2,431 results match your criteria Conization of Cervix


Making the invisible visible: improving detectability of MRI-invisible residual cervical cancer after conisation by DCE-MRI.

Clin Radiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Aim: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) quantitative parameters increase the detectability of MRI-invisible residual cervical cancer after conisation.

Materials And Methods: This retrospective study included 59 patients with MRI-invisible cervical cancer, but positive conisation pathology. Thirty-five patients were confirmed to have residual cervical cancer, and 24 patients showed non-residual cervical cancer. Read More

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November 2018

[Establishment of a prognostic model for preterm delivery in women after cervical conization].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):351-356

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To establish a prognostic model for preterm birth in women after cervical conization, and to evaluate its effectiveness.

Methods: Seventy three women after cervical conization in Women's Hospital of Zhejiang University were included for this retrospective study. The influencing factors of preterm delivery were analyzed by Logistic regression analysis and a prognostic model was created. Read More

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February 2018

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13420

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.

Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.

Patient Concerns: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. Read More

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November 2018

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13418

Department of Gynecology.

Rationale: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.

Patient Concerns: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. Read More

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November 2018

Nomogram-based prediction of cervical dysplasia persistence/recurrence.

Eur J Cancer Prev 2018 Nov 26. Epub 2018 Nov 26.

Department of Gynecologic Oncology.

The widespread introduction of screening methods allow to identify cervical dysplasia before having invasive cancer. The risk of developing cervical dysplasia persistence/recurrence following conization represent a major health issue. Although several studies tried to identify predictors for cervical dysplasia persistence/recurrence, no previous study has been conducted to develop a risk calculator. Read More

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November 2018
4 Reads

Detection of tumor cells of serous tubal intraepithelial carcinoma (STIC) in cervical smears and rapid development of the ovarian involvement: A case report.

Diagn Cytopathol 2018 Nov 30;46(11):945-949. Epub 2018 Oct 30.

Department of Gynecology, Shiga General Hospital, Moriyama, Shiga, Japan.

Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Read More

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November 2018
1 Read

Adherence to gynecological screening impacted by experienced orthodontic treatment in childhood.

Arch Gynecol Obstet 2018 Oct 30. Epub 2018 Oct 30.

Poliklinik für Kieferorthopädie, Universitätsklinik Tübingen, Tübingen, Germany.

Background: Dental and cervical controls are two established screening programs in Germany. Compliance to orthodontic treatment in childhood is essential for dental health and one of the first health interventions that requires adherent behavior; therefore, it may be associated with participation in further screening programs in adulthood. However, it is not yet known whether early orthodontic treatment influences long-term screening adherence. Read More

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October 2018
5 Reads

Risk Factor Analysis of Persistent High-Grade Squamous Intraepithelial Lesion After Loop Electrosurgical Excision Procedure Conization.

J Low Genit Tract Dis 2018 Oct 26. Epub 2018 Oct 26.

Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Objective: The aim of the study was to analyze the clinical outcomes of high-grade squamous intraepithelial lesion (HSIL) 6 months after loop electrosurgical excision procedure (LEEP). We explored the risk factors of persistent cervical HSIL after LEEP and evaluated the methods of follow-up.

Patients And Methods: This retrospective study included women who underwent a LEEP and had a diagnosis of HSIL in their LEEP specimen during 2011 to 2015. Read More

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October 2018
2 Reads

Accuracy of colposcopy-directed biopsy in detecting early cervical neoplasia: a retrospective study.

Arch Gynecol Obstet 2018 Oct 27. Epub 2018 Oct 27.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen/European Metropolitan Area Nuremberg (CCC ER-EMN), Universitätsstrasse 21-23, 91052, Erlangen, Germany.

Purpose: Colposcopy-directed biopsy is a cornerstone method for diagnosing cervical intraepithelial neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with definitive surgery.

Methods: The accuracy of colposcopy-directed biopsy was compared with the final histology in relation to different types of transformation zone (TZ), the patient's age, and the examiner's level of training. Read More

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October 2018
4 Reads

Risk factors of persistent HPV infection after treatment for high-grade squamous intraepithelial lesion.

Arch Gynecol Obstet 2018 Oct 19. Epub 2018 Oct 19.

Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, College of Medicine, Dankook University, 17, Seoae-ro 1-gil, Jung-gu, Seoul, 04619, Republic of Korea.

