312,591 results match your criteria Comprehensive Therapy [Journal]


Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions.

Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:

Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More

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November 2018

Ventilation/perfusion SPECT/CT in patients with severe and rigid scoliosis: An evaluation by relationship to spinal deformity and lung function.

Clin Neurol Neurosurg 2018 Dec 6;176:97-102. Epub 2018 Dec 6.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:

Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More

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December 2018

Molecular alterations in meningiomas: Literature review.

Clin Neurol Neurosurg 2018 Dec 7;176:89-96. Epub 2018 Dec 7.

Departament of Neurology, Laboratory of Molecular and Cellular Biology, LIM15, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.

Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Read More

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December 2018

Influence of the T to S mutation at the STMK motif on antibiotic resistance of penicillin binding protein 1A: A comprehensive computational study.

J Mol Graph Model 2018 Dec 7;87:185-191. Epub 2018 Dec 7.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The emergence of antibiotic resistance has attracted the attention of scientists and scientific circles over the decades. β-Lactam antibiotics resistance is a worldwide therapeutic challenge in bacterial infections, mediated through several mechanisms of which mutations in Penicillin Binding Proteins (PBPs) are an important issue, making critical therapeutic problems in the human population. Accordingly, investigating the dynamic structures of mutant variants could result in a profound understanding of such a specific resistance. Read More

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December 2018

Activation of peroxymonosulfate by magnetic catalysts derived from drinking water treatment residuals for the degradation of atrazine.

J Hazard Mater 2018 Dec 5;366:402-412. Epub 2018 Dec 5.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, China.

Magnetic catalysts (MCs) derived from iron-rich drinking water treatment residuals (WTRs) were prepared through pyrolysis treatment and introduced as activators of peroxymonosulfate (PMS) for refractory atrazine (ATZ) degradation. Comprehensive characterization analysis indicated that pyrolytic temperature could manipulate the crystalline structure evolution of the MCs and influence their physicochemical and catalytic properties. The catalytic performances of the as-prepared samples pyrolyzed at 600 °C (MC-600) and 1000 °C (MC-1000) were evaluated, and MC-1000 exhibited far more excellent catalytic reactivity than MC-600 in PMS oxidation system. Read More

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December 2018
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Synchronous occurrence of multiple distinct jaw lesions in Simpson-Golabi-Behmel Syndrome: A case report.

J Stomatol Oral Maxillofac Surg 2018 Dec 12. Epub 2018 Dec 12.

Associate Professor, Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.

Simpson-Golabi-Behmel Syndrome (SGBS) is an X-linked overgrowth syndrome characterized by pre- and postnatal overgrowth, typical facial appearance and multiple visceral, skeletal, and neurological anomalies. There is only few information in the current literature, on clinical and particularly dentofacial findings due to recent identification of the syndrome and its clinical overlap with other overgrowth syndromes. The aim of this case report is to present dentofacial findings in a 16-year-old boy who had been diagnosed with SGBS. Read More

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December 2018

Effective communication in the era of precision medicine: A pilot intervention with low health literacy patients to improve genetic counseling communication.

Eur J Med Genet 2018 Dec 12. Epub 2018 Dec 12.

Department of Social & Behavioral Sciences, University of California, San Francisco, United States.

Effective communication, where all parties share a common understanding, is necessary to realize the promise of Genomic Medicine. It is especially salient given the imperative to increase the participation of diverse populations in genomics research and to expand the reach of clinical genomics. We have previously shown that cancer genetic counseling is suboptimal for patients with limited health literacy. Read More

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December 2018
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A comprehensive analysis and optimization of continuous twin-screw granulation processes via sequential experimentation strategy.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables by employing sequential experimentation strategy. A low-dose formulation for granulation experiments contained anhydrous caffeine as the model drug. Read More

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December 2018

Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.

Genomics 2018 Dec 12. Epub 2018 Dec 12.

