45,308 results match your criteria Congestive Heart Failure Imaging


Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5 year and longer-term modelled outcomes of the ADDITION-Leicester study.

Diabetes Metab Res Rev 2018 Dec 6:e3111. Epub 2018 Dec 6.

Leicester Diabetes Centre, University of Leicester, Leicester, UK.

Aims: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes related complications in screen-detected patients. Read More

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December 2018

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

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December 2018

Diastolic wall strain as a predictor of age-related cardiovascular events in patients with preserved left ventricular ejection fraction.

Heart Vessels 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, Department of Medicine II, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, 573-1010, Osaka, Japan.

Diastolic wall strain (DWS) was reported as a simple and feasible echocardiographic index in assessing left ventricular (LV) diastolic stiffness. We sought to evaluate whether DWS predicts age-related cardiovascular events. Patients referred for transthoracic echocardiogram, those with preserved LV ejection fraction and no clinical heart failure were studied. Read More

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December 2018

Tolerance to Sodium in Patients With CKD-Induced Metabolic Acidosis: Does the Accompanying Anion Matter?

Am J Kidney Dis 2018 Dec 3. Epub 2018 Dec 3.

University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address:

Patients with chronic kidney disease (CKD) continue to produce endogenous acids but have a reduction in net acid excretion, resulting in a primary decrease in serum bicarbonate concentration, which is termed chronic metabolic acidosis. Recent prospective studies, along with retrospective cohort analyses, demonstrate a higher risk for CKD progression with untreated metabolic acidosis. To normalize serum bicarbonate levels, acidemic patients are often treated with sodium bicarbonate (NaHCO) or sodium citrate, which have been shown to slow the progression of CKD. Read More

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December 2018

Mitral valve velocity time integral and passive leg raise as a measure of volume responsiveness.

Crit Ultrasound J 2018 Dec 2;10(1):32. Epub 2018 Dec 2.

Department of Emergency Medicine, Ben Taub Hospital, Baylor College of Medicine, 1400 Taub Loop, Houston, TX, USA.

Background: Fluid responsiveness is an important topic for clinicians. Aggressive hydration has been shown to lead to worse outcomes. The aim of this study was to investigate the sensitivity and specificity of mitral valve (MV) velocity time integral (VTI) as a non-invasive marker of volume responsiveness. Read More

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December 2018

A real-world study of cardiac events in > 3700 patients with HER2-positive early breast cancer treated with trastuzumab: final analysis of the OHERA study.

Breast Cancer Res Treat 2018 Nov 30. Epub 2018 Nov 30.

The Christie, Manchester, UK.

Purpose: Cardiac dysfunction risk associated with intravenous trastuzumab (H IV) treatment may differ in real-world practice versus randomized trials. We investigated cardiac events in patients with HER2-positive early breast cancer (EBC) treated with H IV as adjuvant therapy in routine practice.

Methods: The observational study of cardiac events in patients with HER2-positive EBC treated with Herceptin (OHERA; NCT01152606) enrolled patients with stage I-IIIb disease eligible for H IV in the adjuvant setting per the European Summary of Product Characteristics (SmPC). Read More

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November 2018

The Effect of Lower Body Positive Pressure on Left Ventricular Ejection Duration in Patients With Heart Failure.

Dose Response 2018 Oct-Dec;16(4):1559325818811543. Epub 2018 Nov 25.

Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA.

Lower body positive pressure (LBPP) treadmill activity might benefit patients with heart failure (HF). To determine the short-term effects of LBPP on left ventricular (LV) function in HF patients, LV ejection duration (ED), a measure of systolic function was prospectively assessed in 30 men with stable HF with LV ejection fraction ≤ 40% and 50 healthy men (N). Baseline measurements (100% body weight), including blood pressure (BP), heart rate (HR) and LVED, obtained via radial artery applanation tonometry, were recorded after 2 minutes of standing on weight support treadmill and after LBPP achieving reductions of 25%, 50%, and 75% of body weight in random sequence. Read More

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November 2018

Protein-Losing Enteropathy and Plastic Bronchitis After the Fontan Operation.

