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Cochrane Database Syst Rev 2022 05 17;5:CD010853. Epub 2022 May 17.

Department of Health Sciences, Centre for Health and Wellbeing Across the Lifecourse, Brunel University London, Uxbridge, UK.

Background: Complex regional pain syndrome (CRPS) is a painful and disabling condition that usually manifests in response to trauma or surgery and is associated with significant pain and disability. CRPS can be classified into two types: type I (CRPS I) in which a specific nerve lesion has not been identified and type II (CRPS II) where there is an identifiable nerve lesion. Guidelines recommend the inclusion of a variety of physiotherapy interventions as part of the multimodal treatment of people with CRPS. Read More

Int J Mol Sci 2022 May 6;23(9). Epub 2022 May 6.

Christian Doppler Laboratory for Innovative Immunotherapeutics, Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Vienna, Austria.

Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to counteract the potency of therapeutic antibodies that could lyse target cells by eliciting complement cascade. The manifold functions and ubiquitous expression of CRPs preclude their systemic specific inhibition. Read More

Neurol India 2022 Mar-Apr;70(2):491-503

Division of Hand Surgery, Cajuru University Hospital, Curitiba, Brazil Cajuru University Hospital, Curitiba, Brazil.

Background: Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment. One of the most devastating complications is complex regional pain syndrome.

Objectivities: The aim of this study was to systematically analyze available evidence about complex regional pain syndrome after carpal tunnel syndrome surgery (CTSS), its risks, associated factors, and treatments. Read More

Oxid Med Cell Longev 2022 14;2022:8035109. Epub 2022 Feb 14.

Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053, China.

Complex regional pain syndrome type-I (CRPS-I) represents a type of neurovascular condition featured by severe pain in affected extremities. Few treatments have proven effective for CRPS-I. Electroacupuncture (EA) is an effective therapy for pain relief. Read More

Front Immunol 2022 14;13:860165. Epub 2022 Apr 14.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

After producing triple (Gal, H-D and Sd)-KO pigs, hyperacute rejection appeared to no longer be a problem. However, the origin of xeno-rejection continues to be a controversial topic, including small amounts of antibodies and subsequent activation of the graft endothelium, the complement recognition system and the coagulation systems. The complement is activated via the classical pathway by non-Gal/H-D/Sda antigens and by ischemia-reperfusion injury (IRI), via the alternative pathway, especially on islets, and via the lectin pathway. Read More

Orthop Rev (Pavia) 2022 14;14(1):31891. Epub 2022 Feb 14.

Pain Specialists of America, Austin, TX.

Back pain is one of the most common healthcare burdens in the United States and is the number one cause of disability worldwide. Treatment options for back pain usually emphasizes conservative modalities such as reassurance, education, physical therapy, cognitive behavioral therapy, medication management, and interventional pain procedures. Spinal cord stimulation (SCS) is a minimally invasive and reversible therapy used to treat various pain syndromes. Read More

J Neurosci Res 2022 Jul 20;100(7):1487-1505. Epub 2022 Apr 20.

School of Medical Sciences and Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.

Complex regional pain syndrome (CRPS) is a painful condition commonly accompanied by movement disturbances and often affects the upper limbs. The basal ganglia motor loop is central to movement, however, non-motor basal ganglia loops are involved in pain, sensory integration, visual processing, cognition, and emotion. Systematic evaluation of each basal ganglia functional loop and its relation to motor and non-motor disturbances in CRPS has not been investigated. Read More

A A Pract 2022 Apr 11;16(4):e01579. Epub 2022 Apr 11.

From the Department of Anesthesiology and Pain Medicine, University of California, Davis Medical Center, Sacramento, California.

Arthroscopic knee surgery is a common trigger for lower extremity complex regional pain syndrome (CRPS). Few studies assess nerve block catheters for CRPS treatment; they do not appear to be studies of regional anesthesia to treat CRPS that occurs after knee surgery. We present a case of CRPS-I triggered by knee surgery on multiple prior occasions but finally prevented by perineural adductor canal catheter placement. Read More

Zhongguo Zhen Jiu 2022 Apr;42(4):385-9

Affiliated Hospital of Liaoning University of TCM, Shenyang 110032.