Genetics Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil. Electronic address:

Scarce data are available on the expression of Papillomavirus genome and the frequency of alternatively spliced E6/E7 mRNAs in invasive cervical cancer. We carried out a comprehensive characterization of HPV expression by RNA-Seq analysis in 22 invasive cervical cancer with HPV16 or HPV18, characterizing the presence of integrated/episomal viral DNA, the integration sites in human genome and the proportion of alternative splicing products of E6 and E7 genes. The expression patterns suggested the presence of episomal and/or integrated viral DNA, with integration detected in most tumors, frequently occurring within human genes in HPV18+ and in intergenic regions in HPV16+ tumors. Read More

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December 2018

Pathophysiological Mechanisms Implicated in Postpartum Depression.

Front Neuroendocrinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA. Electronic address:

This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. Read More

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December 2018

LeishInDB: a web-accessible resource for small molecule inhibitors against Leishmania sp.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007. India.

Despite the availability of drugs to treat Leishmaniasis, various other factors including drug resistance and adverse side effects encourage the researchers to search for new strategies and alternatives for treating Leishmaniasis. Repurposing and devising combination therapy with the existing small molecules would serve as an alternative strategy to address the issue, especially the drug resistance. Hence, here we report LeishInDB, a web-accessible resource of small molecule inhibitors having a varying degree of activity towards Leishmania sp. Read More

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December 2018

Diagnostic diversity - an indicator of institutional and regional healthcare quality.

Swiss Med Wkly 2018 Dec 15;148:w14691. Epub 2018 Dec 15.

Lung Centre, Cantonal Hospital St Gallen, Switzerland.

Aim: Our aim was to estimate the diagnostic performance of institutions and healthcare regions from a nationwide hospitalisation database.

Methods: The Shannon diversity index was used as an indicator of diagnostic performance based on the International Classification of Disease, 10th revision, German Modification (ICD-10-GM codes). The dataset included a total of 9,325,326 hospitalisation cases from 2009 to 2015 and was provided by the Swiss Federal Office for Statistics. Read More

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December 2018

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. Read More

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December 2018

Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.

Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.

Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Read More

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December 2018

Cancer survivorship: an integral part of Europe's research agenda.

Mol Oncol 2018 Dec 15. Epub 2018 Dec 15.

Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. Read More

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December 2018

Cross-country evidence on the social determinants of the post-socialist mortality crisis in Europe: a review and performance-based hierarchy of variables.

Sociol Health Illn 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, University of Massachusetts, USA.

An unprecedented mortality crisis befell the former socialist countries between 1989 and 1995, representing one of the greatest demographic shocks of the period after the Second World War. While it is likely that country-level variation in the post-socialist mortality crisis in Eastern Europe can be explained by a constellation of political and socio-economic factors, no comprehensive review of the existing scholarly attempts at explaining these factors exists. We review 39 cross-national multi-variable peer reviewed studies of social determinants of mortality in post-socialist Europe in order to assess the social factors behind the post-socialist mortality crisis, determine the gaps in the existing literature and to make suggestions for future research. Read More

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December 2018

Moonshot to Cancer Cure: Recruiting Policy to Break Down Silos.

Cancer Treat Res 2019 ;171:119-128

Robert H. Lurie Comprehensive Cancer Center, Survivorship Institute, Northwestern University, Chicago, IL, 60611, USA.

Funded by the 21 Century Cures Act, The Beau Biden Cancer Moonshot Initiative is broad, deep, integrative, and intended to expediently address cancer's most vexing problems. Launched in 2015, it is an effort to accelerate the pace of cancer research with a focus on breaking down silos through cross-pollination of research, recruitment of multidisciplinary clinical and basic science research teams, sharing of complex scientific databases, and the creation of public-private research partnerships. This audacious approach to cancer treatment is intended to alleviate the current burden of cancer within countries and across borders. Read More

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January 2019
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Cancer Drug Toxicity: Moving from Patient to Survivor.

Cancer Treat Res 2019 ;171:107-118

Cancer Survivorship Institute, Robert H. Lurie Comprehensive Cancer Center Northwestern University, Chicago, IL, USA.

Millions of individuals worldwide are living with cancer and have remained disease-free for more than 5 years. These individuals are considered to be cancer survivors. The advent of new targeted therapies and personalized treatment modalities have contributed to this increased survivorship. Read More

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January 2019

Anatomy of Risk Evaluation and Mitigation Strategies (REMS).

