5,619 results match your criteria Condyloma Acuminatum


Verrucous carcinoma arising in a long standing Buschke-Löwenstein tumor.

Clin Case Rep 2019 Apr 19;7(4):836-838. Epub 2019 Feb 19.

Joan C Edwards School of Medicine, Edwards Comprehensive Cancer Center Marshall University Huntington West Virginia.

Giant condyloma acuminatum is a rare variant of genital warts also known as Buschke-Löwenstein tumor. It is characterized by a slow progression of exophytic, ulcerative, and cauliflower-shaped tumor with benign histological features. Verrucous carcinoma however is a rare variant of well-differentiated squamous cell carcinoma with limited metastatic potential. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452454PMC
April 2019
1 Read

Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts.

J Dermatolog Treat 2019 Apr 16:1-20. Epub 2019 Apr 16.

a Shandong Provincial Institute of Dermatology and Venereology , Jinan , Shandong , China.

Background: Condylomata acuminata(CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1594670DOI Listing
April 2019
1 Read

A pregnant woman with condyloma acuminatum on the vaginal orifice, areola, groin, and umbilicus.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):310-312

Infectious Disease Center, Peking University Ditan Teaching Hospital; Department of Dermatology and Venereology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.

Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital, perianal squamous mucosa, and skin. CA outside the anogenital region is not common. Here, we report a case showing simultaneous presence of CA on the vaginal orifice, areola, groin, and umbilicus in a 32-year-old pregnant woman. Read More

View Article

Download full-text PDF

Source
http://www.ijpmonline.org/text.asp?2019/62/2/310/255829
Publisher Site
http://dx.doi.org/10.4103/IJPM.IJPM_518_18DOI Listing
April 2019
8 Reads

Interferon Alpha 2a and 2b in Ophthalmology: A Review.

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/jir.2018.0125
Publisher Site
http://dx.doi.org/10.1089/jir.2018.0125DOI Listing
April 2019
3 Reads

5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras/Raf/MEK/ERK and PI3K/AKT pathways in HeLa cells.

J Photochem Photobiol B 2019 Mar 21;194:46-55. Epub 2019 Mar 21.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Human papillomavirus (HPV) infection is linked to several diseases, the most prominent of which are cervical cancer and genital condyloma acuminatum. Previous studies have suggested an effective role for 5-aminolevulinic acid photodynamic therapy (ALA-PDT) against various cancers by the induction of autophagy and apoptosis. However, few reports have focused on the effectiveness of ALA-PDT on HPV related disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2019.03.012DOI Listing
March 2019
1 Read
2.960 Impact Factor

Perianal giant condyloma Acuminatum-Buschke-Löwenstein tumor.

Presse Med 2019 Mar 22. Epub 2019 Mar 22.

Mohammed the First University of Oujda, Mohammed 6 University Hospital of Oujda-Medical School of Oujda, Department of Dermatology, Oujda, Morocco; Mohammed the First University of Oujda, Laboratory of Epidemiology, Medical School of Oujda, Clinical Research and Public Health, Oujda, Morocco.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2019.02.021DOI Listing
March 2019
1 Read
1.173 Impact Factor

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.

Int J Hyperthermia 2019 26;36(1):383-393. Epub 2019 Mar 26.

a Graduate School, China Medical University , Shenyang , China.

Background: Hyperthermia has proved successful in treating cutaneous human papillomavirus infectious diseases such as plantar wart and condyloma acuminata (CA). Moreover, this treatment provides improved therapeutic efficacy in these conditions as compared with conventional therapies.

Objectives: To investigate the global proteome changes in CA in response to hyperthermia and achieve a better understanding of the mechanisms of hyperthermia therapy against HPV-infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02656736.2019.1578420DOI Listing
March 2019
1 Read

Comparative analysis of human papillomavirus type 6 complete genomes originated from head and neck and anogenital disorders.

Infect Genet Evol 2019 Mar 21;71:140-150. Epub 2019 Mar 21.

Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. Electronic address:

It is increasingly recognized that fundamental differences exist between high-risk and low-risk human papillomavirus (HPV) genotypes regarding interactions with the host. This study aims to join the recently emerging efforts to uncover these differences at the complete genome level and to study how they may influence the disease caused. Sixteen samples of thirteen patients with various HPV6-mediated benign mucosal disorders (nine recurrent respiratory papillomatoses with 2-8 recurrences, one condyloma acuminatum and three premalignant lesions of the genital mucosa) were sampled to determine the complete virus genomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.03.019DOI Listing
March 2019
1 Read

Cross-sectional study estimating the psychosocial impact of genital warts and other anogenital diseases in South Korea.

BMJ Open 2019 Mar 20;9(3):e025035. Epub 2019 Mar 20.

School of Medicine, Ewha Womans University, Seoul, South Korea.

Objectives: To estimate self-reported human papillomavirus (HPV) disease-related psychosocial impact among male and female patients in South Korea.

Design: In this multicentre cross-sectional study, psychosocial impacts were estimated using a one-time survey capturing HPV Impact Profile (HIP) results, CuestionarioEspecifico en Condilomas Acuminados (CECA; in Spanish)-'Specific questionnaire for Condylomata Acuminata' and the EuroQol-5 Dimension (EQ-5D) surveys. Student's t-tests or Mann-Whitney U tests were used for continuous comparisons; χ or Fisher's exact tests were applied for categorical comparisons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025035DOI Listing
March 2019
2 Reads

Macrophages participate in the immunosuppression of condyloma acuminatum through the PD-1 /PD-L1 signalling pathway.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Background: The aim of this study was to investigate whether macrophages can participate in the immunosuppression of condyloma acuminatum (CA) by expressing PD-1/PD-L1.

Methods: The infiltration of macrophages and expression of programmed death-1 (PD-1) and PD-1 ligand 1 (PD-L1) on wart lesions and in normal skin tissues were detected by immunohistochemistry assay. The amounts of M1 and M2 type macrophages derived from THP-1 cells were measured by flow cytometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCMA.0000000000000090DOI Listing
March 2019
1 Read

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy center.

J Eur Acad Dermatol Venereol 2019 Mar 18. Epub 2019 Mar 18.

Interdisciplinary HIV center (IZAR), University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.

Background: Incidence of anal carcinoma is increased in people living with HIV (PLWH). Due to the improved life expectancy in PLWH, identifying appropriate prevention strategies for non-AIDS defining cancer types such as anal carcinoma has become a priority in managing PLWH today.

Objective: We aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and/or carcinoma in PLWH, regardless of gender or sexual orientation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15575DOI Listing
March 2019
2 Reads

What is the most relevent factor during ALA-PDT? A multi-center, open clinical pain score research about actinic keratosis, acne and condylomatata acuminata.

Photodiagnosis Photodyn Ther 2019 Mar 2. Epub 2019 Mar 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, School of Medicine, Shanghai, China. Electronic address:

Background: To date, it has been reported that the intrinsic factors(lesions location, lesions area, disease types) and extrinsic factors(fluence rate) contribute to the pain during 5-aminolevulinic acid photodynamic therapy (ALA-PDT). But there are few studies on pain during ALA-PDT and lack of sufficient clinical evidence related to the pain intensity.

Objective: To investigate pain intensity and its relative factors during ALA-PDT and to provide clinical implication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2019.03.001DOI Listing
March 2019
2 Reads

Recalcitrant extragenital giant condyloma acuminatum: A need for combination therapy.

Dermatol Ther 2019 Mar 5:e12867. Epub 2019 Mar 5.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Giant condyloma acuminatum (GCA), also known as Buschke -Löwenstein tumor, is a huge, rapidly growing variant of condyloma found in the anogenital region. Extragenital GCA is rare and, in most cases, affecting the intertriginous area and treated by excision. We described a case of refractory extragenital GCA involving the large part of the left axilla area successfully treated with immunotherapy and podophyllotoxin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12867DOI Listing
March 2019
2 Reads

Expression of Wnt-1 and TSLC1 in condyloma acuminatum.

