722 results match your criteria Congenitally Corrected Transposition


Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis.

Int J Artif Organs 2019 Jan 10:391398818823768. Epub 2019 Jan 10.

1 Clinic of Cardiovascular Surgery, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.

Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%-0. Read More

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http://dx.doi.org/10.1177/0391398818823768DOI Listing
January 2019

Utility of machine learning algorithms in assessing patients with a systemic right ventricle.

Eur Heart J Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiology III, Adult Congenital and Valvular Heart Disease, University Hospital Muenster, Albert-Schweitzer Campus 1, Muenster, Germany.

Aims: To investigate the utility of novel deep learning (DL) algorithms in recognizing transposition of the great arteries (TGA) after atrial switch procedure or congenitally corrected TGA (ccTGA) based on routine transthoracic echocardiograms. In addition, the ability of DL algorithms for delineation and segmentation of the systemic ventricle was evaluated.

Methods And Results: In total, 132 patients (92 TGA and atrial switch and 40 with ccTGA; 60% male, age 38. Read More

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http://dx.doi.org/10.1093/ehjci/jey211DOI Listing
January 2019
3.669 Impact Factor

Congenitally corrected transposition of the great vessels: evaluation with cardiac magnetic resonance imaging after double-switch repair.

Radiologia 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Radiología Pediátrica, Imagen Cardíaca Pediátrica y Cardiopatías Congénitas. Hospital La Paz, Madrid, España.

Congenitally corrected transposition of the great vessels implies double discordance: atrioventricular and ventriculoarterial. We present cardiac magnetic resonance images from a 9-year-old girl with congenitally corrected transposition of the great vessels, interventricular communication, and coarctation of the aorta who was treated with pulmonary artery banding, correction of coarctation, and posterior double switch. We also review the disease and the complications that should be evaluated after the surgical intervention. Read More

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http://dx.doi.org/10.1016/j.rx.2018.10.008DOI Listing
December 2018
1 Read

A minimally invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Pacing Clin Electrophysiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiothoracic Surgery, UCLA Medical Center, University of California Los Angeles, Los Angeles, California.

Background: Patients with systemic right ventricle (RV) often develop progressive heart failure and may benefit from cardiac resynchronization therapy (CRT); however, the optimal strategy for CRT has not been defined.

Methods: A retrospective review of all the patients with systemic RV failure undergoing a hybrid transcatheter-surgical approach was performed. Procedural technique and outcomes are reported. Read More

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http://dx.doi.org/10.1111/pace.13568DOI Listing
December 2018
2 Reads

Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial.

Int J Cardiol 2018 Nov 10. Epub 2018 Nov 10.

Department of Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam, the Netherlands. Electronic address:

Objectives: In the VAL-SERVE (Valsartan in Systemic Right Ventricle) trial, three-year valsartan treatment improved systemic ventricular function only in symptomatic patients with congenitally or with an atrial switch corrected transposition of the great arteries. The aim of the current study was to investigate the longer-term clinical outcomes after valsartan treatment.

Methods: From 2006 to 2009, 88 adults were randomly allocated 1:1 to either valsartan or placebo for three consecutive years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183430
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http://dx.doi.org/10.1016/j.ijcard.2018.11.027DOI Listing
November 2018
9 Reads

Advanced Imaging to Phenotype Patients With a Systemic Right Ventricle.

J Am Heart Assoc 2018 Oct;7(20):e009185

1 Department of Cardiovascular Sciences KU Leuven-University of Leuven Belgium.

Background Reduced ventricular function and decreased exercise capacity are widespread in adults with complete transposition of the great arteries after atrial switch ( TGA -Mustard/Senning) and congenitally corrected TGA (cc TGA ). Advanced imaging techniques may help to better phenotype these patients and evaluate exercise cardiac response. Methods and Results Thirty-three adults with a systemic right ventricle (70% TGA -Mustard/Senning, 37±9 years of age, 24% female, 94% New York Heart Association class I- II ) underwent echocardiogram, cardiopulmonary exercise testing, and cardiovascular magnetic resonance imaging at rest and during a 4-stage free-breathing bicycle test. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009185
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http://dx.doi.org/10.1161/JAHA.118.009185DOI Listing
October 2018
2 Reads

Cryoablation for Perinodal Arrhythmia Substrates in Patients With Congenital Heart Disease and Displaced Atrioventricular Conduction Systems.

