4,960 results match your criteria Conjunctivitis Allergic


Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
1 Read

Omalizumab for atopic dermatitis: evidence for and against its use.

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Introduction: Omalizumab, has been used for almost two decades, mainly in allergic asthma and chronic spontaneous urticaria for which it is highly beneficial. Smaller studies have evaluated the effects of omalizumab in atopic dermatitis (AD). Current treatments options, such as cyclosporine and azathioprine have limited effect on AD and numerous side effects. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06302-8DOI Listing
February 2019
1 Read

Utility of Pediatric Allergic Disease Quality of Life Questionnaire for childhood eczema.

Br J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Paediatrics, Kwong Wah Hospital, Hong Kong.

Aim: It is important to objectively evaluate quality of life (QoL) impairment in atopic diseases in children. This study aims to investigate the utility of a Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) in children with eczema.

Methods: PADQLQ, Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score) were compared and correlations evaluated. Read More

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http://doi.wiley.com/10.1111/bjd.17710
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http://dx.doi.org/10.1111/bjd.17710DOI Listing
February 2019
5 Reads

Eye diseases: the neglected health condition among urban slum population of Dhaka, Bangladesh.

BMC Ophthalmol 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

BRAC James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.

Introduction: Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21. Read More

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http://dx.doi.org/10.1186/s12886-019-1043-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357461PMC
January 2019
1 Read
1.075 Impact Factor

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Int Arch Allergy Immunol 2019 Jan 30:1-10. Epub 2019 Jan 30.

Department of Respiratory Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.

Objective: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models. Read More

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http://dx.doi.org/10.1159/000494932DOI Listing
January 2019
1 Read

In vitro and in vivo performance of epinastine hydrochloride-releasing contact lenses.

PLoS One 2019 30;14(1):e0210362. Epub 2019 Jan 30.

Department of Ophthalmology, Nihon University, Itabashi, Tokyo, Japan.

A number of drug-releasing contact lenses are currently being studied to address issues inherent in eye drops as a drug delivery method. In this study, we developed epinastine hydrochloride-releasing daily soft contact lenses for treatment of allergic conjunctivitis and examined their in vitro and in vivo performance. Preformed soft contact lenses with/without ionic functional groups were soaked in a solution of epinastine hydrochloride in phosphate-buffered saline to prepare epinastine hydrochloride-releasing soft contact lenses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353132PMC
January 2019
2 Reads

Contact dermatitis to polyacrylamide/C13-4 isoparaffin/laureth-7 mix in an emollient cream for atopic skin.

Contact Dermatitis 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology, University of Montpellier, France.

A 33-year-old female with a history of atopic dermatitis and seasonal rhino-conjunctivitis was referred to investigate eczema. The atopic dermatitis had been active since infancy, then ceased during her teenage years but relapsed starting with the age of 25, mainly on the hands. She reported a recent flare up of inflammatory skin lesions on her chest, arms and face after applying a moisturizing cream to attenuate atopic skin-related dryness on these areas. Read More

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http://dx.doi.org/10.1111/cod.13234DOI Listing
January 2019
3 Reads

Allergy screening in a schoolchildren-based population.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Background: Schoolchildren screening for allergic diseases may improve early identification and management of atopic children. The aim of this study was to perform a schoolchildren screening program for identification of children with allergic diseases.

Methods: All parents of children attending to 13 primary schools in the city of Rome were requested to fill in a demographic data form and the ChAt questionnaire. Read More

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http://dx.doi.org/10.1111/pai.13024DOI Listing
January 2019
1 Read

Biological occupational allergy: Protein microarray for the study of laboratory animal allergy (LAA).

AIMS Public Health 2018 9;5(4):352-365. Epub 2018 Oct 9.

Associated Centers for Molecular Allergology, Rome, Italy; Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.

Background: Laboratory Animal Allergy (LAA) has been considered a risk for the workers since 1989 by the NIOSH. About one third of the Laboratory Animal Workers (LAWs) can manifest symptoms to LAA as asthma, rhinitis, conjunctivitis and cutaneous reactions. The prevalence of LAA-induced clinical symptoms has been estimated with a great variability (4-44%) also due to the different methodologies applied. Read More

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http://dx.doi.org/10.3934/publichealth.2018.4.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322995PMC
October 2018
1 Read

Two differing presentations of periocular dermatitis as a side effect of dupilumab for atopic dermatitis.

