312,731 results match your criteria Comprehensive Ophthalmology Update[Journal]


A Farewell to Falsity: Shifting Standards in Medicare Fraud Enforcement.

Authors:
Isaac D Buck

Seton Hall Law Rev 2019 ;49(1):1-51

University of Tennessee College of Law.

For the better part of a decade, Americans have had a front-row seat to a fervent and turbulent debate over the future of their health care system. The passage of the Patient Protection and Affordable Care Act of 2010 (ACA), the most comprehensive health reform effort since the mid-1960s, ushered in a new era in health law and policy, granting millions of Americans access to health care. After multiple legal challenges and congressional efforts that ultimately failed to slay the law, the ACA had become entrenched by the end of the Obama administration, even though pieces of the law had failed to work exactly as planned. Read More

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January 2019

Prevalence of asthma in multiple sclerosis: A United States population-based study.

Mult Scler Relat Disord 2018 Dec 12;28:69-74. Epub 2018 Dec 12.

Neuroimmunological Disorders Gene-Environment Epidemiology Laboratory, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Background: Multiple sclerosis (MS) and asthma are complex multifactorial diseases which adversely impact daily functioning. However, the prevalence of asthma in those with MS is not clear. The objective of this study is to characterize the prevalence of asthma in those with MS, with considerations for age, gender, and race. Read More

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December 2018

Ambient PM air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study.

Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More

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December 2018

Assessment of forest fire impacts on carbonaceous aerosols using complementary molecular marker receptor models at two urban locations in California's San Joaquin Valley.

Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.

Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:

Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More

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December 2018

Extracellular polymeric substances of biofilms: Suffering from an identity crisis.

Water Res 2018 Nov 28;151:1-7. Epub 2018 Nov 28.

Department of Biotechcnology, Delft University of Technology, Delft, the Netherlands. Electronic address:

Microbial biofilms can be both cause and cure to a range of emerging societal problems including antimicrobial tolerance, water sanitation, water scarcity and pollution. The identities of extracellular polymeric substances (EPS) responsible for the establishment and function of biofilms are poorly understood. The lack of information on the chemical and physical identities of EPS limits the potential to rationally engineer biofilm processes, and impedes progress within the water and wastewater sector towards a circular economy and resource recovery. Read More

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November 2018

Systematic review and meta-analysis of basal cortisol levels in Borderline Personality Disorder compared to non-psychiatric controls.

Psychoneuroendocrinology 2018 Dec 10;102:149-157. Epub 2018 Dec 10.

Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Australia.

Objective: Borderline personality disorder (BPD) is a prevalent, complex, and serious mental disorder involving multiple symptoms and maladaptive behaviour. The underlying psychobiological mechanisms involved are not yet fully understood, but increasing evidence indicates that changes in hypothalamic-pituitary-adrenal stress axis (HPA) activity may contribute to BPD. Whilst various studies have demonstrated elevated levels of cortisol (the end-product of the HPA axis) in BPD sufferers, others have presented opposite findings. Read More

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December 2018

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-associated Genes in Patients With Multiple Colorectal Polyps.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Ambry Genetics, Aliso Viejo, CA.

Background And Aims: Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests-especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. Read More

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December 2018

Mechanism and kinetics studies of the atmospheric oxidation of p,p'-Dicofol by OH and NO radicals.

Chemosphere 2018 Dec 10;219:645-654. Epub 2018 Dec 10.

Environment Research Institute, Shandong University, Jinan, 250100, China.

As an effective organochlorine pesticide, Dicofol has been extensively applied in more than 30 countries for protecting over 60 different crops. Considering its large consumption and potential adverse effect on human health (endocrine disrupting and carcinogenicity), the fate of Dicofol sprayed into the air is of public concern. In this study, we conducted a comprehensive study on the reaction mechanisms of p,p'-Dicofol with OH and NO radicals using DFT method. Read More

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December 2018

EDTA-facilitated toxic tolerance, absorption and translocation and phytoremediation of lead by dwarf bamboos.

Ecotoxicol Environ Saf 2018 Dec 14;170:502-512. Epub 2018 Dec 14.

College of Landscape Architecture, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. Electronic address:

Bamboos are considered as potential plants for phytoremediation. However, the mechanisms of EDTA-assisted bamboo for lead (Pb) control has not been described. The objective of this study was to examine the tolerance and behaviors of Pb to screen bamboos for Pb-contaminated soil and to explore the effects of EDTA on their phytoremediation. Read More

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December 2018

Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations.

