1,796 results match your criteria Congenital Diaphragmatic Hernia Imaging


Prenatal sonography of extracorporeal ductus venosus in association with large fetal gastroschisis.

J Clin Ultrasound 2020 Jun 29. Epub 2020 Jun 29.

The Division of Maternal Fetal Medicine, The Department of Obstetrics and Gynecology, State University of New York (SUNY), Downstate Heath Sciences University, Brooklyn, New York, USA.

Liver herniation commonly associated with omphalocele occurs in only approximately 2.3% to 16% of fetuses with gastroschisis. Liver herniation in such cases is associated with considerably decreased survival rates (43% vs 97% with or without liver herniation, respectively). Read More

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http://dx.doi.org/10.1002/jcu.22881DOI Listing

Laparoscopic repair of Morgagni's hernia in an elderly female patient.

J Surg Case Rep 2020 Jun 15;2020(6):rjaa182. Epub 2020 Jun 15.

General Surgery, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

Morgagni's hernia is a very uncommon congenital diaphragmatic hernia. A few patients may remain asymptomatic until adulthood. Clinical presentation may include bowel obstruction, chest pain or dyspnoea. Read More

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http://dx.doi.org/10.1093/jscr/rjaa182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295565PMC

The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain.

J Neuroimaging 2020 Jul 17;30(4):477-485. Epub 2020 Jun 17.

Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Bern, Switzerland.

Background And Purpose: The changing MRI signal accompanying brain maturation in fetal brains can be quantified on apparent diffusion coefficient (ADC) maps. Deviations from the natural course of ADC values may reflect structural pathology. The purpose of this study was to determine the influence of fetal pathologies on the ADC values in different regions of the fetal brain and their evolution with increasing gestational age. Read More

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http://dx.doi.org/10.1111/jon.12727DOI Listing

Acute intrathoracic gastric volvulus: A rare delayed presentation of congenital diaphragmatic hernia: A case report.

Int J Surg Case Rep 2020 11;70:123-125. Epub 2020 May 11.

Department of Pediatric Surgery, Faculty of Medicine, University of Alexandria, Egypt. Electronic address:

Introduction: Acute intrathoracic gastric volvulus occurs when the stomach undergoes organoaxial rotation in the chest due presence of a diaphragmatic defect. Gastric volvulus associated with congenital diaphragmatic hernia is extremely rare and can be explained as 2 of the 4 ligaments supporting the stomach (gastrophrenic and gastrosplenic) which are connected to the left diaphragm may become elongated or absent. According to the current literature, only 27 pediatric cases have been reported so far. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229233PMC

Prenatal prediction of postnatal survival in fetuses with congenital diaphragmatic hernia using MRI: lung volume measurement, signal intensity ratio, and effect of experience.

J Matern Fetal Neonatal Med 2020 Mar 25:1-9. Epub 2020 Mar 25.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Vrije Universiteit Brussel, Brussels, Belgium.

To evaluate various signal intensity ratios in isolated congenital diaphragmatic hernia (CDH) and to compare their potential in predicting survival with that of the observed-to-expected (O/E) ratio of total fetal lung volume (TFLV) using magnetic resonance imaging (MRI) measurements. Our second objective was to evaluate the impact of operator's experience in comparing the prediction of postnatal survival by O/E-TFLV. In 75 conservatively managed CDH fetuses and in 50 who underwent fetoscopic endoluminal tracheal occlusion (FETO), the fetal lung-to-amniotic fluid, lung-to-liver, lung-to-muscle, lung-to-spinal fluid signal intensity ratios, respectively LAFSIR, LLSIR, LMSIR, and LSFSIR, were measured, as was O/E-TFLV. Read More

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http://dx.doi.org/10.1080/14767058.2020.1740982DOI Listing

Congenital hypothyroidism, cardiac defects, and pancreatic agenesis in an infant with GATA6 mutation.

Am J Med Genet A 2020 06 24;182(6):1496-1499. Epub 2020 Mar 24.

Division of Clinical and Metabolic Genetics, The Hospital for Sickkids, University of Toronto, Toronto, Ontario, Canada.

GATA6 pathogenic variants primarily manifest a phenotype with pancreatic agenesis and cardiac malformations. However, additional congenital malformations affecting the biliary system, congenital diaphragmatic hernia and developmental delay have been reported. We report a newborn, prenatally diagnosed with truncus arteriosus and intrauterine growth restriction, who was postnatally found to have pancreatic agenesis associated with neonatal diabetes and hepatobiliary abnormalities. Read More

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http://dx.doi.org/10.1002/ajmg.a.61569DOI Listing

Fetal therapies as standard prenatal care in Japan.

