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    3584 results match your criteria Congestive Heart Failure and Pulmonary Edema

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    Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.
    ACS Med Chem Lett 2017 May 20;8(5):549-554. Epub 2017 Mar 20.
    GlaxoSmithKline, Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, King of Prussia, Pennsylvania 19406, United States.
    Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in the vascular endothelium in the lung and regulates the integrity of the alveolar septal barrier. Increased pulmonary vascular pressure evokes TRPV4-dependent pulmonary edema, and therefore, inhibition of TRPV4 represents a novel approach for the treatment of pulmonary edema associated with conditions such as congestive heart failure. Read More

    Central-acting therapeutics alleviate respiratory weakness caused by heart failure-induced ventilatory overdrive.
    Sci Transl Med 2017 May;9(390)
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
    Diaphragmatic weakness is a feature of heart failure (HF) associated with dyspnea and exertional fatigue. Most studies have focused on advanced stages of HF, leaving the cause unresolved. The long-standing theory is that pulmonary edema imposes a mechanical stress, resulting in diaphragmatic remodeling, but stable HF patients rarely exhibit pulmonary edema. Read More

    Percutaneous left atrial decompression in adults with refractory cardiogenic shock supported with veno-arterial extracorporeal membrane oxygenation.
    J Card Surg 2017 May 11. Epub 2017 May 11.
    Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario.
    Background And Aim Of The Study: Left ventricular (LV) distention, a recognized complication in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock, can lead to pulmonary edema, increased myocardial oxygen consumption, and LV thrombus formation. Atrial septostomy was examined as a management strategy for LV distension.

    Methods: Of 72 patients supported with VA-ECMO, seven patients underwent atrial septostomy through a trans-septal approach. Read More

    Atrial Septostomy for Left Atrial Decompression During Extracorporeal Membrane Oxygenation by Inoue Balloon Catheter.
    Circ J 2017 May 11. Epub 2017 May 11.
    Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital.
    Background: Refractory pulmonary edema is an infrequent but serious complication in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) for myocardial failure. Left atrial (LA) decompression in this setting is important. Although a few methods have been reported, the experience is mostly limited to children. Read More

    Left Atrial Size and Heart Failure Hospitalization in Patients with Diastolic Dysfunction and Preserved Ejection Fraction.
    J Cardiovasc Echogr 2017 Jan-Mar;27(1):1-6
    Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, FL, USA.
    Context: Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome associated with diastolic function abnormalities. It remains unclear which factors, if any, can predict the transition from asymptomatic diastolic dysfunction to an overt symptomatic phase.

    Materials And Methods: Patients hospitalized with suspected heart failure between January 2012 and November 2014 with a transthoracic echocardiogram demonstrating preserved systolic function were screened (n = 425). Read More

    Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry.
    Eur J Heart Fail 2017 Apr 30. Epub 2017 Apr 30.
    ANMCO Research Center, Florence, Italy.
    Aims: To identify differences in clinical epidemiology, in-hospital management and 1-year outcomes among patients hospitalized for acute heart failure (AHF) and enrolled in the European Society of Cardiology Heart Failure Long-Term (ESC-HF-LT) Registry, stratified by clinical profile at admission.

    Methods And Results: The ESC-HF-LT Registry is a prospective, observational study collecting hospitalization and 1-year follow-up data from 6629 AHF patients. Among AHF patients enrolled in the registry, 13. Read More

    Chronic Atrial Fibrillation Ablation with Harmonic Scalpel during Mitral Valve Surgery.
    Braz J Cardiovasc Surg 2017 Jan-Feb;32(1):22-28
    Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil and Universidade de Campinas (UNICAMP), Campinas, SP, Brazil.
    Objective: To evaluate surgical treatment of chronic atrial fibrillation with ultrasound in patients with mitral valve disease, considering preoperative clinical characteristics of patients undergoing surgical procedure and follow-up in the immediate postoperative period, in hospital and up to 60 months after discharge.