J Psychiatr Res 2018 Dec 8;109:185-192. Epub 2018 Dec 8.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; CEINGE-biotecnologie Avanzate, Naples, Italy. Electronic address:

Background: Attention-deficit/hyperactivity disorder (ADHD), a common psychiatric disorder, is identified by abnormal levels of impulsivity, inattention, and hyperactivity. MiRNAs play important roles in neural network development of the brain. Circulating miRNAs (cmiRNAs) are offered as promising noninvasive markers for psychiatric disorders. Read More

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December 2018

Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts.

Environ Res 2018 Dec 7;170:73-81. Epub 2018 Dec 7.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, member DZL, German Center for Lung Research, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: Depression has been associated with air pollution, as reported by animal and epidemiological studies. However, the relationship between ozone exposure and depression, especially among adolescents, is scarcely investigated.

Objectives: The study aimed to analyze associations between ozone exposure and depressive symptoms among German adolescents. Read More

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December 2018
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Insurance Approval for Proton Beam Therapy and its Impact on Delays in Treatment.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ. Electronic address:

Purpose: Prior authorization (PA) has been widely implemented for proton beam therapy (PBT). We sought to determine the association between PA determination and patient characteristics, practice guidelines, and potential treatment delays.

Methods And Materials: A single-institution retrospective analysis was performed of all patients considered for PBT between 2015 and 2018 at a National Cancer Institute-designated Comprehensive Cancer Center. Read More

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December 2018

Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Proteomics Research and Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School and Cancer Institute of New Jersey, Newark, NJ 07103, USA. Electronic address:

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for accurate identification of SS. Even though several mass spectrometry methods have emerged for this task, their practical use rests on the broad effectiveness of both sample preparation methods and bioinformatics tools. Read More

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December 2018

Dissecting the molecular effects of cigarette smoke on proteasome function.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. Electronic address:

Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke, one of the main risk factors for COPD, impairs proteasome function in vitro and in vivo. In the present study, we dissected the molecular changes induced by cigarette smoke on the proteasome in lung epithelial cells and mouse lungs. Read More

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December 2018

MALDI-TOF MS for rapid diagnosis of Anaerobiospirillum succiniciproducens, an unusual causative agent of bacteraemia in humans. Two case reports and literature review.

Anaerobe 2018 Dec 14. Epub 2018 Dec 14.

Clinical Microbiology Department, Hospital Universitario La Paz, Madrid, Spain.

Anaerobiospirillum succiniciproducens is a gram-negative anaerobic spiral rod which is part of the normal flora of dogs and cats and can produce bacteraemia and diarrhoea in humans. In this report we describe two cases of bacteraemia caused by A. succiniciproducens which was successfully identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Read More

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December 2018

Physician gender differences in processing surgical risk features in videos of standardized patients.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, University of Chicago.

Background: Physician gender differences exist for estimating surgical risk and recommending lung resection. We assessed gender differences in perceived importance of health characteristics portrayed by standardized patients posing as lung resection candidates.

Methods: Physicians read a clinical vignette categorized as low, average, or high surgical risk, then viewed a video of a standardized patient exhibiting vigorous, normal, or frail behavior. Read More

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December 2018

T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.

J Clin Oncol 2018 Dec 13:JCO2018782276. Epub 2018 Dec 13.

Patrick A. Ott, Dana-Farber Cancer Institute, Boston, MA; Yung-Jue Bang, Seoul National University College of Medicine, Seoul, The Republic of Korea; Sarina A. Piha-Paul, University of Texas MD Anderson Cancer Center, Houston, TX; Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Jaafar Bennouna, Centre Hospitalier Universitaire Nantes, Nantes; Jean-Charles Soria, University Paris-Sud and Gustave Roussy, Villejuif, France; Hope S. Rugo, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Roger B. Cohen, University of Pennsylvania, Philadelphia, PA; Bert H. O'Neil, Indiana University, Bloomington, IN; Janice M. Mehnert, Rutgers Cancer Institute of New Jersey, New Brunswick; Razvan Cristescu, Ping Yang, Kenneth Emancipator, Karen Stein, Mark Ayers, Andrew K. Joe, and Jared K. Lunceford, Merck & Co., Inc., Kenilworth, NJ; Juanita Lopez, Institute of Cancer Research, London, United Kingdom; Toshihiko Doi, National Cancer Center Hospital East, Chiba, Japan; and Emilie M.J. van Brummelen, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

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December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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December 2018

Evaluation of endogenous reference genes in Bactrocera cucurbitae by qPCR under different conditions.

