4,995 results match your criteria Conjunctivitis Allergic


The development of inflammatory arthritis and enthesitis in patients on dupilumab: a case series.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

St. John's Institute of Dermatology, Guy's and St, Thomas' Hospital NHS Trust, Great Maze Pond, London, SE1 9RT.

Dupilumab (Dupixent , Sanofi), a fully human monoclonal antibody that blocks interleukin (IL)-4 and IL-13 signaling, is the first biologic approved in the UK for adult patients with moderate-to-severe atopic dermatitis (AD). In phase III studies, dupilumab was an effective treatment with 44-51% of patients achieving at least 75% improvement in Eczema Area and Severity Index (EASI). To date, dupilumab has been well tolerated; common adverse reactions reported from phase III data include injection-site reactions (8-19%), allergic conjunctivitis (3-19%) and oral herpes (2-5%). Read More

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http://dx.doi.org/10.1111/bjd.18031DOI Listing

Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel.

J Asthma 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Medical Corps, IDF , Israel.

Objectives: Asthma is a multifactorial, heterogeneous, complex and common chronic respiratory disease driven by diverse mechanisms. Although asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. Read More

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http://dx.doi.org/10.1080/02770903.2019.1604743DOI Listing

[MASK (Mobile Airways Sentinel Network). ARIA's comprehensive solution for mobile app for the multimorbidity of allergic rhinitis and asthma].

Rev Alerg Mex 2019 Jan-Mar;66(1):140-146

Médica Sur, Centro de Excelencia en Asma y alergia, Ciudad de México, México.

The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate. MASK (Mobile Airways Sentinel Network) is an integral part of a project that is supported by the European Union against chronic diseases and focused on active and healthy aging. MASK represents the third phase of ARIA (Allergic Rhinitis and its Impact on Asthma), in which, by using a mobile application in a smart device, the objective is to guide the patient in the control of his/her multi-morbidity, AR and/or allergic conjunctivitis (AC) and/or asthma. Read More

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http://dx.doi.org/10.29262/ram.v66i1.578DOI Listing

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

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http://dx.doi.org/10.1159/000498861DOI Listing
April 2019
1 Read

Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018.

PLoS One 2019 18;14(4):e0215528. Epub 2019 Apr 18.

Department of Optometry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Vernal keratoconjunctivitis is a chronic bilateral severe form of allergic conjunctivitis which affects normal activities in school/work. It is a severe form of allergies in warm and dry tropical and sub-tropical countries. Its prevalence in Ethiopia ranges from 5. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215528PLOS
April 2019
2 Reads

Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

J Affect Disord 2019 Apr 9;252:60-67. Epub 2019 Apr 9.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, 542 No.161, Yu-Pin Rd, Caotun Township, Nantou, Taiwan, R.O.C.. Electronic address:

Background: Studies have reported an association between allergy and panic disorder. However, few studies have explored the relationship between allergic rhinitis and panic disorder. Previous studies were limited by cross-sectional study designs, self-reported symptoms, absence of matched controls, and lack of consideration of the influence of steroid and comorbidities. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.037DOI Listing
April 2019
1 Read

Mobile technology offers novel insights on control and treatment of allergic rhinitis. The MASK study.

J Allergy Clin Immunol 2019 Apr 2. Epub 2019 Apr 2.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France; INSERM U 1168, VIMA : Ageing and chronic diseases Epidemiological and public health approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France and Euforea, Brussels, Belgium. Electronic address:

Background: Mobile health may be used to generate innovative insights into optimizing treatment to improve allergic rhinitis control.

Objectives: A cross-sectional real world observational study was undertaken in 22 countries to complement a pilot study and bring novel information on medication use, disease control and work productivity in everyday life of patients with allergic rhinitis.

Methods: A mobile phone app (Allergy Diary, freely available Google Play and Apple stores) was used to collect data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all allergy medications (prescribed and over-the-counter (OTC)) customized for 22 countries. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.053DOI Listing
April 2019
8 Reads
11.476 Impact Factor

Topical Tacrolimus for Chronic Allergic Conjunctival Disease with and without Atopic Dermatitis.

