102 results match your criteria Congenital Self-Healing Reticulohistiocytosis


Congenital self-healing reticulohistiocytosis with BRAF V600E mutation in an infant.

Clin Exp Dermatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.

Congenital self-healing reticulohistiocytosis (CSHR) is a rare disorder characterized by benign skin lesions with a tendency to self-heal. Multiple skin lesions are usually present in CSHR. It is very difficult to distinguish between CSHR and an invasive Langerhans cell histiocytosis. Read More

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http://dx.doi.org/10.1111/ced.13880DOI Listing
January 2019
2 Reads

Langerhans Cell Histiocytoma: A Benign Histiocytic Neoplasm of Diverse Lines of Terminal Differentiation.

Am J Dermatopathol 2019 Jan;41(1):29-36

Pathology Department, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Langerhans cell (LC) histiocytoma is a neonatal tumor that often consists of a single, ulcerated nodule. Systemic involvement is rare, and LC histiocytoma is considered to be a variant of congenital, self-healing LC histiocytosis (also referred to as Hashimoto-Pritzker disease). In view of its low prevalence, LC histiocytoma is not always diagnosed in a clinical examination and requires histological confirmation. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9827
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http://dx.doi.org/10.1097/DAD.0000000000001255DOI Listing
January 2019
6 Reads

A case of congenital self-healing Langerhans cell histiocytosis with two lesions.

Eur J Dermatol 2018 Aug;28(4):548-549

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.

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http://dx.doi.org/10.1684/ejd.2018.3324DOI Listing
August 2018
17 Reads

Case of Congenital Self-Healing Reticulohistiocytosis Expanding the Spectrum of Blueberry Muffin Baby.

Am J Dermatopathol 2018 Feb;40(2):136-138

Dermatology Department, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

Congenital self-healing reticulohistiocytosis (CSHRH) is a benign, rare variant of histiocytosis. This condition can present phenotypically as blueberry muffin baby. This is the case of a male neonate with skin involvement of papulonodular violaceous lesions, which resolved spontaneously. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001049DOI Listing
February 2018
5 Reads

Congenital self-healing reticulohistiocytosis with spontaneous regression.

An Bras Dermatol 2017 Jul-Aug;92(4):553-555

Department of Dermatology, Shandong Provincial Hospital of Dermatology and Venereology, Shandong University, Jinan, Shandong, China.

Congenital self-healing reticulohistiocytosis is a rare, benign, self-limiting variant of Langerhans cell histiocytosis (LCH). LCH encompasses a group of idiopathic disorders characterized by the clonal proliferation of Langerhans cells. Congenital self-healing reticulohistiocytosis typically appears at birth or in the neonatal period as isolated cutaneous lesions, often appearing as multiple crusted papules with no systemic findings. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20175432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595609PMC
October 2017
3 Reads

Congenital Self Healing Langerhans Cell Histiocytosis.

Indian J Pediatr 2018 04 19;85(4):316-317. Epub 2017 Sep 19.

Department of Neonatology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

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http://dx.doi.org/10.1007/s12098-017-2469-zDOI Listing
April 2018
4 Reads

Including Langerhans cell histiocytosis in the differential diagnosis of skin tumors with osteoclast-like multinucleated giant cells.

J Cutan Pathol 2017 May 16. Epub 2017 May 16.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cup.12954DOI Listing
May 2017
38 Reads

Congenital Self-Healing Langerhans Cell Histiocytosis.

J Pediatr 2017 05 21;184:232-232.e1. Epub 2017 Feb 21.

Section of Pediatric Dermatology Children's Hospital of Philadelphia; Department of Pediatrics and Dermatology University of PennsylvaniaPhiladelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jpeds.2017.01.040DOI Listing
May 2017
6 Reads

Congenital self-healing reticulohistiocytosis: an underreported entity.

Cutis 2016 Apr;97(4):296-300

Western University of Health Sciences, Pomona, California, and the Department of Dermatology, Pacific Hospital of Long Beach, California, USA.

