71,924 results match your criteria Complications of Myocardial Infarction


Coronary endarterectomy: an old tool for patients currently operated on with coronary artery bypass grafting. Long-term results, risk factor analysis.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):219-226. Epub 2018 Dec 31.

Department of Cardiac Surgery, Tor Vergata University Policlinic, Rome, Italy.

Aim: Coronary endarterectomy (CE) may provide a useful adjunctive technique to coronary artery bypass grafting (CABG) in patients with diffuse coronary artery disease. Nevertheless, the incidence of complications still remains high, long-term results remain unclear, and no risk factors for late mortality have been completely described yet.

Material And Methods: We retrospectively reviewed 90 consecutive patients (67 ±8. Read More

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http://dx.doi.org/10.5114/kitp.2018.80917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329878PMC
December 2018

Factors Associated With Return to Work After Acute Myocardial Infarction in China.

JAMA Netw Open 2018 Nov 2;1(7):e184831. Epub 2018 Nov 2.

Department of Cardiology, Peking University People's Hospital, Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Beijing, People's Republic of China.

Importance: Return to work is an important indicator of recovery after acute myocardial infarction. Little is known, however, about the rate of returning to work within the year after an acute myocardial infarction in China, as well as the factors associated with returning to work after an acute myocardial infarction.

Objectives: To determine the rate of return to work within 12 months after acute myocardial infarction, classify the reasons why patients did not return to work, and identify patient factors associated with returning to work. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.4831DOI Listing
November 2018
1 Read

Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction.

JAMA Netw Open 2018 Aug 3;1(4):e181079. Epub 2018 Aug 3.

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Importance: Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission.

Objectives: To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1079DOI Listing
August 2018
3 Reads

Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study.

J Hypertens 2019 Feb;37(2):365-371

Department of Internal Medicine, Maastricht University Medical Centre.

Introduction: Type 2 diabetes (T2D) is associated with cardiovascular disease complications such as myocardial infarction and stroke. These complications are at least partially the consequence of diabetes-associated increased arterial stiffness. Metformin, a first choice oral glucose-lowering drug, has been associated with potential cardio-protective effects. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001892DOI Listing
February 2019

[Influenza infection: An update for clinicians].

Rev Med Interne 2019 Jan 10. Epub 2019 Jan 10.

Département de maladies infectieuses et tropicales, CHU François-Mitterrand, 21000 Dijon, France.

Lower respiratory infections remain the deadliest communicable disease in the world. Influenza infections are particularly involved, whether intrinsically, or more frequently, by promoting bacterial infections and superinfections. The flu is also responsible for the decompensation of many comorbidities and could lead to some myocardial infarction and stroke. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.12.010DOI Listing
January 2019

Acute, in-hospital outcome of percutaneous coronary intervention for in-stent chronic total occlusion.

Cardiovasc Revasc Med 2018 Dec 19. Epub 2018 Dec 19.

Department of Cardiology, Helios Clinic Velbert, Velbert, Germany.

Background: Percutaneous coronary intervention (PCI) of total chronic total occlusion (CTO) still remains a major challenge in interventional cardiology. Recanalization of in-stent CTO (IS-CTO) is associated with inferior success rates. This present study aims to comparatively evaluate the acute outcome of patients with IS-CTO and de novo CTO. Read More

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http://dx.doi.org/10.1016/j.carrev.2018.12.007DOI Listing
December 2018

Cancer Therapeutics-Related Cardiovascular Complications. Mechanisms, Diagnosis and Treatment.

Curr Pharm Des 2019 Jan 10. Epub 2019 Jan 10.

1st Department of Cardiology, 'Hippokration' Hospital, University of Athens Medical School, Athens. Greece.

Background: Chemotherapy regimens have improved prognosis and mortality of patients with malignant diseases. The development of therapies however has widened the cardiotoxic spectrum and the cardiac related effects of antineoplastic drugs.

Methods: A review of the literature under the search terms Anthracyclines; oncology; cardiotoxicity, cardio-oncology; chemotherapy; heart failure was used for the identification of the most relevant articles. Read More

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http://dx.doi.org/10.2174/1381612825666190111101459DOI Listing
January 2019

Radial Artery Versus Right Internal Thoracic Artery Versus Saphenous Vein as the Second Conduit for Coronary Artery Bypass Surgery: A Network Meta-Analysis of Clinical Outcomes.

