1,311 results match your criteria Congenital Heart Disease[Journal]


Accuracy of risk prediction scores in pregnant women with congenital heart disease.

Congenit Heart Dis 2019 Feb 6. Epub 2019 Feb 6.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine Philadelphia, Pennsylvania.

Objective: To assess performance of risk stratification schemes in predicting adverse cardiac outcomes in pregnant women with congenital heart disease (CHD) and to compare these schemes to clinical factors alone.

Design: Single-center retrospective study.

Setting: Tertiary care academic hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12750DOI Listing
February 2019
2 Reads

Strategy of treating secundum atrial septal defect not referred to percutaneous closure.

Congenit Heart Dis 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, P.R. China.

Objective: To evaluate safety and effectiveness of intraoperative device closure for secundum atrial septal defect (ASD) not referred to percutaneous closure.

Design And Patients: From April 2010 to December 2018, 231 secundum ASD children (≤14 years) directly recommended to surgical repair were enrolled in this study. These patients were divided into two groups according to the parents' choice based on surgeons' recommendation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12753DOI Listing
February 2019
2 Reads

Education as important predictor for successful employment in adults with congenital heart disease worldwide.

Congenit Heart Dis 2019 Feb 4. Epub 2019 Feb 4.

Amsterdam UMC, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.

Background: Conflicting results have been reported regarding employment status and work ability in adults with congenital heart disease (CHD). Since this is an important determinant for quality of life, we assessed this in a large international adult CHD cohort.

Methods: Data from 4028 adults with CHD (53% women) from 15 different countries were collected by a uniform survey in the cross-sectional APPROACH International Study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12747DOI Listing
February 2019
1 Read

Two-year evolution of latent rheumatic heart disease in Malawi.

Congenit Heart Dis 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, Baylor College of Medicine Clinical Center of Excellence, Lilongwe, Malawi.

Background: In asymptomatic children, screening echocardiography has been used to attempt to diagnose rheumatic heart disease (RHD) at an early stage (latent RHD). World Heart Federation guidelines have standardized categorization of "definite," "borderline," or no RHD by echo findings. The progression of RHD diagnosed through echo screening is not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12756DOI Listing
January 2019
1 Read

Obesity trends in children, adolescents, and young adults with congenital heart disease.

Congenit Heart Dis 2019 Jan 30. Epub 2019 Jan 30.

Cleveland Clinic Children's, Cleveland, Ohio.

Objectives: To determine the prevalence, age of onset, and risk factors for overweight and obesity in children with congenital heart disease (CHD).

Study Design: Children with CHD who were seen at our institution from 1996 to 2017 were studied. Patients were full-time residents of the United States and were receiving all cardiac care at our institution. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12754
Publisher Site
http://dx.doi.org/10.1111/chd.12754DOI Listing
January 2019
5 Reads

Systolic/diastolic ratio correlates with end diastolic pressures in pediatric patients with single right ventricles.

Congenit Heart Dis 2019 Jan 30. Epub 2019 Jan 30.

Pediatric Cardiology, Lucille Packard Children's Hospital, Palo Alto, California.

Background: Increased ventricular end-diastolic pressure (VEDP) is a known risk factor for morbidity and mortality in patients with single right ventricle (RV) physiology. Previous studies have shown mixed results correlating echocardiographic measurements with catheter-derived VEDP in this population. Goal of this study was to evaluate if echocardiographic systolic/diastolic ratio (S/D) correlated with VEDP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12755DOI Listing
January 2019

Opportunities for training to advance the care for adults with congenital heart disease with advanced circulatory failure.

Congenit Heart Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatrics, Section of Pediatric and Adult Congenital Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

Heart failure is an emerging issue with important implications in adult patients with congenital heart disease. Practitioners with expertise in both adult congenital heart disease and heart failure are needed to manage this growing and often complex population. In the United States, the optimal training pathway to enable practitioners to best care for these patients is ill-defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12748DOI Listing
January 2019

Safety of contraceptive use among women with congenital heart disease: A systematic review.

Congenit Heart Dis 2019 Jan 25. Epub 2019 Jan 25.

Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.

