5,521 results match your criteria Condyloma Acuminata


Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: a report of two cases.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.003DOI Listing
February 2019
1 Read

Genital Warts.

Authors:
Dara Grennan

JAMA 2019 02;321(5):520

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http://dx.doi.org/10.1001/jama.2018.20181DOI Listing
February 2019

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study.

Salud Publica Mex 2018 Nov-Dic;60(6):633-644

Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute.Tampa, Florida.

Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs.

Materials And Methods: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. Read More

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http://dx.doi.org/10.21149/8461DOI Listing
December 2016
2 Reads

[Advancement in phodynamic therapy for non-neoplastic skin diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1380-1383

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.016DOI Listing
December 2018
1 Read

Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women.

BMC Infect Dis 2019 Jan 7;19(1):27. Epub 2019 Jan 7.

Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.

Methods: We enrolled 1020 women in a prospective cohort study in Nigeria and followed them for a mean (SD) of 9 (4) months. Nurses conducted pelvic examinations and collected ectocervical samples for HPV testing. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3582-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323853PMC
January 2019
5 Reads
2.613 Impact Factor

Condyloma Acuminata Presenting as Isolated Papillary Lesions in the Prostatic Urethra.

Am J Case Rep 2018 Dec 22;19:1522-1525. Epub 2018 Dec 22.

Department of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

BACKGROUND A condyloma acuminatum is a sexually transmitted, human papillomavirus (HPV) associated, neoplasm. In men, it is predominantly found on external genitalia and rarely progresses more proximally than the distal penile urethra. Condyloma acuminata of the prostatic urethra are rare and are usually seen as an extension of, or in association with external lesions. Read More

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http://dx.doi.org/10.12659/AJCR.911682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320550PMC
December 2018
4 Reads

Extensive anogenital warts: a multidisciplinary surgical management.

Pan Afr Med J 2018 26;30:227. Epub 2018 Jul 26.

Department of Urology-Oncology, "Theageneio" Cancer Hospital of Thessaloniki, Thessaloniki, Greece.

Genital warts are a major worldwide healthcare problem of sexually active population. Apart from direct association with cervical cancer, male patients experience HPV-related condylomata in several locations in the anogenital area. Extensive growth, multifocality and difficult accessibility wart sites are demanding and often require multidisciplinary surgical management. Read More

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http://www.panafrican-med-journal.com/content/article/30/227
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http://dx.doi.org/10.11604/pamj.2018.30.227.16448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295299PMC
January 2019
4 Reads

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
5 Reads

Dowling-Degos Disease Localized on Vulva Mimicking Condyloma Acuminata.

Indian J Dermatol 2018 Nov-Dec;63(6):521-522

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.4103/ijd.IJD_10_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233035PMC
December 2018
6 Reads

Ingenol mebutate for the treatment of anogenital condylomata acuminata.

Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/ced.13840DOI Listing
November 2018
1 Read

Perspective Clinical Study on Effect of 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) in Treating Condylomata Acuminata in Pregnancy.

Photodiagnosis Photodyn Ther 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology of the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China.

Objective: To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulval condylomata acuminata (CA) in pregnancy.

Methods: The clinical efficacies of ALA-PDT on 16 cases of CA in pregnancy as well as cryotherapy on 22 cases of CA in pregnancy were analyzed in this prospective study.

Results: The treatment group showed a wart clearance rate of 93. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.11.012DOI Listing
November 2018
2 Reads

[Research progression of prophylactic HPV vaccine application].

Authors:
L Zhang F H Zhao

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):724-728

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Prophylactic HPV vaccine was a milestone in the prevention and control of HPV-related diseases, especially cervical cancer. The first HPV vaccine has been marketed in the world for more than 10 years. The follow-up study of HPV vaccine clinical trials further confirms the effectiveness and safety. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.10.002DOI Listing
October 2018
1 Read

A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment.

J Drugs Dermatol 2018 Oct;17(10):1100-1105

Background: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Read More

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October 2018
7 Reads

[HPV infection in women : Diagnostics, treatment and the relevance of vaccination].

Urologe A 2018 Dec;57(12):1445-1451

Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Str. 22, 81765, München, Deutschland.

Background: Benign, premalignant and malignant changes in the anogenital region, as in the oropharynx are often affected by a persistent HPV infection. Since a causal therapy isn't possible, the focus is on early diagnosis of dysplasia. Better knowledge of the human papilloma virus led to the development of the HPV vaccine and now primary prevention of cancer is possible. Read More

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http://dx.doi.org/10.1007/s00120-018-0795-zDOI Listing
December 2018
5 Reads

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report.

