5,535 results match your criteria Condyloma Acuminata


Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts.

J Dermatolog Treat 2019 Apr 16:1-20. Epub 2019 Apr 16.

a Shandong Provincial Institute of Dermatology and Venereology , Jinan , Shandong , China.

Background: Condylomata acuminata(CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts. Read More

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http://dx.doi.org/10.1080/09546634.2019.1594670DOI Listing
April 2019
1 Read

Interferon Alpha 2a and 2b in Ophthalmology: A Review.

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0125
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http://dx.doi.org/10.1089/jir.2018.0125DOI Listing
April 2019
3 Reads

Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata

Asian Pac J Cancer Prev 2019 Mar 26;20(3):943-949. Epub 2019 Mar 26.

Department of Dermatology-Venereology, Faculty of Medicine, Udayana University-Sanglah General Hospital, Bali, Indonesia. Email:

Background: Condyloma acuminata is a type of human papilloma virus (HPV) infection in the anogenital area and often associated with immunosuppressive conditions, such as human immunodeficiency virus (HIV). Low plasma zinc levels could cause alteration of cellular immunity, leading to reduction of interleukin-2 (IL-2) and interferon-γ (IFN-γ), cytokines required for inhibition of HPV replication. Moreover, low plasma zinc levels could cause disruption of apoptotic regulation, results in the unimpeded proliferation of epithelial cells infected with HPV. Read More

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http://journal.waocp.org/article_84935.html
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http://dx.doi.org/10.31557/APJCP.2019.20.3.943DOI Listing
March 2019
2 Reads

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.

Int J Hyperthermia 2019 26;36(1):383-393. Epub 2019 Mar 26.

a Graduate School, China Medical University , Shenyang , China.

Background: Hyperthermia has proved successful in treating cutaneous human papillomavirus infectious diseases such as plantar wart and condyloma acuminata (CA). Moreover, this treatment provides improved therapeutic efficacy in these conditions as compared with conventional therapies.

Objectives: To investigate the global proteome changes in CA in response to hyperthermia and achieve a better understanding of the mechanisms of hyperthermia therapy against HPV-infectious diseases. Read More

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http://dx.doi.org/10.1080/02656736.2019.1578420DOI Listing
March 2019
1 Read

Cross-sectional study estimating the psychosocial impact of genital warts and other anogenital diseases in South Korea.

BMJ Open 2019 Mar 20;9(3):e025035. Epub 2019 Mar 20.

School of Medicine, Ewha Womans University, Seoul, South Korea.

Objectives: To estimate self-reported human papillomavirus (HPV) disease-related psychosocial impact among male and female patients in South Korea.

Design: In this multicentre cross-sectional study, psychosocial impacts were estimated using a one-time survey capturing HPV Impact Profile (HIP) results, CuestionarioEspecifico en Condilomas Acuminados (CECA; in Spanish)-'Specific questionnaire for Condylomata Acuminata' and the EuroQol-5 Dimension (EQ-5D) surveys. Student's t-tests or Mann-Whitney U tests were used for continuous comparisons; χ or Fisher's exact tests were applied for categorical comparisons. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025035DOI Listing
March 2019
2 Reads

Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy center.

J Eur Acad Dermatol Venereol 2019 Mar 18. Epub 2019 Mar 18.

Interdisciplinary HIV center (IZAR), University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.

Background: Incidence of anal carcinoma is increased in people living with HIV (PLWH). Due to the improved life expectancy in PLWH, identifying appropriate prevention strategies for non-AIDS defining cancer types such as anal carcinoma has become a priority in managing PLWH today.

Objective: We aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and/or carcinoma in PLWH, regardless of gender or sexual orientation. Read More

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http://dx.doi.org/10.1111/jdv.15575DOI Listing
March 2019
2 Reads

[Condyloma acuminata].

Rev Prat 2018 Apr;68(4):406

Service de dermatologie, CHU Mohamed VI d'Oujda Laboratoire d'épidémiologie, de santé publique et de recherche scientifique, Oujda, Maroc.

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Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis.

Oncologist 2019 Mar 6. Epub 2019 Mar 6.

Division of Hematology/Oncology, Georgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University Medical Center, Washington, D.C., USA.

