Search our Database of Scientific Publications and Authors

I’m looking for a

    2881 results match your criteria Congenital Nevi

    1 OF 58

    Dermoscopic Findings of Scalp Aplasia Cutis Congenita.
    Skin Appendage Disord 2017 Jan 8;2(3-4):177-179. Epub 2016 Dec 8.
    Hair and Scalp Diseases, Outpatient Clinic, Division of Dermatology, Santa Casa de Misericórdia, Porto Alegre, Brazil.
    Aplasia cutis congenita (ACC) is a rare disease characterized by congenital absence of skin, affecting preferentially the scalp. Diagnosis is made clinically; however, recent studies have shown that dermoscopy can be a useful tool for the diagnosis and differentiation from sebaceous nevus. The clinical findings include a shiny atrophic alopecic patch associated with dermoscopic findings of absent follicular openings, thicker vessels and a distinct collar hypertrichosis. Read More

    Intense Pulsed Light Alone and in Combination with Erbium Yttrium-Aluminum-Garnet Laser on Small-to-Medium Sized Congenital Melanocytic Nevi: Single Center Experience Based on Retrospective Chart Review.
    Ann Dermatol 2017 Feb 3;29(1):39-47. Epub 2017 Feb 3.
    Department of Dermatology, Incheon St. Mary's Hospital, Incheon, Korea.
    Background: Treatment of congenital melanocytic nevi (CMN) with intense pulsed light (IPL) has recently produced promising results.

    Objective: To evaluate the clinical and histological outcomes of small-to-medium sized CMN treated with IPL alone and in combination with erbium: yttrium-aluminum-garnet (Er: YAG) laser.

    Methods: We performed a retrospective chart review of 26 small-to-medium sized CMN treated as described above. Read More

    Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi.
    Ann Dermatol 2017 Feb 3;29(1):26-32. Epub 2017 Feb 3.
    Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.
    Background: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma.

    Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Read More

    Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry.
    J Dtsch Dermatol Ges 2017 Feb;15(2):159-167
    Department of Dermatology, University of Lübeck, Germany.
    Background: Congenital melanocytic nevi (CMN) are associated with mental stress as well as medical risks for those affected. The German CMN registry was initiated in 2005. Herein, we present results from an interim analysis focusing on disease course, treatment modalities, and quality of life. Read More

    Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas.
    FP Essent 2017 Feb;453:33-37
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Congenital melanocytic nevi (CMN) are hamartomas present at birth that are composed of nevomelanocytes and thought to originate from faulty migration of precursor melanocytes in the neural crest. Classification is based on projected adult size of the lesion. CMN size correlates positively with risk of melanoma and neurocutaneous melanocytosis. Read More

    Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.
    BMJ Case Rep 2017 Feb 13;2017. Epub 2017 Feb 13.
    Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex, UK.
    Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. Read More

    Congenital Melanocytic Nevus Syndrome: A Case Series.
    Actas Dermosifiliogr 2017 Jan 19. Epub 2017 Jan 19.
    Servicio de Anatomía Patológica, Complejo Hospitalario de Toledo, Toledo, España.
    Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Read More

    Recurrent GNAQ mutations in anastomosing hemangiomas.
    Mod Pathol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Pathology, University of California, San Francisco, CA, USA.
    Anastomosing hemangiomas are recently described benign vascular lesions that occur chiefly in the genitourinary tract and paravertebral soft tissues. Owing to their rarity and unusual cytoarchitectural features, anastomosing hemangiomas are frequently confused with low-grade angiosarcomas. The specific genetic alterations underlying these lesions are currently unknown. Read More

    Melanoma in congenital melanocytic naevi.
    Br J Dermatol 2017 Jan 12. Epub 2017 Jan 12.
    Paediatric Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London.
    Congenital melanocytic naevi (CMN) are a known risk factor for melanoma, with the greatest risk currently thought to be in childhood. There has been controversy over the years about the incidence, and therefore over clinical management of CMN, due partly to the difficulties of histological diagnosis and partly to publishing bias towards cases of malignancy. Large cohort studies have demonstrated that risk in childhood is related to the severity of the congenital phenotype, not only cutaneous but neuroradiological. Read More

