29,507 results match your criteria Congestive Heart Failure Imaging


Coronary artery dissection following aortic valve replacement. How can one deal with this rare yet life-threatening complication?

J Card Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland.

Coronary artery dissection following its cannulation for cardioplegia administration as a result of aortic valve replacement (AVR) is a rare but nevertheless life-threatening complication. The three cases of a patient suffering from aortic stenosis illustrated below focus on the issue of how to identify and treat the dissected artery. In all of the patients who had undergone AVR diagnosed was a periprocedural myocardial infarction. Read More

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http://dx.doi.org/10.1111/jocs.13995DOI Listing
February 2019

Recommendations on the use of innovative medical technologies in cardiology and cardiac surgery and solutions leading to increased availability for Polish patients.

Cardiol J 2019 Feb 14. Epub 2019 Feb 14.

Abbott Health Economics & Reimbursement.

There is a great need for innovative technologies that will improve the health and quality of life (QoL) of Polish patients with cardiac problems. It is important that the safety and effectiveness of the technology are confirmed by scientific evidence on which guidelines and clinical recommendations are based. Scientific evidence for medical devices is also increasingly important for decision-making in finance approval from public funds. Read More

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http://dx.doi.org/10.5603/CJ.a2019.0007DOI Listing
February 2019

Prediction of sudden cardiac death in chronic heart failure patients with reduced ejection fraction by ADMIRE-HF risk score and early repolarization pattern.

J Nucl Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiology, Osaka General Medical Center, 3-1-56, Mandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.

Background: AdreView myocardial imaging for risk evaluation in heart failure (ADMIRE-HF) risk score is a novel risk score to predict serious arrhythmic risk in chronic heart failure patients with reduced ejection fraction (HFrEF). Moreover, early repolarization pattern (ERP) has been shown to be associated with an increased risk of sudden cardiac death (SCD) in HFrEF patients. We sought to investigate the prognostic value of combining ADMIRE-HF risk score and ERP to predict SCD in HFrEF patients. Read More

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http://dx.doi.org/10.1007/s12350-019-01639-6DOI Listing
February 2019

Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging.

J Nucl Cardiol 2019 Feb 13. Epub 2019 Feb 13.

U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.

Background: The predictors of outcome in patients with de novo diagnosis of heart failure (HF) with reduced ejection fraction (HFrEF) are poorly known.

Methods And Results: All consecutive HFrEF patients admitted between October 2012 and November 2017 with their first episode of HF were scheduled for an outpatient follow-up. After 3 months, patients with confirmed HFrEF underwent Iodine-123 Meta-Iodobenzylguanidine imaging. Read More

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http://dx.doi.org/10.1007/s12350-019-01637-8DOI Listing
February 2019

Senile Systemic Amyloidosis: An Underdiagnosed Disease.

Eur J Case Rep Intern Med 2017 21;4(9):000725. Epub 2017 Sep 21.

Internal Medicine Department, Hospital de Egas Moniz, Lisbon, Portugal.

Senile systemic amyloidosis is caused by a non-mutated form of transthyretin with the heart being the major organ involved. This infiltrative cardiomyopathy usually presents as slowly progressive heart failure. An 82-year-old female patient was admitted for newly diagnosed heart failure. Read More

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http://dx.doi.org/10.12890/2017_000725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346851PMC
September 2017

Pathophysiology of right ventricular failure in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: a pictorial essay for the interventional radiologist.

Insights Imaging 2019 Feb 13;10(1):18. Epub 2019 Feb 13.

Radiology Department, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.

Pulmonary embolus (PE) is the third most common cause of cardiovascular death with more than 600,000 cases occurring in the USA per year. About 45% of patients with acute PE will have acute right ventricular failure, and up to 3.8% of patients will develop chronic thromboembolic pulmonary hypertension (CTEPH) with progressive, severe, chronic heart failure. Read More

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http://dx.doi.org/10.1186/s13244-019-0695-9DOI Listing
February 2019

Ventricular remodeling in preterm infants: computational cardiac magnetic resonance atlasing shows significant early remodeling of the left ventricle.