PLoS One 2018 17;13(12):e0202829. Epub 2018 Dec 17.

Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.

Bactrocera cucurbitae (melon flies) are prominent invasive pests in southern China. To screen for a stable reference gene in melon flies suitable for comparing tissue samples subjected to different conditions in four categories (temperature, insect stage, days of age and gender), the expression of 12 candidate reference genes under different treatment conditions was analyzed by real-time fluorescent quantitative PCR. The results obtained from a comprehensive analysis with geNorm, NormFinder, BestKeeper and RefFinder software showed that the most stable reference gene was RPL60, and the least stable reference gene was actin-5. Read More

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December 2018

Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells.

PLoS One 2018 17;13(12):e0208756. Epub 2018 Dec 17.

Department of Biochemical, Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia, United States of America.

Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is differentially expressed in metabolism associated diseases, such as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS, we discovered that RARRES1 depletion in epithelial cells caused a global increase in lipid synthesis. Read More

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December 2018

Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

PLoS One 2018 17;13(12):e0208080. Epub 2018 Dec 17.

Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

EGFR-antibodies are associated with significant skin toxicity, including acneiform rash and folliculitis. It remains impossible to predict the occurrence of severe skin toxicity due to the lack of predictive markers. Here, we present the first genome-wide association study (GWAS) to find single nucleotide polymorphisms (SNPs) associated with EGFR inhibitor-induced skin toxicity using data of the multicentre randomized phase III CAIRO2 trial (clinicaltrials. Read More

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December 2018
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PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.

PLoS One 2018 17;13(12):e0208974. Epub 2018 Dec 17.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.

Background: Accurate classification of patients with inflammatory bowel disease into the subtypes ulcerative colitis (UC) and Crohn's disease (CD) is still a challenge, but important for therapy and prognosis.

Objectives: To evaluate the diagnostic utility of anti-neutrophil cytoplasmic antibodies specific for proteinase-3 (PR3-ANCA) for ulcerative colitis (UC) and the value of an antibody panel incorporating PR3-ANCA to differentiate between Crohn's disease (CD) and UC.

Study Design: In this cohort study, 122 pediatric and adolescent individuals were retrospectively included (61 IBD patients of two clinical centers, 61 non-IBD controls). Read More

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December 2018

regQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.

PLoS Genet 2018 Dec 17;14(12):e1007837. Epub 2018 Dec 17.

Biostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Read More

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December 2018

Opioid and Cannabis Co-Use among Adults with Chronic Pain: Relations to Substance Misuse, Mental Health, and Pain Experience.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Houston, Houston, TX (AHR, JB, DJP, MJV); Department of Psychology, Louisiana State University, Baton Rouge, LA (JDB); College of Nursing, Washington State University, Washington, DC (MFO); Department of Psychology, Syracuse University, New York, NY (JWD); Department of Behavioral Science, The University of Texas MD Anderson Cancer Center (MJZ); and HEALTH Institute, University of Houston, Houston, TX (MJZ).

Objectives: Opioid misuse constitutes a significant public health problem and is associated with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids remain the most widely prescribed class of medications. Prescription opioids are often used to treat chronic pain despite the risks associated with use, and chronic pain remains an important factor in understanding this epidemic. Read More

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December 2018

Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.

Int Clin Psychopharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychiatry, Psychosomatics and Psychotherapy.

Smoking is common among psychiatric patients and has been shown to accelerate the metabolism of different drugs. We aimed to determine the effect of smoking on the serum concentrations of psychopharmacological drugs in a naturalistic clinical setting. Dose-corrected, steady-state serum concentrations of individual patients were analyzed retrospectively by linear regression including age, sex, and smoking for amitriptyline (n=503), doxepin (n=198), mirtazapine (n=572), venlafaxine (n=534), clozapine (n=106), quetiapine (n=182), and risperidone (n=136). Read More

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December 2018

A Nursing Dashboard to Communicate the Evaluation of Program Outcomes.

Nurse Educ 2018 Dec 13. Epub 2018 Dec 13.

Author Affiliations: Assistant Professor (Dr Opsahl), Indiana University School of Nursing, Bloomington; and Professor (Dr Horton-Deutsch), University of San Francisco, California.

Background: Schools of nursing pursue accreditation to convey the quality of their program. Communication of their process for continuous quality improvement and ability to produce competent nurse graduates are common program goals.