J Am Heart Assoc 2019 Jan;8(2):e010839

3 Schulich Heart Centre Sunnybrook Health Science University of Toronto Canada.

Background There remains uncertainty regarding the second-best conduit after the internal thoracic artery in coronary artery bypass grafting. Few studies directly compared the clinical results of the radial artery ( RA ), right internal thoracic artery ( RITA ), and saphenous vein ( SV ). No network meta-analysis has compared these 3 strategies. Read More

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http://dx.doi.org/10.1161/JAHA.118.010839DOI Listing
January 2019

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis.

Semin Thromb Hemost 2019 Jan 11. Epub 2019 Jan 11.

Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. Read More

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http://dx.doi.org/10.1055/s-0038-1677040DOI Listing
January 2019

Nonobstructive coronary artery myocardial infarction complicated by heart failure, ventricular aneurysm, and incessant ventricular arrhythmia: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e13995

First Hospital of Jilin University, Changchun.

Rationale: Myocardial infarction with nonobstructive coronary artery (MINOCA) is one of the common causes of cardiac related death. While patients with MINOCA usually do not need coronary artery intervention treatments, the prognosis could be worsened if the condition is not appropriately managed. This report describes a case of MINOCA patient suffered with multiple complications. Read More

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http://dx.doi.org/10.1097/MD.0000000000013995DOI Listing
January 2019

Procedural Outcomes Of Primary Percutaneous Coronary Intervention In Elderly Patients With Stemi.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):585-588

Department of Cardiology, Ayub Teaching Hospital Abbottabad, Pakistan.

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide, and coronary artery disease (CAD) is the most prevalent manifestation associated with high mortality and morbidity. Older age is independent predictor of cardiovascular mortality and death. Elderly may experience high rates of complications following acute STEMI. Read More

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January 2019
2 Reads

Multivessel Disease As A Prognostic Marker In Patients Presenting For Primary Percutaneous Coronary Intervention.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):534-538

Cardiology Department, National Institute of Cardiovascular Diseases, Karachi, Pakistan.

Background: Multi-vessel disease is associated with higher mortality rates in ST-Elevation Myocardial Infarction (STEMI) patients, which may further alter clinical course and decision making. Hence, the purpose of this study is to determine prevalence, in hospital and early after discharge (up to 30 days) outcome of patients with multi-vessel disease as compared to single vessel disease presenting with acute STEMI undergoing Primary PCI.

Methods: This study includes 282 consecutive selected patients, presented in emergency department with acute STEMI; undergo primary percutaneous coronary intervention (PCI) at Catheterization Laboratory of National Institute of Cardiovascular Diseases (NICVD), Karachi Pakistan during the study period of 17th December 2016 to 16th June 2017. Read More

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January 2019
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Platelet Inhibition with Cangrelor and Crushed Ticagrelor in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of the CANTIC Study.

Circulation 2019 Jan 11. Epub 2019 Jan 11.

Cardiology, University of Florida College of Medicine - Jacksonville, FL.

Background: The platelet inhibitory effects induced by oral P2Y receptor antagonists are delayed in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (P-PCI). In turn, this leads to a gap in platelet inhibition exposing patients to an increased risk of early thrombotic complications underscoring the need to define strategies associated with more effective platelet inhibition in the peri-PCI period. Cangrelor is an intravenous P2Y inhibitor with prompt and potent antiplatelet effects. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038317DOI Listing
January 2019

Sticky Platelet Syndrome: 35 Years of Growing Evidence.

Semin Thromb Hemost 2019 Jan 10. Epub 2019 Jan 10.

Department of Haematology and Transfusion Medicine, National Centre of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

Since the identification of antithrombin deficiency by Egeberg in 1956, ongoing research in prothrombotic defects continues to progress. Interestingly, past research has predominantly focused on coagulation factors and not on other components of the hemostatic system. The possible role of platelet function defects in the development of thrombotic events was suggested for the first time in the late 1970s, when an increased platelet adhesiveness and aggregation after epinephrine (EPI) and adenosine diphosphate (ADP) was found in a group of patients with unexplained transient ischemic attack. Read More

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http://dx.doi.org/10.1055/s-0038-1676581DOI Listing
January 2019

ST-Elevation Myocardial Infarction in Patients With Malignancies.

