1,702 results match your criteria Congenital Diaphragmatic Hernia Imaging


3D reconstruction of diaphragmatic defects in CDH: a fetal MRI study.

Ultrasound Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objectives: To assess the clinical feasibility and validity of fetal MRI-based 3D reconstructions to localize, classify, and quantify diaphragmatic defects in congenital diaphragmatic hernia (CDH).

Methods: Manual segmentation of the diaphragm based on 65 in vivo and four postmortem fetal MRI scans of 46 CDH cases (gestational age 16 - 38 gestational weeks (GW)) was performed using SSFP, T2-weighted, and T1-weighted sequences and ITK-Snap. The resultant 3D models of the fetal diaphragm and its defect(s) were validated by postmortem MRI segmentation in four cases and/or comparison to a reference classification based on autopsy and surgery reports. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20296
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http://dx.doi.org/10.1002/uog.20296DOI Listing
April 2019
2 Reads

Postnatal ultrasonography for evaluation of hernia sac of neonate with congenital diaphragmatic hernia.

Radiol Case Rep 2019 Jun 26;14(6):683-686. Epub 2019 Mar 26.

Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Congenital diaphragmatic hernia (CDH) is one of the most common major congenital anomalies. The presence of a hernia sac is associated with additional benefits in terms of improved neonatal survival. Here, we report a case of CDH with a hernia sac detected via postnatal ultrasonography. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439226PMC
June 2019
1 Read

Group B streptococcal sepsis and congenital diaphragmatic hernia: do not overlook normal initial imaging studies!

Arch Dis Child Fetal Neonatal Ed 2019 Mar 29. Epub 2019 Mar 29.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/archdischild-2018-316667DOI Listing
March 2019
1 Read

Heterogeneous Pulmonary Response After Tracheal Occlusion: Clues to Fetal Lung Growth.

J Surg Res 2019 Mar 8;239:242-252. Epub 2019 Mar 8.

Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Background: Understanding inconsistent clinical outcomes in infants with severe congenital diaphragmatic hernia (CDH) after tracheal occlusion (TO) is a crucial step for advancing neonatal care. The objective of this study is to explore the heterogeneous airspace morphometry and the metabolic landscape changes in fetal lungs after TO.

Methods: Fetal lungs on days 1 and 4 after TO were examined using mass spectrometry-based metabolomics, fluorescence lifetime imaging microscopy (FLIM), the number of airspaces, and tissue-to-airspace ratio (TAR). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.015DOI Listing
March 2019
3 Reads

Prenatal prediction of survival in congenital diaphragmatic hernia: An audit of postnatal outcomes.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric General and Thoracic Surgery, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

Purpose: Effective antenatal counseling in congenital diaphragmatic hernia (CDH) relies on proper measurement of prognostic indices. This quality initiative audited the accuracy of prenatal imaging with postnatal outcomes at two tertiary pediatric referral centers.

Methods: Prenatal lung-head ratio (LHR) and total fetal lung volume (TFLV) for CDH patients treated between 2006 and 2017 were retrieved. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468193005
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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.021DOI Listing
January 2019
3 Reads

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 5. Epub 2019 Jan 5.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Belgium; Clinical Department of Obstetrics & Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health, University College London, London, UK; European Reference Network on Rare and Inherited Congenital Anomalies "ERNICA". Electronic address:

Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension (PHT), that is lethal in up to 32% of patients. In isolated cases, the outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.010DOI Listing
January 2019
4 Reads

Liver heterotopia associated with congenital diaphragmatic hernia: Two case reports and a review of the literature.

Medicine (Baltimore) 2019 Jan;98(4):e14211

Division of Pediatric Surgery, Department of Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Rationale: Liver heterotopia associated with congenital diaphragmatic hernia (CDH) is a rare condition; to the best of our knowledge, only 17 cases have been reported to date. The histogenesis and clinicopathological features are largely unknown. We herein report 2 cases of liver heterotopia associated with CDH along with 17 cases described in the literature to shed light on their clinicopathological characteristics. Read More

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http://dx.doi.org/10.1097/MD.0000000000014211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358339PMC
January 2019
5 Reads

Variable phenotypic expression of Apert syndrome in monozygotic twins.

Clin Case Rep 2019 Jan 11;7(1):54-57. Epub 2018 Nov 11.

Department of Gynecology and Obstetrics CHRU de Nancy Nancy France.