SAGE Open Med Case Rep 2018 10;6:2050313X18802143. Epub 2018 Oct 10.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X18802143
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http://dx.doi.org/10.1177/2050313X18802143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180360PMC
October 2018
9 Reads

Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report.

Transplant Proc 2018 Oct 20;50(8):2553-2557. Epub 2018 Mar 20.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183044
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http://dx.doi.org/10.1016/j.transproceed.2018.02.182DOI Listing
October 2018
7 Reads

Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing.

Eur J Med Res 2018 Sep 28;23(1):45. Epub 2018 Sep 28.

Department of Dermatology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Background: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes. Read More

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http://dx.doi.org/10.1186/s40001-018-0343-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161468PMC
September 2018
5 Reads

Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men.

Ger Med Sci 2018 13;16:Doc03. Epub 2018 Aug 13.

Epidemiology, QuintilesIMS, Frankfurt, Germany.

The goal of this retrospective analysis was to study the prevalence and treatment of the most common sexually transmitted infections (STI) in men followed by urologists in Germany. This study included a total of 347,090 men followed in 71 urology practices in Germany between 2013 and 2015. The first outcome was the prevalence of individuals diagnosed with STI between 2013 and 2015. Read More

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http://www.egms.de/en/journals/gms/2018-16/000265.shtml
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http://dx.doi.org/10.3205/000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124731PMC
January 2019
5 Reads

Photodynamic therapy as an alternative therapeutic option for pediatric condyloma acuminata: A case series.

Photodiagnosis Photodyn Ther 2018 12 20;24:179-181. Epub 2018 Sep 20.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2018.09.010DOI Listing
December 2018
2 Reads

5-aminolevulinic acid photodynamic therapy for anal canal condyloma acuminatum: A series of 19 cases and literature review.

Photodiagnosis Photodyn Ther 2018 Sep 6;23:230-234. Epub 2018 Jul 6.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.06.022DOI Listing
September 2018
2 Reads
2.010 Impact Factor

Successful treatment of giant condyloma in a pediatric heart transplant recipient with topical cidofovir.

Transpl Infect Dis 2018 Dec 28;20(6):e12989. Epub 2018 Sep 28.

Department of Pediatrics, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas.

We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following 7 months of topical cidofovir, without evidence of systemic toxicity or rejection. Read More

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http://doi.wiley.com/10.1111/tid.12989
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http://dx.doi.org/10.1111/tid.12989DOI Listing
December 2018
25 Reads

Multimodality Imaging Review of Anorectal and Perirectal Diseases With Histological, Endoscopic, and Operative Correlation, Part I: Anatomy and Neoplasms.

Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.

Department of Radiology, Louisiana State University Health Shreveport, Shreveport, LA.

A broad spectrum of pathology affects the rectum, anus, and perineum and understanding of its relevant anatomy is important in accurate reporting, particularly in rectal cancer. In this pictorial essay, correlative imaging, endoscopic, pathologic, and operative images are presented to illustrate normal anorectal anatomy and neoplastic conditions that affect the anus and rectum. A particular case-based focus is given to rectal adenocarcinoma with pelvic MR and surgical histopathology. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.07.015DOI Listing
July 2018
16 Reads

[Clinicopathological features and management of penile verrucous carcinoma].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2. Read More

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November 2018
19 Reads

Treatment of intraurethral condylomata acuminata with surgery and cidofovir instillations in two immunocompromised patients and review of the literature.

Antiviral Res 2018 Oct 25;158:238-243. Epub 2018 Aug 25.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Condylomata acuminata (CA) or anogenital warts are benign proliferative lesions caused by low-risk human papillomaviruses (HPV). Treating CA can be very frustrating for patients and clinicians due to the high recurrence rates. Immunosuppression is associated with larger size of CA that are more frequently resistant to treatment. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.08.016DOI Listing
October 2018
17 Reads

Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission.

J Infect Dis 2019 Jan;219(2):275-283

Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston.

Background: Condylomata acuminata (anogenital warts [AGWs]) are prevalent in human immunodeficiency virus (HIV)-infected individuals and sexually active populations at risk for HIV acquisition and have been associated with HIV transmission. We compared AGW specimens to control tissue specimens for abundance, types, and location of HIV target cells and for susceptibility to HIV infection in vitro, to provide biologic evidence that AGWs facilitate HIV transmission.

Methods: We used immunohistologic staining to identify HIV target cells in AGW and control specimens. Read More

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http://dx.doi.org/10.1093/infdis/jiy505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306021PMC
January 2019
11 Reads

Human Papillomavirus-Associated Invasive Condylomas in a Man with Immunosuppressive Comorbidities.