Purpose: To evaluate the risk factors associated with persistent high-risk human papillomavirus (HR HPV) infections in patients undergoing cervical excision for treatment of high-grade squamous intraepithelial lesion (HSIL).

Methods: A retrospective cohort study included 160 patients who underwent cervical excision for treatment of HSIL between January 2014 and December 2014. The clinical characteristics, cervical cytology, and HPV test results were reviewed. Read More

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October 2018
5 Reads
1.280 Impact Factor

Value of serial cervical length measurement in prediction of spontaneous preterm birth in post-conization pregnancy without short mid-trimester cervix.

Authors:
Liang Wang

Sci Rep 2018 Oct 17;8(1):15305. Epub 2018 Oct 17.

Department of Ultrasound, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, 1 Shuaifuyuan Wangfujing, Beijing, 100730, China.

Serial cervical length (CL) measurement in mid-trimester is recommended in post-conization pregnancy to estimate the risk of spontaneous preterm birth (SPTB). A short mid-trimester cervix (CL < 25 mm) has been considered as a strong predictor for SPTB. However, the low incidence of short cervix limits the utility of mid-trimester CL measurement in prediction of SPTB. Read More

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October 2018
1 Read

The risk factors of residual lesions and recurrence of the high-grade cervical intraepithelial lesions (HSIL) patients with positive-margin after conization.

Medicine (Baltimore) 2018 Oct;97(41):e12792

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University.

The aim of this study was to illuminate risks factors of residual lesions, and recurrence of the high-grade cervical intraepithelial lesions (HSIL) patients with positive margin who underwent cervical conization.A retrospective cohort study of 218 patients with positive margin after conization, including cold knife conization (CKC) and loop electrosurgical excisional procedure (LEEP), and follow-up from 2013 through 2016. The diagnosis of residual disease and recurrence were established and confirmed by biopsy. Read More

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October 2018
1 Read

An electrical scalpel conization versus Shimodaira-Taniguchi conization procedure for cervical intraepithelial neoplasia.

Medicine (Baltimore) 2018 Oct;97(41):e12640

Tone-Chuo-Hospital, Japan.

The incidence of cervical intraepithelial neoplasia(CIN) among reproductive-aged women has increased in Japan. Cervical conization is commonly applied for local cervical treatment to preserve fertility. The Shimodaira-Taniguchi (S-T) conization procedure is widely used in Japan. Read More

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October 2018
1 Read

[Study of conizations of the cervix after five years of cervical cancer screening with co-testing].

Rev Esp Salud Publica 2018 Oct 2;92. Epub 2018 Oct 2.

Atención Primaria del Sector Barbastro. Barbastro. Huesca. España.

Objective: Uterine Cervical Cancer (UCC) screening has changed with the introduction of the High Risk Human Papilloma Virus test (HRHPV) and its evaluation is necessary. The objective of this study is to analyze the effectiveness of UCC screening with activities aimed at early detection and treatment to modify the natural history of the process and improve its prognosis.

Methods: Cytology and HR-HPV (co-testing) were performed according to the SEGO protocol of 2010 between 2011 and 2015 with follow-up until 2017. Read More

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October 2018
2 Reads

Comparison of Electrosurgical Devices for Cervical Conization: Novel Monopolar Scalpel (VIO) Versus Ultrasonic Scalpel.

J Low Genit Tract Dis 2018 Sep 26. Epub 2018 Sep 26.

Gynecology Service, National Kyushu Cancer Center, Fukuoka, Japan.

Objective: The aim of this study was to compare the outcomes associated with the use of a novel monopolar scalpel with those associated with the use of an ultrasonic scalpel for cervical conization of cervical intraepithelial neoplasia.

Materials And Methods: We conducted a retrospective cross-sectional study in patients treated in our institute between April 2010 and March 2017. We used either the VIO monopolar scalpel (VIO) or Harmonic ultrasonic scalpel (HS) for cervical conization. Read More

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September 2018
8 Reads

The use of colposcopic punch biopsy in the management of abnormal cervical cytology: a 5-year retrospective audit.

J Obstet Gynaecol 2018 Sep 19:1-5. Epub 2018 Sep 19.

a Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine , Istanbul University , Istanbul , Turkey.

