758,527 results match your criteria Computer aided surgery : official journal of the International Society for Computer Aided Surgery[Journal]


The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.

The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Read More

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December 2018

Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Advanced Design and Intelligent Computing, Dalian University, Ministry of Education, Dalian 116622, China.

Recently, due to the dual roles of DNA and enzyme, DNAzyme has been widely used in the field of DNA circuit, which has a wide range of applications in bio-engineered system, information processing and biocomputing. In fact, the activity of DNAzymes was regulated by subunits assembly, pH control and metal ions triggers. However, those regulations required to change the sequences of whole DNAzyme, as separating parts and inserting extra DNA sequence. Read More

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December 2018

Predicting Ames Mutagenicity Using Conformal Prediction in the Ames/QSAR International Challenge Project.

Mutagenesis 2018 Dec 12. Epub 2018 Dec 12.

Computer Learning Research Centre, Royal Holloway, University of London Egham, Surrey, UK.

Valid and predictive models for classifying Ames mutagenicity have been developed using conformal prediction. The models are Random Forest models using signature molecular descriptors. The investigation indicates, on excluding not-strongly mutagenic compounds (class B), that the validity for mutagenic compounds is increased for the predictions based on both public and the Division of Genetics and Mutagenesis, National Institute of Health Sciences of Japan (DGM/NIHS) data while less so when using only the latter data source. Read More

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December 2018

Sexual mixing in opposite-sex partnerships in Britain and its implications for STI risk: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Institute for Global Health, University College London, London, UK.

Background: The extent to which individuals are similar to their sexual partners influences STI-transmission probabilities, yet there is a dearth of empirical data, especially those representative of the population.

Methods: Analyses of data reported by 10 759 sexually active people aged 16-74 y interviewed for a British national probability survey undertaken in 2010-12. Computer-assisted self-interviews asked about partner numbers and characteristics of participants' three most recent partnerships (MRPs). Read More

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December 2018

Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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December 2018

Scattering characteristics of an exciton-plasmon nanohybrid made by coupling a monolayer graphene nanoflake to a carbon nanotube.

J Phys Condens Matter 2018 Dec 12. Epub 2018 Dec 12.

Advanced Computing and Simulation Laboratory, Monash University, Clayton,, Victoria 3800, Melbourne, Victoria, 3800, AUSTRALIA.

A hybrid nanostructure where a graphene nanoflake (GNF) is optically coupled to a carbon nanotube (CNT) could potentially possess enhanced sensing capabilities compared to the individual constituents whilst inheriting their high biocompatibility, favourable electrical, mechanical and spectroscopic properties. Therefore, in this paper, we investigate the scattering characteristics of an all-carbon exciton-plasmon nanohybrid which was made by coupling an elliptical GNF resonator to a semiconducting CNT gain element. We analytically model the nanohybrid as an open quantum system using cavity quantum electrodynamics. Read More

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December 2018

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

J Crit Care 2018 Dec 5;50:138-143. Epub 2018 Dec 5.

Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. Read More

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December 2018

A secure heterogeneous mobile authentication and key agreement scheme for e-healthcare cloud systems.

Authors:
Han-Yu Lin

PLoS One 2018 12;13(12):e0208397. Epub 2018 Dec 12.

Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung, Taiwan.

Heterogeneous mobile authentication is a crucial technique to securely retrieve the resource of e-healthcare cloud servers which are commonly implemented in a public key Infrastructure (PKI). Conventionally, a mobile data user can utilize a self-chosen password along with a portable device to request the access privilege of clouds. However, to validate the membership of users, a cloud server usually has to make use of a password table, which not only increases the burden of management, but also raises the possibility of information leakage. Read More

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December 2018

A new development of non-local image denoising using fixed-point iteration for non-convex ℓp sparse optimization.

PLoS One 2018 12;13(12):e0208503. Epub 2018 Dec 12.

Department of Mathematics, Southern Illinois University-Carbondale, Carbondale, IL, United States of America.