Langerhans cell histiocytosis (LCH), also known as histiocytosis X, is a group of rare disorders characterized by the continuous replication of a particular white blood cell called Langerhans cells. These cells are derived from the bone marrow and are found in the epidermis, playing a large role in immune surveillance and the elimination of foreign substances from the body. Additionally, Langerhans cells are capable of migrating from the skin to lymph nodes, and in LCH, these cells begin to congregate on the bone, particularly in the head and neck region, causing a multitude of problems. Read More

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April 2016
5 Reads

Congenital self-healing reticulohistiocytosis: the need for investigation.

Australas J Dermatol 2016 Feb;57(1):76-7

Paediatric Oncology, Starship Hospital, Auckland, New Zealand.

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http://dx.doi.org/10.1111/ajd.12222DOI Listing
February 2016
4 Reads

Diverse Cutaneous Presentations of Langerhans Cell Histiocytosis in Children: A Retrospective Cohort Study.

Pediatr Blood Cancer 2016 Mar 19;63(3):486-92. Epub 2015 Nov 19.

Laboratory of Pediatric Immunology, KU Leuven, Leuven, Belgium.

Background: Langerhans cell histiocytosis (LCH) is a rare disease, frequently affecting young children.

Procedure: We performed a retrospective study in patients younger than 16 years old manifesting with skin symptoms, and documented their different cutaneous lesions and systemic symptoms. We compared subgroups of children with single-system, skin-only, and multisystem disease and sought signs predictive for multisystem disease. Read More

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http://dx.doi.org/10.1002/pbc.25834DOI Listing
March 2016
12 Reads

Congenital self-healing Langerhans cell histiocytosis in a male neonate.

Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):75-7

Department of Dermatology, Children's Hospital of Chong Qing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China.

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http://dx.doi.org/10.4103/0378-6323.148587DOI Listing
September 2015
7 Reads

Congenital self-healing reticulohistiocytosis presented with multiple hypopigmented flat-topped papules: a case report and review of literatures.

J Med Assoc Thai 2014 Sep;97(9):993-7

Congenital self-healing reticulohistiocytosis, also known as Hashimoto-Pritzker disease, is a single system Langerhans cell histiocytosis that typically presents in healthy newborns and spontaneously regresses. In the present report, we described a 2-month-old Thai female newborn with multiple hypopigmented flat-topped papules without any internal organ involvement including normal blood cell count, urinary examination, liver and renal functions, bone scan, chest X-ray, abdominal ultrasound, and bone marrow biopsy. The histopathology revealed typical findings of Langerhans cell histiocytosis, which was confirmed by the immunohistochemical staining CDla and S100. Read More

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September 2014
3 Reads

Congenital "self-healing" Langerhans cell histiocytosis (Hashimoto-Pritzker disease): a report of two cases with the same cutaneous manifestations but different clinical course.

J Dermatol 2014 Dec 30;41(12):1098-101. Epub 2014 Oct 30.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Congenital self-healing Langerhans cell histiocytosis or Hashimoto-Pritzker disease is a rare condition present at birth or in the neonatal period characterized by small reddish-brown crusted papulonodular lesions. In most cases these lesions are not accompanied by systemic findings and tend to involute spontaneously within weeks or months, but in other cases there may be extracutaneous involvement and/or recurrence of the disease. This emphasizes that the clinical course is variable and a long-term follow-up is mandatory in order to reveal possible systemic involvement. Read More

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http://dx.doi.org/10.1111/1346-8138.12670DOI Listing
December 2014
9 Reads

Solitary congenital erosion in a newborn: report of a solitary congenital self-healing reticulohistiocytosis.

Ann Dermatol 2014 Apr 30;26(2):250-3. Epub 2014 Apr 30.

Department of Dermatology, St. Paul's Hospital, School of Medicine, The Catholic University of Korea, Seoul, Korea.

Congenital self-healing reticulohistiocytosis (CSHRH) is a rare, cutaneous, self-limited form of Langerhans cell histiocytosis. Whereas multiple lesions are common, a solitary lesion is rare. A 14-day-old neonate presented with a solitary, 5-mm, oval, reddish, and eroded papule with crust on the left thigh that had existed since birth. Read More

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http://dx.doi.org/10.5021/ad.2014.26.2.250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037681PMC
April 2014
1 Read

Multisystemic Langerhans cell histiocytosis mimicking diffuse neonatal hemangiomatosis.

Pediatr Dermatol 2014 May-Jun;31(3):e87-9. Epub 2014 Mar 3.

Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.