Clin Exp Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Despite its high contagiousness, high recurrence rate and potential for malignant transformation, effective treatments for condyloma acuminatum (CA) have not yet been developed. Accordingly, it is necessary to clarify the mechanisms underlying CA development.

Aim: To investigate the expression and significance of the proteins Wnt-1 and TSLC1 in patients with CA and in normal foreskin controls. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ced.13862
Publisher Site
http://dx.doi.org/10.1111/ced.13862DOI Listing
February 2019
7 Reads

Genital Warts.

Authors:
Dara Grennan

JAMA 2019 02;321(5):520

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2018.20181DOI Listing
February 2019
2 Reads

Treatment of multi-position condyloma acuminatum using topical CO laser combined with photodynamic therapy - Report of 6 cases.

Photodiagnosis Photodyn Ther 2019 Mar 29;25:436-439. Epub 2019 Jan 29.

Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Condyloma acuminatum(CA) is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is also an effective therapy which targets on HPV infected sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2019.01.030DOI Listing
March 2019
2 Reads

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study.

Salud Publica Mex 2018 Nov-Dic;60(6):633-644

Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute.Tampa, Florida.

Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs.

Materials And Methods: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21149/8461DOI Listing
December 2016
9 Reads

HPV-Related Papillary Lesions of the Oral Mucosa: A Review.

Authors:
Sasha J Betz

Head Neck Pathol 2019 Mar 29;13(1):80-90. Epub 2019 Jan 29.

Division of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-019-01003-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405797PMC
March 2019
11 Reads

Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.

Sex Transm Infect 2019 02 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

View Article

Download full-text PDF

Source
http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053606
Publisher Site
http://dx.doi.org/10.1136/sextrans-2018-053606DOI Listing
February 2019
7 Reads

[Advancement in phodynamic therapy for non-neoplastic skin diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1380-1383

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.016DOI Listing
December 2018
2 Reads

Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women.

BMC Infect Dis 2019 Jan 7;19(1):27. Epub 2019 Jan 7.

Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.

Methods: We enrolled 1020 women in a prospective cohort study in Nigeria and followed them for a mean (SD) of 9 (4) months. Nurses conducted pelvic examinations and collected ectocervical samples for HPV testing. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3582-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323853PMC
January 2019
15 Reads
2.613 Impact Factor

Treatment of condyloma acuminatum using the combination of laser ablation and ALA-PDT.

Photodiagnosis Photodyn Ther 2019 Mar 20;25:193-196. Epub 2018 Dec 20.

Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address:

Background: Human papilloma virus (HPV) infection and condyloma acuminatum (CA) in the genital area often exist in extensive and multi-point fashion. Laser ablation combined with topical photodynamic therapy (PDT) is a feasible approach for genital CA but its effectiveness and limitations need to be evaluated.

Methods: This single-arm prospective study consisted of 100 newly diagnosed CA cases of both sexes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2018.12.006DOI Listing
March 2019
21 Reads

Condyloma Acuminata Presenting as Isolated Papillary Lesions in the Prostatic Urethra.

Am J Case Rep 2018 Dec 22;19:1522-1525. Epub 2018 Dec 22.

Department of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

BACKGROUND A condyloma acuminatum is a sexually transmitted, human papillomavirus (HPV) associated, neoplasm. In men, it is predominantly found on external genitalia and rarely progresses more proximally than the distal penile urethra. Condyloma acuminata of the prostatic urethra are rare and are usually seen as an extension of, or in association with external lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.911682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320550PMC
December 2018
5 Reads

Extensive anogenital warts: a multidisciplinary surgical management.

Pan Afr Med J 2018 26;30:227. Epub 2018 Jul 26.

Department of Urology-Oncology, "Theageneio" Cancer Hospital of Thessaloniki, Thessaloniki, Greece.