Orbit 2019 Jan 10:1-5. Epub 2019 Jan 10.

c Edward S. Harkness Eye Institute , Columbia University Irving Medical Center , New York , NY , USA.

Dupilumab is a monoclonal antibody used to treat atopic dermatitis. Worsening of atopic dermatitis and conjunctivitis following dupilumab use are reported adverse effects; however, there is little reported on the nature and mechanism of these complications. Here, we describe two patients with chronic atopic dermatitis who developed new or severely worsened periocular dermatitis, believed to be a side effect of dupilumab injections, and resolution after its discontinuation. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2018.1
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http://dx.doi.org/10.1080/01676830.2018.1553190DOI Listing
January 2019
4 Reads

Evaluation of the placebo effect in the trials of allergen immunotherapy effectiveness: meta-analysis of randomized and placebo-controlled trials.

Postepy Dermatol Alergol 2018 Dec 13;35(6):620-625. Epub 2018 Nov 13.

Department of Infectious Diseases and Allergology, Military Institute of Medicine, Warsaw, Poland.

Introduction: The total effect of the method of treatment is composed of its specific activity depending on its impact on the disease mechanism and the non-specific activity, i.e. the placebo effect. Read More

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http://dx.doi.org/10.5114/ada.2018.77614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320494PMC
December 2018
1 Read

Current pharmaceutical developments in atopic dermatitis.

Curr Opin Pharmacol 2019 Jan 2;46:7-13. Epub 2019 Jan 2.

Aarhus University Hospital, Department of Dermatology, Aarhus, Denmark.

Atopic dermatitis (AD) is an inflammatory, pruritic, chronic or chronically relapsing skin disease that typically begins in early childhood and is occurring frequently in families with other atopic diseases (bronchial asthma and/or allergic rhino-conjunctivitis). Thanks to immunological and neurobiological research, the era of new treatments is coming as well as it occurred with psoriasis 15 years ago. Many treatments targeting cytokines (IL-4, IL-13, IL-31, TSLP) or neurotransmitters (substance P, opioids) or their respective receptors as well as phosphodiesterase-4 or the Jak/Stat pathways are under development. Read More

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http://dx.doi.org/10.1016/j.coph.2018.12.003DOI Listing
January 2019
3 Reads

[Reasons for the development of allergies in children].

HNO 2019 Feb;67(2):90-97

Klinik für Hals-Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.

Allergies are one of the most common chronic diseases in childhood, contributing to a tremendous medical and economical burden in health care systems of most industrialized countries. The development of allergies is dependent on a complex interaction of-among others-environmental factors, nutrition, genetic and epigenetic mechanisms as well as the microbiome. These diverse factors can influence early life immune regulation including innate and adaptive immune mechanisms in a complex fashion. Read More

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http://dx.doi.org/10.1007/s00106-018-0595-1DOI Listing
February 2019
6 Reads

[Prevalence of asthma, allergic rhinitis and atopic dermatitis in school children of the Mexican Bajío region].

Rev Alerg Mex 2018 Oct-Dec;65(4):372-378

Universidad Quetzalcóatl en Irapuato, Guanajuato, México.

Background: The prevalence of allergic diseases markedly varies according to the geographical region.

Objective: To determine the prevalence of asthma, allergic rhinitis and atopic dermatitis in children of six and seven years of age.

Methods: Cross-sectional study that included a sample of almost 15 thousand children in five cities of Mexico. Read More

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http://dx.doi.org/10.29262/ram.v65i4.527DOI Listing
January 2019
4 Reads

Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis.

Cornea 2019 Mar;38(3):344-351

Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To investigate the expression of thymic stromal lymphopoietin (TSLP) and the relevant signaling pathways in the giant papillae obtained from patients with vernal keratoconjunctivitis (VKC) and to study the potential functional role and molecular mechanism of TSLP.

Methods: Giant papillae from VKC patients and control samples were used to perform immunohistochemical staining and analyze the mRNA expression of TSLP and related pathway by real-time polymerase chain reaction.