    Methods:: We studied 100 patients with chronic atrial fibrillation and mitral valve disease who underwent surgical treatment using ultrasound ablation. Patient data were reviewed by consulting the control reports, including signs and symptoms, underlying disease, functional class, hospital stay, surgical procedure time, ablation time, immediate complications, and complications at discharged and up to 60 months later. Read More

    Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction.
    Circ J 2017 Apr 18. Epub 2017 Apr 18.
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University.
    Background: Several studies have reported that colchicine attenuated the infarct size and inflammation in acute myocardial infarction (MI). However, the sustained benefit of colchicine administration on survival and cardiac function after MI is unknown. It was hypothesized that the short-term treatment with colchicine could improve survival and cardiac function during the recovery phase of MI. Read More

    Misses Opportunity: TOF Diagnoses in 4th Decade of Life.
    J La State Med Soc 2017 Mar-Apr;169(2):54. Epub 2017 Apr 15.
    Department of Internal Medicine, LSU Health, Baton Rouge, LA.
    Case: A 40 year old woman with a history of HIV, congestive heart failure secondary to an unknown congenital heart defect, and hypertension presented to our emergency department with worsening edema. On room air, oxygen saturation was 55 percent . On 5L of oxygen via nasal cannula, oxygen saturation was 88 percent . Read More

    Three's a Crowd - An Extremely Rare Case of Cor Triatriatum Dexter.
    J La State Med Soc 2017 Mar-Apr;169(2):50-51. Epub 2017 Apr 15.
    Department of Medicine, Leonard J. Chabert Medical Center in Houma, LA.
    Introduction: Cor triatriatum is a congenital cardiac anomaly in which the left (sinister) or right (dexter) atrium is divided into two compartments by residual embryonic tissue, resulting in a tri-atrial heart. As cor triatriatum dextrum can present clinically in various ways and have multiple associated cardiac anomalies, this report attempts to contribute to what is known about this exceedingly rare disorder.

    Case: A 40 year old Hispanic man with a medical history of gastritis presented with complaints of palpitations, dizziness and bilateral lower extremity edema. Read More

    Paediatric-onset coronary artery anomalies in pregnancy: a single-centre experience and systematic literature review.
    Cardiol Young 2017 Apr 17:1-9. Epub 2017 Apr 17.
    1Toronto Congenital Cardiac Centre for Adults,Toronto General Hospital,University of Toronto,Toronto,Ontario,Canada.
    Objectives: Individuals with childhood-onset coronary artery anomalies are at increased risk of lifelong complications. Although pregnancy is thought to confer additional risk, a few data are available regarding outcomes in this group of women. We sought to define outcomes of pregnancy in this unique population. Read More

    A rare complication of viper envenomation: cardiac failure. A case report.
    Med Sante Trop 2017 Feb;27(1):52-55
    Service de réanimation médicale, CHU Habib-Bourguiba 3029 Sfax Tunisie.
    Viper envenomation is common in North Africa. Cardiac complications are not common features of snakebites, the clinical picture of which is usually dominated by toxin-associated neurological, hematological, and vascular damage. There are rare reports of acute myocardial infarction and/or ischemia caused by snakebites, while myocarditis after envenomation has not yet been reported, to our knowledge. Read More

    Assessment of Lung Ultrasound B-Lines in Dogs with Different Stages of Chronic Valvular Heart Disease.
    J Vet Intern Med 2017 May 29;31(3):700-704. Epub 2017 Mar 29.
    Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
    Background: In dogs with chronic valvular heart disease (CVHD), early recognition of pulmonary edema (PE) is of paramount importance. Recent studies in dogs showed that lung ultrasound examination (LUS) is a useful technique to diagnose cardiogenic PE.