Kardiologiia 2018 Dec 25;58(12):5-12. Epub 2018 Dec 25.

Samara State Medical University.

Acute myocardial infarction (MI), the most severe complication of coronary artery disease, develops in 2-4% of patients with various malignancies.

Purpose: to explore the specific properties of ST-segment elevation myocardial infarction (STEMI) course in patients with cancer and its effect on short-term outcome.

Materials And Methods: We included in this study 45 patients with STEMI and history of cancer hospitalized in the period from 01. Read More

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http://dx.doi.org/10.18087/cardio.2018.12.10204DOI Listing
December 2018

Acute Infection and Myocardial Infarction.

N Engl J Med 2019 01;380(2):171-176

From the Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston (D.M.M.); National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (M.S.A.); and the Ottawa Hospital Research Institute and University of Ottawa, Ottawa (V.F.C.-M.).

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http://www.nejm.org/doi/10.1056/NEJMra1808137
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http://dx.doi.org/10.1056/NEJMra1808137DOI Listing
January 2019
7 Reads

Correlation between organ-specific co-morbidities and complications in bladder cancer patients undergoing radical cystectomy.

Scand J Urol 2019 Jan 9:1-6. Epub 2019 Jan 9.

a Department of Urology , Aarhus University Hospital , Aarhus , Denmark.

Objective: To evaluate the association between patients' organ-specific co-morbidities and post-operative complications following radical cystectomy for bladder cancer.

Patients And Methods: All patients who underwent radical cystectomy at Aarhus University Hospital during the period from January 2006 to February 2014 were included retrospectively. A total of 40 comorbidities and 59 complications were registered meticulously. Read More

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http://dx.doi.org/10.1080/21681805.2018.1531921DOI Listing
January 2019

Clinical Relevance of Troponin T Profile Following Cardiac Surgery.

Front Cardiovasc Med 2018 13;5:182. Epub 2018 Dec 13.

Department of Cardiovascular Surgery, Bern University Hospital and University of Bern, Bern, Switzerland.

Peak post-operative cardiac troponin T (cTnT) independently predicts mid- and long-term outcome of cardiac surgery patients. A few studies however have reported two peaks of cTnT over the first 48-72 h following myocardial reperfusion. The aim of the current study was to better understand underlying reasons of these different cTnT profiles and their possible relevance in terms of clinical outcome. Read More

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https://www.frontiersin.org/article/10.3389/fcvm.2018.00182/
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http://dx.doi.org/10.3389/fcvm.2018.00182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301188PMC
December 2018
1 Read

Intravitreal bevacizumab treatment for neovascular age-related macular degeneration and thromboembolic events.

Eur J Ophthalmol 2019 Jan 8:1120672118823128. Epub 2019 Jan 8.

6 Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.

Background:: Systemic complications of intravitreal anti-vascular endothelial growth factor agents are relatively uncommon but highly significant.

Objectives:: Primary objective: To assess the risk for thromboembolic events following intravitreal bevacizumab injection in neovascular age-related macular degeneration patients by a large population-based study. Secondary objective: To analyze the association between injection frequency and the risk for thromboembolic events, the time interval between the injection and the thromboembolic events, and the influence of chronic diseases on complications rate. Read More

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http://dx.doi.org/10.1177/1120672118823128DOI Listing
January 2019

Incidence and outcome of peri-procedural cardiogenic shock: results from the international Euro Heart Survey PCI registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 8:2048872618822460. Epub 2019 Jan 8.

1 Department of Cardiology, Justus-Liebig University of Giessen, Germany.

Background:: There is a large body of literature on acute myocardial infarction complicated by cardiogenic shock. However, very little is known about patients who are initially haemodynamically stable and develop cardiogenic shock during percutaneous coronary intervention.

Methods:: A total of 47,407 consecutive patients were prospectively enrolled in the PCI Registry of the Euro Heart Survey Programme. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618822460
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http://dx.doi.org/10.1177/2048872618822460DOI Listing
January 2019
1 Read

Long-Term Outcomes of Carotid Endarterectomy and Carotid Artery Stenting When Performed by a Single Vascular Surgeon.

