23,357 results match your criteria Conjunctivitis


Effects of three husbandry systems on health, welfare and productivity of organic pigs.

Animal 2019 Feb 14:1-9. Epub 2019 Feb 14.

10Institute of Animal Welfare and Animal Husbandry,Friedrich-Loeffler-Institute,Dörnbergstraße 25/27,29223 Celle,Germany.

Organic pig husbandry systems in Europe are diverse - ranging from indoor systems with concrete outside run (IN) to outdoor systems all year round (OUT) and combinations of both on one farm (POUT). As this diversity has rarely been taken into account in research projects on organic pig production, the aim of this study was to assess and compare pig health, welfare and productivity in these three systems. Animal health and welfare were assessed using direct observation and records of 22 animal-based measures, comprising 17 health-, 3 productivity- and 2 behavioural measures. Read More

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http://dx.doi.org/10.1017/S1751731119000041DOI Listing
February 2019

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
2 Reads

Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
1 Read

Immunohistochemical evaluation of natural cases of encephalitic listeriosis in sheep.

Biotech Histochem 2019 Feb 7:1-7. Epub 2019 Feb 7.

b Faculty of Veterinary Medicine, Department of Pathology , University of Mehmet Akif Ersoy , Burdur , Turkey.

Listeriosis is an important public health problem in the world. It can cause abortion, encephalitis, septicemia, conjunctivitis and mastitis in ruminants. The development of central nervous system lesions is not fully understood in encephalitic listeriosis. Read More

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http://dx.doi.org/10.1080/10520295.2019.1571225DOI Listing
February 2019

Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018.

Arch Virol 2019 Feb 6. Epub 2019 Feb 6.

Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

A large outbreak (over 200,000 cases) of acute hemorrhagic conjunctivitis (AHC) took place in Brazil during the summer of 2017/2018, seven years after a nationwide epidemic, which occurred in 2011. To identify the etiological agent, 80 conjunctival swabs from patients with a clinical presentation suggestive of AHC were analyzed at the national enterovirus laboratory. Real-time RT-PCR for human enteroviruses was performed, and enterovirus RNA was detected in 91. Read More

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http://dx.doi.org/10.1007/s00705-019-04157-5DOI Listing
February 2019

Chronic Conjunctivitis From a Retained Contact Lens.

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Sciences (J.I.A., A.S., and R.R.S.), Case Western Reserve University and University Hospitals Eye Institute, Cleveland, OH; Skyvision Centers (D.E.W.), Westlake, OH; and Division of Cornea and Refractive Surgery (N.A.A.), Shiley Eye Institute, University of California San Diego, San Diego, CA.

Purpose: To help clinicians diagnose and manage unilateral recalcitrant chronic bacterial conjunctivitis secondary to a retained soft contact lens and describe the first report of Gram-negative bacteria causing this condition.

Methods: Chart review of successive cases presenting with unilateral chronic conjunctivitis with positive cultures and a retained contact lens.

Results: Three cases were identified and described. Read More

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http://Insights.ovid.com/crossref?an=00140068-900000000-9917
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http://dx.doi.org/10.1097/ICL.0000000000000587DOI Listing
February 2019
3 Reads

Development of conjunctivitis with a conjunctival proliferative lesion in a patient treated with dupilumab for atopic dermatitis.

Allergol Int 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kochi, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.12.012DOI Listing
February 2019

Letter regarding "Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab-clinical characteristics and treatment".

J Allergy Clin Immunol Pract 2019 Feb;7(2):753

Department of Allergy, Hospital Universitario Fundación Jimenez Diaz, Instituto de Investigación Sanitaria Fundación Jimenez Diaz (IIS-FJD, UAM), Madrid, Spain; CIBER de enfermedades respiratorias (CIBERES), Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.1016/j.jaip.2018.10.055DOI Listing
February 2019

Omalizumab for atopic dermatitis: evidence for and against its use.