    Objectives: To describe LUS features in dogs with different stages of CVHD, and to determine its diagnostic accuracy in detecting PE using thoracic radiography as the reference standard. Read More

    J Zoo Wildl Med 2017 Mar;48(1):179-188
    Acute signs associated with cardiovascular disease occurred in three pregnant okapi ( Okapia johnstoni ) during early to midgestation and progressed to congestive heart failure. Congestive heart failure was diagnosed antemortem using echocardiography and plasma cardiac troponin levels. Clinical signs included decreased activity, hyporexia, tachypnea, dyspnea, flared nostrils, and productive coughing with copious amounts of foamy nasal discharge. Read More

    New pharmacological and technological management strategies in heart failure.
    Vasc Health Risk Manag 2017 21;13:111-121. Epub 2017 Mar 21.
    Division of Cardiovascular Medicine, Center for Advanced Heart Disease, Brigham and Women's Hospital, Boston, MA, USA.
    Heart failure is a complex clinical syndrome resulting from impairment of ventricular filling or ejection of blood associated with symptoms of dyspnea, fatigue, as well as peripheral and/or pulmonary edema. This syndrome is progressive and characterized by worsening quality of life despite escalating levels of care, affecting 5.7 million Americans with an annual cost of over ≥30 billion US dollars. Read More

    Atypical Complications of Graves' Disease: A Case Report and Literature Review.
    Case Rep Endocrinol 2017 28;2017:6087135. Epub 2017 Feb 28.
    Endocrine Department, Hamad Medical Corporation, Doha, P.O. Box 3050, Qatar.
    Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. Read More

    An unusual case of sudden unexpected death due to massive hemopericardium from primary mediastinal seminoma.
    Forensic Sci Int 2017 Jan 14;270:e1-e4. Epub 2016 Oct 14.
    Department of Pathology, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Rd., Sribhoom, Chiang Mai 50200, Thailand. Electronic address:
    It is well-known that cardiovascular disease is the most common cause of sudden unexpected death, especially in the young. However complete postmortem investigation performed by qualified forensic pathologists is crucial in establishing the exact cause and manner of death. Sudden death caused by a cardiac tamponade occurring secondarily to a primary mediastinal tumor is extremely unusual. Read More

    Renal Artery Stenosis: When to Revascularize in 2017.
    Curr Probl Cardiol 2017 Apr 20;42(4):110-135. Epub 2017 Jan 20.
    Atherosclerotic renal artery stenosis is the leading cause of secondary hypertension; it can also cause progressive renal insufficiency and cardiovascular complications such as refractory heart failure and flash pulmonary edema. Medical therapy including risk factor modification, renin-angiotensin-aldosterone system antagonists, lipid lowering agents, and antiplatelet therapy is the first line of treatment in all patients. Patients with uncontrolled renovascular hypertension despite optimal medical therapy, ischemic nephropathy, and cardiac destabilization syndromes who have severe renal artery stenosis are likely to benefit from renal artery revascularization. Read More

    Vasoproliferative process resembling pulmonary capillary hemangiomatosis in a cat.
    BMC Vet Res 2017 Mar 20;13(1):72. Epub 2017 Mar 20.
    University of Missouri Veterinary Health Center, Columbia, MO, USA.
    Background: Pulmonary capillary hemangiomatosis is a rare, vascular obstructive disorder that uniformly causes pulmonary arterial hypertension. Clinically, pulmonary capillary hemangiomatosis is indistinguishable from primary pulmonary arterial hypertension and histology is required for definitive diagnosis. The distinctive histologic feature of pulmonary capillary hemangiomatosis is non-malignant extensive proliferation of capillaries in the alveolar septae. Read More

    Airway inflammation and symptoms in children following liver and heart transplantation.
    Clin Transplant 2017 Mar 18. Epub 2017 Mar 18.
    Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, OH, USA.
    Objectives: To describe the upper airway endoscopic findings of children with upper airway symptoms after liver transplantation (LT) or heart transplantation (HT).