JACC Clin Electrophysiol 2018 Oct 25;4(10):1328-1337. Epub 2018 Jul 25.

Adult Congenital Heart Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Objectives: The purpose of this study was to assess the safety and efficacy of cryoablation for perinodal substrates in patients with congenital heart disease (CHD) and a displaced atrioventricular (AV) conduction system or an AV conduction system location that was difficult to predict.

Background: Catheter ablation for perinodal arrhythmias in patients with CHD may incur higher risks due to unconventional or difficult to predict locations of the AV conduction system. Cryoablation carries theoretical advantages for such patients but has not been studied in this setting. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.05.026DOI Listing
October 2018
1 Read

Cardiac resynchronization therapy in congenital heart disease: Results from the German National Register for Congenital Heart Defects.

Int J Cardiol 2018 Dec 4;273:108-111. Epub 2018 Oct 4.

Department of Cardiology III, Adult Congenital and Valvular Heart Disease University Hospital Muenster, Germany. Electronic address:

Background: Cardiac resynchronization therapy (CRT) is an established option for patients with heart failure. Limited data exists on indications and outcome of CRT in contemporary congenital heart disease (CHD) patients.

Methods And Results: All patients with CRT registered in the German National Register for Congenital Heart Defects were systematically identified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183355
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http://dx.doi.org/10.1016/j.ijcard.2018.10.014DOI Listing
December 2018
3 Reads

Late recovery of sinus rhythm following perioperative complete atrioventricular block in a child with congenitally corrected transposition.

Ann Pediatr Cardiol 2018 Sep-Dec;11(3):297-299

Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA.

We report a patient with l-transposition of the great arteries who developed perioperative complete atrioventricular block at 5 years of age in conjunction with a modified double-switch operation, but had unexpected late recovery of normal sinus rhythm months later. This case highlights that even for patients with l-transposition, which is particularly vulnerable to developing both spontaneous and perioperative complete atrioventricular block, late recovery of atrioventricular node conduction may still be possible after surgery. Read More

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http://dx.doi.org/10.4103/apc.APC_22_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146847PMC
October 2018
1 Read

Transposition of the great arteries: A laterality defect in the group of heterotaxy syndromes or an outflow tract malformation?

Ann Pediatr Cardiol 2018 Sep-Dec;11(3):237-249

Department of Cardiac Sciences, King Abdulaziz Cardiac Center, Section of Pediatric Cardiology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Background/aim: Transposition of the great arteries (TGA) is traditionally classified as a "conotruncal heart defect", implying that TGA evolves from abnormal development of the outflow tract (OFT) of the embryonic heart. However, recently published genetic data suggest that TGA may be linked to laterality gene defects rather than OFT gene defects. The aim of our study was to clarify whether there is any statistically significant link between TGA and clinically diagnosed laterality defects (heterotaxy). Read More

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http://dx.doi.org/10.4103/apc.APC_24_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146851PMC
October 2018
1 Read

High-Sensitive Cardiac Troponin T and Systemic Right Ventricular Area Predict Outcomes in Adults With Congenitally Corrected Transposition.

Can J Cardiol 2018 Sep 12;34(9):1129-1136. Epub 2018 Jul 12.

Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw, Poland.

Background: Congenitally corrected transposition of the great arteries (ccTGA) is a rare clinical condition in which the morphologically right ventricle sustains systemic circulation. This congenital heart anomaly exposes patients with ccTGA to adverse events over time. Strategies to identify persons who are at high risk of clinical events will be crucial for improving patient outcomes. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.07.002DOI Listing
September 2018
11 Reads

Bridge to Transplantation With Long-Term Mechanical Assist Devices in Adults With Transposition of the Great Arteries.

Artif Organs 2018 Aug 21. Epub 2018 Aug 21.

