141 results match your criteria Confusional States and Acute Memory Disorders


Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic.

Lancet Psychiatry 2020 May 18. Epub 2020 May 18.

UCL Institute of Mental Health, University College London, London, UK.

Background: Before the COVID-19 pandemic, coronaviruses caused two noteworthy outbreaks: severe acute respiratory syndrome (SARS), starting in 2002, and Middle East respiratory syndrome (MERS), starting in 2012. We aimed to assess the psychiatric and neuropsychiatric presentations of SARS, MERS, and COVID-19.

Methods: In this systematic review and meta-analysis, MEDLINE, Embase, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature databases (from their inception until March 18, 2020), and medRxiv, bioRxiv, and PsyArXiv (between Jan 1, 2020, and April 10, 2020) were searched by two independent researchers for all English-language studies or preprints reporting data on the psychiatric and neuropsychiatric presentations of individuals with suspected or laboratory-confirmed coronavirus infection (SARS coronavirus, MERS coronavirus, or SARS coronavirus 2). Read More

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http://dx.doi.org/10.1016/S2215-0366(20)30203-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234781PMC

Cognitive impairment, clinical symptoms and functional disability in patients emerging from the minimally conscious state.

NeuroRehabilitation 2020 ;46(1):65-74

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.

Background: Although emergence from the minimally conscious state (eMCS) is associated with symptoms including disorientation, memory and attention impairment, restlessness, and significant functional disability, the neurobehavioral profile of eMCS has not been empirically characterized.

Objective: Determine degree of cognitive impairment, presence of clinical symptoms and functional disability at time eMCS in patients with traumatic and non-traumatic brain injury (TBI, nTBI).

Methods: Retrospective observational study of 169 adults (median [interquartile range] age: 51 [29, 62] years; male: 116; TBI: 103) who emerged from MCS based on the Coma Recovery Scale-Revised while in an inpatient Disorders of Consciousness program. Read More

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http://dx.doi.org/10.3233/NRE-192860DOI Listing
January 2020

Acute treatment of psychotic symptoms in a newly diagnosed Lewy body dementia patient with an accelerated titration schedule of rivastigmine and de-escalation of antipsychotics.

BMJ Case Rep 2019 Sep 4;12(9). Epub 2019 Sep 4.

Internal Medicine, Mercy Hospital Iowa City, Iowa City, Iowa, USA.

A 76-year-old man presented with complaints of increased confusion, visual hallucinations and decline in memory. He was admitted to the hospital and started on quetiapine 50 mg daily for symptom management. Shortly after, he was diagnosed with Lewy body dementia and started on rivastigmine, a cholinesterase inhibitor (ChEI), at 1. Read More

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http://dx.doi.org/10.1136/bcr-2019-230193DOI Listing
September 2019
2 Reads

Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats.

J Anesth 2019 06 25;33(3):482-486. Epub 2019 Mar 25.

Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.

The acute neuroinflammatory response to surgery may play a key pathogenic role in postoperative delirium (POD). Here, we investigated the contribution of acute postoperative pain to neuroinflammation and related delirium-like behaviors after surgery in adult and aged rats. Animals were assigned into four groups: control, abdominal surgery, surgery with analgesia using local ropivacaine, and surgery with analgesia using systemic morphine. Read More

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http://dx.doi.org/10.1007/s00540-019-02635-3DOI Listing
June 2019
2 Reads

Restructuring Blank Spaces: The Role of Cognitive-Behavioral Interventions for Two Patients With Post-traumatic Amnesia After Severe Traumatic Brain Injury.

Mil Med 2019 01;184(1-2):e266-e271

Department of Psychiatry, University of Illinois College of Medicine, 912 S. Wood Street, MC 913, Chicago, IL.

Differentiation of symptoms associated with post-traumatic amnesia (PTA) versus post-traumatic stress symptoms (PTSS) following trauma presents many treatment challenges among veterans and active duty service members receiving rehabilitation after traumatic brain injury (TBI). The acute phase of rehabilitation poses difficulties for amnestic individuals that may elicit classic PTA symptoms as well as premorbid PTSS, thereby activating maladaptive cognitions and an increase in agitation and arousal. Historically, explicit learning and memory strategies were considered non-efficacious with amnestic individuals until PTA resolves; therefore, rehabilitation therapies have utilized implicit learning in the initial phases of recovery. Read More

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http://dx.doi.org/10.1093/milmed/usy179DOI Listing
January 2019
11 Reads

Cognitive/affective factors are associated with children's acute posttraumatic stress following pediatric intensive care.

Psychol Trauma 2019 Jan 7;11(1):55-63. Epub 2018 May 7.

Centre of National Research on Disability and Rehabilitation Medicine (CONROD), The University of Queensland.

This study aimed to explore children's experiences and memories of the pediatric intensive care unit (PICU) and identify the relative importance of premorbid, trauma, and cognitive/affective variables associated with acute posttraumatic stress symptoms (PTSS). Participants were 95 children aged 6-16 years admitted to the PICU and their parents. Children completed questionnaires and an interview assessing PTSS, peritrauma affect, and their memory of the admission 3 weeks following discharge. Read More

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http://dx.doi.org/10.1037/tra0000349DOI Listing
January 2019
13 Reads

Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats.