We proposed a new efficient image denoising scheme, which mainly leads to four important contributions whose approaches are different from existing ones. The first is to show the equivalence between the group-based sparse representation and the Schatten-p norm minimization problem, so that the sparsity of the coefficients for each group can be measured by estimating the underlying singular values. The second is that we construct the proximal operator for sparse optimization in ℓp space with p ∈ (0, 1] by using fixed-point iteration and obtained a new solution of Schatten-p norm minimization problem, which is more rigorous and accurate than current available results. Read More

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December 2018

PCSeg: Color model driven probabilistic multiphase level set based tool for plasma cell segmentation in multiple myeloma.

PLoS One 2018 12;13(12):e0207908. Epub 2018 Dec 12.

SBILab, Department of ECE, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), New Delhi, India.

Plasma cell segmentation is the first stage of a computer assisted automated diagnostic tool for multiple myeloma (MM). Owing to large variability in biological cell types, a method for one cell type cannot be applied directly on the other cell types. In this paper, we present PCSeg Tool for plasma cell segmentation from microscopic medical images. Read More

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December 2018

Susceptibility and resilience to cyber threat: Findings from a scenario decision program to measure secure and insecure computing behavior.

PLoS One 2018 12;13(12):e0207408. Epub 2018 Dec 12.

Department of Human Development and Family Studies, Iowa State University, Ames, Iowa, United States of America.

Interest in the individual differences underlying end user computer security behavior has led to the development of a multidisciplinary field of research known as behavioral information security. An important gap in knowledge and the motivation for this research is the development of ways to measure secure and insecure cyber behavior for research and eventually practice. Here we report a study designed to develop a technique for assessing secure and insecure cyber behavior for broad research use. Read More

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December 2018

A short certificateless aggregate signature against coalition attacks.

PLoS One 2018 12;13(12):e0205453. Epub 2018 Dec 12.

College of Computer Science and Engineering, Northwest Normal University, Lanzhou, Gansu, China.

Certificateless aggregate signature (CLAS) is a crucial cryptosystem. It can not only compress multiple signatures into a short signature, but also ensure the validity of each signature participating in the aggregation by verifying the validity of an resulting aggregate signature. Therefore, a secure and efficient CLAS scheme is very useful for resource-constrained environments because it greatly reduces the overall length of the signature and the verifier's computational overhead. Read More

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December 2018

Correction: Brain-Computer Interface-Based Communication in the Completely Locked-In State.

PLoS Biol 2018 Dec 12;16(12):e3000089. Epub 2018 Dec 12.

[This corrects the article DOI: 10.1371/journal.pbio. Read More

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December 2018

Measuring Work Related Physical and Mental Health Function: Updating the Work Disability Functional Assessment Battery (WD-FAB) using Item Response Theory.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Tufts University, Department of Occupational Therapy, Medford, MA (Marfeo); University of Pittsburgh, School of Health and Rehabilitation Sciences, Department of Physical Therapy (McDonough); Boston University School of Public Health, Department of Health Law Policy and Management, Boston, MA (Ni, Peterik, Kazis); National Institutes of Health Rehabilitation Medicine Department, Bethesda, MD (Porcino, Rasch, Chan); VHA Office of Reporting, Analytics, Performance, Improvement and Deployment (RAPID) (Meterko).

Objective: To further improve measurement of work-related physical and mental health by updating the Work Disability Assessment Battery (WD-FAB).

Methods: Cross-sectional study with 1024 disability claimants and 1000 working age (21-66 years) adults in the United States. Developed new items to replenish the WD-FAB and analyzed using factor analysis and item response theory (IRT). Read More

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December 2018

Design and Evaluation of a Wireless Electrocardiogram Monitor in an Operating Room: A Pilot Study.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anesthesia and Intensive Care, Military Teaching Hospital "Clermont Tonnerre", Brest, French.