The aim of this study was to determine the accuracy of colposcopic punch biopsy to detect cervical epithelial neoplasia (CIN) II + in patients with abnormal cervical cytology and the major colposcopic findings in patients who underwent a loop electrosurgical excision procedure (LEEP), subsequently. A total of 231 patients with abnormal cervical cytology who underwent a colposcopy guided cervical biopsy and subsequent LEEP were analysed. The mean age was 33. Read More

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September 2018
1 Read
0.600 Impact Factor

The Clearance of High-Risk Human Papillomavirus is Sooner After Thin Loop Electrosurgical Excision Procedure (t-LEEP).

J Invest Surg 2018 Sep 13:1-6. Epub 2018 Sep 13.

a Department of Gynecology , Changning Maternity and Infant Health Hospital , Shanghai , China.

Purpose/aim of the study: To investigate high-risk human papillomavirus (HPV) infection clearance following thin loop electrosurgical excision procedure (t-LEEP) among patients with cervical benign lesion.

Materials And Methods: This retrospective study analyzed clinical data from patients with cervical benign lesion and HPV infection, who had undergone t-LEEP (T-Group), compared with patients with HPV infection undergone no treatment (NT-Group). Both groups attended regular follow-up between January 2008 and January 2012. Read More

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September 2018
2 Reads

Haemodynamic stability after paracervical block: A randomized, controlled, double-blind study comparing bupivacaine-adrenaline with bupivacaine.

Acta Anaesthesiol Scand 2018 Sep 10. Epub 2018 Sep 10.

Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Background: Paracervical block is widely used in gynaecological interventions on cervix and uterus. Many surgeons add adrenaline 100 μg or pitressin 3-5 IU in a total volume of 10-20 mL to reduce total blood loss. We wanted to examine haemodynamic stability in healthy patients given bupivacaine with and without adrenaline. Read More

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September 2018
1 Read

Transvaginal cervicoisthmic cerclage for patients with extremely high-risk history of preterm delivery.

J Obstet Gynaecol Res 2018 Sep 6. Epub 2018 Sep 6.

Department of Obstetrics and Gynecology, Showa University Koto Toyosu Hospital, Tokyo, Japan.

Transvaginal cervicoisthmic cerclage was carried out in 12 such patients who were at high-risk of premature delivery. Patients who underwent transvaginal cervicoisthmic cerclage had undergone conization, cervical radical hysterectomy or another form of extensive cervical resection, or had a history of third-trimester miscarriage or premature delivery despite having previously undergone cervical cerclage several times for cervical incompetence. There were seven cases of pregnancy after extensive conization, and four had a history of failed cervical cerclage. Read More

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September 2018
7 Reads

Low proportion of unreported cervical treatments in the cancer registry of Norway between 1998 and 2013.

Acta Oncol 2018 Aug 31:1-8. Epub 2018 Aug 31.

a Department of Research , Cancer Registry of Norway , Oslo , Norway.

Background: Accurate information about treatment is needed to evaluate cervical cancer prevention efforts. We studied completeness and validity of reporting cervical treatments in the Cancer Registry of Norway (CRN).

Material And Methods: We identified 47,423 (92%) high-grade cervical dysplasia patients with and 3983 (8%) without recorded treatment in the CRN in 1998-2013. Read More

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August 2018
1 Read

Residual lesions in uterine specimens after loop electrosurgical excision procedure in patients with CIN.

Arch Gynecol Obstet 2018 Oct 30;298(4):805-812. Epub 2018 Aug 30.

Department of Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, 910 Hengshan Road, Shanghai, 200030, China.

Objective: To identify the risk factors for residual lesion in hysterectomy specimens after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN).

Methods And Results: We retrospectively analyzed the clinical data of 594 patients who underwent total hysterectomy after LEEP for CIN at the International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiaotong University between July 2006 and June 2015. Among the 594 patients, there were no residual lesions in uterine specimens of 409 (68. Read More

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October 2018
2 Reads

Comparative analysis of transcervical resection and loop electrosurgical excision in the treatment of high-grade cervical intraepithelial neoplasia.

Int J Gynaecol Obstet 2018 Dec 6;143(3):306-312. Epub 2018 Sep 6.

Department of Obstetrics and Gynecology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Objective: To compare the efficacy of transcervical resection of the cervix (TCRC) and loop electrosurgical excision procedure (LEEP) in the treatment of high-grade cervical squamous intraepithelial lesions (HSIL).