Curr Eye Res 2019 Apr 5:1-10. Epub 2019 Apr 5.

k Okamoto Eye Clinic , Ehime , Japan.

Purpose/Aim: This study evaluated the efficacy of topical 0.1% tacrolimus ophthalmic suspension for treating chronic allergic conjunctival disease with and without atopic dermatitis.

Materials And Methods: This study was conducted as a prospective observational post-market survey. Read More

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http://dx.doi.org/10.1080/02713683.2019.1600197DOI Listing
April 2019
1 Read

Shortened up-dosing with sublingual immunotherapy drops containing tree allergens is well tolerated and elicits dose-dependent clinical effects during the first pollen season.

World Allergy Organ J 2019 8;12(2):100012. Epub 2019 Mar 8.

Bencard Allergie GmbH, Munich, Germany.

Background: This study compared a rapid home-based up-dosing schedule for sublingual immunotherapy (SLIT) drops containing tree pollen allergens with two previously established schedules. Furthermore, the clinical effect of the SLIT was investigated with respect to patients' first pollen season under treatment.

Methods: In this open-label, prospective, patient-preference, non-interventional study, local and systemic reactions were compared between three up-dosing groups using a SLIT formulation containing birch, alder, and hazel pollen extracts (ORALVAC Compact ). Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439405PMC
March 2019
1 Read

Management of ocular allergy.

Allergy 2019 Mar 19. Epub 2019 Mar 19.

CHU Estaing, Unité d'Allergologie de l'Enfant CHU Estaing 63003 Clermont-Ferrand Cedex1, France.

The treatment and management of ocular allergy (OA) remains a major concern for different specialties, including allergists, ophthalmologists, primary care physicians, rhinologists, pediatricians, dermatologists, clinical immunologists and pharmacists. We performed a systematic review of all relevant publications in Medline, SCOPUS and WebScience including systematic reviews and meta-analysis. Publications were considered relevant if they addressed treatments, or management strategies of OA. Read More

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http://dx.doi.org/10.1111/all.13786DOI Listing
March 2019
6 Reads

Corrigendum to "Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression" [EBioMedicine 28 (2018) 274-286].

EBioMedicine 2019 Mar 16;41:717-718. Epub 2019 Mar 16.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan; Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444068PMC
March 2019
1 Read

Safety of cetirizine ophthalmic solution 0.24% for the treatment of allergic conjunctivitis in adult and pediatric subjects.

Clin Ophthalmol 2019 19;13:403-413. Epub 2019 Feb 19.

Eyevance Pharmaceuticals, Fort Worth, TX, USA,

Purpose: The studies reported here aimed to assess the safety and tolerability of cetirizine ophthalmic solution 0.24%, a new topical ophthalmic medication approved by the US Food and Drug Administration for the treatment of ocular itching associated with allergic conjunctivitis.

Patients And Methods: Three clinical studies evaluated cetirizine ophthalmic solution 0. Read More

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http://dx.doi.org/10.2147/OPTH.S186092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387590PMC
February 2019
4 Reads

Bicanalicular Silicone Intubation for the Management of Punctal Stenosis and Obstruction in Patients With Allergic Conjunctivitis.

Ophthalmic Plast Reconstr Surg 2019 Mar 4. Epub 2019 Mar 4.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: To evaluate the use of bicanalicular silicone intubation for the management of punctal stenosis and obstruction in patients with allergic conjunctivitis.

Methods: A retrospective interventional case series of patients with acquired epiphora due to stenotic or obstructed puncta as a result of allergic conjunctivitis was performed. Punctal dilation and bicanalicular silicone intubation were performed in all patients. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001315DOI Listing
March 2019
1 Read

Vitamin D serum levels in children with vernal keratoconjunctivitis and disease control.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419833468

5 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

The aim of this study was to evaluate whether the control of ocular symptoms with cyclosporine or with tacrolimus in eye drops allows to improve sun exposure and therefore serum level of vitamin D (VD; 25OHD), in the more severe forms of vernal keratoconjunctivitis (VKC). Out of 242 children followed for active VKC, 94 were treated with 1% cyclosporine or 0.1% tacrolimus eye drops, while the other 148 with mild VKC did not need to be treated with immunomodulators. Read More

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http://dx.doi.org/10.1177/2058738419833468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407325PMC
March 2019
7 Reads

Dietary intake of fish and ω-3 polyunsaturated fatty acids and physician-diagnosed allergy in Japanese population: The Japan Environment and Children's Study.