Background: Juvenile-onset recurrent respiratory papillomatosis (JO-RRP) is a human papilloma virus-mediated progressive benign neoplasm that affects children and young adults. Primary management consists of regular surgical debulking to maintain airway patency and vocal function. Like condyloma acuminata, JO-RRP is associated with immune dysregulation, and T cells isolated from papillomas express an anergic phenotype. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0505DOI Listing
March 2019
3 Reads

What is the most relevent factor during ALA-PDT? A multi-center, open clinical pain score research about actinic keratosis, acne and condylomatata acuminata.

Photodiagnosis Photodyn Ther 2019 Mar 2. Epub 2019 Mar 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, School of Medicine, Shanghai, China. Electronic address:

Background: To date, it has been reported that the intrinsic factors(lesions location, lesions area, disease types) and extrinsic factors(fluence rate) contribute to the pain during 5-aminolevulinic acid photodynamic therapy (ALA-PDT). But there are few studies on pain during ALA-PDT and lack of sufficient clinical evidence related to the pain intensity.

Objective: To investigate pain intensity and its relative factors during ALA-PDT and to provide clinical implication. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.03.001DOI Listing
March 2019
2 Reads

Treatment with Radix Euphorbiae Ebracteolatae significantly decreases the expression of E6 and L1, and increases the expression of p53 and Rb in HPV18-infected human foreskin keratinocytes.

Curr Mol Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Dermatology, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, 528 Zhang Heng Road, Pudong New Area District, Shanghai 201203. China.

Background: Radix Euphorbiae Ebracteolatae (REE) was recently reported to be significantly superior to vitamin A acid ointment in treating multiple plantar warts. However, effects of REE on HPV18 remain unclear. Therefore, the current study aimed to investigate effects of REE on the proliferation of HPV18, and explore possible molecular mechanisms underlying the effects. Read More

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http://dx.doi.org/10.2174/1566524019666190226102713DOI Listing
February 2019
1 Read
3.621 Impact Factor

Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: A report of two cases.

Photodiagnosis Photodyn Ther 2019 Mar 6;25:460-462. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.003DOI Listing
March 2019
1 Read

Genital Warts.

Authors:
Dara Grennan

JAMA 2019 02;321(5):520

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http://dx.doi.org/10.1001/jama.2018.20181DOI Listing
February 2019
2 Reads

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study.

Salud Publica Mex 2018 Nov-Dic;60(6):633-644

Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute.Tampa, Florida.

Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs.

Materials And Methods: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. Read More

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http://dx.doi.org/10.21149/8461DOI Listing
December 2016
9 Reads

Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.

Sex Transm Infect 2019 02 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053606
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http://dx.doi.org/10.1136/sextrans-2018-053606DOI Listing
February 2019
7 Reads

[Advancement in phodynamic therapy for non-neoplastic skin diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1380-1383

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.016DOI Listing
December 2018
2 Reads

Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women.

BMC Infect Dis 2019 Jan 7;19(1):27. Epub 2019 Jan 7.

Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.

Methods: We enrolled 1020 women in a prospective cohort study in Nigeria and followed them for a mean (SD) of 9 (4) months. Nurses conducted pelvic examinations and collected ectocervical samples for HPV testing. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3582-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323853PMC
January 2019
15 Reads
2.613 Impact Factor

Condyloma Acuminata Presenting as Isolated Papillary Lesions in the Prostatic Urethra.

Am J Case Rep 2018 Dec 22;19:1522-1525. Epub 2018 Dec 22.

Department of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

BACKGROUND A condyloma acuminatum is a sexually transmitted, human papillomavirus (HPV) associated, neoplasm. In men, it is predominantly found on external genitalia and rarely progresses more proximally than the distal penile urethra. Condyloma acuminata of the prostatic urethra are rare and are usually seen as an extension of, or in association with external lesions. Read More

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http://dx.doi.org/10.12659/AJCR.911682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320550PMC
December 2018
5 Reads

Extensive anogenital warts: a multidisciplinary surgical management.

Pan Afr Med J 2018 26;30:227. Epub 2018 Jul 26.

Department of Urology-Oncology, "Theageneio" Cancer Hospital of Thessaloniki, Thessaloniki, Greece.

Genital warts are a major worldwide healthcare problem of sexually active population. Apart from direct association with cervical cancer, male patients experience HPV-related condylomata in several locations in the anogenital area. Extensive growth, multifocality and difficult accessibility wart sites are demanding and often require multidisciplinary surgical management. Read More

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http://www.panafrican-med-journal.com/content/article/30/227
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http://dx.doi.org/10.11604/pamj.2018.30.227.16448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295299PMC
January 2019
5 Reads

Coexistence of genital lichen sclerosus and genital warts.

