24,297 results match your criteria Conjunctivitis


Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series.

J Pediatric Infect Dis Soc 2020 May 28. Epub 2020 May 28.

Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.

We present a series of six critically ill children with Multisystem Inflammatory Syndrome in Children (MIS-C). Key findings of this syndrome include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes. Read More

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http://dx.doi.org/10.1093/jpids/piaa069DOI Listing

Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during COVID-19 Pandemic.

Indian J Pediatr 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Santi Hospital, Omassery, Calicut, Kerala, India.

There is a global concern of increasing number of children presenting with inflammatory syndrome with clinical features simulating Kawasaki disease, during ongoing COVID-19 pandemic. The authors report a very similar case of 5-y-old boy from a COVID-19 hotspot area who presented in late April 2020 with acute febrile illness with abdominal pain and loose stools followed by shock. On examination, child had bulbar conjunctivitis and extremity edema. Read More

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http://dx.doi.org/10.1007/s12098-020-03357-1DOI Listing

Very late onset corneal haze in a photorefractive keratectomy patient associated with presumed viral keratoconjuctivitis.

Indian J Ophthalmol 2020 Jun;68(6):1186-1188

Consultant Ophthalmic Surgeon, Anterior Segment Specialist, Athens Refractive Laser Center, Athens, Greece.

We report a rare case of very late-onset haze triggered by viral conjunctivitis, > 20 years after treatment of moderate myopia with photorefractive keratectomy (PRK), and its successful management. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1789_19DOI Listing

Genetic panel screening in patients with clinically unclassified systemic autoinflammatory diseases.

Clin Rheumatol 2020 May 26. Epub 2020 May 26.

Department of Pediatric Rheumatology, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Objective: Systemic autoinflammatory diseases (SAIDs) may not always present with typical clinical findings of a monogenic disease. We aimed to genetically screen and diagnose these clinically unclassified patients by next-generation sequencing (NGS) analysis.

Method: A total of 64 patients who had clinical findings of a periodic fever syndrome but did not meet the clinical diagnostic criteria for any SAID or had clinical findings for more than one monogenic SAID were identified as "clinically unclassified SAIDs. Read More

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http://dx.doi.org/10.1007/s10067-020-05108-1DOI Listing

The Ocular Manifestations and Transmission of COVID-19: Recommendations for Prevention.

J Emerg Med 2020 May 8. Epub 2020 May 8.

Department of Ophthalmology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Ophthalmology (Retina Section), Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.

Background: Coronavirus disease-2019 (COVID-19), caused by a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been linked to ocular signs and symptoms in several case reports. Research has demonstrated that SARS-CoV-2 is spread primarily through close contact via respiratory droplets, but there is the possibility for ocular transmission, with the conjunctiva as a conduit as well as a source of infection.

Discussion: Ocular manifestations of SARS-CoV-2 include follicular conjunctivitis, and have been repeatedly noted as an initial or subsequent symptom of COVID-19-positive patients. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.060DOI Listing

The use of tear ferning test in cats for evaluation of ocular surface.

Acta Vet Scand 2020 May 26;62(1):23. Epub 2020 May 26.

Department of Agrarian and Environmental Sciences, Santa Cruz State University, Rodovia Jorge Amado, Ilheus, Bahia, 45662-900, Brazil.

Background: The tear film is a trilaminar fluid composed mainly of lipids, electrolytes, proteins and water. It is responsible for lubrication, nutrition and protection against microbial and toxic agents. Disruption of any these components may weaken the ocular surface, making it more susceptible to disease. Read More

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http://dx.doi.org/10.1186/s13028-020-00523-5DOI Listing

Urgent and Emergent Eye Care Strategies to Protect Against COVID-19.

Fed Pract 2020 May;37(5):220-223

is an Optometrist and the Low Vision Director, and is an Optometrist; both at Viera VA Outpatient Clinic in Florida.