J Anesth 2018 08 3;32(4):506-517. Epub 2018 May 3.

Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.

Purpose: The purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats.

Methods: Adult and aged rats were randomly assigned to one of three groups: control, isoflurane anesthesia alone, and isoflurane anesthesia with abdominal surgery. On either postoperative day 2 (early phase) or 7 (late phase), all rats were tested for trace and context fear memory retention after acquisition of trace fear conditioning. Read More

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http://dx.doi.org/10.1007/s00540-018-2504-xDOI Listing
August 2018
6 Reads

Anteromedial thalamic infarct: a rare presentation.

BMJ Case Rep 2018 May 2;2018. Epub 2018 May 2.

Department of Neurology, Montefiore Hospital and Medical Center, Bronx, New York, USA.

We report a rare presentation of an anteromedial thalamic infarct in a 50-year-old woman with acute onset left eye ptosis, vertical gaze paresis and confusion. MRI identified an acute left anteromedial thalamic infarct with a severe left P1 stenosis. Thalamic infarcts are associated with marked neurobehavioural disturbances with dominant thalamic lesions causing language deficits, verbal perseveration, memory disturbances, abulia and disorientation. Read More

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http://dx.doi.org/10.1136/bcr-2017-223404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935173PMC
May 2018
14 Reads

Tako-tsubo cardiomyopathy with transient global amnesia and cerebellar embolic stroke triggered by existential fear.

Neurol Neurochir Pol 2018 May - Jun;52(3):394-396. Epub 2018 Jan 6.

Rudolfstiftung, Juchgasse 25, A-1030 Wien, Austria. Electronic address:

Background: Embolic stroke is a complication of Tako-Tsubo-cardiomyopathy (TTC), transient left ventricular dysfunction mimicking myocardial infarction without coronary culprit lesion explaining the whole left ventricular dysfunction. Transient global amnesia (TGA) is characterized by sudden onset of anterograde amnesia without compromise of other neurologic functions.

Case Report: A 57 years old female was admitted because of sudden confusion and loss of her memory after emotional stress. Read More

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http://dx.doi.org/10.1016/j.pjnns.2017.12.013DOI Listing
May 2019
20 Reads

Latent class analysis of the multivariate Delirium Index in long-term care settings.

Int Psychogeriatr 2019 01 3;31(1):59-72. Epub 2018 May 3.

St. Mary's Hospital Research Centre,Montreal,Quebec,Canada.

ABSTRACTBackground:A few studies examine the time evolution of delirium in long-term care (LTC) settings. In this work, we analyze the multivariate Delirium Index (DI) time evolution in LTC settings.

Methods: The multivariate DI was measured weekly for six months in seven LTC facilities, located in Montreal and Quebec City. Read More

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http://dx.doi.org/10.1017/S1041610218000510DOI Listing
January 2019
4 Reads

Long-term sequelae of acute respiratory distress syndrome caused by severe community-acquired pneumonia: Delirium-associated cognitive impairment and post-traumatic stress disorder.

J Int Med Res 2018 Jun 2;46(6):2265-2283. Epub 2018 Apr 2.

3 Department of Anesthesiology and Operative Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Objective Delirium in critically ill patients is considered a risk factor for various long-term consequences. We evaluated delirium and associated long-term outcomes in patients with acute respiratory distress syndrome with non-H1N1 and H1N1- associated severe community-acquired pneumonia (sCAP) who had been recommended to take antiviral drugs associated with delirious symptoms as adverse effects. Methods Of 64 patients, 42 survivors (H1N1, 15; non-H1N1, 27) were analyzed regarding the relationship between medication and the duration of delirium in the intensive care unit. Read More

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http://dx.doi.org/10.1177/0300060518762040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023035PMC
June 2018
15 Reads

[Accessory symptoms of schizophrenia: E. Bleuler's concept].

Authors:
N Yu Pyatnitskiy

Zh Nevrol Psikhiatr Im S S Korsakova 2017;117(11):114-121

Mental Health Research Center, Moscow, Russia.

The analysis of E. Bleuler's concept of accessory symptoms of schizophrenia: delusions, hallucinations, depersonalization disorders, splitting of the ego, memory disorders, catatonic symptoms and acute syndromes (manic and melancholic states, acute paranoia, twilight states, clouding of consciousness, confusion, fugues and dipsomania) is presented. The relationship of accessory symptoms with primary and secondary schizophrenic symptoms according to the second concept of E. Read More

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http://dx.doi.org/10.17116/jnevro2017117111114-121DOI Listing
November 2018
21 Reads

Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice.

Exp Anim 2018 May 29;67(2):193-200. Epub 2017 Nov 29.

Department of Anesthesiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

Systemic inflammation induces brain neuronal inflammation, in turn causing acute cognitive disorders. Furthermore, neuronal inflammation is one cause of postoperative cognitive disorder (POCD) and delirium. However, no sufficiently established pharmacological treatment is available for neurocognitive inflammation. Read More

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http://dx.doi.org/10.1538/expanim.17-0102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955751PMC
May 2018
17 Reads

Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient.