We report the first case of multisystemic Langerhans cell histiocytes mimicking diffuse neonatal hemangiomatosis clinically. This has been described in patients with congenital self-healing reticulohistiocytosis but not in patients with acute, disseminated, and multisystemic disease. In our experience, dermoscopic findings did not help to diagnose the condition. Read More

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http://dx.doi.org/10.1111/pde.12319DOI Listing
December 2014
39 Reads

Congenital self-healing reticulohistiocytosis.

J Clin Aesthet Dermatol 2014 Feb;7(2):49-53

The authors are from Penn State/Hershey Medical Center, Hershey, Pennsylvania.

Congenital self-healing reticulohistiocytosis, also known as congenital self-healing Langerhans cell histiocytosis or Hashimoto-Pritzker disease, is a Langerhans cell histiocytosis. It is characterized by skin lesions in the newborn period in an otherwise healthy infant that show a Langerhans cell infiltrate in the skin on histological analysis. These findings subsequently spontaneously involute. Read More

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http://www.dermatol-sinica.com/web/data/200863052155.pdf
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http://www.odermatol.com/odermatology/32014/8.Congenital-She
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http://synapse.koreamed.org/Synapse/Data/PDFData/0069YMJ/ymj
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935651PMC
February 2014
5 Reads

Solitary congenital self-healing Langerhans cell histiocytosis: a benign variant of Langerhans cell histiocytosis?

Dermatol Online J 2013 Jan 15;19(1). Epub 2013 Jan 15.

University of British Columbia, Vancouver, BC, Canada.

Langerhans cell histiocytosis (LCH) represents a diverse group of diseases with various different clinical presentations and outcomes. We present two cases of solitary CSH-LCH (sCSH-LCH) and highlight certain unique characteristics including the favorable prognosis and lack of documented progression to systemic involvement in reported cases. Read More

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January 2013
4 Reads

Congenital self-healing reticulohistiocytosis: concern for a poor prognosis.

Dermatol Online J 2012 Oct 15;18(10). Epub 2012 Oct 15.

School of Medicine, University of California Davis, Sacramento, California, USA.

Congenital self-healing reticulohistiocytosis (CSHRH) is a rare type of Langerhans cell histiocytosis with potential for relapse and systemic involvement. Whereas CSHRH was traditionally considered a benign disease, there is an approximately 3 percent risk of mortality and a 10 percent chance of relapse. This article, using an extensive review of cases since Hashimoto and Pritzker first described the condition in 1973, highlights the various presentations of CSHRH and reveals high rates of relapse and systemic involvement in cases that specifically address features of CSHRH occurring within the first year of life. Read More

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October 2012
20 Reads
3 Citations

Congenital self-healing histiocytosis presenting as blueberry muffin baby: a case report and literature review.

Indian J Dermatol Venereol Leprol 2012 May-Jun;78(3):407

Clinic of Dermatovenereology, Clinical Center of Serbia, Department of Dermatovenereology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Congenital self-healing Langerhans cell histiocytosis (CSHLCH), also called as Hashimoto-Pritzker disease, is a rare, benign variant of histiocytosis. Despite the initial dramatic clinical presentation, affected infants are otherwise healthy and skin lesions disappear spontaneously within several weeks to months. We present a case of CSHLCH presenting as blueberry muffin baby. Read More

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http://dx.doi.org/10.4103/0378-6323.95482DOI Listing
September 2012
24 Reads
3 Citations
1.325 Impact Factor

[Disseminated juvenile xanthogranuloma expressing protein S100].

Ann Dermatol Venereol 2012 Feb 6;139(2):128-31. Epub 2011 Dec 6.

Service de dermatologie, hôpital Hédi-Chaker, route El Ain km 1, 3029 Sfax, Tunisie.

Background: Juvenile xanthogranuloma (JXG) is a form of self-healing non-Langerhans histiocytosis. We report a new case of disseminated JXG without visceral involvement but with positive immunostaining of the majority of histiocytes for protein S100.

Patients And Methods: A 6-month-old male infant was admitted to our department in January 2010 for congenital nodular lesions of varying size, shape and appearance. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S015196381101063
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http://dx.doi.org/10.1016/j.annder.2011.10.408DOI Listing
February 2012
4 Reads

[Congenital self-healing Langerhans cell histiocytosis].