Obstet Gynecol Sci 2020 Mar 18;63(2):108-116. Epub 2020 Feb 18.

Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

With recent advances in fetal medicine, various attempts have been made to save fetuses facing perinatal death or devastating consequences despite optimal management after birth. The concept of the fetus as a patient has been established through the application of treatments. This paper reviews fetal therapies in order to highlight the role of perinatal medicine as standard prenatal care. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.2.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073354PMC

Morgagni-Larrey Hernia: A Possible Cause of Recurrent Lower Respiratory Tract Infections.

Cureus 2019 Feb 7;11(2):e4035. Epub 2019 Feb 7.

Thoracic Surgery, Nishtar Medical University Hospital, Multan, PAK.

Morgagni-Larrey hernia is an exceedingly rare presentation of congenital diaphragmatic hernia. Despite its rarity, it is associated with significant risk of morbidity and mortality. Herein, we describe a unique case report of an elderly woman who presented with left-sided chest pain, dyspnea, and chronic history of recurrent respiratory tract infections. Read More

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http://dx.doi.org/10.7759/cureus.4035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053801PMC
February 2019

Morgagni-Larrey diaphragmatic hernia repair in adult patients: a retrospective single-center experience.

Hernia 2020 Feb 29. Epub 2020 Feb 29.

Department of General, Visceral, Thoracic, Transplant and Pediatric Surgery, University Hospital of Giessen, Giessen, Germany.

Purpose: Morgagni-Larrey congenital diaphragmatic hernia (MLH) is rare in adult patients and surgery is performed infrequently. The evidence regarding the most beneficial treatment modality is low. Nevertheless, with increasing experience in minimally-invasive surgery, the literature proves the laparoscopic approach as being safely feasible. Read More

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http://dx.doi.org/10.1007/s10029-020-02147-0DOI Listing
February 2020

Fetal cerebral vascular impedance is abnormal in left congenital diaphragmatic hernia.

Ultrasound Obstet Gynecol 2020 Feb 18. Epub 2020 Feb 18.

San Francisco Department of Pediatrics, The University of California.

Objectives: Congenital diaphragmatic hernia (CDH) can cause significant mass effect in the fetal thorax displacing the heart into the opposite hemithorax. In left CDH (L-CDH), this is associated with smaller left-sided cardiac structures and lower left ventricular cardiac output (LVCO). The effect of these physiologic changes on cerebral blood flow is not well understood. Read More

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http://dx.doi.org/10.1002/uog.21992DOI Listing
February 2020

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion.

J Surg Res 2020 Jun 31;250:23-38. Epub 2020 Jan 31.

Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Background: Fetal tracheal occlusion (TO) is an experimental therapeutic approach to stimulate lung growth in the most severe congenital diaphragmatic hernia (CDH) cases. We have previously demonstrated a heterogeneous response of normal fetal rabbit lungs after TO with the appearance of at least two distinct zones. The aim of this study was to examine the fetal lung response after TO in a left CDH fetal rabbit model. Read More

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http://dx.doi.org/10.1016/j.jss.2019.12.025DOI Listing

Comparison of mediastinal shift angles obtained with ultrasound and magnetic resonance imaging in fetuses with isolated left sided congenital diaphragmatic hernia.

J Matern Fetal Neonatal Med 2020 Jan 23:1-6. Epub 2020 Jan 23.

Department of Medical and Surgical Neonatology, Fetal Medicine and Surgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

To compare ultrasound (US) and magnetic resonance imaging (MRI) in the assessment of mediastinal shift angles (MSAs) in fetuses affected by isolated left congenital diaphragmatic hernia (CDH). The use of MRI-MSA and US-MSA as prognostic factor for postnatal survival in fetal left CDH was also explored. This was an observational study of 29 fetuses with prenatally diagnosed isolated left CDH, assessed with both US and MRI examinations between January 2015 and December 2018. Read More

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http://dx.doi.org/10.1080/14767058.2020.1716714DOI Listing
January 2020

Fetal MRI assessment of mediastinal shift angle in isolated left congenital diaphragmatic hernia: A new postnatal survival predictive tool?

Prenat Diagn 2020 01 27;40(1):136-141. Epub 2019 Dec 27.

Department of Imaging, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy.