Methods: A retrospective case record review was conducted of patients with HSIL treated with TCRC or LEEP at Guangdong General Hospital, Guangdong Academy of Medical Sciences and Zhujiang Hospital, Guangzhou, China, from 2009 to 2015. The clinical characteristics, cone margin statuses, clinical outcomes, and adverse events were compared between the two groups. Read More

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December 2018
4 Reads

Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature.

Taiwan J Obstet Gynecol 2018 Aug;57(4):479-482

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Japan.

Objective: To assess the clinicopathological characteristics and clinical management of patients diagnosed with mullerian adenosarcoma of the uterine cervix.

Materials And Methods: Records of six patients surgically treated for cervical mullerian adenosarcoma were reviewed.

Results: The median age of the patients was 50 years (range, 17-74). Read More

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August 2018
7 Reads

Impact of a cervical dysplasia and its treatment on quality of life and sexual function.

Arch Gynecol Obstet 2018 Oct 3;298(4):737-745. Epub 2018 Aug 3.

Department of Obstetrics and Gynecology, University Hospital Heidelberg, Im Neuenheimer Feld 440, Heidelberg, Germany.

Purpose: In this case-control study, the impact on quality of life and sexual function in women with cervical dysplasia and conization will be evaluated, in order to address coping with such a premalignant lesion and to improve strategies for salutogenesis.

Methods: This multicenter case-control study evaluates women at special dysplasia outpatient clinic (T1) as well as 3 (T2) and 6 (T3) months after the diagnosis of a dysplasia. The women were subgrouped upon dysplasia only (S2) or dysplasia with conization (S1). Read More

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October 2018
3 Reads

Loop electrosurgical excision procedure with or without intraoperative colposcopy: a randomized trial.

Am J Obstet Gynecol 2018 Oct 29;219(4):377.e1-377.e7. Epub 2018 Jul 29.

Department of Obstetrics and Gynecology, Ruhr-Universität Bochum, Bochum, Germany.

Background: Loop electrosurgical excision procedure is the standard surgical treatment for cervical dysplasia. Loop electrosurgical excision procedure is advised to be performed under colposcopic guidance to minimize adverse pregnancy outcomes. To date, there is no evidence from randomized trials for this recommendation. Read More

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October 2018
17 Reads

Long-Term Oncologic Outcomes of Uterine-Preserving Surgery in Young Women With Stage Ib1 Cervical Cancer.

Int J Gynecol Cancer 2018 Sep;28(7):1350-1359

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

Objective: This study aimed to evaluate oncologic outcomes of women with stage IB1 cervical cancer treated with uterine-preserving surgery (UPS) (defined as conization or trachelectomy) versus non-UPS (defined as hysterectomy of any type).

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women younger than 45 years diagnosed with stage IB1 cervical cancer from 1998 to 2012. Only those who underwent lymph node (LN) assessment were included. Read More

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September 2018
5 Reads

Conservative management of cervical cancer: Current status and obstetrical implications.

Best Pract Res Clin Obstet Gynaecol 2018 Jun 28. Epub 2018 Jun 28.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Recent advances in screening and early diagnosis have decreased cervical cancer incidence and mortality rates in high-resource settings. The postponement of childbearing, combined with an increased number of cervical cancer survivors, has yielded new paradigms in patient care. In recent years, radical surgery has been challenged as the standard of care for early-stage cervical cancer owing to its significant morbidity and fertility impairment. Read More

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June 2018
3 Reads
3.000 Impact Factor

Clinical factors that affect diagnostic discrepancy between colposcopically directed biopsies and loop electrosurgical excision procedure conization of the uterine cervix.

Obstet Gynecol Sci 2018 Jul 28;61(4):477-488. Epub 2018 Jun 28.

Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.

Objective: This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP).

Methods: Between 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervical cytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. Read More

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July 2018
3 Reads

The use of p16/Ki-67 dual staining technology on cervical cytology of patients undergoing a LLETZ procedure.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 21;228:191-196. Epub 2018 Jun 21.

Department of Pathology - University Hospitals of Leuven, Herestraat 49, Leuven, Belgium.

Objectives: The main objective of this prospective observational study was to investigate the diagnostic performance of the p16/Ki-67 dual stain technique (DST) for detecting CIN 2+ in a LLETZ referral setting. Test performances were compared with HR-HPV testing and Pap cytology.