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Introduction: Omalizumab, has been used for almost two decades, mainly in allergic asthma and chronic spontaneous urticaria for which it is highly beneficial. Smaller studies have evaluated the effects of omalizumab in atopic dermatitis (AD). Current treatments options, such as cyclosporine and azathioprine have limited effect on AD and numerous side effects. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06302-8DOI Listing
February 2019
1 Read

Utility of Pediatric Allergic Disease Quality of Life Questionnaire for childhood eczema.

Br J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Paediatrics, Kwong Wah Hospital, Hong Kong.

Aim: It is important to objectively evaluate quality of life (QoL) impairment in atopic diseases in children. This study aims to investigate the utility of a Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) in children with eczema.

Methods: PADQLQ, Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score) were compared and correlations evaluated. Read More

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http://doi.wiley.com/10.1111/bjd.17710
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http://dx.doi.org/10.1111/bjd.17710DOI Listing
February 2019
5 Reads

Eye diseases: the neglected health condition among urban slum population of Dhaka, Bangladesh.

BMC Ophthalmol 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

BRAC James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.

Introduction: Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21. Read More

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http://dx.doi.org/10.1186/s12886-019-1043-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357461PMC
January 2019
1 Read
1.075 Impact Factor

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care.

Clin Microbiol Infect 2019 Jan 28. Epub 2019 Jan 28.

Sorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé publique (IPLESP UMRS 1136), Paris, France; Université de Versailles Saint-Quentin-en-Yvelines, UVSQ, UFR de Médecine, Versailles, France; Assistance Publique - Hôpitaux de Paris APHP, Hôpital Ambroise Paré, Service de Médecine Interne, Boulogne Billancourt, France.

Objectives: We aimed to identify patients' clinical characteristics associated with respiratory viruses identified among patients presenting with influenza-like illness (ILI).

Methods: A sample of patients of all ages presenting with ILI was included by physicians of the French Sentinelles network during two seasons (2015/16 and 2016/17). Nasopharyngeal samples were tested for the presence of influenza virus (IV), respiratory syncytial virus (RSV), rhinovirus (HRV), and metapneumovirus (HMPV). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.014DOI Listing
January 2019
1 Read

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Int Arch Allergy Immunol 2019 Jan 30:1-10. Epub 2019 Jan 30.

Department of Respiratory Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.

Objective: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models. Read More

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http://dx.doi.org/10.1159/000494932DOI Listing
January 2019
1 Read

In vitro and in vivo performance of epinastine hydrochloride-releasing contact lenses.

PLoS One 2019 30;14(1):e0210362. Epub 2019 Jan 30.

Department of Ophthalmology, Nihon University, Itabashi, Tokyo, Japan.

A number of drug-releasing contact lenses are currently being studied to address issues inherent in eye drops as a drug delivery method. In this study, we developed epinastine hydrochloride-releasing daily soft contact lenses for treatment of allergic conjunctivitis and examined their in vitro and in vivo performance. Preformed soft contact lenses with/without ionic functional groups were soaked in a solution of epinastine hydrochloride in phosphate-buffered saline to prepare epinastine hydrochloride-releasing soft contact lenses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353132PMC
January 2019
2 Reads

Assessment of trachoma in suspected endemic areas within 16 provinces in mainland China.

PLoS Negl Trop Dis 2019 Jan 28;13(1):e0007130. Epub 2019 Jan 28.

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing, China.

Background: China used to be among the countries with a high prevalence of trachoma. At the launch of The Global Elimination of Trachoma (GET) 2020 campaign by the World Health Organization (WHO) in 1996, China was placed on the list of countries endemic for trachoma based on historical data. However, empirical observation and routinely collected eye care data were suggesting that trachoma was no longer a public health problem. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007130DOI Listing
January 2019
1 Read

A Review on Blighia Sapida K.D. Koenig (syn. Cupania sapida Voigt.)'s: Its Economic Importance, Phytochemistry and Pharmacological Activity: Channeling these Claims for the Present and Future.

J Ethnopharmacol 2019 Jan 24. Epub 2019 Jan 24.