Nutrition 2019 May 25;61:194-201. Epub 2018 Nov 25.

Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan; Toyama Regional Center for JECS, University of Toyama, Toyama, Japan.

Objective: Emerging evidence from epidemiologic studies and clinical trials indicates that ω-3 polyunsaturated fatty acids (PUFAs) may have a preventive or therapeutic effect on allergy, although the results remain controversial. The aim of this study was to investigate the association between intake of fish and ω-3 PUFAs with risk for lifetime prevalence of physician-diagnosed allergy in a Japanese population.

Methods: Study participants were 78 621 pregnant women and 42 831 male partners from The Japan Environment and Children's Study. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.010DOI Listing
May 2019
2 Reads

Low Expression of IL-10 in Circulating Bregs and Inverted IL-10/TNF-α Ratio in Tears of Patients with Perennial Allergic Conjunctivitis: A Preliminary Study.

Int J Mol Sci 2019 Feb 27;20(5). Epub 2019 Feb 27.

Department of Immunology and Research Unit, Institute of Ophthalmology "Conde de Valenciana Foundation", 06800 Mexico City, Mexico.

Allergic conjunctivitis (AC) is one of the most common ophthalmological disorders seen in clinical practice. Growing evidence from recent years suggests that a subset of IL-10-expressing B cells is involved in inflammatory allergic diseases. In this study, we aimed to evaluate the potential involvement of blood Bregs cells in perennial allergic conjunctivitis (PAC), and interleukins (IL)-1β, IL-6, IL-8, IL-10, and IL-12, and tumor necrosis factor (TNF)-α, were measured in tear samples and compared with healthy controls (HC) using flow cytometry. Read More

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http://dx.doi.org/10.3390/ijms20051035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429471PMC
February 2019
1 Read

Emerging Therapeutics for Ocular Surface Disease.

Curr Allergy Asthma Rep 2019 Feb 28;19(3):16. Epub 2019 Feb 28.

Yeshiva University, New York, NY, USA.

Purpose Of Review: The purpose of this article is to review treatment advances in ocular allergy that include the treatment of the various signs and symptoms of the allergic inflammatory response of the ocular surface.

Recent Findings: Recent studies have demonstrated improved pharmacological effect of topical agents with artificial tears and cold compresses; brimonidine, a new ophthalmic decongestant which has demonstrated decreased rebound conjunctivitis; and potential use of contact lens and other novel delivery instruments to increase medication retention time. Currently, there have been limited advances in novel ophthalmic treatments. Read More

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http://dx.doi.org/10.1007/s11882-019-0844-8DOI Listing
February 2019
1 Read

Case series of children with steroid-Induced glaucoma.

Malays Fam Physician 2018 31;13(3):32-37. Epub 2018 Dec 31.

Department of Ophthalmology Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur Malaysia.

Steroid-induced glaucoma is the most serious complication of the injudicious use of steroids, particularly among children affected by allergic conjunctivitis. This condition is steroid-dependent, and children are commonly being prescribed topical anti-inflammatories, including topical steroids, by general practitioners. Furthermore, topical steroids are also available over the counter, and this availability contributes to overuse without proper monitoring by an ophthalmologist. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382086PMC
December 2018
1 Read

[Application of corticosteroid eye drops for allergic eye diseases in children].

Orv Hetil 2019 Mar;160(9):329-337

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária u. 39., 1085.