Results: TSLP was markedly expressed in the epithelial cells and some inflammatory cells of giant papillae, but not in the control conjunctival tissue. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001832DOI Listing
March 2019
2 Reads

Phase III trials examining the efficacy of cetirizine ophthalmic solution 0.24% compared to vehicle for the treatment of allergic conjunctivitis in the conjunctival allergen challenge model.

Clin Ophthalmol 2018 13;12:2617-2628. Epub 2018 Dec 13.

Eyevance Pharmaceuticals, TX, USA,

Purpose: The purpose of these Phase III studies was to evaluate the efficacy and safety of cetirizine ophthalmic solution 0.24% compared with vehicle in the treatment of allergen-induced conjunctivitis using the Ora conjunctival allergen challenge (CAC) model.

Methods: The single-center (Study 1) and multi-center (Study 2), double-masked, randomized, vehicle-controlled, parallel group, CAC studies were conducted over ~5 weeks and four study visits. Read More

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http://dx.doi.org/10.2147/OPTH.S185835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296187PMC
December 2018
2 Reads

The Prevalence of Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis and Asthma among Adults of Tehran.

Iran J Public Health 2018 Nov;47(11):1749-1755

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Alteration of environmental factors and air pollution affects the trend of allergic diseases especially in cities such as Tehran. This study aimed to determine the prevalence of allergic rhinitis, conjunctivitis, atopic dermatitis and asthma among adults in the capital city of Iran.

Methods: This cross-sectional study was performed between 2013 and 2016 in Tehran, Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294865PMC
November 2018
1 Read

[Rehabilitation of Anophthalmic Patients with Prosthetic Eyes in Germany Today - Supply Possibilities, Daily Use, Complications and Psychological Aspects].

Klin Monbl Augenheilkd 2019 Jan 19;236(1):54-62. Epub 2018 Dec 19.

Klinik und Poliklinik für Allgemeine Augenheilkunde, Uniklinik Köln, Köln.

Background: A smooth supply with a visually appealing prosthetic eye after enucleation is not just a cosmetic solution, it is also a key factor in successful social and psychological rehabilitation.

Objectives: This article provides an overview of the current state of medical and ocular care regarding prosthetic eyes in Germany. It focuses mainly on the newest clinical results, daily care, complications, and psychological aspects of wearing prosthetic eyes. Read More

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http://dx.doi.org/10.1055/a-0764-4974DOI Listing
January 2019
1 Read

Allergic Contact Dermatitis, Angioneurotic Edema and Conjunctivitis in a Patient with Autoimmune Thrombocytopenia - A Clinical Case.

Open Access Maced J Med Sci 2018 Nov 21;6(11):2142-2146. Epub 2018 Nov 21.

Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria.

Background: Allergic contact dermatitis (ACD) is common in clinical practice, but the aetiology of this disease is quite varied. A leading pathogenetic mechanism is a cell-mediated immunity. The combinations of ACD with other allergic and systemic autoimmune diseases are relatively rare, but these conditions are undoubtedly a professional challenge for practitioners. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2018.447
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http://dx.doi.org/10.3889/oamjms.2018.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290415PMC
November 2018
7 Reads

[Observation on pollinosis with vegetable food allergy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1779-1783

Department of Allergy, Beijing Shijitan Hospital, Affiliated to Capital Medical University, Beijing, 100038, China.

To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.003DOI Listing
December 2018
6 Reads

NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101.

Biomol NMR Assign 2018 Dec 12. Epub 2018 Dec 12.

Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.

In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Read More

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http://dx.doi.org/10.1007/s12104-018-9864-xDOI Listing
December 2018

Long-Term Efficacy and Dose-Finding Trial of Japanese Cedar Pollen Sublingual Immunotherapy Tablet.

J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.

Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Japanese cedar (JC) pollinosis is a common allergic rhinitis in Japan. The JC pollen sublingual immunotherapy (SLIT) tablet was developed using the highest concentration of JC pollen extract.

Objective: This was a randomized, double-blind, placebo-controlled phase II/III trial to investigate the optimal dose of the JC pollen SLIT tablet and examine long-term efficacy and safety for 3 years with the selected dose, and 2-year follow-up. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.044DOI Listing
December 2018
6 Reads

Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis.

Am J Rhinol Allergy 2018 Dec 6:1945892418816015. Epub 2018 Dec 6.

3 Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Read More

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http://dx.doi.org/10.1177/1945892418816015DOI Listing
December 2018
2 Reads

IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.