Dept. of Applied Chemistry, Federal University Dutsin-Ma, Katsina State, Nigeria; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Ethnopharmacological Relevance: Ackee plant (Blighia sapida K. D. Koenig) (Sapindaceae) is used in Sub-Saharan African where it has its origin and in different parts of the world (The Caribbean, North and South America, Europe) traditionally to manage numerous ailments like backache, constipation, cancer, fever in young children, gonorrhea, dysentery, psychosis, hernia, stomach ache, malaria, rheumatism, typhoid and several others. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.017DOI Listing
January 2019
6 Reads

Contact dermatitis to polyacrylamide/C13-4 isoparaffin/laureth-7 mix in an emollient cream for atopic skin.

Contact Dermatitis 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology, University of Montpellier, France.

A 33-year-old female with a history of atopic dermatitis and seasonal rhino-conjunctivitis was referred to investigate eczema. The atopic dermatitis had been active since infancy, then ceased during her teenage years but relapsed starting with the age of 25, mainly on the hands. She reported a recent flare up of inflammatory skin lesions on her chest, arms and face after applying a moisturizing cream to attenuate atopic skin-related dryness on these areas. Read More

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http://dx.doi.org/10.1111/cod.13234DOI Listing
January 2019
3 Reads

Allergy screening in a schoolchildren-based population.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Background: Schoolchildren screening for allergic diseases may improve early identification and management of atopic children. The aim of this study was to perform a schoolchildren screening program for identification of children with allergic diseases.

Methods: All parents of children attending to 13 primary schools in the city of Rome were requested to fill in a demographic data form and the ChAt questionnaire. Read More

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http://dx.doi.org/10.1111/pai.13024DOI Listing
January 2019
1 Read

Epidemiological characteristics, clinical manifestations, and treatment outcome of 139 paediatric Ebola patients treated at a Sierra Leone Ebola treatment center.

BMC Infect Dis 2019 Jan 24;19(1):81. Epub 2019 Jan 24.

Center for International Health, University of Munich (LMU), Munich, Germany.

Background: The West Africa Ebola Virus Disease (EVD) outbreak in 2014-2016 was declared by the World Health Organization (WHO) a public health emergency of international concern. Most of the previous studies done in Sierra Leone relating to the clinical and epidemiological features of EVD during the 2014-2016 West African outbreak focused on adult EVD patients. There have been conflicting reports about the effects of EVD on children during previous outbreaks. Read More

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http://dx.doi.org/10.1186/s12879-019-3727-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344993PMC
January 2019

Lassa Fever in Travelers from West Africa, 1969-2016.

Emerg Infect Dis 2019 Feb;25(2):245-248

Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non-Lassa-endemic countries from West Africa. We describe a retrospective review performed through literature search of clinical and epidemiologic characteristics of all imported Lassa fever cases worldwide during 1969-2016. Our findings demonstrate that approximately half of imported cases had distinctive clinical features (defined as fever and >1 of the following: pharyngitis, sore throat, tonsillitis, conjunctivitis, oropharyngeal ulcers, or proteinuria). Read More

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http://dx.doi.org/10.3201/eid2502.180836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346466PMC
February 2019
1 Read

Evaluation of a silver-amplified immunochromatography kit for adenoviral conjunctivitis.

J Med Virol 2019 Jan 19. Epub 2019 Jan 19.

Department of Ophthalmology, Fukushima Medical University School of Medicine, Hobara Eye Clinic, Date, Japan.

Objective: To compare and evaluate the sensitivity of a newly developed silver-amplified immunochromatography (SAI) kit with various immunochromatography (IC) kits for adenoviruses based on the detection limit (copies/test).

Methods: An SAI kit and four ophthalmic IC kits were evaluated. The detection limits of the five kits were determined using the limiting dilution method for 15 conjunctivitis-associated adenoviruses (adenoviruses 1, 2, 3, 4, 5, 7, 8, 11, 37, 53, 54, 56, 64, 81, and 85). Read More

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http://doi.wiley.com/10.1002/jmv.25404
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http://dx.doi.org/10.1002/jmv.25404DOI Listing
January 2019
3 Reads

Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon.

PLoS Pathog 2019 Jan 18;15(1):e1007507. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America.

