3,835 results match your criteria Congestive Heart Failure and Pulmonary Edema


When a Diuretic Causes Pulmonary Oedema.

Eur J Case Rep Intern Med 2018 26;5(6):000864. Epub 2018 Jun 26.

High Dependency Unit, San Giovanni Bosco Hospital, Torino, Italy.

Background: Hydrochlorothiazide (HCTZ) is one of the most popular drugs for the treatment of hypertension and heart failure. Most of its side effects are harmless and predictable, but some studies report a few life-threatening reactions to this drug, one of the most dangerous being acute pulmonary oedema.

Case Report: A 73-year-old woman was admitted to the Emergency Department with acute respiratory failure due to pulmonary oedema. Read More

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http://dx.doi.org/10.12890/2018_000864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346883PMC

Fetomaternal Outcome in Eclampsia in Relationship with Gravidity.

Mymensingh Med J 2019 Jan;28(1):44-48

Dr Anonya Talukder, Junior Consultant, Department of Obs. and Gynae, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

Eclampsia is a well-recognized major cause of maternal and perinatal morbidity and mortality. Patient's age, occupational status, socioeconomic status, educational status, regular ANC (antenatal care) and gravidity may affect the outcome of mother and foetus. The purpose of this study is to see the fetomaternal outcome in eclampsia in relationship with gravidity. Read More

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January 2019

Gestational Weight Gain and Severe Maternal Morbidity at Delivery Hospitalization.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; the Department of Reproductive Sciences, Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut; and the New York City Department of Health and Mental Hygiene, New York, New York.

Objective: To examine whether women who varied from recommended gestational weight gain guidelines by the Institute of Medicine (IOM, now known as the National Academy of Medicine) were at increased risk of severe maternal morbidity during delivery hospitalization compared with those whose weight gain remained within guidelines.

Methods: We conducted a retrospective cohort study using linked 2008-2012 New York City discharge and birth certificate data sets. Cases of severe maternal morbidity were identified using International Classification of Diseases, 9th Revision, Clinical Modification codes based on the Centers for Disease Control and Prevention criteria, which consists of 21 indicators of possible life-threatening diagnoses, life-saving procedures, or death. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003114DOI Listing
February 2019
2 Reads

A mouse model of heart failure exhibiting pulmonary edema and pleural effusion: Useful for testing new drugs.

J Pharmacol Toxicol Methods 2019 Feb 6;96:78-86. Epub 2019 Feb 6.

Cardiovascular & Fibrosis Discovery Biology, Research & Development, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA. Electronic address:

Introduction: Mouse models of chronic heart failure (HF) have been widely used in HF research. However, the current HF models most often use the C57BL/6 mouse strain and do not show the clinically relevant characteristics of pulmonary congestion. In this study, we developed a robust mouse model of HF in the BALB/c mouse strain, exhibiting pulmonary edema and pleural effusion, and we validated the model using the standard pharmacological therapies in patients with chronic HF and reduced ejection fraction (HFrEF) or acute decompensated HF. Read More

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http://dx.doi.org/10.1016/j.vascn.2019.02.001DOI Listing
February 2019
1 Read

Accuracy of risk prediction scores in pregnant women with congenital heart disease.

Congenit Heart Dis 2019 Feb 6. Epub 2019 Feb 6.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine Philadelphia, Pennsylvania.

Objective: To assess performance of risk stratification schemes in predicting adverse cardiac outcomes in pregnant women with congenital heart disease (CHD) and to compare these schemes to clinical factors alone.

Design: Single-center retrospective study.

Setting: Tertiary care academic hospital. Read More

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http://dx.doi.org/10.1111/chd.12750DOI Listing
February 2019
2 Reads

Beneficial Effects of Imatinib in a Patient with Suspected Pulmonary Veno-Occlusive Disease.

Tohoku J Exp Med 2019 02;247(2):69-73

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH). The prognosis of PVOD patients remains poor, since no effective medical therapy is yet available. Imatinib is a tyrosine kinase inhibitor specific for platelet-derived growth factor receptor and is expected as a treatment option for pulmonary arterial hypertension (PAH). Read More

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http://dx.doi.org/10.1620/tjem.247.69DOI Listing
February 2019
1 Read

Major Cardiac Events in Patients Admitted to Intensive Care After Vascular Noncardiac Surgery: A Retrospective Cohort.