Methods: All patients referred for a LLETZ procedure were candidates for participation in this trial. Read More

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September 2018
1 Read

Cerclage is associated with the increased risk of preterm birth in women who had cervical conization.

BMC Pregnancy Childbirth 2018 Jul 3;18(1):277. Epub 2018 Jul 3.

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.

Background: The aim of this study was to determine the effect of cerclage in women who underwent cervical conization.

Methods: Study data were collected from the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service for 2009-2013. Women who had a conization in 2009 and a subsequent first delivery between 2009 and 2013 in Korea were enrolled. Read More

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July 2018
11 Reads

ESGO Survey on Current Practice in the Management of Cervical Cancer.

Int J Gynecol Cancer 2018 Jul;28(6):1226-1231

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic.

Objective: The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages.

Materials And Methods: A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance. Read More

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July 2018
5 Reads

Effects of cervical conisation on pregnancy outcome: a meta-analysis.

J Obstet Gynaecol 2018 Jun 8:1-8. Epub 2018 Jun 8.

b Prenatal Diagnosis Center , Zhangzhou Affiliated Hospital of Fujian Medical University , Zhangzhou , China.

To assess the effect of cervical conisation on pregnancy outcome, a literature search strategy was conducted to identify all of the references lists of the relevant studies. The fixed or random effect model was used to calculate pooled RRs on the basis of heterogeneity. Twenty-seven publications with n cases and m controls were included in the meta-analysis. Read More

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June 2018
6 Reads

A Large Retrospective Study of 12714 Cases of LEEP Conization Focusing on Cervical Cancer That Colposcopy-Directed Biopsy Failed to Detect.

Biomed Res Int 2018 30;2018:5138232. Epub 2018 Apr 30.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Punch biopsy is important in the diagnosis of cervical cancer. However, it may fail to detect early cervical cancers. A retrospective study was performed in the largest academic women's hospital in China to demonstrate cervical cancer that colposcopy-directed biopsy failed to detect. Read More

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October 2018
5 Reads

Less versus more radical surgery in stage IB1 cervical cancer: A population-based study of long-term survival.

Gynecol Oncol 2018 07;150(1):44-49

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Standard surgical treatment for women with stage IB1 cervical cancer consists of radical hysterectomy. This study assesses survival outcomes of those treated with less radical surgery (LRS; conization, trachelectomy, simple hysterectomy) compared to more radical surgery (MRS; modified radical, radical hysterectomy).

Methods: Using the Surveillance, Epidemiology and End Results database, we identified women <45 years with FIGO stage IB1 cervical cancer diagnosed from 1/1998 to 12/2012. Read More

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July 2018
7 Reads

Predicting factors for resumption of spontaneous voiding following nerve-sparing radical hysterectomy.

J Gynecol Oncol 2018 Jul 23;29(4):e59. Epub 2018 Apr 23.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: To determine factors affecting voiding recovery on the day of Foley catheter removal (postoperative day 7, POD7) after nerve-sparing radical hysterectomy (NSRH) for early-stage cervical cancer.

Methods: Early-stage cervical cancer patients, who underwent type C1 radical hysterectomy between January 2006 and June 2016 were included. Clinical and pathological data were reviewed. Read More

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July 2018
3 Reads

Risks of cervical intraepithelial neoplasia grade 3 or invasive cancers in ASCUS women with different management: a population-based cohort study.

J Gynecol Oncol 2018 Jul 20;29(4):e55. Epub 2018 Mar 20.

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Objective: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements.

Methods: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model. Read More

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July 2018
7 Reads

Is the ovarian preservation safe in young women with stages IB-IIA villoglandular adenocarcinoma of the uterine cervix?

J Gynecol Oncol 2018 Jul 20;29(4):e54. Epub 2018 Mar 20.

Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.

Objective: Because villoglandular adenocarcinoma (VGA) of the uterine cervix has favorable features and outcomes, patients receive less radical surgery and young women preserve their ovaries. We aimed to evaluate the clinicopathological features and outcomes of VGA and to see if the ovarian preservation is safe in young women with VGA.

Methods: We retrospectively reviewed medical records and identified patients with VGA, who had been treated and followed from January 2004 to December 2015. Read More

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July 2018
3 Reads

The use of conization to identify and treat severe lesions among prediagnosed CIN1 and 2 patients in Japan.