Apert syndrome in monozygotic twins can lead to different phenotypic expression of the disease in the two fetuses. Apert syndrome can be associated with congenital left diaphragmatic hernia and cleft palate. Read More

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http://dx.doi.org/10.1002/ccr3.1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333066PMC
January 2019
7 Reads

Perinatal diagnosis and management of early-onset Marfan syndrome: case report and systematic review.

J Matern Fetal Neonatal Med 2019 Jan 17:1-12. Epub 2019 Jan 17.

a Hospital General Universitario Gregorio Marañón , Madrid , Spain.

Early onset Marfan syndrome is the most severe form of Marfan syndrome diagnosed during perinatal period. Early onset Marfan syndrome is associated with high mortality rates, usually within the first 2 years of life. First, we present a case of prenatally diagnosed early onset Marfan syndrome in a dichorionic diamniotic twin pregnancy, where suspicion was raised at 35 weeks of gestation. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1552935DOI Listing
January 2019
15 Reads

Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes.

Pediatr Radiol 2019 May 11;49(5):593-599. Epub 2019 Jan 11.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The presence of a hernia sac in congenital diaphragmatic hernia (CDH) has been reported to be associated with higher lung volumes and better postnatal outcomes.

Objective: To compare prenatal imaging (ultrasound and MRI) prognostic measurements and postnatal outcomes of CDH with and without hernia sac.

Materials And Methods: We performed database searches from January 2008 to March 2017 for surgically proven cases of CDH with and without hernia sac. Read More

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http://dx.doi.org/10.1007/s00247-018-04334-9DOI Listing
May 2019
3 Reads

A Multimodality Navigation System for Endoscopic Fetal Surgery: A Phantom Case Study for Congenital Diaphragmatic Hernia.

Surg Innov 2019 Feb 28;26(1):27-36. Epub 2018 Nov 28.

2 King's College Hospital, Fetal Medicine Research Institute, London, UK.

This article presents a multi-modality tracking and navigation system achieved by merging optical tracking and ultrasound imaging into a novel navigation software to help in surgical pre-planning and real-time target setting and guidance. Fetal surgeries require extensive experience in coordination of hand-eye-ultrasound-surgical equipment, knowledge, and precise assessment of relative anatomy. While there are navigation systems available for similar constrained working spaces in arthroscopic and cardiovascular procedures, fetal minimally invasive surgery does not yet have a dedicated navigation platform capable of supporting robotic instruments that can be adapted to the set of unique procedures. Read More

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http://dx.doi.org/10.1177/1553350618813244DOI Listing
February 2019
8 Reads

Imaging of thoracic hernias: types and complications.

Insights Imaging 2018 Dec 27;9(6):989-1005. Epub 2018 Nov 27.

Imaging Science, University of Rochester Medical Center, 601, Elmwood Avenue, Rochester, NY, 14642, USA.

Thoracic hernias are characterised by either protrusion of the thoracic contents outside their normal anatomical confines or extension of the abdominal contents within the thorax. Thoracic hernias can be either congenital or acquired in aetiology. They can occur at the level of the thoracic inlet, chest wall or diaphragm. Read More

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http://dx.doi.org/10.1007/s13244-018-0670-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269341PMC
December 2018
8 Reads

A new approach to risk stratification using fetal MRI to predict outcomes in congenital diaphragmatic hernia: the preliminary retrospective single institutional study.

Transl Pediatr 2018 Oct;7(4):356-361

Department of Obstetrics, Perinatal Medical Center, Kobe Children's Hospital, Kobe, Japan.

Background: Congenital diaphragmatic hernia (CDH) is a condition with a wide range of severity. Prenatal diagnosis is essential to optimize postnatal management, especially for severe cases. The lung to head ratio (LHR) and liver herniation estimated by prenatal ultrasound has been used as prenatal predictors in CDH. Read More

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http://dx.doi.org/10.21037/tp.2018.09.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212392PMC
October 2018
18 Reads

Segmentation and classification in MRI and US fetal imaging: Recent trends and future prospects.

Med Image Anal 2019 01 19;51:61-88. Epub 2018 Oct 19.

BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; ICREA, Barcelona, Spain.