Acta Dermatovenerol Alp Pannonica Adriat 2018 12;27(4):221-223

Department of Dermatology and Venereology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of the genital and extragenital skin. Anogenital warts are benign proliferative lesions caused by human papillomavirus (HPV), which is found in > 95% of lesions. We present two cases of the coexistence of LS and genital warts: one patient with and one without a previous history of genital warts. Read More

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December 2018
1 Read

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
7 Reads

Dowling-Degos Disease Localized on Vulva Mimicking Condyloma Acuminata.

Indian J Dermatol 2018 Nov-Dec;63(6):521-522

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.4103/ijd.IJD_10_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233035PMC
December 2018
13 Reads

Ingenol mebutate for the treatment of anogenital condylomata acuminata.

Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/ced.13840DOI Listing
November 2018
1 Read

Perspective clinical study on effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating condylomata acuminata in pregnancy.

Photodiagnosis Photodyn Ther 2019 Mar 14;25:63-65. Epub 2018 Nov 14.

Department of Dermatology of the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China.

Objective: To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulval condylomata acuminata (CA) in pregnancy.

Methods: The clinical efficacies of ALA-PDT on 16 cases of CA in pregnancy as well as cryotherapy on 22 cases of CA in pregnancy were analyzed in this prospective study.

Results: The treatment group showed a wart clearance rate of 93. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.11.012DOI Listing
March 2019
4 Reads

[Research progression of prophylactic HPV vaccine application].

Authors:
L Zhang F H Zhao

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):724-728

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Prophylactic HPV vaccine was a milestone in the prevention and control of HPV-related diseases, especially cervical cancer. The first HPV vaccine has been marketed in the world for more than 10 years. The follow-up study of HPV vaccine clinical trials further confirms the effectiveness and safety. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.10.002DOI Listing
October 2018
2 Reads

A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment.

J Drugs Dermatol 2018 Oct;17(10):1100-1105

Background: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Read More

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October 2018
13 Reads

[HPV infection in women : Diagnostics, treatment and the relevance of vaccination].

Urologe A 2018 Dec;57(12):1445-1451

Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Str. 22, 81765, München, Deutschland.

Background: Benign, premalignant and malignant changes in the anogenital region, as in the oropharynx are often affected by a persistent HPV infection. Since a causal therapy isn't possible, the focus is on early diagnosis of dysplasia. Better knowledge of the human papilloma virus led to the development of the HPV vaccine and now primary prevention of cancer is possible. Read More

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http://dx.doi.org/10.1007/s00120-018-0795-zDOI Listing
December 2018
6 Reads

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report.

SAGE Open Med Case Rep 2018 10;6:2050313X18802143. Epub 2018 Oct 10.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X18802143
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http://dx.doi.org/10.1177/2050313X18802143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180360PMC
October 2018
17 Reads

Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report.

Transplant Proc 2018 Oct 20;50(8):2553-2557. Epub 2018 Mar 20.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183044
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http://dx.doi.org/10.1016/j.transproceed.2018.02.182DOI Listing
October 2018
9 Reads

Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing.

Eur J Med Res 2018 Sep 28;23(1):45. Epub 2018 Sep 28.

Department of Dermatology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Background: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes. Read More

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http://dx.doi.org/10.1186/s40001-018-0343-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161468PMC
September 2018
6 Reads

Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men.

Ger Med Sci 2018 13;16:Doc03. Epub 2018 Aug 13.

Epidemiology, QuintilesIMS, Frankfurt, Germany.

The goal of this retrospective analysis was to study the prevalence and treatment of the most common sexually transmitted infections (STI) in men followed by urologists in Germany. This study included a total of 347,090 men followed in 71 urology practices in Germany between 2013 and 2015. The first outcome was the prevalence of individuals diagnosed with STI between 2013 and 2015. Read More

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http://www.egms.de/en/journals/gms/2018-16/000265.shtml
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http://dx.doi.org/10.3205/000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124731PMC
January 2019
6 Reads

Photodynamic therapy as an alternative therapeutic option for pediatric condyloma acuminata: A case series.

Photodiagnosis Photodyn Ther 2018 12 20;24:179-181. Epub 2018 Sep 20.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2018.09.010DOI Listing
December 2018
4 Reads

5-aminolevulinic acid photodynamic therapy for anal canal condyloma acuminatum: A series of 19 cases and literature review.