Objective: This article presents additional strategies to the medical professional and support tactics to keep both the health care provider and patient as safe as possible during the COVID-19 pandemic.

Observations: Follicular conjunctivitis has been reported as an early sign of infection or during hospitalization for severe COVID-19 disease. It has been confirmed that COVID-19 is transmitted through both respiratory droplets and direct contact. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241604PMC

Coronaviruses pathogenesis, comorbidities and multi-organ damage - A review.

Life Sci 2020 May 22:117839. Epub 2020 May 22.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu 632014, India. Electronic address:

Human coronaviruses, especially COVID-19, is an emerging pandemic infectious disease with high morbidity and mortality. Coronaviruses are associated with comorbidities, along with the symptoms of it. SARS-CoV-2 is one of the highly pathogenic coronaviruses that causes a high death rate compared to the SARS-CoV and MERS. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243768PMC

Patient-oriented Eczema Measure score: a Useful Tool for Web-Based Surveys in Patients with Atopic Dermatitis.

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan. E-mail:

The Patient-Oriented Eczema Measure (POEM, 0-28 points) is a self-assessed, repeatable measurement tool for measuring atopic dermatitis (AD) severity. How-ever, whether POEM score is influenced by allergic comorbidities and whether POEM's severity banding is applicable in web-based surveys for AD remain unclear. A web-based questionnaire survey was conducted in 329 patients with AD. Read More

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http://dx.doi.org/10.2340/00015555-3530DOI Listing

Incidence of Conjunctivitis and Other Ocular Surface Disorders in Patients with Long-Term Dupilumab Use.

J Cutan Med Surg 2020 May 25:1203475420929920. Epub 2020 May 25.

7938 Division of Dermatology, Department of Medicine, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1203475420929920DOI Listing

COVID-19 Disease and Ophthalmology: An Update.

Ophthalmol Ther 2020 May 22. Epub 2020 May 22.

Cornea, Cataract and Refractive Surgery Unit, Vissum (Grupo Miranza), Alicante, Spain.

The worldwide outbreak of the severe and acute respiratory coronavirus disease (COVID-19) caused by the coronavirus strain SARS-CoV-2 is currently the focal point of discussion due to the suffering this syndrome is causing to humanity. However, the ophthalmological implications of this syndrome has not yet been well described. Both eyes and tears as portals of entry and sources of contagion have been the subject of debate by many authors. Read More

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http://dx.doi.org/10.1007/s40123-020-00260-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243216PMC

Physician Assistant Students' Knowledge of Zika Virus: A Pilot Study.

Infect Dis (Auckl) 2020 29;13:1178633720909158. Epub 2020 Apr 29.

College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA.

Objective: The aim of this study was to assess physician assistant students' knowledge about the screening, transmission, management, and prevention of Zika virus infection.

Background: It is important for health care providers in the United States to recognize the symptoms of Zika so that they can screen, diagnose, and or treat persons exposed to or infected by the virus. Physician assistant students, on completion of their educational program and passing their board examinations, provide care for patients in primary care or specialty settings where they may treat patients who either have the virus or post-virus exposure. Read More

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http://dx.doi.org/10.1177/1178633720909158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227153PMC

Lash Impaction in Meibomian Gland Orifice.

Clin Ophthalmol 2020 7;14:1245-1247. Epub 2020 May 7.

Medical University of Lodz, Lodz, Poland.

Purpose: To analyze potential risk factors associated with eyelash impaction into meibomian gland orifice.

Methods: Retrospective review of one tertiary clinic over a period of 10 years.

Results: In this study, 18 patients were included, with a mean age of 61. Read More

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http://dx.doi.org/10.2147/OPTH.S253263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213864PMC

Ripasudil Hydrochloride Hydrate in the Treatment of Glaucoma: Safety, Efficacy, and Patient Selection.