Objective: To assess the efficacy on relieving pain and improving the range of motion of shoulder joint in post-stroke shoulder-hand syndrome of phlegm-stasis obstruction in treatment of the combined therapy of eye acupuncture, (Chinese herbal warm dressing technique) and rehabilitation training (eye acupuncture + + rehabilitation) as compared with the combined treatment of and rehabilitation training ( + rehabilitation) and the simple rehabilitation training (rehabilitation).

Methods: A total of 356 patients with post-stroke shoulder-hand syndrome of phlegm-stasis obstruction were randomized into an eye acupuncture + + rehabilitation group (group A, 122 cases, 2 cases dropped off), a + rehabilitation group (group B, 120 cases, 3 cases dropped off) and a rehabilitation group (group C, 114 cases, 1 case dropped off). In the group C, the basic treatment was combined with routine rehabilitation training. Read More

Reg Anesth Pain Med 2022 Apr 8. Epub 2022 Apr 8.

Physical Medicine and Rehabilitation and Anesthesia, McMaster University Michael G DeGroote School of Medicine, Hamilton, Canada.

Background: Recalcitrant complex regional pain syndrome (CRPS) type 1 is a devastating condition.

Case Presentation: We report a case of a patient in their twenties with left hand and forearm CRPS type I, transiently responsive to spinal cord stimulation, thoracic sympathectomy, and multimodal analgesia. The investigators initiated a trial of a single-shot erector spinae plane block at the T2 level, resulting in a clinically significant improvement in pain, function, vasomotor and sudomotor symptoms transiently for a 36-hour interval. Read More

Jt Dis Relat Surg 2022 28;33(1):249-252. Epub 2022 Mar 28.

Karabük Eğitim ve Araştırma Hastanesi Plastik, Rekonstrüktif ve Estetik Cerrahi Kliniği, 78200 Karabük, Türkiye.

Pacinian disorders are exceedingly rare, and the exact pathogenesis is still unknown. The most common symptoms are pain, sensory changes, and a visible or palpable mass, and diagnosis is usually made by pathological examination after the excision of the painful nodule. In this case report, we present the case of a 49-year-old male with Pacinian corpuscle hyperplasia located on the metacarpophalangeal joint, emerging at the same hand of the patient two years after the treatment due to complex regional pain syndrome (CRPS). Read More

Handchir Mikrochir Plast Chir 2022 Apr 22;54(2):131-138. Epub 2022 Mar 22.

Orthopädisches Spital Speising GmbH; 1. und Kinderabteilung.

Introduction: Peripheral nerve stimulation (PNS), based on central nerve stimulation (Spinal Cord Stimulation - SCS), has proven to be a suitable therapy option for the treatment of complex regional pain syndrome (CRPS), especially in the area of the upper extremities. However, the evidence on PNS in the current literature is very scarce.

Material And Methods: 11 patients suffering from CRPS 2 were selected for implantation of a peripheral nerve stimulation system according to strict selection criteria. Read More

Schmerz 2022 Apr;36(2):141-149

Klinik und Poliklinik für Neurologie, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

Complex regional pain syndrome (CRPS) is a pain disorder that develops in the hands or feet after injury. Currently, two types are differentiated, CRPS I without and CRPS II with nerve lesions as well as with either an initially warm or an initially cold subtype, depending on the clinical symptoms. After trauma a certain amount of inflammatory reaction is considered physiological. Read More

J Proteomics 2022 May 18;260:104560. Epub 2022 Mar 18.

National Institute of Plant Genome Research, New Delhi, 110067, India.

Fusarium oxysporum f. sp. cucumerinum (FOC) infects cucumber plants, causing significant yield losses. Read More

Anaesth Rep 2022 Jan-Jun;10(1):e12150. Epub 2022 Mar 1.

