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J Med Case Rep 2022 May 20;16(1):196. Epub 2022 May 20.

Department of Obstetrics and Gynecology, Hospital de Denia, Avenida Marina alta, s/n, 03700, Denia, Alicante, Spain.

Background: The spread of cervical squamous cell carcinoma to the inner surface of the uterus with replacement of the endometrium is rare. Continuity of the lesion must be demonstrated to confirm superficial spread and rule out concomitant endometrial cancer.

Case Presentation: We present the case of a 66-year-old white woman with superficial spreading squamous cell carcinoma of the cervix that involved the endometrium. Read More

Rev Bras Ginecol Obstet 2022 Mar 16;44(3):272-279. Epub 2022 May 16.

Department of Gynecology and Obstetrics, Lower Genital Tract Disease and Colposcopy Sector, Clinics Hospital of the University of Paraná, Curitiba, PR, Brazil.

Objective:  To evaluate whether colposcopy-directed biopsy is necessary to increase the accuracy of diagnosing cervical intraepithelial lesions in relation to colposcopy.

Methods:  We performed a retrospective, observational study by analyzing medical records obtained from Hospital de Clínicas do Paraná from February 2008 to February 2018. Patients with results of Pap tests, colposcopy, colposcopy-directed biopsy, and surgical procedures (high-frequency surgery or cold conization) were included. Read More

Int J Gynaecol Obstet 2022 Apr 27. Epub 2022 Apr 27.

Gynecological Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Objective: To analyze the clinical management, the outcomes, and the trend in hysterectomy rates (HR) in patients who underwent this procedure for cervical intraepithelial neoplasia (CIN).

Methods: Multicentric retrospective observational study conducted on 242 patients who underwent hysterectomy for CIN between 2010 and 2020 in nine Italian institutions. Hysterectomy for invasive or micro-invasive neoplasia, sub-total hysterectomy, or trachelectomy were excluded. Read More

Acta Obstet Gynecol Scand 2022 Apr 26. Epub 2022 Apr 26.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: In this review and meta-analysis we aimed to investigate whether human papilloma virus (HPV) vaccination administered after excisional treatment of cervical intraepithelial neoplasia (CIN) is associated with a reduced risk of recurrence of CIN grade 2 or worse (CIN2+).

Material And Methods: We performed a systematic literature search in three online databases through June 2021. Observational studies and randomized controlled trials (RCTs) were eligible for inclusion if the prophylactic HPV vaccine was administered after excisional treatment for histologically verified CIN. Read More

Vaccines (Basel) 2022 Apr 9;10(4). Epub 2022 Apr 9.

Department of Woman's and Child's Health, Obstetrics and Gynecological Unit, San Camillo-Forlanini Hospital, 00152 Rome, Italy.

Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. Read More

Int J Gynecol Pathol 2022 Apr 12. Epub 2022 Apr 12.

High-risk human papillomavirus (HPV) persistent infection is the major tumorigenesis factor for cervical cancer (CC). However, the incidence of HPV-negative CC is 5% to 30% with different HPV detection methods. High-risk HPV E6/E7 mRNAin situhybridization (RISH) can detect HPV-driven tumors. Read More

Ann Surg Oncol 2022 Apr 19. Epub 2022 Apr 19.

Department of Gynecology, Clinica Universidad de Navarra, Pamplona, Spain.

Ann Surg Oncol 2022 Apr 16. Epub 2022 Apr 16.

Department of Gynecology, Clinica Universidad de Navarra, Pamplona, Spain.

Objective: Based on the SUCCOR study database, our primary objective was to identify the independent clinical pathological variables associated with the risk of relapse in patients with stage IB1 cervical cancer who underwent a radical hysterectomy. Our secondary goal was to design and validate a risk predictive index (RPI) for classifying patients depending on the risk of recurrence.

Methods: Overall, 1116 women were included from January 2013 to December 2014. Read More

Arch Gynecol Obstet 2022 Apr 14. Epub 2022 Apr 14.