Hautarzt 2011 Nov;62(11):804-7

Klinik für Dermatologie und Allergologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074 Aachen.

A male infant, born at term after an uncomplicated pregnancy, presented with multiple red-brown papules and nodules spread over his body. The infant's general condition was not affected and there was no systemic involvement. After only 6 weeks the lesions had healed completely without recurrence. Read More

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http://link.springer.com/10.1007/s00105-011-2244-4
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http://dx.doi.org/10.1007/s00105-011-2244-4DOI Listing
November 2011
4 Reads

Solitary Type of Congenital Self-healing Reticulohistiocytosis.

Ann Dermatol 2011 Sep 30;23 Suppl 1:S4-7. Epub 2011 Sep 30.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Congenital self-healing reticulohistiocytosis is a rare, congenital, benign, self-healing variant of Langerhans cell histiocytosis. It usually appears as multiple papules or nodules; however, occurrence of the solitary type is very rare. We report on a case of solitary congenital self-healing reticulohistiocytosis in a 29-day-old girl who presented with a papule on her sole. Read More

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http://dx.doi.org/10.5021/ad.2011.23.S1.S4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199419PMC
September 2011
4 Reads

Congenital self healing reticulohistiocytosis in a newborn (Hashimoto Pritzker).

An Bras Dermatol 2011 Jul-Aug;86(4):785-8

Policlínica Geral do Rio de Janeiro, Instituto de Pós-Graduação Médica Carlos Chagas, Rio de Janeiro, Brasil.

Congenital self-healing reticulohistiocytosis is the benign spectrum of Langerhans Cell Histiocytosis, characterized by cutaneous lesions at birth or in the neonatal period, absence of systemic manifestations and spontaneous resolution of clinical status. Despite the benign and often self-resolving course in most patients, studies show that in some cases there may be metastasis or recurrence of the disease, emphasizing that the clinical course is variable, requiring long-term follow-up. The monitoring of the patient for a long period is important to detect possible systemic involvement, as there is a report of recurrence involving the skin, mucosa, bone and pituitary gland. Read More

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February 2012
2 Reads

A singular case of congenital self-healing histiocytosis with skin, liver and atypical eye involvement.

Ocul Immunol Inflamm 2011 Oct 24;19(5):337-9. Epub 2011 Aug 24.

Department of Surgery, Ophthalmology Unit, Institute for Maternal and Child Health Burlo Garofolo, Via dell’Istria 65/1 Trieste, Italy.

Purpose: To describe a rare case of congenital self-healing Langerhans cell histiocytosis (CSHLCH) presenting with atypical eye involvement.

Design: Case report.

Methods: A female newborn presented with purpuric lesions over the trunk, limbs, and face. Read More

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http://dx.doi.org/10.3109/09273948.2010.605538DOI Listing
October 2011
21 Reads

[Solitary congenital self-healing histiocytosis (Hashimoto-Pritzker disease)].

Actas Dermosifiliogr 2011 May 22;102(4):301-3. Epub 2011 Feb 22.

Servicio de Anatomía Patológica, Hospital Universitari Joan XXIII, Tarragona, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00017310110000
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http://dx.doi.org/10.1016/j.ad.2010.07.007DOI Listing
May 2011
3 Reads

Congenital self-healing reticulohistiocytosis - an important diagnostic challenge.

Acta Paediatr 2011 May 11;100(5):784-6. Epub 2011 Jan 11.

Department of Pediatrics, Kolding Hospital, Denmark.

Aim: To present current and new knowledge on congenital self-healing reticulohistiocytosis, a benign variant of cutaneous Langerhans cell histiocytosis presenting with skin lesions in the neonatal period.

Methods: We describe and photo document two cases of this rare disease and review the literature.

Results: Only few newborns have acute access to a neonatal dermatologist, and we demonstrate how the spontaneous cutaneous involution may happen even prior to the first dermatological assessment. Read More

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http://dx.doi.org/10.1111/j.1651-2227.2010.02123.xDOI Listing
May 2011
16 Reads

Exploring the differential diagnosis of hemorrhagic vesicopustules in a newborn.

Pediatrics 2011 Jan 6;127(1):e226-30. Epub 2010 Dec 6.

Department of Dermatology, Eastern Virginia Medical School, 721 Fairfax Ave, Suite 200, Norfolk, VA 23507, USA.