Clin Neurol Neurosurg 2018 01 8;164:1-4. Epub 2017 Nov 8.

Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy. Electronic address:

Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.11.006DOI Listing
January 2018
32 Reads

Validation of the 10-Item Orientation Questionnaire: A New Tool for Monitoring Post-Electroconvulsive Therapy Disorientation.

J ECT 2018 03;34(1):21-25

Objectives: Assessment of post-electroconvulsive therapy (ECT) disorientation at a single time point after ECT treatment may prove an effective and clinically useful method for monitoring the severity of disorientation and predicting ECT-induced retrograde amnesia. In this study, we aimed to validate a novel instrument (10-Item Orientation Questionnaire) developed to assess the level of disorientation after ECT.

Methods: Twenty-four depressed inpatients who were prescribed an acute course of ECT were administered the 10-Item Orientation Questionnaire at 30 minutes after ECT and had time to reorientation assessed at 3 time points after ECT (10, 30, and 60 minutes) at ECT treatments 1 to 3. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000455DOI Listing
March 2018
70 Reads

Dementia with Lewy bodies presenting as probable epileptic seizure.

BMJ Case Rep 2017 Sep 27;2017. Epub 2017 Sep 27.

Geriatric Medicine, Eastern Health, Monash University, Victoria, Australia.

We discuss the case of an 83-year-old man admitted to the hospital after losing control of his vehicle due to an unexplained episode of altered consciousness. This occurred on a background of multiple similar episodes associated with acute confusion, superimposed on a gradual cognitive decline spanning 6 years. Organic aetiologies for delirium were excluded and CT and MRI of the brain were negative for cerebrovascular accidents or other epileptogenic foci. Read More

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http://dx.doi.org/10.1136/bcr-2017-221454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747692PMC
September 2017
19 Reads

Post-ICU psychological morbidity in very long ICU stay patients with ARDS and delirium.

J Crit Care 2018 Feb 24;43:88-94. Epub 2017 Aug 24.

Department of Emergency Medicine, J.W. Ruby Memorial Hospital, West Virginia University, Morgantown, WV, USA; Department of Emergency Medicine, Vident Medical Center, East Carolina University, Greenville, NC, USA. Electronic address:

Purpose: We investigated the impact of delirium on illness severity, psychological state, and memory in acute respiratory distress syndrome patients with very long ICU stay.

Materials And Methods: Prospective cohort study in the medical-surgical ICUs of 2 teaching hospitals. Very long ICU stay (>75days) and prolonged delirium (≥40days) thresholds were determined by ROC analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441173086
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http://dx.doi.org/10.1016/j.jcrc.2017.08.034DOI Listing
February 2018
781 Reads
2.191 Impact Factor

Prodromal stage of disease (dementia) with Lewy bodies, how to diagnose in practice?

Geriatr Psychol Neuropsychiatr Vieil 2017 Jun;15(2):196-204

Centre de gériatrie et CM2R Île de France Sud, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France, Université Pierre et Marie Curie et DHU FAST, UMR 8256 (CNRS), Paris, France.

Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder. Read More

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http://dx.doi.org/10.1684/pnv.2017.0675DOI Listing
June 2017
65 Reads

Simultaneous transient global amnesia and right MCA stroke after Valsalva manoeuvre.

BMJ Case Rep 2017 Apr 22;2017. Epub 2017 Apr 22.

Department of Neurology, Hospital Sant Joan Despi Moises Broggi, Sant Joan Despi, Spain.

A 61-year-old man suffered an episode of transient confusion and anterograde amnesia after a Valsalva-related manoeuvre. The MRI diffusion weighted imaging (DWI) sequences showed a left hippocampal and two right parietal lesions that were deemed as acute. The MR angiography disclosed a high-grade stenosis in the right middle cerebral artery as was described by a transcranial colour-coded ultrasound as well. Read More

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http://dx.doi.org/10.1136/bcr-2016-218990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534739PMC
April 2017
24 Reads

What does extinction have to do with confabulation?

Cortex 2017 02 1;87:5-15. Epub 2016 Nov 1.

Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, University of Geneva, Geneva, Switzerland; Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland.

Behaviourally spontaneous confabulation denotes a distinct syndrome consisting of confabulations that patients act upon, disorientation, and amnesia. It corresponds to the stable form of the original Korsakoff syndrome. While the syndrome may also occur in confusional states and degenerative dementia, this article is about the syndrome as it occurs after acute and focal brain damage. Read More

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http://dx.doi.org/10.1016/j.cortex.2016.10.015DOI Listing
February 2017
56 Reads

Major neurocognitive disorder followıng isolated hippocampal ischemıc lesions.

J Neurol Sci 2017 Jan 3;372:496-500. Epub 2016 Nov 3.

Neuropsychology Unit, Neurology Department, Ege University, School of Medicine, İzmir 35100, Turkey.

Background And Purpose: Major cognitive disorder (MND) following vascular events is known as second causes of dementia after Alzheimer's disease (AD). Acute onset MND due to isolated hippocampal infarction has not been recognized as a specific subtype of vascular dementia, and there is no validated criteria for the identification of such cases, either clinically or radiologically.