Purpose: This article describes the implementation of a nursing dashboard as an innovative approach to examine and communicate program outcomes. Read More

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December 2018

Correlation Between Pathologic Complete Response in the Breast and Absence of Axillary Lymph Node Metastases After Neoadjuvant Systemic Therapy.

Ann Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands.

Objective: The aim was to investigate whether pathologic complete response (pCR) in the breast is correlated with absence of axillary lymph node metastases at final pathology (ypN0) in patients treated with neoadjuvant systemic therapy (NST) for different breast cancer subtypes.

Background: Pathologic complete response rates have improved on account of more effective systemic treatment regimens. Promising results in feasibility trials with percutaneous image-guided tissue sampling for the identification of breast pCR after NST raise the question whether breast surgery is a redundant procedure. Read More

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December 2018

A Comprehensive Analysis of the Association Between Gleason Score at a Positive Surgical Margin and the Risk of Biochemical Recurrence After Radical Prostatectomy.

Am J Surg Pathol 2018 Dec 14. Epub 2018 Dec 14.

Departments of Urology.

Our objective was to identify the best of the existing definitions of Gleason score (GS) at a positive surgical margin (PSM) by validating them in our radical prostatectomy cohort. We analyzed 251 patients who had mixed (3+4, 3+5, 4+3 or 5+3) pathologic GS and PSM. We used 5 definitions to record GS at a PSM. Read More

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December 2018

Disease-specific Hospitalizations Among 5-Year Survivors of Hepatoblastoma: A Nordic Population-based Cohort Study.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Aarhus University Hospital.

Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.

Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 2008 and 152,231 population comparisons were selected. Read More

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December 2018
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From A to D: A Unique Case Report of Recovery after Longitudinal Myelitis Related to Lupus.

Am J Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

HealthPartners Neuroscience Center, St. Paul, MN, USA.

Longitudinal myelitis secondary to an acute flare of systemic lupus erythematosus (SLE) has been reported in the literature. There have been few published cases of complete functional recovery in patients with systemic lupus erythematosus related longitudinal myelitis (SLE-LM). Of those cases, none have described in detail the rehabilitation course of treatment. Read More

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December 2018
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Binge Drinking's Effects on the Body.

Alcohol Res 2018 ;39(1):99-109

Patricia E. Molina, M.D., Ph.D., is the Richard Ashman, Ph.D., Professor; head of the Department of Physiology; and director of the Comprehensive Alcohol-HIV/AIDS Research Center and the Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Steve Nelson, M.D., is the John H. Seabury Professor of Medicine and the dean of the School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Studies have focused on the effects of chronic alcohol consumption and the mechanisms of tissue injury underlying alcoholic hepatitis and cirrhosis, with less focus on the pathophysiological consequences of binge alcohol consumption. Alcohol binge drinking prevalence continues to rise, particularly among individuals ages 18 to 24. However, it is also frequent in individuals ages 65 and older. Read More

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January 2018
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Engage In or Refrain From? A Qualitative Exploration of Premarital Sexual Relations Among Female College Students in Tehran.

J Sex Res 2018 Dec 17:1-14. Epub 2018 Dec 17.

c Department of Population Health , London School of Hygiene and Tropical Medicine.

This study explored the factors that educated young Iranian women consider when they decide whether to have premarital sex. Using a purposive sampling method, 30 in-depth interviews were conducted with female college students in both government and private universities in Tehran in 2005-2006. The respondents included unmarried women who had experienced sexual relations, unmarried women who had abstained, and married women. Read More

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December 2018

Diurnal variation of metabolites in three individual participants.

Chronobiol Int 2018 Dec 17:1-11. Epub 2018 Dec 17.

b Division of Cancer Epidemiology and Genetics , National Cancer Institute , Rockville , MD , USA.

The circadian system influences virtually all biological functions. Understanding the impact of circadian variation on metabolism may provide insight into mechanisms of circadian-associated disorders and guide the implementation of chrono-therapy. Previous research has reported circadian variation in 7-20% of metabolites in human blood. Read More

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December 2018

Using OmicsNet for Network Integration and 3D Visualization.

Curr Protoc Bioinformatics 2018 Dec 17:e69. Epub 2018 Dec 17.

Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada.

OmicsNet is a novel web-based tool for creating and visualizing complex biological networks in 3D space. By coupling a comprehensive knowledgebase with the powerful WebGL technology, OmicsNet allows researchers to intuitively explore molecular interactions and regulatory relationships among genes, transcription factors, microRNAs, and metabolites. OmicsNet fills an important gap by facilitating multi-omics integration and systems biology. Read More

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December 2018
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Expanded living-donor liver transplantation criteria for patients with hepatocellular carcinoma based on the Japanese nationwide survey: the 5-5-500 rule.