Background: Wired electrocardiogram monitors are an important component of current perioperative monitoring. Wireless monitoring units could help reduce the number of cables attached to patients and thus improve anesthesia ergonomics and patient management. However, there is concern that electromagnetic interference generated by electrosurgical units may prevent effective wireless signals in the operating room. Read More

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December 2018

Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas.

Adv Skin Wound Care 2018 Dec 13. Epub 2018 Dec 13.

At the Poznań University of Medical Sciences in Poznań, Poland, Jacek Hermann, PhD, is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; Tomasz Banasiewicz is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; and Barbara Kołodziejczak, PhD, is Chair, Department of Computer Science and Statistics. The authors have disclosed no financial relationships related to this article. Submitted January 28, 2018; accepted in revised form May 25, 2018.

Background: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods.

Objective: To compare NCS with vacuum-assisted closure (VAC) treatment. Read More

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December 2018
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Leveraging Natural Language Processing: Toward Computer-Assisted Scoring of Patient Notes in the USMLE Step 2 Clinical Skills Exam.

Acad Med 2018 Dec 11. Epub 2018 Dec 11.

J. Salt is assistant vice president, Clinical Skills Evaluation Collaboration Assessments, National Board of Medical Examiners, Philadelphia, Pennsylvania. P. Harik is a senior measurement scientist, National Board of Medical Examiners, Philadelphia, Pennsylvania. M.A. Barone is vice president, Licensure Programs, National Board of Medical Examiners, Philadelphia, Pennsylvania.

The United States Medical Licensing Examination (USMLE) Step 2 Clinical Skills (CS) exam uses physician raters to evaluate patient notes written by examinees. In this Invited Commentary, the authors describe the ways in which the Step 2 CS exam could benefit from adopting a computer-assisted scoring approach that combines physician raters' judgments with computer-generated scores based on natural language processing (NLP). Since 2010, the National Board of Medical Examiners (NBME) has researched NLP technology to determine if it offers the opportunity to mitigate challenges associated with human raters while continuing to capitalize on the judgment of physician experts. Read More

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December 2018
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Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Larijani, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of).

Objective: The increasing prevalence of obesity over the past few decades constitutes a global health challenge. Pharmacological therapy is recommended to accompany life-style modification for obesity management. Here, we perform a clinical trial to investigate the effects of metformin on anthropometric indices and gut microbiota composition in non-diabetic, treatment-naive obese women with a low calorie diet (LCD). Read More

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December 2018

Automated homecage training of mice in a hold-still center-out reach task.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurobiology and Behavior, Cornell University, United States.

An obstacle to understanding neural mechanisms of movement is the complex, distributed nature of the mammalian motor system. Here we present a novel behavioral paradigm for high-throughput dissection of neural circuits underlying mouse forelimb control. Custom touch-sensing joysticks were used to quantify mouse forelimb trajectories with micron-millisecond spatiotemporal resolution. Read More

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December 2018
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Single molecule dynamics of the P granule scaffold MEG-3 in the C. elegans zygote.

Mol Biol Cell 2018 Dec 12:mbcE18060402. Epub 2018 Dec 12.

Department of Biological Sciences, Dartmouth College, Hanover NH 03755, USA.

During the asymmetric division of the C. elegans zygote, germ (P) granules are disassembled in the anterior cytoplasm and stabilized/assembled in the posterior cytoplasm, leading to their inheritance by the germline daughter cell. P granule segregation depends on MEG-3 and MEG-4, which are enriched in P granules and in the posterior cytoplasm surrounding P granules. Read More

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December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

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December 2018

Gaussian Process Surrogate Models for the CMA Evolution Strategy.

Evol Comput 2018 Dec 12:1-30. Epub 2018 Dec 12.