Pediatr Res 2018 Nov 19. Epub 2018 Nov 19.

Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Premature birth is associated with ventricular remodeling, early heart failure, and altered left ventricular (LV) response to physiological stress. Using computational cardiac magnetic resonance (CMR) imaging, we aimed to quantify preterm ventricular remodeling in the neonatal period, and explore contributory clinical factors.

Methods: Seventy-three CMR scans (34 preterm infants, 10 term controls) were performed to assess in-utero development and preterm ex-utero growth. Read More

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http://dx.doi.org/10.1038/s41390-018-0171-0DOI Listing
November 2018

Incremental value of extracellular volume assessment by cardiovascular magnetic resonance imaging in risk stratifying patients with suspected myocarditis.

Int J Cardiovasc Imaging 2019 Feb 12. Epub 2019 Feb 12.

Non-invasive Cardiovascular Imaging, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Cardiovascular magnetic resonance imaging (CMR) has become a key investigative tool in patients with suspected myocarditis. However, the prognostic implications of T1 mapping, including extracellular volume (ECV) calculation, is less clear. Patients with suspected myocarditis who underwent CMR evaluation, including T1 mapping at our institution were included. Read More

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http://dx.doi.org/10.1007/s10554-019-01552-6DOI Listing
February 2019

Axial Muscle Size as a Strong Predictor of Death in Subjects With and Without Heart Failure.

J Am Heart Assoc 2019 Feb;8(4):e010554

1 Hospital of the University of Pennsylvania Philadelphia PA.

Background The impact of skeletal muscle size, quantified using simple noninvasive images routinely obtained during cardiac magnetic resonance imaging studies on mortality in the heart failure ( HF ) population is currently unknown. Methods and Results We prospectively enrolled 567 subjects without HF (n=364), with HF with reduced ejection fraction (n=111), or with HF with preserved ejection fraction (n=92), who underwent a cardiac magnetic resonance imaging. Skeletal muscle cross-sectional area was assessed with manual tracing of major thoracic muscle groups on axial chest magnetic resonance images. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.010554
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http://dx.doi.org/10.1161/JAHA.118.010554DOI Listing
February 2019
7 Reads

Value of combined cardiopulmonary and echocardiography stress test to characterize the haemodynamic and metabolic responses of patients with heart failure and mid-range ejection fraction.

Eur Heart J Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Cardiac, Thoracic and Vascular Department, University of Pisa, Via Paradisa, 2, Pisa, Italy.

Aims: To characterize heart failure (HF) with mid-range ejection fraction (HFmrEF), combining cardiopulmonary exercise test, and exercise stress echocardiography.

Methods And Results: We studied 169 consecutive subjects (age 62.3 ± 11 years; 74% male): 30 healthy controls, 45 patients with HF and preserved EF (HFpEF), 40 HFmrEF, and 54 with HF and reduced EF (HFrEF). Read More

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http://dx.doi.org/10.1093/ehjci/jez014DOI Listing
February 2019

Echocardiographic Findings in Cardiac Amyloidosis: Inside Two-Dimensional, Doppler, and Strain Imaging.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Clinical and Experimental Medicine Department, Cardiology Unit, University of Messina, Azienda Ospedaliera Universitaria 'Policlinico G. Martino,' Via Consolare Valeria 1, 98125, Messina, Italy.

Purpose Of Review: The aim is to provide a description of the most important echocardiographic features in systemic amyloidosis.

Recent Findings: Amyloidosis is a heterogeneous group of multisystem disorders, characterized by an extracellular deposition of amyloid fibrils. Several imaging tests are available for the diagnosis; however, echocardiography is the cornerstone of the non-invasive imaging modality for cardiac amyloidosis. Read More

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http://dx.doi.org/10.1007/s11886-019-1094-zDOI Listing
February 2019

Mitral Prolapse: An Old Mysterious Entity - The Incremental Role of Multimodality Imaging in Sports Eligibility.