    Pathophysiology, diagnosis, and management of glaucoma associated with Sturge-Weber syndrome.
    Int Ophthalmol 2017 Jan 7. Epub 2017 Jan 7.
    Department of Ophthalmology, Allama Iqbal Medical College/Jinnah Hospital, Lahore, Pakistan.
    Purpose: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    Malignant Melanoma in Association With a Thymic Nevus in a Patient With a Giant Congenital Nevus.
    Am J Dermatopathol 2016 Dec 28. Epub 2016 Dec 28.
    *Institute of Pathology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; †Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; ‡Department of Oncology, Soroka Medical Center, Beer Sheva, Israel; §Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; ¶Institute of Pathology, Soroka Medical Center, Beer Sheva, Israel; and ‖Department of Cardiothoracic Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel.
    Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. Read More

    Complex Truncal Masses in the Setting of CLOVES Syndrome: Aesthetic and Functional Implications.
    Aesthetic Plast Surg 2016 Dec 28. Epub 2016 Dec 28.
    Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, 14th Floor South Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
    Background: Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal abnormalities (CLOVES) is a complex overgrowth syndrome with dramatic aesthetic and functional implications. The truncal masses characteristic of CLOVES syndrome are described as vascular malformations or lipomatous lesions with variable vascular components. Herein, we describe our single-institution experience with surgical excision of CLOVES-related truncal masses and discuss future directions in treatment of these complex anomalies. Read More

    Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years.
    J Obstet Gynaecol Res 2016 Dec 17. Epub 2016 Dec 17.
    Maternity and Perinatal Care Center, Hokkaido University Hospital, Sapporo, Japan.
    Aim: This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated.

    Methods: An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005-2009 (first) and 2010-2014 (second), respectively. Read More

    [Advance in research on congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2016 Dec;33(6):878-882
    Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
    Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) syndrome is a rare X-linked dominant and male-lethal multi-system disorder characterized by congenital hemidysplasia, strictly lateralized ichthyosiform nevus and ipsilateral limb defects. CHILD syndrome is caused by mutations of nicotinamide adenine dinucleotide phosphate steroid dehydrogenase-like protein (NSDHL) gene mapped to chromosome Xq28. The gene encodes 3β-hydroxylsterol dehydrogenase, which catalyses a step in the cholesterol biosynthetic pathway. Read More

    Pigmented oral compound nevus of retromolar area - A rare case report.
    Singapore Dent J 2016 Dec;37:33-35
    Department of Oral Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi. Electronic address:
    Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5. Read More

    The Relationship of Psoriasis and Melanocytic Nevi.
    Indian J Dermatol 2016 Nov-Dec;61(6):664-667
    Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.
    Background: There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi.

    Aims And Objectives: To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. Read More

    Tissue Expansion in Children.
    Semin Plast Surg 2016 Nov;30(4):155-161
    Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas.
    Tissue expansion is a well-established surgical method that has been creatively applied to the management of many congenital and acquired pediatric conditions, including the removal of giant congenital melanocytic nevi and the separation of conjoined twins. Careful preoperative planning and patient follow-up are required to achieve the proper results and minimize complications. Special considerations for pediatric patients are present during each step of the process, from patient selection to postoperative care. Read More

    An Overview of Pre-expanded Perforator Flaps: Part 2, Clinical Applications.
    Clin Plast Surg 2017 Jan;44(1):13-20
    Division of Plastic Surgery, University of California Davis Medical Center, 2221 Stockton Boulevard, Suite 2123, Sacramento, CA 95817, USA. Electronic address:
    Pre-expanded perforator flaps have several advantages over their traditional counterparts owing to the thin, more pliable nature, larger size, and minimum morbidity of the donor site. Recently, plastic surgeons have begun to use pre-expanded perforator flaps to reconstruct defects of almost the entire body, including the cervicofacial region, axilla, trunk, and extremities resulting from scar, congenital melanocytic nevi, hemangiomas, and neurofibromas. Such a versatile flap is especially appropriate for face and neck resurfacing, which requires more optimal functional and cosmetic outcomes. Read More

    Late-onset bulky naevocytoma of the perineum masquerading as a malignant melanoma.
    Clin Exp Dermatol 2017 Mar 15;42(2):178-181. Epub 2016 Nov 15.
    Department of Dermatology, VHS Medical Centre, Seoul, Korea.
    Bulky naevocytoma of the perineum is a very rare variant of giant congenital melanocytic naevus (GCMN). It presents as a bulky naevocytic tumour in the perineal region with characteristic histological findings, such as extensive areas with a neural appearance called 'lames foliacees', formation of a pseudofollicular structure and extension of naevus cells between collagen bundles in a row called 'Indian-file' pattern. We report a case of late-onset bulky naevocytoma of the perineum in a 13-year-old girl. Read More