The prevalence of allergic diseases has been increasing recently. Allergy has various symptoms. Allergic eye diseases (seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, giant papillary conjunctivitis, contact blepharoconjunctivitis) are common in atopic patients. Read More

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http://dx.doi.org/10.1556/650.2019.31265DOI Listing
March 2019
2 Reads

The proteolytic effect of mast cell tryptase to eotaxin-1/CCL11·eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by conjunctival fibroblasts.

Jpn J Ophthalmol 2019 Mar 22;63(2):215-220. Epub 2019 Feb 22.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1, Tomioka Urayasu-shi, Chiba, 279-0021, Japan.

Purpose: To investigate the proteolytic effect of mast cell tryptase on eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by conjunctival fibroblasts.

Study Design: Experimental.

Methods: The production of eotaxin-1, -2 and -3 by conjunctival fibroblasts stimulated both with and without IL-4/IL-13 or/and TGF-β was assessed by ELISA. Read More

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http://dx.doi.org/10.1007/s10384-019-00655-wDOI Listing

Multimorbidities of Pediatric Allergic Rhinitis.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):13. Epub 2019 Feb 22.

INGENIO, Immunoal.lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Purpose Of Review: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. Read More

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http://dx.doi.org/10.1007/s11882-019-0843-9DOI Listing
February 2019
2 Reads

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial.

Pediatr Allergy Immunol 2019 Feb 21. Epub 2019 Feb 21.

Hans Christian Andersen Hospital for Children and Adolescents, Odense University Hospital, Odense C, Denmark.

Background: Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization.

Methods: In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. Read More

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http://dx.doi.org/10.1111/pai.13018DOI Listing
February 2019
1 Read

Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
9 Reads

[Aeroallergens causing rhinoconjunctivitis].

Rev Med Chil 2018 Sep;146(9):994-1000

Fundación de Aerobiología, Medioambiente y Salud, Santiago, Chile.

Background: Allergic rhinoconjunctivitis (ARC) has a prevalence of 30% in industrialized countries. For an accurate diagnosis and treatment, it is crucial to identify the causative aeroallergen.

Aim: To evaluate aeroallergen sensitization in adults with ARC in the city of Temuco, Chile. Read More

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http://dx.doi.org/10.4067/s0034-98872018000900994DOI Listing
September 2018
1 Read

Omalizumab for atopic dermatitis: evidence for and against its use.

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Introduction: Omalizumab, has been used for almost two decades, mainly in allergic asthma and chronic spontaneous urticaria for which it is highly beneficial. Smaller studies have evaluated the effects of omalizumab in atopic dermatitis (AD). Current treatments options, such as cyclosporine and azathioprine have limited effect on AD and numerous side effects. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06302-8DOI Listing
February 2019
2 Reads

Utility of Pediatric Allergic Disease Quality of Life Questionnaire for childhood eczema.

Br J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Paediatrics, Kwong Wah Hospital, Hong Kong.

Aim: It is important to objectively evaluate quality of life (QoL) impairment in atopic diseases in children. This study aims to investigate the utility of a Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) in children with eczema.

Methods: PADQLQ, Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score) were compared and correlations evaluated. Read More

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http://doi.wiley.com/10.1111/bjd.17710
Publisher Site
http://dx.doi.org/10.1111/bjd.17710DOI Listing
February 2019
15 Reads

Eye diseases: the neglected health condition among urban slum population of Dhaka, Bangladesh.

BMC Ophthalmol 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

BRAC James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.

Introduction: Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21. Read More

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http://dx.doi.org/10.1186/s12886-019-1043-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357461PMC
January 2019
2 Reads
1.075 Impact Factor

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Int Arch Allergy Immunol 2019 30;178(3):238-247. Epub 2019 Jan 30.

Department of Respiratory Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.

Objective: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models. Read More

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http://dx.doi.org/10.1159/000494932DOI Listing
January 2019
4 Reads

In vitro and in vivo performance of epinastine hydrochloride-releasing contact lenses.

PLoS One 2019 30;14(1):e0210362. Epub 2019 Jan 30.

Department of Ophthalmology, Nihon University, Itabashi, Tokyo, Japan.