J Cardiovasc Echogr 2018 Oct-Dec;28(4):207-217

Luigi Vanvitelli University, Monaldi Hospital, AORN Ospedali Dei Colli, Naples, Italy.

Mitral valve prolapse is generally a benign condition characterized by fibromyxomatous changes of the mitral leaflet with displacement into the left atrium and late-systolic regurgitation. Although it is an old clinical entity, it still arouses perplexity in diagnosis and clinical management. Complications, such as mitral regurgitation (MR), atrial fibrillation, congestive heart failure, endocarditis, ventricular arrhythmias, and sudden cardiac death (SCD), have been reported. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_42_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341849PMC
February 2019

Clinical manifestations, diagnosis, and treatment of ischemic mitral regurgitation: a review.

J Thorac Dis 2018 Dec;10(12):6969-6986

Department of Cardiology, Hospital Universitario de Canarias, Tenerife, Spain.

Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. Read More

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http://jtd.amegroups.com/article/view/25085/19483
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http://dx.doi.org/10.21037/jtd.2018.10.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344722PMC
December 2018
2 Reads

N-terminal-pro-b-type natriuretic peptide levels and cardiac hemosiderosis in adolescent β-thalassemia major patients.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):32-37

Department of Child Health, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Iron-induced cardiomyopathy remains the leading cause of mortality in patients with β-thalassemia major. Iron overload cardiomyopathy, which may be reversible through iron chelation, is characterized by early diastolic dysfunction. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker of diastolic dysfunction. Read More

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http://dx.doi.org/10.4103/apc.APC_49_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343373PMC
February 2019

Economic impact of introducing TYRX amongst patients with heart failure and reduced ejection fraction undergoing implanted cardiac device procedures: a retrospective model based cost analysis.

J Med Econ 2019 Feb 12. Epub 2019 Feb 12.

a Department of Cardiology , Guy's and St Thomas' NHS Foundation Trust , London , UK.

Background And Aims: Infection is a serious and expensive complication of Cardiac Implantable Electronic Device (CIED) procedures. We performed a retrospective based cost analysis to estimate Trust level savings of using the TYRX antibacterial envelope as a primary prevention measure against infection in a tertiary referral centre in South London, United Kingdom.

Methods: A retrospective cohort of heart failure patients with reduced ejection fraction undergoing Implantable Cardioverter Defibrillator (ICD) or Cardiac Resynchronization Therapy (CRT) procedures were evaluated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1581621DOI Listing
February 2019

Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling.

J Mol Cell Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Departments of Anesthesiology, Medicine/Cardiology, Physiology, David Geffen School of Medicine at UCLA, 650 Charles Young Dr., Los Angeles, CA 90095, United States. Electronic address:

Heart failure is associated with hypertrophying of cardiomyocytes and changes in transcriptional activity. Studies from rapidly dividing cells in culture have suggested that transcription may be compartmentalized into factories within the nucleus, but this phenomenon has not been tested in vivo and the role of nuclear architecture in cardiac gene regulation is unknown. While alterations to transcription have been linked to disease, little is known about the regulation of the spatial organization of transcription and its properties in the pathological setting. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.003DOI Listing
February 2019

Computed Tomography Appearance of Uncorrected Congenital Heart Disease in Adults.

J Thorac Imaging 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiology, University Hospital, Rutgers New Jersey Medical School, Newark, NJ.

The incidence of congenital heart disease (CHD) is about 4 to 10 per 1000 live births. While severe forms of CHD are usually diagnosed in infancy or childhood, milder and more survivable CHD may first manifest in the adult or may be discovered incidentally on imaging studies performed for other reasons. It is important to identify CHD in adults to implement appropriate treatment and prevent complications such as progression of pulmonary hypertension and development of heart failure. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000397DOI Listing
February 2019

Current spectrum, challenges and new developments in the surgical care of adults with congenital heart disease.