Institute of Computer Science, Czech Academy of Sciences, Pod Vodárenskou věží 2, 182 07 Prague, Czech Republic

This article deals with Gaussian process surrogate models for the Covariance Matrix Adaptation Evolutionary Strategy (CMA-ES)-several already existing and two by the authors recently proposed models are presented. The work discusses different variants of surrogate model exploitation and focuses on the benefits of employing the Gaussian process uncertainty prediction, especially during the selection of points for the evaluation with a surrogate model. The experimental part of the paper thoroughly compares and evaluates the five presented Gaussian process surrogate and six other state-of-the-art optimizers on the COCO benchmarks. Read More

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December 2018
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Virtual Reality for Teletherapy: Avatars May Combine the Benefits of Face-to-Face Communication with the Anonymity of Online Text-Based Communication.

Cyberpsychol Behav Soc Netw 2018 Dec 12. Epub 2018 Dec 12.

School of Psychology, University of Sydney , Sydney, Australia .

Self-disclosure is an essential component of social communication that has been associated with trust, liking, and ultimately strong relationships. As technology continues to develop, so do the number of methods to create and maintain relationships. While speaking face-to-face (FtF) remains the primary way to communicate, computer-mediated communication has become more common, meaning that research into self-disclosure has expanded to new domains, including virtual reality (VR). Read More

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December 2018

LigandScout Remote: A new User-Friendly Interface for HPC and Cloud Resources.

J Chem Inf Model 2018 Dec 12. Epub 2018 Dec 12.

High Performance Computing (HPC) clusters play a major role in scientific research. However, working with these clusters is often cumbersome, especially for researches without formal background in computer science. It requires preparation and transfer of the input data, manual gathering of results, and command-line expertise. Read More

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December 2018

[Close-to-win evaluations are affected by the outcome and delay between stopping the wheels in slot machines].

Psychiatr Hung 2018 ;33(4):340-346

Debreceni Egyetem, Pszichologiai Intezet, Szemelyiseg- es Klinikai Pszichologia Tanszek, Debrecen, Hungary, E-mail:

Introduction: Distinct structural characteristics of gambling may affect the development of gambling addiction differently. The current study is dealing with the frequency of near-miss outcomes which works like secondary reinforcement and thus may contribute to gambling addiction. Authors of this paper argue that different near miss configurations should specifically alter the experiences of the player and this phenomenon can be proved experimentally Methods: Participants played with a computer-simulated slot machine. Read More

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January 2018

Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818652. Epub 2018 Dec 12.

1 Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [O]HO positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO and CBF. Read More

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December 2018

Disparity in anomalous diffusion of proteins searching for their target DNA sites in a crowded medium is controlled by the size, shape and mobility of macromolecular crowders.

Soft Matter 2018 Dec 12. Epub 2018 Dec 12.

School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India.

Using extensive computer simulations, we analyzed the role of physical properties of molecular crowding agents such as size, shape and mobility in the target search dynamics of DNA binding proteins. Our main result is that the sub-diffusive dynamics of a protein inside a crowded medium strongly depends on the crowder properties and also on the protein's mode of diffusion. For instance, while scanning the DNA one-dimensionally, the protein dynamics does not vary with the change in crowder properties. Read More

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December 2018

Guided Reconstruction of Full-Length Isoforms from Short Reads by CIDANE.

Methods Mol Biol 2019 ;1870:199-208

Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.

Alternative splicing allows genes to express isoforms with different coding or regulatory functions on demand. While short read deep sequencing technologies (RNA-seq) provide an immediate measurement of local splicing events, the phasing of these events along full-length isoforms requires the computational inference of long-range dependencies from short-range data points. We introduce CIDANE, a tool for the assembly and quantification of full-length isoforms from short read RNA-seq data. Read More

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January 2019

Surgineering: a new type of collaboration among surgeons and engineers.

Int J Comput Assist Radiol Surg 2018 Dec 11. Epub 2018 Dec 11.

Chair of Micro Technology and Medical Device Technology, TUM Department of Mechanical Engineering, Technische Universität München, Boltzmannstraße 3, 85748, Garching bei München, Germany.