Hemorrhagic vesicles in a newborn present a challenging differential diagnosis including both infectious and neoplastic disorders. Patients should be evaluated in an efficient manner to arrive at the correct diagnosis as quickly as possible. We present here an interesting case that outlines the methodical workup that ultimately revealed the diagnosis of congenital Langerhans cell histiocytosis. Read More

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http://dx.doi.org/10.1542/peds.2009-2019DOI Listing
January 2011
7 Reads

Congenital self-healing LCH: a case with lung lesions and review of the literature.

Pediatr Int 2010 Aug;52(4):e224-6

Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.1111/j.1442-200X.2010.03140.xDOI Listing
August 2010
2 Reads

A congenital, erythematous eruption.

Dermatol Online J 2010 Jul 15;16(7):15. Epub 2010 Jul 15.

Naval Branch Health Clinic, Department of Aviation Medicine, Kingsville, Texas, USA.

A 2-day-old male patient born full-term via uncomplicated vaginal delivery was seen for multiple erythematous, scaly papules that were present at birth. Physical examination showed a well-appearing male with erythematous papules with scale on his scalp, face, trunk, and bilateral upper and lower extremities. A 4 mm punch biopsy was performed on one of the representative papules on his abdomen and subsequent histopathological tests showed multiple Langerhans cells in the papillary dermis with positive CD1a and Langerin stains. Read More

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July 2010
3 Reads

Congenital Langerhans cell histiocytosis with skin and lung involvement: spontaneous regression.

Indian J Pediatr 2010 Jul 29;77(7):811-2. Epub 2010 Jun 29.

Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.

Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression. Systemic signs are generally absent. We describe a 4-month-old infant presenting with reddish brown nodular cutaneous lesions since birth with a past history suggestive of pulmonary involvement. Read More

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http://link.springer.com/10.1007/s12098-010-0104-3
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http://dx.doi.org/10.1007/s12098-010-0104-3DOI Listing
July 2010
9 Reads

Congenital solid thigh mass: a report of nonself healing form of langerhans cell histiocytosis.

J Pediatr Hematol Oncol 2010 May;32(4):312-4

Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey.

Summary: Langerhans cell histiocytosis (LCH) is very rarely seen in the pediatric age group. Self-healing is the usual clinical course in congenital LCH with cutaneous involvement. We describe a newborn with a solid mass in his thigh noticed at birth, without skin manifestations. Read More

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http://dx.doi.org/10.1097/MPH.0b013e3181c80bdfDOI Listing
May 2010
3 Reads
0.960 Impact Factor

Extensive, erosive congenital self-healing cell histiocytosis.

J Eur Acad Dermatol Venereol 2009 Jul 22;23(7):835-6. Epub 2008 Dec 22.

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http://dx.doi.org/10.1111/j.1468-3083.2008.03023.xDOI Listing
July 2009
1 Read

Self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease): two Tunisian cases.

Acta Dermatovenerol Alp Pannonica Adriat 2008 Dec;17(4):188-92

Department of Dermatology, Fattouma Bourguiba Hospital, Monastir 5000, Tunisia.

Self-healing Langerhans cell histiocytosis (SHLCH) is a rare self-limited variant of Langerhans cell histiocytosis that presents at birth or during the neonatal period. It was first described by Hashimoto and Pritzker in 1973. Subsequently, more than 70 cases have been reported in the literature. Read More

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December 2008
6 Reads

The role of BMT in childhood histiocytoses.

Bone Marrow Transplant 2008 Jun;41 Suppl 2:S8-S13

Department of Paediatric Hematology Oncology and Bone Marrow Transplantation, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy.

Childhood histiocytoses comprise two main diseases, Langerhans cell histiocytosis (LCH) and hemophagocytic lymphohistiocytosis (HLH). LCH is a rare disorder with obscure pathogenesis. Data on clonality suggested neoplastic origin, yet were not convincing. Read More

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http://www.nature.com/articles/bmt200846
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http://dx.doi.org/10.1038/bmt.2008.46DOI Listing
June 2008
4 Reads

Congenital Langerhans cell histiocytosis mimicking a "blueberry muffin baby".

J Pediatr Hematol Oncol 2008 Mar;30(3):245-8

Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.