Cancer Treat Res 2019 ;171:93-105

Center for Pharmacoepidemiology and Pharmacoeconomic Research, College of Pharmacy, University of Illinois, Chicago, Illinois, USA.

This Chapter provides an introduction and overview of the U.S. FDA REMS program and applicable regulatory aspects. Read More

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January 2019

Biosimilars: Are They Really Safe?

Cancer Treat Res 2019 ;171:61-73

Robert H. Lurie Comprehensive Cancer Center Northwestern University, Chicago, IL, USA.

An increasing availability of biosimilars is an important step in the process of delivering optimal care while improving access for patients with cancer. Evolving regulatory mechanisms deal with biosimilars with different approaches within major regulatory agencies. We discuss some of the specific properties of biosimilars that merit attention in terms of optimizing their safety, delivering on appropriate related cost savings, and ensuring that appropriate premiums on innovative research are available to ensure ongoing progress in anticancer therapy. Read More

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January 2019
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Cancer Comorbidity: Implications for Drug Safety.

Cancer Treat Res 2019 ;171:21-35

Department of Medicine, Northwestern University, Chicago, IL, USA.

Cancer is primarily a disease of aging. This chapter discusses relevant aspect of the physiology of aging, medication use and toxicity, comorbidities, and specific challenges in treating older adults with cancer. Read More

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January 2019

Use of Decision Modelling in Economic Evaluations of Diagnostic Tests: An Appraisal and Review of Health Technology Assessments in the UK.

Pharmacoecon Open 2018 Dec 14. Epub 2018 Dec 14.

Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Worsley Building, Clarendon Way, Leeds, LS2 9LJ, UK.

Diagnostic tests play an important role in the clinical decision-making process by providing information that enables patients to be identified and stratified to the most appropriate treatment and management strategies. Decision analytic modelling facilitates the synthesis of evidence from multiple sources to evaluate the cost effectiveness of diagnostic tests. This study critically reviews the methods used to model the cost effectiveness of diagnostic tests in UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) reports. Read More

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December 2018

No overlap between IgG4-related disease and microscopic polyangiitis and granulomatosis with polyangiitis despite elevated serum IgG4 at diagnosis: a retrospective monocentric study.

Clin Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Objectives: We investigated whether elevated serum IgG4 at the time of diagnosis of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) may be associated with concurrent IgG4-related disease (IgG4-RD) in immunosuppressive drug-naïve patients.

Methods: We retrospectively reviewed the medical records of 46 MPA and GPA patients with results on serum IgG4 and histology at diagnosis. Elevated serum IgG4 was defined as IgG4 > 135 mg/dL. Read More

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December 2018

The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

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December 2018
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How many cadherins do human endothelial cells express?

Cell Mol Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, C/Nicolás Cabrera 1, Cantoblanco, 28049, Madrid, Spain.

The vasculature is the paradigm of a compartment generated by parallel cellular barriers that aims to transport oxygen, nutrients and immune cells in complex organisms. Vascular barrier dysfunction leads to fatal acute and chronic inflammatory diseases. The endothelial barrier lines the inner side of vessels and is the main regulator of vascular permeability. Read More

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December 2018

Adsorptive Removal of Tetracyclines and Fluoroquinolones Using Yak Dung Biochar.

Bull Environ Contam Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, 810008, Qinghai, China.

This study investigated the adsorptive removal of target fluoroquinolones and tetracyclines by biochar made by yak dung collected from the Qinghai-Tibet Plateau. Yak dung biochar pyrolyzed at 700 °C possessed surface area of 198.745 m g and multiple functional groups. Read More

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December 2018

Niacin, alkaloids and (poly)phenolic compounds in the most widespread Italian capsule-brewed coffees.

Sci Rep 2018 Dec 14;8(1):17874. Epub 2018 Dec 14.

Human Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy.