Clin Ophthalmol 2020 6;14:1229-1236. Epub 2020 May 6.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

Reduction of intraocular pressure (IOP) is the only reliable treatment for glaucoma that maintains the patient's visual function throughout life, and IOP-lowering eyedrops are the mainstay of therapy. Ripasudil hydrochloride hydrate (brand name: Glanatec ophthalmic solution 0.4%; Kowa Company, Ltd. Read More

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http://dx.doi.org/10.2147/OPTH.S216907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212985PMC

Ocular surface disease associated with dupilumab treatment for atopic diseases.

Ocul Surf 2020 May 18. Epub 2020 May 18.

The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Dupilumab is the first US FDA approved biologic for treatment of atopic dermatitis. It is a human monoclonal antibody which blocks the shared receptor component, the interleukin (IL)-4α subunit, of IL-4 and IL-13 signaling pathways. Occurrence of "conjunctivitis", mostly in atopic dermatitis trials, has been the main side effect reported thus far. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.008DOI Listing

Pollen Proteases Play Multiple Roles in Allergic Disorders.

Int J Mol Sci 2020 May 19;21(10). Epub 2020 May 19.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

Allergic diseases are a major health concern worldwide. Pollens are important triggers for allergic rhinitis, conjunctivitis and asthma. Proteases released upon pollen grain hydration appear to play a major role in the typical immunological and inflammatory responses that occur in patients with allergic disorders. Read More

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http://dx.doi.org/10.3390/ijms21103578DOI Listing

Endocrinology in the time of COVID-19: Management of hyper- and hypo- thyroidism.

Eur J Endocrinol 2020 May 1. Epub 2020 May 1.

L Persani, IRCCS Istituto Auxologico Italiano, Universita degli Studi di Milano Dipartimento di Scienze Cliniche e di Comunita, Milano, 20149, Italy.

This manuscript provides guidance on the management of thyroid dysfunction during the COVID-19 pandemic. Auto-immune thyroid diseases are not linked to increased risks of COVID-19. Uncontrolled thyrotoxicosis may result in more severe complications from SARS-CoV-2 infection, including thyroid storm. Read More

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http://dx.doi.org/10.1530/EJE-20-0445DOI Listing

A 48-week update of a multicentre real-life experience of dupilumab in adult patients with moderate-to-severe atopic dermatitis.

J Dermatolog Treat 2020 May 21:1-9. Epub 2020 May 21.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

The long-term efficacy and safety of dupilumab has been demonstrated in clinical trials and only in few real-world studies. We conducted an extension analysis from a previous 16-week study on 109 adult patients affected by moderate-to-severe atopic dermatitis treated with dupilumab. Eczema-Area-and-Severity-Index (EASI), itch numerical-rating-score (itch-NRS), Dermatology-Life-Quality-Index (DLQI) scores, drug survival rate and occurrence of adverse events after 24 and 48 weeks of dupilumab treatment were retrospectively collected. Read More

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http://dx.doi.org/10.1080/09546634.2020.1773379DOI Listing

Heterogeneity of Adult Rhinitis for Multimorbidity and Age at Onset among Non-Sensitized Rhinitis and Mono-/Poly-Sensitized Rhinitis: A Retrospective Cross-Sectional Study.

Int Arch Allergy Immunol 2020 May 20:1-10. Epub 2020 May 20.

Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of Korea,

Background: Recent studies have proposed that clinical and immunological differences exist between mono- and poly-sensitized subjects with allergic diseases, and poly-sensitization was related to multimorbidity of allergic diseases among children and adolescents.

Objective: We compared the clinical characteristics and multimorbidity of allergic diseases between adult rhinitis patients mono- and poly-sensitized to common aeroallergens using a retrospective cross-sectional study for tertiary care subjects.

Methods: The medical records of 1,615 patients who were clinically diagnosed with rhinitis by an otolaryngologist and evaluated with skin prick tests were reviewed. Read More

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http://dx.doi.org/10.1159/000507444DOI Listing

Ophthalmology practice during the COVID-19 pandemic.