Authors:
Jürgen Hörer

Cardiovasc Diagn Ther 2018 Dec;8(6):754-764

Department of Pediatric Cardiology and Congenital Heart Disease, Hôpital Marie Lannelongue, Université Paris-Sud, Le Plessis Robinson, France.

Today, more than two thirds of patients with congenital heart disease (CHD) are adults. Cardiac surgery plays an essential role in restoring and maintaining cardiac function, aside from evolving medical treatment and catheter-based interventions. The aim of the present publication was to describe the spectrum of operations performed on adults with CHD (ACHD) by reviewing current literature. Read More

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http://dx.doi.org/10.21037/cdt.2018.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331376PMC
December 2018
1 Read

The Diagnostic and Clinical Approach to Pediatric Myocarditis: A Review of the Current Literature.

Open Access Maced J Med Sci 2019 Jan 4;7(1):162-173. Epub 2019 Jan 4.

Medical School, University of Prishtina, Prishtina, Kosovo.

Myocarditis is an inflammatory disease of the myocardium with a broad spectrum of clinical presentations, ranging from mild symptoms to severe heart failure. The course of patients with myocarditis is heterogeneous, varying from partial or full clinical recovery in a few days to advanced low cardiac output syndrome requiring mechanical circulatory support or heart transplantation. Myocarditis is a very heterogeneous disease, especially in the pediatric age group as worldwide disease myocarditis has been defined by the World Health Organization/International Society and Federation of Cardiology as an inflammatory disease of the heart muscle diagnosed by established histological, immunologic, and immunohistological criteria. Read More

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http://dx.doi.org/10.3889/oamjms.2019.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352488PMC
January 2019
1 Read

Impacts of non-recovery of trastuzumab-induced cardiomyopathy on clinical outcomes in patients with breast cancer.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, South Korea.

Objectives: The impacts of non-recovery of trastuzumab-induced left ventricular dysfunction (LVD) on clinical outcomes in breast cancer have been poorly studied. We investigated the predictors of LV-functional non-recovery and its impacts on clinical outcomes in breast cancer patients with trastuzumab-induced LVD.

Methods And Results: A total of 243 patients with trastuzumab-induced LVD were divided into the recovered LVD group (n = 195) and non-recovered LVD group (n = 48). Read More

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http://dx.doi.org/10.1007/s00392-019-01417-xDOI Listing
February 2019
4.560 Impact Factor

Evaluation after Orthotopic Heart Transplant: What the Radiologist Should Know.

Radiographics 2019 Feb 8:180141. Epub 2019 Feb 8.

From the Departments of Radiology (J.D.S., J.T.S., S.M.J., M.L.R.d.C.), Cardiology (K.K.J.), and Medicine (A.M.), University of Missouri-Kansas City School of Medicine, Kansas City, Mo; Department of Radiology, Saint-Luke's Hospital of Kansas City, 4401 Wornall Rd, Kansas City, MO 64111 (J.D.S., S.M.J., M.L.R.d.C.); Department of Radiology, Medical College of Wisconsin, Milwaukee, Wis (S.L.D.); and Department of Cardiovascular Diseases, St. Luke's Mid America Heart Institute, Kansas City, Mo (A.M.).

Orthotopic heart transplant (OHT) is the treatment of choice for end-stage heart disease. As OHT use continues and postoperative survival increases, multimodality imaging evaluation of the transplanted heart will continue to increase. Although some of the imaging is performed and interpreted by cardiologists, a substantial proportion of images are read by radiologists. Read More

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http://dx.doi.org/10.1148/rg.2019180141DOI Listing
February 2019

SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob mice.

Cardiovasc Diabetol 2019 Feb 7;18(1):16. Epub 2019 Feb 7.