Coffee is one of the most popular beverages worldwide and, nowadays, one of the most practical way for its preparation is by prepacked capsules. The aim of this study was comparing the content in caffeine, trigonelline, N-methylpyridinium (NMP), niacin, and chlorogenic acids of 65 different capsule-brewed coffees, commercialised by 5 of the most representative brands in Italy. Coffees were prepared from capsules following manufacturer's instructions and analysed with an optimized UHPLC-MS/MS method able to assess all these phytochemicals in one single run. Read More

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December 2018

Identification of cytochrome P450 monooxygenase genes and their expression in response to high temperature in the alligatorweed flea beetle Agasicles hygrophila (Coleoptera: Chrysomelidae).

Sci Rep 2018 Dec 14;8(1):17847. Epub 2018 Dec 14.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Cytochrome P450 monooxygenases (P450s) are a large class of enzymes that play essential roles in metabolic processes such as hormone synthesis and the catabolism of toxins and other chemicals in insects. In the present study, we identified 82 P450 genes using comprehensive RNA sequencing in the flea beetle Agasicles hygrophila, and all of the sequences were validated by cloning and sequencing. Phylogenetic analysis showed that the P450 genes in A. Read More

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December 2018

Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Nat Commun 2018 Dec 14;9(1):5315. Epub 2018 Dec 14.

Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, Miami, FL, 33136, USA.

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Read More

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December 2018

Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.

Nat Commun 2018 Dec 14;9(1):5323. Epub 2018 Dec 14.

Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC, 20057, USA.

Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chemistry, metal coordination or supramolecular assemblies, quantitative analysis of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. Read More

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December 2018

Comprehensive Evaluation of User Interface for Ventilators Based on Respiratory Therapists' Performance, Workload, and User Experience.

Med Sci Monit 2018 Dec 15;24:9090-9101. Epub 2018 Dec 15.

Department of Medical Engineering, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND Poor ergonomic design of ventilators can result in human errors. In this study, we evaluated the ergonomics of ventilators through respiratory therapists' performance, workload, and user experience. MATERIAL AND METHODS Sixteen respiratory therapists were recruited to this usability study of 3 ventilators. Read More

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December 2018

Proteins, transcripts, and genetic architecture of seminal fluid and sperm in the mosquito .

Mol Cell Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Biology & Biochemistry, Syracuse University, United States of America

The yellow fever mosquito, , transmits several viruses causative of serious diseases, including dengue, Zika, and chikungunya. Some proposed efforts to control this vector involve manipulating reproduction to suppress wild populations or to replace them with disease-resistant mosquitoes. The design of such strategies requires an intimate knowledge of reproductive processes, yet our basic understanding of reproductive genetics in this vector remains largely incomplete. Read More

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December 2018
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Comprehensive scoping review of health research using social media data.

BMJ Open 2018 Dec 14;8(12):e022931. Epub 2018 Dec 14.

Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Introduction: The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews tend to be narrow in scope, with limited consideration of the different types of data, analytical methods and ethical issues involved. Read More

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December 2018

Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme.

BMJ Open 2018 Dec 14;8(12):e019572. Epub 2018 Dec 14.

Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand.

Introduction: Type 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people. Read More

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December 2018

Molecular Profiling of Pancreatic Cancer Patients-Response.

Clin Cancer Res 2018 Dec;24(24):6612

Perthera, Inc, McLean, Virginia.

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December 2018

Patient-Reported Outcomes with PD-1/PD-L1 Inhibitors for Advanced Cancer: A Meta-Analysis.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

General Medical Research Center, Faculty of Medicine, Fukuoka University, Japan.

Background: The aim of this meta-analysis was to compare patient-reported outcomes (PROs) between programmed death receptor-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors and standard-of-care therapy in patients with advanced cancer.

Methods: We searched randomized controlled trials (RCTs) comparing single-agent PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, atezolizumab, avelumab, or durvalumab) with standard-of-care therapy in patients with advanced cancer reporting PROs with generic measures: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (QLQ-C30) and the EuroQol Five Dimensions Questionnaire. The summary outcomes were changes in PROs from baseline to follow-up within and between treatment groups and time to deterioration (TTD) in PROs based on clinically meaningful change. Read More

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December 2018

Patient-Reported Toxicities During Chemotherapy Regimens in Current Clinical Practice for Early Breast Cancer.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: This study explores the incidence of patient-reported major toxicity-symptoms rated "moderate," "severe," or "very severe"-for chemotherapy regimens commonly used in early breast cancer.