Urol Int 2018 Aug 21:1-5. Epub 2018 Aug 21.

Department of Urology and Pediatric Urology, Saarland University, Homburg, Germany.

Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present the case of a 77-year-old Caucasian male with enormous genital warts of the penis, scrotum, groins and anus. Lesions were excised by electrosurgery. Read More

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http://dx.doi.org/10.1159/000491098DOI Listing
August 2018
23 Reads

Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.

Oncol Lett 2018 Sep 18;16(3):3241-3247. Epub 2018 Jun 18.

Department of Dermatology, Tianjin Union Medical Center, Tianjin 300121, P.R. China.

The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly increased caspase-3 and caspase-9 activities, induced B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein, tumor protein 53 and cyclin-dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV-18(+) cervical cancer cells. Read More

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http://dx.doi.org/10.3892/ol.2018.8983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096279PMC
September 2018
4 Reads

Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial.

Clin Exp Obstet Gynecol 2018 ;45(3):383-386

Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM.

Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Read More

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http://www.irog.net
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http://dx.doi.org/10.12891/ceog4112.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075835PMC
August 2018
13 Reads

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men.

PLoS One 2018 1;13(8):e0199033. Epub 2018 Aug 1.

Department of Surgery, University Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain.

Background: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men.

Aim: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice.

Methods: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199033PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070186PMC
January 2019
5 Reads

Successful treatment of penile condyloma acuminata accompanied with lichen planus with photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Dec 29;24:142-144. Epub 2018 Jul 29.

Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:

Condyloma acuminata and lichen planus are different cutaneous diseases with disparate etiologies. Simultaneous appearance of two diseases in the same area is rare. This report aims to share the clinical and pathological features of a rare case; introduce an effective and safe therapy of it so as to broaden the therapeutic spectrum of Photodynamic Therapy (PDT) indications. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2017.09.015DOI Listing
December 2018
4 Reads

Imiquimod-induced hypopigmentation following treatment of periungual verruca vulgaris.

Cutis 2018 Jun;101(6):466-468

Bay Pines VA Healthcare System, St. Petersburg, Florida, USA.

Imiquimod is a topical immunomodulating medication approved by the US Food and Drug Administration for the treatment of condyloma acuminata, actinic keratoses (AKs), and superficial basal cell carcinoma (BCC). Imiquimod commonly is used off label for its antiviral and antitumoral effects. We present a case of a 51-year-old man with vitiligolike depigmentation following treatment of periungual verruca vulgaris with imiquimod therapy. Read More

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June 2018
1 Read

Treatment of latent or subclinical Genital HPV Infection with 5-aminolevulinic acid-based photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Sep 23;23:362-364. Epub 2018 Jul 23.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Background: Genital HPV infections are widely prevalent. HPV can persist and be transmitted to partners even after warts are gone. The HPV genotype and viral load assay can reveal whether infections are persistent or latent, and it can serve as a predictor of infection clearance. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.07.014DOI Listing
September 2018
2 Reads

[A young man with extensive skin abnormalities].

Ned Tijdschr Geneeskd 2018 May 16;162. Epub 2018 May 16.

GGD Flevoland, Centrum Seksuele Gezondheid, Lelystad.

A 26-year-old man who has sex with men visited the STI clinic because of increasing skin abnormalities since four months. The patient had macular skin lesions on his penis and scrotum, condylomata lata in the anal region, cutaneous lesions on the feet, and a widespread papular rash. A secondary stage of syphilis was diagnosed. Read More

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May 2018
2 Reads

Development of a human papillomavirus type 6/11 vaccine candidate for the prevention of condyloma acuminatum.

Vaccine 2018 08 2;36(32 Pt B):4927-4934. Epub 2018 Jul 2.

Departments of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. Electronic address:

Condyloma acuminatum (CA) represents a significant human papillomavirus (HPV) disease burden worldwide, resulting in substantial healthcare costs and loss of life quality in both genders. To address this problem, we tried to develop a bivalent HPV6/11 virus-like particle (VLP) vaccine targeting CA. HPV6/11 VLPs were generated in Hansenula polymorpha, and a disassembly and reassembly (D/R) treatment was further conducted to improve the stability and monodispersity of the VLPs. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.06.041DOI Listing
August 2018
8 Reads

[Treatment of HPV-associated Anal Lesions in HIV-positive Patients - Comparison of Surgical Treatment and Topical Therapy with Imiquimod].