Objective: Women with congenital heart disease (CHD) are at increased risk of pregnancy complications and need information on safe, effective contraceptive methods to avoid unintended pregnancy. This systematic review examines evidence regarding safety of contraceptive use among women with CHD.

Methods: The PubMed database was searched for any peer-reviewed articles published through April 2018 that included safety outcomes associated with reversible contraceptive methods among women with CHD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12752DOI Listing
January 2019
1 Read

Body mass index in adults with congenital heart disease.

Congenit Heart Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium.

Objective: To investigate the status of body mass index (BMI) in adult people with congenital heart disease (ACHD).

Methods: Five hundred thirty-nine adults with CHD (53.8% men) were seen in the outpatient clinic from 2013 to 2015 and compared to a reference population (n = 1737). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12751DOI Listing
January 2019
1 Read

A better approach for left ventricular training in transposition of the great arteries and intact interventricular septum: Bidirectional cavopulmonary anastomosis and pulmonary artery banding.

Congenit Heart Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatric Cardiology, Florence Nightingale Hospital, Istanbul, Turkey.

Objective: Management of the patients with transposition of the great arteries and intact ventricular septum may be challenging beyond the newborn period. Herein, we would like to present our alternative strategy for training the left ventricle in these patients.

Methods: Six patients with transposition of the great arteries and intact ventricular septum were evaluated in our clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12749DOI Listing
January 2019

Creatinine-based estimation of glomerular filtration rate in patients with a Fontan circulation.

Congenit Heart Dis 2019 Jan 21. Epub 2019 Jan 21.

Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.

Background: Patients with a Fontan circulation are at risk of renal dysfunction. We analyzed cross-sectional data in pediatric and adult Fontan patients in order to assess the accuracy of commonly used serum creatinine-based methods in estimating glomerular filtration rate (GFR).

Methods: A total of 124 Fontan patients (58 children, 66 adults) were enrolled across three study centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12746DOI Listing
January 2019
2 Reads

Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta.

Congenit Heart Dis 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.

Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.

Hypothesis: Biomarker levels at coarctation repair will predict persistent left ventricular remodeling at 1-year follow up. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12744
Publisher Site
http://dx.doi.org/10.1111/chd.12744DOI Listing
January 2019
7 Reads

Feeding methods for infants with single ventricle physiology are associated with length of stay during stage 2 surgery hospitalization.

Congenit Heart Dis 2019 Jan 12. Epub 2019 Jan 12.

Department of Pediatrics, Otolaryngology, Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Tube feedings are often needed to achieve the growth and nutrition goals associated with decreased morbidity and mortality in patients with single ventricle anatomy. Variability in feeding method through the interstage period has been previously described, however, comparable information following stage 2 palliation is lacking.

Objectives: To identify types of feeding methods following stage 2 palliation and their influence on length of stay. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12742
Publisher Site
http://dx.doi.org/10.1111/chd.12742DOI Listing
January 2019
11 Reads

Pulmonary artery interventions after the arterial switch operation: Unique and significant risks.

Congenit Heart Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatric Cardiology, Rady Children's Hospital, University of California San Diego, San Diego, California.

Background: In the modern era, results of the arterial switch operation (ASO) for transposition of the great arteries are excellent. However, because of the LeCompte maneuver, there may be a propensity for development of pulmonary artery stenosis. We encountered atypical complications of pulmonary artery stenting in patients after the ASO, including aorto-pulmonary fistula and coronary compression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12726DOI Listing
January 2019
1 Read

Extended cardiac ambulatory rhythm monitoring in adults with congenital heart disease: Arrhythmia detection and impact of extended monitoring.

Congenit Heart Dis 2019 Jan 3. Epub 2019 Jan 3.

Department of Pediatrics, Division of Cardiology, Stanford University School of Medicine, Lucile Packard Children's Hospital, Stanford, California.

Background: Arrhythmias are a leading cause of death in adults with congenital heart disease (ACHD). While 24-48-hour monitors are often used to assess arrhythmia burden, extended continuous ambulatory rhythm monitors (ECAM) can record 2 weeks of data. The utility of this device and the arrhythmia burden identified beyond 48-hour monitoring have not been evaluated in the ACHD population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12736DOI Listing
January 2019
1 Read

Variation in care practices across pediatric acute care cardiology units: Results of the Pediatric Acute Care Cardiology Collaborative (PAC ) hospital survey.