Semin Cardiothorac Vasc Anesth 2019 Jan 25:1089253218825442. Epub 2019 Jan 25.

1 São João Hospital Centre, Porto, Portugal.

Introduction: Patients proposed to vascular noncardiac surgery (VS) have several comorbidities associated with major adverse cardiac events (MACE). We evaluated incidence, predictors, and outcomes, and compared different scores to predict MACE after VS.

Methods: We included all patients admitted from 2006 to 2013. Read More

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http://dx.doi.org/10.1177/1089253218825442DOI Listing
January 2019
2 Reads

Treatment of Hypertensive Cardiogenic Edema with Intravenous High-Dose Nitroglycerin in a Patient Presenting with Signs of Respiratory Failure: A Case Report and Review of the Literature.

Am J Case Rep 2019 Jan 21;20:83-90. Epub 2019 Jan 21.

Department of Internal Medicine, San Juan City Hospital, San Juan, Puerto Rico.

BACKGROUND Pulmonary edema is the accumulation of fluid in the lung secondary to increased hydrostatic pressure. Hypertensive cardiogenic pulmonary edema presents with a sudden onset of severe dyspnea, tachycardia, and tachypnea, and can occur when the systolic blood pressure exceeds 160 mmHg in association with acute decompensated congestive cardiac failure (CCF). A case is presented of hypertensive cardiogenic pulmonary edema treated with high-dose nitroglycerin and includes a review of the literature. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913250
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http://dx.doi.org/10.12659/AJCR.913250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350673PMC
January 2019
5 Reads

Coughing in dogs: what is the evidence for and against a cardiac cough?

Authors:
L Ferasin C Linney

J Small Anim Pract 2019 Jan 16. Epub 2019 Jan 16.

Willows Veterinary Referral Service, Solihull, West Midlands B90 4NH, UK.

Cough has been historically reported as a major clinical sign of cardiogenic pulmonary oedema in dogs. However, recent evidence appears to contradict the traditional dogmatic approach that linked cough to congestive heart failure in dogs. Here we use a question-based format to introduce and discuss the modern evidence regarding "cardiac cough" and the interpretation of this important but often misleading clinical sign. Read More

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http://dx.doi.org/10.1111/jsap.12976DOI Listing
January 2019
2 Reads

Safe Exchange of a Transfemoral Impella Pump.

Cardiovasc Revasc Med 2018 Dec 19. Epub 2018 Dec 19.

Cardiac Arrest Center, Advanced Heart Failure Unit, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

Mechanical circulatory support with the Impella pump is established in many centers treating patients with cardiogenic shock. While Impella pumps usually run very stable, it may still be possible that one needs to remove the pump for using the same vascular access for different reasons. Unfortunately, until now it had been nearly impossible to remove the pump while preserving arterial access without severe bleeding. Read More

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http://dx.doi.org/10.1016/j.carrev.2018.12.006DOI Listing
December 2018
3 Reads

Takayasu arteritis: differential diagnosis in a teenager with severe acute kidney injury - a case report.

J Bras Nefrol 2019 Jan 10. Epub 2019 Jan 10.

Hospital Geral de Fortaleza, Departamento de Nefrologia, Fortaleza, CE, Brasil.

Takayasu arteritis (TA) is a chronic granulomatous inflammatory condition of unknown cause that involves large vessels - particularly the aorta and its branches - such as the carotid, coronary, pulmonary, and renal arteries. The left subclavian artery is the most frequently involved vessel. Stenosis of the renal artery has been reported in 23-31% of the cases and may result in malignant hypertension, ischemic renal disease, decompensated heart failure, and premature death. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0174DOI Listing
January 2019
2 Reads

Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.

Am J Cardiovasc Drugs 2019 Jan 14. Epub 2019 Jan 14.

GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke's Hospital, Cambridge, UK.

Introduction And Objective: Pulmonary capillary endothelial transient receptor potential vanilloid 4 (TRPV4) channel plays a critical role in mediating the development of cardiogenic pulmonary edema. GSK2798745 is a first-in-class, highly potent, selective, orally active TRPV4 channel blocker being evaluated in a first-time-in-humans study (NCT02119260).

Methods: GSK2798745 was administered in a randomized, placebo-controlled study design to healthy volunteers in three separate cohorts as single escalating doses, with and without food, and as once-daily repeat doses for up to 14 days, respectively. Read More

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http://dx.doi.org/10.1007/s40256-018-00320-6DOI Listing
January 2019
1 Read

A real life evaluation of non invasive ventilation in acute cardiogenic pulmonary edema: a multicenter, perspective, observational study for the ACPE SIMEU study group.