Zika virus (ZIKV) infection during pregnancy in humans is associated with an increased incidence of congenital anomalies including microcephaly as well as fetal death and miscarriage and collectively has been referred to as Congenital Zika Syndrome (CZS). Animal models for ZIKV infection in pregnancy have been developed including mice and non-human primates (NHPs). In macaques, fetal CZS outcomes from maternal ZIKV infection range from none to significant. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355048PMC
January 2019
2 Reads

Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis.

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden.

Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. Read More

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http://dx.doi.org/10.2340/00015555-3121DOI Listing
January 2019
2 Reads

Asymptomatic Follicular Conjunctivitis in an Elderly Man.

JAMA Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Cornea and External Disease, Louis Stokes Cleveland Veteran Affairs Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.5464DOI Listing
January 2019

Hyperacute Gonococcal Keratoconjunctivitis.

J Gen Intern Med 2019 Jan 16. Epub 2019 Jan 16.

Department of Emergency Medicine, University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1007/s11606-018-4825-8DOI Listing
January 2019

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children.

Ital J Pediatr 2019 Jan 15;45(1):16. Epub 2019 Jan 15.

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0603-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334451PMC
January 2019
3 Reads

Crohns disease of the appendix - a case report.

Rozhl Chir 2018 ;97(12):563-567

Introduction: Crohns disease is a chronic inflammatory autoimmune disease with unknown etiology. Although the disease may involve any part of the gastrointestinal tract, the most frequently affected site is the terminal ileum. Crohns disease itself is more common in women and in younger patients. Read More

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January 2018
4 Reads

Prevention of canine ocular thelaziosis (Thelazia callipaeda) with a combination of milbemycin oxime and afoxolaner (Nexgard Spectra) in endemic areas in France and Spain.

Parasite 2019 15;26. Epub 2019 Jan 15.

Boehringer Ingelheim Animal Health, 29 avenue Tony Garnier, 69007 Lyon, France.

In the past decade, canine thelaziosis due to Thelazia callipaeda has been diagnosed in an increasing number of European countries, with endemic areas being identified. A multi-center field trial was conducted in endemic areas in France and Spain to evaluate the efficacy of monthly administrations of the oral milbemycin oxime/afoxolaner combination (NexGard Spectra) for the prevention of T. callipaeda infection in at-risk dogs. Read More

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http://dx.doi.org/10.1051/parasite/2019001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333103PMC
January 2019
1 Read

Corneal Cross-Linking Window Absorption (CXL-WA) as an Adjuvant Therapy in the Management of Keratitis.

Case Rep Ophthalmol Med 2018 10;2018:4856019. Epub 2018 Dec 10.

Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milano, Italy.

Purpose: To evaluate the effectiveness of corneal cross-linking window absorption (CXL-WA) as an adjuvant therapy for keratitis.

Methods: A 90-year-old male came to our clinic complaining of hyperemic conjunctivitis and progressive visual loss in the right eye. Slit-lamp examination showed keratic precipitates, severe corneal opacity, and stromal edema. Read More

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https://www.hindawi.com/journals/criopm/2018/4856019/
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http://dx.doi.org/10.1155/2018/4856019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311300PMC
December 2018
5 Reads

Effectiveness of the spot-on combination of moxidectin and imidacloprid (Advocate®) in the treatment of ocular thelaziosis by Thelazia callipaeda in naturally infected cats.

Parasit Vectors 2019 Jan 11;12(1):25. Epub 2019 Jan 11.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010, Valenzano, Italy.

Background: The present study evaluated the therapeutic effectiveness of moxidectin 1.0% (w/v) and imidacloprid 10% (w/v) (Advocate® spot-on solution for cats, Bayer Animal Health) against natural infections with the eyeworm Thelazia callipaeda in cats. This study was conducted as a GCP, negative-controlled, blinded and randomised field study in privately owned cats living in an area in southern Italy where T. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3262-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329153PMC
January 2019
4 Reads

Dark skin phototype is associated with more severe ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology - Charles Nicolle University Hospital, Rouen, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe skin reactions with extensive apoptosis of the epidermis and mucous membranes. Ocular involvement occurs in up to 75% of patients at the acute phase, described as mild, moderate and severe involvement and may result in long-term severe sequelae with dryness, photophobia, cicatrising conjunctivitis complicated with corneal vascularisation and scarring, which may result in severe visual loss. The acute management of SJS/TEN ocular complications has not been codified. Read More

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http://dx.doi.org/10.1111/bjd.17627DOI Listing
January 2019
7 Reads

Preparation and Evaluation of N-Trimethyl Chitosan Nanoparticles of Flurbiprofen for Ocular Delivery.