J Gynecol Oncol 2018 Jul 8;29(4):e46. Epub 2018 Mar 8.

Department of Obstetrics and Gynecology, Kumamoto University, Faculty of Life Sciences, Kumamoto, Japan.

Objective: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan.

Methods: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics. Read More

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July 2018
4 Reads

Factors affecting residual/recurrent cervical intraepithelial neoplasia after cervical conization with negative margins.

J Med Virol 2018 Sep 25;90(9):1541-1548. Epub 2018 May 25.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

To identify factors for predicting residual or recurrent cervical intraepithelial neoplasia (CIN) after cervical conization with negative margins. A total of 172 patients with histologically verified high-grade squamous intraepithelial lesions who underwent conization with negative margins were recruited at the General Hospital of Tianjin Medical University from December 2006 to January 2016. Follow-up comprised clinical examination, a liquid-based cytology test, a human papillomavirus (HPV) DNA genotyping test, colposcopy assessment, and if indicated, colposcopy-directed punch biopsy. Read More

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September 2018
2 Reads

[The new S3 guideline "Prevention of cervical carcinoma" : What is important for pathology?]

Authors:
D Schmidt

Pathologe 2018 May;39(3):269-279

Institut für Pathologie und Zytologie, Gereonstr. 14a, 41747, Viersen, Deutschland.

Of the numerous aspects involved in the diagnosis, treatment, and follow-up of cervical uterine precursor lesions, epidemiology, virology, cytology, human papillomavirus (HPV) testing, and diagnostic algorithms for equivocal and HPV-positive findings are important for pathologists. Cytology will continue to be used as a preventive medical check-up in young women, while HPV-based screening is suggested for older women. HPV screening has yielded a significant reduction in cancer precursors and invasive cervical carcinoma in numerous studies. Read More

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Factors That Influence Surgical Margin State in Patients Undergoing Cold Knife Conization - A Single Center Experience.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):113-120

Institute for Pathology, Medical Faculty Skopje, University "Ss. Cyril and Methodius", Skopje, Republic of Macedoniats.

Aim: To evaluate the factors that influence the surgical margin state in patients undergoing cold knife conization at the University Clinic of Gynecology and Obstetrics in Skopje, Republic of Macedonia Materials and methods: We have retrospectively analyzed the medical records of all patients that underwent a cold knife conization at our Clinic in 2015. We cross-referenced the surgical margin state with the histopathological diagnosis (LSIL, HSIL or micro-invasive/invasive cancer), menopausal status of the patients, number of pregnancies, surgeon experience, operating time and cone depth. The data was analyzed with the Chi square test, Fisher's exact test for categorical data and Student's T test for continuous data and univariate and multivariate logistical regressions were performed. Read More

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December 2017
7 Reads

Incidence Trends of Cervical Cancer and Its Precancerous Lesions in Women of Central Switzerland from 2000 until 2014.

Front Med (Lausanne) 2018 16;5:58. Epub 2018 Mar 16.

Department of Obstetrics and Gynecology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.

Objective: Cervical cancer (CC) screening by Pap smears has led to a decrease in the incidence of CC worldwide. Indeed, the incidence of CC in Switzerland is very low; however, there is a lack of data to evaluate the efficiency of the Pap smear as a screening tool. Until now, only Pap smears have been used and other methods such as the presence of an infection with HPV have not been integrated into the routine screening. Read More

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March 2018
1 Read

[Clinical significance of loop electrosurgical excisional procedure in diagnosis and treatment of cervical adenocarcinoma in situ and invasive cervical adenocarcinoma].

Zhonghua Fu Chan Ke Za Zhi 2018 Mar;53(3):178-182

Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

To evaluate the accuracy of colposcopic biopsy on diagnosis of cervical adenocarcinoma in situ (AIS) and the clinical significance of loop electrosurgical excisional procedure (LEEP) on diagnosis and treatment of AIS and invasive adenocarcinoma. All medical records of 193 patients diagnosed as AIS by colposcopic biopsy and (or) AIS or invasive adenocarcinoma diagnosed by LEEP conization from Jan. 2015 to Dec. Read More

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March 2018
10 Reads

Influence of training level on cervical cone size and resection margin status at conization: a retrospective study.

Arch Gynecol Obstet 2018 Jun 30;297(6):1517-1523. Epub 2018 Mar 30.