Objective: To quantify the mediastinal shift angle (MSA) in fetuses with isolated left congenital diaphragmatic hernia (CDH) by magnetic resonance imaging and evaluate survival.

Method: Fetuses from singleton pregnancies with isolated left CDH were matched for gestational age with controls without thoracic malformations. For all fetuses the MSA was determined by two operators and inter-operator variability and differences between cases and controls were investigated. Read More

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http://dx.doi.org/10.1002/pd.5619DOI Listing
January 2020

Herniation of the Right Renal Pelvis through a Posterolateral Diaphragmatic Defect (Bochdalek Hernia).

Urology 2020 Mar 20;137:e10-e11. Epub 2019 Dec 20.

Department of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, Puttaparthi, Andhra Pradesh, India.

Diaphragmatic herniations are the rarest form of ureteral herniations with only around 9 cases reported since 1958. Though uncommon, it should be considered in the differential diagnosis of a posterior diaphragmatic or paraspinal opacity with associated hydronephrosis. Correct diagnosis is of paramount importance and can be easily established by noninvasive imaging technique. Read More

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http://dx.doi.org/10.1016/j.urology.2019.12.009DOI Listing

Calculating Observed-to-Expected Total Fetal Lung Volume in CDH Fetuses in Twin Gestation: Is There a Better Way?

Fetal Diagn Ther 2020 20;47(7):545-553. Epub 2019 Dec 20.

Department of Surgery, Section of Pediatric Surgery, University of Michigan, Michigan Medicine, Ann Arbor, Michigan, USA,

Background: Congenital diaphragmatic hernia (CDH) is a potentially lethal birth defect, and identifying prenatal predictors of outcome is important. Observed-to-expected total fetal lung volume (o/e TFLV) has been shown to be a predictor of severity and useful in risk stratification but is variable due to different TFLV formulas.

Objectives: To calculate o/e TFLV for CDH patients part of a twin gestation using the unaffected sibling as an internal control and comparing these values to those calculated using published formulas for TFLV. Read More

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http://dx.doi.org/10.1159/000504510DOI Listing
December 2019

Isolated Thoracoschisis with Rib Agenesis and Liver Herniation: A Case Report.

Am J Case Rep 2019 Dec 21;20:1915-1919. Epub 2019 Dec 21.

Division of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USA.

BACKGROUND Thoracoschisis is a very rare congenital birth defect defined by the herniation of intra-abdominal organs through a defect in the thoracic wall. Though often associated with other birth defects as a part of the "limb-body wall complex" deformities, thoracoschisis has very rarely been reported as an isolated finding. CASE REPORT Here we present the case of a 30-day-old term male infant with an isolated left thoracoschisis managed successfully by primary closure. Read More

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http://dx.doi.org/10.12659/AJCR.919125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938396PMC
December 2019

Discordant prenatal ultrasound and fetal MRI in CDH: wherein lies the truth?

J Pediatr Surg 2019 Nov 26. Epub 2019 Nov 26.

Department of Surgery, Section of Pediatric Surgery, University of Michigan, Michigan Medicine; Fetal Diagnosis and Treatment Center, University of Michigan, Michigan Medicine. Electronic address:

Purpose: Prenatal risk assessment of congenital diaphragmatic hernia (CDH) relies on prenatal ultrasound (U/S) and fetal magnetic resonance imaging (MRI). When the modalities differ in prognosis, it is unclear which is more reliable.

Methods: Retrospective chart review identified cases of prenatally diagnosed CDH from 4/2010-6/2018 meeting inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.11.007DOI Listing
November 2019

Non-operative management of extralobar pulmonary sequestration: a safe alternative to resection?

Pediatr Surg Int 2020 Mar 9;36(3):325-331. Epub 2019 Nov 9.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Fegan 3rd Floor, Boston, MA, 02115, USA.

Purpose: This retrospective cohort study compares the natural history of patients with extralobar sequestrations (ELS) who do not undergo intervention with those who undergo resection to assess the safety of non-operative management.

Methods: 126 patients with pulmonary sequestrations or congenital pulmonary airway malformations born between 1999 and 2016 were identified. 49 patients had ELS on postnatal imaging, but two were excluded for associated congenital diaphragmatic hernia. Read More

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http://dx.doi.org/10.1007/s00383-019-04590-2DOI Listing

An Elderly Woman with Exertional Dyspnoea and T-Wave Inversions on Electrocardiography.

Can J Cardiol 2019 Nov 22;35(11):1605.e1-1605.e3. Epub 2019 Aug 22.

