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Otolaryngol Clin North Am 2022 Jun 21. Epub 2022 Jun 21.

Department of Head and Neck Surgery, Kaiser Permanente Medical Center at Walnut Creek, 1425 South Main Street, 3rd Floor, Walnut Creek, CA 94596, USA. Electronic address:

Chondrolaryngoplasty is a well-described surgical procedure most commonly performed as part of facial feminization surgery for transgender patients with a diagnosis of gender dysphoria. A complete understanding of relevant neck anatomy and laryngeal function is critical to optimizing surgical outcomes. The overall goal of the procedure is to maximally reduce the thyroid cartilage prominence while preserving laryngeal integrity and minimizing the risk of external scarring. Read More

Front Biosci (Landmark Ed) 2022 Jun;27(6):175

Department of Thyroid and Vascular Surgery, the Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China.

Background: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous. In the current study, we aimed to explore the function of miR-4463 in hypoxia-induced endothelial cells and determine its molecular mechanisms.

Methods: CCK-8 assay and flow cytometry were performed to evaluate cell viability and apoptosis. Read More

Medicina (Kaunas) 2022 Jun 1;58(6). Epub 2022 Jun 1.

Third Department of General Surgery, Medical School, AHEPA University Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.

: Recurrent laryngeal nerve injury is one of the major complications of thyroidectomy, with the lateral thyroid ligament (Berry's ligament) being the most frequent site of nerve injury. Neuromonitoring during thyroidectomy revealed three possible anatomical regions of the recurrent laryngeal nerve P1, P2, and P3. P1 represents the recurrent laryngeal nerve's caudal extralaryngeal part and is primarily associated with Berry's ligament. Read More

Cancers (Basel) 2022 Jun 9;14(12). Epub 2022 Jun 9.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8641, Japan.

The prolonged survival of metastatic cancer patients highlights the importance of the local control of spinal metastases, which reduce patient performance status. This retrospective study examined the medium to long-term outcomes of spinal metastasectomy by evaluating 124 patients who underwent metastasectomy for isolated spinal metastases (2006-2018) with a postoperative follow-up for a minimum of 3 years. The findings present information on patient demographics (i. Read More

Harefuah 2022 Jun;161(6):355-360

Department of Otolaryngology - Head and Neck Surgery, Assuta Medical Center, Ben Gurion University in Beer Sheva, Tel Aviv, Israel.

Introduction: The use of transoral endoscopic vestibular approach for thyroidectomy (TOETVA) and parathyroid (TOEPVA) has been increasing worldwide, including in Israel.

Aims: To describe a single institute experience of the first 100 patients undergoing TOETVA or TOEPVA.

Methods: A prospective study of all patients undergoing TOETVA or TOEPVA. Read More

J Pain Res 2022 16;15:1719-1728. Epub 2022 Jun 16.

Minimally Invasive Spine Surgery, Chengde Medical University Affiliated Hospital, Chengde, Hebei Province, People's Republic of China.

Purpose: This study aimed to investigate the use of the percutaneous intervertebral foramen lens technology for secondary molding of the intervertebral foramen in the treatment of calcified lumbar discs.

Methods: The study included 104 patients who were divided into two groups. Group A comprised 50 patients with calcified lumbar disc herniation and group B comprised 54 patients with non-calcified lumbar disc herniation diagnosed by computed tomography and magnetic resonance imaging. Read More

Laryngoscope Investig Otolaryngol 2022 Jun 19;7(3):901-905. Epub 2022 May 19.

Department of Otolaryngology - Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA.

Objective: To describe common intraoperative and pathologic findings of atypical parathyroid tumors (APTs) and evaluate clinical outcomes in patients undergoing parathyroidectomy.

Methods: In this multi-institutional retrospective case series, data were collected from patients who underwent parathyroidectomy from 2000 to 2018 from three tertiary care institutions. APTs were defined according to the AJCC eighth edition guidelines and retrospective chart review was performed to evaluate the incidence of recurrent laryngeal nerve injury, recurrence of disease, and disease-specific mortality. Read More

Surg Endosc 2022 Jun 22. Epub 2022 Jun 22.

Department of Minimally Invasive Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, 510120, People's Republic of China.

Background: Recent years there have been witnessed considerable advances in endoscopic selective lateral neck dissection (LND). However, dissection of lymph nodes at level IV and level VI via the chest approach is inherently challenging. In this study, we used combined trans-oral and chest approach for endoscopic thyroidectomy in patients with cT1-2N1bM0 papillary thyroid carcinoma (PTC). Read More

N Z Med J 2022 Jun 10;135(1556):127-131. Epub 2022 Jun 10.

Department of Otolaryngology-Head and Neck Surgery, Waikato Hospital, New Zealand.

Papillary thyroid cancer is the most common type of well-differentiated thyroid cancer. It is associated with a survival rate greater than 95% with appropriate treatment, particularly in younger patients. We present the unique case of a 25-year-old male with severe Autistic spectrum disorder (ASD) with a right level V neck mass of several months. Read More

Front Surg 2022 27;9:905920. Epub 2022 May 27.

Second Department of General Surgery, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Haici Hospital), Qingdao, China.