Genital warts are a major worldwide healthcare problem of sexually active population. Apart from direct association with cervical cancer, male patients experience HPV-related condylomata in several locations in the anogenital area. Extensive growth, multifocality and difficult accessibility wart sites are demanding and often require multidisciplinary surgical management. Read More

View Article

Download full-text PDF

Source
http://www.panafrican-med-journal.com/content/article/30/227
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.227.16448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295299PMC
January 2019
5 Reads

Coexistence of genital lichen sclerosus and genital warts.

Acta Dermatovenerol Alp Pannonica Adriat 2018 12;27(4):221-223

Department of Dermatology and Venereology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of the genital and extragenital skin. Anogenital warts are benign proliferative lesions caused by human papillomavirus (HPV), which is found in > 95% of lesions. We present two cases of the coexistence of LS and genital warts: one patient with and one without a previous history of genital warts. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Recurrent oral squamous papilloma in a pediatric patient: Case report and review of the literature.

Niger J Clin Pract 2018 Dec;21(12):1674-1677

Department of Oral and Maxillofacial Pathology/Biology, Lagos University Teaching Hospital, Lagos, Nigeria.

Squamous papillomas are common lesions of the oral mucosa. They are benign proliferating lesions often painless, slow growing and with a cauliflower appearance. However, its clinical appearance which sometimes mimics exophytic carcinoma, verrucous carcinoma or condyloma acuminatum raises concern when it occurs in the oral cavity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/njcp.njcp_407_17DOI Listing
December 2018
1 Read

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
7 Reads

Squamous cell carcinoma of the anal canal.

Curr Probl Cancer 2018 09 23;42(5):486-492. Epub 2018 Nov 23.

Brigham and Women's Hospital, Boston, Massachusetts.

Anal squamous cell carcinoma (SCC) is a rare cancer and accounts for approximately 4% of all cancers of the lower alimentary tract. The dominant etiology is infection with human papilloma virus (HPV), which is the most common sexually transmitted disease in the United States. Integration of HPV DNA into the host genome seems to be the driving mechanism behind carcinogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.currproblcancer.2018.11.001DOI Listing
September 2018
5 Reads

Ingenol mebutate for the treatment of anogenital condylomata acuminata.

Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.13840DOI Listing
November 2018
1 Read

Perspective clinical study on effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating condylomata acuminata in pregnancy.

Photodiagnosis Photodyn Ther 2019 Mar 14;25:63-65. Epub 2018 Nov 14.

Department of Dermatology of the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China.

Objective: To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulval condylomata acuminata (CA) in pregnancy.

Methods: The clinical efficacies of ALA-PDT on 16 cases of CA in pregnancy as well as cryotherapy on 22 cases of CA in pregnancy were analyzed in this prospective study.

Results: The treatment group showed a wart clearance rate of 93. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2018.11.012DOI Listing
March 2019
4 Reads

5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus.

J Dermatolog Treat 2018 Nov 14:1-18. Epub 2018 Nov 14.

a Department of Dermatology and Venereology , Nanfang hospital, Southern Medical University , Guangzhou , 510515 , China.

Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
Publisher Site
http://dx.doi.org/10.1080/09546634.2018.1544406DOI Listing
November 2018
20 Reads

[Research progression of prophylactic HPV vaccine application].

Authors:
L Zhang F H Zhao

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):724-728

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Prophylactic HPV vaccine was a milestone in the prevention and control of HPV-related diseases, especially cervical cancer. The first HPV vaccine has been marketed in the world for more than 10 years. The follow-up study of HPV vaccine clinical trials further confirms the effectiveness and safety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.10.002DOI Listing
October 2018
2 Reads

A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment.

J Drugs Dermatol 2018 Oct;17(10):1100-1105

Background: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Read More

View Article

Download full-text PDF

Source
October 2018
13 Reads

[HPV infection in women : Diagnostics, treatment and the relevance of vaccination].

Urologe A 2018 Dec;57(12):1445-1451

Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Str. 22, 81765, München, Deutschland.