Authors:
Christine Peyton

Crit Care Nurse 2018 Dec;38(6):e5-e12

Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.

Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More

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December 2018

Patients Prescribed Direct-acting Oral Anticoagulants Have Low Risk of Post-Polypectomy Complications.

Clin Gastroenterol Hepatol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gastroenterology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, United States.

Background & Aims: Use of direct-acting oral anticoagulants (DOACs) is increasing, but little is known about the associated risks in patients undergoing colonoscopy with polypectomy. We aimed to determine the risk of post-polypectomy complications in patients prescribed DOACs.

Methods: We performed a retrospective analysis using the Clinformatics Data Mart Database (a de-identified administrative database from a large national insurance provider) to identify adults who underwent colonoscopy with polypectomy or endoscopic mucosal resection (EMR) from January 1, 2011, through December 31, 2015. Read More

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November 2018
1 Read

Changes in frailty status in a community-dwelling cohort of older adults: The VERISAÚDE study.

Maturitas 2019 Jan 15;119:54-60. Epub 2018 Nov 15.

Universidade da Coruña, Gerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, 15071 A Coruña, Spain. Electronic address:

Objectives: Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The objectives of this study were to explore natural frailty transition rates at 1-year follow-up and to identify the main determinants of such transitions.

Study Design: Prospective longitudinal study covering a representative sample of community-dwelling older adults aged ≥65 years (n = 749) at baseline, and transition information at 1-year follow-up (n = 537). Read More

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January 2019

Canrenone on cardiovascular mortality in congestive heart failure: Canrenone effects on cardiovascular mortality in patients with congestive heart failure: The coffee-IT study.

Pharmacol Res 2018 Nov 28. Epub 2018 Nov 28.

Medical and Surgery Sciences Department, University of Bologna, Bologna, Italy.

Aim: To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation.

Methods: We enrolled 502 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of 10 years: 166 patients were in therapy with canrenone, while 336 patients were in conventional therapy. Read More

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November 2018

Can the Laparoscopic Approach for Adhesive Small Bowel Obstruction be Used in Octogenarians? An Observational Study Using ACS NSQIP.

J Surg Res 2019 Jan 7;233:345-350. Epub 2018 Sep 7.

Department of Surgery, Hofstra Northwell School of Medicine, Hempstead, New York.

Background: With the population of octogenarians projected to increase fourfold by 2050, we sought to compare outcomes of laparoscopic versus open approach in octogenarians requiring surgery for adhesive small bowel obstruction (SBO).

Methods/materials And Methods: Using 2006-2015 American College of Surgeons National Surgical Quality Improvement Project, we identified patients aged ≥80 y who underwent emergency surgery within 1 d of admission for SBO. Risk variables of interest included age, sex, race, body mass index, preoperative sepsis, and American Society of Anesthesiologists (ASA) classification. Read More

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January 2019

Predictors of 30 Day Readmission Following Percutaneous Cholecystostomy.

J Surg Res 2019 Jan 26;233:1-7. Epub 2018 Jul 26.

Department of Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Background: High-risk patients undergoing cholecystectomy may experience increased morbidity and mortality. Percutaneous cholecystostomy (PC) has been utilized as a treatment option for acute cholecystitis in this cohort. Little is known about risk factors for readmission following PC. Read More

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January 2019

Home-based rehabilitation interventions aimed at congestive heart failure: Are we there yet?

Eur J Prev Cardiol 2018 Nov 30:2047487318816783. Epub 2018 Nov 30.

1 Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital and University of Southern Denmark, Denmark.

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November 2018

Renal and extrarenal effects of fibroblast growth factor 23.

Authors:
Marc Vervloet

Nat Rev Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Amsterdam Cardiovascular Sciences and Department of Nephrology, Amsterdam University Medical Center, Amsterdam, Netherlands.