Objective: Analyze the clinical effect of modified small incision thyroidectomy and evaluate the influencing factors of hypocalcemia (EH) in patients after operation.

Methods: A total of 220 patients with thyroid cancer in our hospital from October 2019 to October 2021 were selected. The patients were randomly divided into a control group and an observation group, with 110 patients in each group. Read More

Int J Hyperthermia 2022 ;39(1):813-821

Department of Abdominal Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: To evaluate the safety and efficacy of microwave ablation (MWA) versus repeat surgery for treating metastatic lymph nodes (MLNs) in papillary thyroid carcinoma (PTC).

Methods: Between July 2017 and October 2020, 67 patients were enrolled in this retrospective study. 19 and 48 patients underwent MWA and repeat surgery, respectively. Read More

J Pak Med Assoc 2022 May;72(5):843-849

Department of Surgery, Bahawal Victoria Hospital, Bahawalpur, Pakistan.

Objective: To study multinodular goitre patients' surgery by direct observation of surgical technique, and to compare complications with surgeons' skills and experience, for improved training of future thyroid surgeons.

Methods: Based on positivist epistemology and analytical observational design, this prospective double-blind study of a cohort of multinodular goitre patients operated upon by variedly experienced surgeons, was conducted at Bahawal Victoria Hospital Bahawalpur and Nishtar Medical University Hospital Multan, Pakistan, from December 2016 to April 2019. Patients were admitted through outpatient department and operated upon in routine operation lists. Read More

Front Endocrinol (Lausanne) 2022 20;13:868606. Epub 2022 May 20.

Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Purpose: Central lymph node metastasis (CLNM) is regarded as a predictor for local recurrence in patients with papillary thyroid carcinoma (PTC) but the role of prophylactic central lymph node dissection (CLND) is controversial. Our study aims to identify the clinical factors associated with CLNM and develop a nomogram for making individualized clinical decisions.

Method: The perioperative data of 1,054 consecutive patients between Jan 2019 and April 2021, in our center, were reviewed and analyzed. Read More

J Otolaryngol Head Neck Surg 2022 Jun 11;51(1):26. Epub 2022 Jun 11.

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.

Background: For unilateral papillary thyroid carcinoma (PTC) patients with contralateral benign nodules, optimal treatment decisions are made according to patient preference and the disease's pathological features. This study was performed to evaluate the efficacy and complications of hemithyroidectomy with intraoperative radiofrequency ablation (RFA) compared with total thyroidectomy.

Methods: Patients with unilateral PTC and cytologically benign contralateral nodules were enrolled from 2014 to 2018. Read More

Langenbecks Arch Surg 2022 Jun 11. Epub 2022 Jun 11.

Department of Surgery, International Goodwill Hospital, 1-28-1 Nishigaoka, Izumi-ku, Yokohama, Kanagawa, 245-0006, Japan.

Purpose: After our group described the first remote-access thyroidectomy series in 2000, the procedure has been further developed. Although a thoracoscopic approach with a conventional open cervical incision for thyroid goiters with mediastinal extension has been performed at many institutions, remote-access thyroidectomy for cervicomediastinal goiters has not been established. We have performed combined thoracoscopic and axillary subcutaneous endoscopic thyroidectomies (axillo-thoracic endoscopic thyroidectomies). Read More

Front Endocrinol (Lausanne) 2022 24;13:850235. Epub 2022 May 24.

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Thyroidectomy for massive goiters is challenging because of the increased risk of tracheomalacia, combined sternotomy, postoperative morbidity, and mortality, whereas studies investigating the clinicopathologic characteristics, postoperative morbidities, and surgical outcomes of massive goiters are limited.

Methods: Patients with goiters undergoing thyroid surgery between 2009 and 2019 were retrospectively reviewed. A total of 227 patients were enrolled and divided into massive goiter group and large goiter group according to the weight of the goiter. Read More

J Clin Med 2022 May 29;11(11). Epub 2022 May 29.

Department of Surgical Sciences, University of Cagliari, Policlinico Duilio Casula, 09042 Monserrato, CA, Italy.

Background: In thyroid surgery, achieving accurate haemostasis is fundamental in order to avoid the occurrence of complications. Energy-based devices are currently extensively utilized in this field of surgery. This study aims to compare Harmonic Focus and Thunderbeat Open Fine Jaw with regard to surgical outcomes and complications. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Jun;30(3):937-942

Department of Hematology, Wuhan No.1 Hospital, Wuhan 430022, Hubei Province, China,E-mail:

Objective: To investigate the safety and efficacy of a new proteasome inhibitor Ixazomib followed by autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of POEMS syndrome.

Methods: The clinical manifestations, diagnosis and treatment process and follow-up results of 4 patients with POEMS syndrome who were treated with Ixazomib-based regimen combined with AHSCT in Wuhan No.1 Hospital from February 2018 to July 2020 were analyzed retrospectively. Read More

JAMA Oncol 2022 Jun 9. Epub 2022 Jun 9.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Definitive diagnosis of a thyroid nodule in a child is obtained through diagnostic surgery. This is problematic because pediatric thyroid surgery is associated with higher rates of complications. In adults, preoperative molecular testing improves the management of thyroid nodules, but this has not been validated in children. Read More

Radiologia (Engl Ed) 2022 May-Jun;64(3):195-205

Servicio de Cirugía, Agencia Sanitaria Costa del Sol, Marbella, Málaga, Spain.