Background: Benign, premalignant and malignant changes in the anogenital region, as in the oropharynx are often affected by a persistent HPV infection. Since a causal therapy isn't possible, the focus is on early diagnosis of dysplasia. Better knowledge of the human papilloma virus led to the development of the HPV vaccine and now primary prevention of cancer is possible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00120-018-0795-zDOI Listing
December 2018
6 Reads

Extragenital condyloma acuminatum in the left axillary vault.

JAAD Case Rep 2018 Oct 11;4(9):947-949. Epub 2018 Oct 11.

Division of Dermatology, Washington University School of Medicine, St Louis, Missouri.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2018.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191947PMC
October 2018
5 Reads

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function.

Exp Ther Med 2018 Nov 3;16(5):3909-3912. Epub 2018 Sep 3.

Department of Dermatology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.6676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176148PMC
November 2018
3 Reads

Treatment of giant condyloma acuminatum of the anus. State of the art.

Ann Ital Chir 2018 ;89:291-294

Giant condyloma acuminatum (GCA) is a rare cauliflower-like lesion, also known as Buschke-L ewenstein tumor (BLT). Although characterized by benign histological features, the local behavior of GCA is extremely aggressive, showing progressive infiltration of the surrounding structures leading to tissue destruction by compression. As the correlation between HPV and GCA development grew stronger, the majority of the Authors came to the conclusion that HPV can not only cause CA but, associated with particular risk factors, it can lead to much more serious conditions such as BLT. Read More

View Article

Download full-text PDF

Source
January 2018
3 Reads

Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report.

Transplant Proc 2018 Oct 20;50(8):2553-2557. Epub 2018 Mar 20.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00411345183044
Publisher Site
http://dx.doi.org/10.1016/j.transproceed.2018.02.182DOI Listing
October 2018
9 Reads

Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing.

Eur J Med Res 2018 Sep 28;23(1):45. Epub 2018 Sep 28.

Department of Dermatology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Background: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40001-018-0343-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161468PMC
September 2018
6 Reads

Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men.

Ger Med Sci 2018 13;16:Doc03. Epub 2018 Aug 13.

Epidemiology, QuintilesIMS, Frankfurt, Germany.

The goal of this retrospective analysis was to study the prevalence and treatment of the most common sexually transmitted infections (STI) in men followed by urologists in Germany. This study included a total of 347,090 men followed in 71 urology practices in Germany between 2013 and 2015. The first outcome was the prevalence of individuals diagnosed with STI between 2013 and 2015. Read More

View Article

Download full-text PDF

Source
http://www.egms.de/en/journals/gms/2018-16/000265.shtml
Publisher Site
http://dx.doi.org/10.3205/000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124731PMC
January 2019
6 Reads

Photodynamic therapy as an alternative therapeutic option for pediatric condyloma acuminata: A case series.

Photodiagnosis Photodyn Ther 2018 12 20;24:179-181. Epub 2018 Sep 20.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2018.09.010DOI Listing
December 2018
4 Reads

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.

R Soc Open Sci 2018 Aug 29;5(8):172376. Epub 2018 Aug 29.

Department of Dermatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People's Republic of China.

The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell proliferation and apoptosis, to determine a novel therapeutic target for CA recurrence. RT-qPCR was used to validate the lower expression of miR-143 and miR-145 in a larger size of CA samples, and the expression of NRAS in CA samples was significantly higher than self-controls as determined by western blotting assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsos.172376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124073PMC
August 2018
5 Reads

5-aminolevulinic acid photodynamic therapy for anal canal condyloma acuminatum: A series of 19 cases and literature review.

Photodiagnosis Photodyn Ther 2018 Sep 6;23:230-234. Epub 2018 Jul 6.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2018.06.022DOI Listing
September 2018
5 Reads
2.010 Impact Factor

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region.

Authors:
May P Chan

Arch Pathol Lab Med 2018 Sep 11. Epub 2018 Sep 11.