Background: While most studies focus on pro-allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti-inflammatory role and cellular/molecular mechanism of IL-27 in allergic inflammation.

Methods: A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL-27Rα-deficient (WSX-1 ) mice by short ragweed pollen, with untreated or PBS-treated mice as controls. Read More

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http://dx.doi.org/10.1111/all.13691DOI Listing
December 2018
9 Reads

Epicutaneous immunotherapy in rhino-conjunctivitis and food allergies: a review of the literature.

J Transl Med 2018 Nov 27;16(1):329. Epub 2018 Nov 27.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129, Perugia, Italy.

Background: Epicutaneous immunotherapy (EPIT) is a new way of allergen administration that has a high rate of adherence and safety. The aim of this manuscript is to review clinical trials on EPIT for respiratory and food allergies published in the last 10 years, taking into account how different variables (i.e. Read More

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http://dx.doi.org/10.1186/s12967-018-1701-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260732PMC
November 2018
1 Read

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye.

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES143-DES150

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Purpose: Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.17-23467DOI Listing
November 2018
13 Reads

Conurbation, Urban, and Rural Living as Determinants of Allergies and Infectious Diseases: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2016-2017.

JMIR Public Health Surveill 2018 Nov 26;4(4):e11354. Epub 2018 Nov 26.

Royal College of General Practitioners Clinical Innovation and Research Centre, London, United Kingdom.

Background: Living in a conurbation, urban, or rural environment is an important determinant of health. For example, conurbation and rural living is associated with increased respiratory and allergic conditions, whereas a farm or rural upbringing has been shown to be a protective factor against this.

Objective: The objective of the study was to assess differences in general practice presentations of allergic and infectious disease in those exposed to conurbation or urban living compared with rural environments. Read More

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http://publichealth.jmir.org/2018/4/e11354/
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http://dx.doi.org/10.2196/11354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288591PMC
November 2018
9 Reads

Pharmacokinetics of topically applied tacrolimus dissolved in Marinosolv, a novel aqueous eye drop formulation.

Eur J Pharm Biopharm 2019 Jan 19;134:88-95. Epub 2018 Nov 19.

Clinical Department for Farm Animals and Herd Management, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna, Austria.

Corticosteroids and macrolide immunomodulators such as tacrolimus are effective drugs for the topical treatment of inflammatory eye diseases like allergic conjunctivitis or dry eye. However, tacrolimus is practically insoluble in aqueous solutions and is therefore currently formulated as dispersion. This leads to low bioavailability. Read More

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http://dx.doi.org/10.1016/j.ejpb.2018.11.015DOI Listing
January 2019
10 Reads

Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes.

Allergy 2018 Nov 17. Epub 2018 Nov 17.

CINTESIS - Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Refined phenotyping of allergic diseases may unravel novel phenotypes. Conjunctivitis as an independent disorder has never been approached.

Aim: To identify distinct classes of allergic respiratory diseases using latent class analysis (LCA) and distinguish each class using classification and regression tree (CART) analysis. Read More

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http://dx.doi.org/10.1111/all.13670DOI Listing
November 2018
13 Reads

αβ integrin inhibitors: a patent review.

Expert Opin Ther Pat 2018 Dec 22;28(12):903-917. Epub 2018 Nov 22.

c Research Division of Clinical Pharmacology , Τhe First Affiliated Hospital of Nanjing Medical University , Nanjing , China.

Introduction: The αβ integrin is heterodimeric cell surface receptors expressed on most leukocytes. Mucosal addressing cell adhesion molecule 1(MAdCAM-1) is an exclusive ligand for αβ integrin. Areas covered: This article will highlight the progress that has been made in the discovery and development of αβ integrin inhibitors, and their use in the treatment of inflammatory bowel diseases, multiple sclerosis, asthma, hepatic disorders, human immunodeficiency virus, allergic conjunctivitis and type 1 diabetes. Read More

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http://dx.doi.org/10.1080/13543776.2018.1549227DOI Listing
December 2018
11 Reads
4.300 Impact Factor

Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis.

Allergol Int 2018 Nov 9. Epub 2018 Nov 9.

Laboratory of Ocular Atopic Diseases, Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:

Background: To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis.

