3,118 results match your criteria Congenital Nevi


Serial Excision for the Treatment of Giant Congenital Melanocytic Nevus: The Vietnamese Way.

Open Access Maced J Med Sci 2019 Jan 26;7(2):231-233. Epub 2019 Jan 26.

University of Rome G. Marconi, Rome, Italy.

Aim: To investigate the efficacy of plastic surgery in the treatment of giant congenital melanocytic nevus (GCMN).

Methods: We enrolled 20 patients with 44 lesions and performed one of the following procedures: serial excision, skin grafting, tissue expansion, primary skin closure, distant flap, and adjacent flap. We assessed the outcome at 10 days and 6 months after surgery. Read More

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http://dx.doi.org/10.3889/oamjms.2019.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364729PMC
January 2019

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
February 2019
1 Read

Pluripotency markers are differentially induced by IGF1 and bFGF in cells from patients' lesions of large/giant congenital melanocytic nevi.

Biomark Res 2019 14;7. Epub 2019 Jan 14.

Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.

Factors regulating transcription of pluripotency genes in congenital nevo-melanocytes are not known. Nevo-melanocytes belong somewhere in-between the ends of a spectrum where the normal epidermal melanocyte represents one end and a melanoma cell with multiple genetic abnormalities represents the other. Cells from large/giant congenital nevi (L/GCMN), unlike normal melanocytes, grow colonies on soft agar and express pluripotency markers, similar to melanoma cells. Read More

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http://dx.doi.org/10.1186/s40364-018-0152-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332894PMC
January 2019
1 Read

Congenital nevi with hypomelanosis and fine scales.

Eur J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo.

Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed.

Objectives: To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Read More

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http://dx.doi.org/10.1684/ejd.2018.3496DOI Listing
January 2019

Overgrowth syndrome in neonates: a rare case series with a review of the literature.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

We present here two-term neonates presenting with right lower limb hypertrophy, a port-wine stain, acral abnormalities and clubfeet. These neonates had overlapping features of Klippel Trenaunay syndrome and congenital lipomatous overgrowth, vascular malformation, epidermal nevi and scoliosis/skeletal abnormalities. Such overgrowth syndrome has not been previously described in the literature. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22564
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http://dx.doi.org/10.1136/bcr-2018-225640DOI Listing
January 2019
2 Reads

Effect of Size and Location of Nevi on Postoperative Pain and Emergence Agitation in Children Undergoing Nevi Excision.

J Clin Med 2019 Jan 17;8(1). Epub 2019 Jan 17.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon 164, Korea.

Congenital melanocytic nevi need surgical excisions. However, the effect of the size and location of the nevi on pain and emergence agitation have yet to be studied. The objective of this study was to evaluate (1) the ideal parameter of the nevus size and (2) the effects of the size and location of the nevus on pain and emergence agitation. Read More

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http://www.mdpi.com/2077-0383/8/1/106
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http://dx.doi.org/10.3390/jcm8010106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352197PMC
January 2019
2 Reads

Common Neonatal Skin Lesions: Melanocytic Nevi, Pigment Alterations, and Nonmelanocytic Nevi.

Pediatr Ann 2019 Jan;48(1):e23-e29

Birthmarks are common in the healthy population and are generally harmless. Certain presentations, however, raise concern for associated syndromes or potential complications. It is important for pediatricians to be familiar with both harmless and potentially concerning birthmarks. Read More

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http://dx.doi.org/10.3928/19382359-20181207-01DOI Listing
January 2019

Connexin43 mutations linked to skin disease have augmented hemichannel activity.

Sci Rep 2019 Jan 10;9(1):19. Epub 2019 Jan 10.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, 11794, USA.

Mutations in the gene (GJA1) encoding connexin43 (Cx43) are responsible for several rare genetic disorders, including non-syndromic skin-limited diseases. Here we used two different functional expression systems to characterize three Cx43 mutations linked to palmoplantar keratoderma and congenital alopecia-1, erythrokeratodermia variabilis et progressiva, or inflammatory linear verrucous epidermal nevus. In HeLa cells and Xenopus oocytes, we show that Cx43-G8V, Cx43-A44V and Cx43-E227D all formed functional gap junction channels with the same efficiency as wild-type Cx43, with normal voltage gating and a unitary conductance of ~110 pS. Read More

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http://www.nature.com/articles/s41598-018-37221-2
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http://dx.doi.org/10.1038/s41598-018-37221-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328547PMC
January 2019
5 Reads

Coccygeal Polypoid Eccrine Nevus.