Patients And Methods: Female patients aged 21 years or older completed a validated Patient-Reported Symptom Monitoring instrument and rated 17 symptoms throughout adjuvant or neoadjuvant chemotherapy. Fisher's exact tests compared differences in percentages in symptom ratings, and general linear regression was used to model the incidence of patient-reported major toxicity. Read More

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December 2018

Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM).

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, USA.

Background: First-line treatment for metastatic colorectal cancer (mCRC) typically entails a biologic such as bevacizumab (BEV) with 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) or 5-fluorouracil/leucovorin/irinotecan (FOLFIRI). STEAM (NCT01765582) assessed the efficacy of BEV plus FOLFOX/FOLFIRI (FOLFOXIRI), administered concurrently (cFOLFOXIRI-BEV) or sequentially (sFOLFOXIRI-BEV, FOLFOX-BEV alternating with FOLFIRI-BEV), versus FOLFOX-BEV for mCRC.

Patients And Methods: Patients with previously untreated mCRC ( = 280) were randomized 1:1:1 to cFOLFOXIRI-BEV, sFOLFOXIRI-BEV, or FOLFOX-BEV and treated with 4-6-month induction followed by maintenance. Read More

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December 2018

Development of an Electronic Data Collection System to Support a Large-Scale HIV Behavioral Intervention Trial: Protocol for an Electronic Data Collection System.

JMIR Res Protoc 2018 Dec 14;7(12):e10777. Epub 2018 Dec 14.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States.

Background: Advancing technology has increased functionality and permitted more complex study designs for behavioral interventions. Investigators need to keep pace with these technological advances for electronic data capture (EDC) systems to be appropriately executed and utilized at full capacity in research settings. Mobile technology allows EDC systems to collect near real-time data from study participants, deliver intervention directly to participants' mobile devices, monitor staff activity, and facilitate near real-time decision making during study implementation. Read More

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December 2018

Use of Mobile Devices to Help Cancer Patients Meet Their Information Needs in Non-Inpatient Settings: Systematic Review.

JMIR Mhealth Uhealth 2018 Dec 14;6(12):e10026. Epub 2018 Dec 14.

Division of Population Medicine, Cardiff University, Cardiff, United Kingdom.

Background: The shift from inpatient to outpatient cancer care means that patients are now required to manage their condition at home, away from regular supervision by clinicians. Subsequently, research has consistently reported that many patients with cancer have unmet information needs during their illness. Mobile devices, such as mobile phones and tablet computers, provide an opportunity to deliver information to patients remotely. Read More

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December 2018

Characterization of Right Ventricular Deformation in Pulmonary Arterial Hypertension Using Three-Dimensional Principal Strain Analysis.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: Pulmonary arterial hypertension (PAH) can cause maladaptive right ventricular (RV) functional changes associated with adverse prognosis that are challenging to accurately quantify noninvasively. The aim of this study was to explore principal strain (PS) with contraction angle analysis using three-dimensional echocardiography to characterize RV deformation changes in patients with PAH.

Methods: Three-dimensional echocardiography was performed in 37 patients with PAH and 20 healthy control subjects with two-component (primary and secondary) PS and principal contraction angle analysis. Read More

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December 2018

Focused Resident Education and Engagement in Quality Improvement Enhances Documentation, Shortens Hospital Length of Stay, and Creates a Culture of Continuous Improvement.

J Surg Educ 2018 Dec 12. Epub 2018 Dec 12.

Comprehensive Aortic Center, Cardiovascular Thoracic Institute, Keck Medical Center of University of Southern California, Los Angeles, California. Electronic address:

Purpose: System-based practice with an emphasis on quality improvement (QI) is a recent initiative for the American College of Surgeons and a core-competency for surgical trainees. Few surgical training programs have a curriculum for hospital-based QI.

Methods: Our vascular surgery service implemented several QI initiatives focused on decreasing length of stay (LOS) by targeting resident education and engagement. Read More

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December 2018

Navigating Uncertainty in the Management of Incidental Findings.

J Am Coll Radiol 2018 Dec 12. Epub 2018 Dec 12.

Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.

The lack of prospective outcomes studies for many types of incidental findings limits our understanding of both their natural history and the potential efficacy of treatment. To support decision making for the management of incidental findings, major sources of uncertainty in management pathways can be mapped and analyzed using mathematical models. This process yields important insights into how uncertainty influences the best treatment decision. Read More

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December 2018

The Hispanic Community Health Study/Study of Latinos Community and Surrounding Areas Study: sample, design, and procedures.

Ann Epidemiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, San Diego, CA.

Purpose: We describe the sample, design, and procedures for the Community and Surrounding Areas Study (CASAS), an ancillary to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The aim of SOL CASAS was to test an ecological model of macro- and micro-neighborhood environment factors, intermediate behavioral (physical activity) and psychosocial (e.g. Read More

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November 2018

Survival benefits associated with surgery for advanced non-small cell lung cancer.

J Thorac Cardiovasc Surg 2018 Nov 14. Epub 2018 Nov 14.

UC Davis Comprehensive Cancer Center, UC Davis Health, Sacramento, Calif.

Objective: Overall survival (OS) for advanced stage (IIIA-IV) non-small cell lung cancer (NSCLC) is highly variable, and retrospective data show a survival advantage for patients receiving therapeutic intent pulmonary resection. We hypothesized that this variability in OS can be modeled separately by stage to allow a personalized estimate of OS.

Methods: In a cohort of patients with advanced-stage NSCLC from the National Cancer Database, we assessed the accuracy of Surgical Selection Score (SSS) to predict OS using Cox proportional hazards models and determined by stage the effect of surgery on survival among people with similarly high levels of SSS. Read More

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November 2018

Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. Electronic address:

Bladder cancer remains a leading cause of cancer-related death because of its distant metastasis and high recurrence rates. Deregulation of circular RNAs (circRNAs) can act either as tumor suppressors or oncogenes to control cell proliferation, migration, and metastasis. The role of circMTO1 in bladder cancer remain unknown. Read More

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December 2018

Oral medicine: Today's future can become tomorrow's reality.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 22;126(5):409-414. Epub 2018 Aug 22.

Professor and Head, Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; Co-chair, Head & Neck Cancer/Oral Oncology Program, Neag Comprehensive Cancer Center, UConn Health Farmington, CT, USA.

There have been strategic clinical, educational, and research advances in the field of Oral Medicine over the past several decades. In many cases, Oral Medicine experts are contributing the lead role in these advances nationally and internationally. In addition, American Board of Dental Specialty recognition of Oral Medicine as a specialty in 2015 has positioned Oral Medicine professionals to substantively enhance the delivery of oral health care to medically complex patients as well. Read More

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November 2018

Omics approaches to study juvenile hormone synthesis.

Curr Opin Insect Sci 2018 Oct 26;29:49-55. Epub 2018 May 26.

Department of Biological Sciences and Biomolecular Science Institute, Florida International University, Miami, FL, USA. Electronic address:

The juvenile hormones (JHs) are a family of insect acyclic sesquiterpenoids produced by the corpora allata (CA), a pair of endocrine glands connected to the brain. They are involved in the regulation of development, reproduction, behavior, caste determination, diapause, stress response, and numerous polyphenisms. In the post-genomics era, comprehensive analyses using functional 'omics' technologies such as transcriptomics, proteomics and metabolomics have increased our understanding of the activity of the minute CA. Read More

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October 2018

Right ventricular failure following placement of a percutaneous left ventricular assist device.

Heart Lung 2018 Dec 11. Epub 2018 Dec 11.

Center for Comprehensive Cardiovascular care, St Louis University, 3635 Vista Avenue, FDT 13th Floor, Cardiology, St Louis, MO, United States.

Right ventricular (RV) dysfunction following surgical implantation of a left ventricular assist device (LVAD) is a well-documented phenomenon, and it is associated with poor outcomes. We are reporting a 25-year-old male patient who presented to the hospital with flu-like symptoms, hypotension and acute hypoxic respiratory failure. The patient's Laboratory data was significant for elevated troponin, and his Chest X-ray showed acute pulmonary edema. Read More

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December 2018