Fibroblast growth factor 23 (FGF23) is a hormone with a central role in the regulation of phosphate homeostasis. This regulation is accomplished by the coordinated modulation of renal phosphate handling, vitamin D metabolism and parathyroid hormone secretion. Patients with kidney disease have increased circulating levels of FGF23 and in other patient populations and in healthy individuals, FGF23 levels also rise following an increase in dietary phosphate intake. Read More

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December 2018

Unlike Native Hip Fractures, Delay to Periprosthetic Hip Fracture Stabilization Does Not Significantly Affect Most Short-Term Perioperative Outcomes.

J Arthroplasty 2018 Nov 12. Epub 2018 Nov 12.

Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT.

Background: The incidence of periprosthetic hip fractures is increasing due to higher numbers of total hip arthroplasties being performed. Unlike native hip fractures, the effect of time to surgery of periprosthetic hip fractures is not well established. This study evaluates the effect of time to surgery on perioperative complications for patients with periprosthetic hip fractures. Read More

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November 2018

High thoracic sympathetic block improves coronary microcirculation disturbance in rats with chronic heart failure.

Microvasc Res 2018 Dec 1;122:94-100. Epub 2018 Dec 1.

Department of Cardiac Ultrasound, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Introduction: Coronary microcirculation disturbance plays an important role in chronic heart failure (CHF). High thoracic sympathetic block (HTSB) is effective to treat CHF, but its impact on coronary microcirculation is unclear.

Methods: Forty male Wistar rats were subcutaneously injected with isoproterenol (340 mg/kg) for 2 days. Read More

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December 2018
1 Read

Obesity in COPD: Comorbidities with Practical Consequences?

COPD 2018 Dec 4:1-8. Epub 2018 Dec 4.

a Department of Pulmonary Disease , Rijnstate hospital , Arnhem , Netherlands.

COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPD) and non-obese COPD (COPD) individuals was studied. Read More

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December 2018
3 Reads

A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure.

J Vet Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.

Background: Pathophysiologic mechanisms for the development and progression of degenerative mitral valve disease (DMVD) remain elusive. Increased concentrations of circulating trimethylamine N-oxide (TMAO) and its precursors choline and l-carnitine are associated with the presence and severity of heart disease in people.

Objectives: To determine if differences exist in plasma concentrations of TMAO, choline, or l-carnitine among dogs with DMVD and congestive heart failure (CHF), dogs with asymptomatic DMVD, and healthy control dogs. Read More

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December 2018
3 Reads

Pregnancy with Takayasu's Arteritis: A Case Report and Literature Review.

Cureus 2018 Sep 26;10(9):e3370. Epub 2018 Sep 26.

Obstetrics and Gynecology, Women's Wellness and Research Center/ Hamad Medical Corporation, Doha , QAT.

Takayasu's arteritis (TA) is a rare and chronic inflammatory disease of the large vessels. It affects women of reproductive age and leads to an increased risk of cardiovascular complications, such as hypertension and congestive heart failure. We are presenting a case of a pregnant woman with TA, who was seen and managed at a tertiary care institute and ultimately enjoyed a favorable outcome. Read More

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September 2018
1 Read

Stem cells transplantation positively modulates the heart-kidney cross talk in cardiorenal syndrome type II.

Int J Cardiol 2019 Jan 16;275:136-144. Epub 2018 Oct 16.

Dept. Cardiac Thoracic, Vascular Sciences and Public Health, University of Padua, Italy. Electronic address:

Introduction: We investigated the effects of human amniotic fluid stem cells (hAFS) and rat adipose tissue stromal vascular fraction GFP-positive cells (rSVC-GFP) in a model of cardio-renal syndrome type II (CRSII).

Methods And Results: RHF was induced by monocrotaline (MCT) in 28 Sprague-Dawley rats. Three weeks later, four million hAFS or rSVC-GFP cells were injected via tail vein. Read More

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January 2019

Clinical features of canine pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.

J Vet Intern Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Background: Histologic features of pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description.

Objectives: To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH.

Animals: Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small-sized to medium-sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both. Read More

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November 2018

Hot spotting surgical patients undergoing hepatopancreatic procedures.