Arch Pathol Lab Med 2018 Dec 28. Epub 2018 Dec 28.

From the Department of Pathology (Dr Charifa) and the Department of Dermatology (Dr Ko), Yale School of Medicine, New Haven, Connecticut.

Skin tags are fairly common lesions usually seen in adults on the neck and in body folds. The sacrococcygeal region is an unusual location for skin tags in children and may represent a congenital malformation of the spine or an isolated skin lesion. In this review, we summarize the clinical presentation, histopathologic changes, and differential diagnosis of coccygeal polypoid eccrine nevus as a rare cause of sacrococcygeal papules in children. Read More

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http://dx.doi.org/10.5858/arpa.2018-0055-RSDOI Listing
December 2018
2.838 Impact Factor

Use of Targeted Next-Generation Sequencing to Identify Activating Hot Spot Mutations in Cherry Angiomas.

JAMA Dermatol 2019 Jan 2. Epub 2019 Jan 2.

Department of Dermatology, Massachusetts General Hospital, Boston.

Importance: Shared gene variants in benign-malignant process pairs, such as BRAF mutations common to benign nevi and melanoma, are associated with differing phenotypic manifestations. Study of gene mechanisms underlying cherry angioma may uncover previously unknown disease relationships.

Objective: To identify somatic mutations present in cherry angioma specimens by using targeted next-generation sequencing. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.4231DOI Listing
January 2019
4 Reads

Lethal melanoma in a two-year-old child with multiple congenital melanocytic nevi.

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):89-93

Department of Dermatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_938_17DOI Listing
December 2018
2 Reads

Detection of a multilineage mosaic NRAS mutation c.181C>A (p.Gln61Lys) in an individual with a complex congenital nevus syndrome.

Pigment Cell Melanoma Res 2018 Dec 7. Epub 2018 Dec 7.

Institute of Human Genetics, University Hospital Otto-von-Guericke-University, Magdeburg, Germany.

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http://dx.doi.org/10.1111/pcmr.12761DOI Listing
December 2018
1 Read

Giant congenital facial melanocytic nevus.

Oman J Ophthalmol 2018 Sep-Dec;11(3):265-266

Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Giant Congenital Melanocytic Nevus (GCMNs) is mostly reported in area of trunk followed by limbs and head. Their incidence is <1:20,000 newborns It derives attention due to its association with malignant melanoma.The risk of developing malignant melanoma is between 5 to 10%. Read More

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http://dx.doi.org/10.4103/ojo.OJO_216_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219340PMC
December 2018
9 Reads

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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http://dx.doi.org/10.1177/0009922818816421DOI Listing
December 2018
2 Reads

Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases.

Actas Dermosifiliogr 2018 Oct 25. Epub 2018 Oct 25.

Centro Integral de Dermatología, Tucumán, Argentina.

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http://dx.doi.org/10.1016/j.ad.2018.03.023DOI Listing
October 2018
1 Read

Genetic variant in the NSDHL gene in a cat with multiple congenital lesions resembling inflammatory linear verrucous epidermal nevi.

Vet Dermatol 2019 Feb 25;30(1):64-e18. Epub 2018 Nov 25.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Länggassstrasse 120, 3001, Bern, Switzerland.

Background: The feline counterpart of human inflammatory linear verrucous epidermal nevus (ILVEN) has been described; however, the possible underlying developmental defect has not been investigated.

Objective: To report a case of multiple ILVEN-like lesions in a cat with a genetic variant in the NSDHL gene.

Animals: A 2-year-old, female, domestic short hair cat with a history of multiple alopecic, verrucous, hyperpigmented and erythematous skin lesions, following Blaschko's lines on the head, the limbs, the trunk and paw pads. Read More

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http://dx.doi.org/10.1111/vde.12699DOI Listing
February 2019
6 Reads

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins.