Fetal imaging is a burgeoning topic. New advancements in both magnetic resonance imaging and (3D) ultrasound currently allow doctors to diagnose fetal structural abnormalities such as those involved in twin-to-twin transfusion syndrome, gestational diabetes mellitus, pulmonary sequestration and hypoplasia, congenital heart disease, diaphragmatic hernia, ventriculomegaly, etc. Considering the continued breakthroughs in utero image analysis and (3D) reconstruction models, it is now possible to gain more insight into the ongoing development of the fetus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13618415183084
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http://dx.doi.org/10.1016/j.media.2018.10.003DOI Listing
January 2019
16 Reads

99mTc-MAG3 Renography of Intrathoracic Renal Ectopia.

Clin Nucl Med 2019 Jan;44(1):78-80

Urology, Reinier de Graaf Hospital, Delft, the Netherlands.

We report a case of a 49-year-old woman with a rare anomaly, intrathoracic renal ectopia. Her medical history includes a surgically corrected congenital diaphragmatic hernia, which can cause late presentations of diaphragmatic hernia in adult life. The Tc-MAG3 renogram demonstrated slower emptying of the dilated pelvis of the ectopic kidney than the normal kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002336DOI Listing
January 2019
15 Reads

Comparison of Laparoscopic Versus Open Surgical Management of Morgagni Hernia.

Ann Thorac Surg 2019 Jan 6;107(1):257-261. Epub 2018 Oct 6.

Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Morgagni hernias are rare congenital diaphragmatic hernias that often do not become clinically significant until adulthood. The purpose of this study was to characterize the preoperative findings and describe surgical outcomes of Morgagni hernia repair based on operative approach.

Methods: Charts of patients who underwent repair of a Morgagni hernia were retrospectively reviewed from 1987 to 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183136
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http://dx.doi.org/10.1016/j.athoracsur.2018.08.021DOI Listing
January 2019
2 Reads

Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia.

Pediatr Radiol 2019 02 6;49(2):217-223. Epub 2018 Oct 6.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Many infants with congenital diaphragmatic hernia (CDH) show brain abnormality on postnatal brain MRI related to severity of CDH, degree of lung hypoplasia, intrathoracic liver, right diaphragmatic hernia and large diaphragmatic defect. It is not known whether these factors affect brain growth in utero in CDH.

Objective: To assess prenatal brain morphometry and abnormalities on fetal MR in congenital diaphragmatic hernia. Read More

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http://link.springer.com/10.1007/s00247-018-4272-z
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http://dx.doi.org/10.1007/s00247-018-4272-zDOI Listing
February 2019
12 Reads

Surgery for Cushing's disease in pregnancy: our experience and a literature review.

Ann R Coll Surg Engl 2019 Jan 5;101(1):e26-e31. Epub 2018 Oct 5.

Department of Endocrinology, University Hospital Birmingham , Birmingham , UK.

Cushing's syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing's disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing's syndrome in pregnancy is often delayed due to overlap of symptoms. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303815PMC
January 2019
18 Reads

Prognostic utility of noninvasive estimates of pulmonary vascular compliance in neonates with congenital diaphragmatic hernia.

J Pediatr Surg 2019 Mar 9;54(3):439-444. Epub 2018 Sep 9.

Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201. Electronic address:

Aim: To evaluate echocardiographic indices of pulmonary vascular resistance and right ventricular (RV) function in predicting death or ECMO in congenital diaphragmatic hernia (CDH).

Methods: In this single center study, early (<48 h) echocardiograms of neonates with CDH (n = 47) were reviewed by a single reader for the ratio of tricuspid regurgitant velocity to velocity time integral at the pulmonary valve (TRV/VTIpv), TRV2/VTIpv, RV fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE). Receiver operating characteristic curves were generated for each parameter to obtain optimal cutoff values. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468183056
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http://dx.doi.org/10.1016/j.jpedsurg.2018.08.057DOI Listing
March 2019
3 Reads

Quantitative Assessment of Regional Dynamic Airway Collapse in Neonates via Retrospectively Respiratory-Gated H Ultrashort Echo Time MRI.

J Magn Reson Imaging 2019 Mar 25;49(3):659-667. Epub 2018 Sep 25.

Upper Airway Center, Division of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.

Background: Neonatal dynamic tracheal collapse (tracheomalacia, TM) is a common and serious comorbidity in infants, particularly those with chronic lung disease of prematurity (bronchopulmonary dysplasia, BPD) or congenital airway or lung-related conditions such as congenital diaphragmatic hernia (CDH), but the underlying pathology, impact on clinical outcomes, and response to therapy are not well understood. There is a pressing clinical need for an accurate, objective, and safe assessment of neonatal TM.