Vasc Endovascular Surg 2019 Jan 6:1538574418823379. Epub 2019 Jan 6.

1 The Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, MD, USA.

Objectives:: Carotid artery endarterectomy (CEA) and carotid artery stenting (CAS) are 2 effective treatment options for carotid revascularization and stroke prevention. The long-term outcomes of Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) reported similar stroke and death rate between the 2 procedures. This study presents the short- and long-term outcomes of CEA and CAS of all risk patients performed by a single vascular surgeon in a real-world setting. Read More

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http://journals.sagepub.com/doi/10.1177/1538574418823379
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http://dx.doi.org/10.1177/1538574418823379DOI Listing
January 2019
3 Reads
0.766 Impact Factor

Carotid Artery Stenting: Current State of Evidence and Future Directions.

Acta Neurol Scand 2019 Jan 4. Epub 2019 Jan 4.

Interventional Radiology Service - Department of Radiology, Austin Hospital, Melbourne, Australia.

Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for carotid artery stenosis. Several randomised controlled trials (RCTs) have compared CEA to CAS in the treatment of carotid artery stenosis. These studies have suggested that CAS is more strongly associated with periprocedural stroke, however CEA is more strongly associated with myocardial infarction. Read More

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http://doi.wiley.com/10.1111/ane.13062
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http://dx.doi.org/10.1111/ane.13062DOI Listing
January 2019
2 Reads
2.395 Impact Factor

Early and Long-Term Outcomes in Patients Undergoing Cardiac Surgery Following Iatrogenic Injuries During Percutaneous Coronary Intervention.

J Am Heart Assoc 2019 Jan;8(1):e010940

1 University department of Cardiac Surgery Leipzig Heart Center Germany.

Background Iatrogenic coronary artery injuries during percutaneous coronary interventions ( PCI ) often require emergent surgical management. Our study evaluated the early and long-term outcomes in patients undergoing surgical treatment of iatrogenic PCI complications and identified the predictors of operative and long-term mortality. Methods and Results Pre-, intra- and post-operative data and hospital outcomes of 168 consecutive patients undergoing cardiac surgical procedures for iatrogenic complications following PCI between December 1999 and July 2015, were prospectively collected in our computerized database. Read More

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http://dx.doi.org/10.1161/JAHA.118.010940DOI Listing
January 2019

Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis.

Fertil Steril 2019 Jan;111(1):168-177

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China; The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Jinan, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China.

Objective: To explore metabolic disturbances in nonobese women with polycystic ovary syndrome (PCOS) compared with nonobese healthy controls.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183207
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http://dx.doi.org/10.1016/j.fertnstert.2018.09.013DOI Listing
January 2019
4 Reads

Transoral Versus Transnasal Approach for Craniovertebral Junction Pathologies: Which Route Is Better?

Acta Neurochir Suppl 2019 ;125:181-186

Institute of Neurosurgery, Catholic University of Rome, Rome, Italy.

Background: Several pathologies that affect the craniovertebral junction (CVJ) can be treated by means of a microsurgical transoral approach (TOA) or, alternatively, with an endoscopic endonasal approach (EEA), which is potentially able to overcome some complications associated with the former approach. In this paper, after discussing updates in the recent literature, to which we add our own surgical experience, we critically analyse these procedures with the aim of demonstrating that the TOA still deserves to be considered a viable alternative and that, in selected cases, it can even be considered superior to the EEA.

Methods: Our experience involves 25 anterior procedures in 24 paediatric and adult patients (18 TOA and seven EEA). Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_27DOI Listing
January 2019
1 Read

Outcomes of Multimodality In situ Recanalization in Hybrid Operating Room (MIRHOR) for symptomatic chronic internal carotid artery occlusions.

J Neurointerv Surg 2019 Jan 4. Epub 2019 Jan 4.

Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University, Beijing, China.

Background: An in situ recanalization procedure of endovascular therapy (ET) or carotid endarterectomy (CEA) has been attempted in patients with symptomatic chronic internal carotid artery occlusions (ICAOs), though the recanalization rates of both are low.

