25,127 results match your criteria Conjunctivitis


Clinically Relevant Activity of the Novel RASP Inhibitor Reproxalap in Allergic Conjunctivitis: The Phase 3 ALLEVIATE Trial.

Am J Ophthalmol 2021 May 1. Epub 2021 May 1.

Aldeyra Therapeutics, Lexington, MA. Electronic address:

Purpose: To assess the post-acute activity and clinical utility of reproxalap, a novel reactive aldehyde species (RASP) inhibitor, versus vehicle in patients with seasonal allergic conjunctivitis.

Design: Parallel-group, double-masked, randomized Phase 3 trial.

Methods: Two topical ocular reproxalap concentrations (0. Read More

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Single-parenthood and health conditions among children receiving public assistance in Japan: a cohort study.

BMC Pediatr 2021 May 3;21(1):214. Epub 2021 May 3.

Department of Health and Social Behavior, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Children's healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk factor for children owing to low-income-associated food insecurity and stress. Read More

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Novel chitosan-coated niosomal formulation for improved management of bacterial conjunctivitis: A highly permeable and efficient ocular nanocarrier for azithromycin.

J Pharm Sci 2021 Apr 30. Epub 2021 Apr 30.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62111, Egypt.

In the present study, we aimed to formulate, optimize, and characterize azithromycin chitosan coated niosomes (AZM-CTS-NSM) as a novel colloidal system that increases precorneal residence period, eye permeation, and bioavailability. AZM-NSM was formulated via a modified thin-film hydration strategy and then coated with CTS. We assessed the influence of the cholesterol: surfactant molar ratio, CTS concentration, and surfactant type on particle diameter, entrapment, zeta potential, and NSM adhesion force to the corneal mucosal membrane and employed a central composite design (CCD). Read More

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Corneal biomechanical changes in allergic conjunctivitis.

Eye Vis (Lond) 2021 May 3;8(1):17. Epub 2021 May 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Background: To explore corneal biomechanical changes, identify related factors and determine early indicators of keratoconus (KC) development risk in allergic conjunctivitis (AC) patients.

Methods: A total of 50 patients, including 20 eyes without AC and 30 eyes with AC were enrolled in this study. All patients underwent a complete ocular examination, including evaluations of clinical manifestations of AC, corneal tomography and densitometry by Pentacam, corneal biomechanics by Corvis ST, and corneal and epithelial thickness mapping by RTvue optical coherence tomography (OCT). Read More

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Isolation of Moraxella spp. from horses with conjunctivitis in Southern Brazil.

Braz J Microbiol 2021 Apr 30. Epub 2021 Apr 30.

Departamento de Medicina Veterinária Preventiva (DMVP), Centro de Ciências Rurais (CCR), UFSM, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.

Infectious keratoconjunctivitis (IKC) is the most frequent ocular disease in livestock worldwide and is primarily caused by Moraxella bovis, M. ovis, and/or M. bovoculi. Read More

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Visual Diagnosis: High Fever, Maculopapular Rash, Perianal Desquamation, and Conjunctivitis in a 3-year-old Boy.

Pediatr Rev 2021 May;42(5):e17-e22

Division of Cardiology, Department of Pediatrics, University of Southern California, Los Angeles, CA.

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Testing for and identification of Multisystem Inflammatory Syndrome in children in the pediatric emergency department.

Curr Opin Pediatr 2021 06;33(3):275-280

Cohen Children's Medical Center, New Hyde Park, New York, USA.

Purpose Of Review: The current article summarizes updates on multisystem inflammatory syndrome in children (MIS-C) research and focuses on strategies to diagnose and manage these patients in the emergency department.

Recent Findings: MIS-C is an inflammatory syndrome that occurs approximately 4-5 weeks after severe acute respiratory syndrome coronavirus 2 infection. It is associated with symptoms such as fever, shock, abdominal pain, rash, and conjunctivitis along with laboratory abnormalities such as elevated inflammatory markers, coagulation factors, and cytokines. Read More

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The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies.

Cells 2021 04 2;10(4). Epub 2021 Apr 2.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 6020841, Japan.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem. Although the respiratory system is the main impaired organ, conjunctivitis is one of its common findings. However, it is not yet understood if SARS-CoV-2 can infect the eye and if the ocular surface can be a potential route of SARS-CoV-2 transmissions. Read More

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Molecularsensitization patterns in animal allergy: relationship with clinical relevance and pet ownership.