Congenit Heart Dis 2019 Jan 3. Epub 2019 Jan 3.

UCSF Benioff Children's Hospital, Department of Pediatrics, UCSF School of Medicine, San Francisco, California.

Background: The Pediatric Acute Care Cardiology Collaborative (PAC ) was established in 2014 to improve the quality, value, and experience of hospital-based cardiac acute care outside of the intensive care unit. An initial PAC project was a comprehensive survey to understand unit structure, practices, and resource utilization across the collaborative. This report aims to describe the previously unknown degree of practice variation across member institutions. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12739
Publisher Site
http://dx.doi.org/10.1111/chd.12739DOI Listing
January 2019
2 Reads

S100B and its relation to cerebral oxygenation in neonates and infants undergoing surgery for congenital heart disease.

Congenit Heart Dis 2019 Jan 3. Epub 2019 Jan 3.

Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.

Objectives: Neonates and infants undergoing surgery for congenital heart disease are at risk for developmental impairment. Hypoxic-ischemic brain injury might be one contributing factor. We aimed to investigate the perioperative release of the astrocyte protein S100B and its relation to cerebral oxygenation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12741DOI Listing
January 2019
1 Read

Small unrepaired atrial septal defects display impaired exercise capacity compared with healthy peers.

Congenit Heart Dis 2018 Dec 24. Epub 2018 Dec 24.

Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.

Objective: Adult patients with small, unrepaired atrial septal defects have an increased risk of pneumonia, atrial fibrillation, and stroke. Furthermore, they have higher late mortality than the background population. The functional capacity is unknown in these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12740DOI Listing
December 2018
2 Reads

Perspectives on advance care planning and palliative care among adults with congenital heart disease.

Congenit Heart Dis 2018 Dec 21. Epub 2018 Dec 21.

Cambia Palliative Care Center of Excellence, University of Washington, Seattle, Washington.

Background: Patients with adult congenital heart disease (ACHD) report that advance care planning (ACP) is important, and that they want information about prognosis. However, recognizing importance and being willing to participate are different constructs, and how and when to begin ACP and palliative care discussions remains ill-defined.

Methods: We conducted a cross-sectional survey of 150 consecutive outpatients to assess willingness to participate in ACP, with whom, and important barriers and facilitators to these discussions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12735DOI Listing
December 2018
1 Read

New intriguing subsets of pediatric hyperlipidemia patients.

Authors:

Congenit Heart Dis 2018 Nov;13(6):883

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12734DOI Listing
November 2018
1 Read

Focal liver lesions following Fontan palliation of single ventricle physiology: A radiology-pathology case series.

Congenit Heart Dis 2018 Dec 20. Epub 2018 Dec 20.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Purpose: Patients who have undergone Fontan palliation of single ventricle physiology congenital heart disease are prone to developing focal liver lesions. In our experience, the variety of lesions occurring in this population is greater than that described in the literature. The purpose of this study was to describe the breadth of biopsy-proven liver lesions in patients post-Fontan palliation of single ventricle physiology cared for at our institution. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12730
Publisher Site
http://dx.doi.org/10.1111/chd.12730DOI Listing
December 2018
9 Reads

Percutaneous closure of perimembranous ventricular septal defects utilizing almost ideal Amplatzer Duct Occluder II: Why limitation in sizes?

Congenit Heart Dis 2018 Dec 18. Epub 2018 Dec 18.

Pediatric Heart Center of Hessen, Goethe University, Frankfurt am Main, Germany.

Aim: The purpose of this study is to describe the special aspects of perimembranous ventricular septal defects (pmVSD) closure by utilizing Amplatzer Duct Occluder II (ADO II) devices with a rational request for bigger ADO-II sizes, based on our experience in transcatheter device closure of pmVSD.

Methods And Results: At our institution, placement of an ADO II device was used in 15 patients with pmVSD; the patients' age ranged between 6 months and 20 years. The indications for closure were CHF (n = 4), hemodynamically significant shunt (n = 7), tricuspid regurgitation (n = 3), and high risk for infective endocarditis (n = 2), respectively. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12731
Publisher Site
http://dx.doi.org/10.1111/chd.12731DOI Listing
December 2018
7 Reads

Racial disparities in clinic follow-up early in life among survivors of congenital heart disease.