J Curr Glaucoma Pract 2018 May-Aug;12(2):94-98. Epub 2018 Aug 1.

Senior Resident, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Aim: To report a case of bilateral phacomatosis pigmentovascularis (PPV), in a young male,presenting with developmental glaucoma and high myopia along with systemic features of klippel trenanauy weber (KTW) syndrome.

Background: The co-existence of oculodermal melanocytosis (ODM)and port-wine stain was termed PPV by Ota. Port-wine stain presents as part of Sturge-Weber syndrome (SWS). Read More

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http://www.jaypeejournals.com/eJournals/ShowText.aspx?ID=147
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http://dx.doi.org/10.5005/jp-journals-10008-1251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236123PMC
August 2018
10 Reads

Proliferating Neurocristic Hamartoma Arising in a Giant Congenital Nevus: Comparative Genomic Hybridization Findings.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Deramatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.

Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001319DOI Listing
November 2018
1 Read

Not lost to follow-up: A rare case of CHILD syndrome in a boy reappears.

JAAD Case Rep 2018 Nov 9;4(10):1010-1013. Epub 2018 Nov 9.

Department of Dermatology, the University of California, Irvine, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232698PMC
November 2018
5 Reads

Functional Subunit Reconstruction of Giant Facial Congenital Melanocytic Nevi in Children With the Use of Matriderm and Skin Graft: Surgical Experience and Literature Review.

Eplasty 2018 5;18:e30. Epub 2018 Oct 5.

Plastic and Reconstructive Surgery Section, Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Facial giant congenital melanocytic nevus represents a major cosmetic deformity for the child and parents and is a challenge for the plastic surgeons to achieve best cosmetic results. Herein, we present a case of single-stage surgical reconstruction using partial-thickness scalp skin graft aided with Matriderm dermal substitute for a facial giant congenital melanocytic nevus. An 8-year-old boy presented with a facial giant congenital melanocytic nevus without leptomeningeal involvement. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232950PMC
October 2018
10 Reads

Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.

Cureus 2018 Sep 10;10(9):e3275. Epub 2018 Sep 10.

Radiotherapy, Christian Medical College, Vellore, IND.

Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. Read More

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http://dx.doi.org/10.7759/cureus.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235644PMC
September 2018
4 Reads

Concurrent Congenital Fibrolipomatous Hamartoma and Congenital Nevus of Infancy: A Syndromic or Chance Association.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):219-221

Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital nevi and fibrolipomatous hamartoma are benign tumors of childhood, the latter being very uncommon. Fibrous hamartoma of infancy typically occurs in <2 years of life. The concurrence of these two lesions is extremely rare. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_163_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182949PMC
November 2018
3 Reads

Comment on "Proportionate growth of congenital nevi: Blow a balloon to explain".

Pediatr Dermatol 2018 Nov;35(6):877

Division of Dermatology, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

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http://doi.wiley.com/10.1111/pde.13672
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http://dx.doi.org/10.1111/pde.13672DOI Listing
November 2018
8 Reads

Comment on "Proportionate growth of congenital nevi: Blow a balloon to explain".

Pediatr Dermatol 2018 Nov;35(6):878

Faculty of Dermatology, College of medicine, King Faisal University, Al Ahsa, Saudi Arabia.

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http://doi.wiley.com/10.1111/pde.13662
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http://dx.doi.org/10.1111/pde.13662DOI Listing
November 2018
9 Reads

Primary Congenital Trichorrhexis Nodosa with Nevus Achromicus: A Rare Presentation.

Int J Trichology 2018 Jul-Aug;10(4):186-188

Department of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

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http://dx.doi.org/10.4103/ijt.ijt_7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192233PMC
November 2018

Universal ocular screening of 481 infants using wide-field digital imaging system.

BMC Ophthalmol 2018 Oct 30;18(1):283. Epub 2018 Oct 30.

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, 1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.

Background: Universal ocular screening of infants is not a standard procedure in children's health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system.

Methods: Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208088PMC
October 2018
15 Reads

Comparison of treatment options for small to medium congenital melanocytic nevi: A retrospective review of 119 cases.