BMJ Open Ophthalmol 2020 19;5(1):e000487. Epub 2020 Apr 19.

Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel.

Objective: To present an established practice protocol for safe and effective hospital-setting ophthalmic practice during the coronavirus disease 2019 (COVID-19) pandemic.

Methods And Analysis: Literature was reviewed to identify articles relevant to COVID-19 pandemic and ophthalmology. The following keywords were used: COVID-19, SARS-CoV-2 and telemedicine, combined with eye, ophthalmology, conjunctivitis and tears. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222613PMC

Corneal melt in conjunctival intraepithelial neoplasia.

Am J Ophthalmol Case Rep 2020 Sep 20;19:100689. Epub 2020 Apr 20.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina Charleston, SC, USA.

Purpose: Report a case of corneal melt in a patient with conjunctival intraepithelial neoplasia (CIN) treated with topical interferon (IFN) alpha-2B.

Observations: An 89-year-old man presented with gelatinous paralimbal lesions of the left eye extending onto the cornea with corneal neovascularization extending 5-6 clock hours. Nasally there was mild absence of the terminal vascular loops of the limbal palisades of Vogt and conjunctivalization. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225610PMC
September 2020

NMDAR Encephalitis Associated With Acute Chikungunya Virus Infection: A New Trigger?

Front Pediatr 2020 30;8:176. Epub 2020 Apr 30.

Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil.

Anti-NMDAR encephalitis is the most frequent cause of autoimmune encephalitis. Chikungunya (CHIK) is an arbovirus responsible for outbreaks of fever, cutaneous rash and arthritis in underdeveloped countries, and a trigger for autoimmunity. We report a five-year-old male patient with fever, myalgia, headache and conjunctivitis for 5 days. Read More

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http://dx.doi.org/10.3389/fped.2020.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204150PMC

Ectoparasitism during an avian disease outbreak: An experiment with -infected house finches and ticks.

Int J Parasitol Parasites Wildl 2020 Aug 15;12:53-63. Epub 2020 Apr 15.

Laboratory of Ornithology, Cornell University, Ithaca, NY, USA.

Hosts are typically co-parasitized by multiple species. Parasites can benefit or suffer from the presence of other parasites, which can reduce or increase the overall virulence due to competition or facilitation. Outcomes of new multi-parasite systems are seldom predictable. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225381PMC

Conjunctivitis in patients with atopic dermatitis treated with dupilumab.

Drugs Context 2020 4;9. Epub 2020 May 4.

Department of Dermatology, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Atopic dermatitis (AD) is a common, chronic, inflammatory skin disorder with high physical and emotional burden. Robust evidence suggests that interleukin (IL)-4 and IL-13 are key cytokines in the immunopathogenesis of AD. New emerging agents include dupilumab, a fully human monoclonal antibody directed against the IL-4 receptor a subunit that blocks both IL-4 and IL-13 signaling and has shown significant efficacy in patients with moderate-to-severe AD. Read More

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http://dx.doi.org/10.7573/dic.2020-2-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216785PMC

Efficacy of dupilumab in atopic comorbidities associated with moderate-to-severe adult atopic dermatitis.

Allergy 2020 Apr 23. Epub 2020 Apr 23.

Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Background: Dupilumab is an anti-IL-4Rα antibody used in the treatment of patients with moderate-to-severe atopic dermatitis (msAD). This study explored the potential benefit of dupilumab in perennial allergic rhinoconjunctivitis (PAR) and perennial allergic asthma (PAA) caused by indoor allergens in adults with msAD.

Methods: This multicentric, prospective, observational, real-life study included adult patients with msAD who had been treated with dupilumab in 16 Italian care centres. Read More

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http://dx.doi.org/10.1111/all.14338DOI Listing

Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019.

Eye (Lond) 2020 May 18. Epub 2020 May 18.