Department of Cardiology, National University Heart Centre, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

We present a case of a 75-year-old woman with cardiac dextroposition who presented for preoperative cardiac evaluation because of exertional dyspnoea. On examination, heart sounds were best appreciated on the right, and bowel sounds were heard over the left hemithorax. Electrocardiography showed widespread T-wave inversions. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.08.019DOI Listing
November 2019

Variability in antenatal prognostication of fetal diaphragmatic hernia across the North American Fetal Therapy Network (NAFTNet).

Prenat Diagn 2020 02 8;40(3):342-350. Epub 2019 Dec 8.

Fetal Medicine Unit, Ontario Fetal Centre, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluate variability in antenatal sonographic prognostication of congenital diaphragmatic hernia (CDH) within the North American Fetal Therapy Network (NAFTNet).

Methods: NAFTNet centre were invited to complete a questionnaire and participate in videoconference calls, during which participants were observed while measuring lung area by ultrasound using the anteroposterior (AP) method, longest method, and trace method. Each center identified 1-2 experienced fetal medicine specialist(s) or medical imaging specialists locally to participate in the study. Read More

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http://dx.doi.org/10.1002/pd.5560DOI Listing
February 2020
1 Read

Congenital Eventration of Diaphragm Presenting As Diaphragmatic Hernia: A Case Report.

Mymensingh Med J 2019 Oct;28(4):952-956

Professor Jagadish C Das, Professor, Department of Neonatology, Chattogram Medical College, Chattogram, Bangladesh; E-mail: jagadishcdas@ yahoo.com.

Eventration of diaphragm is an abnormal elevation of diaphragmatic musculature while retaining normal attachments to the sternum, ribs and dorsolumber spine. It is a rare anomaly where the continuity of diaphragm remains intact. Pathological process can affect either all or only a portion of hemidiaphragm. Read More

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October 2019
4 Reads

The assessment of cardiac function with tissue Doppler imaging in fetuses with congenital diaphragmatic hernia.

J Matern Fetal Neonatal Med 2020 Apr 6;33(7):1233-1238. Epub 2019 Oct 6.

Department of Maternal Fetal Medicine, Akdeniz University, Antalya, Turkey.

This study aimed to evaluate the cardiac function of fetuses with congenital diaphragmatic hernia by conventional echocardiography and spectral tissue Doppler imaging (s-TDI) and to evaluate the relationship between cardiac function and the severity of pulmonary hypoplasia. We also aimed to investigate the effect of diaphragmatic hernia side on fetal cardiac function. Fetal cardiac function were evaluated in 28 fetuses (20 with left-sided and 8 with right-sided) complicated with isolated congenital diaphragmatic hernia (CDH) and 56 gestational age matched control in this single center prospective study. Read More

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http://dx.doi.org/10.1080/14767058.2019.1674806DOI Listing
April 2020
1 Read

Surgical repair of bilateral congenital diaphragmatic hernia associated with hepatopulmonary fusion.

Authors:
Osama A Bawazir

Saudi Med J 2019 Sep;40(9):949-953

Department of Surgery, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Bilateral congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with high neonatal mortality. The condition is rarely associated with hepatopulmonary fusion (HPF). We reported the surgical repair of bilateral CDH in a male infant aged 6 weeks. Read More

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http://dx.doi.org/10.15537/smj.2019.9.24378DOI Listing
September 2019
2 Reads

Jarcho-Levin Syndrome and Concomitant Carotid Glomus Tumor: First Reported Case.

World Neurosurg 2019 Dec 31;132:236-238. Epub 2019 Aug 31.

Department of Radiology, Harran University, Faculty of Medicine, Sanliurfa, Turkey.

Background: Jarcho-Levin syndrome (JLS) is a rare congenital disorder characterized by different clinical and radiologic findings. The disease was first reported by Jarcho and Levin in 1938, and it was described as the presence of various malformations or abnormal fusion in the thoracic vertebrae and ribs, short trunk, and respiratory distress.

Case Description: In our case, fusion at the thoracic and cervical vertebrae, butterfly vertebrae, and a crablike-shaped thorax was present. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.179DOI Listing
December 2019
4 Reads

The role of ECMO in the management of congenital diaphragmatic hernia.

Semin Perinatol 2020 02 30;44(1):151166. Epub 2019 Jul 30.

Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA, United States; Department of Surgery, University of California Irvine Medical Center, 505 S. Main St, #225, Orange, CA 92868, United States. Electronic address:

Congenital diaphragmatic hernia (CDH) is the most common indication for extra-corporeal membrane oxygenation (ECMO) for neonatal respiratory failure. CDH management is evolving with advanced prenatal diagnostic imaging modalities. The risk profiles of infants receiving ECMO for CDH are shifting towards higher risk. Read More

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http://dx.doi.org/10.1053/j.semperi.2019.07.005DOI Listing
February 2020
5 Reads

Avoiding misdiagnosis in postnatal presentation of congenital diaphragmatic hernia: A report of two cases and review of radiologic features.

Radiol Case Rep 2019 Oct 16;14(10):1288-1292. Epub 2019 Aug 16.

Department of Pediatric Radiology, Children's Hospital of Wisconsin, 9000 W. Wisconsin Ave., MS-721 Milwaukee, WI 53226 USA.

Diagnosis of a congenital diaphragmatic hernia after the first day of life can be challenging. The clinical symptoms are often nonspecific, and initial radiographic findings in these patients may mimic many other acute chest conditions, including pneumonia, pleural effusion, and pneumothorax. In turn, diagnostic uncertainty may expose the patient to unnecessary and even potentially harmful interventions such as thoracostomy tube placement. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706528PMC
October 2019
3 Reads

Fetal intervention for congenital diaphragmatic hernia.

Semin Pediatr Surg 2019 Aug 18;28(4):150818. Epub 2019 Jul 18.

Johns Hopkins Hospital, Division of General Pediatric Surgery, Baltimore, MD, United States. Electronic address:

Congenital diaphragmatic hernia (CDH) is a condition that results from incomplete diaphragm formation during embryogenesis. The diaphragmatic defect allows for herniation of abdominal viscera into the chest, and the resulting pulmonary hypoplasia and pulmonary hypertension can lead to cardiorespiratory failure in the neonatal period. There is a wide spectrum of disease severity in CDH, and while advances in neonatal care and the introduction of extracorporeal membrane oxygenation have improved outcomes in many cases, the most severe defects are still associated with high morbidity and mortality. Read More

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http://dx.doi.org/10.1053/j.sempedsurg.2019.07.001DOI Listing
August 2019
3 Reads

Herniated Liver Mimicking Right Atrial Mass.

Pediatr Cardiol 2019 Dec 22;40(8):1759-1760. Epub 2019 Aug 22.

Division of Pediatric Radiology, Department of Radiology, Medical University Graz, Graz, Austria.

In a newborn that underwent surgery due to omphalocele, postoperative echocardiography revealed an accidental finding of a right atrial (RA) mass. Echocardiography prior to surgery was inconspicuous. Applying color Doppler, a pulsatile flow exiting the mass could be depicted and a tubular structure lancing through the mass. Read More

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http://dx.doi.org/10.1007/s00246-019-02186-0DOI Listing
December 2019
2 Reads

Prenatal diagnosis, imaging, and prognosis in Congenital Diaphragmatic Hernia.

Semin Perinatol 2020 02 30;44(1):51163. Epub 2019 Jul 30.

Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, AP-HP, Université Paris Sud, 157 rue de la porte de Trivaux, 92140 CLAMART, APHP, Clamart, France; Centre Référence Maladie Rare, Hernie de Coupole Diaphragmatique, Clamart, France.

Antenatal ultrasound screening identifies more than 60% of Congenital Diaphragmatic Hernia (CDH) cases and provides the opportunity for in utero referral to a tertiary care center for expert assessment and perinatal management. Prenatal assessment of fetuses with CDH has tremendously improved over the past ten years. The outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1053/j.semperi.2019.07.002DOI Listing
February 2020
4 Reads

Prenatal Imaging Features and Postnatal Factors Associated with Gastrointestinal Morbidity in Congenital Diaphragmatic Hernia.

Fetal Diagn Ther 2020 21;47(4):252-260. Epub 2019 Aug 21.

Texas Children's Fetal Center, Texas Children's Hospital and the Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA,

Background: To perform a comprehensive assessment of postnatal gastrointestinal (GI) morbidity and determine the prenatal imaging features and postnatal factors associated with its development in patients with congenital diaphragmatic hernia (CDH).

Materials And Methods: A retrospective review was conducted of all infants evaluated for CDH at a quaternary fetal center from February 2004 to May 2017. Prenatal imaging features and postnatal variables were analyzed. Read More

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http://dx.doi.org/10.1159/000501555DOI Listing
August 2019
7 Reads
2.295 Impact Factor

Pränatale sonografische Diagnostik von Lungenfehlbildungen.