Department of Gynecology, University of Duesseldorf, Duesseldorf, Germany.

Purpose: High grade cervical intraepithelial neoplasia (CIN2+) may progress to cervical cancer. They may be detected by screening and are usually treated by conization. This study aimed at assessing annual proportions of screening, prevalent and incident CIN2+ diagnoses, as well as proportions of (re-)conizations during 24 months follow-up after conization in Germany. Read More

Open Forum Infect Dis 2022 May 13;9(5):ofac013. Epub 2022 Jan 13.

Department of Gynecology, Xiangya Hospital, Central South University, Changsha, China.

Background: The colposcopy-conization inconsistency is common in women with cervical intraepithelial neoplasia grade 3 (CIN3). No adequate method has been reported to identify the final pathology of conization. In this study, we explored the ability of PAX1 and ZNF582 methylation to predict the pathological outcome of conization in advance. Read More

Sex Med Rev 2022 Apr 7. Epub 2022 Apr 7.

Department of Obstetrics and Gynecology, George Washington University, Washington, DC, USA.

Introduction: Cervical cancer is the fourth most common cancer worldwide and accounted for approximately 570,000 new cancer cases and 311,000 cancer deaths in 2018. Despite advances in screening algorithms many US women undergo excisional cervical procedures for the treatment of cervical dysplasia. The effects of loop electrosurgical excisional procedure (LEEP) and cold knife conization (CKC) on sexual function are relatively unknown. Read More

Gynecol Oncol 2022 Jun 7;165(3):472-477. Epub 2022 Apr 7.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark. Electronic address:

Objective: To examine the absolute risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) following conization according to post-conization HPV status and surgical margins.

Methods: A total of 11,006 women with CIN3 on the cone were followed for up to 14 years using nationwide registries. We estimated absolute risks of recurrent CIN2+ and sensitivity and specificity of HPV testing and margin status in predicting CIN2+ 4 years after conization. Read More

Int J Gynecol Cancer 2022 Mar 30. Epub 2022 Mar 30.

Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.

Cancer Med 2022 Mar 28. Epub 2022 Mar 28.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Background: The progression rate from CIN1 to CIN3 is 9.0% and that for invasive cancer is 1.0%. Read More

J Matern Fetal Neonatal Med 2022 Mar 27:1-6. Epub 2022 Mar 27.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Objective: Pregnancy after conization is associated with a high risk of preterm delivery. However, because risk factors for preterm delivery after conization remain unknown, we conducted a multicenter observational study to investigate risk factors associated with preterm delivery.

Methods: We selected patients who had previously undergone conization and reviewed medical records from 18 hospitals in cooperation with Keio University School of Medicine between January 2013 and December 2019. Read More

J Obstet Gynaecol Res 2022 Mar 21. Epub 2022 Mar 21.

Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto-city, Kumamoto, Japan.

Objectives: To evaluate the oncologic and obstetric outcomes of cervical conization followed by pelvic lymphadenectomy, which is used as a fertility-sparing procedure, in reproductive-aged patients with early-stage cervical cancer.

Methods: We performed a retrospective study of patients with stage IA1-IB1 cervical cancer who underwent cervical conization followed by pelvic lymphadenectomy from 2011 to 2020 at Kumamoto University Hospital.

Results: In total, eight patients underwent conization followed by pelvic lymphadenectomy. Read More

Int J Womens Health 2022 8;14:345-351. Epub 2022 Mar 8.

Cervical Diseases Center, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People's Republic of China.

Septate uterus with duplicate cervices and double vagina is a rare Müllerian duct anomaly mostly found in labor or gynecological examination. We present a case of a 40-year-old asymptomatic parous patient diagnosed with double cervix and complete vaginal septum. She was admitted to hospital due to abnormal histopathology of suspicious cervical squamous papillary carcinoma post-salpingectomy. Read More

Front Med (Lausanne) 2022 28;9:807849. Epub 2022 Feb 28.

Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.

Introduction: Currently, the commonly used surgical methods for cervical lesions include loop electrosurgical excision procedure (LEEP) and cold knife conization (CKC). However, the positive rate of surgical margins after LEEP is relatively high, which leads to disease recurrence and places further demand on clinical treatment. This study investigated factors related to positive margins after LEEP and established a scoring system to enhance preoperative risk assessment and surgical selection. Read More

Rev Bras Ginecol Obstet 2022 Mar 11. Epub 2022 Mar 11.

Department of Gynecology and Obstetrics, Universidade Positivo, Curitiba, PR, Brazil.

Objective:  To evaluate the role of cervical cytology (Pap smear) in the diagnosis of cervical intraepithelial neoplasia 2 or greater (CIN2 + ), presented exclusively in the endocervical canal, the clinical-epidemiological characteristics of this lesion, the necessary length of canal to be removed to treat, and the rate of invasive lesion hidden in the endocervical canal.

Methods:  Cross-sectional study, by database analysis, of patients with abnormal cytology (high-grade squamous intraepithelial lesion [HSIL]), without visible colposcopy lesion, submitted to loop electrosurgical procedure (LEEP) to evaluate the association of cytology results with the histological product of the conization, to identify the epidemiological characteristics of endocervical lesion and clinical evolution, using a -value < 0.05 and 95% CI. Read More

PLoS One 2022 11;17(3):e0264821. Epub 2022 Mar 11.

Department of Surgical Oncology, Institut Curie, Saint-Cloud, France.

Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study.

Methods: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. Read More

J Midlife Health 2021 Oct-Dec;12(4):281-286. Epub 2022 Jan 20.

Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.

Aim: To evaluate the role of endocervicoscopy for the visualization of the T3 transformation zone (TZ) on colposcopy.

Materials And Methods: Forty patients with either abnormal Pap smear or positive VIA-VILI and T3 TZ on colposcopy were recruited from the colposcopy clinic and subjected to endocervicoscopy with a 4-mm office hysteroscope. The view of the endocervical canal was recorded before and after the application of 5% acetic acid and the squamocolumnar junction was identified in its entirety. Read More

Ann Diagn Pathol 2022 Jun 26;58:151929. Epub 2022 Feb 26.

Department of Gynecology, Clinical Hospital Complex of the Federal University of Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, Paraná 80060-900, Brazil.

Objectives: Cervical conization specimens with a negative result for high-grade lesion are not infrequent in clinical practice and there are no protocols to address this issue. The purpose of this manuscript is to analyze factors that affect the reliability on these situations and provide recommendations to guide the gynecologists on their practice.

Methods: We searched original articles on Pubmed/Medline database that analyzed negative cones using different combinations of descriptors. Read More

Asian Pac J Cancer Prev 2022 Feb 1;23(2):659-664. Epub 2022 Feb 1.

Department of Obstetrics and Gynecology, Faculty of Medicine, Srinakharinwirot University, Nakhon-Nayok, Thailand.

Objective: To determine the appropriate cone depth for treating high grade precancerous lesions to achieve negative pathological margins of cones from LEEPs. Other factors associated with positive pathological margin were also investigated.

Methods: A Retrospective study recruited 170 patients who received indications for LEEP during January 2015 to July 2020 were enrolled. Read More

J Health Econ Outcomes Res 2022 7;9(1):31-38. Epub 2022 Feb 7.

Center for Observational and Real-world Evidence, Merck Sharp & Dohme, Madrid, Spain.

Cervical cancer rates in North Africa have risen in the last 10 years, suggesting that this region might benefit from cervical cancer screening and HPV vaccination programs. To assess the potential benefits of cervical cancer screening and HPV vaccination in North African countries, country-specific data on the prevalence and burden of HPV-related conditions are needed. To describe the patterns and estimate the costs of management of cervical cancer, cervical intraepithelial neoplasia (CIN), and genital warts in Algeria. Read More

Arch Gynecol Obstet 2022 Feb 27. Epub 2022 Feb 27.