HPB (Oxford) 2018 Nov 26. Epub 2018 Nov 26.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background: The burden of health care spending in the United States is a major concern, as health care costs have exponentially increased during the last three decades. The objective of the current study was to investigate the degree of cost-concentration among Medicare patients undergoing liver and pancreatic surgery.

Methods: Medicare claims data from 2013 to 2015 were used to identify patients undergoing elective liver and pancreatic resections. Read More

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November 2018

Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial.

JACC Heart Fail 2018 Dec;6(12):1011-1019

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objectives: This study sought to evaluate the influence of baseline physical activity (PA) on responses to aerobic exercise training and clinical events in outpatients with chronic systolic heart failure (HF) from the multicenter HF-ACTION (Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure) trial.

Background: The influence of baseline PA on exercise capacity, responses to exercise training and clinical outcomes in patients with chronic HF is unclear.

Methods: Of 2,130 participants who provided consent for this analysis, 1,494 patients (64%) had complete baseline PA data, using a modified version of the International Physical Activity Questionnaire-Short Form questionnaire and were included in the analysis; 742 received usual care and 752 were allocated to the exercise training group. Read More

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December 2018

Cardiac late events in German breast cancer patients: a validation study on the agreement between patient self-reports and information from physicians.

BMC Cardiovasc Disord 2018 Nov 29;18(1):218. Epub 2018 Nov 29.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany.

Background: Self-administered health-status questionnaires are important tools in epidemiology. The objective of the presented validation study is to measure the agreement between breast cancer patients' self-reports and their physicians' information on late cardiac events, and to investigate determinants of agreement. To estimate possible misclassification is an important requirement for observational studies on cardiovascular endpoints. Read More

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November 2018

Prevalence and risk factors of sleep apnoea in adult patients with CHD.

Cardiol Young 2018 Nov 29:1-7. Epub 2018 Nov 29.

1Department of Pediatric Cardiology,Tokyo Women's Medical University,Tokyo,Japan.

Background: Although sleep apnoea is an important disorder associated with cardiac events, data regarding its prevalence and risk factors in adult patients with CHD are limited.

Methods: In this study, patients underwent a sleep study in the hospital. Indications for admission were classified as heart failure, diagnostic catheterisation, interventional catheterisation, or arrhythmia. Read More

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November 2018
2 Reads

Never trust first impressions when assessing the heart of a pregnant woman.

Echocardiography 2018 Nov 29. Epub 2018 Nov 29.

UO Cardiologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

We describe the echocardiographic finding of a 35-year-old pregnant woman, referred for a clinical consultation at our institution because of congestive heart failure. She underwent echocardiography with only little information about a history of cardiac surgery during infancy. At the first sight, parasternal long axis view demonstrates normal structures, but on the apical view we diagnosed a very rare condition with typical imaging findings: Criss Cross heart. Read More

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November 2018
1 Read

Heart rate variability, multifractal multiscale patterns and their assessment criteria.

Physiol Meas 2018 Nov 28;39(11):114010. Epub 2018 Nov 28.

Faculty of Physics, Warsaw University of Technology, Complex Systems, Warsaw 00-662, Poland.

Objective: Both the central nervous system and the autonomic nervous system are complex physiological networks which modulate the heart rate. They are spatially extended, have built-in delays and work on many time scales simultaneously-nonhomogeneous networks with multifractal dynamics. The object of our research was the analysis of human heart rate variability (HRV) using the nonlinear multiscale multifractal analysis (MMA) method for several cardiovascular diseases. Read More

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November 2018

Coil and Onyx embolization of a torcular herophili dural arteriovenous fistula in a full-term neonate with advanced heart failure using a transumbilical approach.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-6. Epub 2018 Oct 1.

Neonatal dural arteriovenous fistulas (DAVFs) are rare, but if left untreated will advance to life-threatening neurological and cardiovascular compromise. Endovascular treatment is the preferred treatment modality for DAVFs. The goal of endovascular therapy is to obliterate feeding vasculature and prevent secondary complications. Read More

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October 2018

Multipolar Left Ventricular Lead Implantation in a Unique Coronary Sinus: Direct Drainage of the Posterior Vein into the Right Atrium.