Authors:
Michael Bolz

Rofo 2019 Sep 20;191(S 02):S106-S109. Epub 2019 Aug 20.

Universitätsfrauenklinik und Poliklinik Rostock.

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http://dx.doi.org/10.1055/a-0943-1068DOI Listing
September 2019

Timing of Prenatal Magnetic Resonance Imaging in the Assessment of Congenital Diaphragmatic Hernia.

Fetal Diagn Ther 2020 15;47(3):205-213. Epub 2019 Aug 15.

Texas Children's Fetal Center and The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA,

Introduction: Fetal magnetic resonance imaging (MRI) has been used to stratify severity of congenital diaphragmatic hernia (CDH) after ultrasound diagnosis. The purpose of this study was to determine if timing of MRI influenced prediction of severity of outcome in CDH.

Methods: A single institution retrospective review of all CDH referred to our institution from February 2004 to May 2017 was performed. Read More

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http://dx.doi.org/10.1159/000501556DOI Listing
August 2019
4 Reads

A new approach using image analysis to assess pulmonary hypoplasia in the fetal lamb diaphragmatic hernia model.

Pediatr Surg Int 2019 Oct 14;35(10):1131-1136. Epub 2019 Aug 14.

Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 2168511, Japan.

Background: In congenital diaphragmatic hernia (CDH), there is pulmonary hypoplasia (PH) and also pulmonary vascular and bronchial abnormalities. Few studies have investigated bronchial maldevelopment in CDH. We evaluated bronchial area (BA) by bronchography in a fetal lamb DH model to develop a measure of PH. Read More

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http://dx.doi.org/10.1007/s00383-019-04543-9DOI Listing
October 2019
3 Reads

A multifactorial severity score for left congenital diaphragmatic hernia in a high-risk population using fetal magnetic resonance imaging.

Pediatr Radiol 2019 12 14;49(13):1718-1725. Epub 2019 Aug 14.

Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Adverse outcomes for infants born with left congenital diaphragmatic hernia (CDH) have been correlated with fetal imaging findings.

Objective: We sought to corroborate these correlations in a high-risk cohort and describe a predictive mortality algorithm combining multiple imaging biomarkers for use in prenatal counseling.

Materials And Methods: We reviewed fetal MRI examinations at our institution from 2004 to 2016 demonstrating left-side CDH. Read More

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http://dx.doi.org/10.1007/s00247-019-04478-2DOI Listing
December 2019
5 Reads

Integrating Fetal Therapy Procedures in an Established Labor and Delivery Service.

Authors:
Jennifer Kearney

AORN J 2019 08;110(2):155-161

Treating fetal disease in utero is a specialized aspect of obstetric medicine that continues to develop as new technology and better imaging techniques are introduced. Surgical interventions may improve outcomes in fetal diseases such as fetal anemia, spina bifida, and congenital diaphragmatic hernia; however, the addition of a dedicated fetal treatment center to an established busy labor and delivery unit requires facility resources and support. Fetal medicine and labor and delivery leaders can develop a successful fetal therapy service when they partner with fetal medicine specialists, obstetric providers, anesthesia professionals, nursing staff members, and sterile processing department members. Read More

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http://dx.doi.org/10.1002/aorn.12746DOI Listing
August 2019
3 Reads

Standardization and reproducibility of sonographic stomach position grades in fetuses with congenital diaphragmatic hernia.

J Clin Ultrasound 2019 Nov 16;47(9):513-517. Epub 2019 Jul 16.

Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.

Objectives: The purpose of this study was to evaluate the reproducibility of stomach position grading in congenital diaphragmatic hernia (CDH) as proposed by Cordier et al and Basta et al after standardization of the methods at our center.

Methods: We collected sonographic images from 23 fetuses with left-sided CDH at our center from 2010 to 2018. Nine operators (one maternal fetal medicine expert and eight sonographers) reviewed the selected images and graded the stomach position according to the methods of Cordier et al and Basta et al. Read More

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http://dx.doi.org/10.1002/jcu.22759DOI Listing
November 2019
3 Reads

A 19-Year-Old Young Man With Breathlessness and Opacity in the Left Hemithorax.

Chest 2019 07;156(1):e1-e4

Department of Pulmonary Medicine and Radio Diagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1016/j.chest.2018.12.030DOI Listing

Imagiological methods for prediction of fetal pulmonary hypoplasia: a systematic review.

J Matern Fetal Neonatal Med 2019 Jul 3:1-10. Epub 2019 Jul 3.

a Life and Health Sciences Research Institute, School of Medicine , University of Minho , Braga , Portugal.