A number of drug-releasing contact lenses are currently being studied to address issues inherent in eye drops as a drug delivery method. In this study, we developed epinastine hydrochloride-releasing daily soft contact lenses for treatment of allergic conjunctivitis and examined their in vitro and in vivo performance. Preformed soft contact lenses with/without ionic functional groups were soaked in a solution of epinastine hydrochloride in phosphate-buffered saline to prepare epinastine hydrochloride-releasing soft contact lenses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353132PMC
January 2019
3 Reads

Allergy screening in a schoolchildren-based population.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Background: Schoolchildren screening for allergic diseases may improve early identification and management of atopic children. The aim of this study was to perform a schoolchildren screening program for identification of children with allergic diseases.

Methods: All parents of children attending to 13 primary schools in the city of Rome were requested to fill in a demographic data form and the ChAt questionnaire. Read More

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http://dx.doi.org/10.1111/pai.13024DOI Listing
January 2019
2 Reads

Biological occupational allergy: Protein microarray for the study of laboratory animal allergy (LAA).

AIMS Public Health 2018 9;5(4):352-365. Epub 2018 Oct 9.

Associated Centers for Molecular Allergology, Rome, Italy; Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.

Background: Laboratory Animal Allergy (LAA) has been considered a risk for the workers since 1989 by the NIOSH. About one third of the Laboratory Animal Workers (LAWs) can manifest symptoms to LAA as asthma, rhinitis, conjunctivitis and cutaneous reactions. The prevalence of LAA-induced clinical symptoms has been estimated with a great variability (4-44%) also due to the different methodologies applied. Read More

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http://dx.doi.org/10.3934/publichealth.2018.4.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322995PMC
October 2018
2 Reads

Two differing presentations of periocular dermatitis as a side effect of dupilumab for atopic dermatitis.

Orbit 2019 Jan 10:1-5. Epub 2019 Jan 10.

c Edward S. Harkness Eye Institute , Columbia University Irving Medical Center , New York , NY , USA.

Dupilumab is a monoclonal antibody used to treat atopic dermatitis. Worsening of atopic dermatitis and conjunctivitis following dupilumab use are reported adverse effects; however, there is little reported on the nature and mechanism of these complications. Here, we describe two patients with chronic atopic dermatitis who developed new or severely worsened periocular dermatitis, believed to be a side effect of dupilumab injections, and resolution after its discontinuation. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2018.1
Publisher Site
http://dx.doi.org/10.1080/01676830.2018.1553190DOI Listing
January 2019
5 Reads

Evaluation of the placebo effect in the trials of allergen immunotherapy effectiveness: meta-analysis of randomized and placebo-controlled trials.

Postepy Dermatol Alergol 2018 Dec 13;35(6):620-625. Epub 2018 Nov 13.

Department of Infectious Diseases and Allergology, Military Institute of Medicine, Warsaw, Poland.

Introduction: The total effect of the method of treatment is composed of its specific activity depending on its impact on the disease mechanism and the non-specific activity, i.e. the placebo effect. Read More

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http://dx.doi.org/10.5114/ada.2018.77614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320494PMC
December 2018
2 Reads

Current pharmaceutical developments in atopic dermatitis.

Curr Opin Pharmacol 2019 Jan 2;46:7-13. Epub 2019 Jan 2.

Aarhus University Hospital, Department of Dermatology, Aarhus, Denmark.

Atopic dermatitis (AD) is an inflammatory, pruritic, chronic or chronically relapsing skin disease that typically begins in early childhood and is occurring frequently in families with other atopic diseases (bronchial asthma and/or allergic rhino-conjunctivitis). Thanks to immunological and neurobiological research, the era of new treatments is coming as well as it occurred with psoriasis 15 years ago. Many treatments targeting cytokines (IL-4, IL-13, IL-31, TSLP) or neurotransmitters (substance P, opioids) or their respective receptors as well as phosphodiesterase-4 or the Jak/Stat pathways are under development. Read More

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http://dx.doi.org/10.1016/j.coph.2018.12.003DOI Listing
January 2019
4 Reads

[Reasons for the development of allergies in children].