BMC Emerg Med 2018 Dec 29;18(1):61. Epub 2018 Dec 29.

Emergency Medicine Department, ASST Papa Giovanni XIII, Bergamo, Italy.

Background: During the past three decades conflicting evidences have been published on the use of non-invasive ventilation (NIV) in patients with acute cardiogenic pulmonary edema (ACPE). The aim of this study is to describe the management of acute respiratory failure (ARF) due to ACPE in twelve Italian emergency departments (EDs). We evaluated prevalence, characteristics and outcomes of ACPE patients treated with oxygen therapy, continuous positive airway pressure (CPAP) or Bi-level positive airway pressure (BiPAP) on admission to the EDs. Read More

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http://dx.doi.org/10.1186/s12873-018-0216-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310941PMC
December 2018
2 Reads

Adrenomedullin in heart failure: pathophysiology and therapeutic application.

Eur J Heart Fail 2019 Feb 28;21(2):163-171. Epub 2018 Dec 28.

Division of Cardiology, Stony Brook University, Stony Brook, NY, USA.

Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma. It is synthesized by endothelial and vascular smooth muscle cells and diffuses freely between blood and interstitium. Excretion of ADM is stimulated by volume overload to maintain endothelial barrier function. Read More

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http://dx.doi.org/10.1002/ejhf.1366DOI Listing
February 2019
2 Reads

Downregulated microRNA-27b attenuates lipopolysaccharide-induced acute lung injury via activation of NF-E2-related factor 2 and inhibition of nuclear factor κB signaling pathway.

J Cell Physiol 2019 May 24;234(5):6023-6032. Epub 2018 Dec 24.

Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Acute lung injury (ALI) is a life-threatening, diffuse heterogeneous lung injury characterized by acute onset, pulmonary edema, and respiratory failure. Lipopolysaccharide (LPS) is a leading cause for ALI and when administered to a mouse it induces a lung phenotype exhibiting some of the clinical characteristics of human ALI. This study focused on investigating whether microRNA-27b (miR-27b) affects ALI in a mouse model established by LPS-induction and to further explore the underlying mechanism. Read More

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http://dx.doi.org/10.1002/jcp.27187DOI Listing
May 2019
4 Reads

The Use of Bromocriptine for Peripartum Cardiomyopathy after Twin Delivery via Oocyte Donation.

Intern Med 2019 Feb 18;58(4):541-544. Epub 2018 Dec 18.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Japan.

Peripartum cardiomyopathy (PPCM) is rare but life-threatening. We herein report the case of a 48-year-old woman with PPCM after oocyte donation and delivery of twins. Two weeks after delivery, she suffered from severe symptoms of heart failure [orthopnea, New York Heart Association (NYHA) class IV, pulmonary edema and a reduced left ventricular ejection fraction of 18%]. Read More

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http://dx.doi.org/10.2169/internalmedicine.1537-18DOI Listing
February 2019
1 Read

Thrombo-embolic complications in takotsubo syndrome: Review and demonstration of an illustrative case.

Clin Cardiol 2019 Feb 3;42(2):312-319. Epub 2019 Jan 3.

Coronary Artery Disease Area, Heart and Vascular Theme, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Thrombo-embolism is one of the serious complications of takotsubo syndrome (TS) in addition to heart failure, pulmonary edema, cardiogenic shock, cardiac arrest, life-threatening arrhythmias, left ventricular outlet tract obstruction, mitral regurgitation, cardiac rupture, and death. The most common cardio-embolic events in TS are cerebral, renal, and peripheral embolism. Approximately, one-third of patients with left ventricular thrombus (LVT) in TS develop embolic complications. Read More

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http://dx.doi.org/10.1002/clc.23137DOI Listing
February 2019
4 Reads

Pulmonary Production of Soluble ST2 in Heart Failure.

Circ Heart Fail 2018 Dec;11(12):e005488

IMIB-Arrixaca, University of Murcia, Spain (M.T.P.-M., M.C.A.-L., C.M.M., A.L.).