Zentralbl Chir 2018 Jul 3. Epub 2018 Jul 3.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Objectives: In HIV-patients, routine proctological assessment is warranted due to the high incidence of human papilloma virus (HPV) infection-related anogenital lesions, such as Condylomata acuminata (C. ac.), anal intraepithelial dysplasia (AIN) and anal cancer. Read More

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http://dx.doi.org/10.1055/a-0632-2017DOI Listing
July 2018
22 Reads

Anogenital warts in children: Analysis of a cohort of 34 prepubertal children.

Pediatr Dermatol 2018 Sep 1;35(5):e325-e327. Epub 2018 Jul 1.

Department of Dermatovenereology, Centro Hospitalar de São João, EPE, Porto, Portugal.

Anogenital warts are caused by infection with the human papillomavirus. We reviewed the clinical data of 34 children younger than 13 with anogenital warts referred to the department of dermatovenereology of a tertiary care hospital. Suspicion of sexual abuse was raised in 11 (32. Read More

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http://dx.doi.org/10.1111/pde.13543DOI Listing
September 2018
18 Reads

[Pigmented extramammary Paget's disease accompanied with condyloma acuminatum: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Jun;50(3):572-575

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis. Read More

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June 2018
11 Reads

A comparative study of two techniques in the treatment of condyloma acuminata.

Ann Ital Chir 2018 ;89:455-460

Objectives: Condyloma acuminata (CA) is mainly caused by human papillomavirus (HPV) types 6 and 11. Clinicians use many different methods to treat analcondyloma acuminate ( CA). In this study, we aimed to compare electrocautery ablation (ECA) and argon plasma coagulation (APC) techniques in terms of postoperative bleeding, pain, scar development, loss of sexual sensation, and recurrence rates. Read More

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January 2018
35 Reads

DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes.

J Dermatol Sci 2018 Sep 23;91(3):256-267. Epub 2018 May 23.

China Medical University, Shenyang, 110001, China; Department of Dermatology, No.1 Hospital of China Medical University, China; Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, 110001, China. Electronic address:

Background: Hyperthermia is an effective treatment against cancer and human papillomavirus (HPV) infection. Previous studies have shown that heat shock proteins are crucial to the action of hyperthermia.

Objectives: To examine the effects of hyperthermia in combination with DNAJA4-deficiency on human keratinocytes and Condyloma acumunatum (CA) tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183023
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http://dx.doi.org/10.1016/j.jdermsci.2018.05.006DOI Listing
September 2018
8 Reads

Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial.

Dis Colon Rectum 2018 Jul;61(7):824-829

Department of Surgery, University of Vermont Medical Center, Burlington, Vermont.

Background: Postoperative pain is a frequent cause for delayed discharge following outpatient procedures, including anorectal surgery. Both central and peripheral pain receptor sensitization are thought to contribute to postoperative pain. Blocking these receptors and preempting sensitization prevents hyperalgesia leading to lower pain medication requirements. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001069DOI Listing
July 2018
11 Reads

Perianal condyloma acuminatum-like plaque.

Cutis 2018 Apr;101(4):248;255;256;259

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, USA.

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April 2018
3 Reads

The Impact of Varying Numbers of Quadrivalent Human Papillomavirus Vaccine Doses on Anogenital Warts in the United States: A Database Study.

J Low Genit Tract Dis 2018 Jul;22(3):189-194

Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, TX.

Objective: The aim of the study was to investigate the effects of 3 or less quadrivalent human papillomavirus (HPV) vaccine doses on anogenital warts in both males and females in the United States.

Materials And Methods: We conducted a retrospective database study that included males and females aged 9 to 26 years who received varying numbers of vaccine doses between 2006 and 2015. The primary outcome was the incidence of anogenital warts starting 3 months after the last dose of the HPV vaccine. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014903PMC
July 2018
10 Reads

Invasive penile squamous cell carcinoma.

Cutis 2018 Mar;101(3):224-227

Department of Laboratory Medicine, Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.

Invasive penile squamous cell carcinoma (PSCC) is a rare malignancy with considerable morbidity and mortality. Because a delayed or incorrect diagnosis can have a devastating outcome, physicians should maintain a high index of clinical suspicion for PSCC in patients presenting with penile lesions, particularly in young or middle-aged patients in whom presentation of PSCC is uncommon. We report the case of a 27-year-old circumcised man who presented with invasive PSCC following a diagnosis of condyloma 8 years prior. Read More

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March 2018
4 Reads

Prevalence and Burden Related to Genital Warts in India.