    Giant melanocytic nevi with neurocutaneous melanosis masquerading as neurofibromas.
    J Pediatr Neurosci 2016 Jul-Sep;11(3):258-260
    Department of Neuroradiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Read More

    Reduced H3K27me3 Expression Is Common in Nodular Melanomas of Childhood Associated With Congenital Melanocytic Nevi But Not in Proliferative Nodules.
    Am J Surg Pathol 2017 Mar;41(3):396-404
    *Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY †Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH ‡Department of Dermatology, Northwestern University, Chicago, IL §Great Ormond Street Hospital for Children ∥UCL Institute of Child Health, London, UK.
    The formation of a nodule within a congenital melanocytic nevus (CMN) raises concerns about possible melanoma. Most new nodular growths that develop during childhood, however, are benign proliferative nodules (PN); melanoma is very rare. The distinction of melanoma from PN can at times be difficult clinically and histopathologically, requiring ancillary molecular tests for diagnosis. Read More

    Evaluating the Causes of Freckle and Nevus from the Viewpoint of Iranian Traditional Medicine.
    Iran J Med Sci 2016 May;41(3 Suppl):S67
    Department of Iranian Traditional Medicine' School of Medicine' Shiraz University of Medical Sciences' Shiraz' Iran.
    Background: Freckles are due to an increase in the amount of dark pigments called melanin. These spots are more likely developed on the sun-exposed skin areas like the cheeks, nose, and forehead. Nevus is usually a benign melanocytic tumor and can be congenital or acquired. Read More

    Diffuse Cavernous Hemangioma of the Colon.
    Acta Gastroenterol Belg 2016 Jul-Sep;79(3):393-394
    A 70-year-old man was admitted to our clinic with a history of rectal bleeding and constipation, his colonoscopy revealed varicosities and bluish nodular lesions of the rectum (Figure 1). Abdominal CT showed multiple nodular lesions beginning from the distal descending colon and extending to the rectum, calcifications suggesting phleboliths were also seen in these lesions. A contrast enhanced pelvic MRI demonstrated multiple tubular lesions showing hyperintensity on T2-weighted images and hypointensity on T1-weighted images, consistent with the affected areas on the CT scan (Figure 2). Read More

    Nevus spilus: is the presence of hair associated with an increased risk for melanoma?
    Cutis 2016 Sep;98(3):171-174
    Department of Dermatology, University of Mississippi Medical Center, Jackson, USA.
    Nevus spilus (NS), also known as speckled lentiginous nevus, is characterized by background café au lait-like lentiginous melanocytic hyperplasia speckled with small, 1- to 3-mm, darker foci. Nevus spilus occurs in 1.3% to 2. Read More

    Neurocutaneous Melanosis Presenting as Cavernous Hemangioma Persistent Abdominal Pain.
    J Craniofac Surg 2016 Oct 27. Epub 2016 Oct 27.
    *Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai †Department of Neurosurgery, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China.
    Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by the presence of multiple congenital melanocytic nevi and the proliferation of melanocytes in the central nervous system. The authors present a 9-year-old Chinese boy whose clinical manifestations are intermittent headache for 2 months and persistent abdominal pain for 10 days. 3D-reconstruction computed tomography angiography image, digital subtraction angiography, and magnetic resonance imaging plus angiography (MRI+MRA) examinations results suggested that cavernoma at left frontal lobe potentially associated with hemorrhage. Read More

    Total reconstruction of giant congenital circumferential nevi of the upper limb using a large pedicle expanded flank flap: A brief report.
    Ann R Coll Surg Engl 2016 Nov 22;98(8):e150-e151. Epub 2016 Sep 22.
    Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , UK.
    Tissue expansion is an invaluable reconstructive strategy after surgical excision of a congenital naevus. However, reducing the number of operations is very important for patients with a giant congenital naevus. We used a large pedicle expanded flank flap to successfully treat a giant circumferential naevus that extended from the left upper arm to the wrist, which also provided excellent contour and colour match. Read More

    Sclerotic Regressing Large Congenital Nevus.
    Pediatr Dermatol 2016 Nov 25;33(6):e366-e367. Epub 2016 Oct 25.
    Second Department of Dermatology, Faculty of Medicine, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
    Regression of congenital nevi is usually associated with loss of pigment or halo formation. In rare cases, regression is characterized by sclerosis and hair loss. We describe a rare case of a sclerotic hypopigmented large congenital melanocytic nevus in which a localized scleroderma-like reaction process of regression seemed to have started in utero and progressed throughout early childhood. Read More