Background: Serum concentrations of ST2 (interleukin-1 receptor-like 1) represent a meaningful prognostic marker in cardiac diseases. Production of soluble ST2 (sST2) may be partially extracardiac. Identification of sST2 sources is relevant to design strategies for modulating its signaling. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005488DOI Listing
December 2018
5 Reads

Double Valve Failure Due to Perceval Sutureless Aortic Valve Migration.

J Heart Valve Dis 2018 Jan;27(1):124-126

Cardiac Surgery Unit, Heart Center, Grande Ospedale Metropolitano 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy.

A 76-year-old woman was admitted to the authors' hospital with pulmonary edema five months after the successful implantation of a Perceval sutureless aortic valve (Sorin Group Srl, Saluggia, Italy). Both echocardiography and computed tomography scanning demonstrated migration of the aortic valve into the left ventricle, causing severe aortic and mitral (secondary) insufficiency. Following heart team discussions, the sutureless valve was replaced with a standard bioprosthesis (Perimount, Magna Ease; Edwards Lifesciences, Irvine, California, USA) with spontaneous restoration of native mitral valve competence. Read More

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January 2018
2 Reads

Resistant Hypertension From Renal Artery Stenosis Leading to Heart Failure With Preserved Ejection Fraction.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618816501. Epub 2018 Dec 7.

University of Alberta, Edmonton, Alberta, Canada.

Resistant hypertension remains an important cause of heart failure. In this article, we describe a case of resistant hypertension in a 63-year-old woman leading to heart failure and marked morbidity. Her clinical course was characterized by chronic pleural effusions and recurrent hospitalizations with respiratory failure and flash pulmonary edema associated with heart failure with preserved ejection fraction. Read More

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http://dx.doi.org/10.1177/2324709618816501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291873PMC
December 2018
1 Read

Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis.

Anesthesiology 2019 Jan;130(1):83-91

From the Departments of Anesthesiology and Intensive Care (A.D., M.M., B.P.) Emergency Medicine (H.H.), Medical University of Vienna, Vienna, Austria the Department of Anesthesiology, Washington University, St. Louis, Missouri (P.N.) Department of Public Health Sciences, University of Chicago, University of Chicago, Illinois (T.K.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Cardiac events after electroconvulsive therapy have been reported sporadically, but a systematic assessment of the risk is missing. The goal of this study was to obtain a robust estimate of the incidence of major adverse cardiac events in adult patients undergoing electroconvulsive therapy.

Methods: Systematic review and meta-analysis of studies that investigated electroconvulsive therapy and reported major adverse cardiac events and/or mortality. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300062PMC
January 2019
1 Read

Preliminary evidence that hydrostatic edema may contribute to the formation of diffuse alveolar damage in a Holstein calf model.

F1000Res 2018 26;7:374. Epub 2018 Mar 26.

Departments of Animal and Food Sciences, College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX, 79409, USA.

Two notable findings of clinically healthy feedlot cattle suggest they may have pulmonary hydrostatic edema during the finishing phase of production: increased pulmonary arterial wedge pressures and pulmonary venous hypertrophy. The goal of this study was to determine if increased pulmonary arterial wedge pressure (PAWP) in a Holstein calf could lead to diffuse alveolar damage consistent with the early, exudative phase of acute interstitial pneumonia of feedlot cattle. Six male Holstein dairy calves were given daily subcutaneous injections of the nonspecific ß-adrenergic agonist isoprenaline (10 mg/kg/d), to induce left ventricular diastolic dysfunction, or sterile water for 14 days. Read More

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http://dx.doi.org/10.12688/f1000research.14153.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263485PMC
March 2018
3 Reads

Amyloid Cardiomyopathy in the Emergency Department.

J Emerg Med 2019 Feb 13;56(2):205-209. Epub 2018 Dec 13.

Department of Emergency Medicine, Mount Sinai Medical Center, Miami Beach, Florida; Emergency Department Ultrasonography, Mount Sinai Medical Center, Miami Beach, Florida.

Background: Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins.

Case Report: We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183104
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http://dx.doi.org/10.1016/j.jemermed.2018.10.023DOI Listing
February 2019
18 Reads

Right ventricular failure following placement of a percutaneous left ventricular assist device.

Heart Lung 2018 Dec 11. Epub 2018 Dec 11.

Center for Comprehensive Cardiovascular care, St Louis University, 3635 Vista Avenue, FDT 13th Floor, Cardiology, St Louis, MO, United States.