Curr Eye Res 2019 Jan 11:1-8. Epub 2019 Jan 11.

b SPP School of Pharmacy and Technology Management , NMIMS University , Mumbai , India.

Purpose: A major challenge in ocular therapeutics is poor bioavailability of drug, 1% or even less of the instilled dose is absorbed and frequent administration of conventional products leads to poor adherence to therapy. Hence, the present study is to synthesize N-trimethyl chitosan (TMC), a water-soluble chitosan derivative and to prepare flurbiprofen (FLU):hydroxyl propyl-β-cyclodextrin (HP-β-CD) complex-loaded nanoparticles for treatment of bacterial conjunctivitis which aims to increase the residence time in ocular tissue, thus enhancing patient compliance and improved efficacy.

Methods: TMC was synthesized and characterized by H NMR and FT-IR. Read More

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http://dx.doi.org/10.1080/02713683.2019.1567793DOI Listing
January 2019
1 Read

Biological occupational allergy: Protein microarray for the study of laboratory animal allergy (LAA).

AIMS Public Health 2018 9;5(4):352-365. Epub 2018 Oct 9.

Associated Centers for Molecular Allergology, Rome, Italy; Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.

Background: Laboratory Animal Allergy (LAA) has been considered a risk for the workers since 1989 by the NIOSH. About one third of the Laboratory Animal Workers (LAWs) can manifest symptoms to LAA as asthma, rhinitis, conjunctivitis and cutaneous reactions. The prevalence of LAA-induced clinical symptoms has been estimated with a great variability (4-44%) also due to the different methodologies applied. Read More

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http://dx.doi.org/10.3934/publichealth.2018.4.352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322995PMC
October 2018
1 Read

Two differing presentations of periocular dermatitis as a side effect of dupilumab for atopic dermatitis.

Orbit 2019 Jan 10:1-5. Epub 2019 Jan 10.

c Edward S. Harkness Eye Institute , Columbia University Irving Medical Center , New York , NY , USA.

Dupilumab is a monoclonal antibody used to treat atopic dermatitis. Worsening of atopic dermatitis and conjunctivitis following dupilumab use are reported adverse effects; however, there is little reported on the nature and mechanism of these complications. Here, we describe two patients with chronic atopic dermatitis who developed new or severely worsened periocular dermatitis, believed to be a side effect of dupilumab injections, and resolution after its discontinuation. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2018.1
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http://dx.doi.org/10.1080/01676830.2018.1553190DOI Listing
January 2019
4 Reads

Ophthalmia Neonatorum.

Authors:
Aik-Kah Tan

N Engl J Med 2019 Jan;380(2):e2

Normah Medical Specialist Center, Kuching, Malaysia

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http://dx.doi.org/10.1056/NEJMicm1808613DOI Listing
January 2019

Evaluation of the placebo effect in the trials of allergen immunotherapy effectiveness: meta-analysis of randomized and placebo-controlled trials.

Postepy Dermatol Alergol 2018 Dec 13;35(6):620-625. Epub 2018 Nov 13.

Department of Infectious Diseases and Allergology, Military Institute of Medicine, Warsaw, Poland.

Introduction: The total effect of the method of treatment is composed of its specific activity depending on its impact on the disease mechanism and the non-specific activity, i.e. the placebo effect. Read More

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http://dx.doi.org/10.5114/ada.2018.77614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320494PMC
December 2018
1 Read

Human adenoviral type 54 keratoconjunctivitis accompanied by stellate keratitis and keratic precipitates: two cases.

BMC Ophthalmol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Ophthalmology, Faculty of Medicine, Tottori University, 36-1 Nishicho Yonago City, Tottori, Japan.