J Tehran Heart Cent 2018 Apr;13(2):80-83

Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey.

The coronary sinus, whose electrical features play an important role in cardiac arrhythmias, is the integral part of the cardiac venous system. Here we describe a 67-year-old male patient with congestive heart failure who was referred to our hospital after the failure of the first cardiac resynchronization therapy defibrillator (CRT-D) implantation. During the cannulation of the coronary sinus, the separate orifice of the posterior cardiac vein was demonstrated by the retrograde filling of the coronary sinus via contrast injection into the posterior cardiac vein. Read More

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Updates in Anthracycline-Mediated Cardiotoxicity.

Front Pharmacol 2018 12;9:1262. Epub 2018 Nov 12.

CNRS, Laboratory of Biomolecules, UMR 7203, Sorbonne University, Paris, France.

Cardiotoxicity is one of the main adverse effects of chemotheraphy, affecting the completion of cancer therapies and the short- and long-term quality of life. Anthracyclines are currently used to treat many cancers, including the various forms of leukemia, lymphoma, melanoma, uterine, breast, and gastric cancers. World Health Organization registered anthracyclines in the list of essential medicines. Read More

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November 2018

Mitral valve repair versus replacement for patients with preserved left ventricular function without heart failure symptoms.

J Thorac Cardiovasc Surg 2018 Sep 26. Epub 2018 Sep 26.

Department of Cardiothoracic Surgery, Stony Brook School of Medicine, Stony Brook, NY and Department of Cardiothoracic Surgery, Mount Sinai Hospital, New York, NY.

Objective: The purposes of this study are to compare outcomes of mitral valve repair (MV-repair) and mitral valve replacement for patients with severe mitral regurgitation with preserved ventricular function and no congestive heart failure (CHF) symptoms and to examine variations in surgeon choice of procedure and outcomes by surgeon volume.

Methods: In total, 2259 consecutive patients in 42 New York State hospitals with the characteristics mentioned previously who underwent mitral valve repair (1801, 79.7%) or replacement between January 1, 2008, and December 31, 2014, were identified from a mandatory statewide clinical registry. Read More

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September 2018
1 Read
4.170 Impact Factor

Natural and synthetic peptides in the cardiovascular diseases: An update on diagnostic and therapeutic potentials.

Arch Biochem Biophys 2018 Nov 24;662:15-32. Epub 2018 Nov 24.

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131, Naples, Italy. Electronic address:

Several peptides play an important role in physiological and pathological conditions into the cardiovascular system. In addition to well-known vasoactive agents such as angiotensin II, endothelin, serotonin or natriuretic peptides, the vasoconstrictor Urotensin-II (Uro-II) and the vasodilators Urocortins (UCNs) and Adrenomedullin (AM) have been implicated in the control of vascular tone and blood pressure as well as in cardiovascular disease states including congestive heart failure, atherosclerosis, coronary artery disease, and pulmonary and systemic hypertension. Therefore these peptides, together with their receptors, become important therapeutic targets in cardiovascular diseases (CVDs). Read More

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November 2018

First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension.

Cochrane Database Syst Rev 2018 Nov 14;11:CD008170. Epub 2018 Nov 14.

Department of Pharmacology, School of Pharmacy, Fudan University, Room 605, Building 18, Lane 280, Cai Lun Road, Pudong New District, Shanghai, Shanghai, China, 201203.

Background: This is the first update of a Cochrane Review first published in 2015. Renin angiotensin system (RAS) inhibitors include angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and renin inhibitors. They are widely prescribed for treatment of hypertension, especially for people with diabetes because of postulated advantages for reducing diabetic nephropathy and cardiovascular morbidity and mortality. Read More

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November 2018
3 Reads

Pleural effusion as an indicator of short term mortality in acute pulmonary embolism.