    Methods: Review of children undergoing airway endoscopy after LT or HT from 2011 to 2015 at a tertiary care pediatric hospital. Airway findings, biopsy results, immunosuppression, and Epstein-Barr virus (EBV) levels were recorded. Read More

    Remote Monitoring in Heart Failure: the Current State.
    Curr Treat Options Cardiovasc Med 2017 Mar;19(3):22
    Cardiology, Lancaster Heart and Vascular Institute, Lancaster General Hospital/Penn Medicine, Lancaster, PA, USA.
    Opinion Statement: The treatment of congestive heart failure is an expensive undertaking with much of this cost occurring as a result of hospitalization. It is not surprising that many remote monitoring strategies have been developed to help patients maintain clinical stability by avoiding congestion. Most of these have failed. Read More

    [Clinical Case of Severe Heart Failure Treatment, Produced due to the Development of Arrhythmogenic Cardiomyopathy in a Patient With Permanent Junctional Reciprocating Tachycardia (Coumels Tachycardia) With Additional Left Lateral Accessory Pathway].
    Kardiologiia 2016 Feb;56(2):91-96
    1Federal Research Clinical Center for specialized types of health care and medical technologies of Federal Biomedical Agency of Russia, Moscow, Russia; 2Institute of Postgraduate Education of Federal Biomedical Agency, Moscow, Russia; 3City hospital 4 of Vladimir, Vladimir region, Russia.
    Thirty two years old man had history of atrioventricular re-entry tachycardia (AVRT) with concealed left-lateral accessory pathway (AP), 3-5episodes per year, 30-40 minutes duration without hemodynamic compromise. Two years ago patient underwent ablation of concealed left lateral AP. After that tachycardia became malignant (high-frequent 150 beats-min, incessant (lasting up to 18 h/day), resistant to AAD, and led to development of tachycardia-induced cardiomyopathy (EF was 16%, and 2 episodes of pulmonary oedema). Read More

    Obstructed Infradiaphragmatic Total Anomalous Pulmonary Venous Return in a 13-Day-Old Infant Presenting Acutely to the Emergency Department: A Case Report.
    J Emerg Med 2017 Mar 9. Epub 2017 Mar 9.
    Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, Arizona; Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona.
    Background: Total anomalous pulmonary venous return (TAPVR) is an uncommon congenital heart defect. Obstructed forms are more severe, and typically present earlier in life, usually in the immediate newborn period, with symptoms of severe cyanosis and respiratory failure.

    Case Report: A 13-day-old boy presented to the emergency department (ED) with respiratory extremis. Read More

    Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial.
    Cardiovasc Drugs Ther 2017 Apr;31(2):209-213
    Departamento de Ciencias Médicas Básicas (Unidad de Fisiología), Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
    Purpose: Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug. The non-specific depression of the central nervous system is probably the most significant factor for the changes in hemodynamics in APE. Retrospective studies have shown both negative and neutral effects in patients with APE and therefore some authors have suggested benzodiazepines as an alternative treatment. Read More

    Revascularization of Atherosclerotic Renal Artery Stenosis for Chronic Heart Failure Versus Acute Pulmonary Oedema.
    Nephrology (Carlton) 2017 Feb 27. Epub 2017 Feb 27.
    Institute of Cardiovascular Sciences, University of Manchester, Manchester Academic Health Sciences Centre, UK.
    Aim: To determine whether the apparent benefit of revascularization of renal artery stenosis for "flash" pulmonary oedema extends to heart failure patients without a history of prior acute pulmonary oedema.

    Methods: A prospective study of patients with renal artery stenosis and heart failure at a single centre between 1(st) January 1995 and 31(st) December 2010. Patients were divided into those with and without previous acute pulmonary oedema / decompensation. Read More

    Clinical Presentation and Value of Echocardiography in the Diagnosis of Freestyle Aortic Bioprosthesis Leaflet Tears: A Retrospective Study.
    J Heart Valve Dis 2016 Sep;25(5):628-633
    Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec, Canada. Electronic correspondence:
    Background: The unique design of the Freestyle stentless aortic bioprosthesis has led to different mechanisms of failure, particularly leaflet tearing. The aim of this retrospective study was to review the clinical presentation and echocardiographic data of symptomatic patients with leaflet tears and significant aortic regurgitation (AR) following implantation of the Freestyle bioprosthesis.