Results: Among 7200 patients with first-ever ischemic stroke, 22 patients (0. Read More

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http://dx.doi.org/10.1016/j.jns.2016.11.001DOI Listing
January 2017
19 Reads

A Pilot Randomized Controlled Trial of the Feasibility of a Multicomponent Delirium Prevention Intervention Versus Usual Care in Acute Stroke.

J Cardiovasc Nurs 2017 Jan/Feb;32(1):E1-E10

Karen L. Rice, DNS, APRN, ACNS-BC, ANP Nurse Scientist & Director, The Center for Nursing Research, Ochsner Medical Center, New Orleans, Louisiana. Marsha J. Bennett, DNS, APRN, ACRN Professor, Louisiana State University Health Sciences Center, School of Nursing, New Orleans. Linley Berger, MCD, CCC-SLP Speech Language Pathologist, Ochsner Medical Center, New Orleans, Louisiana. Bethany Jennings, MN, APRN, FNP-C Stroke Program Director, Ochsner Medical Center, New Orleans, Louisiana. Lynn Eckhardt, MSN, APRN, GNP-BC Nurse Practitioner, Neurology Clinic, Ochsner Medical Center, New Orleans, Louisiana. Nicole Fabré-LaCoste, PharmD, BCPS, CGP Clinical Pharmacist Residency Program Director, Ochsner Medical Center, New Orleans, Louisiana. David Houghton, MD, MPH Chief, Division of Memory and Movement Disorders, Ochsner Medical Center, New Orleans, Louisiana. Gabriel Vidal, MD Vascular and Interventional Neurologist, Ochsner Medical Center, New Orleans, Louisiana. Toby Gropen, MD Chief, Division of Vascular Neurology, Ochsner Medical Center, New Orleans, Louisiana. Erica Diggs, MD Hospitalist, Division of Internal Medicine, Ochsner Medical Center, New Orleans, Louisiana. Erin Barry, MSN, RN, CNRN Neuro-Critical Care Clinical Nurse Specialist, Ochsner Medical Center, New Orleans, Louisiana. Jennilee St. John, MSN, APRN, AGCNS-BC, CCRN Neuro-Critical Care Clinical Nurse Specialist, Ochsner Medical Center, New Orleans, Louisiana. Sheena Mathew, PharmD Clinical Pharmacist, Ochsner Medical Center, New Orleans, Louisiana. Allison Egger, MPH Biostatistician, Ochsner Medical Center, New Orleans, Louisiana. Stephanie Ryan, DNP, FNP-C Stroke Team Nurse Practitioner, Ochsner Medical Center, New Orleans, Louisiana. Raymond Egger, BSN, RN, CNRN Stroke Central Coordinator, Ochsner Medical Center, New Orleans, Louisiana. David Galarneau, MD Vice Chairman, Department of Psychiatry, Ochsner Medical Center, New Orleans, Louisiana. Kenneth Gaines, MD Director, Ochsner's Neuroscience Institute, Ochsner Medical Center, New Orleans, Louisiana. E. Wesley Ely, MD, MPH Professor of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, and the Veteran's Affairs Geriatric Research Education Clinical Center (GRECC) of the VA Tennessee Valley Healthcare System, Nashville.

Background: Delirium after acute stroke is a serious complication. Numerous studies support a benefit of multicomponent interventions in minimizing delirium-related complications in at-risk patients, but this has not been reported in acute stroke patients. The purpose of this study was to explore the feasibility of conducting a randomized (delirium care) versus usual standardized stroke care (usual care) in reducing delirium in acute stroke. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/JCN.0000000000000356DOI Listing
February 2018
44 Reads

[Delirium: Concepts, Etiology, and Clinical Management].

Fortschr Neurol Psychiatr 2016 Apr 21;84(4):233-44. Epub 2016 Apr 21.

Delirium is a common condition: up to 35 percent of non-ICU- and 80 percent of ICU-patients experience delirium - particularly the elderly suffering from cerebral dysfunction accompanied by acute infection, surgery, or change of medication. Medical staff should be alert for decrease (within hours) of concentration, memory, orientation, and consciousness - especially when agitation appears and symptoms are fluctuating. Vegetative lapses and seizures may complicate the course, in particular in delirium in withdrawal (of alcohol or drugs). Read More

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http://dx.doi.org/10.1055/s-0042-104502DOI Listing
April 2016
17 Reads

Post-traumatic amnesia and confusional state: hazards of retrospective assessment.

J Neurol Neurosurg Psychiatry 2016 10 17;87(10):1068-74. Epub 2016 Feb 17.

The London Independent Hospital, London, UK Barts and The London School of Medicine and Dentistry, QMUL at the Royal London Hospital, London, UK Institute of Neuroscience, University of Lisbon, Lisbon, Portugal.