Purpose: To use retrospectively respiratory-gated ultrashort echo-time (UTE) MRI to noninvasively analyze moving tracheal anatomy for regional, quantitative evaluation of dynamic airway collapse in quiet-breathing, nonsedated neonates. Read More

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http://dx.doi.org/10.1002/jmri.26296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375762PMC
March 2019
14 Reads

Secondary Imaging Findings Aid in Prenatal Diagnosis and Characterization of Congenital Diaphragmatic Hernia: Role of an Abnormal Orientation of Vascular Structures and Gallbladder Position.

J Ultrasound Med 2018 Sep 23. Epub 2018 Sep 23.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objectives: To determine whether an abnormal orientation of the abdominal or hepatic vasculature and an abnormal gallbladder position on prenatal ultrasound (US) imaging are associated with intrathoracic liver herniation and postnatal outcomes in cases of congenital diaphragmatic hernia (CDH).

Methods: Children who underwent prenatal US examinations and postnatal CDH repair at our institution were eligible. Prenatal US images were reviewed, and the orientation of the superior mesenteric artery (SMA) and hepatic veins as well as gallbladder position were recorded. Read More

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http://dx.doi.org/10.1002/jum.14823DOI Listing
September 2018
4 Reads

Early Postnatal Ventricular Dysfunction Is Associated with Disease Severity in Patients with Congenital Diaphragmatic Hernia.

J Pediatr 2018 12 6;203:400-407.e1. Epub 2018 Sep 6.

Department of Pediatric Surgery, Royal Hospital for Children, Glasgow, United Kingdom.

Objective: To assess patterns of postnatal ventricular function and their relationship to prenatal and postnatal markers of disease severity in infants with congenital diaphragmatic hernia (CDH).

Study Design: In this observational case-control study of cardiac function in infants with CDH in the first 5 days of life, systolic and diastolic function in the right ventricle (RV) and left ventricle (LV) were assessed using speckle tracking echocardiography-derived global strain and tissue Doppler imaging. Correlation between cardiac function and prenatal observed:expected total fetal lung volume (TFLV), oxygenation index (OI), duration of intubation, and hospital length of stay were assessed. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.07.062DOI Listing
December 2018
5 Reads

Gastric volvulus through Morgagni hernia and intestinal diverticulosis in an adult patient: a case report.

BMC Surg 2018 08 29;18(1):67. Epub 2018 Aug 29.

Department of General Surgery, Dow University of Health Sciences, Civil Hospital Karachi, Karachi, Pakistan.

Background: Morgagni's hernia (MH) is a rare type of congenital diaphragmatic hernia with limited available literature. Late presentations are infrequent and the ones complicated due to gastric volvulus are even rarer. Another uncommon association of MH is with small bowel diverticulosis. Read More

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http://dx.doi.org/10.1186/s12893-018-0399-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116383PMC
August 2018
8 Reads

Morgagni Hernia Causing Incarcerated Bowel and Contributing to Cardiac Arrest.

Curr Probl Diagn Radiol 2018 Jul 31. Epub 2018 Jul 31.

Department of Radiology, Allegheny Health Network, Pittsburgh, PA.

A Morgagni hernia is a congenital diaphragmatic hernia (CDH)-incomplete formation of the diaphragm. Though congenital diaphragmatic hernias (CDHs) are a common class of birth defect, the majority are diagnosed either prenatally or shortly after birth since these patients can present with cardiopulmonary failure due to pulmonary hypoplasia or pulmonary hypertension. However, the Morgagni type of CDH predisposes it to go undetected well into adulthood. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.07.001DOI Listing
July 2018
7 Reads

Clinical cardiac assessment in newborns with prenatally diagnosed intrathoracic masses.

Ital J Pediatr 2018 Aug 22;44(1):98. Epub 2018 Aug 22.

Neonatal Intensive Care Unit, AOUP "P. Giaccone", Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro", University of Palermo, Via Alfonso Giordano n. 3, 90127, Palermo, Italy.

Background: Congenital space-occupying thoracic malformations and diaphragmatic hernia have in common pulmonary hypoplasia. Our study aims to assess cardiac involvement during post-natal adaptation.

Methods: A retrospective study was carried out on newborns with prenatally diagnosed intrathoracic mass. Read More

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http://dx.doi.org/10.1186/s13052-018-0543-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106891PMC
August 2018
17 Reads

Bochdalek hernia.

Authors:
Xiaofeng Hu Bin Liu

Lancet 2018 07 5;392(10141):60. Epub 2018 Jul 5.

Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

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http://dx.doi.org/10.1016/S0140-6736(18)31377-1DOI Listing
July 2018
4 Reads

Strangulated Morgagni hernia in an adult: Synchronous prolapse of the liver and transverse colon.

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):376-378

Department of Surgery, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo-Korea.

Morgagni hernia (MH) is a very rare congenital defect found in the anterior aspect of the diaphragm between the costal and sternal portions of the muscle. The most common defect is congenital diaphragmatic hernia, 90% of which are Bochdalek type. MHs account for approximately 3% of all diaphragmatic hernias. Read More

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http://dx.doi.org/10.5505/tjtes.2017.99045DOI Listing
July 2018
4 Reads
0.380 Impact Factor

Isolated impact of liver herniation on outcome in fetuses with congenital diaphragmatic hernia - A matched-pair analysis based on fetal MRI relative lung volume.

Eur J Radiol 2018 Aug 25;105:148-152. Epub 2018 May 25.

Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

Purpose: To evaluate liver-herniation as individual parameter on outcome in children with congenital diaphragmatic hernia.

Materials And Methods: In a retrospective matched-pair analysis based on observed to expected fetal lung volume (o/e FLV), birth weight, gestational age at time-point of examination, status of tracheal occlusion therapy and side of the defect the individual impact of liver-herniation on survival, need for extracorporeal membrane oxygenation (ECMO) therapy and chronic lung disease (CLD) was investigated. In total 61 pairs (122 patients) were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183019
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http://dx.doi.org/10.1016/j.ejrad.2018.05.024DOI Listing
August 2018
13 Reads

Extracorporeal membrane oxygenation support in a newborn with lower urinary tract obstruction and pulmonary hypoplasia: a case report.

J Med Case Rep 2018 Jul 17;12(1):210. Epub 2018 Jul 17.

Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Adenauerallee 119, 53113, Bonn, Germany.

Background: Survival of neonates with intrauterine renal insufficiency and oligo- or anhydramnios correlates with the severity of secondary pulmonary hypoplasia. Early prenatal diagnosis together with repetitive amnioinfusions and modern intensive care treatment have improved the prognosis of these neonates. Extracorporeal membrane oxygenation is an established treatment option, mainly applied to neonates with pulmonary hypoplasia caused by congenital diaphragmatic hernia. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1749-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048767PMC
July 2018
9 Reads

Preoperative sonographic evaluation of the defect size and the diaphragm rim in congenital diaphragmatic hernia - preliminary experience.

Pediatr Radiol 2018 10 5;48(11):1550-1555. Epub 2018 Jul 5.

Department of Radiology, Nagano Children's Hospital, Nagano, Japan.

Background: Sonographic assessment before congenital diaphragmatic hernia repair has rarely been studied.

Objective: To evaluate the accuracy of preoperative ultrasound in measuring the defect size and in anticipating the presence of a rim and thereby to determine ultrasound's usefulness in informing the surgical approach for definitive repair of congenital diaphragmatic hernia.

Materials And Methods: We performed a retrospective review of the medical records of seven children with left congenital diaphragmatic hernia who had undergone ultrasound and definitive repair between 2014 and 2017 at our institution. Read More

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http://dx.doi.org/10.1007/s00247-018-4184-yDOI Listing
October 2018
3 Reads

Morgagni's Hernia: Analysis of 21 Patients with Our Clinical Experience in Diagnosis and Treatment.

Indian J Surg 2018 Jun 6;80(3):239-244. Epub 2017 Jan 6.

4Thoracic Surgery Clinic, Istanbul Training and Research Hospital, Istanbul, Turkey.

A Morgagni's hernia is a congenital defect found in the anterior aspect of the diaphragm between the costal and the sternal portions of this muscle. This defect is also referred to as the space of Larrey. It has been reported that 70% of patients with Morgagni's hernia are female, 90% of the hernias are right-sided, and 92% of the hernias have hernia sacs. Read More

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http://dx.doi.org/10.1007/s12262-016-1580-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014954PMC
June 2018
14 Reads

Congenital diaphragmatic hernia has a better prognosis when associated with a hernia sac.

Prenat Diagn 2018 08 11;38(9):638-644. Epub 2018 Jul 11.

Reference Center for Rare Disease: Congenital Diaphragmatic Hernia, Clamart, France.

Objective: To evaluate neonatal mortality and morbidity up to 6 months in neonates with congenital diaphragmatic hernia (CDH) with or without a hernia sac.