Department of Obstetrics and Gynecology, University of Campinas, Rua Vital Brasil, 80 Cidade Universitária, Campinas, CEPSão Paulo, 13083-888, Brazil.

Purpose: To describe the results of 610 patients who underwent LEEP and evaluate factors related to a negative margin.

Methods: A retrospective study of patients treated by LEEP at a colposcopy referral service in Campinas, Brazil, 2017-2019. Patients were referred to treat high-grade squamous intraepithelial lesion or adenocarcinoma in situ suspected by cytology and colposcopy (screen-and-treat) or by biopsy. Read More

Viruses 2022 01 25;14(2). Epub 2022 Jan 25.

Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing 100033, China.

In 2014 and 2021, two nucleic-acid vaccine candidates named MAV E2 and VGX-3100 completed phase III clinical trials in Mexico and U.S., respectively, for patients with human papillomavirus (HPV)-related, high-grade squamous intraepithelial lesions (HSIL). Read More

Vaccines (Basel) 2022 Feb 14;10(2). Epub 2022 Feb 14.

Gynecology Oncology Unit, Institute of Women's Health, San Carlos Clinical Hospital (IdISSC), Complutense University, 28040 Madrid, Spain.

Recent data have shown that the human papillomavirus (HPV) vaccine could impact on a decrease in high-grade cervical intraepithelial lesions (HSIL) in women who have undergone surgical treatment. This study aimed to evaluate the efficacy of human papilloma virus (HPV) vaccination against persistent/recurrent disease in patients undergoing conization for high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia-grade 2-3 (HSIL/CIN 2-3). From January 2009 to March 2019, 563 patients with HSIL/CIN 2-3 underwent conization. Read More

Medicine (Baltimore) 2022 Feb;101(8):e28911

Department of Obstetrics and Gynaecology, Konkuk University Hospital, Seoul, Korea.

Abstract: This study compared survival outcomes for patients with stage IB1 to IIA2 (International Federation of Gynecology and Obstetrics stage 2009) cervical cancer who underwent open radical hysterectomy (ORH) versus those who underwent minimally invasive radical hysterectomy (MIRH) using vaginal colpotomy (VC).Data for 550 patients who were diagnosed with cervical cancer at our institution during the period August 2005 to September 2018 was retrospectively reviewed. Of these, 116 patients who underwent radical hysterectomy (RH) were selected after applying the exclusion criteria. Read More

Int J Gynecol Cancer 2022 Apr 4;32(4):486-493. Epub 2022 Apr 4.

Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.

Objective: The objective of this systematic review was to assess the oncologic and fertility outcomes of patients with cervix-confined cancer >4 cm who underwent neo-adjuvant chemotherapy followed by fertility-sparing surgery.

Methods: This study was registered in PROSPERO (registration number CRD42021254816). PubMed/MEDLINE, ClinicalTrials, EMBASE, Cochrane Central Register of Controlled Trials, SCOPUS, and OVID databases were searched from inception to July 2021. Read More

Curr Oncol 2022 02 14;29(2):1093-1106. Epub 2022 Feb 14.

Gynecologic Oncology Division, L'Hotel-Dieu de Québec, CHU de Québec, Laval University, Quebec, QC G1V 0A6, Canada.

Cervical cancer is the most common gynecologic malignancy and the fourth most common cancer in women worldwide. Over the last two decades, minimally invasive surgery (MIS) emerged as the mainstay in the surgical management of cervical cancer, bringing advantages such as lower operative morbidity and shorter hospital stay compared to open surgery while maintaining comparable oncologic outcomes in numerous retrospective studies. However, in 2018, a prospective phase III randomized controlled trial, "Laparoscopic Approach to Carcinoma of the Cervix (LACC)", unexpectedly reported that MIS was associated with a statistically significant poorer overall survival and disease-free survival compared to open surgery in patients with early-stage cervical cancer. Read More