    Abdominal vascular syndromes: characteristic imaging findings.
    Radiol Bras 2016 Jul-Aug;49(4):257-263
    Tenured Associate Professor in the Department of Diagnostic Imaging of the Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.
    Abdominal vascular syndromes are rare diseases. Although such syndromes vary widely in terms of symptoms and etiologies, certain imaging findings are characteristic. Depending on their etiology, they can be categorized as congenital-including blue rubber bleb nevus syndrome, Klippel-Trenaunay syndrome, and hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)-or compressive-including "nutcracker" syndrome, median arcuate ligament syndrome, Cockett syndrome (also known as May-Thurner syndrome), and superior mesenteric artery syndrome. Read More

    [Clinical and pathological analysis of ocular tumors in 504 children cases].
    Zhonghua Yan Ke Za Zhi 2016 Oct;52(10):764-768
    Tianjin Eye Hospital and Institute, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin 300020, China.
    Objective: To analyze the clinical features and pathological classification of chlidren's ocular tumors. Methods: Retrospective case series study. Five hundred and four cases (506 eyes) of ocular tumor with biopsy-proven in children below 14 years old between January 2002 and December 2014 from Tianjin Eye Hospital were performed to retrospectively investigated the lesion location, clinical features and histopathologic classification of these lesions. Read More

    [Indications of the expansion in pediatric surgery. Experience of 30years and literature review].
    Ann Chir Plast Esthet 2016 Oct 8;61(5):740-749. Epub 2016 Aug 8.
    Service de chirurgie plastique, esthétique et reconstructrice, hôpital Salengro, rue Émile-Laine, 59037 Lille cedex, France. Electronic address:
    The expansion of soft tissue, especially skin, is an old and physiological process to increase the skin reserve allowing excision while coveraging of the resulting loss of substance. Easy in principle, this process is subjected to constraints in children requiring precise planning and rigorous technical procedure. Between 1990 and 2016, we performed 293 expansion protocols with 411 implants in 244 children. Read More

    Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient.
    J Clin Neurosci 2016 Dec 8;34:232-234. Epub 2016 Oct 8.
    Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States. Electronic address:
    CLOVES (congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and scoliosis/skeletal/spinal anomalies) syndrome is a congenital and almost exclusively pediatric syndrome associated with vascular malformations of the neuroaxis. We report the case of a complex spinal arteriovenous fistula in an adult woman with CLOVES syndrome treated using a multidisciplinary approach with endovascular embolization and microsurgical technique, and review the medical literature on this disease. Read More

    Expanded bi-pedicled "sleeve" flap for reconstruction of the upper extremity after large circumferential nevus excision in children.
    J Plast Reconstr Aesthet Surg 2016 Dec 5;69(12):1676-1682. Epub 2016 Oct 5.
    Department of Plastic, Reconstructive, and Hand Surgery, Hadassah University Medical Center, Jerusalem, Israel.
    Background: Large congenital melanocytic nevi entail significant medical and cosmetic ramifications for patients and families. Reconstruction is a challenging endeavor, especially when the lesion is present on the limbs. The literature describes various methods by which a plastic surgeon can address reconstruction; yet, to date, there has been no series describing a method that provides consistent results with low complication rates. Read More

    Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma.
    Br J Dermatol 2016 Oct 8. Epub 2016 Oct 8.
    Departments of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida.
    Background And Objectives: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca(2+) channels (TTCs) are upregulated in human melanoma and play an important role on cell proliferation. The aim of this study was to describe for the first time in formalin-fixed-paraffin-embedded tissue the immunoexpression of TT-Cs in biopsies of normal skin, acquired melanocytic nevi and melanoma, in order to evaluate their role in melanomagenesis and/or tumor progression, their utility as prognostic markers and their possible use in targeted therapies. Read More

    [Congenital "kissing" lesions: Nevus or "café au lait" spot?]
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):433-437. Epub 2016 Oct 4.
    Service de chirurgie maxillo-faciale et plastique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Centre de référence des malformations faciales et de la cavité buccale, MAFACE, AP-HP, 75015 Paris, France; Université Paris Descartes, 75005 Paris, France. Electronic address:
    Introduction: "Café au lait" spots (CLS) are pigmented skin lesions principally located at the trunk and the limbs. Histologically, CLSs consist in an excessive pigmentation of the epidermis, with no risk of malignant transformation. The "kissing" nevus is a rare pigmented congenital nevus affecting both lower and upper eyelids in a mirror layout. Read More