Congenital Langerhans cell histiocytosis (LCH) is a rare condition with great diversity. A case of congenital skin-only LCH presenting as a "blueberry muffin baby" with a spontaneous regression by the age of 8 months is reported here. New insights into clinical manifestations and prognosis, which is not uniformly positive, are discussed. Read More

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http://dx.doi.org/10.1097/MPH.0b013e318161a9cbDOI Listing
March 2008
3 Reads

Congenital solitary histiocytoma: a variant of Hashimoto-Pritzker histiocytosis. A retrospective study of 8 cases.

Dermatology 2008 23;216(2):118-24. Epub 2008 Jan 23.

Service de Dermatologie, Hôpital Robert-Debré, Reims, France.

Background: Self-healing solitary-lesion Hashimoto-Pritzker histiocytosis (HPH), a rare, congenital, purely cutaneous Langerhans histiocytosis (only 30 cases reported), carries a good prognosis.

Objective: To describe the clinical and histopathological characteristics of solitary HPH.

Methods: To conduct a retrospective, observational study on 8 affected newborns. Read More

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http://dx.doi.org/10.1159/000111508DOI Listing
February 2008
3 Reads

Late-onset self-healing reticulohistiocytosis: pediatric case of Hashimoto-Pritzker type Langerhans cell histiocytosis.

J Dermatol 2007 Mar;34(3):205-9

Department of Dermatology, Osaka Red Cross Hospital, Ten'noji-ku, Osaka, Japan.

An 8-year-old otherwise healthy girl presented with a 3-month history of multiple asymptomatic, reddish-brown papules over the face and upper limbs. Histopathological and immunohistochemical examinations demonstrated an infiltrate of mononuclear cells containing abundant histiocytic cells in the dermis, and microabscess-like accumulation of the histiocytic cells in the epidermis. The histiocytic cells were positive for antibodies against S-100 protein and CD1a, but negative for anti-CD68. Read More

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http://dx.doi.org/10.1111/j.1346-8138.2007.00251.xDOI Listing
March 2007
3 Reads

Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas Children's Medical Center.

J Am Acad Dermatol 2007 Feb;56(2):290-4

Department of Pathology, Children's Medical Center Dallas, Texas, USA.

The real incidence of congenital self-healing reticulohistiocytosis (CSHR) may be underreported because of its high rate of spontaneous resolution and lack of clinical recognition. Currently, there are no criteria other than clinical that can reliably distinguish CSHR from cutaneous involvement by disseminated Langerhans cell histiocytosis (LCH). In this study we investigate the role of E-cadherin, Ki-67, and phosphorylated histone H3 (PHH3) immunohistochemical stains in distinguishing CSHR from disseminated LCH. Read More

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http://www.dermatol-sinica.com/web/data/200863052155.pdf
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http://www.odermatol.com/odermatology/32014/8.Congenital-She
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http://linkinghub.elsevier.com/retrieve/pii/S019096220602515
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http://dx.doi.org/10.1016/j.jaad.2006.09.001DOI Listing
February 2007
2 Reads

Disseminated crusted papules in a newborn.

Vojnosanit Pregl 2006 Jul;63(7):681-3

Military Medical Academy, Clinic of Dermatology, Center of Pathology and Forensic Medicine, Belgrade.

Background: Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinical presentation in a newborn it infrequently spreads to internal organs (which then portends a grave prognosis, indistinguishable from Letterer-Siwe disease). Read More

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July 2006
6 Reads

Solitary congenital self-healing reticulohistiocytosis in monozygotic twins.

Pediatr Dermatol 2006 May-Jun;23(3):273-5

Department of Dermatology, Hacettepe University School of Medicine, Sihhiye, Ankara, Turkey.

We report monozygotic twins with congenital self-healing reticulohistiocytosis, whose lesions initially presented as hemorrhagic bullae at birth with rapid progression into crusted papules the following day. Physical examination disclosed crusted papules on the right side of the neck of twin 1 and a similar solitary lesion on the lateral side of the right thumb of twin 2. Excisional biopsy specimen findings of the neck and thumb lesions were consistent with Langerhans cell histiocytosis, which was further confirmed by positive CD1a staining. Read More

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http://doi.wiley.com/10.1111/j.1525-1470.2006.00233.x
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http://dx.doi.org/10.1111/j.1525-1470.2006.00233.xDOI Listing
December 2006
7 Reads

Congenital systemic Langerhans cell histiocytosis presenting as hydrops fetalis.