Lasers Surg Med 2019 Jan 30;51(1):62-67. Epub 2018 Oct 30.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Objectives: For small to medium sized congenital melanocytic nevi (CMN), the treatment of choice is staged surgical excision. Ablative lasers or pigment-specific lasers have also been recommended for lesions difficult for surgical removal or to avoid surgery. In this study, we retrospectively analyzed the results of several treatment options for CMN to find out the optimal treatment method. Read More

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http://doi.wiley.com/10.1002/lsm.23030
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http://dx.doi.org/10.1002/lsm.23030DOI Listing
January 2019
5 Reads

Genetic Abnormalities in Large to Giant Congenital Nevi: Beyond NRAS Mutations.

J Invest Dermatol 2018 Oct 22. Epub 2018 Oct 22.

Melanoma Unit, Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain; Department of Biochemical and Molecular Genetics, Hospital Clínic, IDIBAPS, University of Barcelona, Catalonia, Spain.

Large and giant congenital melanocytic nevi (CMN) are rare melanocytic lesions mostly caused by postzygotic NRAS alteration. Molecular characterization is usually focused on NRAS and BRAF genes in a unique biopsy sample of the CMN. However, large/giant CMN may exhibit phenotypic differences among distinct areas, and patients differ in features such as presence of multiple CMN or spilus-like lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183268
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http://dx.doi.org/10.1016/j.jid.2018.07.045DOI Listing
October 2018
9 Reads

Sedation for screening MRI in patients with congenital melanocytic naevi under the age of one is a successful, safe and economical first-line approach.

Br J Dermatol 2018 Oct 3. Epub 2018 Oct 3.

Department of Paediatric Dermatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, U.K.

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http://doi.wiley.com/10.1111/bjd.17263
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http://dx.doi.org/10.1111/bjd.17263DOI Listing
October 2018
3 Reads

A neurofibroma-like tumor in a giant congenital nevus.

J Dtsch Dermatol Ges 2018 Dec 1;16(12):1507-1510. Epub 2018 Oct 1.

Department of Dermatology and Allergic Diseases, University Medical Center Ulm, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13676
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http://dx.doi.org/10.1111/ddg.13676DOI Listing
December 2018
1 Read

Efficacy of Cultured Epithelial Autograft after Curettage for Giant Melanocytic Nevus of the Head.

Plast Reconstr Surg Glob Open 2018 Jun 19;6(6):e1827. Epub 2018 Jun 19.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata, Japan.

Cultured epithelial autograft (CEA) is an epithelial sheet prepared from a patient's own skin using cell culture. In Japan, CEA (JACE; Japan Tissue Engineering Co., Ltd. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157934PMC
June 2018
13 Reads

Appearance of Verruca Over Linear Verrucous Epidermal Nevus - An Example of Locus Minoris Resistentiae: A Report of Three Cases.

Indian Dermatol Online J 2018 Sep-Oct;9(5):334-337

Department of Pathology, JSS Medical College and Hospital, JSS University, Mysuru, Karnataka, India.

Locus minoris resistentiae (LMR) is a site of the body that offers lesser resistance than the rest of the body to the onset of disease. It can be congenital or acquired. Areas of cutaneous mosaicism such as epidermal nevi can act as congenital LMR, leading to the development of inflammatory skin conditions or skin tumors on these. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_337_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137671PMC
September 2018
4 Reads

Long-term outcomes of laser treatment for congenital melanocytic nevi.

J Am Acad Dermatol 2019 Feb 15;80(2):523-531.e12. Epub 2018 Sep 15.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Background: Although various laser treatments have been tried for congenital melanocytic nevi (CMNs), only small retrospective studies with short-term follow-up had been done to assess outcomes.

Objective: We analyzed the long-term outcomes of laser treatment for CMN and compared these outcomes with those of a combination treatment including partial excision and lasers.

Methods: Patients with CMN treated with lasers were retrospectively reviewed, and patients with >3 years of follow-up were grouped as the long-term follow-up group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183251
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http://dx.doi.org/10.1016/j.jaad.2018.08.046DOI Listing
February 2019
2 Reads

Shunt Surgery for Neurocutaneous Melanosis with Hydrocephalus: Case Report and Review of the Literature.