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December 2018
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SLIM microscopy allows for visualization of DNA-containing liposomes designed for sperm-mediated gene transfer in cattle.

Mol Biol Rep 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Sciences, University of Illinois, Urbana-Champaign, IL, 61801, USA.

Naked DNA has been shown to bind naturally to the sperm, a method called sperm-mediated gene transfer (SMGT). Based on these observations, we examined the efficiency of exogenous DNA binding to sperm using liposomes. In this experiment, we analyzed methods to select frozen-thawed bovine sperm, and evaluated the binding of exogenous DNA to those sperm. Read More

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December 2018

Deep-learning classification using convolutional neural network for evaluation of maxillary sinusitis on panoramic radiography.

Oral Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, 2-11 Suemori-dori, Chikusa-ku, Nagoya, 464-8651, Japan.

Objectives: To apply a deep-learning system for diagnosis of maxillary sinusitis on panoramic radiography, and to clarify its diagnostic performance.

Methods: Training data for 400 healthy and 400 inflamed maxillary sinuses were enhanced to 6000 samples in each category by data augmentation. Image patches were input into a deep-learning system, the learning process was repeated for 200 epochs, and a learning model was created. Read More

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December 2018

FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus.

Mol Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104, Freiburg, Germany.

Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between progenitor proliferation and neuronal differentiation. Read More

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December 2018

Development of an analytical prepCheck-supported approach to evaluate tutor-based assessments of dental students' practical skills.

Int J Comput Dent 2018 ;21(4):313-322

The aim of the present study was to develop an analytical computer-supported assessment concept for the objective evaluation of students' practical skills, and to investigate the assessor-dependent differences by setting tolerance limits applied during the 'glance and grade' evaluation. A sample of 54 conventionally supervised dental undergraduates were given training in the preparation of a macroretentive Class II cavity. The course participants then took a mandatory practical examination. Read More

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January 2018

Hinge axis determination of the temporomandibular joint and its interpretation: what do we really measure?

Authors:
Albert Mehl

Int J Comput Dent 2018 ;21(4):295-303

Terminal hinge axis (THA) determination is recommended in some clinical situations and for some diagnostic purposes. Different methods are described and are available for this task. In particular, circle fitting or iterative trace recording methods, in the conventional process known as the pantographic or Lauritzen method, have mostly been applied in clinical settings and have even been used as exact reference measures in many studies. Read More

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January 2018
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Quality improvement of functional diagnostics in dentistry through computer-aided diagnosis: a randomized controlled trial.

Int J Comput Dent 2018 ;21(4):281-294

Functional diagnostic examinations such as clinical functional analysis and manual structural analysis ('orthopedic tests') allow the dentist to establish a structured diagnosis. Previously, the process of correlating findings with the appropriate diagnoses was guided by human thought processes alone. The experimental diagnostic randomized controlled trial (RCT) in this study investigated whether computer-aided diagnosis (CADx) of temporomandibular disorders (TMD) offers quality advantages over traditional diagnosis (TRAD). Read More

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January 2018

A quantum machine learning algorithm based on generative models.

Sci Adv 2018 Dec 7;4(12):eaat9004. Epub 2018 Dec 7.

Center for Quantum Information, IIIS, Tsinghua University, Beijing 100084, PR China.

Quantum computing and artificial intelligence, combined together, may revolutionize future technologies. A significant school of thought regarding artificial intelligence is based on generative models. Here, we propose a general quantum algorithm for machine learning based on a quantum generative model. Read More

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December 2018

Dynamic thermal emission control with InAs-based plasmonic metasurfaces.

Sci Adv 2018 Dec 7;4(12):eaat3163. Epub 2018 Dec 7.

Geballe Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA.