To compare the different imagiological methods for prediction of fetal pulmonary hypoplasia (PH) in general diseases and associated with preterm rupture of membranes (PROM), and congenital diaphragmatic hernia (CDH). According to PRISMA guidelines, all the literature on PH from 1988 to 2018 was reviewed. Twenty-nine articles were selected and analyzed for two- and three- dimensional-ultrasounds (2D and 3D-US) as predictors for the lethal outcome. Read More

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http://dx.doi.org/10.1080/14767058.2019.1636029DOI Listing
July 2019
5 Reads

Inhibition of retinoic acid signaling induces aberrant pericyte coverage and differentiation resulting in vascular defects in congenital diaphragmatic hernia.

Am J Physiol Lung Cell Mol Physiol 2019 09 3;317(3):L317-L331. Epub 2019 Jul 3.

Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

The mortality and morbidity of patients with congenital diaphragmatic hernia (CDH) is primarily caused by treatment-resistant, persistent pulmonary hypertension. Structural vascular changes, exemplified by extensive muscularization, are already present early in gestation, but the origin of these abnormalities is unknown. Understanding the origin of the vascular defects is important to improve treatment modalities. Read More

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http://dx.doi.org/10.1152/ajplung.00104.2018DOI Listing
September 2019
6 Reads

Lung Ultrasound: A New Tool in the Management of Congenital Lung Malformation.

Am J Perinatol 2019 07 25;36(S 02):S99-S105. Epub 2019 Jun 25.

Department of Biomedical Science and Human Oncology, Neonatology and Neonatal Intensive Care Section, University of Bari "Aldo Moro"-Policlinico Hospital, Bari, Italy.

Objective: This study was aimed to evaluate effectiveness of lung ultrasound (LUS) in the management of congenital pulmonary airway malformation and pulmonary sequestration in NICUs.

Study Design: This is a nonconsecutive case series of neonates admitted to the academic NICU of Policlinico of Bari, Italy, from 2010 to 2018, for suspected lung malformations and examined by LUS.

Results: Seven neonates were admitted for suspected pulmonary malformations, four neonates were diagnosed with pulmonary sequestration and three with congenital pulmonary airway malformation either type I (two cases) or type II (one case) according to Adzick classification. Read More

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http://dx.doi.org/10.1055/s-0039-1692131DOI Listing
July 2019
1 Read

Neonatal lung growth in congenital diaphragmatic hernia: evaluation of lung density and mass by pulmonary MRI.

Pediatr Res 2019 11 25;86(5):635-640. Epub 2019 Jun 25.

The Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Outcomes of infants with congenital diaphragmatic hernia (CDH) are primarily dependent on the severity of pulmonary hypoplasia. It is previously unknown whether postnatal lung growth in infants with CDH represents true parenchymal lung growth or merely an expansion in volume of the existing tissue. We hypothesized that lung volume growth in CDH infants will be accompanied by an increase in lung mass and that CDH infants will demonstrate accelerated catch-up growth of the more hypoplastic lung. Read More

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http://dx.doi.org/10.1038/s41390-019-0480-yDOI Listing
November 2019
10 Reads

Associations of Neonatal Noncardiac Surgery with Brain Structure and Neurodevelopment: A Prospective Case-Control Study.

J Pediatr 2019 09 22;212:93-101.e2. Epub 2019 Jun 22.

Department of Pediatrics, University of Melbourne, Melbourne, Australia; Neonatal Medicine, The Royal Children's Hospital, Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Objective: To examine the associations of neonatal noncardiac surgery with newborn brain structure and neurodevelopment at 2 years of age.

Study Design: Infants requiring neonatal noncardiac surgery for congenital diaphragmatic hernia, esophageal atresia, or anterior abdominal wall defect were compared with infants who did not require surgery, matched for sex, gestation at birth, and postmenstrual age at magnetic resonance imaging. Cerebral magnetic resonance imaging was performed at a mean (SD) postmenstrual age of 41. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.05.050DOI Listing
September 2019
8 Reads

Dyspnoea and constipation: rare case of large bowel obstruction secondary to an incarcerated Morgagni hernia.

BMJ Case Rep 2019 Jun 8;12(6). Epub 2019 Jun 8.

Department of Surgery, Cairns Hospital, Cairns North, Queensland, Australia.