Retrospective assessment of post-traumatic amnesia (PTA) must take into account factors other than traumatic brain injury (TBI) which may impact on memory both at the time of injury and subsequent to the injury. These include analgesics, anaesthesia required for surgery, and the development of acute or post-traumatic stress disorder. This is relevant in clinical and medicolegal settings. Read More

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http://jnnp.bmj.com/content/early/2016/02/17/jnnp-2015-31219
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http://dx.doi.org/10.1136/jnnp-2015-312193DOI Listing
October 2016
17 Reads

Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same.

Brain Behav Immun 2016 May 8;54:178-193. Epub 2016 Feb 8.

Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Postoperative cognitive dysfunction (POCD) is a debilitating surgical complication, with cardiac surgery patients at particular risk. To gain insight in the mechanisms underlying the higher incidence of POCD after cardiac versus non-cardiac surgery, systemic and central inflammatory changes, alterations in intraneuronal pathways, and cognitive performance were studied after cardiac and abdominal surgery in rats. Male Wistar rats were subjected to ischemia reperfusion of the upper mesenteric artery (abdominal surgery) or the left coronary artery (cardiac surgery). Read More

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http://dx.doi.org/10.1016/j.bbi.2016.02.003DOI Listing
May 2016
38 Reads

Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial.

Lancet Respir Med 2016 Mar 29;4(3):203-12. Epub 2016 Jan 29.

Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT, USA; Psychology Department and Neuroscience Center, Brigham Young University, Provo, UT, USA; Center for Humanizing Critical Care, Intermountain Health Care, Murray, UT, USA.

Background: Delirium is common in mechanically ventilated patients and is associated with cognitive impairment lasting at least 1 year after hospital discharge. Preclinical and observational studies suggest that the use of statins might reduce delirium in intensive care. We assessed whether the pleiotropic effects of statins can reduce delirium in intensive care and decrease subsequent cognitive impairment in a randomised controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600160000
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http://dx.doi.org/10.1016/S2213-2600(16)00005-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792772PMC
March 2016
71 Reads

Evaluation of cumulative cognitive deficits from electroconvulsive therapy.

Br J Psychiatry 2016 Mar 19;208(3):266-70. Epub 2015 Nov 19.

George G. Kirov, MRCPsych, PhD, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff; Laura Owen, MBBCh, Intensive Care Unit, Department of Anaesthetics, Royal Gwent Hospital, Newport; Hazel Ballard, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff; Adele Leighton, MBBCh, Kara Hannigan, RGN, Danielle Llewellyn, BN, Cardiff & Vale University Health Board, Whitchurch Hospital, Cardiff; Valentina Escott-Price, PhD, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff; Maria Atkins, MRCPsych, Cardiff & Vale University Health Board, Whitchurch Hospital, Cardiff, UK.

Background: Electroconvulsive therapy (ECT) is the most effective acute treatment for severe depression, but widely held concerns about memory problems may limit its use.

Aims: To find out whether repeated or maintenance courses of ECT cause cumulative cognitive deterioration.

Method: Analysis of the results of 10 years of cognitive performance data collection from patients who have received ECT. Read More

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http://dx.doi.org/10.1192/bjp.bp.114.158261DOI Listing
March 2016
106 Reads

Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE.

Age Ageing 2015 Nov 13;44(6):1000-5. Epub 2015 Oct 13.

Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

Introduction: Routine cognitive screening for in-patients aged ≥75 years is recommended, but there is uncertainty around how this should be operationalised. We therefore determined the feasibility and reliability of the Abbreviated mental test score (AMTS/10) and its relationship to subjective memory complaint, Montreal Cognitive Assessment (MoCA/30) and informant report in unselected older admissions.

Methods: Consecutive acute general medicine patients aged ≥75 years admitted over 10 weeks (March-May 2013) had AMTS and a question regarding subjective memory complaint (if no known dementia/delirium). Read More

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http://dx.doi.org/10.1093/ageing/afv134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621235PMC
November 2015
29 Reads

Under-detection of delirium and impact of neurocognitive deficits on in-hospital mortality among acute geriatric and medical wards.

Eur J Intern Med 2015 Nov 31;26(9):696-704. Epub 2015 Aug 31.

Scientific Direction, IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Milano, Italy.

Background: Delirium is a neuropsychiatric disorder, triggered by medical precipitants causes. Study aims were to describe the prevalence and impact on in-hospital mortality of delirium identified through ICD-9 codes as well as evidence of neurocognitive deficits demonstrated in a population of older patients admitted to acute medical wards.

Methods: This was a prospective cohort multicenter study of 2521 older patients enrolled in the "Registro Politerapie SIMI (REPOSI)" during the years 2010 and 2012. Read More

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http://dx.doi.org/10.1016/j.ejim.2015.08.006DOI Listing
November 2015
16 Reads

Acute Amnesia due to Isolated Mammillary Body Infarct.

J Stroke Cerebrovasc Dis 2015 Oct 21;24(10):e303-5. Epub 2015 Aug 21.

Department of Neuroradiology, Columbia University Medical Center, New York, NY.

Background: There are limited reports describing acute amnesia after mammillothalamic tract infarction. Furthermore, acute infarction isolated to the mammillary body has never been reported. We present the first case of anterograde amnesia after isolated acute infarction of the mammillary body in a patient without concurrent or prior thalamic or mammillothalamic tract injury. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.06.038DOI Listing
October 2015
20 Reads

Isolated hippocampal infarcts: Vascular and neuropsychological findings.