Photodiagnosis Photodyn Ther 2018 Sep 6;23:230-234. Epub 2018 Jul 6.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.06.022DOI Listing
September 2018
5 Reads
2.010 Impact Factor

Successful treatment of giant condyloma in a pediatric heart transplant recipient with topical cidofovir.

Transpl Infect Dis 2018 Dec 28;20(6):e12989. Epub 2018 Sep 28.

Department of Pediatrics, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas.

We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following 7 months of topical cidofovir, without evidence of systemic toxicity or rejection. Read More

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http://doi.wiley.com/10.1111/tid.12989
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http://dx.doi.org/10.1111/tid.12989DOI Listing
December 2018
35 Reads

Multimodality Imaging Review of Anorectal and Perirectal Diseases With Histological, Endoscopic, and Operative Correlation, Part I: Anatomy and Neoplasms.

Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.

Department of Radiology, Louisiana State University Health Shreveport, Shreveport, LA.

A broad spectrum of pathology affects the rectum, anus, and perineum and understanding of its relevant anatomy is important in accurate reporting, particularly in rectal cancer. In this pictorial essay, correlative imaging, endoscopic, pathologic, and operative images are presented to illustrate normal anorectal anatomy and neoplastic conditions that affect the anus and rectum. A particular case-based focus is given to rectal adenocarcinoma with pelvic MR and surgical histopathology. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401326PMC
July 2018
27 Reads

[Clinicopathological features and management of penile verrucous carcinoma].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2. Read More

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November 2018
20 Reads

Treatment of intraurethral condylomata acuminata with surgery and cidofovir instillations in two immunocompromised patients and review of the literature.

Antiviral Res 2018 Oct 25;158:238-243. Epub 2018 Aug 25.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Condylomata acuminata (CA) or anogenital warts are benign proliferative lesions caused by low-risk human papillomaviruses (HPV). Treating CA can be very frustrating for patients and clinicians due to the high recurrence rates. Immunosuppression is associated with larger size of CA that are more frequently resistant to treatment. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.08.016DOI Listing
October 2018
27 Reads

Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission.

J Infect Dis 2019 Jan;219(2):275-283

Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston.

Background: Condylomata acuminata (anogenital warts [AGWs]) are prevalent in human immunodeficiency virus (HIV)-infected individuals and sexually active populations at risk for HIV acquisition and have been associated with HIV transmission. We compared AGW specimens to control tissue specimens for abundance, types, and location of HIV target cells and for susceptibility to HIV infection in vitro, to provide biologic evidence that AGWs facilitate HIV transmission.

Methods: We used immunohistologic staining to identify HIV target cells in AGW and control specimens. Read More

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http://dx.doi.org/10.1093/infdis/jiy505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306021PMC
January 2019
13 Reads

Human Papillomavirus-Associated Invasive Condylomas in a Man with Immunosuppressive Comorbidities.

Urol Int 2019 21;102(2):238-242. Epub 2018 Aug 21.

Department of Urology and Pediatric Urology, Saarland University, Homburg, Germany.

Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present the case of a 77-year-old Caucasian male with enormous genital warts of the penis, scrotum, groins and anus. Lesions were excised by electrosurgery. Read More

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http://dx.doi.org/10.1159/000491098DOI Listing
August 2018
26 Reads

Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.

Oncol Lett 2018 Sep 18;16(3):3241-3247. Epub 2018 Jun 18.

Department of Dermatology, Tianjin Union Medical Center, Tianjin 300121, P.R. China.

The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly increased caspase-3 and caspase-9 activities, induced B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein, tumor protein 53 and cyclin-dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV-18(+) cervical cancer cells. Read More

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http://dx.doi.org/10.3892/ol.2018.8983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096279PMC
September 2018
4 Reads

Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial.

Clin Exp Obstet Gynecol 2018 ;45(3):383-386

Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM.

Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Read More

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http://dx.doi.org/10.12891/ceog4112.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075835PMC
August 2018
14 Reads

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men.

PLoS One 2018 1;13(8):e0199033. Epub 2018 Aug 1.

Department of Surgery, University Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain.

Background: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men.

Aim: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice.

Methods: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199033PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070186PMC
January 2019
7 Reads

Successful treatment of penile condyloma acuminata accompanied with lichen planus with photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Dec 29;24:142-144. Epub 2018 Jul 29.

Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:

Condyloma acuminata and lichen planus are different cutaneous diseases with disparate etiologies. Simultaneous appearance of two diseases in the same area is rare. This report aims to share the clinical and pathological features of a rare case; introduce an effective and safe therapy of it so as to broaden the therapeutic spectrum of Photodynamic Therapy (PDT) indications. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2017.09.015DOI Listing
December 2018
4 Reads

Imiquimod-induced hypopigmentation following treatment of periungual verruca vulgaris.

Cutis 2018 Jun;101(6):466-468

Bay Pines VA Healthcare System, St. Petersburg, Florida, USA.

Imiquimod is a topical immunomodulating medication approved by the US Food and Drug Administration for the treatment of condyloma acuminata, actinic keratoses (AKs), and superficial basal cell carcinoma (BCC). Imiquimod commonly is used off label for its antiviral and antitumoral effects. We present a case of a 51-year-old man with vitiligolike depigmentation following treatment of periungual verruca vulgaris with imiquimod therapy. Read More

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June 2018
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Treatment of latent or subclinical Genital HPV Infection with 5-aminolevulinic acid-based photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Sep 23;23:362-364. Epub 2018 Jul 23.

Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Background: Genital HPV infections are widely prevalent. HPV can persist and be transmitted to partners even after warts are gone. The HPV genotype and viral load assay can reveal whether infections are persistent or latent, and it can serve as a predictor of infection clearance. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.07.014DOI Listing
September 2018
3 Reads

[A young man with extensive skin abnormalities].

Ned Tijdschr Geneeskd 2018 May 16;162. Epub 2018 May 16.

GGD Flevoland, Centrum Seksuele Gezondheid, Lelystad.

A 26-year-old man who has sex with men visited the STI clinic because of increasing skin abnormalities since four months. The patient had macular skin lesions on his penis and scrotum, condylomata lata in the anal region, cutaneous lesions on the feet, and a widespread papular rash. A secondary stage of syphilis was diagnosed. Read More

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May 2018
5 Reads

Development of a human papillomavirus type 6/11 vaccine candidate for the prevention of condyloma acuminatum.

Vaccine 2018 08 2;36(32 Pt B):4927-4934. Epub 2018 Jul 2.

Departments of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. Electronic address:

Condyloma acuminatum (CA) represents a significant human papillomavirus (HPV) disease burden worldwide, resulting in substantial healthcare costs and loss of life quality in both genders. To address this problem, we tried to develop a bivalent HPV6/11 virus-like particle (VLP) vaccine targeting CA. HPV6/11 VLPs were generated in Hansenula polymorpha, and a disassembly and reassembly (D/R) treatment was further conducted to improve the stability and monodispersity of the VLPs. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.06.041DOI Listing
August 2018
9 Reads

[Treatment of HPV-associated Anal Lesions in HIV-positive Patients - Comparison of Surgical Treatment and Topical Therapy with Imiquimod].

Zentralbl Chir 2018 Jul 3. Epub 2018 Jul 3.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Objectives: In HIV-patients, routine proctological assessment is warranted due to the high incidence of human papilloma virus (HPV) infection-related anogenital lesions, such as Condylomata acuminata (C. ac.), anal intraepithelial dysplasia (AIN) and anal cancer. Read More

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http://dx.doi.org/10.1055/a-0632-2017DOI Listing
July 2018
30 Reads

Anogenital warts in children: Analysis of a cohort of 34 prepubertal children.

Pediatr Dermatol 2018 Sep 1;35(5):e325-e327. Epub 2018 Jul 1.

Department of Dermatovenereology, Centro Hospitalar de São João, EPE, Porto, Portugal.

Anogenital warts are caused by infection with the human papillomavirus. We reviewed the clinical data of 34 children younger than 13 with anogenital warts referred to the department of dermatovenereology of a tertiary care hospital. Suspicion of sexual abuse was raised in 11 (32. Read More

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http://dx.doi.org/10.1111/pde.13543DOI Listing
September 2018
21 Reads

[Pigmented extramammary Paget's disease accompanied with condyloma acuminatum: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Jun;50(3):572-575

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis. Read More

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June 2018
12 Reads

A comparative study of two techniques in the treatment of condyloma acuminata.

Ann Ital Chir 2018 ;89:455-460

Objectives: Condyloma acuminata (CA) is mainly caused by human papillomavirus (HPV) types 6 and 11. Clinicians use many different methods to treat analcondyloma acuminate ( CA). In this study, we aimed to compare electrocautery ablation (ECA) and argon plasma coagulation (APC) techniques in terms of postoperative bleeding, pain, scar development, loss of sexual sensation, and recurrence rates. Read More

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January 2018
40 Reads