Transpl Int 2018 Dec 17. Epub 2018 Dec 17.

Research Institute of St. Mary's Hospital, Kurume, Japan.

Expansion of the liver transplantation indication criteria for patients with hepatocellular carcinoma (HCC) has long been debated. Here we propose new, expanded living-donor liver transplantation (LDLT) criteria for HCC patients based on a retrospective data analysis of the Japanese nationwide survey. A total of 965 HCC patients undergoing LDLT were included, 301 (31%) of whom were beyond the Milan criteria. Read More

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December 2018

Evaluation of management in North American zoos to enhance breeding success of the fishing cat (Prionailurus viverrinus) ex situ population.

Zoo Biol 2018 Dec 17. Epub 2018 Dec 17.

Department of Environmental Science and Policy, George Mason University, Fairfax, Virginia.

The ex situ population of fishing cats (Prionailurus viverrinus) face many challenges to its sustainability such as mate incompatibility, low founder numbers and disease prevalence. The North American population was monitored for a three-year period during institutional transfers and breeding introductions. In total, 26 fishing cats, including 15 different breeding pairs were monitored during 20 transfers. Read More

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December 2018

Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

Importance: Measurement of delirium severity has been recognized as highly important for tracking prognosis, monitoring response to treatment, and estimating burden of care for patients both during and after hospitalization. Rather than simply rating delirium as present or absent, the ability to quantify its severity would enable development and monitoring of more effective treatment approaches for the condition.

Objectives: To present a comprehensive review of delirium severity instruments, conduct a methodologic quality rating of the original validation study of the most commonly used instruments, and select a group of top-rated instruments. Read More

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December 2018

Tropolone natural products.

Nat Prod Rep 2018 Dec 17. Epub 2018 Dec 17.

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany.

Covering: 2008 to 2018This review provides a comprehensive overview of newly discovered natural products containing a tropolonoid motif covering 2008 up to 2018 and depicts the ecological context in which they have been isolated. This review has a strong focus on describing the different analytical tools and molecular biological approaches used to identify the underlying biosynthetic pathways. Read More

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December 2018

Ocular Involvement in Muckle-Wells Syndrome.

Ocul Immunol Inflamm 2018 Dec 17:1-9. Epub 2018 Dec 17.

a Pediatric Allergy and Clinical Immunology , Uludag University School of Medicine , Bursa , Turkey.

Purpose: To present the ocular findings of the members of a family that has the diagnosis of Muckle Wells syndrome, a form of cryopyrin associated periodic syndrome (CAPS).

Materials And Methods: Nine patients with MWS were included in this study. Each study participant underwent a systemic evaluation, comprehensive ophthalmic examination, and auxillary testings. Read More

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December 2018
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Three-way interaction model with switching mechanism as an effective strategy for tracing functionally-related genes.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Department of Basic Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran .

Introduction: Identification of functionally-related genes is an important step in understanding biological systems. The most popular strategy to infer functional dependence is to study pairwise correlations between gene expression levels. However, certain functionally-related genes may have a low expression correlationdue to their nonlinear interactions. Read More

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December 2018

Cancer biomarker discovery and translation: proteomics and beyond.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD 21287.

Introduction: Cancer is often diagnosed at late stages when the chance of cure is relatively low and although research initiatives in oncology discover many potential cancer biomarkers, few transition to clinical applications. This review addresses the current landscape of cancer biomarker discovery and translation with a focus on proteomics and beyond. Areas covered: The review examines proteomic and genomic techniques for cancer biomarker detection and outlines advantages and challenges of integrating multiple omics approaches to achieve optimal sensitivity and address tumor heterogeneity. Read More

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December 2018

An examination of Psychopathy Checklist-Revised latent factor structure via exploratory structural equation modeling.

Psychol Assess 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychology, University of Otago.

The Psychopathy Checklist-Revised (PCL-R; Hare, 1991, 2003) is widely used in clinical and forensic practice. Its latent factor structure has been subject to debate and controversy for almost 40 years. Various principal component and factor models have been proposed. Read More

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December 2018

Mental Disorders and Learning Disabilities in Children and Adolescents: Attention-Deficit/Hyperactivity Disorder.

Authors:
Barbara T Felt

FP Essent 2018 Dec;475:11-17

University of Michigan Medical School Department of Pediatrics - Developmental Behavioral Pediatrics, 1522 Simpson Road, East Ann Arbor, MI 48109-5718.