Division of Cardiac Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Prior to the widespread adoption of the arterial switch operation, patients with transposition of the great arteries (TGA) commonly underwent atrial switch operation (Mustard or Senning). It is not uncommon for these patients to progress to end stage heart failure and increasingly ventricular assist devices (VADs) are used to support these patients as a bridge to transplantation, though there is limited experience with this worldwide. A retrospective review of our institution's VAD database was undertaken and revealed seven adult patients with a history of TGA and subsequent systemic ventricular failure were implanted with a VAD: four of whom received the VAD as a bridge to transplantation (BTT) at the time of implantation, two who were initially designated as destination therapy secondary to severe pulmonary hypertension, and one who was designated as destination therapy secondary to a high risk of life-threatening non-compliance. Read More

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http://dx.doi.org/10.1111/aor.13347DOI Listing
August 2018
3 Reads

Implantation techniques and outcomes after cardiac resynchronization therapy for congenitally corrected transposition of the great arteries.

Heart Rhythm 2018 Dec 18;15(12):1808-1815. Epub 2018 Aug 18.

Division of Pediatric Cardiology, Department of Pediatrics UCLA Medical Center, University of California, Los Angeles, Los Angeles, California; Division of Cardiology, Department of Medicine, Ahmanson/UCLA Adult Congenital Heart Disease Center, University of California, Los Angeles, Los Angeles, California.

Background: Patients with congenitally corrected transposition of the great arteries (CCTGA) are at risk of congestive heart failure (CHF). There are limited data on cardiac resynchronization therapy (CRT) techniques and long-term outcomes in this population.

Objective: The purpose of this study was to determine implantation techniques and efficacy of CRT for CCTGA. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.08.017DOI Listing
December 2018
3 Reads

Longitudinal strain by two-dimensional speckle tracking to assess ventricular function in adults with transposition of the great arteries: Can serial assessment be simplified?

Rev Port Cardiol 2018 Sep 16;37(9):739-745. Epub 2018 Aug 16.

Cardiology Department, Santa Marta Hospital, Centro Hospitalar Lisboa Central, Lisboa, Portugal.

Introduction: Transposition of the great arteries (TGA) is a rare form of congenital heart disease in which most patients reach adulthood. Right ventricular dysfunction is the most severe residual complication in long-term follow-up, both in patients treated by atrial switch and in those with congenitally corrected TGA. New echocardiographic tools such as longitudinal strain by two-dimensional (2D) speckle tracking may improve assessment of ventricular function in these patients. Read More

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http://dx.doi.org/10.1016/j.repc.2017.12.004DOI Listing
September 2018
1 Read

Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

J Am Coll Cardiol 2018 Aug 9. Epub 2018 Aug 9.

Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there are a limited number of clinical studies on the efficacy of medical therapy for systemic RV dysfunction. We performed a systematic review and meta-analysis to assess the effect of angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), beta blockers, and aldosterone antagonists in adults with systemic RVs. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.08.1030DOI Listing
August 2018
1 Read

Continuous-Flow Left Ventricular Assist Device Therapy in Adults with Transposition of the Great Vessels.

Ann Thorac Cardiovasc Surg 2018 Aug 10. Epub 2018 Aug 10.

Division of Cardiothoracic Transplantation and Circulatory Support, Baylor College of Medicine, Houston Texas, USA.

An increasing number of children with congenital heart disease are surviving into adulthood and subsequently developing end-stage heart failure. Two example populations are adults who have been previously operated on for congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA). Implantation of a continuous flow left ventricular assist device (CF-LVAD) in these patients can present unusual anatomical and physiologic challenges. Read More

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http://dx.doi.org/10.5761/atcs.cr.18-00021DOI Listing
August 2018
1 Read

Congenitally Corrected Transposition of the Great Arteries in a Septuagenarian from the Developing Country of Pakistan.

Cureus 2018 Jun 5;10(6):e2737. Epub 2018 Jun 5.

Department of Paediatrics & Child Health, Aga Khan University Hospital, Karachi, PAK.

Congenitally corrected transposition of the great arteries (CCTGA) is a rare congenital cardiac defect with atrioventricular and ventriculoarterial discordance which leads to heart failure and limits patients' lifespan. We report the case of a 70-year-old lady, from a poor province in Pakistan, who presented for the first time with palpitations and was diagnosed to have CCTGA. She had moderate pulmonic valve stenosis which was protective against heart failure. Read More

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https://www.cureus.com/articles/12808-congenitally-corrected
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http://dx.doi.org/10.7759/cureus.2737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075644PMC
June 2018
8 Reads

Implantable cardioverter defibrillator therapy in grown-up patients with transposition of the great arteries-role of anti-tachycardia pacing.