    Methods: Between January 1993 and May 2011, a total of 430 consecutive patients was identified at the authors' institution who had undergone primary aortic valve replacement with a Freestyle stentless aortic bioprosthesis. Read More

    Pulmonary endarterectomy outputs in chronic thromboembolic pulmonary hypertension.
    Med Clin (Barc) 2017 Feb 20. Epub 2017 Feb 20.
    Unidad Multidisciplinar de Hipertensión Pulmonar, Servicio de Cirugía Cardiaca, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España.
    Background And Objective: Pulmonary thromboendarterectomy surgery is the treatment of choice for patients with chronic thromboembolic pulmonary hypertension; extremely high pulmonary vascular resistance constitutes a risk factor for hospital mortality. The objective of this study was to analyze the immediate and long-term results of the surgical treatment of chronic thromboembolic pulmonary hypertension in patients with very severe pulmonary hypertension.

    Material And Methods: Since February 1996, we performed 160 pulmonary thromboendarterectomies. Read More

    Identification, Associated Factors, and Prognosis of Symptom Clusters in Taiwanese Patients With Heart Failure.
    J Nurs Res 2017 Feb 17. Epub 2017 Feb 17.
    1RN, PhD, Associate Professor, Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC 2RN, PhD, FAAN, Professor, College of Nursing, University of Kentucky, Lexington, USA 3RN, DNSc, Chair Professor, Department of Nursing, Asia University, Taichung, Taiwan, ROC.
    Background: Patients with heart failure (HF) have multiple distressing symptoms that are associated with poor outcomes. These symptoms do not occur in isolation from each other but likely occur as discrete clusters that may prove helpful to clinicians trying to counsel patients about symptom monitoring and management. Defining common symptom clusters and determining the associations between symptom clusters and outcomes may improve patient management. Read More

    Hydrogen Sulfide Reduces Recruitment of CD11b(+)Gr-1(+) Cells in Mice With Myocardial Infarction.
    Cell Transplant 2017 May 9;26(5):753-764. Epub 2017 Feb 9.
    The present study aimed to elucidate the mechanisms by which hydrogen sulfide (H2S) attenuates left ventricular remodeling after myocardial infarction (MI). MI was created in mice by left coronary artery ligation. One group of mice received injections of the H2S donor sodium hydrosulfide (NaHS) immediately before and 1 h after ligation, while the control group received saline alone. Read More

    Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure - New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients.
    Circ J 2017 Apr 28;81(5):755-758. Epub 2017 Jan 28.
    Department of Cardiovascular Medicine, Yao Municipal Hospital.
    Background: The mechanisms of heart failure with preserved ejection fraction (HFpEF) need to be clarified immediately.Methods and Results:We examined diastolic function relative to arterial elasticity among hypertensive patients with preserved EF. Diastolic elastance (EdI)/effective arterial elastance (EaI), EdI/EaI=E/e'/(0. Read More

    Respiratory Muscle Training Improves Chemoreflex Response, Heart Rate Variability, and Respiratory Mechanics in Rats With Heart Failure.
    Can J Cardiol 2017 Apr 11;33(4):508-514. Epub 2016 Nov 11.
    Post Graduation Program in Health Sciences, Laboratory of Experimental Physiology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Post Graduation Program in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:
    Background: The aim of the present report was to evaluate respiratory muscle training (RMT) effects on hemodynamic function, chemoreflex response, heart rate variability, and respiratory mechanics in rats with heart failure (HF rats).