Methods: Seventy-two cases of isolated CDH were included in a retrospective single-center study between January 2010 and December 2016. Hernia sac was defined at the time of surgery or at postmortem examination if the neonate died before surgery. Read More

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http://dx.doi.org/10.1002/pd.5326DOI Listing
August 2018
4 Reads

The Possibility of Postmortem Magnetic Resonance Imaging for the Diagnostics of Lung Hypoplasia.

Bull Exp Biol Med 2018 Jun 20;165(2):288-291. Epub 2018 Jun 20.

V. I. Kulakov National Medical Research Centre of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

We explored the possibility of using postmortem MRI for the diagnostics of lung hypoplasia associated with innate diaphragmatic hernia in neonates. The main experimental group consisted of 17 newborns with innate diaphragmatic hernia including 10 non-operated newborns and 7 newborns died after surgery for innate diaphragmatic hernia. It was demonstrated that postmortem MRI allows objective quantitative assessment of the absolute and relative dimensions of the lungs in the thoracic cavity and thereby reveals their hypoplasia, which contributes to the determination of tanatogenesis. Read More

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http://dx.doi.org/10.1007/s10517-018-4150-6DOI Listing
June 2018
7 Reads

Proposal for standardized prenatal ultrasound assessment of the fetus with congenital diaphragmatic hernia by the European reference network on rare inherited and congenital anomalies (ERNICA).

Prenat Diagn 2018 08 23;38(9):629-637. Epub 2018 Jul 23.

Clinical Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

Congenital diaphragmatic hernia is a rare disease associated with high mortality and morbidity. Antenatal ultrasound screening identifies more than 70% of cases, providing the opportunity for in utero referral to a tertiary care center for expert assessment and perinatal management. Additional genetic and morphologic assessment may be used to rule out associated anomalies. Read More

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http://dx.doi.org/10.1002/pd.5297DOI Listing
August 2018
15 Reads

An Unexpected Adverse Event during Colonoscopy Screening: Bochdalek Hernia.

Korean J Gastroenterol 2018 05;71(5):290-293

Medical Institute, Daegu, Korea.

Bochdalek hernia (BH) is defined as herniated abdominal contents appearing throughout the posterolateral segment of the diaphragm. It is usually observed during the prenatal or newborn period. Here, we report a case of an adult patient with herniated omentum and colon due to BH that was discovered during a colonoscopy. Read More

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http://dx.doi.org/10.4166/kjg.2018.71.5.290DOI Listing
May 2018
38 Reads

Prenatal intervention for the management of congenital diaphragmatic hernia.

Pediatr Surg Int 2018 Jun 30;34(6):579-587. Epub 2018 Apr 30.

Texas Children's Fetal Center, Baylor College of Medicine, 6701 Fannin St, Suite 1210, Houston, TX, 77030, USA.

Congenital diaphragmatic hernia (CDH) is the result of incomplete formation of the diaphragm that occurs during embryogenesis. The defect in the diaphragm permits the herniation of abdominal organs into the thoracic cavity contributing to the impairment of normal growth and development of the fetal lung. In addition to the hypoplastic lung, anomalies of the pulmonary arterioles worsen the pulmonary hypertension that can have detrimental effects in severe cases. Read More

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http://dx.doi.org/10.1007/s00383-018-4270-0DOI Listing
June 2018
5 Reads

Improving outcome in congenital diaphragmatic hernia - experience of a tertiary center without ECMO.

J Neonatal Perinatal Med 2018 ;11(1):37-43

Pediatric Intensive Care Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, EPE, Portugal.

Background: Congenital diaphragmatic hernia (CDH) has a high mortality rate, representing a therapeutic challenge. Prenatal diagnosis (PND) is essential in defining optimal perinatal strategy, particularly delivery planning. Hospital Pediátrico de Coimbra is the referral centre for all neonatal surgery, particularly CDH, for the central region of Portugal. Read More

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http://dx.doi.org/10.3233/NPM-181710DOI Listing
October 2018
3 Reads

Follow-up of fetuses with congenital diaphragmatic hernia: The quantitative lung index.

Eur J Obstet Gynecol Reprod Biol 2018 Jun 26;225:22-25. Epub 2018 Mar 26.

Maternal-fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Objective: To assess the longitudinal behavior of Quantitative Lung Index (QLI) for the follow-up of fetuses with congenital diaphragmatic hernia.