Congenit Heart Dis 2018 Dec 18. Epub 2018 Dec 18.

Center for Innovation in Pediatric Practice, Nationwide Children's Hospital, Columbus, Ohio.

Objective: The current study aims to identify the rates of lapses in care and loss to follow-up before age one through age five for white and nonwhite congenital heart disease (CHD) survivors. Nonwhite CHD survivors were hypothesized to experience an earlier lapse in care and be lost to follow-up than whites.

Design: Patients were from a large pediatric hospital and had (1) at least one outpatient cardiology clinic visit or cardiac surgery visit before the age of one and (2) a diagnosis of moderate or complex structural CHD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12732DOI Listing
December 2018
1 Read

Prevalence of Noonan spectrum disorders in a pediatric population with valvar pulmonary stenosis.

Congenit Heart Dis 2018 Dec 16. Epub 2018 Dec 16.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.

Design: A retrospective chart review of 204 patients diagnosed with vPS between 9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of Noonan syndrome were collected. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/chd.12721
Publisher Site
http://dx.doi.org/10.1111/chd.12721DOI Listing
December 2018
11 Reads

Leaflet morphology classification of the Melody Transcatheter Pulmonary Valve.

Congenit Heart Dis 2018 Dec 13. Epub 2018 Dec 13.

The Heart Center, Nationwide Children's Hospital, Columbus, Ohio.

Objective: We sought to describe the leaflet morphology variation in the Melody Transcatheter Pulmonary Valve (TPV) and evaluate associated outcomes. The Melody TPV is constructed from harvested bovine jugular venous valves which have been rigorously tested. Natural anatomic leaflet variations are seen in the Melody TPV but have not been evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12728DOI Listing
December 2018
4 Reads

What is a hemodynamically significant PDA in preterm infants?

Congenit Heart Dis 2018 Dec 12. Epub 2018 Dec 12.

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.

Objective: There is no consensus on the definition of a hemodynamically significant patent ductus arteriosus (hsPDA). In this review article, our objective is to discuss the main variables that one should consider when determining the hemodynamic significance of a PDA.

Results: We describe the various approaches that have been utilized over time to define an hsPDA and discuss the strengths and weaknesses of each echocardiographic index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12727DOI Listing
December 2018
1 Read

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12715DOI Listing
December 2018
4 Reads

State of the art-Patent ductus arteriosus.

Authors:

Congenit Heart Dis 2018 Sep;13(5):645

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/chd.12689
Publisher Site
http://dx.doi.org/10.1111/chd.12689DOI Listing
September 2018
10 Reads

From the Chair of the AAP Section on Cardiology & Cardiac Surgery.

Authors:

Congenit Heart Dis 2018 Sep;13(5):877-878

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12697DOI Listing
September 2018
3 Reads

The effect of right ventricular function on survival and morbidity following stage 2 palliation: An analysis of the single ventricle reconstruction trial public data set.

Congenit Heart Dis 2018 Dec 2. Epub 2018 Dec 2.

Division of Cardiology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia.

Objective: Limited information is known on how right ventricular function affects outcomes after stage 2 palliation. We evaluated the impact of different right ventricular indices prior to stage 2 palliation on morbidity and mortality.

Design: Retrospective study design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12722DOI Listing
December 2018
3 Reads

Burnout and work-life balance among pediatric cardiologists: A single center experience.

Congenit Heart Dis 2018 Dec 2. Epub 2018 Dec 2.

Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Background: Physicians are exposed to workplace factors that may result in acute or chronic stress resulting in burnout. This may impact the productivity and result in suboptimal patient care practices.

Methods: We surveyed pediatric cardiology attending physicians at our institution to assess their perception of burnout and work-life balance using the Maslach Burnout Inventory and the Areas of Work-Life Survey. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12723
Publisher Site
http://dx.doi.org/10.1111/chd.12723DOI Listing
December 2018
7 Reads

Fetal hemodymanic effects on ductus arteriosus development and influences on postnatal management in infants with ductal-dependent pulmonary blood flow.