Thermal emission from objects tends to be spectrally broadband, unpolarized, and temporally invariant. These common notions are now challenged with the emergence of new nanophotonic structures and concepts that afford on-demand, active manipulation of the thermal emission process. This opens a myriad of new applications in chemistry, health care, thermal management, imaging, sensing, and spectroscopy. Read More

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December 2018

Implications of protein conformations to modifying novel inhibitor Oseltamivir for 2009 H1N1 influenza A virus by simulation and docking studies.

Virusdisease 2018 Dec 1;29(4):461-467. Epub 2018 Sep 1.

Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, India.

Recently three FDA approved existing drugs, namely-Oseltamivir, Peramivir and Zanamivir, used against Neuraminidase (NA) for the inhibitory effect on the process of viral progeny release to inhibit infection. All NA subtypes has been divided into two groups (Group 1 and Group 2) based on phylogenetic study. Oseltamivir and Zanamivir drugs are designed for Group 2 NA but are also used against 2009 H1N1 NA that lies in Group 1. Read More

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December 2018

IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response.

J Immunol Res 2018 13;2018:1827901. Epub 2018 Nov 13.

Life Science School, Liaoning University, Shenyang 110036, China.

Background: Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis. Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis. So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice. Read More

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November 2018

Mandibular reconstruction with a ready-made type and a custom-made type titanium mesh after mandibular resection in patients with oral cancer.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):35. Epub 2018 Nov 25.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, 20, Geumo-ro, Mulgeum-eup, Yangsan, Gyeongsangnam-do South Korea.

Background: After the resection at the mandibular site involving oral cancer, free vascularized fibular graft, a type of vascularized autograft, is often used for the mandibular reconstruction. Titanium mesh (T-mesh) and particulate cancellous bone and marrow (PCBM), however, a type of non-vascularized autograft, can also be used for the reconstruction. With the T-mesh applied even in the chin and angle areas, an aesthetic contour with adequate strength and stable fixation can be achieved, and the pores of the mesh will allow the rapid revascularization of the bone graft site. Read More

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December 2018

Wireless Patrol Sign-In System with Mental Fatigue Detection.

J Healthc Eng 2018 12;2018:6419064. Epub 2018 Nov 12.

Department of Computer Science and Information Engineering, Chaoyang University of Technology, 168, Jifeng E. Rd., Wufeng District, Taichung 41349, Taiwan.

Current sign-in methods of patrolling security guards mainly comprise signature, image identification, and fingerprint identification; notably, none of these methods indicate the physical and mental conditions of such guards. In particular, when patrolling security guards perform their duties consecutively for a long period of time, adequate attention should be directed toward their levels of mental fatigue. When a handwriting sign-in system is adopted, security guards may not record their sign-in time accurately, or they may fake signatures during long shifts. Read More

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November 2018

Arrhythmia Classification of ECG Signals Using Hybrid Features.

Comput Math Methods Med 2018 12;2018:1380348. Epub 2018 Nov 12.

Department of Nuclear Engineering, King Abdulaziz University, Jeddah, Saudi Arabia.

Automatic detection and classification of life-threatening arrhythmia plays an important part in dealing with various cardiac conditions. In this paper, a novel method for classification of various types of arrhythmia using morphological and dynamic features is presented. Discrete wavelet transform (DWT) is applied on each heart beat to obtain the morphological features. Read More

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November 2018

Perception of Threatening Intention Modulates Brain Processes to Body Actions: Evidence From Event-Related Potentials.

Front Psychol 2018 27;9:2149. Epub 2018 Nov 27.

Department of Psychology, Shanghai Normal University, Shanghai, China.

Efficiently perceiving a threatening intention conveyed by others' bodily actions has great survival value. The current study examined if the human brain is sensitive to differences in intentions that are conveyed via bodily actions. For this purpose, a new intention categorization task was developed in which participants sat in front of a computer screen on which the pictures of highly threatening (HT), moderately threatening (MT), and non-threatening (NT) body actions were presented randomly. Read More

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November 2018

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications .

Front Pharmacol 2018 27;9:1350. Epub 2018 Nov 27.