    An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota.
    Cureus 2016 Jul 18;8(7):e698. Epub 2016 Jul 18.
    Medical Eye Associates, University of Central Florida College of Medicine.
    Melanomas arising from orbital melanocytic proliferations are exceedingly rare. Many questions remain regarding their development and malignant transformation. We report on a 45-year-old Caucasian woman with a nevus of Ota that presented with visual disturbances involving her right eye and was found to have a biopsy-proven cellular blue nevus in the orbital space. Read More

    An Extremely Rare Disorder of Somatic Mosaicism: CLOVES Syndrome.
    Adv Neonatal Care 2016 Oct;16(5):347-359
    Robert Wood Johnson Medical School, New Brunswick, New Jersey.
    Background: CLOVES (Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi Scoliosis, Skeletal, Spinal) syndrome is an extremely rare, complex, non-Mendelian genetic condition with clinical overlap to several other overgrowth syndromes.

    Purpose: This article shares an interesting case report of the prenatal to postnatal diagnostic course for an infant with this condition.

    Case Findings/results: It shares prenatal and postnatal images and imaging studies which helped confirm the diagnosis. Read More

    Multifocal vascular lesions.
    Semin Cutan Med Surg 2016 Sep;35(3):153-60
    Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York, USA.
    Multifocal vascular lesions are important to recognize and appropriately diagnose. Generally first noticed on the skin, multifocal vascular lesions may have systemic involvement. Distinguishing among the different types of multifocal vascular lesions is often based on clinical features; however, radiological imaging and/or biopsy are frequently needed to identify distinct features and guide treatment. Read More

    Genetic basis for vascular anomalies.
    Semin Cutan Med Surg 2016 Sep;35(3):128-36
    Johns Hopkins School of Medicine, Department of Dermatology, Baltimore, Maryland, USA.
    The fundamental genetics of many isolated vascular anomalies and syndromes associated with vascular anomalies have been elucidated. The rate of discovery continues to increase, expanding our understanding of the underlying interconnected molecular pathways. This review summarizes genetic and clinical information on the following diagnoses: capillary malformation, venous malformation, lymphatic malformation, arteriovenous malformation, PIK3CA-related overgrowth spectrum (PROS), Proteus syndrome, SOLAMEN syndrome, Sturge-Weber syndrome, phakomatosis pigmentovascularis, congenital hemangioma, verrucous venous malformation, cutaneomucosal venous malformation, blue rubber bleb nevus syndrome, capillary malformation-arteriovenous malformation syndrome, Parkes-Weber syndrome, and Maffucci syndrome. Read More

    Melanoma associated with congenital intermediate common blue nevus of the scalp - Case report.
    An Bras Dermatol 2016 Jul-Aug;91(4):514-6
    Hospital Federal de Bonsucesso - Rio de Janeiro (RJ), Brazil.
    Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater frequency, as in the case described. Read More

    Prepubertal Melanoma Arising within a Medium-Sized Congenital Melanocytic Nevus.
    Pediatr Dermatol 2016 Nov 30;33(6):e372-e374. Epub 2016 Aug 30.
    Division of Dermatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
    We report the case of an 8-year-old child who developed a 9.4-mm-deep melanoma within a medium-sized congenital melanocytic nevus on the scalp. Genetic analysis revealed an activating NRAS Q61R mutation within the melanoma, which is more commonly associated with large or giant congenital melanocytic nevi. Read More

    Spontaneous Regression of a Congenital Melanocytic Nevus by Sclerosis.
    Pediatr Dermatol 2016 Nov 30;33(6):e368-e371. Epub 2016 Aug 30.
    Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    Congenital melanocytic nevi (CMNs) naturally evolve throughout life, growing proportionately with the child, darkening, and exhibiting textural or surface changes (e.g., papillomatous, verrucous, cerebriform), hypertrichosis, and, later in life, lightening of pigmentation. Read More

    Melanocytic Nevi in Children: A Review.
    Pediatr Ann 2016 Aug;45(8):e293-8
    Common moles on the skin, known scientifically as melanocytic nevi, are seen frequently in the pediatric population. They are broadly grouped into two groups: congenital (generally present at birth or in infancy) or acquired. Congenital melanocytic nevi (CMN) are classified based on size and morphologic features. Read More

    1 OF 58