Authors:
Anthony Merlocco

Congenit Heart Dis 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, Department of Pediatrics, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee.

The ductus arteriosus (DA) has been studied since Galen. Initially after birth in neonates with obstruction to pulmonary blood flow, DA patency is integral to ensure output and oxygenation. While DA stenting dates back 25 years, there is emerging interest in better understanding how and when to utilize this strategy as an alternative to surgical shunt placement or ongoing prostaglandin administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12719DOI Listing
December 2018
5 Reads

Dysrhythmias in patients with a complete atrioventricular septal defect: From surgery to early adulthood.

Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: Outcomes after surgical repair of complete atrioventricular septal defect (cAVSD) have improved. With advancing age, the risk of development of dysrhythmias may increase. The aims of this study were to (1) examine development of sinus node dysfunction (SND), atrial and ventricular tachyarrhythmias, and (2) study progression of atrioventricular conduction abnormalities in young adult patients with repaired cAVSD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12724DOI Listing
November 2018
3 Reads

The relationship between serum apelin levels and aortic dilatation in bicuspid aortic valve patients.

Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiology, Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey.

Objective: The bicuspid aortic valve (BAV) is the most common congenital heart disease. The process of aortic dilatation is not completely clear in patients with the BAV. Apelin is a peptide found at high levels in vascular endothelial cells which has a role in vascular regulation and cardiovascular function. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12718
Publisher Site
http://dx.doi.org/10.1111/chd.12718DOI Listing
November 2018
10 Reads

Pediatric dysautonomia: Much-maligned, often overmedicated, but not as complex as you think.

Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.

Division of Pediatric Cardiology, Department of Pediatrics, East Carolina University Brody School of Medicine, Greenville, North Carolina.

Dysautonomia is an increasingly recognized yet still poorly understood disease within the field of pediatrics. Symptoms, including dizziness, headaches, fatigue, joint pain, anxiety, and intolerance of heat or cold, are often significant and difficult to sort, especially in terms of their relation to each other. This often leads to referral to multiple subspecialists, who then proceed to treat seemingly familiar symptoms in kind. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12720
Publisher Site
http://dx.doi.org/10.1111/chd.12720DOI Listing
November 2018
8 Reads

Molecular and mechanical factors contributing to ductus arteriosus patency and closure.

Congenit Heart Dis 2018 Nov 23. Epub 2018 Nov 23.

Mildred T. Stahlman Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12714
Publisher Site
http://dx.doi.org/10.1111/chd.12714DOI Listing
November 2018
3 Reads

The long-term functional outcome in Mustard patients study: Another decade of follow-up.

Congenit Heart Dis 2018 Nov 23. Epub 2018 Nov 23.

Pediatric Cardiology, Riley Hospital for Children, Indianapolis, Indiana.

Objective: For over 20 years, we have followed a cohort of patients who underwent the Mustard procedure for d-transposition of the great arteries. The current study follows the same cohort from our last study in 2007 to reassess their functional capacity and quality of life.

Participants: Of the original 45 patients, six patients have required cardiac transplant and 10 patients have died, including two of the transplanted patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12698DOI Listing
November 2018
7 Reads

Historical investigation of medical treatment for adult congenital heart disease: A Canadian perspective.

Congenit Heart Dis 2018 Nov 19. Epub 2018 Nov 19.

Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Objective: The number of adults with congenital heart disease (CHD) has increased substantially because of medical advances that are extending life expectancy beyond childhood. A historical investigation is timely not only because of this significant demographic shift, but also because stakeholder engagement is increasingly important in shaping research directions. The study questions were: From the perspective of stakeholders, what is known about the medical treatment for the adult CHD cohort in Canada and how has it changed over time?

Design/methods: We harnessed the use of historical research methods and conducted interviews with 21 key informants in order to articulate a contextualized understanding of the evolution of adult CHD treatment in Canada. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12716
Publisher Site
http://dx.doi.org/10.1111/chd.12716DOI Listing
November 2018
9 Reads

Vasopressor magnitude predicts poor outcome in adults with congenital heart disease after cardiac surgery.

Congenit Heart Dis 2018 Nov 19. Epub 2018 Nov 19.

Division of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.