HNO 2019 Feb;67(2):90-97

Klinik für Hals-Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.

Allergies are one of the most common chronic diseases in childhood, contributing to a tremendous medical and economical burden in health care systems of most industrialized countries. The development of allergies is dependent on a complex interaction of-among others-environmental factors, nutrition, genetic and epigenetic mechanisms as well as the microbiome. These diverse factors can influence early life immune regulation including innate and adaptive immune mechanisms in a complex fashion. Read More

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http://dx.doi.org/10.1007/s00106-018-0595-1DOI Listing
February 2019
12 Reads

[Prevalence of asthma, allergic rhinitis and atopic dermatitis in school children of the Mexican Bajío region].

Rev Alerg Mex 2018 Oct-Dec;65(4):372-378

Universidad Quetzalcóatl en Irapuato, Guanajuato, México.

Background: The prevalence of allergic diseases markedly varies according to the geographical region.

Objective: To determine the prevalence of asthma, allergic rhinitis and atopic dermatitis in children of six and seven years of age.

Methods: Cross-sectional study that included a sample of almost 15 thousand children in five cities of Mexico. Read More

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http://dx.doi.org/10.29262/ram.v65i4.527DOI Listing
January 2019
8 Reads

Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis.

Cornea 2019 Mar;38(3):344-351

Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To investigate the expression of thymic stromal lymphopoietin (TSLP) and the relevant signaling pathways in the giant papillae obtained from patients with vernal keratoconjunctivitis (VKC) and to study the potential functional role and molecular mechanism of TSLP.

Methods: Giant papillae from VKC patients and control samples were used to perform immunohistochemical staining and analyze the mRNA expression of TSLP and related pathway by real-time polymerase chain reaction.

Results: TSLP was markedly expressed in the epithelial cells and some inflammatory cells of giant papillae, but not in the control conjunctival tissue. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001832DOI Listing
March 2019
3 Reads

Phase III trials examining the efficacy of cetirizine ophthalmic solution 0.24% compared to vehicle for the treatment of allergic conjunctivitis in the conjunctival allergen challenge model.

Clin Ophthalmol 2018 13;12:2617-2628. Epub 2018 Dec 13.

Eyevance Pharmaceuticals, TX, USA,

Purpose: The purpose of these Phase III studies was to evaluate the efficacy and safety of cetirizine ophthalmic solution 0.24% compared with vehicle in the treatment of allergen-induced conjunctivitis using the Ora conjunctival allergen challenge (CAC) model.

Methods: The single-center (Study 1) and multi-center (Study 2), double-masked, randomized, vehicle-controlled, parallel group, CAC studies were conducted over ~5 weeks and four study visits. Read More

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http://dx.doi.org/10.2147/OPTH.S185835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296187PMC
December 2018
3 Reads

The Prevalence of Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis and Asthma among Adults of Tehran.

Iran J Public Health 2018 Nov;47(11):1749-1755

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Alteration of environmental factors and air pollution affects the trend of allergic diseases especially in cities such as Tehran. This study aimed to determine the prevalence of allergic rhinitis, conjunctivitis, atopic dermatitis and asthma among adults in the capital city of Iran.

Methods: This cross-sectional study was performed between 2013 and 2016 in Tehran, Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294865PMC
November 2018
1 Read

[Rehabilitation of Anophthalmic Patients with Prosthetic Eyes in Germany Today - Supply Possibilities, Daily Use, Complications and Psychological Aspects].

Klin Monbl Augenheilkd 2019 Jan 19;236(1):54-62. Epub 2018 Dec 19.

Klinik und Poliklinik für Allgemeine Augenheilkunde, Uniklinik Köln, Köln.

Background: A smooth supply with a visually appealing prosthetic eye after enucleation is not just a cosmetic solution, it is also a key factor in successful social and psychological rehabilitation.