Background: Of the 10 patients with adenoviral type 54 keratoconjunctivitis examined at Nojima Hospital, 2 developed stellate keratitis and mutton-fat keratic precipitates (KPs) following acute symptoms.

Case Presentation: We encountered 10 cases of epidemic keratoconjunctivitis from August to October 2017. All patients were adults with a mean age of 60. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1025-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323660PMC
January 2019
7 Reads

[Ocular dermoids and microphthalmia in a juvenile sheep].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2018 Dec 7;46(6):379-384. Epub 2019 Jan 7.

A 6-month-old Leine sheep was presented because of dermal tissue located on the left eye. During the first examination, the animal was clinically silent, apart from the deformed eye. A corneal and conjunctival dermoid and blindness of the left eye were diagnosed. Read More

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http://dx.doi.org/10.15653/TPG-170690DOI Listing
December 2018

Current pharmaceutical developments in atopic dermatitis.

Curr Opin Pharmacol 2019 Jan 2;46:7-13. Epub 2019 Jan 2.

Aarhus University Hospital, Department of Dermatology, Aarhus, Denmark.

Atopic dermatitis (AD) is an inflammatory, pruritic, chronic or chronically relapsing skin disease that typically begins in early childhood and is occurring frequently in families with other atopic diseases (bronchial asthma and/or allergic rhino-conjunctivitis). Thanks to immunological and neurobiological research, the era of new treatments is coming as well as it occurred with psoriasis 15 years ago. Many treatments targeting cytokines (IL-4, IL-13, IL-31, TSLP) or neurotransmitters (substance P, opioids) or their respective receptors as well as phosphodiesterase-4 or the Jak/Stat pathways are under development. Read More

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http://dx.doi.org/10.1016/j.coph.2018.12.003DOI Listing
January 2019
3 Reads

Evaluation of Patients for Zika Virus Infection in a Travel Clinic in the Southeast United States, 2016.

South Med J 2019 Jan;112(1):45-51

From the Department of Family and Preventive Medicine and the Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, the Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, and the School of Public Health, State University of New York, Albany.

Objectives: Zika virus is an emerging infection that has posed vexing challenges to the US public health system. Improved characterization of patients with possible and confirmed infection is needed to better understand risks for infection in US travelers and to inform evolving evaluation guidelines.

Methods: We performed a retrospective electronic health record review of patients evaluated for Zika virus infection at an academic travel clinic in Atlanta, Georgia, from January 1 through August 31, 2016. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000917DOI Listing
January 2019
1 Read

[Reasons for the development of allergies in children].

HNO 2019 Feb;67(2):90-97

Klinik für Hals-Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.

Allergies are one of the most common chronic diseases in childhood, contributing to a tremendous medical and economical burden in health care systems of most industrialized countries. The development of allergies is dependent on a complex interaction of-among others-environmental factors, nutrition, genetic and epigenetic mechanisms as well as the microbiome. These diverse factors can influence early life immune regulation including innate and adaptive immune mechanisms in a complex fashion. Read More

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http://dx.doi.org/10.1007/s00106-018-0595-1DOI Listing
February 2019
6 Reads

[Prevalence of asthma, allergic rhinitis and atopic dermatitis in school children of the Mexican Bajío region].

Rev Alerg Mex 2018 Oct-Dec;65(4):372-378

Universidad Quetzalcóatl en Irapuato, Guanajuato, México.

Background: The prevalence of allergic diseases markedly varies according to the geographical region.

Objective: To determine the prevalence of asthma, allergic rhinitis and atopic dermatitis in children of six and seven years of age.

Methods: Cross-sectional study that included a sample of almost 15 thousand children in five cities of Mexico. Read More

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http://dx.doi.org/10.29262/ram.v65i4.527DOI Listing
January 2019
4 Reads

Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis.

Cornea 2019 Mar;38(3):344-351

Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To investigate the expression of thymic stromal lymphopoietin (TSLP) and the relevant signaling pathways in the giant papillae obtained from patients with vernal keratoconjunctivitis (VKC) and to study the potential functional role and molecular mechanism of TSLP.

Methods: Giant papillae from VKC patients and control samples were used to perform immunohistochemical staining and analyze the mRNA expression of TSLP and related pathway by real-time polymerase chain reaction.