Tuberk Toraks 2018 Sep;66(3):185-196

Department of Chest Diseases and Critical Care, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Introduction: Pulmonary embolism (PE) is known as one of the major causes of cardiovascular morbidity and mortality. Identification of high risk patients for short term and long-term mortality is crucial. The purpose of this study is to demonstrate the prognostic importance of simplified pulmonary embolism severity index (sPESI), radiological investigations and comorbidities in terms of short-term mortality by simultaneous assessment of sPESI score, pulmonary computed tomography (CT) angiography findings and underlying comorbidities in patients diagnosed with acute pulmonary embolism. Read More

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September 2018
2 Reads

Daratumumab, pomalidomide, and dexamethasone as a bridging therapy to autologous stem cell transplantation in a case of systemic light-chain amyloidosis with advanced cardiac involvement.

J Oncol Pharm Pract 2018 Nov 26:1078155218815305. Epub 2018 Nov 26.

2 Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

Systemic light-chain (AL) amyloidosis is a rare hematologic disorder where proteins infiltrate tissues leading to organ failure and death. Cardiac involvement, present in ∼70% of patients, determines stage and prognosis of the disease, with advanced involvement having a median survival of six months. The treatment of light-chain amyloidosis is directed at recovering organ function with therapeutic strategies following those of multiple myeloma with plasma cell-directed therapies. Read More

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November 2018
2 Reads

Diagnosis and treatment of aortic saddle embolism.

Ann Vasc Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Vascular Surgery, Qilu Hospital, Shandong University, 107, Wenhua Xi Road, Jinan, 250012, People's Republic of China. Electronic address:

Objective: Acute aortic occlusion is a rare but life-threatening medical condition that can result from aortic saddle embolism, thrombosis of an atherosclerotic aorta, or aortic dissection. Herein are described the diagnostic and therapeutic characteristics for a series of patients with aortic saddle embolism.

Methods: A retrospective review of medical records was performed for patients receiving treatment for aortic saddle embolism at a university hospital in China between January 2001 and September 2017. Read More

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November 2018
12 Reads

Anti-coagulation Drug Warfarin Contributes to Severe Adverse Outcomes in Prolonged Unsupervised Use: A Double-edged Sword.

Cureus 2018 Sep 22;10(9):e3347. Epub 2018 Sep 22.

Neurological Surgery, Haider Spine Center, Riverside, USA.

Anti-coagulation medications are widely used in clinical practice, especially in the United States as cardiac-related emergencies are on the rise. An overarching caveat in using anti-coagulation drugs as a long-term treatment regimen, such as warfarin, is that patients are closely monitored by their primary care provider. Routine monthly laboratory examinations are strictly required to assess the international normalized ratio (INR) which measures prothrombin time (PT), providing insight into how long it takes for blood to clot. Read More

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September 2018
3 Reads

Vasopressin versus norepinephrine in septic shock: a propensity score matched efficiency retrospective cohort study in the VASST coordinating center hospital.

J Intensive Care 2018 16;6:73. Epub 2018 Nov 16.

1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 Canada.

Purpose: It is not clear whether vasopressin versus norepinephrine changed mortality in clinical practice in the Vasopressin and Septic Shock Trial (VASST) coordinating center hospital after VASST was published. We tested the hypothesis that vasopressin changed mortality compared to norepinephrine using propensity matching of vasopressin to norepinephrine-treated patients in the VASST coordinating center hospital before (SPH1) and after (SPH2) VASST was published.

Methods: Vasopressin-treated patients were propensity score matched to norepinephrine-treated patients based on age, APACHE II, respiratory, renal, and hematologic dysfunction, mechanical ventilation status, medical/surgical status, infection site, and norepinephrine dose. Read More

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November 2018
5 Reads

The Role of Renal Vascular Reactivity in the Development of Renal Dysfunction in Compensated and Decompensated Congestive Heart Failure.

Kidney Blood Press Res 2018 Nov 23;43(6):1730-1741. Epub 2018 Nov 23.

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Background/aims: Reduction of renal blood flow (RBF) is commonly thought to be a causative factor of renal dysfunction in congestive heart failure (CHF), but the exact mechanism of the renal hypoperfusion is not clear. Apart from the activation of neurohormonal systems controlling intrarenal vascular tone, the cause might be altered reactivity of the renal vasculature to endogenous vasoactive agents.