Background: High levels of vasoactive inotrope support (VIS) after congenital heart surgery are predictive of morbidity in pediatric patients. We sought to discern if this relationship applies to adults with congenital heart disease (ACHD).

Methods: We retrospectively studied adult patients (≥18 years old) admitted to the intensive care unit after cardiac surgery for congenital heart disease from 2002 to 2013 at Mayo Clinic. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12717
Publisher Site
http://dx.doi.org/10.1111/chd.12717DOI Listing
November 2018
6 Reads
1.202 Impact Factor

Predictors and rates of recurrence of atrial arrhythmias following catheter ablation in adults with congenital heart disease.

Congenit Heart Dis 2018 Nov 19. Epub 2018 Nov 19.

Division of Cardiology, Department of Medicine, Schneeweiss Adult Congenital Heart Center, Columbia University Medical Center, New York, New York.

Background: Catheter ablation is commonly performed to treat atrial arrhythmias in adult congenital heart disease (ACHD). Despite the frequency of ablations in the ACHD population, predictors of recurrence remain poorly defined.

Objective: We sought to determine predictors of arrhythmia recurrence in ACHD patients following catheter ablation for atrial arrhythmias. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12695DOI Listing
November 2018
2 Reads

Prenatal heart block screening in mothers with SSA/SSB autoantibodies: Targeted screening protocol is a cost-effective strategy.

Congenit Heart Dis 2018 Nov 16. Epub 2018 Nov 16.

Children's Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: Maternal anti-Ro/SSA and anti-La/SSB antibodies can lead to fetal complete heart block (CHB). Current guidelines recommend weekly echocardiographic screening between 16 and 28 weeks gestation. Given the cost of screening and the rarity of conduction abnormalities in fetuses of mothers with low anti-Ro levels (<50 U/mL), we sought to identify a strategy that optimizes resource utilization. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12713
Publisher Site
http://dx.doi.org/10.1111/chd.12713DOI Listing
November 2018
12 Reads

Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease.

Congenit Heart Dis 2018 Nov 5. Epub 2018 Nov 5.

Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California.

Background: We previously described the association of genetic variants in calcium channel genes and susceptibility to Kawasaki disease (KD), an acute, self-limited vasculitis, and the most common cause of acquired cardiac disease in children. Abnormal repolarization of cardiomyocytes and changes in T wave morphology have been reported in KD but have not been studied systematically.

Methods: We analyzed acute and convalescent ECG T wave morphology in two independent cohorts of KD subjects and studied the association between bifid T waves and genetic variants in previously reported genes with SNVs associated with cardiac repolarization. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12696
Publisher Site
http://dx.doi.org/10.1111/chd.12696DOI Listing
November 2018
7 Reads

Diastolic velocity half time is associated with aortic coarctation gradient at catheterization independent of echocardiographic and clinical blood pressure gradients.

Congenit Heart Dis 2018 Sep 5;13(5):713-720. Epub 2018 Nov 5.

Department of Pediatric Cardiology, Mount Sinai Hospital, New York, New York.

Objective: The most accurate noninvasive parameter to predict whether a patient with aortic coarctation will meet interventional criteria at catheterization remains elusive. We aim to determine the best independent echocardiographic predictors of a coarctation peak-to-peak pressure gradient ≥20 mm Hg at catheterization, the accepted threshold for intervention.

Design: Retrospective query of our catheterization database from 1/2007 to 7/2016 for the diagnostic code of aortic coarctation was performed. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12637
Publisher Site
http://dx.doi.org/10.1111/chd.12637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289687PMC
September 2018
13 Reads

A restrictive ventilatory pattern is common in patients with univentricular heart after Fontan palliation and associated with a reduced exercise capacity and quality of life.

Congenit Heart Dis 2018 Oct 30. Epub 2018 Oct 30.

Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technical University of Munich, München, Germany.

Aim: The Fontan circulation is highly dependent on ventilation, improving pulmonary blood flow and cardiac output. A reduced ventilatory function is reported in these patients. The extent of this impairment and its relation to exercise capacity and quality of life is unknown and objective of this study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12694
Publisher Site
http://dx.doi.org/10.1111/chd.12694DOI Listing
October 2018
22 Reads

The utility of cardiac magnetic resonance imaging in post-Fontan surveillance.

