecology, University Hospital Antwerp, Edegem, Belgium.

The objective of the present study was to determine the frequency and age distribution of different Chlamydia trachomatis (CT) genotypes causing ophthalmia neonatorum (ON) in Hungary. Using CT specific PCR, we tested 76 conjunctival samples from symptomatic infants up to 3 months old in the National Centre for Epidemiology, Budapest between 2008 and 2016. CT tested positive in 30 of 76 conjunctival samples (39. Read More

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http://dx.doi.org/10.1099/jmm.0.000523DOI Listing
July 2017
13 Reads

Risk factors for measles death: Kyegegwa District, western Uganda, February-September, 2015.

BMC Infect Dis 2017 07 3;17(1):462. Epub 2017 Jul 3.

Uganda Public Health Fellowship Program - Field Epidemiology Track, Kampala, Uganda.

Background: On 18 August 2015, Kyegegwa District reported eight deaths during a measles outbreak to the Uganda Ministry of Health (MoH). We investigated this death cluster to verify the cause, identify risk factors, and inform public health interventions.

Methods: We defined a probable measles case as onset of fever and generalised rash in a Kyegegwa District resident from 1 February - 15 September 2015, plus ≥1 of the following: coryza, conjunctivitis, and cough. Read More

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http://dx.doi.org/10.1186/s12879-017-2558-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496348PMC
July 2017
3 Reads