Acta Paediatr 2005 Dec;94(12):1843-7

Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.

Unlabelled: Congenital Langerhans cell histiocytosis (LCH) encompasses a wide spectrum of disease involvement and severity. Congenital "self-healing" cutaneous LCH represents one end of the spectrum, whereas the case we encountered represents the other extreme. A rare case of congenital LCH with severe multiorgan involvement presenting as hydrops fetalis is described in this report. Read More

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http://dx.doi.org/10.1080/08035250500252062DOI Listing
December 2005
4 Reads

Solitary cutaneous dendritic cell tumor in a child: role of dendritic cell markers for the diagnosis of skin Langerhans cell histiocytosis.

J Am Acad Dermatol 2005 Nov;53(5):838-44

Department of Dermatology and Allergology, University of Ulm, Ulm, Germany.

We describe a child with a solitary dendritic cell (DC) tumor positive for S-100 protein, CD1a, and HLA-DR with the clinical and histopathologic features of a so-called solitary variant of congenital self-healing Hashimoto-Pritzker reticulohistiocytosis (CSHRH). CSHRH is a spontaneously regressing, benign form of Langerhans cell histiocytosis (LCH) and was thought to be a histiocytosis consisting of precursor Langerhans cells. In our study the tumor cells did not express CD68, indicating that they represent mature DCs. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S019096220502285
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http://dx.doi.org/10.1016/j.jaad.2005.07.011DOI Listing
November 2005
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Congenital Langerhans cell histiocytosis: the self-healing variety.

J Pediatr Hematol Oncol 2004 Jun;26(6):398-402

Department of Pediatrics, VM Medical College & Safdarjang Hospital, New Delhi, India.

Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of Langerhans cell histiocytosis, presenting at birth or in the neonatal period with cutaneous lesions that involute spontaneously. Affected infants are otherwise well with no systemic illness. A case of CSHLCH, probably the first case report from India, is described. Read More

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June 2004
3 Reads

Congenital self-healing reticulohistiocytosis: report of a case and review of the literature.

Acta Paediatr 2004 Mar;93(3):426-9

Department of Dermatology, Doctor Peset University Hospital, Valencia, Spain.

Unlabelled: Congenital self-healing reticulohistiocytosis (CSHRH), a rare disorder initially seen at birth or in the newborn period, is characterized by spontaneously involuting skin lesions. We present the case of a 12-d-old female who was born with many red-brownish nodules scattered over her entire body, and which regressed spontaneously.

Conclusion: Although there are no clues to differentiate CSHRH from Letterer-Siwe disease, some signs and symptoms might enable us to reach an accurate diagnosis. Read More

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March 2004
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Congenital self-healing reticulohistiocytosis mimicking diffuse neonatal hemangiomatosis.

Dermatology 2004 ;208(2):138-41

Departments of Dermatology and Pediatrics, Sin-Lau Christian Hospital, Tainan, Taiwan, ROC.

Congenital self-healing reticulohistiocytosis (CSRH), a rare benign variant of Langerhans cell histiocytosis (LCH), is characterized by (a). congenital skin lesions, (b). a healthy infant with no systemic involvement, (c). Read More

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http://dx.doi.org/10.1159/000076488DOI Listing
July 2004
22 Reads

An unusual presentation of congenital self-healing reticulohistiocytosis.

Br J Dermatol 2003 Jul;149(1):191-2

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, 7, Chung-Shan South Road, Taipei, Taiwan.

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July 2003
4 Reads

Congenital self-healing reticulohistiocytosis presenting with hemorrhagic bullae.

J Am Acad Dermatol 2003 May;48(5 Suppl):S75-7

Department of Dermatology at Shizuoka General Hospital, Japan.

Congenital self-healing reticulohistiocytosis is a variant of Langerhans cell histiocytosis. It is present at birth or appears in the neonatal period and involutes spontaneously within 3 to 4 months. Although the skin eruptions in most cases consist of papulonodules, several patients with vesicular or bullous lesions have been reported. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S019096220261550
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http://dx.doi.org/10.1067/mjd.2003.151DOI Listing
May 2003
4 Reads