J Thorac Dis 2018 Jun;10(Suppl 15):S1769-S1776

Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

Background: Grown-up patients with surgically corrected dextro-transposition of the great arteries (dTGA) as well as patients with congenitally corrected transposition of the great arteries (ccTGA) carry a high risk of ventricular arrhythmias. Data regarding implantable cardioverter defibrillator (ICD) therapy and efficacy of anti-tachycardia pacing in these patients is limited.

Methods: Clinical data from a contemporary cohort of ICD carriers with atrial switch-corrected dTGA and burdened right ventricle or with ccTGA were obtained retrospectively from hospital records and patients were followed for additional 25 months prospectively. Read More

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http://dx.doi.org/10.21037/jtd.2018.01.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035964PMC
June 2018
9 Reads

Live-Born Major Congenital Heart Disease in Denmark: Incidence, Detection Rate, and Termination of Pregnancy Rate From 1996 to 2013.

JAMA Cardiol 2018 Sep;3(9):829-837

Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Importance: The occurrence of major congenital heart disease (CHD) is affected by several variables. Determining the development of the true incidence is critical to the establishment of proper treatment of these patients.

Objective: To evaluate time trends in incidence, detection rate, and termination of pregnancy (TOP) rate of major CHD in fetuses in Denmark and assess the influence of the introduction of general prenatal screening in 2004. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233653PMC
September 2018
13 Reads

Anatomy of the ventricular septal defect in congenital heart defects: a random association?

Orphanet J Rare Dis 2018 Jul 18;13(1):118. Epub 2018 Jul 18.

Université Paris Descartes, Sorbonne Paris Cité, 149 rue de Sevres, 75004, Paris, France.

Background: A ventricular septal defect (VSD) is an integral part of most congenital heart defects (CHD). To determine the prevalence of VSD in various types of CHD and the distribution of their anatomic types.

Methods: We reviewed 1178 heart specimens with CHD from the anatomic collection of the French Reference Centre for Complex Congenital Heart Defects. Read More

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http://dx.doi.org/10.1186/s13023-018-0861-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052685PMC
July 2018
14 Reads

Making complex pathology simple: added value of 3D transthoracic echocardiography in an adult patient with congenitally corrected transposition of great arteries and severe tricuspid regurgitation.

Eur Heart J Cardiovasc Imaging 2018 11;19(11):1311

Cardiac Division, Department of Echocardiography, Royal Brompton and Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, Chelsea, London, UK.

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http://dx.doi.org/10.1093/ehjci/jey100DOI Listing
November 2018
8 Reads
3.670 Impact Factor

Augmented-reality computed tomography-guided transcatheter pacemaker implantation in dextrocardia and congenitally corrected transposition of great arteries.

Cardiol J 2018 ;25(3):412-413

Department of Interventional Cardiology and Angiology, Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland.

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http://dx.doi.org/10.5603/CJ.2018.0058DOI Listing
December 2018
11 Reads

Late diagnosis of a congenitally corrected transposition of the great arteries discovered at pacemaker implantation in a patient previously diagnosed with dextrocardia and situs solitus.

Clin Case Rep 2018 Jun 22;6(6):1112-1116. Epub 2018 Apr 22.

Université Catholique de Louvain CHU UCL Namur Service de Cardiologie 1 Av Dr G Therasse 5530 Yvoir Belgium.

Congenitally corrected transposition of the great arteries (CCTGA) should not be missed in patients with dextrocardia and situs solitus. We report a case of a 56-year-old man with late diagnosis of CCTGA after ventricular lead replacement. Free LV wall pacing may be favorable in these patients so to prevent deterioration of the systemic RV function. Read More

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http://dx.doi.org/10.1002/ccr3.1541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986062PMC
June 2018
6 Reads

"Will she live a long happy life?" Parents' concerns for their children with Fontan circulation.

Int J Cardiol Heart Vasc 2018 Mar 9;18:65-70. Epub 2018 Mar 9.

Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Background: Families of children at the worst end of the congenital heart disease endure a significant burden which is often not clearly delineated in the clinical literature. We examined the greatest concerns of parents whose children have a Fontan circulation.

Methods: Parents ( = 107) of children in the Australian and New Zealand Fontan Registry completed online surveys with open-ended and closed questions. Read More

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http://dx.doi.org/10.1016/j.ijcha.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988481PMC
March 2018
12 Reads

Long-Term Outcomes of Tricuspid Valve Surgery in Patients With Congenitally Corrected Transposition of the Great Arteries.