Incarcerated diaphragmatic hernias are often challenging to diagnose. Patients often present with non-specific abdominal symptoms, and barring an imaging modality that confirms herniation of intra-abdominal contents, there is no investigation sensitive or specific enough to identify it. It is a rare cause of mechanical bowel obstruction that clinicians should be aware of. Read More

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http://dx.doi.org/10.1136/bcr-2019-229507DOI Listing
June 2019
4 Reads

The effect of congenital diaphragmatic hernia on the development of left-sided heart structures.

Cardiol Young 2019 Jun 6;29(6):813-818. Epub 2019 Jun 6.

Department of Pediatrics, Division of Cardiology, University of VirginiaChildren's Hospital, P.O. Box 800386 Charlottesville, VA 22908,USA.

Introduction: Patients with congenital diaphragmatic hernias often have concomitant congenital heart disease (CHD), with small left-sided cardiac structures as a frequent finding. The goal of this study is to evaluate which left-sided heart structures are affected in neonates with congenital diaphragmatic hernias.

Methods: Retrospective review of neonates between May 2007 and April 2015 with a diagnosis of a congenital diaphragmatic hernia was performed. Read More

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http://dx.doi.org/10.1017/S1047951119000891DOI Listing
June 2019
12 Reads

Ultrasound evaluation of right diaphragmatic eventration and hernia.

Pediatr Radiol 2019 07 28;49(8):1010-1017. Epub 2019 May 28.

Department of Pediatric Surgery, Riley Hospital for Children, Indiana University, Indianapolis, IN, USA.

Background: A hernia is due to a defect in the diaphragm. An eventration is due to a thinned diaphragm with no central muscle. Distinguishing right diaphragmatic hernia from eventration on chest radiographs can be challenging if no bowel loops are herniated above the diaphragm. Read More

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http://dx.doi.org/10.1007/s00247-019-04417-1DOI Listing
July 2019
25 Reads

Aggravation and deliberation over lung herniation.

BMJ Case Rep 2019 May 27;12(5). Epub 2019 May 27.

Pulmonary & Critical Care, US Army Brooke Army Medical Center, Fort Sam Houston, Texas, USA.

A Caucasian woman aged 58 years with history of asthma and surgically repaired congenital diaphragmatic hernia presented to the emergency department (ED) with persistent cough, pleuritic chest pain, shortness of breath, in spite of recent treatment for influenza A virus. On physical examination, a large bulge was protruding from her left posterior thorax. She was found to have a large abnormal radiographic lucency on lateral chest X-ray posterior to the thoracic cavity, confirmed with chest CT to represent a large lung herniation in between the left seventh and eighth ribs. Read More

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http://dx.doi.org/10.1136/bcr-2019-229225DOI Listing
May 2019
19 Reads

History Matters: A 20-Month-Old Child With Cough and Congestion.

Clin Pediatr (Phila) 2019 11 21;58(13):1452-1454. Epub 2019 May 21.

Louisiana State University Health Sciences Center, Shreveport, LA, USA.

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http://dx.doi.org/10.1177/0009922819850484DOI Listing
November 2019
2 Reads

Ventricular Dysfunction, Interdependence, and Mechanical Dispersion in Newborn Infants with Congenital Diaphragmatic Hernia.

Neonatology 2019 14;116(1):68-75. Epub 2019 May 14.

Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom.

Background: Congenital diaphragmatic hernia (CDH) is an important cause of mortality and morbidity in the neonatal period. Pulmonary hypertension and pulmonary hypoplasia are key pathological findings. Cardiac function may also be an important determinant of disease severity, prognostic indicator, and therapeutic target in CDH. Read More

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http://dx.doi.org/10.1159/000499347DOI Listing
May 2020
5 Reads
2.649 Impact Factor

Three-dimensional reconstruction of defects in congenital diaphragmatic hernia: a fetal MRI study.

Ultrasound Obstet Gynecol 2019 Jun;53(6):816-826

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objective: To assess the clinical feasibility and validity of fetal magnetic resonance imaging (MRI)-based three-dimensional (3D) reconstruction to locate, classify and quantify diaphragmatic defects in congenital diaphragmatic hernia (CDH).

Methods: This retrospective study included 46 cases of CDH which underwent a total of 69 fetal MRI scans (65 in-vivo and four postmortem) at the Medical University of Vienna during the period 1 January 2002 to 1 January 2017. Scans were performed between 16 and 38 gestational weeks using steady-state free precession, T2-weighted and T1-weighted sequences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20296
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http://dx.doi.org/10.1002/uog.20296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619026PMC
June 2019
20 Reads