Right ventricular (RV) dysfunction following surgical implantation of a left ventricular assist device (LVAD) is a well-documented phenomenon, and it is associated with poor outcomes. We are reporting a 25-year-old male patient who presented to the hospital with flu-like symptoms, hypotension and acute hypoxic respiratory failure. The patient's Laboratory data was significant for elevated troponin, and his Chest X-ray showed acute pulmonary edema. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2018.12.002DOI Listing
December 2018
3 Reads
1.320 Impact Factor

Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction.

Eur Heart J 2018 Dec 12. Epub 2018 Dec 12.

The Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, USA.

Aims: Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and function within the same patient.

Methods And Results: Patients with unequivocal HFpEF defined by either invasive haemodynamics or hospitalization for pulmonary oedema (n = 271) underwent serial echocardiographic evaluations >6 months apart. Clinical, structural, functional, and haemodynamic characteristics were examined. Read More

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http://dx.doi.org/10.1093/eurheartj/ehy809DOI Listing
December 2018
3 Reads

Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.

Am J Case Rep 2018 Dec 6;19:1445-1448. Epub 2018 Dec 6.

Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

BACKGROUND Levo-transposition of the great arteries (L-TGA) is a rare form of congenital heart disease that may go unrecognized until adulthood. Parturient women with L-TGA have a high likelihood of developing acute pulmonary edema and cardiac dysrhythmias during the peri-partum period. CASE REPORT We present the case of a 32-year-old primigravida patient with previously unknown diagnosis of L-TGA, presenting with preeclampsia, whose peri-partum course was complicated by the development of acute pulmonary edema, complete heart block, and acute hypoxic respiratory failure. Read More

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http://dx.doi.org/10.12659/AJCR.912168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293864PMC
December 2018
2 Reads

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4) with In Vivo Activity in a Pulmonary Edema Model.

J Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Pulmonary edema is a common ailment of heart failure patients and has remained an unmet medical need due to dose-limiting side effects associated with current treatments. Preclinical studies in rodents have suggested that inhibition of TRPV4 cation channels may offer an alternative - and potentially superior - therapy. Efforts directed toward small molecule antagonists of the TRPV4 receptor have led to the discovery of a novel sulfone pyrrolidine sulfonamide chemotype exemplified by lead compound 6. Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01344
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http://dx.doi.org/10.1021/acs.jmedchem.8b01344DOI Listing
November 2018
10 Reads

Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways.

Biosci Trends 2018 ;12(5):491-501

Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Chronic heart failure (CHF) leads to pulmonary structural remodeling, which may be a key factor for poor clinical outcomes in patients with end-stage heart failure, and few effective therapeutic options are presently available. The aim of the current study was to explore the mechanism of action and pulmonary-protective effects of treatment with Bao Yuan decoction combined with Tao Hong Si Wu decoction (BYTH) on lung structural remodeling in rats with ischemic heart failure. In a model of myocardial infarction (MI) induced by ligation of the left anterior descending (LAD) artery, rats were treated with BYTH. Read More

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http://dx.doi.org/10.5582/bst.2018.01242DOI Listing
January 2018
8 Reads

Late onset cardiac cirrhosis and portal hypertensive ascites after atrial fibrillation ablation.

Pulm Circ 2019 Jan-Mar;9(1):2045894018813559. Epub 2018 Nov 13.

2 CardioVascular Thoracic Institute, Keck School of Medicine, Los Angeles, CA, USA.

Pulmonary vein stenosis is a potential complication following catheter ablation of atrial fibrillation (AF). We report the case of a patient with refractory ascites late after multiple catheter ablation procedures for AF. This is the first case report of portal hypertensive ascites due to acquired multiple pulmonary vein stenoses resulting in pulmonary hypertension (PH) and cardiac cirrhosis late after AF ablation. Read More

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http://dx.doi.org/10.1177/2045894018813559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300167PMC
November 2018
1 Read

A literature review of immersion pulmonary edema.

Phys Sportsmed 2018 Nov 7:1-4. Epub 2018 Nov 7.

b Division of Cardiology , Hartford Hospital , Hartford , CT , USA.

Importance: Immersion pulmonary edema (IPE) is a rare but important complication associated with surface swimming and underwater diving. It tends to reoccur and can be fatal. It is not very well-known to clinicians involved in the care of individuals participating in aquatic activities. Read More

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https://www.tandfonline.com/doi/full/10.1080/00913847.2018.1
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http://dx.doi.org/10.1080/00913847.2018.1546104DOI Listing
November 2018
13 Reads
1.490 Impact Factor

Development and Validation of a Prognostic Tool for Identifying Residents at Increased Risk of Death in Long-Term Care Facilities.