Objectives: This article provides an overview of the current state of medical and ocular care regarding prosthetic eyes in Germany. It focuses mainly on the newest clinical results, daily care, complications, and psychological aspects of wearing prosthetic eyes. Read More

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http://dx.doi.org/10.1055/a-0764-4974DOI Listing
January 2019
2 Reads

[Right treatment of red eyes - prescription of topical antibiotics for infectious conjunctivitis is still common in Sweden].

Authors:
Tomas Bro

Lakartidningen 2018 12 17;115. Epub 2018 Dec 17.

Region Jönköpings län - Ögonmottagningen Höglandssjukhuset Eksjö, Sweden Region Jönköpings län - Ögonmottagningen Höglandssjukhuset Eksjö, Sweden.

Conjunctivitis is one of the most common ophthalmologic conditions in general medical practice. In most cases, it is self-limiting and do not require topical antibiotic therapy. In a retrospective, observational cohort study during 2013-2017 in a region in Sweden conjunctivitis was diagnosed in 32 000 cases in primary care. Read More

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December 2018
2 Reads

Allergic Contact Dermatitis, Angioneurotic Edema and Conjunctivitis in a Patient with Autoimmune Thrombocytopenia - A Clinical Case.

Open Access Maced J Med Sci 2018 Nov 21;6(11):2142-2146. Epub 2018 Nov 21.

Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria.

Background: Allergic contact dermatitis (ACD) is common in clinical practice, but the aetiology of this disease is quite varied. A leading pathogenetic mechanism is a cell-mediated immunity. The combinations of ACD with other allergic and systemic autoimmune diseases are relatively rare, but these conditions are undoubtedly a professional challenge for practitioners. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2018.447
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http://dx.doi.org/10.3889/oamjms.2018.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290415PMC
November 2018
13 Reads

[Observation on pollinosis with vegetable food allergy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1779-1783

Department of Allergy, Beijing Shijitan Hospital, Affiliated to Capital Medical University, Beijing, 100038, China.

To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.003DOI Listing
December 2018
10 Reads

NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101.

Biomol NMR Assign 2019 04 12;13(1):127-130. Epub 2018 Dec 12.

Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.

In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Read More

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http://dx.doi.org/10.1007/s12104-018-9864-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439177PMC

Long-Term Efficacy and Dose-Finding Trial of Japanese Cedar Pollen Sublingual Immunotherapy Tablet.

J Allergy Clin Immunol Pract 2019 Apr 8;7(4):1287-1297.e8. Epub 2018 Dec 8.

Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Japanese cedar (JC) pollinosis is a common allergic rhinitis in Japan. The JC pollen sublingual immunotherapy (SLIT) tablet was developed using the highest concentration of JC pollen extract.

Objective: This was a randomized, double-blind, placebo-controlled phase II/III trial to investigate the optimal dose of the JC pollen SLIT tablet and examine long-term efficacy and safety for 3 years with the selected dose, and 2-year follow-up. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.044DOI Listing
April 2019
7 Reads

Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis.

Am J Rhinol Allergy 2019 Mar 6;33(2):137-144. Epub 2018 Dec 6.

3 Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Read More

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http://dx.doi.org/10.1177/1945892418816015DOI Listing
March 2019
6 Reads

IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.

Background: While most studies focus on pro-allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti-inflammatory role and cellular/molecular mechanism of IL-27 in allergic inflammation.

Methods: A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL-27Rα-deficient (WSX-1 ) mice by short ragweed pollen, with untreated or PBS-treated mice as controls. Read More

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http://dx.doi.org/10.1111/all.13691DOI Listing
December 2018
15 Reads

Epicutaneous immunotherapy in rhino-conjunctivitis and food allergies: a review of the literature.

J Transl Med 2018 11 27;16(1):329. Epub 2018 Nov 27.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129, Perugia, Italy.

Background: Epicutaneous immunotherapy (EPIT) is a new way of allergen administration that has a high rate of adherence and safety. The aim of this manuscript is to review clinical trials on EPIT for respiratory and food allergies published in the last 10 years, taking into account how different variables (i.e. Read More

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http://dx.doi.org/10.1186/s12967-018-1701-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260732PMC
November 2018
2 Reads