Bioscience, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, Mölndal, 431 83, Gothenburg, Sweden.

Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first class of anti-diabetes treatment that reduces mortality and risk for hospitalization due to heart failure. In clinical studies it has been shown that SGLT2i's promote a general shift to fasting state metabolism characterized by reduced body weight and blood glucose, increase in glucagon/insulin ratio and modest increase in blood ketone levels. Therefore, we investigated the connection between metabolic changes and cardiovascular function in the ob/ob mice; a rodent model of early diabetes with specific focus on coronary microvascular function. Read More

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http://dx.doi.org/10.1186/s12933-019-0820-6DOI Listing
February 2019

Risk factors for atrial fibrillation in hypertrophic cardiomyopathy.

Eur J Prev Cardiol 2019 Feb 6:2047487319828474. Epub 2019 Feb 6.

2 The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Atrial fibrillation is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in approximately 25% of patients, which is four to six times more common than in similarly aged patients of the general population. Atrial fibrillation is poorly tolerated by HCM patients, largely due to their dependence on atrial systole for left ventricular filling. HCM patients who develop atrial fibrillation have an increased rate of heart failure related mortality and disabling or fatal thromboembolic events, as well as functional deterioration due to progressive heart failure when left untreated. Read More

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http://dx.doi.org/10.1177/2047487319828474DOI Listing
February 2019
3 Reads

Acute Iloprost Inhalation Improves Right Ventricle Function in Pulmonary Artery Hypertension: A Cardiac Magnetic Resonance Study.

Front Pharmacol 2018 21;9:1550. Epub 2019 Jan 21.

Tianjin Medical University General Hospital, Tianjin, China.

Right ventricle (RV) function is among the most important prognostic factors for pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of the prostacyclin family, is effective for the treatment of severe PAH and acute RV failure. However, the acute effects of iloprost on RV physiology have not been thoroughly explored in the past. Read More

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http://dx.doi.org/10.3389/fphar.2018.01550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348276PMC
January 2019
1 Read

Usefulness of Left Ventricular Strain by Cardiac Magnetic Resonance Feature-Tracking to Predict Cardiovascular Events in Patients With and Without Heart Failure.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania. Electronic address:

There is controversy regarding the utility of left ventricular (LV) mechanics assessed by feature-tracking steady-state free-precession (FT-SSFP), a readily implementable technique in clinical practice. In particular, whether LV mechanics assessed by FT-SSFP predicts outcomes in subjects with heart failure (HF) with reduced ejection fraction (HFrEF), with preserved ejection fraction (HFpEF), or without HF is unknown. We aimed to assess whether LV mechanics measured with FT-SSFP cine magnetic resonance imaging (MRI) predicts adverse outcomes. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.025DOI Listing
January 2019
1 Read

Pathophysiology and Echocardiographic Diagnosis of Left Ventricular Diastolic Dysfunction.

J Am Soc Echocardiogr 2019 Feb;32(2):216-232.e2

Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

Echocardiography is the primary imaging modality used for the clinical evaluation of left ventricular (LV) diastolic function. Using two-dimensional together with transmitral, mitral annular, and pulmonary venous Doppler data, conclusions may be drawn regarding the relaxation and compliance properties of the ventricle that can be used for estimating LV filling pressure. Echocardiographic estimation of LV filling pressure has been shown to be especially useful for evaluating patients with dyspnea of unknown etiology as well as those with heart failure with preserved ejection fraction. Read More

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http://dx.doi.org/10.1016/j.echo.2018.11.011DOI Listing
February 2019

Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.

ACS Nano 2019 Feb 8. Epub 2019 Feb 8.

School of Biomedical Sciences, Faculty of Biological Sciences , University of Leeds , Leeds LS2 9JT , United Kingdom.

Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) calcium channel, is tightly clustered within these nanodomains. Super-resolution microscopy has previously been used to visualize RyR clusters near the cell surface. Read More

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http://dx.doi.org/10.1021/acsnano.8b08742DOI Listing
February 2019
1 Read

Haemodynamic management of patients with left ventricular assist devices using echocardiography: the essentials.

Eur Heart J Cardiovasc Imaging 2019 Jan 30. Epub 2019 Jan 30.

Department of Anaesthesiology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.

Mechanical circulatory support with continuous-flow left ventricular assist devices (LVADs) has emerged as a viable treatment modality for patients with advanced heart failure. LVAD support results in unique haemodynamic and echocardiographic alterations that must be understood to provide optimal care for these patients. In this review, we propose essential echocardiographic and haemodynamic elements for the assessment of optimal LVAD function based on the literature and the use of simulation software. Read More

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http://dx.doi.org/10.1093/ehjci/jez003DOI Listing
January 2019

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.

Eur J Heart Fail 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, CARIM School for Cardiovascular Diseases Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. Read More

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http://doi.wiley.com/10.1002/ejhf.1406
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http://dx.doi.org/10.1002/ejhf.1406DOI Listing
February 2019
2 Reads
6.526 Impact Factor

A family with Danon disease caused by a splice site mutation in LAMP2 that generates a truncated protein.

Mol Genet Genomic Med 2019 Feb 3:e561. Epub 2019 Feb 3.

Department of Echocardiography, Zhongshan Hospital, Shanghai Institute of Cardiovascular Disease, Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China.

Background: Danon disease is an X-linked dominant hereditary condition caused by mutations in the gene encoding lysosomal-associated membrane protein 2 (LAMP2), leading to failure of lysosome binding to autophagosomes, accumulation of glycogen in the heart, and abnormal cardiac function.

Methods: We describe identification of a mutation in LAMP2, c.741+1G>T, in a family with Danon disease by whole exome sequencing. Read More

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http://dx.doi.org/10.1002/mgg3.561DOI Listing
February 2019

A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients.

Kidney Int 2019 Jan 29. Epub 2019 Jan 29.

Comprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany; Department of Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.

Mineralocorticoid receptor antagonists have beneficial effects on left ventricular remodeling, cardiac fibrosis, and arrhythmia in heart failure, but efficacy and safety in dialysis patients is less clear. We evaluated the effect of spironolactone on left ventricular mass (LVM), an independent predictor of all-cause and cardiovascular mortality, in hemodialysis patients. In this placebo-controlled, parallel-group trial, 97 hemodialysis patients (23% female; mean age 60. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.025DOI Listing
January 2019
1 Read

Gene Transfer of Calcium-Binding Proteins into Adult Cardiac Myocytes.

Methods Mol Biol 2019 ;1929:187-205

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.

Heart failure is the leading cause of combined morbidity and mortality in the USA with 50% of cases being diastolic heart failure. Diastolic heart failure results from poor myocardial relaxation and inadequate filling of the left ventricular chamber caused in part by calcium-handling dysregulation. In this chapter we describe methods to investigate new approaches of novel human Ca binding protein motifs to restore normal Ca handling function to diseased myocardium. Read More

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http://dx.doi.org/10.1007/978-1-4939-9030-6_12DOI Listing
January 2019

Cardiomyocyte substructure reverts to an immature phenotype during heart failure.

J Physiol 2019 Feb 1. Epub 2019 Feb 1.

Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.

Key Points: As reactivation of the foetal gene program has been implicated in pathological remodelling during heart failure (HF), we examined whether cardiomyocyte subcellular structure and function revert to an immature phenotype during this disease. Surface and internal membrane structures appeared gradually during development, and returned to a juvenile state during HF. Similarly, dyadic junctions between the cell membrane and sarcoplasmic reticulum were progressively 'packed' with L-type Ca2+ channels and Ryanodine Receptors during development, and 'unpacked' during HF. Read More

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http://dx.doi.org/10.1113/JP277273DOI Listing
February 2019

Prognostic value of left atrial function by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy.