J Palliat Med 2018 Nov 7. Epub 2018 Nov 7.

3 Suzanne Dworak-Peck School of Social Work, University of Southern California , Los Angeles, California.

Background: To promote better care at the end stage of life in long-term care facilities, a culturally appropriate tool for identifying residents at the end of life is crucial.

Objective: This study aimed to develop and validate a prognostic tool, the increased risk of death (IRD) scale, based on the minimum data set (MDS).

Design: A retrospective study using data between 2005 and 2013 from six nursing homes in Hong Kong. Read More

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http://dx.doi.org/10.1089/jpm.2018.0219DOI Listing
November 2018
5 Reads

A case of pulmonary edema: The critical role of lung-heart integrated ultrasound examination.

Monaldi Arch Chest Dis 2018 10 1;88(3):982. Epub 2018 Oct 1.

CTO Hospital, Emergency Department.

Cardiogenic pulmonary edema is a common presentation of acute heart failure normally treated with continuous positive airway pressure (CPAP), diuretics and nitrates. This therapy is contraindicated in case of cardiac tamponade. We describe a case of pulmonary edema due to cardiac tamponade in which integrated lung-heart ultrasound examination allowed prompt diagnosis and pericardiocentesis before administration of CPAP thus avoiding circulatory collapse. Read More

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http://dx.doi.org/10.4081/monaldi.2018.982DOI Listing
October 2018
4 Reads

Non-invasive ventilation in cardiogenic pulmonary edema.

Ann Transl Med 2018 Sep;6(18):355

Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Cardiogenic pulmonary edema (CPE) is among the most common causes of acute respiratory failure (ARF) in the acute care setting and often requires ventilatory assistance. In patients with ARF due to CPE, use of non-invasive positive airway pressure can decrease the systemic venous return and the left ventricular (LV) afterload, thus reducing LV filling pressure and limiting pulmonary edema. In these patients, either non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) can improve vital signs and physiological parameters, decreasing the need for endotracheal intubation (ETI) and hospital mortality when compared to conventional oxygen therapy. Read More

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http://atm.amegroups.com/article/view/19394/20876
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http://dx.doi.org/10.21037/atm.2018.04.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186545PMC
September 2018
10 Reads

Cardiovascular failure and weaning.

Authors:
Philippe Vignon

Ann Transl Med 2018 Sep;6(18):354

Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.

Cardiac patients are at high risk of weaning failure due to the abrupt burden to the cardiovascular system resulting from the transition from positive-pressure ventilation to spontaneous breathing. Similarly, numerous patients with borderline cardiac function, left ventricular diastolic dysfunction, chronic obstructive pulmonary disease, especially with associated fluid overload or cumulative positive fluid balance, are at high risk of weaning failure of cardiac origin. The diagnosis of weaning-induced pulmonary oedema (WiPO) relies on the measurement of elevated left ventricular filling pressure, or on the presence of a surrogate reflecting pulmonary or cardiac congestion. Read More

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http://dx.doi.org/10.21037/atm.2018.05.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186572PMC
September 2018
1 Read

Pressure-dependent NOS activation contributes to endothelial hyperpermeability in a model of acute heart failure.

Biosci Rep 2018 Dec 23;38(6). Epub 2018 Nov 23.

Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, U.S.A.

Acute increases in left ventricular end diastolic pressure (LVEDP) can induce pulmonary edema (PE). The mechanism(s) for this rapid onset edema may involve more than just increased fluid filtration. Lung endothelial cell permeability is regulated by pressure-dependent activation of nitric oxide synthase (NOS). Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181239
Publisher Site
http://dx.doi.org/10.1042/BSR20181239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250809PMC
December 2018
7 Reads

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4).

J Med Chem 2018 Nov 18;61(21):9738-9755. Epub 2018 Oct 18.

A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported TRPV4 inhibitor (1). Several core-structure modifications were identified that improved TRPV4 activity by increasing structural rigidity and reducing the entropic energy penalty upon binding to the target protein. The new template was initially discovered as a minor regio-isomeric side product formed during routine structure-activity relationship (SAR) studies, and further optimization resulted in highly potent compounds with a novel pyrrolidine diol core. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01317DOI Listing
November 2018
1 Read

Fluid management in extensive liposuction: A retrospective review of 83 consecutive patients.