Objectives: To determine the diagnostic performance of ultrasound-guided core-needle biopsy in thyroid nodules after two inconclusive fine-needle aspiration biopsies. To assess the complications of core-needle biopsy. To analyze the reliability of diagnoses obtained with core-needle biopsy. Read More

Methods Mol Biol 2022 ;2534:57-78

Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Cervical lymph node metastasis is frequent in patients with papillary thyroid carcinoma. In addition to the extent of thyroidectomy, the need as well as the extent of concomitant lymphadenectomy has been a subject of controversy and debate. The central compartment is the most frequent site of metastasis followed by the lateral compartment although skip metastasis in the lateral compartment can occur. Read More

Methods Mol Biol 2022 ;2534:39-56

Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Papillary thyroid carcinoma is the most common endocrine malignancy and accounts for the overwhelming majority of thyroid carcinoma. This recent dramatic increase in incidence is almost exclusively attributed to the incidental detection of small papillary thyroid carcinoma or microcarcinoma. Surgical management of thyroid carcinoma has been evolving to avoid overtreating patients by adopting the appropriate risk-based approach including the recommendation of hemithyroidectomy for low-risk carcinoma, the avoidance of routine prophylactic central nodal dissections, a higher threshold in using postoperative radioiodine ablation after total thyroidectomy, and the active observation or surveillance of papillary microcarcinoma as a viable alternative option instead of immediate surgical treatment. Read More

Methods Mol Biol 2022 ;2534:29-37

Cancer Molecular Pathology of School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

Fine-needle aspiration biopsy is the most common method for preoperative diagnosis of thyroid carcinomas including papillary carcinoma. The procedure is best performed with ultrasound by operator with professional skill and knowledge. Several guidelines recommend the indication of fine-needle aspiration concerning the pattern of ultrasound and size of nodules. Read More

Orbit 2022 Jun 7:1-4. Epub 2022 Jun 7.

Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of Sao Paulo, Sao Paulo, Brazil.

Two patients with thyroid eye disease underwent inferomedial orbital decompression complicated by a cerebrospinal fluid (CSF) leak. One of the cases developed a postoperative pneumocephalus resolved with conservative measures. In the second case, the CSF leak was managed intraoperatively. Read More

Am J Surg 2022 May 27. Epub 2022 May 27.

Albany Medical Center, Department of Surgery, 50 New Scotland Avenue, Albany, NY, 12208, USA. Electronic address:

Background: Functional dependency has been associated with increased risk of adverse events following many surgical procedures. We hypothesized that dependent patients would have an increased risk of complications following thyroidectomy.

Methods: We performed a retrospective review of total thyroidectomies performed from 1/2012-12/2019 as identified by CPT codes using the National Surgical Quality Improvement Project (NSQIP) database. Read More

BMJ Case Rep 2022 06 6;15(6). Epub 2022 Jun 6.

Department of Otolaryngology - Head and Neck Surgery, Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan.

World J Clin Cases 2022 May;10(13):4153-4160

Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, South Korea.

Background: Primary hyperparathyroidism (PHPT) is the most common cause of pregnancy-related hypercalcemia. PHPT can cause maternal and fetal complications in pregnant women. General anesthesia for non-obstetric surgery in pregnant women is associated with maternal hazards and concerns regarding long-term neonatal neurocognitive effects. Read More

Front Surg 2022 19;9:905413. Epub 2022 May 19.

The Nanhua Affiliated Hospital, Department of Hemodialysis Room, Hengyang Medical School, University of South China, Hengyang, China.

Objective: To observe the effects of high-quality whole-course care on the psychological status and postoperative pharyngeal complications in patients undergoing surgery for secondary hyperparathyroidism (SHPT) to chronic rrenal failure (CRF).

Methods: The clinical data of 62 patients who underwent surgical treatment for CRF-SHPT from April 2018 to October 2021 in our department were retrospectively analyzed. According to the different nursing methods after admission, they were divided into two groups, of which 33 patients who received high-quality whole-course care were the high-quality group, and 29 patients who received routine nursing were the regular group. Read More

Radiother Oncol 2022 May 31;173:197-206. Epub 2022 May 31.

Mount Vernon Cancer Centre, Northwood, UK; Division of Cancer Sciences, University of Manchester, UK. Electronic address:

After liver and lungs, bone is the third most common metastatic site (Nystrom et al., 1977). Almost all malignancies can metastasize to the skeleton but 80% of bone metastases originate from breast, prostate, lung, kidney and thyroid cancer (Mundy, 2002). Read More

J Minim Access Surg 2022 Jun 2. Epub 2022 Jun 2.

Department of General Surgery, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Background: Over the last two decades, several endoscopic thyroidectomy methods have been developed. However, there are some limitations in these procedures. To date, the optimal surgical approach for thyroid cancer has not yet been developed. Read More