World Neurosurg 2018 Dec 8;120:583-589.e3. Epub 2018 Sep 8.

Section of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines. Electronic address:

Background: Neurocutaneous melanosis is a rare phakomatosis characterized by large or multiple pigmented nevi and melanosis of the leptomeninges. It is often complicated by hydrocephalus due to melanotic deposits interfering with cerebrospinal fluid reabsorption in the basal cisterns or causing foraminal or aqueductal obstruction. In 10% of cases, it will be associated with the Dandy-Walker complex. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.002DOI Listing
December 2018
9 Reads

Dermatoscopy of Common Lesions in Pediatric Dermatology.

Dermatol Clin 2018 Oct 16;36(4):463-472. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via S. Sofia 78, Catania 95123, Italy.

The use of dermatoscopy to assist in the diagnosis of a variety of proliferative, pigmentary, inflammatory, infectious, congenital, and genetic cutaneous and skin appendage disorders is constantly increasing, as it is effective, affordable, noninvasive, and quick to perform. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183108
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http://dx.doi.org/10.1016/j.det.2018.05.012DOI Listing
October 2018
16 Reads
1.434 Impact Factor

Facial nevus depigmentosus getting remarkable repigmentation by treatment with a 308-nm excimer laser: A case report.

Dermatol Ther 2018 09 10;31(5):e12662. Epub 2018 Sep 10.

Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Nevus depigmentosus (ND) is a rare, congenital, nonprogressive depigmented lesion with irregular outline. To date, the few therapeutic approaches that have been developed to treat ND have yielded unsatisfactory results. We reported on a 6-month-old girl who presented with a ND on the right side of her face for 5 months. Read More

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http://dx.doi.org/10.1111/dth.12662DOI Listing
September 2018
1 Read

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.

Virchows Arch 2019 Jan 6;474(1):111-115. Epub 2018 Sep 6.

Department of Dermatology, Unit of Pediatric Dermatology - CHRU Tours, Tours, France.

Cutaneous spindle-cell neoplasms in adults as well as children represent a frequent dilemma for pathologists. Along this neoplasm spectrum, the differential diagnosis with CD34-positive proliferations can be challenging, particularly concerning neoplasms of fibrohistiocytic and fibroblastic lineages. In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1007/s00428-018-2415-0DOI Listing
January 2019
14 Reads
2.651 Impact Factor

A female infant with phacomatosis pigmentovascularis and congenital chylous ascites: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e12012

Department of Urology Surgery, Beijing Children's Hospital, National Center for Children's Health.

Rationale: Phacomatosis pigmentovascularis (PPV) is a rare syndrome characterized by capillary malformation and pigmentary nevus. Congenital chylous ascites (CCA) is also a rare disease that results from maldevelopment of the lymphatic system. We report a case of a 5-month-old girl, who had both PPV and CCA. Read More

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http://dx.doi.org/10.1097/MD.0000000000012012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112933PMC
August 2018
3 Reads

New insights into neurocutaneous melanosis.

Pediatr Radiol 2018 11 3;48(12):1786-1796. Epub 2018 Aug 3.

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Ave., San Francisco, CA, 94143-0628, USA.

Background: Neurocutaneous melanosis is a rare disorder in which children with large cutaneous melanotic nevi have associated melanosis in the brain. Although many affected children have structurally normal brains, some have associated developmental disorders or brain anomalies.

Objectives: To determine the range of extent of brain melanosis as assessed by magnetic resonance imaging (MRI) and to investigate the frequency and types of associated brain anomalies. Read More

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http://dx.doi.org/10.1007/s00247-018-4205-xDOI Listing
November 2018
3 Reads

An update on molecular alterations in melanocytic tumors with emphasis on Spitzoid lesions.