Ophthalmic Epidemiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Since there are few reports on the ocular involvement of coronavirus disease 2019 (COVID-19) patients, this study aimed to assess the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in the tears of patients with COVID-19.

Methods: In this prospective case series, nasopharyngeal and tear sampling of 43 patients with severe COVID-19 were performed. The quantitative reverse transcription polymerase chain reaction (RT-PCR) was conducted to detect SARS-CoV-2. Read More

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http://dx.doi.org/10.1038/s41433-020-0965-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232592PMC

Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review.

Eye (Lond) 2020 May 18. Epub 2020 May 18.

Ophthalmology Unit, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Coronavirus disease 19 (COVID-19) has been described to potentially be complicated by ocular involvement. However, scant information is available regarding severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and ocular structures tropism. We conducted a systematic review of articles referenced in PubMed, Cochrane Library, Web of Science and Chinese Clinical Trial Register (ChiCTR) from December 20, 2019 to April 6, 2020, providing information on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears. Read More

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http://dx.doi.org/10.1038/s41433-020-0926-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232062PMC

Clinical Practice of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Asthma: An Expert Panel Report.

J Allergy Clin Immunol Pract 2020 May 15. Epub 2020 May 15.

ALK, Bedminster, NJ, USA.

Allergen immunotherapy (AIT) reduces symptoms and medication use associated with allergic rhinitis with or without conjunctivitis and allergic asthma. Although several AIT guidelines exist, there remain unanswered questions about AIT that are relevant to everyday practice. Our objective was to prepare an evidence-based overview addressing the practical aspects of AIT in clinical practice based on published evidence and the experience of international experts in the field. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.04.071DOI Listing

Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study.

Acta Ophthalmol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: To investigate the ocular manifestations and clinical characteristics of COVID-19 patients caused by SARS-CoV-2 in Wuhan, China.

Methods: A total of 535 COVID-19 patients were recruited at Mobile Cabin Hospital and Tongji Hospital. Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. Read More

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http://dx.doi.org/10.1111/aos.14472DOI Listing

Kawasaki disease presented with status epilepticus and diffusion MRI abnormalities in the subcortical white matter.

Turk J Pediatr 2020 ;62(2):315-319

Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Encephalitis/encephalopathy is an extremely rare complication of KD.

Case: A previously healthy 8-month-old Japanese boy had a prolonged seizure after febrile illness for one day. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.020DOI Listing
January 2020

COVID-19 and ophthalmology: an underappreciated occupational hazard.

Infect Control Hosp Epidemiol 2020 May 15:1-2. Epub 2020 May 15.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

The proximity required of a thorough biomicroscopic slit-lamp examination may put ophthalmologists at increased risk for respiratory-borne infection with SARS-CoV-2. Conjunctivitis has been described in a few patients with COVID-19 and other coronavirus syndromes. Although SARS-CoV-2 has been detected in the conjunctival secretions or tears of patients with COVID-19 and conjunctivitis, transmission of infection through respiratory droplets to ophthalmologists without eye protection or masks may be the bigger concern. Read More

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http://dx.doi.org/10.1017/ice.2020.238DOI Listing

Changes in corneal thickness, upper and lower tear film in seasonal allergic conjunctivitis by steroid treatment: anterior segment optical coherence tomography study.

Int Ophthalmol 2020 May 14. Epub 2020 May 14.

Department of Ophthalmology, Ondokuz Mayıs University, 55139, Samsun, Turkey.

Purpose: To evaluate the effects of loteprednol etabonate on cornea and tear film in patients with seasonal allergic conjunctivitis by anterior segment optical coherence tomography (OCT).