J Am Heart Assoc 2018 Mar 16;7(6). Epub 2018 Mar 16.

Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Background: Valvuloplasty is generally considered unsuccessful in patients with congenitally corrected transposition of the great arteries. Optimal timing of tricuspid valve surgery in these patients is crucial.

Methods And Results: We retrospectively reviewed 57 patients with congenitally corrected transposition of the great arteries undergoing tricuspid valve surgery at our institution. Read More

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http://dx.doi.org/10.1161/JAHA.117.008127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907565PMC
March 2018
2 Reads

Utility of a super-flexible three-dimensional printed heart model in congenital heart surgery.

Interact Cardiovasc Thorac Surg 2018 Nov;27(5):749-755

Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

Objectives: The objective of this study was to assess the utility of 3D printed heart models of congenital heart disease for preoperative surgical simulation.

Methods: Twenty patient-specific 3D models were created between March 2015 and August 2017. All operations were performed by a young consultant surgeon who had no prior experience with complex biventricular repair. Read More

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http://dx.doi.org/10.1093/icvts/ivy160DOI Listing
November 2018
2 Reads

Congenital heart disease in adults: Assessmentof functional capacity using cardiopulmonary exercise testing.

Rev Port Cardiol 2018 May;37(5):399-405

Cardiology Department, Santa Marta Hospital, Lisbon, Portugal.

Aim: The aim of the study was to compare functional capacity in different types of congenital heart disease (CHD), as assessed by cardiopulmonary exercise testing (CPET).

Methods: A retrospective analysis was performed of adult patients with CHD who had undergone CPET in a single tertiary center. Diagnoses were divided into repaired tetralogy of Fallot, transposition of the great arteries (TGA) after Senning or Mustard procedures or congenitally corrected TGA, complex defects, shunts, left heart valve disease and right ventricular outflow tract obstruction. Read More

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http://dx.doi.org/10.1016/j.repc.2017.09.020DOI Listing
May 2018
1 Read

Ventricular arrhythmia burden after transcatheter versus surgical pulmonary valve replacement.

Heart 2018 Nov 10;104(21):1791-1796. Epub 2018 Apr 10.

Division of Cardiology, Ahmanson/UCLA Adult Congenital Heart Disease Center, Los Angeles, California, USA.

Objective: Comparative ventricular arrhythmia (VA) outcomes following transcatheter (TC-PVR) or surgical pulmonary valve replacement (S-PVR) have not been evaluated. We sought to compare differences in VAs among patients with congenital heart disease (CHD) following TC-PVR or S-PVR.

Methods: Patients with repaired CHD who underwent TC-PVR or S-PVR at the UCLA Medical Center from 2010 to 2016 were analysed retrospectively. Read More

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http://dx.doi.org/10.1136/heartjnl-2017-312769DOI Listing
November 2018
4 Reads

Adult Congenital Heart Disease with Pregnancy.

Authors:
Koichiro Niwa

Korean Circ J 2018 Apr;48(4):251-276

Department of Cardiology, Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan.

The number of women with congenital heart disease (CHD) at risk of pregnancy is growing because over 90% of them are grown-up into adulthood. The outcome of pregnancy and delivery is favorable in most of them provided that functional class and systemic ventricular function are good. Women with CHD such as pulmonary hypertension (Eisenmenger syndrome), severe left ventricular outflow stenosis, cyanotic CHD, aortopathy, Fontan procedure and systemic right ventricle (complete transposition of the great arteries [TGA] after atrial switch, congenitally corrected TGA) carry a high-risk. Read More

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http://dx.doi.org/10.4070/kcj.2018.0070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889976PMC
April 2018
5 Reads

Successful pregnancies after transvenous cardiac resynchronization therapy in a woman with congenitally corrected transposition of the great arteries.

Egypt Heart J 2017 Sep 26;69(3):219-222. Epub 2017 May 26.

Sahloul Hospital, Sousse, Tunisia.