Department of Gynecology and Obstetrics, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objective: To explore whether a surgeon's training level influences the rate of incomplete resections or the amount of resected cervical tissue in women treated with large loop excision of the transformation zone (LLETZ).

Methods: The present study is a retrospective analysis of the data of women who had undergone LLETZ for cervical intraepithelial neoplasia (CIN) within the years 2004-2008 at the Medical University of Vienna. Women were grouped according to the level of training of the operating surgeon (i. Read More

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June 2018
4 Reads

Natural History of Squamous Intraepithelial Lesions in Pregnancy and Mode of Delivery.

Anticancer Res 2018 04;38(4):2439-2442

Department of Obstetrics and Gynecology, General Hospital Vienna, Medical University Vienna, Vienna, Austria

Background: Numerous studies have addressed the impact of mode of delivery on the natural history of squamous intraepithelial lesions (SIL) in pregnant women. However, the literature is still contradictory.

Patients And Methods: In the course of a retrospective analysis, data of 63 pregnant women with abnormal cervical smears who were referred to our Outpatient Department for pre-invasive lesions of the cervix were analyzed. Read More

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April 2018
8 Reads

Effect of age and cone dimensions on cervical regeneration: an Italian multicentric prospective observational study.

BMJ Open 2018 03 19;8(3):e020675. Epub 2018 Mar 19.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objectives: To evaluate cervical regeneration at 6 months following excisional treatment for high-grade cervical intraepithelial neoplasia (CIN), and to investigate the effect of cone dimensions, age of patients and technique of excision on the efficacy of the regeneration process.

Design: Prospective observational multicentric study.

Setting: Three tertiary care and research centres. Read More

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March 2018
8 Reads

Incidence of Lymph Node Metastases in Women With Low-Risk Early Cervical Cancer (<2 cm) Without Lymph-Vascular Invasion.

Int J Gynecol Cancer 2018 May;28(4):788-793

Objective: To determine the incidence of lymph node metastasis in women with low-risk cervical cancer stage IA2 or IB1 (<2 cm) without lymph-vascular space invasion.

Methods: A multicenter retrospective study was performed in patients who underwent radical or simple hysterectomy, conization, or trachelectomy plus pelvic lymphadenectomy for cervical cancer between January 2000 and June 2016.

Results: A total of 271 patients were included in the study. Read More

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May 2018
5 Reads

Psychosexual outcomes in women of reproductive age at more than two-years from excisional cervical treatment - a cross-sectional study.

J Psychosom Obstet Gynaecol 2018 Mar 12:1-10. Epub 2018 Mar 12.

a School of Medicine , University of Belgrade , Belgrade , Serbia.

Purpose: To investigate the long-term psychosexual outcomes in women following excisional cervical treatment.

Materials And Methods: Women with cold-knife conization (CKC) or large loop excision of the transformation zone (LLETZ) treatment were interviewed after a follow-up colposcopy visit. Their demographics, treatment and psychosexual characteristics were recorded. Read More

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March 2018
3 Reads

The Clinical Significance of HPV Type in Women with Recurrent Cytological Atypia.

Isr Med Assoc J 2018 Mar;20(3):172-175

Department of Community Medicine, Women's Health Center, Maccabi Healthcare Services, Tel Aviv, Israel.

Background: The human papillomavirus (HPV) test has proven to be efficient in triaging women with abnormal Pap findings in women with low cytological atypia, but there is no data about the accuracy for large loop excision of transformation zone in cases of recurrent atypia.

Objectives: To assess the clinical correlation between results of HPV typing and conization histology in women who had recurrent abnormal Pap test results with no colposcopy findings.

Methods: Our retrospective cohort study included 138 women enrolled in the Maccabi Healthcare Services who had consecutive atypical Pap test results for 2 years in which no abnormal colposcopic findings were detected. Read More

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March 2018
3 Reads

Simple Hysterectomy for Residual Cervical Intraepithelial Neoplasm.

J Low Genit Tract Dis 2018 Apr;22(2):126-128

Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Many patients undergo hysterectomy for the treatment of cervical dysplasia. Factors that correlate with residual high-grade squamous intraepithelial lesions (HGSIL) at hysterectomy are not clear. We set out to determine preoperative features that may predict residual disease for patients treated for cervical dysplasia. Read More

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April 2018
7 Reads