J Neurol Sci 2015 Sep 9;356(1-2):83-9. Epub 2015 Jun 9.

Stroke Unit, Neurology Department, Ege University, School of Medicine, İzmir 35100, Turkey.

Background And Purpose: The hippocampus plays a role in the verbal and spatial memory processing, learning, and emotions. The purpose of this study was to determine clinical, etiological, and radiological features of isolated hippocampal infarcts.

Methods: We reviewed, 6800 patients with first-ever ischaemic stroke included in our Stroke Registry between 2004 and 2014. Read More

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http://dx.doi.org/10.1016/j.jns.2015.06.011DOI Listing
September 2015
36 Reads

Informant single screening questions for delirium and dementia in acute care--a cross-sectional test accuracy pilot study.

BMC Geriatr 2015 Feb 25;15:17. Epub 2015 Feb 25.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Cognitive impairment often goes undetected in older people in hospital. Efficient screening tools are required to improve detection. To determine diagnostic properties of two separate informant-based single screening questions for cognitive impairment (dementia and delirium) in hospitalised older people. Read More

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http://dx.doi.org/10.1186/s12877-015-0016-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345037PMC
February 2015
28 Reads
2.000 Impact Factor

[Detection of cognitive deficit in a therapist's practice: review of screening scales].

Authors:
M A Kutlubaev

Ter Arkh 2014 ;86(11):135-8

Acute and chronic cognitive impairments quite often complicate visceral diseases. In this connection, it is important for a therapist to know brief scales to screen for cognitive impairments. Tests, such as a six-component screener, a short orientation-memory-concentration test, a short portable mental status questionnaire, Hodkinson's abbreviated mental test (AMT) (AMT-4 and AMT-10), a clock drawing test, and 4 'A's Test (4AT) may be used for the primary assessment of cognitive functions. Read More

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March 2015
17 Reads

Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy.

Cogn Behav Neurol 2014 Dec;27(4):215-21

*Lelie Care Group, Slingedael Korsakoff Center, Rotterdam, The Netherlands †Lelie Care Group, Slingedael Korsakoff Center; and Helmholtz Institute, Utrecht University, Utrecht, The Netherlands ‡Atlant Care Group, Nursing Home Markenhof, Beekbergen, The Netherlands §Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands ∥Epidemiological and Social Psychiatric Research institute (ESPRi), Erasmus University Medical Center, Department of Psychiatry; and Parnassia Psychiatric Institute, Rotterdam, The Netherlands.

Korsakoff syndrome is a chronic form of amnesia resulting from thiamine deficiency. The syndrome can develop from unrecognized or undertreated Wernicke encephalopathy. The intra-individual course of Wernicke-Korsakoff syndrome has not been studied extensively, nor has the temporal progression of gait disturbances and other symptoms of Wernicke encephalopathy. Read More

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http://dx.doi.org/10.1097/WNN.0000000000000041DOI Listing
December 2014
49 Reads

Family reports of medically impaired drivers in Missouri: cognitive concerns and licensing outcomes.

Accid Anal Prev 2015 Jan 16;74:17-23. Epub 2014 Oct 16.

University of Iceland, Civil and Environmental Engineering, Hjardarhagi 2-6, IS-107 Reykjavik, Iceland. Electronic address:

This study investigated reasons why older adults (n=689) were reported to the Driver License Bureau, Missouri Department of Revenue, by family members as potentially unfit to drive with an emphasis on cognitive concerns and associated licensing outcomes. A total of 448 drivers were reported to have some cognitive issue; common symptoms included confusion, memory loss, and becoming lost while driving. Diagnostic labels (Alzheimer's disease (AD), cognitive impairment/dementia, brain injury/insult) were listed for 365 cases. Read More

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http://dx.doi.org/10.1016/j.aap.2014.10.002DOI Listing
January 2015
36 Reads
2 Citations

A Case of Chronic Wernicke's Encephalopathy: A Neuropsychological Study.

Front Psychiatry 2014 27;5:59. Epub 2014 May 27.

Department of Experimental Psychology, Helmholtz Institute, Utrecht University , Utrecht , Netherlands ; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , Netherlands ; Brain Center Rudolf Magnus, Center of Excellence for Rehabilitation Medicine, De Hoogstraat Rehabilitation, University Medical Center Utrecht , Utrecht , Netherlands.

A 54-year-old woman was referred to our Korsakoff Center because of extensive cognitive problems following acute Wernicke's encephalopathy (WE). She had a relatively short history of alcohol abuse and was found lying on the floor in her home by her son. After 5 days without treatment, she was diagnosed with WE in a general hospital. Read More

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http://dx.doi.org/10.3389/fpsyt.2014.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034510PMC
June 2014
47 Reads

Small-cell lung cancer with voltage-gated calcium channel antibody-positive paraneoplastic limbic encephalitis: a case report.

J Med Case Rep 2014 Apr 8;8:119. Epub 2014 Apr 8.

Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Showa-machi, Maebashi, Gunma 371-8511, Japan.

Introduction: Paraneoplastic limbic encephalitis is a rare neurological syndrome and clinically characterized by cognitive dysfunction, memory impairment, seizures and psychiatric symptoms. Paraneoplastic limbic encephalitis is most frequently found in small-cell lung cancer, among various malignancies, and antineuronal antibodies are related to the autoimmune mechanism. We experienced a rare case of a patient with small-cell lung cancer with anti-voltage-gated calcium channel antibody-positive paraneoplastic limbic encephalitis. Read More

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http://dx.doi.org/10.1186/1752-1947-8-119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000153PMC
April 2014
34 Reads

Post-stroke cognitive impairment: high prevalence and determining factors in a cohort of mild stroke.

J Alzheimers Dis 2014 ;40(4):1029-38

Memory Centre, Department of Neurology, University Hospital, University of Burgundy, Stroke Registry, Dijon, France.

Background: Because of the aging population and a rise in the number of stroke survivors, the prevalence of post-stroke cognitive impairment (PSCI) is increasing.

Objective: To identify the factors associated with 3-month PSCI.

Methods: All consecutive stroke patients without pre-stroke dementia, mild cognitive disorders, or severe aphasia hospitalized in the Neurology Department of Dijon, University Hospital, France (November 2010 - February 2012) were included in this prospective cohort study. Read More

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http://dx.doi.org/10.3233/JAD-131580DOI Listing
January 2015
46 Reads

Differential diagnosis considerations of sickness after rapid pressure changes at altitude.

Aviat Space Environ Med 2013 Dec;84(12):1291-4

Naval Medical Center San Diego, San Diego, CA 92134, USA.

Introduction: Aviation has undergone significant advancement over time; despite our best practices, injuries can still occur. Occasionally aviators will suffer from injuries of barotrauma, decompression sickness, or arterial gas embolism. The history and physical examination are important when evaluating the injury and its subsequent treatment. Read More

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http://dx.doi.org/10.3357/asem.3621.2013DOI Listing
December 2013
28 Reads

Delirium and cognitive decline: more than a coincidence.

Authors:
Julius Popp

Curr Opin Neurol 2013 Dec;26(6):634-9

aDivision of Old Age Psychiatry, Department of Psychiatry bDepartment of Clinical Neuroscience, Leenaards Memory Center, University Hospital of Lausanne, Lausanne, Switzerland.

Purpose Of Review: To review the recent findings on the relationships between delirium and cognitive decline in the elderly.

Recent Findings: Current advances in the field include substantial new evidence that delirium increases the risk of dementia in patients without previous cognitive impairment and accelerates cognitive decline in patients with Alzheimer's disease. Findings on cognitive trajectories and domains affected contribute to better understanding of the clinical nature of cognitive impairment after delirium. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000030DOI Listing
December 2013
24 Reads

Chemical submission to commit robbery: a series of involuntary intoxications with flunitrazepam in Asian travellers in Brussels.

J Forensic Leg Med 2013 Oct 24;20(7):918-21. Epub 2013 Aug 24.

Department of Emergency Medicine, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium, Université Libre de Bruxelles (ULB). Electronic address:

Between January 17, 2003 and August 29, 2003, the Emergency Department admitted a patient who had been surreptitiously intoxicated and robbed of his valuables every Friday. The first cases were considered anecdotal, but criminal activity was rapidly suspected. The cohort includes 16 male Asian patients aged 28-50 years. Read More

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http://dx.doi.org/10.1016/j.jflm.2013.06.017DOI Listing
October 2013
26 Reads

[Secondary benefits of cognitive rehabilitation for a chronic ethylic patient: effects on disorder consciousness, motivation, and global therapeutic cooperation].

Encephale 2014 Jun 5;40(3):263-70. Epub 2013 Aug 5.

Unité Alzheimer, service de psychiatrie-II, centre mémoire, centre hospitalier Princesse-Grace, avenue Pasteur, 98000 Monaco, Monaco.

Introduction: Alcoholism causes psychological, behavioral and cognitive symptoms that need to be addressed together. The neuropsychological alterations among alcohol-dependent people are considered to make the therapeutic work complex and longer. A cognitive rehabilitation program is sometimes difficult to achieve with these patients. Read More

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http://dx.doi.org/10.1016/j.encep.2013.03.007DOI Listing
June 2014
21 Reads

Acute confusional migraine: a variant not to be missed.

BMJ Case Rep 2013 Aug 2;2013. Epub 2013 Aug 2.

Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

A middle age woman who had frequent migraines was admitted with memory loss following severe unilateral headache, restlessness and confusion. Investigations including haematology, biochemistry, cerebrospinal fluid analysis serology and imaging were normal. As she had frequent migraines with a history of ophthalmoplegic migraine, acute confusional migraine was thought of as a possibility. Read More

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http://casereports.bmj.com/content/2013/bcr-2013-010504.full
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http://casereports.bmj.com/cgi/doi/10.1136/bcr-2013-010504
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http://dx.doi.org/10.1136/bcr-2013-010504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761691PMC
August 2013
21 Reads

Post-traumatic amnesia.