Congenitally corrected transposition of the great arteries is a rare heart defect that can be associated with systemic ventricular dysfunction and conduction disturbances. The use of cardiac resynchronization therapy in patients with congenital heart disease is not fully established, and achievement of successful pregnancies after implantation of transvenous, biventricular system has never been described, and which resulted in a significant clinical improvement. We describe a 33-year-old female with congenitally corrected transposition of the great arteries, who achieved six pregnancies and successful vaginal deliveries. Read More

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http://dx.doi.org/10.1016/j.ehj.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883487PMC
September 2017
15 Reads

Cardiac Ventricular Contractile Responses to Chronically Increased Afterload Secondary to Right Ventricular Outflow Obstruction in Patients With Tetralogy of Fallot.

Am J Cardiol 2018 May 6;121(9):1090-1093. Epub 2018 Feb 6.

Pediatric Cardiology and Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama, Japan; Pediatrics, School of Medicine, Kitasato University, Kanagawa, Japan. Electronic address:

We examined the adaptive mechanism of the pulmonary ventricle (PV) in response to increased afterload secondary to pulmonary stenosis in tetralogy of Fallot (TOF, n = 47) and congenitally corrected transposition of the great arteries (cCTGA, n = 18), where the PV is morphologically different. We also elucidated the effects of such adaptation on systemic ventricular (SV) function. PV contractility, assessed by dp/dt, showed significant positive correlations with PV pressure (r = 0. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.01.014DOI Listing
May 2018
3 Reads

Outcomes of the anatomical repair in patients with congenitally corrected transposition of the great arteries: lessons learned in a high-volume centre.

Eur J Cardiothorac Surg 2018 Sep;54(3):532-538

Division of Pediatric Cardiac Surgery, University Paris Descartes and Necker Sick Children Hospital, Paris, France.

Objectives: The physiological repair of the congenitally corrected transposition of the great arteries (ccTGA) has been associated with a long-term risk of the right ventricular dysfunction and tricuspid valve regurgitation. On the other side, the anatomical repair with the restoration of the left ventricle in a systemic position has been hypothesized to improve long-term outcomes. The aim of this study was to determine the results of the anatomical repair. Read More

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http://dx.doi.org/10.1093/ejcts/ezy116DOI Listing
September 2018
13 Reads

Post-operative Assessment of the Arterial Switch Operation: A Comparison of Magnetic Resonance Imaging and Echocardiography.

Pediatr Cardiol 2018 Jun 22;39(5):1036-1041. Epub 2018 Mar 22.

Department of Pediatrics, Lillie Frank Abercrombie Section of Pediatric and Congenital Cardiology, Baylor College of Medicine/Texas Children's Hospital, 6621 Fannin St. MC 19345C, Houston, TX, 77030, USA.

After an arterial switch operation (ASO), serial imaging is necessary to monitor for maladaptive changes. We compared cardiac magnetic resonance imaging (CMR) to 2-D transthoracic echocardiography (TTE) in assessing post-operative ASO patients. We performed a retrospective review of patients at a single tertiary care center who underwent an ASO and subsequently had a CMR performed from 7/2010 to 7/2016. Read More

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http://dx.doi.org/10.1007/s00246-018-1858-zDOI Listing
June 2018
7 Reads

Right ventricular systolic dysfunction at rest is not related to decreased exercise capacity in patients with a systemic right ventricle.

Int J Cardiol 2018 06 8;260:66-71. Epub 2018 Mar 8.

Unit of Cardiology, Department of Cardiovascular Sciences, KU Leuven - University of Leuven, Leuven, Belgium; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Background: To evaluate the relationship between right ventricular (RV) systolic dysfunction at rest and reduced exercise capacity in patients with a systemic RV (sRV).

Methods: All patients with congenitally corrected transposition of the great arteries (ccTGA) or complete TGA after atrial switch (TGA-Mustard/Senning) followed in our institution between July 2011 and September 2017 who underwent cardiac imaging within a six-month time period of cardiopulmonary exercise testing (CPET) were analyzed. We assessed sRV systolic function with TAPSE and fractional area change on echocardiogram and, if possible, with ejection fraction, global longitudinal and circumferential strain on cardiac magnetic resonance (CMR) imaging. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.03.029DOI Listing
June 2018
6 Reads

Inter- and intra-ventricular dyssynchrony in the systemic right ventricle is a surrogate marker of major cardiac events in mildly symptomatic patients.

Heart Vessels 2018 Sep 28;33(9):1086-1093. Epub 2018 Feb 28.

Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan.

The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) to evaluate the dyssynchrony and assessed whether RV dyssynchrony can be predictive of major cardiac events in their early stages in these patients. We enrolled 71 consecutive, NYHA FC < III patients with systemic RV who underwent CMR between April 1995 and December 2016. Read More

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http://dx.doi.org/10.1007/s00380-018-1144-2DOI Listing
September 2018
5 Reads

Rhythm disturbances and treatment strategies in children with congenitally corrected transposition of the great arteries.

Congenit Heart Dis 2018 May 24;13(3):450-457. Epub 2018 Feb 24.

Department of Pediatric Cardiology, Saglik Bilimleri University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research and Training Hospital, Istanbul, Turkey.

Background: We aimed to evaluate rhythm abnormalities in cases of congenitally corrected transposition of the great arteries (ccTGA) and associated treatment strategies.

Patients And Methods: This retrospective cohort study included 65 pediatric patients with ccTGA who were admitted to the clinic between 2009 and 2017. The patients were divided into two groups, and surgical data, Holter electrocardiographic (ECG) recordings, ECG recordings, electrophysiological data, and device implantation data on the two groups were compared. Read More

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http://dx.doi.org/10.1111/chd.12595DOI Listing
May 2018
8 Reads

Right ventricular dysfunction in congenitally corrected transposition of the great arteries and risk of ventricular tachyarrhythmia and sudden death.

Int J Cardiol 2018 05 31;258:83-89. Epub 2018 Jan 31.

Division of Cardiology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, United States; Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, United States.

Background: It is unknown whether systemic right ventricular (SRV) dysfunction confers increased risk for sudden death in congenitally corrected transposition of the great arteries (ccTGA). We sought to define risk of ventricular arrhythmias and sudden death attributable to systemic right ventricular dysfunction in ccTGA.

Methods: The study cohort is comprised of adult patients with a diagnosis of ccTGA. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.01.107DOI Listing
May 2018
14 Reads

An extremely rare clinical entity: congenitally corrected transposition with situs ınversus and single coronary artery presented with complete atrioventricular block in a young man.

Cardiol Young 2018 May 12;28(5):759-761. Epub 2018 Feb 12.

Department of Cardiology,Trabzon Ahi Evren Training and Research Hospital,University of Health Science,Trabzon,Turkey.

Congenitally corrected transposition of the great arteries is a rare form of CHD. Situs inversus is a much less common variant of a congenitally corrected transposition of the great arteries. In rare cases, transposition events may be accompanied by various cardiac anomalies. Read More

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http://dx.doi.org/10.1017/S1047951118000069DOI Listing
May 2018
13 Reads

Catheter ablation of manifest posteroseptal accessory pathway associated with coronary sinus diverticula in a child with congenitally corrected transposition of the great arteries.

Anatol J Cardiol 2018 Feb;19(2):149-151

Department of Pediatric Cardiology, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864812PMC
http://dx.doi.org/10.14744/AnatolJCardiol.2017.8108DOI Listing
February 2018
5 Reads

Perioperative use of transthoracic echocardiography in a patient with congenitally corrected transposition of great arteries, atrial septal defect and severe pulmonary stenosis for lower segment cesarean section.

J Anaesthesiol Clin Pharmacol 2017 Oct-Dec;33(4):544-546

Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 25-year-old female with congenitally corrected transposition of great arteries (CCTGAs), atrial septal defect, and severe pulmonary stenosis underwent lower segment cesarean section at 34 weeks of gestation using combined spinal epidural anesthesia (CSEA). We used transthoracic echocardiography (TTE) for intraoperative monitoring of the cardiovascular system because these patients are reported to have a high prevalence of myocardial perfusion defects, regional wall motion abnormalities, and impaired ventricular contractility. Scanning was done at four different time intervals; preoperatively, after initiation of CSEA, after delivery of child and postoperatively (6 and 24 h postdelivery) to detect regional wall motion and valvular abnormalities, calculate ejection fractions and optimize fluid administration. Read More

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http://dx.doi.org/10.4103/0970-9185.173342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791273PMC
February 2018
7 Reads

Systemic Right Ventricle in Adults With Congenital Heart Disease: Anatomic and Phenotypic Spectrum and Current Approach to Management.