Allergy 2021 Apr 29. Epub 2021 Apr 29.

Floridsdorf Allergy Center (FAZ), Vienna, Austria.

Background: In-vitro diagnosis using single molecules is increasingly complementing conventional extract-based diagnosis.We explored in routine patients with animal allergy to what extent molecules can explain polysensitization and identify primary sensitizers and how individual IgE patterns correlate with previous pet ownership and clinical relevance.

Methods: Serum samples from 294 children and adults with suspect allergic rhino-conjunctivitis or asthma anda positive skin prick test to cat, dog and/or horse were tested by ImmunoCAP for IgE antibodies against eleven different allergens from cat (Fel d 1,2,4,7), dog (Can f 1,2,3,4,5,6) and horse (Equ c 1). Read More

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Reactive Arthritis following Bacillus Calmette-Guerin Therapy for Bladder Cancer: a Systematic Literature Review.

Curr Rheumatol Rep 2021 Apr 28;23(6):39. Epub 2021 Apr 28.

Rheumatology Department, Mongi Slim Hospital, La Marsa, Tunisia.

Purpose Of Review: Intravesical BCG therapy (ivBCG) is a treatment for bladder cancer that complements surgery and prevents tumor progression. Reactive arthritis (ReA) is a rare osteoarticular manifestation that can complicate this treatment. An updated systematic literature review has been investigated to identify clinical, biological, and therapeutic data of this pathology. Read More

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Application of adverse outcome pathway networks to integrate mechanistic data informing the choice of a point of departure for hydrogen sulfide exposure limits.

Crit Rev Toxicol 2021 Apr 27:1-16. Epub 2021 Apr 27.

ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, USA.

Acute exposure to hydrogen sulfide initiates a series of hallmark biological effects that occur progressively at increasing exposure levels: odor perception, conjunctivitis, olfactory paralysis, "knockdown," pulmonary edema, and apnea. Although effects of exposure to high concentrations of hydrogen sulfide are clear, effects associated with chronic, low-level exposure in humans is under debate, leading to uncertainty in the critical effect used in regulatory risk assessments addressing low dose exposures. This study integrates experimental animal, observational epidemiology, and occupational exposure evidence by applying a pathway-based approach. Read More

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Imaging findings of multisystem inflammatory syndrome in children associated with COVID-19.

Pediatr Radiol 2021 Apr 27. Epub 2021 Apr 27.

Diagnostic Imaging, University Children's Hospital Zurich, Zurich, Switzerland.

Background: A hyperinflammatory immune-mediated shock syndrome has been recognised in children exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19).

Objective: To describe typical imaging findings in children with multisystem inflammatory syndrome associated with COVID-19.

Materials And Methods: During the first wave of the COVID-19 pandemic, imaging studies and clinical data from children treated for multisystem inflammatory syndrome were collected from multiple centres. Read More

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A case of multisystem inflammatory syndrome in children in a japanese boy: with discussion of cytokine profile.

Mod Rheumatol Case Rep 2021 Apr 27:1-11. Epub 2021 Apr 27.

Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

The new disease concept of multisystem inflammatory syndrome in children (MIS-C), which is a systemic inflammatory syndrome with multiple organ involvement after SARS-CoV2 infection, was established in 2020. MIS-C is common in Hispanic and black children in Europe and North America, with few reports in East Asians. A significant portion of patients with MIS-C develop Kawasaki disease (KD)-like symptoms. Read More

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Combinations of self-reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes.

Clin Transl Allergy 2021 Mar;11(1):e12013

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.

Background: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed.

Objectives: The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors.

Methods: From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Read More

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Effectiveness of Chlamydia Trachomatis expedited partner therapy in pregnancy.

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center Dallas, Texas; Department of Obstetrics and Gynecology, Parkland Health and Hospital Systems, Dallas, Texas.

Background: Expedited partner therapy for chlamydia trachomatis has had mixed efficacy in different populations, but data are lacking on the efficacy in a pregnant population.