J Clin Neurosci 2013 Nov 20;20(11):1475-81. Epub 2013 Jun 20.

Department of Neurosurgery, Institute of Surgery, IMB 20, P.O. Box 670, The Townsville Hospital, Douglas, Townsville, QLD 4810, Australia; School of Medicine and Dentistry, James Cook University, Douglas, Townsville, QLD 4810, Australia. Electronic address:

Of patients hospitalised for traumatic brain injury (TBI), most pass through a state of altered consciousness known as "post-traumatic amnesia" (PTA). Despite the lack of a consistent definition, PTA is widely used as a construct in neurosurgical practice to guide decision-making and prognosis. Accurate PTA assessment is important, because over-evaluation leads to excess social, financial and opportunity costs, whilst under-evaluation risks patient welfare. Read More

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http://dx.doi.org/10.1016/j.jocn.2012.11.022DOI Listing
November 2013
52 Reads
1.318 Impact Factor

The neuropsychological sequelae of delirium in elderly patients with hip fracture three months after hospital discharge.

Int Psychogeriatr 2013 Sep 7;25(9):1521-31. Epub 2013 May 7.

Department of Geriatric Medicine, Medical Center Alkmaar, Alkmaar, the Netherlands.

Background: Delirium is a risk factor for long-term cognitive impairment and dementia. Yet, the nature of these cognitive deficits is unknown as is the extent to which the persistence of delirium symptoms and presence of depression at follow-up may account for the association between delirium and cognitive impairment at follow-up. We hypothesized that inattention, as an important sign of persistent delirium and/or depression, is an important feature of the cognitive profile three months after hospital discharge of patients who experienced in-hospital delirium. Read More

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http://dx.doi.org/10.1017/S1041610213000574DOI Listing
September 2013
40 Reads

Assessing the performance of the four question abbreviated mental test in the acute geriatric setting.

Acute Med 2013 ;12(1):13-7

Sheffield Teaching Hospitals, UK.

Background: NCognitive impairment is common amongst acute geriatric hospital admissions but detection is often poor and this is associated with worse outcomes. The four-question abbreviated mental test (AMT4) has previously been promoted nationally in the acute setting as a succinct assessment tool. However, a recent national dementia Commissioning for Quality and Innovation (CQUIN) goal recommends a single screening question followed by the tenquestion abbreviated mental test (AMT10). Read More

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September 2013
23 Reads

What is the lowest threshold to make a diagnosis of concussion?

Br J Sports Med 2013 Apr;47(5):268-71

Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria 3084, Australia.

Objective: The purpose of this review is to examine the evidence for determining the lowest threshold for diagnosing a sport-related concussion.

Data Sources: MEDLINE, CINAHL, EMBASE, Mosby's Index, PsycEXTRA, PsycINFO and Scopus. Key words included sports concussion, concussion assessment, diagnosis, concussion symptoms, onfield assessment and sports-related traumatic brain injury. Read More

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http://dx.doi.org/10.1136/bjsports-2013-092247DOI Listing
April 2013
36 Reads

[Paraneoplastic limbic encephalitis: 2 pediatric cases].

Arch Pediatr 2013 Apr 6;20(4):386-90. Epub 2013 Mar 6.

Unité d'onco-hématologie pédiatrique, service de pédiatrie, CHU de Saint-Étienne, avenue Albert-Raymond, 42055 Saint-Étienne cedex 2, France.

The term "paraneoplastic neurologic disorders" refers to a group of syndromes mediated by immune responses triggered by tumors that express neuronal proteins or by immunological disturbances caused by the tumor. In most cases, limbic encephalitis is a disorder of adulthood, particularly in association with small-cell lung cancer or a testicular germ-cell tumor. The clinical picture of this disorder includes anxiety, depression, confusion, delirium, hallucinations, short-term memory loss and sometimes seizures. Read More

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http://dx.doi.org/10.1016/j.arcped.2013.01.009DOI Listing
April 2013
14 Reads

Effect of rosuvastatin on cytokines after traumatic head injury.

J Neurosurg 2013 Mar 4;118(3):669-75. Epub 2013 Jan 4.

Department of Clinical Epidemiology, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, México.

Object: The favorable effect of statin treatment after traumatic brain injury (TBI) has been shown in animal studies and is probably true in humans as well. The objective of this study was to determine whether acute statin treatment following TBI could reduce inflammatory cytokines and improve functional outcomes in humans.

Methods: The authors performed a double-blind randomized clinical trial in patients with moderate to severe TBI. Read More

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http://dx.doi.org/10.3171/2012.12.JNS121084DOI Listing
March 2013
35 Reads

[Gamma-hydroxybutyrate (GHB) and its lactone (GBL) as psychoactive substances].

Przegl Lek 2012 ;69(8):544-7

Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej.

Gammabutyrolactone is included in the solvent such as wheel cleaners, pesticides, cosmetics, drugs. After ingestion GBL is converted to gamma-hydroxybutyrate. Both substances are classified as so called "club drugs" and their action is characterized by euphoria, sedation, and induction of retrograde amnesia of events. Read More

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January 2013
42 Reads