Objective: To investigate the outcomes of Multimodality In situ Recanalization for ICAOs in a Hybrid Operating Room (MIRHOR) at the same session.

Methods: Symptomatic chronic ICAOs were classified into type A or B (short occlusion with or without a tapered residual root [TRR]), and C or D (long occlusion with or without TRR), and managed in a hybrid operating room with ET, CEA, or both, as needed. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014384DOI Listing
January 2019
1 Read

Incidence, Mortality, and Outcome-Predictors of Sudden Cardiac Arrest Complicating Myocardial Infarction Prior to Hospital Admission.

Circ Cardiovasc Interv 2019 Jan;12(1):e007081

SAMU 78, Versailles Hospital, Le Chesnay, France (Y.L.).

Background: Mortality of ST-segment-elevation myocardial infarction (STEMI) decreased drastically, mainly through reduction in inhospital mortality. Prehospital sudden cardiac arrest (SCA) became one of the most feared complications. We assessed the incidence, outcome, and prognosis' predictors of prehospital SCA occurring after emergency medical services (EMS) arrival. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007081DOI Listing
January 2019
4 Reads
6.218 Impact Factor

Unstable angina: trends and characteristics associated with length of hospitalization in the face of diminishing frequency-an evidence of a paradigm shift.

Ann Transl Med 2018 Dec;6(23):454

Department of Medicine, Division of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA.

Background: Unstable angina (UA) has been one of the most common presentations of acute coronary syndrome. The numbers of admitted UA patients have been diminishing in the recent past. However, we are seeing higher costs and higher length of inpatient stay. Read More

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http://dx.doi.org/10.21037/atm.2018.11.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312815PMC
December 2018
1 Read

Relation of hemoglobin level to no-reflow in patients with ST-segment elevation myocardial infarction undergoing primary coronary intervention.

Postepy Kardiol Interwencyjnej 2018 11;14(4):383-390. Epub 2018 Dec 11.

Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: The primary goal in the management of acute ST segment elevation myocardial infarction (STEMI) is to open the occluded artery at an early stage. The development of no-reflow is multifactorial, and the etiology is not fully understood. There is accumulating evidence that anemia is related to a series of severe complications in cardiovascular disease (CVD) such as thromboembolic events, bleeding complications, uncontrolled hypertension, and inflammation characterized by elevated levels of inflammatory cytokines. Read More

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http://dx.doi.org/10.5114/aic.2018.79868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309849PMC
December 2018

Proton pump inhibitors: Review of reported risks and controversies.

Laryngoscope Investig Otolaryngol 2018 Dec 19;3(6):457-462. Epub 2018 Oct 19.

Department of Otolaryngology-Head and Neck Surgery University of Cincinnati College of Medicine and Neurosensory Disorders Center at UC Gardner Neuroscience Institute Cincinnati Ohio U.S.A.

Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age. These may be beneficial to treat many gastrointestinal conditions, such as gastroesophageal reflux or Barrett's esophagus as well as laryngopharyngeal reflux. However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia. Read More

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http://dx.doi.org/10.1002/lio2.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302736PMC
December 2018

Comparison of major adverse event rates after elective endovascular aneurysm repair in New England using a novel measure of complication severity.

J Vasc Surg 2018 Dec 28. Epub 2018 Dec 28.

Maine Medical Center, Portland, Me.

Objective: Major adverse event (MAE) rates are used as an outcome measure after surgical procedures. Although MAE rates summarize the occurrences of adverse events, they do not reflect differences in severity of these events. We propose that a measure of complication severity could provide a more accurate assessment about the quality of care. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.055DOI Listing
December 2018
1 Read

Does pregnancy complication history improve cardiovascular disease risk prediction? Findings from the HUNT study in Norway.

Eur Heart J 2018 Dec 27. Epub 2018 Dec 27.

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Postboks 8905, Trondheim, Norway.

Aim: To evaluate whether history of pregnancy complications [pre-eclampsia, gestational hypertension, preterm delivery, or small for gestational age (SGA)] improves risk prediction for cardiovascular disease (CVD).