Methods: To evaluate the role of this mechanism, we assessed by an ultrasonic transient-time flow probe maximum RBF responses to renal artery infusion of angiotensin II (ANG II), norepinephrine (NE) and acetylcholine (Ach) in healthy male rats and animals with compensated and decompensated CHF. Read More

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November 2018
2 Reads

Effect of elderly status on postoperative complications in patients with sinonasal cancer.

Int Forum Allergy Rhinol 2018 Nov 23. Epub 2018 Nov 23.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and complications of sinonasal cancer (SNC) patients receiving surgery. Read More

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November 2018
6 Reads

Analysis of patient factors associated with 30-day mortality after tracheostomy.

Laryngoscope 2018 Nov 22. Epub 2018 Nov 22.

Department of Otolaryngology, Henry Ford Hospital, Detroit, Michigan, U.S.A.

Objective: Mortality has been reported to be 22% to 45% in patients with a tracheostomy. To better counsel patients and families, we aimed to determine the effect of body mass index (BMI), socioeconomic status (SES), and the 17 conditions of the Charlson comorbidity index (CCI) on 30-day survival posttracheostomy.

Methods: This retrospective cohort study identified adult patients enrolled from our institution in the Global Tracheostomy Collaborative database from March 2014 to June 2015. Read More

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November 2018
2 Reads

Co-ordination of health care: the case of hospital emergency admissions.

Eur J Health Econ 2018 Nov 22. Epub 2018 Nov 22.

NORCE Norwegian Research Centre AS, Bergen, Norway.

The recognition that chronic care delivery is suboptimal has led many health authorities around the world to redesign it. In Norway, the Department of Health and Care Services implemented the Coordination Reform in January 2012. One policy instrument was to build emergency bed capacity (EBC) as an integrated part of primary care service provided by municipalities. Read More

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November 2018
3 Reads

Initial experience with intracorporeal continuous ow LVAD in pediatric patients in Poland.

Folia Med Cracov 2018 ;58(2):57-66

Department of Pediatric Cardiac Surgery, Jagiellonian University Children's Hospital, Wielicka 265, Kraków,

The Aim: The aim of the study is to present the initial experience with continuous flow left ventricle assist device (CF-LVAD) in pediatric patients with BSA below 1.5 m2.

Material And Methods: Between 2016 and 2017, CF-LVAD (the Heartware System) have been implanted in three pediatric patients in the Department of Pediatric Cardiac Surgery, Jagiellonian University, Krakow, Poland. Read More

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January 2018
1 Read

Fifty-seven-year-old man with progressive dyspnoea.

Heart 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.

Clinical Introduction: A 57-year-old man from the USA with a history of atrial fibrillation and hypertension was evaluated for progressive dyspnoea and decreased energy. The patient denied a history of congestive heart failure, systemic symptoms or myocardial infarction. He was found to have a 3/6 holosystolic murmur radiating to the axilla. Read More

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November 2018
4 Reads

Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C.

Int Heart J 2018 Nov 20. Epub 2018 Nov 20.

Mie University Research Center for Matrix Biology.

Inflammation after myocardial infarction (MI) may be a major factor influencing ventricular remodeling, leading to congestive heart failure and arrhythmia. Therefore, inflammation in the heart needs to be monitored. Tenascin-C (TNC) is an extracellular matrix molecule not normally expressed, but it is strongly upregulated when associated with active inflammation. Read More

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November 2018
2 Reads

What are the Risk Factors for One-Year Mortality in Older Patients with Chronic Kidney Disease? An Analysis of the Cleveland Clinic CKD Registry.

Nephron 2018 Nov 21:1-7. Epub 2018 Nov 21.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Background: Prognostic factors after dialysis initiation among older chronic kidney disease (CKD) patients are not well studied. In this study, we examined the risk factors associated with 1-year mortality after dialysis initiation among older CKD patients.

Methods: In this retrospective study, we included 621 CKD patients from an electronic medical record based CKD registry that was linked to the United States Renal Data System data. Read More

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November 2018
10 Reads