Study Design: Retrospective study of fetuses with isolated left congenital diaphragmatic hernia. The fetuses were assessed by ultrasound at different gestational ages and QLI was retrospectively calculated by means of previous lung-to-head ratio measurements. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.03.036DOI Listing
June 2018
2 Reads

3D Virtual Broncoscopy before FETO Procedure in a Fetus with Severe, Isolated Left Congenital Diaphragmatic Hernia.

Fetal Pediatr Pathol 2018 Apr 2;37(2):134-139. Epub 2018 Apr 2.

f Clínica de Diagnóstico por Imagem (CDPI), Radiology , Rio de Janeiro , Brazil.

Introduction: Congenital diaphragmatic hernia (CDH) is a life-threatening event in severe forms and fetuses affected may benefit from in utero treatment by fetoscopic endotracheal occlusion (FETO).

Materials And Methods: Application of 3D virtual bronchoscopy in a case of severe, isolated, left CDH before performing FETO procedure at 27 week's gestation is reported.

Results: The 3D virtual imaging of the fetal trachea was technically useful in planning the real FETO procedure. Read More

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http://dx.doi.org/10.1080/15513815.2018.1445148DOI Listing
April 2018
7 Reads

Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia.

Prenat Diagn 2018 05 15;38(6):422-427. Epub 2018 Apr 15.

Fetal Medicine Mexico, Fetal Surgery Research Unit, Children and Women's Specialty Hospital; Unidad de Investigación en Neurodesarrollo, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Campus Juriquilla, Juriquilla, Queretaro, Mexico.

Objective: To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).

Methods: Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E' and E'/A' ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left-sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.

Results: In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35 ms vs 28 ms, P < . Read More

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http://dx.doi.org/10.1002/pd.5253DOI Listing
May 2018
10 Reads

A rare case report of Morgagni Hernia with Organo-Axial Gastric Volvulus and concomitant Para-esophageal hernia, repaired laparoscopically in a Septuagenarian.

Int J Surg Case Rep 2018 16;45:45-50. Epub 2018 Mar 16.

Department of General Surgery, B.J. Medical College & Sassoon General Hospital, Near Pune Railway Station, Pune, Maharashtra, 411001, India. Electronic address:

Introduction: Simultaneous occurrence of Morgagni and the Para-esophageal hernia is a rare clinical condition with eight case reports in the English-language literature and only four managed laparoscopically. We describe a case of a Septuagenarian patient with Morgagni and concomitant Para-esophageal hernia treated laparoscopically.

Presentation Of A Case: A 71-year-old male patient, presented with a one-month history of regurgitation of acid, retrosternal burning and vomiting after eating. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000763PMC
March 2018
8 Reads

Anatomical associations and radiological characteristics of Scimitar syndrome on CT and MR.

J Cardiovasc Comput Tomogr 2018 Jul - Aug;12(4):286-289. Epub 2018 Feb 3.

Mallinckrodt Institute of Radiology at Washington University, St Louis, MO, USA.

Purpose: To report the anatomical associations and radiological characteristics of Scimitar syndrome on CT and MR.

Materials And Methods: Retrospective review of the medical records between February 2001 and February 2016 was performed. To identify patients, radiological reports were queried for "Scimitar" or "partial anomalous pulmonary venous return. Read More

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http://dx.doi.org/10.1016/j.jcct.2018.02.001DOI Listing
November 2018
7 Reads

Multiple midline defects identified in a litter of golden retrievers following gestational administration of prednisone and doxycycline: a case series.

BMC Vet Res 2018 Mar 12;14(1):86. Epub 2018 Mar 12.

Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA, 95616, USA.

Background: The teratogenic effects of immunomodulatory and certain antimicrobial therapies are described in small rodents and humans. While the described teratogenic effects in small rodents have been extrapolated to make conclusions about its use in the pregnant dam, teratogenic effects of prednisone and doxycycline have not yet been reported in the dog. Here we report and describe midline defects observed in a litter of golden retriever puppies exposed to mid-gestational immunosuppressive and antimicrobial therapy. Read More

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http://dx.doi.org/10.1186/s12917-018-1419-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848590PMC
March 2018
18 Reads

Diminished Cardiac Performance and Left Ventricular Dimensions in Neonates with Congenital Diaphragmatic Hernia.

Pediatr Cardiol 2018 Jun 9;39(5):993-1000. Epub 2018 Mar 9.

Division of Cardiology, Echocardiography Laboratory, Department of Pediatrics, Stanford University - Lucile Packard Children's Hospital, Stanford, CA, USA.