Circulation 2018 Jan;137(5):508-518

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom (M.B., G.-P.D., M.A.G.)

The systemic right ventricle (SRV) is commonly encountered in congenital heart disease representing a distinctly different model in terms of its anatomic spectrum, adaptation, clinical phenotype, and variable, but overall guarded prognosis. The most common clinical scenarios where an SRV is encountered are complete transposition of the great arteries with previous atrial switch repair, congenitally corrected transposition of the great arteries, double inlet right ventricle mostly with previous Fontan palliation, and hypoplastic left heart syndrome palliated with the Norwood-Fontan protocol. The reasons for the guarded prognosis of the SRV in comparison with the systemic left ventricle are multifactorial, including distinct fibromuscular architecture, shape and function, coronary artery supply mismatch, intrinsic abnormalities of the tricuspid valve, intrinsic or acquired conduction abnormalities, and varied SRV adaptation to pressure or volume overload. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031544DOI Listing
January 2018
10 Reads

Contemporary management and outcomes in congenitally corrected transposition of the great arteries.

Heart 2018 Jul 11;104(14):1148-1155. Epub 2018 Jan 11.

Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, Technical University of Munich, Muenster, Germany.

Congenitally corrected transposition of the great arteries (ccTGA) can occur in isolation, or in combination with other structural cardiac anomalies, most commonly ventricular septal defect, pulmonary stenosis and tricuspid valve disease. Clinical recognition can be challenging, so echocardiography is often the means by which definitive diagnosis is made. The tricuspid valve and right ventricle are on the systemic arterial side of the ccTGA circulation, and are therefore subject to progressive functional deterioration. Read More

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http://dx.doi.org/10.1136/heartjnl-2016-311032DOI Listing
July 2018
7 Reads

Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance.

J Am Heart Assoc 2017 Dec 21;6(12). Epub 2017 Dec 21.

Division of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1161/JAHA.117.007759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779063PMC
December 2017
11 Reads

Coronary sinus ostial atresia with persistent left superior caval vein in a patient with congenitally corrected transposition of the great arteries.

Cardiol Young 2018 Mar 13;28(3):498-499. Epub 2017 Dec 13.

Department of Medical Imaging,Toronto General Hospital,Toronto, ON,Canada.

We present a case of a 57-year-old man with congenitally corrected transposition of great vessels who was found to have coronary ostial atresia with cranial flow through left superior vena cava on CT with contrast injection in coronary tributaries. As such, he was ineligible for cardiac resynchronization therapy. Read More

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http://dx.doi.org/10.1017/S1047951117002554DOI Listing
March 2018
6 Reads

Incidence and clinical characteristics of sudden cardiac death in adult congenital heart disease.

Int J Cardiol 2018 03 5;254:101-106. Epub 2017 Dec 5.

University of Sydney Medical School and Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address:

Background: The life expectancy of adults with congenital heart disease (CHD) has significantly improved in recent decades, with non-cardiovascular causes of death now competing with traditional cardiovascular causes. The risk of sudden cardiac death (SCD), a devastating event, still remains elevated above that of the general population.

Methods: We reviewed 2935 patients in our adult CHD database (age≥16years, seen at least once in our centre) and documented all cases of SCD between 2000-2015. Read More

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http://dx.doi.org/10.1016/j.ijcard.2017.11.117DOI Listing
March 2018
6 Reads

Severe subvalvular pulmonic stenosis due to a ball-shaped accessory tissue in an asymptomatic woman with congenitally corrected transposition of great arteries and mesocardia: A rare case report.

Echocardiography 2018 Jan 17;35(1):114-117. Epub 2017 Nov 17.

Faculty of Medicine, Department of Cardiology, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Congenitally corrected transposition of great arteries (CCTGA) is a rare anomaly described by atrioventricular and ventriculoarterial discordance. On the other hand, mesocardia that is extremely rare includes two relatively well-defined apexes defined by each ventricle with the major axis of the heart lies in the midline. We describe a rare case of an asymptomatic 20-year-old woman with mesocardia, CCTGA, and severe subvalvular pulmonic stenosis due to a ball-shaped accessory tissue in left ventricular outflow tract. Read More

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http://doi.wiley.com/10.1111/echo.13751
Publisher Site
http://dx.doi.org/10.1111/echo.13751DOI Listing
January 2018
12 Reads