Objectives: Evaluate the real-world effectiveness of establishing a prenatal expedited partner therapy program in eradicating chlamydia before delivery. To examine the maternal and neonatal outcomes among women treated for chlamydia in pregnancy compared among those that received expedited partner therapy to those that underwent standard partner-referral testing and treatment. Read More

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Effectiveness of Chlamydia Trachomatis expedited partner therapy in pregnancy.

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center Dallas, Texas; Department of Obstetrics and Gynecology, Parkland Health and Hospital Systems, Dallas, Texas.

Background: Expedited partner therapy for chlamydia trachomatis has had mixed efficacy in different populations, but data are lacking on the efficacy in a pregnant population.

Objectives: Evaluate the real-world effectiveness of establishing a prenatal expedited partner therapy program in eradicating chlamydia before delivery. To examine the maternal and neonatal outcomes among women treated for chlamydia in pregnancy compared among those that received expedited partner therapy to those that underwent standard partner-referral testing and treatment. Read More

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Detection of SARS-CoV-2 in respiratory samples from cats in the UK associated with human-to-cat transmission.

Vet Rec 2021 04 22;188(8):e247. Epub 2021 Apr 22.

Veterinary Diagnostics Service, School of Veterinary Medicine, University of Glasgow, Glasgow, UK.

Objectives: The aim of the study was to find evidence of SARS-CoV-2 infection in UK cats.

Design: Tissue samples were tested for SARS-CoV-2 antigen using immunofluorescence and for viral RNA by in situ hybridisation. A set of 387 oropharyngeal swabs that had been submitted for routine respiratory pathogen testing was tested for SARS-CoV-2 RNA using reverse transcriptase quantitative PCR. Read More

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A novel case of ocular cicatricial pemphigoid induced by levamisole-adulterated cocaine.

Eur J Ophthalmol 2021 Apr;31(1_suppl):11-15

Department of Ophthalmology, King's College Hospital, London, UK.

Aim: To report a case of ocular cicatricial pemphigoid caused by levamisole-adulterated cocaine.

Methods: Case report.

Results: A 54-year-old woman with multi-systemic levamisole-induced vasculitis which triggered bilateral cicatrizing conjunctivitis refractory to conventional immunosuppressants due to continued cocaine misuse. Read More

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Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platforms.

Clin Exp Allergy 2021 Apr 20. Epub 2021 Apr 20.

Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany.

Background: The practice of allergology varies widely between countries, and the costs and sales for the treatment of rhinitis differ depending on practices and health systems. To understand these differences and their implications, the rhinitis market was studied in some of the EU countries.

Methods: We conducted a pharmaco-epidemiological database analysis to assess the medications that were prescribed for allergic rhinitis in the years 2016, 2017 and 2018. Read More

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Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study.

Clin Ophthalmol 2021 13;15:1551-1556. Epub 2021 Apr 13.

Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA.

Purpose: Studies have identified a wide range of ocular signs and symptoms in coronavirus disease 2019 (COVID-19) patients; however, these studies were often conducted outside of the United States. We aim to investigate the ocular manifestations of hospitalized COVID-19 patients at a tertiary care medical center in the United States.

Patients And Methods: A retrospective, cross-sectional study was conducted on individuals aged 18 and over who were hospitalized for COVID-19 between March 10, 2020 and April 13, 2020. Read More

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An unusual and atypical presentation of the novel coronavirus: A case report and brief review of the literature.

J Taibah Univ Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Radiology, Faculty of Medicine, Taibah University, Almadinah Almunawwarah, KSA.

The coronavirus disease 2019 (COVID-19) is a highly contagious novel infection that predominantly presents with fever and respiratory symptoms. However, COVID-19 can masquerade as an acute coronary syndrome, leg pain or swelling with venous thrombosis, loss of consciousness with cerebral venous thrombosis, confusion, limb weakness with brain infarction, facial neuralgia, acute conjunctivitis, acute appendicitis, and testicular pain. We report on a 42-year-old man who presented with mild symptoms of COVID-19. Read More

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Utilization trends of an ophthalmology-specific emergency department: the Massachusetts Eye and Ear experience.

Digit J Ophthalmol 2021 Feb 12;26(4):31-35. Epub 2020 Oct 12.

Department of Ophthalmology, Massachusetts Eye and Eye Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To describe the utilization trends of a dedicated ophthalmology emergency department (ED) in Boston, Massachusetts.