Methods And Results: This population-based, prospective cohort study linked data from the HUNT Study, Medical Birth Registry of Norway, validated hospital records, and Norwegian Cause of Death Registry. Using an established CVD risk prediction model (NORRISK 2), we predicted 10-year risk of CVD (non-fatal myocardial infarction, fatal coronary heart disease, and non-fatal or fatal stroke) based on established risk factors (age, systolic blood pressure, total and HDL-cholesterol, smoking, anti-hypertensives, and family history of myocardial infarction). Read More

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http://dx.doi.org/10.1093/eurheartj/ehy863DOI Listing
December 2018
1 Read

Lysosomal Acid Lipase Deficiency Leading to Liver Cirrhosis: a Case Report of a Rare Variant Mutation.

Ann Hepatol 2018 Dec;18(1):78-88

Department of Gastroenterology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Lysosomal acid lipase deficiency is a poorly diagnosed genetic disorder, leading to accumulation of cholesterol esters and triglycerides in the liver, with progression to chronic liver disease, dyslipidemia, and cardiovascular complications. Lack of awareness on diagnosis of this condition may hamper specific treatment, which consists on enzymatic replacement. It may prevent the progression of liver disease and its complications. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7865DOI Listing
December 2018
2 Reads

Lysosomal Acid Lipase Deficiency Leading to Liver Cirrhosis: a Case Report of a Rare Variant Mutation.

Ann Hepatol 2018 Dec;18(1):230-235

Department of Gastroenterology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Lysosomal acid lipase deficiency is a poorly diagnosed genetic disorder, leading to accumulation of cholesterol esters and triglycerides in the liver, with progression to chronic liver disease, dyslipidemia, and cardiovascular complications. Lack of awareness on diagnosis of this condition may hamper specific treatment, which consists on enzymatic replacement. It may prevent the progression of liver disease and its complications. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7930DOI Listing
December 2018
1 Read

Acute papillary muscle rupture immediately after ST-segment elevation acute myocardial infarction: A case report.

J Cardiol Cases 2018 Dec 7;18(6):189-191. Epub 2018 Dec 7.

Hyogo Prefectural Awaji Medical Center, Japan.

A 73-year-old woman in cardiogenic shock was referred to our hospital because of papillary muscle rupture immediately after the onset of acute myocardial infarction (MI). She had undergone emergent percutaneous coronary intervention and mitral valve replacement. Serial creatine kinase and creatine kinase MB levels indicated that she had acute phase MI on arrival. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306573PMC
December 2018
1 Read

Impact of aortic aneurysms in trans-catheter aortic valve replacement: A single center experience.

Indian Heart J 2018 Dec 9;70 Suppl 3:S303-S308. Epub 2018 Jul 9.

Banner University Medical Center, Division of Cardiology, USA.

Background: Patients who undergo trans-catheter aortic valve replacement (TAVR) may have concomitant aortic aneurysms. We sought to clarify the incidence of aortic aneurysms and its impact on clinical outcomes among patients undergoing TAVR.

Methods: We performed a retrospective analysis of patients with severe symptomatic aortic stenosis who underwent TAVR from January 2012 to June 2016. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309288PMC
December 2018

Early-life inflammation pathways trigger a cascade leading to development of atherosclerotic plaque through the "butterfly effect" - An hypothesis.

Med Hypotheses 2019 Jan 30;122:106-110. Epub 2018 Oct 30.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland. Electronic address:

Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (especially an imbalance between pro- and anti-inflammatory macrophages) triggers a "butterfly effect" within the arterial wall by initiating a sequence of processes that finally leads to atherosclerotic plaque development and progression. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.10.026DOI Listing
January 2019

Cardiovascular risk of sitagliptin in ischemic stroke patients with type 2 diabetes and chronic kidney disease: A nationwide cohort study.

Medicine (Baltimore) 2018 Dec;97(52):e13844

Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung.

Limited data are available about the cardiovascular (CV) safety and efficacy of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in ischemic stroke patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Ischemic stroke patients with T2DM and CKD were selected from the Taiwan National Health Insurance Research Database (NHIRD) from March 1, 2009 to December 31, 2011. A total of 1375 patients were divided into 2 age- and gender-matched groups: patients who received sitagliptin (n = 275; 20%) and those who did not (n = 1,100). Read More

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http://dx.doi.org/10.1097/MD.0000000000013844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314701PMC
December 2018

Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.