Ann Transl Med 2018 Jun;6(12):249

First Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Significant progress in the molecular pathology of melanocytic tumors have revealed that benign neoplasms, so-called nevi, are initiated by gain-of-function mutations in one of several primary oncogenes, such as in acquired melanocytic nevi, in congenital nevi or / in blue nevi, with consequent MAPK and PI3K/AKT/mTOR activation. Secondary genetic alterations overcome tumor suppressive mechanisms and allow the progression to intermediate lesions characterized by TERT-p mutation or to invasive melanomas displaying disruption of tumor suppressor genes. Currently, melanoma is molecularly regarded as four different diseases, namely , , and the "triple wild type" subtypes, which are associated with particular clinicopathological features. Read More

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http://atm.amegroups.com/article/view/20068/19956
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http://dx.doi.org/10.21037/atm.2018.05.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046302PMC
June 2018
21 Reads

Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus.

Mol Med Rep 2018 Sep 31;18(3):3153-3158. Epub 2018 Jul 31.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Keratosis pilaris (KP) and nevus comedonicus (NC) are congenital keratinized dermatoses; however, the exact etiology of these two diseases is unclear. The objective of the present study was to identify the disease‑causing genes and their association with functional alterations in the development of KP and NC. Peripheral blood samples of one KP family, two NC families and 100 unrelated healthy controls were collected. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2018.9342
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http://dx.doi.org/10.3892/mmr.2018.9342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102636PMC
September 2018
7 Reads

Congenital fibroblastic connective tissue nevi: Unusual and misleading presentations in three infantile cases.

Pediatr Dermatol 2018 Sep 19;35(5):644-650. Epub 2018 Jul 19.

Services de Chirurgie Maxillo-Faciale et Plastique, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants-Malades, Université Sorbonne Paris Cité, Université Paris Descartes, Paris, France.

Background: Fibroblastic connective tissue nevi (FCTN) are benign skin conditions characterized by bland spindle cells infiltrating the reticular dermis and the upper subcutis with preservation of adnexal structures. A subset of FCTN expresses CD34, which may cause difficulties in the differential diagnosis, in particular with dermatofibrosarcoma (DFSP). We aim to study clinical and histological main features of congenital FCTN to better understand their heterogeneity. Read More

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http://dx.doi.org/10.1111/pde.13571DOI Listing
September 2018
4 Reads

Spectrum of Clinical, Neuroimaging, and Cerebrospinal Fluid Features of Adult Neurocutaneous Melanocytosis.

Eur Neurol 2018 13;80(1-2):1-6. Epub 2018 Jul 13.

Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing,

Background: Neurocutaneous melanocytosis (NCM) is a poorly understood disease due to its rarity. This study aimed to summarize the characteristics of adult NCM and improve the awareness of this disease.

Methods: The clinical data of 13 adult patients with NCM were retrospectively reviewed, including neuroimages, cerebrospinal fluid (CSF), and histological features. Read More

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http://dx.doi.org/10.1159/000488687DOI Listing
January 2019
19 Reads

Port-wine stain as a clue for two rare coexisting entities.

BMJ Case Rep 2018 Jul 13;2018. Epub 2018 Jul 13.

Department of Dermatovenereology, Hospital de Braga, Braga, Portugal.

Phakomatosis pigmentovascularis (PPV) is an uncommon dermatosis characterised by the presence of both pigmentary and vascular abnormalities. Its pathogenesis is not elucidated, and the prognosis is mainly determined by the presence of extracutaneous manifestations, such as Klippel-Trenaunay syndrome (KTS), that is defined by the triad of a port-wine stain (PWS), anomalous veins and progressive overgrowth of the affected extremity. Herein, we report a case of an adult patient, who presented with a large PWS, nevus of Ota, ocular melanosis, and limb hypertrophy and varicosities. Read More

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http://dx.doi.org/10.1136/bcr-2018-225721DOI Listing
July 2018
3 Reads

Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS and BRAF mutation-negative nodules.

Pediatr Dermatol 2018 Sep 12;35(5):e281-e285. Epub 2018 Jul 12.

Faculty of Medicine, University of Oslo, Oslo, Norway.

We report the case of a newborn boy with multinodular NRAS and BRAF mutation-negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age. Read More

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http://dx.doi.org/10.1111/pde.13595DOI Listing
September 2018
10 Reads