Medicine (Baltimore) 2018 Oct;97(41):e12655

Department of Plastic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu.

Tumescent anesthesia makes it feasible to perform liposuction in an office setting. There are often patients who desire extensive liposuction on approximately 30% of total body surface area, which means the potential of fluid overload. In this study, the charts of 83 patients undergoing extensive liposuction were retrospectively reviewed. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0003
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http://dx.doi.org/10.1097/MD.0000000000012655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203531PMC
October 2018
5 Reads

[Anesthesia and Anesthesia-related Technology].

Kyobu Geka 2018 09;71(10):725-728

Department of Anesthesiology and Pain Medicine, Dokkyo Medical University School of Medicine, Tochigi, Japan.

Although there is no remarkable change of anesthetics or anesthesia methods in recent years, several new technologies are used for safety management of cardiac, lung or thoracic surgery. Stroke volume variation (SVV) monitoring indicates SVV, a parameter to optimize fluid infusion and is used to avoid edema or congestive heart damage due to over hydration. SmartPilot View, a pharmacokinetic simulator during anesthesia, represents the measured effective site concentration of anesthetics and contributes the optimization of induction and maintenance of anesthesia. Read More

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September 2018
7 Reads

Bedside Ultrasound Versus Chest Radiography for Detection of Pulmonary Edema: A Prospective Cohort Study.

J Ultrasound Med 2018 Oct 2. Epub 2018 Oct 2.

Department of Graduate Medical Education, Mount Carmel Health System, Columbus, Ohio, USA.

Objectives: Chest radiography has been the preferred imaging study to assess pulmonary congestion. However, chest radiography interpretation is influenced by the level of expertise and high interobserver variability. Lung ultrasound (US) may produce more objective findings through evaluation of vertical comet tail artifacts known as B-lines, which are created by a decrease in the ratio of alveolar air to fluid pulmonary content. Read More

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http://doi.wiley.com/10.1002/jum.14781
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http://dx.doi.org/10.1002/jum.14781DOI Listing
October 2018
2 Reads

T-wave alternans in a case with systemic lupus erythematosus-related myocarditis.

J Cardiol Cases 2018 Oct 23;18(4):119-122. Epub 2018 Jun 23.

Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.

A 42-year-old woman presented with fever, dyspnea, lower-leg edema, significant pulmonary congestion, pleural effusion, and severely reduced left ventricular contractions. She was resistant to treatment for heart failure, including catecholamines, furosemide, phosphodiesterase III inhibitors, and human atrial natriuretic peptide, and antibiotics failed to reduce her inflammation. She had renal dysfunction and hypocomplementemia and was positive for anti-nuclear and anti-ds-DNA antibodies. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149622PMC
October 2018
3 Reads

A Risk Stratification Model for Cardiovascular Complications during the 3-Month Period after Major Elective Vascular Surgery.

Biomed Res Int 2018 9;2018:4381527. Epub 2018 Sep 9.

Clinic for Cardiothoracic and Transplantation Surgery, Clinical Center Nis, 18000 Nis, Serbia.

Introduction: The Revised Cardiac Risk Index (RCRI) is an extensively used simple risk stratification tool advocated by the European Society of Cardiology and European Society of Anesthesiology (ESC/ESA).

Purpose: The aim of this study was to find the best model for predicting 3-month cardiovascular complications in elective major vascular surgical patients using preoperative clinical assessment, calculation of the RCRI and Vascular Physiological and Operative Severity Score for the enumeration of mortality and morbidity (V-POSSUM) scores, and the preoperative levels of N-terminal brain natriuretic peptide (NT pro-BNP), high-sensitivity troponin I (hs TnI), and high-sensitivity C-reactive protein (hs CRP).

Materials And Methods: We included 122 participants in a prospective, single-center, observational study. Read More

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https://www.hindawi.com/journals/bmri/2018/4381527/
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http://dx.doi.org/10.1155/2018/4381527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151200PMC
January 2019
17 Reads

Management of Heart Failure in the Emergency Department Setting: An Evidence-Based Review of the Literature.

J Emerg Med 2018 Nov 26;55(5):635-646. Epub 2018 Sep 26.

Department of Emergency Medicine, Rush University Medical Center, Chicago, Illinois.