Methods: The right eyes of 52 subjects with seasonal allergic conjunctivitis were evaluated in the study. Central corneal thickness (CCT), the thicknesses of central corneal epithelium (CET) and central non-epithelial cornea (CnET), and lower and upper tear meniscus areas were measured by spectral-domain OCT and ocular surface disease index (OSDI) were obtained at baseline. Read More

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http://dx.doi.org/10.1007/s10792-020-01410-8DOI Listing

A non-stationary Markov model for economic evaluation of grass pollen allergoid immunotherapy.

PLoS One 2020 14;15(5):e0232753. Epub 2020 May 14.

School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Bari, Italy.

Introduction: Allergic rhino-conjunctivitis (ARC) is an IgE-mediated disease that occurs after exposure to indoor or outdoor allergens, or to non-specific triggers. Effective treatment options for seasonal ARC are available, but the economic aspects and burden of these therapies are not of secondary importance, also considered that the prevalence of ARC has been estimated at 23% in Europe. For these reasons, we propose a novel flexible cost-effectiveness analysis (CEA) model, intended to provide healthcare professionals and policymakers with useful information aimed at cost-effective interventions for grass-pollen induced allergic rhino-conjunctivitis (ARC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232753PLOS

Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct.

Acta Ophthalmol 2020 May 14. Epub 2020 May 14.

Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: The current outbreak of COVID-19 has spread rapidly all over the world. Respiratory droplets and contaction with infected patients are the two major transmission routes. However, the value of tear virus nucleic acid is still not clear. Read More

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http://dx.doi.org/10.1111/aos.14456DOI Listing

The ocular surface, coronaviruses and COVID-19.

Clin Exp Optom 2020 May 13. Epub 2020 May 13.

Centre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.

The ocular surface has been suggested as a site of infection with Coronavirus-2 (SARS-CoV-2) responsible for the coronavirus disease-19 (COVID-19). This review examines the evidence for this hypothesis, and its implications for clinical practice. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), responsible for the COVID-19 pandemic, is transmitted by person-to-person contact, via airborne droplets, or through contact with contaminated surfaces. Read More

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http://dx.doi.org/10.1111/cxo.13088DOI Listing

Molecular and phenotypic characterization of methicillin-resistant Staphylococcus pseudintermedius from ocular surfaces of dogs and cats suffering from ophthalmological diseases.

Vet Microbiol 2020 May 14;244:108687. Epub 2020 Apr 14.

Small Animal Clinic, Department of Veterinary Medicine, Freie Universität Berlin, Oertzenweg 19b, 14163 Berlin, Germany.

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) have recently emerged as a major therapeutic challenge in small animal medicine because of their antimicrobial multidrug resistance and their role as nosocomial pathogens. This study focused on the prevalence, molecular characteristics and antimicrobial resistance pheno- and genotypes of MRSP isolated from conjunctival swabs of dogs and cats. Conjunctival swabs were collected from 72 dogs and 24 cats suffering from conjunctivitis/blepharitis, keratitis or uveitis and screened for the presence of MRSP. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108687DOI Listing

[Recommendations for performing specific inhalation challenge tests: Polish experience in relation to the European Respiratory Society guideliness].

Med Pr 2020 May 6;71(3):381-397. Epub 2020 May 6.

Instytut Medycyny Pracy / Nofer Institute of Occupational Medicine, Łódź, Poland (Klinika Chorób Zawodowych i Zdrowia Środowiskowego / Department of Occupational Diseases and Environmental Health).

A diagnosis of occupational diseases implicates some medical and legal consequences; therefore, the most specific and objective methods are needed in the diagnostic process. Specific inhalation challenge (SIC) tests currently play an irreplaceable role in diagnosing allergic airway diseases (e.g. Read More

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http://dx.doi.org/10.13075/mp.5893.00924DOI Listing

Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review.

Curr Urol 2020 Mar 20;14(1):1-13. Epub 2020 Mar 20.

East and North Hertfordshire NHS Trust, Department of Urology, Lister Hospital, Stevenage.

Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by . Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing antimicrobial resistance has rendered the need for clarity over this question ever more pressing in recent years. Read More

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http://dx.doi.org/10.1159/000499266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206600PMC

[An epidemiological survey on clinical features, self-management and cognitive level of elderly asthmatics in China].

Zhonghua Yi Xue Za Zhi 2020 May;100(18):1426-1431

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate the prevalence of asthma among the elderly people in China and to analyze the clinical features, self-management and cognitive level of elderly asthma patients. According to the multi-stage random cluster sampling methods, a total of 164 215 subjects were visited by a questionnaire in the last epidemiology survey from eight provinces (Beijing, Shanghai, Guangdong, Liaoning, Henan, Shanxi, Jiangsu, Sichuan provinces) and seven regions (north, northeast, southern china, east, south, southwest and northwest) in China from February 2010 to August 2012. 2 034 were diagnosed as asthma. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191117-02498DOI Listing

Role of the Eye in Transmitting Human Coronavirus: What We Know and What We Do Not Know.

Front Public Health 2020 24;8:155. Epub 2020 Apr 24.

Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

The outbreak of the current 2019 novel coronavirus (2019-nCoV, now named SARS-CoV-2) infection has become a worldwide health threat. Currently, more information is needed so as to further understand the transmission and clinical characteristics of 2019-nCoV infection and the infection control procedures required. Recently, the role of the eye in transmitting 2019-nCoV has been intensively discussed. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193031PMC

[Are Fungal Spores Relevant Outdoor Allergens?]

Authors:
Uta Rabe

Laryngorhinootologie 2020 May 8;99(5):292-298. Epub 2020 May 8.

Zentrum für Allergologie und Asthma, Johanniter-Krankenhaus im Fläming Treuenbrietzen GmbH.

Alternaria alternata spores are important allergens causing "hayfever". Outdoor fungal exposure is primarily associated with increased asthma symptoms and increased risk of asthma exacerbations. In our outpatient-clinic, we investigated patients who presented with symptoms of allergic conjunctivitis and respiratory symptoms in the summertime. Read More

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http://dx.doi.org/10.1055/a-1071-2419DOI Listing

Dupilumab for Atopic Dermatitis: The Silver Bullet We Have Been Searching for?

Cureus 2020 Apr 6;12(4):e7565. Epub 2020 Apr 6.

Internal Medicine, Rawalpindi Medical University, Rawalpindi, PAK.

Atopic dermatitis is a chronic inflammatory condition of the skin affecting a large number of people worldwide. Historically, this condition has been managed by topical corticosteroids and general skincare measures. The inadequacy of these management strategies has always driven efforts to find better drugs. Read More

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http://dx.doi.org/10.7759/cureus.7565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202577PMC

Haemorrhagic conjunctivitis with pseudomembranous related to SARS-CoV-2.

Am J Ophthalmol Case Rep 2020 May 6:100735. Epub 2020 May 6.

Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, Witty Fit, F-63000, Clermont-Ferrand, France.

Purpose: To describe the multiplicity of ocular manifestations of COVID-19 patients, we report a case of pseudomembranous and hemorrhagic conjunctivitis related with SARS-CoV-2 pneumonia in a patient of intensive care unit (ICU).

Observations: A 63-year-old male was admitted in intensive care unit (ICU), seven days after the beginning of an influenza-like symptoms, to manage an acute respiratory syndrome related with SARS-CoV-2. Chest scan showed interstitial pneumonia with "crazy paving" patterns. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100735DOI Listing

COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic.

Klin Monbl Augenheilkd 2020 May 6;237(5):675-680. Epub 2020 May 6.

Augenklinik der LMU, Klinikum der Universität München, München, Germany.

Purpose: To perform a systematic analysis of articles on the ophthalmological implications of the global COVID-19 pandemic.

Methods: PubMed.gov was searched for relevant articles using the keywords "COVID-19", "coronavirus", and "SARS-CoV-2" in conjunction with "ophthalmology" and "eye". Read More

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http://dx.doi.org/10.1055/a-1164-9381DOI Listing

Conjunctivitis can be the only presenting sign and symptom of COVID-19.