Department of Biotechnology, Centre for High-Throughput Technologies, University of Rijeka, Rijeka, Croatia.

Unique and outstanding physical and chemical properties of zeolite materials make them extremely useful in a variety of applications including agronomy, ecology, manufacturing, and industrial processes. Recently, a more specific application of one naturally occurring zeolite material, clinoptilolite, has been widely studied in veterinary and human medicine. Due to a number of positive effects on health, including detoxification properties, the usage of clinoptilolite-based products has increased enormously. Read More

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November 2018

A Cadaveric Comparative Study on the Surgical Accuracy of Freehand, Computer Navigation, and Patient-Specific Instruments in Joint-Preserving Bone Tumor Resections.

Sarcoma 2018 13;2018:4065846. Epub 2018 Nov 13.

Department of Orthopedics, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands.

Orthopedic oncologic surgery requires preservation of a functioning limb at the essence of achieving safe margins. With most bone sarcomas arising from the metaphyseal region, in close proximity to joints, joint-salvage surgery can be challenging. Intraoperative guidance techniques like computer-assisted surgery (CAS) and patient-specific instrumentation (PSI) could assist in achieving higher surgical accuracy. Read More

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November 2018

Students' perception, attitudes, and readiness toward online learning in dental education in Saudi Arabia: a cohort study.

Adv Med Educ Pract 2018 22;9:855-863. Epub 2018 Nov 22.

Department of Advanced General Dentistry, The Dental Hospital, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Purpose: The purpose of this study was to assess students' perception, attitudes, and readiness toward online dental education in Saudi Arabia.

Materials And Methods: This is a longitudinal study using a 5-point Likert scale questionnaire distributed to a cohort group of undergraduate dental students at King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia, during their fourth year (T1) and internship year (T2). It assessed technological access, computer skills, online skills, and motivation level in using e-learning for personal and learning purposes; and overall readiness for e-learning adoption in dental education. Read More

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November 2018

Large-scale analysis reveals a novel risk score to predict overall survival in hepatocellular carcinoma.

Cancer Manag Res 2018 21;10:6079-6096. Epub 2018 Nov 21.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China,

Background: Hepatocellular carcinoma (HCC) is a major cause of cancer mortality and an increasing incidence worldwide; however, there are very few effective diagnostic approaches and prognostic biomarkers.

Materials And Methods: One hundred forty-nine pairs of HCC samples from Gene Expression Omnibus (GEO) were obtained to screen differentially expressed genes (DEGs) between HCC and normal samples. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Gene ontology enrichment analyses, and protein-protein interaction network were used. Read More

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November 2018

Impact of COPD on prognosis of lung cancer: from a perspective on disease heterogeneity.

Int J Chron Obstruct Pulmon Dis 2018 20;13:3767-3776. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China,

Background: COPD is an important comorbidity of lung cancer, but the impact of COPD on the outcomes of lung cancer remains uncertain. Because both COPD and lung cancer are heterogeneous diseases, we evaluated the link between COPD phenotypes and the prognosis of different histological subtypes of lung cancer.

Methods: In this retrospective study, subjects with a newly and pathologically confirmed diagnosis of lung cancer were enrolled from patients preparing for lung cancer surgery. Read More

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November 2018

Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.

Pediatr Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease and major pulmonary complication after premature birth. We have previously shown that increased intermittent hypoxemia (IH) events have been correlated to adverse outcomes and mortality in extremely premature infants. We hypothesize that early IH patterns are associated with the development of BPD. Read More

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December 2018

Improving palliative care with deep learning.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):122. Epub 2018 Dec 12.

Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Background: Access to palliative care is a key quality metric which most healthcare organizations strive to improve. The primary challenges to increasing palliative care access are a combination of physicians over-estimating patient prognoses, and a shortage of palliative staff in general. This, in combination with treatment inertia can result in a mismatch between patient wishes, and their actual care towards the end of life. Read More

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December 2018
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