Congenit Heart Dis 2018 Oct 30. Epub 2018 Oct 30.

Emory University School of Medicine, Atlanta, Georgia.

Objective: Gated cardiac MRI offers the most detailed and accurate noninvasive method of assessing cardiac anatomy, particularly in patients with complex congenital heart disease. The proposed benefits of using cMRI as a routine screening tool in the Fontan population include early recognition of asymptomatic, postoperative anatomic and physiologic changes. In 2011, we therefore instituted at our center a recommended practice of cMRI screening in patients with Fontan physiology at 3 and 8 years post-Fontan operation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/chd.12692DOI Listing
October 2018
4 Reads

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease.

Congenit Heart Dis 2018 Oct 23. Epub 2018 Oct 23.

Division of Adult Congenital Heart Disease Pathophysiology and Lifelong Care, Tokyo Women's Medical University, Tokyo, Japan.

Objective: The recognition of fluid retention is critical in treating heart failure (HF). Bioelectrical impedance analysis (BIA) is a well-known noninvasive method; however, data on its role in managing patients with congenital heart disease (CHD) are limited. Here, we aimed to clarify the correlation between BIA and HF severity as well as the prognostic value of BIA in adult patients with CHD. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12683
Publisher Site
http://dx.doi.org/10.1111/chd.12683DOI Listing
October 2018
10 Reads

Application of pediatric Appropriate Use Criteria for initial outpatient evaluation of asymptomatic patients with abnormal electrocardiograms.

Congenit Heart Dis 2018 Oct 23. Epub 2018 Oct 23.

Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Introduction: In the pediatric Appropriate Use Criteria (AUC), abnormal electrocardiogram (ECG) in an asymptomatic patient has been rated as an "Appropriate" indication for transthoracic echocardiogram (TTE). We hypothesized that the yield of abnormal findings on TTE for this indication will be low.

Methods: All asymptomatic patients (≤ 18 years) from January 1, 2015 to December 31, 2017 who underwent initial outpatient evaluation at our center and had a TTE ordered for an abnormal ECG, were included. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12687
Publisher Site
http://dx.doi.org/10.1111/chd.12687DOI Listing
October 2018
7 Reads

Phosphodiesterase type 5 inhibitors improve microvascular dysfunction markers in pulmonary arterial hypertension associated with congenital heart disease.

Congenit Heart Dis 2018 Oct 20. Epub 2018 Oct 20.

Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: Ideally, vasodilator therapies for pulmonary arterial hypertension (PAH) should have a favorable impact on markers of vascular dysfunction, in addition to their known effects on hemodynamics, cardiac function, and patient's physical capacity.

Methods: We analyzed circulating (plasma) markers of endothelial and platelet activation/dysfunction (enzyme-linked immunoassays) in the specific setting of advanced PAH associated with congenital heart disease, during the course of sildenafil and tadalafil therapies. Thirty-one patients were enrolled (age 10-54 years), most of them with chronic hypoxemia and elevated hematocrit. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12688
Publisher Site
http://dx.doi.org/10.1111/chd.12688DOI Listing
October 2018
17 Reads

Frontiers in Fontan failure: Innovation and improving outcomes: A conference summary.

Congenit Heart Dis 2018 Oct 20. Epub 2018 Oct 20.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

The initial "Frontiers in Fontan Failure" conference in 2015 in Atlanta, GA, provided an opportunity for experts in the field of pediatric cardiology and adult congenital heart disease to focus on the etiology, physiology, and potential interventions for patients with "Failing Fontan" physiology. Four types of "Fontan Failure" were described and then published by Dr Book et al. The acknowledgment that even Dr Fontan himself realized that the Fontan procedure "imposed a gradually declining functional capacity and premature late death after an initial period of often excellent palliation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12685
Publisher Site
http://dx.doi.org/10.1111/chd.12685DOI Listing
October 2018
17 Reads

Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia.

Congenit Heart Dis 2018 Oct 20. Epub 2018 Oct 20.

Division of Neonatology and Le Bonheur Children's Hospital, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12691
Publisher Site
http://dx.doi.org/10.1111/chd.12691DOI Listing
October 2018
14 Reads