Cochrane Database Syst Rev 2018 12 28;12:CD005061. Epub 2018 Dec 28.

Department of Primary and Community Care, Radboud University Nijmegen Medical Center, PO Box 9101, Nijmegen, Netherlands, 6500 HB.

Background: Alpha-glucosidase inhibitors (AGI) reduce blood glucose levels and may thus prevent or delay type 2 diabetes mellitus (T2DM) and its associated complications in people at risk of developing of T2DM.

Objectives: To assess the effects of AGI in people with impaired glucose tolerance (IGT), impaired fasting blood glucose (IFG), moderately elevated glycosylated haemoglobin A1c (HbA1c) or any combination of these.

Search Methods: We searched CENTRAL, MEDLINE, Embase, ClinicalTrials. Read More

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http://dx.doi.org/10.1002/14651858.CD005061.pub3DOI Listing
December 2018

Methamphetamine presentations to an emergency department: Management and complications.

Emerg Med Australas 2018 Dec 28. Epub 2018 Dec 28.

Clinical Toxicology Unit and Emergency Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Objective: There is little recent published data characterising methamphetamine intoxication. The present study aims to describe the clinical effects, management, complications and disposition of patients with methamphetamine exposure.

Methods: This is a retrospective review of patients presenting with methamphetamine intoxication to an ED in 2016. Read More

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http://dx.doi.org/10.1111/1742-6723.13219DOI Listing
December 2018
1 Read

Percutaneous treatment of a massive saphenous vein graft aneurysm.

Catheter Cardiovasc Interv 2018 Dec 27. Epub 2018 Dec 27.

Raigmore Hospital, Inverness, United Kingdom.

Saphenous vein graft (SVG) aneurysms are a rare, frequently late presenting, potentially fatal complication of coronary artery bypass graft (CABG) surgery. They are often discovered incidentally during radiological tasks such as chest x-ray or CT but can present clinically with symptoms such as worsening angina and breathlessness as well as complications such as rupture or myocardial infarction. Given the risks if left untreated, consideration should be given to treatment either through percutaneous routes or open surgery. Read More

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http://dx.doi.org/10.1002/ccd.28040DOI Listing
December 2018
1 Read

Outcomes and complications after fenestrated-branched endovascular aortic repair.

J Vasc Surg 2018 Dec 24. Epub 2018 Dec 24.

Division of Vascular Surgery, Department of Surgery, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Objective: To report the outcomes of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aortic aneurysms with fenestrated and/or branched devices.

Methods: This study represents a retrospective analysis of a prospectively maintained database of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aneurysms between July 2012 and July 2017. Subjects included high-risk patients for open repair and patients with unsuitable anatomy for either standard endovascular aneurysm repair or Zenith (Cook Medical, Bloomington, Ind) fenestrated device. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.052DOI Listing
December 2018
1 Read

Reactive thrombocytosis resulting from frequent blood donations as an extremely rare cause of ST Segment Elevation Myocardial Infarction in the case of a 19-year-old male.

Ann Agric Environ Med 2018 Dec 15;25(4):602-604. Epub 2017 Jul 15.

Chair and Department of Cardiology, Medical University of Lublin.

Introduction: Thrombocytosis is a disease where the platelet count exceeds 600,000/μl. It is usually reactive in nature, less often clonal. Reactive thrombocytosis is usually a response to reactive inflammation or infection, splenectomy, iron deficiency, pregnancy, physical effort or cancer. Read More

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http://dx.doi.org/10.26444/aaem/74196DOI Listing
December 2018
1 Read

Impella Support for Acute Myocardial Infarction complicated by Cardiogenic Shock: A Matched-Pair IABP-SHOCK II Trial 30-Day Mortality Analysis.

Circulation 2018 Dec 5. Epub 2018 Dec 5.

Clinic for General and interventional Cardiology, University Heart Center Hamburg, Germany.

Background: Percutaneous mechanical circulatory support devices are increasingly used in acute myocardial infarction complicated by cardiogenic shock (AMI-CS), despite limited evidence for their effectiveness. The aim of this study was to evaluate outcomes associated with use of the Impella device compared with IABP and medical treatment in patients with AMI-CS.