From the Department of Pathology, University of Michigan Health System, Ann Arbor.

Context: - Histologic distinction between condyloma acuminatum and various benign and malignant condyloma-like lesions in the anogenital area poses a common diagnostic challenge to pathologists across subspecialties.

Objective: - To review the overlapping and distinguishing features of condyloma acuminatum and its mimics, and to clarify confusing terminology and diagnostic criteria for problematic entities.

Data Sources: - A review of the literature on condyloma acuminatum (ordinary and giant types), verrucous carcinoma, warty/warty-basaloid high-grade squamous intraepithelial lesion and squamous cell carcinoma, papillary squamous cell carcinoma, bowenoid papulosis, verruca vulgaris, epidermolytic acanthoma, and verruciform xanthoma was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2018-0039-RADOI Listing
September 2018
11 Reads

Successful treatment of giant condyloma in a pediatric heart transplant recipient with topical cidofovir.

Transpl Infect Dis 2018 Dec 28;20(6):e12989. Epub 2018 Sep 28.

Department of Pediatrics, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas.

We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following 7 months of topical cidofovir, without evidence of systemic toxicity or rejection. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/tid.12989
Publisher Site
http://dx.doi.org/10.1111/tid.12989DOI Listing
December 2018
35 Reads

Multimodality Imaging Review of Anorectal and Perirectal Diseases With Histological, Endoscopic, and Operative Correlation, Part I: Anatomy and Neoplasms.

Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.

Department of Radiology, Louisiana State University Health Shreveport, Shreveport, LA.

A broad spectrum of pathology affects the rectum, anus, and perineum and understanding of its relevant anatomy is important in accurate reporting, particularly in rectal cancer. In this pictorial essay, correlative imaging, endoscopic, pathologic, and operative images are presented to illustrate normal anorectal anatomy and neoplastic conditions that affect the anus and rectum. A particular case-based focus is given to rectal adenocarcinoma with pelvic MR and surgical histopathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1067/j.cpradiol.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401326PMC
July 2018
27 Reads

The role of regulatory T cells in pathogenesis and therapy of human papillomavirus-related diseases, especially in cancer.

Infect Genet Evol 2018 11 29;65:406-413. Epub 2018 Aug 29.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Human papillomavirus (HPV) is the most common sexually transmitted agent in the world. It can cause condyloma acuminatum, anogenital malignancies, and head and neck cancers. The host immune responses to HPV involve multiple cell types that have regulatory functions, and HPV-mediated changes to regulatory T cells (Tregs) in both the local lesion tissues and the circulatory system of patients have received considerable attention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2018.08.014DOI Listing
November 2018
9 Reads

[Clinicopathological features and management of penile verrucous carcinoma].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2. Read More

View Article

Download full-text PDF

Source
November 2018
20 Reads

Treatment of intraurethral condylomata acuminata with surgery and cidofovir instillations in two immunocompromised patients and review of the literature.

Antiviral Res 2018 Oct 25;158:238-243. Epub 2018 Aug 25.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Condylomata acuminata (CA) or anogenital warts are benign proliferative lesions caused by low-risk human papillomaviruses (HPV). Treating CA can be very frustrating for patients and clinicians due to the high recurrence rates. Immunosuppression is associated with larger size of CA that are more frequently resistant to treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2018.08.016DOI Listing
October 2018
27 Reads

Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission.

J Infect Dis 2019 Jan;219(2):275-283

Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston.

Background: Condylomata acuminata (anogenital warts [AGWs]) are prevalent in human immunodeficiency virus (HIV)-infected individuals and sexually active populations at risk for HIV acquisition and have been associated with HIV transmission. We compared AGW specimens to control tissue specimens for abundance, types, and location of HIV target cells and for susceptibility to HIV infection in vitro, to provide biologic evidence that AGWs facilitate HIV transmission.

Methods: We used immunohistologic staining to identify HIV target cells in AGW and control specimens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiy505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306021PMC
January 2019
13 Reads