    Methods: Wistar rats were divided into 4 groups: sedentary-sham (Sed-Sham, n = 8), respiratory muscle trained-sham (RMT-Sham, n = 8), sedentary-HF (Sed-HF, n = 8) and respiratory muscle trained-HF (RMT-HF, n = 8). Animals were submitted to an RMT protocol performed 30 minutes per day, 5 days per week for 6 weeks, whereas the sedentary animals did not exercise. Read More

    Who Needs Longer Tolvaptan Treatment?
    Int Heart J 2017 Feb 20;58(1):30-35. Epub 2017 Jan 20.
    Second Department of Internal Medicine, University of Toyama.
    The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and longer treated group (15DL). The results showed that the patients in the 15DL group had low cardiac output with intensive diuretic administration (ie, diuretic resistance). Read More

    Acute kidney injury as an independent risk factor for unplanned 90-day hospital readmissions.
    BMC Nephrol 2017 Jan 6;18(1). Epub 2017 Jan 6.
    University of Aberdeen, Institute of Applied Health Sciences, Aberdeen, UK.
    Background: Reducing readmissions is an international priority in healthcare. Acute kidney injury (AKI) is common, serious and also a global concern. This analysis evaluates AKI as a candidate risk factor for unplanned readmissions and determines the reasons for readmissions. Read More

    A retrospective study of degenerative mitral valve disease in small-breed dogs: Survival and prognostic variables.
    J Vet Sci 2017 Jan 4. Epub 2017 Jan 4.
    Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
    Small-breed (n= 168 dogs; weight < 15 kg) diagnosed with MMVD based on a routine clinical examination, radiology, an electrocardiogram, and echocardiography at the Seoul National University Veterinary Medical Teaching Hospital were included. The survival periods were ascertained and a significant difference was observed in the survival rates between the International Small Animal Cardiac Health Council classes. The mean follow-up period was 14. Read More

    Sudden Death in a Male Infant Due to Histiocytoid Cardiomyopathy: An Autopsy Case and Review of the Literature.
    Am J Forensic Med Pathol 2017 Mar;38(1):32-34
    From the Department of Pathology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
    Histiocytoid cardiomyopathy (HC) is a very rare cardiac disorder that mainly affects female infants younger than 2 years. It may manifest as ventricular tachycardia or dilated cardiomyopathy and frequently causes sudden death. The most common grossly change is multifocal uneven thickening of the endocardium, presenting a yellowish color, with some area forming nodular appearance, and histologically featured by scattered clusters of histiocytoid myocytes under the endocardium. Read More

    Visceral and tissular reactivity in acute heart failure due to supraventricular tachyarrhythmia in a young patient.
    Rom J Morphol Embryol 2016 ;57(3):1099-1105
    Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Observation of major pathological alterations in a young person involves etiological and clinical justifications, in order to properly assess, treat and control these conditions. The aim of this paper is to present severe, acute pathological lesions, installed in a young person, secondary to hypodiastolic heart failure, due to persistent supraventricular tachyarrhythmia, triggered by a post-traumatic external stimulus, with complete remission post-electrical conversion. Pathological and clinical modification are revealed, in a young person, shortly after a minor thoracic trauma, in the absence of traumatic injury but with high-frequency palpitations onset and progressive installation of vascular, visceral and interstitial stasis modifications, as well as of vascular and tissular hypoperfusion with reactive vasoconstriction. Read More

    Pulmonary Complications After Open Abdominal Aortic Surgery: A Systematic Review and Meta-Analysis.
    J Cardiothorac Vasc Anesth 2017 Apr 1;31(2):562-568. Epub 2016 Oct 1.
    Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina, Milan, Italy.
    Objectives: Postoperative pulmonary complications (PPC) are among the most common complications after noncardiac surgery. Men, smokers, and elderly patients with chronic obstructive pulmonary disease or heart failure are more likely to experience PPC. The majority of patients undergoing vascular surgery belong in these categories and are at higher risk of developing PPC. Read More

    [Patient-related independent clinical risk factors for early complications following interventional pulmonology procedures].
    Beijing Da Xue Xue Bao 2016 Dec;48(6):1006-1011
    Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
    Objective: To investigate the early complication rate and identify patient-related independent clinical risk factors for early complications in patients following interventional pulmonology procedures.