IDCases 2020 24;20:e00774. Epub 2020 Apr 24.

DIMEC (Department of Medical and Surgical Sciences), University of Bologna, Bologna, Italy.

Five cases of non-remitting conjunctivitis turned out to be the sole presenting sign and symptom of COVID-19. These patients tested positive on RT-PCR of naso-pharyngeal swabs and developed no fever, malaise, or respiratory symptoms throughout the course of their illness. They all fully recovered. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195291PMC

Urticarial vasculitis in pediatric systemic lupus erythematosus.

Pediatr Dermatol 2020 May 5. Epub 2020 May 5.

Child Health Department, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.

Background/objectives: To determine the prevalence of urticarial vasculitis (UV) in a pediatric systemic lupus erythematosus (pSLE) cohort of Arab ethnicity from Oman and to describe their demographic, clinical, and laboratory features.

Methods: We conducted a retrospective multicenter study among pediatric rheumatology centers in Oman over a 10-year period from 2008 to 2018. Analyses were performed using univariate statistics. Read More

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http://dx.doi.org/10.1111/pde.14184DOI Listing

Functional Fibrinolysis Assays Reveal Different Mechanisms underlying Plasminogen Dysfunction in Ligneous Conjunctivitis.

Thromb Haemost 2020 May 5;120(5):758-767. Epub 2020 May 5.

Université de Paris, INSERM UMR_S1148, Paris Cedex, France.

Background:  Ligneous conjunctivitis (LC) is a rare disorder associated with plasminogen deficiency characterized by chronic fibrin deposits in the eyelids. All patients with plasminogen deficiency do not develop LC, whose underlying mechanisms remain unknown.

Objective:  We investigated whether fibrinolytic activity was correlated with phenotype and/or genotype in patients suffering from LC and their relatives. Read More

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http://dx.doi.org/10.1055/s-0040-1709526DOI Listing

Fungal Keratitis, or Misled by a Small Insect?

Turk J Ophthalmol 2020 Apr;50(2):107-109

Koç University Faculty of Medicine, Department of Ophtalmology, İstanbul, Turkey.

The pine processionary caterpillar is an insect that has multiple small, thin hairs around its body as a defense mechanism. These hairs have a hazardous effect on ocular structures and cause a broad range of reactions from conjunctivitis to endophthalmitis, referred to as ophthalmia nodosa. The diagnosis of the disease is based on the patient's history and the detection of the hairs on ocular structures. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2019.30670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204900PMC

Management of conjunctivitis during the COVID-19 pandemic 2020.

Aust J Gen Pract 2020 May 1;49. Epub 2020 May 1.

Conjunctivitis may be a feature of COVID-19, with tears containing SARS-CoV-2 virus, and a source of potential transmission via aerosols. Read More

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http://dx.doi.org/10.31128/AJGP-COVID-18DOI Listing

The influence of overnight orthokeratology on ocular surface and dry eye-related cytokines IL-17A, IL-6, and PGE2 in children.

Cont Lens Anterior Eye 2020 Apr 29. Epub 2020 Apr 29.

Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China. Electronic address:

Objective: To investigate the effect of overnight orthokeratology (OOK) on the ocular surface and dry eye-related cytokines in children.

Methods: A non-randomized, prospective pilot study was conducted including sixty myopes treated with OOK and sixty age-matched spectacle wearing participants. The following tests were performed before and after 1, 3, 6 and 12 months: ocular surface disease index (OSDI), noninvasive tear breakup time (NITBUT), tear meniscus height (TMH), corneal fluorescein staining (CFS), meiboscore using noncontact meibography. Read More

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http://dx.doi.org/10.1016/j.clae.2020.04.001DOI Listing
April 2020
2.000 Impact Factor