Int J Cardiovasc Imaging 2019 Jan 31. Epub 2019 Jan 31.

Cardiology Department, University Hospital Ramón y Cajal, Carretera de Colmenar Km 9.100, 28034, Madrid, Spain.

Left atrium (LA) size has an important role in determining prognosis and risk stratification in hypertrophic cardiomyopathy (HCM). Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a novel technique for the quantification of LA function. Our aim was first to evaluate LA function by CMR-FT and volumetric analysis in patients with HCM; and secondly we sought to determine the association of LA-longitudinal strain (LA-LS) with major cardiovascular outcomes, particularly all cause mortality and heart failure. Read More

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http://dx.doi.org/10.1007/s10554-019-01534-8DOI Listing
January 2019

Rationale and design of a prospective, randomised study of retrograde application of bone marrow aspirate concentrate (BMAC) through coronary sinus in patients with congestive heart failure of ischemic etiology (the RETRO study).

BMC Cardiovasc Disord 2019 Jan 31;19(1):32. Epub 2019 Jan 31.

Department of Science and Research, University Hospital Ostrava, Ostrava, Czech Republic.

Background: Heart failure (HF) is a major chronic illness and results in high morbidity and mortality. The most frequent cause of HF with reduced ejection fraction (HFREF) is coronary artery disease (CAD). Although revascularisation of ischemic myocardium lead to improvements in myocardial contractility and systolic function, it cannnot restore the viability of the already necrotic myocardium. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-019-1011-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357383PMC
January 2019
5 Reads

A risk scoring model to predict renal progression associated with postcontrast acute kidney injury in chronic kidney disease patients.

Medicine (Baltimore) 2019 Feb;98(5):e14377

Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Postcontrast acute kidney injury (AKI) occurs more frequently in patients with lower estimated glomerular filtration rate. We hypothesized that postcontrast AKI in chronic kidney disease (CKD) patients with distinct risk factors might be associated with accelerated renal progression.We undertook this retrospective cohort study to develop and validate a risk scoring model for predicting renal progression. Read More

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http://dx.doi.org/10.1097/MD.0000000000014377DOI Listing
February 2019

Constrictive pericarditis in a patient with inherited factor VII deficiency.

Ter Arkh 2018 Aug;90(7):86-90

National Research Center for Hematology, Moscow, Russia.

Constrictive pericarditis (CP) is the final stage of a chronic inflammatory process characterized by fibrous thickening and calcification of the pericardium that impairs diastolic filling, reduces cardiac output, and ultimately leads to heart failure. We present a clinical case of CP in a patient with rare inherited bleeding disorder - factor VII deficiency. Heart failure due to CP was suspected based on clinical symptoms, results of ultrasonic and radiological investigations. Read More

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http://dx.doi.org/10.26442/terarkh201890786-90DOI Listing
August 2018
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Perspectives of using pulmonary arterial stiffness indicators to evaluate the prognosis  of patients with pulmonary arterial hypertension.

Ter Arkh 2018 Feb;90(1):86-92

Almazov National Medical Research Centre.

Aim: The aim of the study was to characterize the mechanical properties of the pulmonary arterial wall (PA) in patients with pulmonary arterial hypertension (PAH) using magnetic resonance imaging (MRI) of the heart, and to determine their diagnostic and prognostic value.

Materials And Methods: 57 patients with PAH were examined. The diagnosis of PAH was verified according to the recommendations of the ERS/ESC from 2015. Read More

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http://dx.doi.org/10.26442/terarkh201890186-92DOI Listing
February 2018

Cardiovascular imaging in cardio-oncology.