Attention-deficit/hyperactivity disorder (ADHD) is a neurobehavioral condition that affects more than 9% of US children and adolescents and often is seen in family medicine settings. A comprehensive evaluation for ADHD gathers information across time and settings; considers common comorbid or alternative conditions, such as learning disabilities and disorders of mood or anxiety, vision, hearing, and sleep; and includes a thorough physical examination. The need for additional evaluation is determined by the history and physical examination results. Read More

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December 2018

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Medicine, University of Freiburg, Germany.

A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of > 100 clinically-annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (p = 0. Read More

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December 2018

Safety culture in healthcare teams: A narrative review of the literature.

J Nurs Manag 2018 Dec 17. Epub 2018 Dec 17.

School of Nursing, Midwifery& Health Systems, Health Sciences Centre, University College Dublin, Dublin 4, Ireland.

Aim: Explores the recent literature to examine the factors that affect safety culture within healthcare teams.

Background: To deliver safe care to patients, healthcare organisations must understand and improve their safety culture. However, safety culture is a complex phenomenon which interacts with a myriad of factors, making it difficult to define, measure and improve. Read More

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December 2018

Mobilising Mothers: The 1917 National Baby Week.

Authors:
Linda Bryder

Med Hist 2019 Jan;63(1):2-23

This article focuses on Britain's 1917 National Baby Week and specifically how it played out in London. Pageantry and celebration were an important part of the event, and possibly a welcome distraction from the trials and horrors of war, and they were embraced by women of all social classes. But there was much more to it, as women who led the event seized the opportunity for political purposes, in what appeared to be an unthreatening environment of celebrating motherhood. Read More

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January 2019

Evaluating the palatability of fermented foods.

Biosci Biotechnol Biochem 2018 Dec 16:1-5. Epub 2018 Dec 16.

b Department of Life Environment , Koshien Junior College , Nishinomiya , Japan.

The present review deal with the novel studies which present possibility of generating a novel sensory evaluation instrument for describing comprehensive food palatability. These studies suggest the palatability can be dissected into its componential subdomains and the subdomains in turn reconstitute comprehensive palatability with evaluation of the quantitative contribution of each subdomain. The studies suggest the novel instrument is useful for comprehensive evaluation of palatability of multifarious fermented foods. Read More

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December 2018

Strength Measurement After Achilles Tendon Repair.

Foot Ankle Spec 2018 Dec 17:1938640018819779. Epub 2018 Dec 17.

Department of Orthopedic Surgery, New York Presbyterian/Columbia University Medical Center, New York, NY.

The goal of treatment after Achilles tendon rupture (ATR) is to restore appropriate tension to the tendon, so that normal baseline strength and functional soft-tissue length can be achieved. The assessment of plantarflexion strength has shown widespread variability. The purpose of this study is to document variations in strength assessment after the treatment of ATR in the literature. Read More

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December 2018

Could problem lists summarize comprehensive geriatric assessments? A nationwide cross-sectional survey on geriatricians' attitudes towards problem lists.

Geriatr Gerontol Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Aim: The use of problem lists is encouraged to overcome the inconsistency in reporting comprehensive geriatric assessment results. The present study aimed to identify the latent variables influencing the use of geriatrician problem lists.

Methods: Surveys were sent to all geriatricians registered with the Japan Geriatrics Society (n = 1439) as of November 2015, and responses (n = 204) were analyzed with univariate and exploratory factor analyses. Read More

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December 2018

Visualization of inhomogeneous current distribution on ZrO-coated LiCoO thin-film electrodes using scanning electrochemical cell microscopy.

Chem Commun (Camb) 2018 Dec 17. Epub 2018 Dec 17.

Graduate School of Environmental Studies, Tohoku University, 6-6-11-604, Aramaki Aoba, Aoba-ku, Sendai 980-8579, Japan and WPI-Advanced Institute for Materials Research (AIMR), Tohoku University, 2-1-1-509, Katahira, Aoba-ku, Sendai 980-8577, Japan.

Cathode surface coating with metal-oxide thin layers has been intensively studied to improve the cycle durability of lithium-ion batteries. A comprehensive understanding of the metal-oxide morphology and the local electrochemical properties is essential for figuring out the metal-oxide coating effect. In this study, scanning electrochemical cell microscopy (SECCM) is used to analyze the surface morphology with high spatial resolution, together with the local electrochemical properties. Read More

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December 2018