    Methods: In the period from December 2014 to December 2015, sufficient data of Peking University First Hospital Respiratory and Critical Care Medicine Department for analysis were identified in 218 subjects. Interventional pulmonology procedures were performed in all the patients. Read More

    Echocardiography findings in a case with Ballantyne syndrome.
    J Obstet Gynaecol Res 2017 Feb 17;43(2):387-391. Epub 2016 Dec 17.
    Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Marked fluid retention occurs in Ballantyne syndrome, but few reports are available on changes in cardiac morphology in this syndrome. A woman with generalized edema, dyspnea, fetal hydrops (skin edema and ascites), thickened placenta, and elevated plasma B-type natriuretic peptide level (344 pg/mL) was admitted to our hospital at gestational week (GW) 20(+3) . Blood pressure remained within the normal range. Read More

    The importance of proteinuria and prior cardiovascular disease in all major clinical outcomes of atherosclerotic renovascular disease - a single-center observational study.
    BMC Nephrol 2016 Dec 7;17(1):198. Epub 2016 Dec 7.
    Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, M6 8HD, United Kingdom.
    Background: Identification of patients at risk of developing adverse events would enable aggressive medical therapy and possibly targeted revascularization. The aim of this study is to characterize the determinants of long-term outcomes in atherosclerotic renovascular disease (ARVD).

    Methods: Patients with a radiological diagnosis of ARVD were recruited into this single-center prospective cohort study between 1986 and 2014. Read More

    Association of Biomarkers with Serious Cardiac Adverse Events during Abiraterone Acetate Treatment in Castration Resistant Prostate Cancer.
    Transl Oncol 2016 Dec;9(6):600-605
    Units of Medical Oncology, E.O. Ospedali Galliera, Genova, Italy.
    Background: Abiraterone acetate is an effective drug for castration-resistant prostate cancer, but cardiac serious adverse events (SAEs) may occur. We studied their association with N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T (TnT) during abiraterone therapy.

    Patients And Methods: In a single institution, 17 patients were treated with abiraterone acetate 1 g daily with concomitant prednisone and then switched to dexametasone plus canrenone. Read More

    Pharmacokinetic study of furosemide incorporated PLGA microspheres after oral administration to rat.
    Iran J Basic Med Sci 2016 Oct;19(10):1049-1055
    Department of Pharmacology and Toxicology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah.
    Objectives: The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. The comparatively poor and inconstant BA of furosemide, which occurs site-specifically in the stomach and upper small intestine, has been ascribed to the poor dissolution of furosemide.

    Materials And Methods: In attempt to enhance the drug BA, poly (dl-lactic-co-glycolic acid) (PLGA) microspheres of furosemide were obtained using solvent-evaporation method and the carrier characteristics were investigated subsequently. Read More

    Effect of β2-adrenergic receptor stimulation on lung fluid in stable heart failure patients.
    J Heart Lung Transplant 2017 Apr 2;36(4):418-426. Epub 2016 Oct 2.
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    Background: The purpose of this study was to determine: (1) whether stable heart failure patients with reduced ejection fraction (HFrEF) have elevated extravascular lung water (EVLW) when compared with healthy control subjects; and (2) the effect of acute β2-adrenergic receptor (β2AR) agonist inhalation on lung fluid balance.

    Methods: Twenty-two stable HFrEF patients and 18 age- and gender-matched healthy subjects were studied. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), pulmonary capillary blood volume (Vc) (via re-breathe) and lung tissue volume (Vtis) (via computed tomography) were assessed before and within 30 minutes after administration of nebulized albuterol. Read More

    Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal.
    Crit Care 2016 Nov 12;20(1):369. Epub 2016 Nov 12.
    Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
    Background: Weaning-induced pulmonary oedema (WiPO) is a well-recognised cause of failure of weaning from mechanical ventilation, but its incidence and risk factors have not been reliably described. We wanted to determine the incidence and risk factors in a population of critically ill patients. In addition, we wanted to describe the effects of diuretics when they are administered in this context. Read More