Background: Acute heart failure (AHF) is a common presentation to the emergency department (ED), with the potential to cause significant morbidity and mortality. It is important to tailor treatments to the appropriate type of heart failure.

Objectives: This review provides an evidence-based summary of the current ED management of acute heart failure. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.08.002DOI Listing
November 2018
9 Reads

Management of fluid status and cardiovascular function in patients with diffuse skin inflammation.

J Dermatolog Treat 2018 Nov 19:1-5. Epub 2018 Nov 19.

e Department of Pulmonary and Critical Care, Wake Forest School of Medicine , Winston-Salem , NC , USA.

Background: Skin inflammation causes vasodilation and increased vascular permeability, which may result in decreased blood pressure and peripheral edema. Patients with erythroderma usually compensate for low blood pressure with fluid retention and increased cardiac output. However, if the heart cannot support increased cardiac output, blood pressure will stay low, resulting in severe compensatory fluid retention, which leads to decompensated congestive heart failure, and pulmonary edema. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1528328DOI Listing
November 2018
15 Reads

Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide.

J Clin Endocrinol Metab 2018 Dec;103(12):4365-4372

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Context: Diazoxide, the only U.S. Food and Drug Administration-approved drug to treat hyperinsulinemic hypoglycemia, has been associated with several adverse events, which has raised concerns about the safety of this drug. Read More

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http://dx.doi.org/10.1210/jc.2018-01613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207144PMC
December 2018
1 Read

Positive Pressure Ventilation in the Cardiac Intensive Care Unit.

J Am Coll Cardiol 2018 Sep;72(13):1532-1553

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Contemporary cardiac intensive care units (CICUs) provide care for an aging and increasingly complex patient population. The medical complexity of this population is partly driven by an increased proportion of patients with respiratory failure needing noninvasive or invasive positive pressure ventilation (PPV). PPV often plays an important role in the management of patients with cardiogenic pulmonary edema, cardiogenic shock, or cardiac arrest, and those undergoing mechanical circulatory support. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183572
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http://dx.doi.org/10.1016/j.jacc.2018.06.074DOI Listing
September 2018
9 Reads
16.503 Impact Factor

Pulmonary Ultrasound in Patients with Heart Failure - Systematic Review.

Arq Bras Cardiol 2018 Jun;110(6):577-584

Programa de Pós-graduação em Ciências Cardiovasculares da Universidade Federal Fluminense (UFF), Niterói, RJ - Brazil.

Pulmonary congestion is an important clinical finding in patients with heart failure (HF). Physical examination and chest X-ray have limited accuracy in detecting congestion. Pulmonary ultrasound (PU) has been incorporated into clinical practice in the evaluation of pulmonary congestion. Read More

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http://dx.doi.org/10.5935/abc.20180097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023636PMC

A Long-Term Survivor with Tetralogy of Fallot Treated Only with the Classical Blalock-Taussig Shunt.

Case Rep Cardiol 2018 19;2018:5262745. Epub 2018 Aug 19.

Department of Pediatrics, University of Tsukuba, Ibaraki, Japan.

The prognosis of tetralogy of Fallot (TOF) treated only with Blalock-Taussig shunt (BTS) operation is unclear. A woman with TOF underwent classic BTS operation at 10 years of age. Despite no medication, she delivered two children and worked without apparent heart failure. Read More

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https://www.hindawi.com/journals/cric/2018/5262745/
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http://dx.doi.org/10.1155/2018/5262745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120336PMC
August 2018
3 Reads

Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Trends Cardiovasc Med 2018 Aug 17. Epub 2018 Aug 17.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, United States; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

Heart failure with preserved ejection fraction (HFpEF) is defined as clinical features of heart failure, ideally with biomarker evidence such as elevated plasma natriuretic peptide levels, in the setting of an ejection fraction (EF) greater than 50% and imaging evidence of diastolic left ventricular dysfunction [1,2]. In the absence of cardiac imaging or invasive hemodynamics, this is a clinical syndrome that is often indistinguishable from heart failure with reduced ejection fraction (HFrEF). HFpEF and HFrEF present with a cadre of comparable signs and symptoms including jugular venous distention, pulmonary rales on auscultation, breathlessness, orthopnea, exercise intolerance, exertional dyspnea, fatigue and peripheral edema. Read More

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http://dx.doi.org/10.1016/j.tcm.2018.08.005DOI Listing
August 2018
18 Reads