Methods: The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue. Read More

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http://dx.doi.org/10.1016/j.alit.2018.09.007DOI Listing
November 2018
2 Reads

Involvement of the annexin A1-Fpr anti-inflammatory system in the ocular allergy.

Eur J Pharmacol 2019 Jan 9;842:298-305. Epub 2018 Nov 9.

UNIFESP - Universidade Federal de São Paulo, Departamento de Morfologia e Genética, São Paulo, SP, Brazil. Electronic address:

Annexin A1 (ANXA1)-formyl peptide receptor (Fpr) system is potent effective mediators in the control of the inflammatory response. In this study, we evaluate the potential involvement of the Fpr family in the protective effect of the mimetic peptide of ANXA1 (ANXA1) using an experimental allergic conjunctivitis (AC) model in mice. Ovalbumin (OVA)/Alum-immunized wild-type (WT) and ANXA1-null (ANXA1) Balb/c mice (days 0 and 7) were challenged by eye drops containing OVA on days 14-16, and two groups received ANXA1 alone or with Fpr antagonist Boc2 intraperitoneally during challenged days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183065
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http://dx.doi.org/10.1016/j.ejphar.2018.11.008DOI Listing
January 2019
7 Reads

Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.

Chest 2019 Feb 9;155(2):417-426. Epub 2018 Nov 9.

School of Earth, Society, and Environment, Department of Atmospheric Sciences, University of Illinois, Urbana, IL.

Although air pollution is well known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million COPD deaths can be attributed to air pollution, but air pollution may also account for 19% of all cardiovascular deaths and 21% of all stroke deaths. Read More

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http://dx.doi.org/10.1016/j.chest.2018.10.041DOI Listing
February 2019
16 Reads

First-reported pediatric cases of American ginseng anaphylaxis and allergy.

Allergy Asthma Clin Immunol 2018 3;14:79. Epub 2018 Nov 3.

1Division of Allergy & Immunology, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital, 4480 Oak St., Vancouver, BC V6H3N1 Canada.

Background: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, (Korean or Asian ginseng), and (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients. Read More

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http://dx.doi.org/10.1186/s13223-018-0304-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215653PMC
November 2018
5 Reads

Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses.

FASEB J 2018 Nov 1:fj201801805R. Epub 2018 Nov 1.

Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Allergic conjunctivitis (AC) is one of the most common ocular surface diseases in the world. In AC, T helper type 2 (T2) immune responses play central roles in orchestrating inflammatory responses. However, the roles of lipid mediators in the onset and progression of AC remain to be fully explored. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801805R
Publisher Site
http://dx.doi.org/10.1096/fj.201801805RDOI Listing
November 2018
7 Reads

Efficacy and Tolerability of Ketotifen in the Treatment Of Seasonal Allergic Conjunctivitis: Comparison between Ketotifen 0.025% and 0.05% Eye Drops.

Ocul Immunol Inflamm 2018 Oct 10:1-5. Epub 2018 Oct 10.

a Department of Neuroscience, Ophthalmology Unit , University of Padova , Padova , Italy.

Purpose: To study the tolerability and efficacy of two formulations of topical ketotifen ophthalmic solutions for the treatment of seasonal allergic conjunctivitis (SAC).

Methods: 81 active SAC patients were treated with either ketotifen 0.025% or 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1530363DOI Listing
October 2018
5 Reads

Extracts of different pollen species and their effect on human tear fluid and an epithelial cell line.

Cutan Ocul Toxicol 2019 Mar 13;38(1):93-103. Epub 2018 Nov 13.

a Department of Ophthalmology , Medical University of Graz , Graz , Austria.

Purpose: Hazelnut and birch pollen are known to destroy tear film components and attack ocular surface cells. We investigated further pollen species from different plant families, whether they show similar effects on human tear fluid and an epithelial cell line in vitro, to provide a broad basis for further research on pollen reactions affecting the tear film and ocular surface.

Materials And Methods: Regional pollen species from different plant families (Adoxaceae, Betulaceae, Fagaceae, Juglandaceae, Malvaceae, Oleaceae, Pinaceae, Plantaginaceae, Poaceae, Salicaceae, Sapindaceae) were collected. Read More

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http://dx.doi.org/10.1080/15569527.2018.1530259DOI Listing
March 2019
4 Reads

Allergen-specific immunotherapy.