Methods: The medical records of 500 randomly selected patients who presented at the Massachusetts Eye and Ear (MEE) Emergency Department (ED) from January 2015 to March 2016 were reviewed retrospectively. Data were analyzed using the Pearson χ2 test and multiple logistic regression. Read More

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February 2021

Keratoconus in Africa: A systematic review and meta-analysis.

Ophthalmic Physiol Opt 2021 Apr 16. Epub 2021 Apr 16.

Department of Optometry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Purpose: The aim of this review is to evaluate the prevalence of and factors associated with keratoconus in Africa.

Method: A systematic online literature search was conducted for articles on keratoconus in Africa. Meta-analysis was performed to estimate the prevalence of keratoconus in Africa. Read More

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Infection of bronchial epithelial cells by the human adenoviruses A12, B3 and C2 differently regulates the innate antiviral effector APOBEC3B.

J Virol 2021 Apr 14. Epub 2021 Apr 14.

Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit (URVI), University of Namur, Namur, Belgium

Human adenoviruses (HAdVs) are a large family of DNA viruses counting more than 100 genotypes divided into seven species (A-G) and inducing respiratory tract infections, gastroenteritis and conjunctivitis. Genetically modified adenoviruses are also used as vaccines, gene therapies and anti-cancer treatments. The APOBEC3s are a family of cytidine deaminases that restrict viruses by introducing mutations in their genomes. Read More

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Prevalence of trachoma in Pernambuco State, Brazil (2014-2015).

Rev Inst Med Trop Sao Paulo 2021 12;63:e29. Epub 2021 Apr 12.

Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Recife, Pernambuco, Brazil.

To estimate the prevalence of cases of trachoma in the population at social risk aged 1-9 years in Pernambuco State and its mesoregions. This was a cross-sectional study in which secondary data from the National Household Survey on Trachoma (2014-2015) were analyzed. The study covered 96 census tracts distributed across the mesoregions of Pernambuco State (Metropolitan Region of Recife, Zona da Mata, Agreste, Sertao do Sao Francisco and Sertao Pernambucano). Read More

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Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study.

PLoS One 2021 14;16(4):e0249649. Epub 2021 Apr 14.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Allergic rhino-conjunctivitis with pollen allergy has been prevalent worldwide and Pollen-food allergy syndrome (PFAS) refers to individuals with pollen allergy who develop oral allergy syndrome (OAS) on consuming fruits and vegetables. The prevalence of PFAS varies by region and that in Japanese adolescents remains to be elucidated. In this cross-sectional study, we examined the epidemiological characteristics of PFAS in a general population of Japanese adolescents according to pollen allergy, OAS, and IgE component sensitization. Read More

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Involvement of Laryngopharyngeal Reflux in Ocular Diseases: A State-of-the-Art Review.

J Voice 2021 Apr 10. Epub 2021 Apr 10.

Anatomy and Cell Biology Department, Faculty of Medicine, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000, Mons, Belgium; Pediatrics Department. Complexo Hospitalario Universitario A Coruña (CHUAC), 15006, A Coruña, Galicia, Spain.

Background: Laryngopharyngeal reflux-associated symptoms embrace a wide variety of head and neck manifestations. Its participation in eye disorders has recently been postulated, and there is currently no consensus in this regard. The aim of this manuscript is to review the role of reflux in the development of ocular signs and symptoms, and its physio-pathological mechanisms. Read More

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Prevalence and molecular characterization of C. pecorum detected in Swiss fattening pigs.

Vet Microbiol 2021 May 31;256:109062. Epub 2021 Mar 31.

Institute of Veterinary Pathology, Vetsuisse-Faculty University Zurich, Zurich, 8057, Switzerland; Center for Clinical Studies, Vetsuisse-Faculty, University of Zurich, Zurich, 8057, Switzerland.

Chlamydia (C.) pecorum, an obligate intracellular bacterial species commonly found in ruminants, can also occur in pigs. However, its significance as a potential porcine pathogen, or commensal, is still unclear. Read More

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Differences Between Pediatric Acute Myocarditis Related and Unrelated to SARS-CoV-2.

Pediatr Infect Dis J 2021 05;40(5):e173-e178

School of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Acute myocarditis (AM) is defined as inflammation of the myocardium. The aim of our study is a comparative analysis of the differences between AM related and unrelated to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: The retrospective study included children with AM treated from January 2018 to November 2020. Read More

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