Viral Immunol 2018 06 2;31(5):346-351. Epub 2018 May 2.

8 Royal Women's Hospital , Melbourne, Australia .

The prevalence of genital warts (GW) and self-reported human papillomavirus (HPV) as well as disease-related psychosocial impact among male and female patients aged 18-60 years in India were assessed. GW prevalence was estimated using a 2-week daily log of patients examined from June 7-September 22, 2011 by 200 participating physicians in 6 regions of India. Psychosocial impact was estimated using one-time, self-administered surveys, including HPV Impact Profile (HIP), Cuestionario Específico para Condiloma Acuminado ([Spanish] CECA; "Specific questionnaire for Condylomata Acuminata") and EuroQol-5 Dimension survey. Read More

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http://dx.doi.org/10.1089/vim.2017.0157DOI Listing
June 2018
20 Reads

Prevalence, incidence and correlates of low risk HPV infection and anogenital warts in a cohort of women living with HIV in Burkina Faso and South Africa.

PLoS One 2018 1;13(5):e0196018. Epub 2018 May 1.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objective: To report the prevalence and incidence of low-risk human papillomavirus infection (LR-HPV) and anogenital warts (AGW) among women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA), and to explore HIV-related factors associated with these outcomes.

Methods: We enrolled 1238 WLHIV (BF = 615; SA = 623) aged 25-50 years and followed them at three time points (6, 12 and 16 months) after enrolment. Presence of AGW was assessed during gynaecological examination. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196018PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929550PMC
July 2018
12 Reads

Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.

Medicine (Baltimore) 2018 Apr;97(16):e0329

Department of Public Health and Infectious Diseases.

Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity. Read More

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http://dx.doi.org/10.1097/MD.0000000000010329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916677PMC
April 2018
9 Reads

Optical techniques for the diagnosis and treatment of lesions induced by the human papillomavirus - A resource letter.

Photodiagnosis Photodyn Ther 2018 Sep 11;23:106-110. Epub 2018 Apr 11.

Federal Medical Center, Butner North Carolina, 27509, USA.

Human papillomaviruses (HPV) are the most common sexually-transmitted virus, and carcinogenic HPV strains are reported to be responsible for virtually all cases of cervical cancer and its precursor, the cervical intraepithelial neoplasia (CIN). About 30% of the sexually active population are considered to be affected by HPV. Around 600 million people are estimated to be infected worldwide. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.04.004DOI Listing
September 2018
6 Reads

100 years of STIs in the UK: a review of national surveillance data.

Sex Transm Infect 2018 12 13;94(8):553-558. Epub 2018 Apr 13.

Public Health England, London, UK.

Objectives: The 1916 Royal Commission on Venereal Diseases was established in response to epidemics of syphilis and gonorrhoea in the UK. In the 100 years since the Venereal Diseases Act (1917), the UK has experienced substantial scientific, economic and demographic changes. We describe historical and recent trends in STIs in the UK. Read More

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http://dx.doi.org/10.1136/sextrans-2017-053273DOI Listing
December 2018
28 Reads

Giant anorectal condyloma acuminatum of Buschke-Löwenstein presents difficult management decisions.

J Surg Case Rep 2018 Apr 3;2018(4):rjy058. Epub 2018 Apr 3.

University Medical Center Health System, Timothy J. Harnar Burn Center, Lubbock, TX 79415, USA.

Condyloma acuminata, or anogenital warts, caused by human papillomavirus are the most common sexually transmitted disease. In rare cases, the disease could progress to an extensive neoplasm called Buschke-Löwenstein tumor (BLT), also known as giant condyloma acuminatum. BLT differs from normal condyloma acuminata by presenting with locally invasive growth, lack of spontaneous resolution, tendency for recurrence after treatment and potential for malignant transformation. Read More

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http://dx.doi.org/10.1093/jscr/rjy058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888221PMC
April 2018
27 Reads

Application of dermoscopy image analysis technique in diagnosing urethral condylomata acuminata.

An Bras Dermatol 2018 Jan-Feb;93(1):67-71

Department of Dermatology of First Affiliated Hospital of PLA General Hospital - Beijing, China.

Background: In this study, cases with suspected urethral condylomata acuminata were examined by dermoscopy, in order to explore an effective method for clinical.

Objective: To study the application of dermoscopy image analysis technique in clinical diagnosis of urethral condylomata acuminata.

Methods: A total of 220 suspected urethral condylomata acuminata were clinically diagnosed first with the naked eyes, and then by using dermoscopy image analysis technique. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871365PMC
April 2018
14 Reads