Allergy Asthma Clin Immunol 2018 12;14(Suppl 2):53. Epub 2018 Sep 12.

3Queen's University, Kingston, ON Canada.

Allergen-specific immunotherapy is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. However, despite its proven efficacy in these conditions, it is frequently underutilized in Canada. The decision to proceed with allergen-specific immunotherapy should be made on a case-by-case basis, taking into account individual patient factors, such as the degree to which symptoms can be reduced by avoidance measures and pharmacological therapy, the amount and type of medication required to control symptoms, the adverse effects of pharmacological treatment, and patient preferences. Read More

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http://dx.doi.org/10.1186/s13223-018-0282-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157282PMC
September 2018
3 Reads

Visual impairment and ocular morbidities among schoolchildren in Southwest, Nigeria.

Niger Postgrad Med J 2018 Jul-Sep;25(3):166-171

Department of Ophthalmology, Guinness Eye Centre, Lagos University Teaching Hospital (LUTH), Lagos, Nigeria.

Aim: The purpose of this study was to determine the prevalence of visual impairment and ocular morbidities among primary and secondary schoolchildren aged 5 years to
Materials And Methods: The study was a population-based descriptive cross-sectional study conducted among schoolchildren aged 5 years to <16 years old attending primary and secondary schools in Ifo, Ifo Local Government Area of Ogun State. Multistage sampling technique was used for the study. Read More

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http://dx.doi.org/10.4103/npmj.npmj_85_18DOI Listing
September 2018
12 Reads

Allergic rhinitis.

Allergy Asthma Clin Immunol 2018 12;14(Suppl 2):51. Epub 2018 Sep 12.

2Division of Allergy and Clinical Immunology, McMaster University, Hamilton, ON Canada.

Allergic rhinitis is a common disorder that is strongly linked to asthma and conjunctivitis. It is usually a long-standing condition that often goes undetected in the primary-care setting. The classic symptoms of the disorder are nasal congestion, nasal itch, rhinorrhea and sneezing. Read More

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http://dx.doi.org/10.1186/s13223-018-0280-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156899PMC
September 2018
3 Reads

An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France.

Allergy Asthma Clin Immunol 2018 24;14:38. Epub 2018 Sep 24.

CHU INSERM U1219, Bordeaux, France.

Background: Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass pollen extract sublingual immunotherapy (5GPE-SLIT) has been developed for the treatment of allergic rhinitis to grass pollen. Read More

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http://dx.doi.org/10.1186/s13223-018-0262-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151918PMC
September 2018
3 Reads

Oral Immunotherapy for Allergic Conjunctivitis Using Transgenic Rice Expressing Hypoallergenic Antigens.

Cornea 2018 Nov;37 Suppl 1:S67-S73

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi, Japan.

Pollinosis, or allergic conjunctivitis and rhinitis induced by pollen, is one of the most common diseases worldwide. In Japan, Japanese cedar (Cryptomeria japonica) pollinosis is a predominant allergic condition that affects more than one-third of all Japanese individuals. Pharmacological treatments of allergic conjunctivitis include administration of antiallergic eye drops containing an antihistamine or mast cell stabilizer. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001758DOI Listing
November 2018
2 Reads

The utility of a normal tear osmolarity test in patients presenting with dry eye disease like symptoms: A prospective analysis.

Cont Lens Anterior Eye 2018 Sep 17. Epub 2018 Sep 17.

Weill Cornell Medicine, Department of Ophthalmology, New York, NY, USA.

Objective: To explore the diagnostic utility of normal tear osmolarity in patients with symptoms suggestive of dry eye disease (DED).

Methods: Prospective observational cohort study of 100 patients that underwent tear osmolarity testing (TearLab) if they endorsed one or more symptoms of potential DED. Patients were included for the study if they had a normal tear osmolarity test (value <308 mOsm/L in each eye, and an inter-eye difference <8 mOsm/L). Read More

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http://dx.doi.org/10.1016/j.clae.2018.09.002DOI Listing
September 2018
9 Reads

Prevalence of ocular morbidity among children aged 17 years or younger in the eastern India.

Clin Ophthalmol 2018 6;12:1645-1652. Epub 2018 Sep 6.

Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar, India,

Purpose: Childhood ocular morbidity involves a spectrum of eye diseases that critically impact the mental development, future education and quality of life. However, there is limited evidence about the early detection and appropriate treatment of ocular morbidity in children <20 years. This study was aimed to assess the prevalence and make a comparison between the different types of ocular morbidity in children of both sexes in the age group of 6-17 years in the eastern India. Read More

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http://dx.doi.org/10.2147/OPTH.S171822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134961PMC
September 2018
8 Reads

Investigation of possible risk factors in the development of seasonal allergic conjunctivitis.

Int J Ophthalmol 2018 18;11(9):1508-1513. Epub 2018 Sep 18.

Department of Ophthalmology, Ardahan State Hospital, Ardahan 75000, Turkey.

Aim: To analyze the possible risk factors in the development of seasonal allergic conjunctivitis (SAC) through an evaluation of skin allergy tests and data obtained from questionnaires.

Methods: The study included a total of 75 SAC patients and 71 control subjects without SAC diagnosis who were admitted to the Abant Izzet Baysal University Medical Faculty Ophthalmology Clinic between March 2016 and December 2016. Skin prick tests were performed for all participants. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.09.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133885PMC
September 2018
11 Reads

Ocular involvement in atopic disease: a review.

Curr Opin Ophthalmol 2018 Nov;29(6):576-581

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami.

Purpose Of Review: To provide a review of the potential sight-threatening sequelae associated with ocular involvement of atopic disease and to discuss the management of this chronic condition.

Recent Findings: There has been a recognition that atopic keratoconjunctivitis (AKC) is a chronic, inflammatory and potentially blinding disease. Recent efforts have focused on steroid sparing, systemic T cell and calcineurin inhibitor medications for the treatment of severe disease. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000532DOI Listing
November 2018
3 Reads

Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis.

J Investig Allergol Clin Immunol 2018 09 17. Epub 2018 Sep 17.

Associate Professor, Pulmonology, Emory University.

Objective: Among the symptom constellation that characterizes allergic conjunctivitis, many such as burning and stinging can be attributed to chronic neuropathic pain. There is accumulating data to support that these hallmark symptoms might be linked to the effects of allergen induced neuromodulation. This review will emphasize the key characteristics of neuropathic itch and pain in allergic conjunctivitis and its pathologic mechanisms. Read More

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http://www.jiaci.org/ahead-of-print/neuropathic-pain-and-itc
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http://dx.doi.org/10.18176/jiaci.0320DOI Listing
September 2018
13 Reads

Urban air pollution and climate change: "The Decalogue: Allergy Safe Tree" for allergic and respiratory diseases care.

Clin Mol Allergy 2018 11;16:20. Epub 2018 Sep 11.

Air Pollution and Climate Change Task Force of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC), Milan, Italy.

Background: According to the World Health Organization, air pollution is closely associated with climate change and, in particular, with global warming. In addition to melting of ice and snow, rising sea level, and flooding of coastal areas, global warming is leading to a tropicalization of temperate marine ecosystems. Moreover, the effects of air pollution on airway and lung diseases are well documented as reported by the World Allergy Organization. Read More

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https://clinicalmolecularallergy.biomedcentral.com/articles/
Publisher Site
http://dx.doi.org/10.1186/s12948-018-0098-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134633PMC
September 2018
6 Reads

Bepotastine besilate for the treatment of perennial allergic rhinitis.

Expert Opin Pharmacother 2018 Oct 12;19(15):1727-1730. Epub 2018 Sep 12.

c Department of Allergy and Clinical Immunology Cleveland Clinic Clinical Associate Professor, FAU Charles E , Schmidt College of Medicine , Weston , FL , USA.

Introduction: Bepotastine besilate (BB) is a second-generation H1-antihistamine that, as an ophthalmic solution, is approved in the United States by the Food and Drug Administration (FDA) for the treatment of allergic conjunctivitis. In other countries, the oral presentation of BB is widely used for the improvement of symptoms of allergic rhinitis (AR) as well as urticaria and chronic pruritus with results similar to those by other drugs of the same class. Areas covered: This article was created from a comprehensive literature search with information taken from clinical trials. Read More

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http://dx.doi.org/10.1080/14656566.2018.1519020DOI Listing
October 2018
3 Reads