Introduction: Newborns with congenital diaphragmatic hernia (CDH) have varying degrees of pulmonary hypoplasia and pulmonary hypertension (PH), and there is limited evidence that cardiac dysfunction is present. We sought to study early neonatal biventricular function and performance in these patients by reviewing early post-natal echocardiography (ECHO) measurements and comparing them to normal term newborns.

Methods: Retrospective case-control study reviewing clinical and ECHO data on term newborns with CDH and normal controls born between 2009 and 2016. Read More

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http://dx.doi.org/10.1007/s00246-018-1850-7DOI Listing
June 2018
4 Reads

Laparoscopic Treatment of Morgagni Hernia: Report of Three Cases.

Acta Clin Croat 2017 Jun;56(2):318-322

Department of Hepatobiliary Surgery, Sveti Duh University Hospital, Zagreb, Croatia.

We report on three cases of diaphragmatic (Morgagni) hernia with different clinical presentation. It is important to consider the possibility of this rare but potentially very dangerous condition in patients with respiratory problems and pain in the upper abdomen. Before laparoscopy, two different approaches were used in diaphragmatic hernia operations (abdominal and thoracic approach). Read More

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http://dx.doi.org/10.20471/acc.2017.56.02.16DOI Listing
June 2017
7 Reads

Abrogation of TGF-beta signalling in TAGLN expressing cells recapitulates Pentalogy of Cantrell in the mouse.

Sci Rep 2018 Feb 26;8(1):3658. Epub 2018 Feb 26.

Manchester Academic Health Science Centre, Division of cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Pentalogy of Cantrell (PC) is a rare multi-organ congenital anomaly that impedes ventral body wall closure and results in diaphragmatic hernia, intra- and pericardial defects. The underlying cellular and molecular changes that lead to these severe developmental defects have remained unknown largely due to the lack of representative animal models. Here we provide in depth characterization of a mouse model with conditional ablation of TGFβRII in Transgelin (Tagln) expressing cells. Read More

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http://dx.doi.org/10.1038/s41598-018-21948-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826924PMC
February 2018
2 Reads

Antenatal management of congenital diaphragmatic hernia today and tomorrow.

Minerva Pediatr 2018 Jun 23;70(3):270-280. Epub 2018 Feb 23.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Leuven, Belgium -

Congenital diaphragmatic hernia is rare birth defect, which can be easily corrected after birth. The main problem is that herniation of viscera during fetal life impairs lung development, leading to a 30% mortality and significant morbidity. In isolated cases the outcome can be accurately predicted prenatally by medical imaging. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05186-1DOI Listing
June 2018
17 Reads

Cardiac Function Assessments in Left Bochdalek's Hernia: Clinical Relevance.

Pediatr Cardiol 2018 Apr 23;39(4):829-836. Epub 2018 Feb 23.

Pediatric Surgery, Monash Health, Melbourne, Australia.

The objectives of this study were to characterize peri-operative echocardiographic (ECHO) assessments of right ventricular (RV) function and pulmonary hypertension (PH) and ascertain correlation with clinical outcomes in infants with left Bochdalek's hernia (LBH). This retrospective study in a quaternary neonatal intensive care unit involved electronic database search for infants with LBH during January 2009 to July 2017. Demographics, outcomes, and ECHO parameters were accessed from archived databases. Read More

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http://dx.doi.org/10.1007/s00246-018-1834-7DOI Listing
April 2018
3 Reads

Improved Outcomes in Management of Hypoplastic Left Heart Syndrome Associated With Congenital Diaphragmatic Hernia: an Algorithmic Approach.

Semin Thorac Cardiovasc Surg 2018 12;30(2):191-196. Epub 2018 Feb 12.

Department of Pediatric Cardiothoracic Surgery, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:

Hypoplastic left heart syndrome (HLHS) is the second most common congenital heart disease associated with congenital diaphragmatic hernia (CDH). The reported survival rate of neonates with CDH and HLHS is only 1%-5%. We review our experience with CDH and HLHS and compare our outcomes with published literature. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2018.02.010DOI Listing
November 2018
5 Reads

Acute pancreatitis due to a Bochdalek hernia in an adult patient.

BMJ Case Rep 2018 Feb 2;2018. Epub 2018 Feb 2.

Emergency Surgery Unit, St Orsola Hospital, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1136/bcr-2017-223852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812407PMC
February 2018
4 Reads