    Identification of volume overload hospitalizations among hemodialysis patients using administrative claims: a validation study.
    BMC Nephrol 2016 Nov 11;17(1):173. Epub 2016 Nov 11.
    Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina Kidney Center, UNC School of Medicine, 7024 Burnett-Womack CB #7155, Chapel Hill, NC, 27599-7155, USA.
    Background: High rates of volume overload hospitalizations may indicate inadequate dialysis facility fluid management. Administrative claims databases are often used to study such outcomes, but these data are generated for billing purposes and may not capture clinical nuance. It is unknown if volume overload admissions can be correctly identified in administrative data and if a single claims-based definition for volume overload can be used across epidemiologic surveillance studies, observational studies of exposure-outcome associations and quality assessments. Read More

    Delayed High Output Heart Failure due to Arteriovenous Fistula Complicated with Herniated Disc Surgery.
    J Korean Med Sci 2016 Dec;31(12):2051-2053
    Department of Internal Medicine, Weiss Memorial Hospital, Chicago, IL, USA.
    A 36-year-old male presented with progressive exertional dyspnea over months. Physical examination showed jugular venous distension, lung crecipitations, femoral bruit and pitting pedal edema. Echocardiogram showed a dilated right ventricle with severe pulmonary hypertension and a non collapsing inferior vena cava (IVC). Read More

    Isolated Left Ventricular Apical Hypoplasia: Reporting a Case With Mild Manifestations and Different Echocardiography Features.
    Iran Red Crescent Med J 2016 Aug 16;18(8):e26065. Epub 2016 Jul 16.
    Isfahan University of Medical Sciences, Isfahan, IR Iran.
    Introduction: Isolated left ventricular apical hypoplasia is an unusual type of cardiomyopathy that presents with different clinical manifestations according to the age of the disease, ranging from no symptoms in children to congestive heart failure, pulmonary edema, or even malignant tachycardia in adults. To our knowledge, only a few cases of isolated left ventricular apical hypoplasia have been reported in Asian adults.

    Case Presentation: Herein, we described an adult case of isolated left ventricular apical hypoplasia referred to our heart center in Isfahan, Iran in 2015 with a complaint of mild dyspnea with the absence of obvious fatty tissue in the heart's apex and an absence of any shunt, which are common findings in patients with this phenomenon. Read More

    ECG Case of the Month: Heart Failure in a Man from Chile.
    J La State Med Soc 2016 Sep-Oct;168(5):180-181. Epub 2016 Oct 15.
    Department of Medicine at Louisiana State University Health Sciences Center in New Orleans, LA.
    A 49-year-old man visiting New Orleans from Chile comes to the hospital complaining of exertional dyspnea for 2 months with the more recent onset of ankle edema. He is a slender man with a blood pressure of 91/60 mmHg, crackles at both lung bases, and markedly distended neck veins. His cardiac rhythm is irregular. Read More

    In vitro performance investigation of SynCardia™ Freedom® driver via patient simulator mock loop.
    Int J Artif Organs 2016 Nov 15;39(10):502-508. Epub 2016 Oct 15.
    Cardiovascular Fluid Dynamics Laboratory HER, Department of Civil, Environmental and Architectural Engineering - DICEA, University of Padua, Padua - Italy.
    Purpose: The gold standard therapy for patients with advanced heart failure is heart transplant. The gap between donors and patients in waiting lists promoted the development of circulatory support devices, such as the total artificial heart (TAH). Focusing on in vitro tests performed with CardioWest™ TAH (CW) driven by the SynCardia Freedom® portable driver (FD) the present study goals are: i) prove the reliability of a hydraulic circuit used as patient simulator to replicate a quasi-physiological scenario for various hydrodynamic conditions, ii) investigate the hydrodynamic performance of the CW FD, iii) help clinicians in possible interpretation of clinical cases outcomes. Read More

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