Results: TSLP was markedly expressed in the epithelial cells and some inflammatory cells of giant papillae, but not in the control conjunctival tissue. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001832DOI Listing
March 2019
2 Reads

Rigid gas permeable contact lenses for visual rehabilitation of unilateral aphakic children in China.

Cont Lens Anterior Eye 2018 Dec 28. Epub 2018 Dec 28.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: To investigate the effectiveness, safety and tolerance of rigid gas-permeable contact lenses (RGP CLs) in the visual rehabilitation of unilateral aphakic children in China.

Methods: Records of 36 children (36 eyes) with RGP CLs to unilateral aphakia between 2014 and 2018 were evaluated. Each enrolled child underwent vision assessment (visual acuity, fixation, and deviation) at each follow-up visit and their caregivers completed a questionnaire designed to find out the reasons for RGP CLs dropout. Read More

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http://dx.doi.org/10.1016/j.clae.2018.12.009DOI Listing
December 2018
1 Read

Mycoplasma conjunctivae in insect vectors and anatomic locations related to transmission and persistence.

Vet Microbiol 2019 Jan 12;228:7-11. Epub 2018 Nov 12.

Wildlife Ecology & Health Group - Servei d' Ecopatologia de Fauna Salvatge (SEFaS), Departament de Medicina i Cirurgia, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain; UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.

Mycoplasma conjunctivae is an obligate microparasite that causes Infectious Keratoconjunctivitis (IKC) in Caprinae species. IKC is a long-recognised disease, but little attention has been paid to the mechanisms of transmission of the mycoplasma and its occurrence in locations other than the eyes. In this study, the presence of M. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183059
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http://dx.doi.org/10.1016/j.vetmic.2018.11.004DOI Listing
January 2019
6 Reads

Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study.

Clin Ophthalmol 2018 14;12:2629-2636. Epub 2018 Dec 14.

Ophthalmology Department, Paris Nord Val-de-Seine University Hospitals, Hôpital Bretonneau, Tours, France.

Background: Dry eye disease (DED) is characterized by a loss of homeostasis of the tear film. It goes along with ocular symptoms, in which ocular surface inflammation and damage play etiological roles. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory protein found in the tear fluid during conjunctivitis, blepharitis and DED. Read More

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http://dx.doi.org/10.2147/OPTH.S186074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300369PMC
December 2018
2 Reads

Phase III trials examining the efficacy of cetirizine ophthalmic solution 0.24% compared to vehicle for the treatment of allergic conjunctivitis in the conjunctival allergen challenge model.

Clin Ophthalmol 2018 13;12:2617-2628. Epub 2018 Dec 13.

Eyevance Pharmaceuticals, TX, USA,

Purpose: The purpose of these Phase III studies was to evaluate the efficacy and safety of cetirizine ophthalmic solution 0.24% compared with vehicle in the treatment of allergen-induced conjunctivitis using the Ora conjunctival allergen challenge (CAC) model.

Methods: The single-center (Study 1) and multi-center (Study 2), double-masked, randomized, vehicle-controlled, parallel group, CAC studies were conducted over ~5 weeks and four study visits. Read More

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http://dx.doi.org/10.2147/OPTH.S185835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296187PMC
December 2018
2 Reads

A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy.

J Immunother Cancer 2018 Dec 27;6(1):156. Epub 2018 Dec 27.

Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital CHUV, rue du Bugnon 46, CH-1011, Lausanne, Switzerland.

Background: The prevalence of esophageal stenosis caused by immune checkpoint inhibitors in the context of induced immune mucositis and esophagitis is extremely rare.

Case Presentation: We report the case of a patient with stage IV pulmonary adenocarcinoma treated for 6 months with nivolumab who developed bilateral sterile conjunctivitis followed by oropharyngeal mucositis and esophagitis complicated by a severe esophageal stenosis. The laryngeal margin and hypopharyngeal mucosa appeared highly inflammatory with fibrinous deposits. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
Publisher Site
http://dx.doi.org/10.1186/s40425-018-0481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307169PMC
December 2018
12 Reads