Methods: Data of patients with AMI-CS treated with the Impella device at European tertiary care hospitals was collected retrospectively. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036614DOI Listing
December 2018
10 Reads

Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus: A DCCT/EDIC Cohort-Based Study.

Circulation 2018 Nov 26. Epub 2018 Nov 26.

Medicine-Brigham and Women's Hospital, Joslin Diabetes Center, Harvard Medical School, UNITED STATES.

Background: Poor glycemic control is associated with increased risk of cardiovascular disease (CVD) in type 1 diabetes mellitus (T1DM); however, little is known about mechanisms specific to T1DM. In T1DM, myocardial injury can induce persistent cardiac autoimmunity. Chronic hyperglycemia causes myocardial injury, raising the possibility that hyperglycemia-induced cardiac autoimmunity could contribute to long-term CVD complications in T1DM. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036068DOI Listing
November 2018

Impact of baseline thrombocytopenia on the long-term outcome of patients undergoing elective percutaneous coronary intervention: An analysis of 9,897 consecutive patients.

Catheter Cardiovasc Interv 2018 Dec 26. Epub 2018 Dec 26.

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.

Objectives: This study aimed to investigate the association between baseline thrombocytopenia and long-term clinical outcomes among patients undergoing elective percutaneous coronary intervention (PCI).

Background: Thrombocytopenia (TP) commonly occurs among patients undergoing PCI. However, whether TP has any influence on the outcome of PCI patients remains controversial. Read More

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http://dx.doi.org/10.1002/ccd.28030DOI Listing
December 2018

Predicting onset of complications from diabetes: a graph based approach.

Appl Netw Sci 2018 15;3(1):48. Epub 2018 Nov 15.

1iCeNSA, Department of Computer Science and Engineering, University of Notre Dame, 384E Nieuwland Science Hall, Notre Dame, 46656 Indiana USA.

Diabetes is a significant health concern with more than 30 million Americans living with diabetes. Onset of diabetes increases the risk for various complications, including kidney disease, myocardial infractions, heart failure, stroke, retinopathy, and liver disease. In this paper, we study and predict the onset of these complications using a network-based approach by identifying fast and slow progressors. Read More

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http://dx.doi.org/10.1007/s41109-018-0106-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245137PMC
November 2018

Off-Pump Versus On-Pump: Long-Term Outcomes After Coronary Artery Bypass in a Veteran Population.

J Cardiothorac Vasc Anesth 2018 Nov 3. Epub 2018 Nov 3.

VA San Diego Healthcare System, Department of Surgery, Section of Cardiothoracic Surgery, San Diego, CA. Electronic address:

Objectives: The authors sought to investigate long-term outcomes after revascularization with and without use of cardiopulmonary bypass and hypothesized that off-pump would be comparable with on-pump. The primary outcome of interest was survival, and secondary outcomes were need for reintervention for revascularization or new diagnosis of myocardial infarction occurring any time after surgery during the 8- to 12-year follow-up period.

Design: Retrospective cohort analysis. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.003DOI Listing
November 2018
1 Read

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus.

Authors:
A K Pancholia

Indian Heart J 2018 Nov - Dec;70(6):915-921. Epub 2018 Sep 1.

Medicine and Preventive Cardiology, Arihant Hospital and Research Centre, Gumashta Nagar, Indore. Electronic address:

Patients with type 2 diabetes mellitus (T2DM) exhibit an increased risk for cardiovascular (CV) events. Hyperglycemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little or no impact on reducing CV risk, especially in patients with a long duration of T2DM and prevalent CV disease (CVD). Sodium-glucose cotransporter-2 (SGLT2) inhibitors are the new class of glucose-lowering medications that increase urinary glucose excretion, thus improving glycemic control, independent of insulin. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306386PMC
January 2019

Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia.

Indian Heart J 2018 Nov - Dec;70(6):772-776. Epub 2018 Jan 8.

Cardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, Tunisia.

Background: Hyperglycemia on-admission is a powerful predictor of adverse events in patients presenting for ST-elevation myocardial infarction (STEMI).

Aim: In this study, we sought to determine the prognostic value of hyperglycemia on-admission in Tunisian patients presenting with STEMI according to their diabetic status.

Methods: Patients presenting to our center between January 1998 and September 2014 were enrolled. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306357PMC
January 2019