J Thorac Dis 2018 Dec;10(Suppl 35):S4351-S4366

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Cancer therapy may lead to cardiovascular complications and can promote each aspect of cardiac disease manifestation, such as vascular disease including coronary heart disease, myocardial diseases including heart failure, structural heart diseases including valvular heart diseases, and rhythm disorders. All potential complications of cancer therapy onto the cardiovascular system require imaging for diagnostic workup as well as monitoring of therapy. Transthoracic echocardiography (TTE) is the most frequently used tool for assessment of cardiac function during or after cancer therapy in daily clinical routine. Read More

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http://dx.doi.org/10.21037/jtd.2018.10.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328388PMC
December 2018

Left Ventricular Assist Device Associated Gastrointestinal Bleeding: Recognition of an Iatrogenic Etiology on Technetium-99m Tagged Red Blood Cell Scintigraphy.

J Nucl Med Technol 2019 Jan 29. Epub 2019 Jan 29.

Mayo Clinic in Arizona, United States.

Technetium-99m (Tc) tagged RBC scintigraphy is the imaging modality of choice in the diagnosis of active gastrointestinal bleeding (GIB). Continuous-flow left ventricular assist devices (CF-LVADs) are the state-of-the-art treatment for advanced heart failure, with GIB as the most common complication. Recognition of the distinctive imaging feature of CF-LVADs on scintigraphic images could aid diagnosis of GIB. Read More

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http://dx.doi.org/10.2967/jnmt.118.220061DOI Listing
January 2019

Myocardial triglycerides in cardiac amyloidosis assessed by proton cardiovascular magnetic resonance spectroscopy.

J Cardiovasc Magn Reson 2019 Jan 31;21(1):10. Epub 2019 Jan 31.

Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092, Zurich, Switzerland.

Background: Cardiac involvement of amyloidosis leads to left-ventricular (LV) wall thickening with progressive heart failure requiring rehospitalization. Cardiovascular magnetic resonance (CMR) is a valuable tool to non-invasively assess myocardial thickening as well as structural changes. Proton CMR spectroscopy (H-CMRS) additionally allows assessing metabolites including triglycerides (TG) and total creatine (CR). Read More

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http://dx.doi.org/10.1186/s12968-019-0519-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354424PMC
January 2019

Uhl Anomaly in Asymptomatic Adult Woman.

Circ Cardiovasc Imaging 2019 Feb;12(2):e008277

Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, University Tor Vergata, Rome, Italy (M.F., L.P., R.F., M.C.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008277DOI Listing
February 2019

Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure.

J Postgrad Med 2019 Jan-Mar;65(1):44-46

Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Read More

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http://www.jpgmonline.com/text.asp?2019/65/1/44/250961
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http://dx.doi.org/10.4103/jpgm.JPGM_701_17DOI Listing
January 2019
3 Reads

Management of Arrhythmias Associated with Cardiac Sarcoidosis.

Korean Circ J 2019 Feb;49(2):119-133

Department of Cardiology, Kyorin University School of Medicine, Tokyo, Japan.

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. The annual incidence of systemic sarcoidosis is estimated at 10-20 per 100,000 individuals. Owing to the recent advances in imaging modalities, cardiac sarcoidosis (CS) is diagnosed more frequently. Read More

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http://dx.doi.org/10.4070/kcj.2018.0432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351276PMC
February 2019
2 Reads

Anemia and iron deficiency in heart failure: a review of echocardiographic features.

Echocardiography 2019 Jan 28. Epub 2019 Jan 28.

Chief of the Department of Cardiology, Parc Taulí University Hospital (Universitat Autònoma de Barcelona), Barcelona, Spain.

Anemia and iron deficiency are often associated with heart failure, influencing the symptoms and prognosis. Correction of anemia and iron deficiency improves functional capacity and decreases hospitalizations. Many studies have analyzed echocardiographic parameters in iron deficiency and anemia and their evolution after iron treatment; however, the heterogeneity of the results makes it difficult to draw conclusions. Read More

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http://doi.wiley.com/10.1111/echo.14271
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http://dx.doi.org/10.1111/echo.14271DOI Listing
January 2019
5 Reads