Department of Anaesthesia Hospital Professor Doutor Fernando Fonseca Amadora Portugal.

Headache is common in the puerperium, with a wide variety of underlying aetiologies. We describe a unique case of postpartum headache after accidental dural puncture with a Tuohy needle in a previously healthy woman during a combined spinal-epidural for labour analgesia. Initially, a post-dural puncture headache was diagnosed. Read More

Drugs 2022 Apr 5;82(5):511-531. Epub 2022 Mar 5.

Department of Anesthesiology, Center for Pain Medicine, Erasmus MC University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

Complex regional pain syndrome (CRPS) is a debilitating painful condition of a distal extremity that can develop after tissue damage. CRPS is thought to be a multimechanism syndrome and ideally the most prominent mechanism(s) should be targeted by drugs in an individually tailored manner. This review gives an overview of the action and evidence of current and future pharmacotherapeutic options for CRPS. Read More

Perception 2022 Mar 3;51(3):187-209. Epub 2022 Mar 3.

1555University of Bath, UK.

Perceptual anomalies can provide insights into underlying pathologies even when they are not the main symptom of many clinical conditions. Complex regional pain syndrome (CRPS) and fibromyalgia are chronic pain conditions associated with changes in the central nervous system, possibly leading to enhanced visual sensitivity. It is unclear whether this occurs more than for people with other types of pain. Read More

Mov Disord Clin Pract 2022 Feb 16;9(2):156-169. Epub 2021 Dec 16.

Department of Medicine, Division of Neurology, Faculty of Medicine, Siriraj Hospital Mahidol University Bangkok Thailand.

The association of movement disorders (MDs) with musculoskeletal (MSK) disorders is observed in two principal scenarios. First, MDs patients may present with MSK issues. This phenomenon is primarily observed in parkinsonian syndromes, but may also be seen in patients with dystonia, Tourette syndrome, and some gene-related MDs. Read More

JBJS Case Connect 2021 08 12;11(3). Epub 2021 Aug 12.

Department of Orthopaedic Surgery, Geisinger Medical Center, Danville, Pennsylvania.

Case: An 11-year-old female patient presented to our clinic with a low-grade lateral ankle sprain that was subsequently treated with a lace-up ankle brace. On the reintroduction of weight bearing, the patient developed recurrent ankle pain and symptoms consistent with complex regional pain syndrome (CRPS) Type 1. On physical examination, the patient was found to have a concurrent chromhidrosis in the injured area, which is a novel presentation of CRPS. Read More

Knee Surg Sports Traumatol Arthrosc 2022 Jan 30. Epub 2022 Jan 30.

Centre PCNA, Avenue Claude Bernard, 44800, Saint-Herblain, France.

Introduction: Osteochondral lesions of the talus (OLT) are a frequent cause of pain in young patients and a new CT arthrographic classification system of OLT was recently proposed to help guide the choices of and standardize the indications for surgical treatment. The primary hypothesis was that this algorithm would result in a postoperative AOFAS score of ≥ 80/100. The secondary hypothesis was to identify the preoperative factors of successful surgery. Read More

Eur J Pain 2022 04 8;26(4):873-887. Epub 2022 Feb 8.

Centre de la Douleur, CHU Dupuytren, Limoges, France.

Background: There is no recommendation in Europe for the use of ketamine in patients with chronic pain. The heterogeneity of practice highlights the need to seek the advice of experts in order to establish a national consensus. This Delphi survey aimed to reach a national consensus on the use of ketamine in chronic pain in Pain clinics. Read More

Br J Anaesth 2022 05 26;128(5):829-837. Epub 2022 Jan 26.

Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, MO, USA; Institute for Informatics, Washington University School of Medicine in St Louis, St Louis, MO, USA.

Background: Real-time prediction of surgical duration can inform perioperative decisions and reduce surgical costs. We developed a machine learning approach that continuously incorporates preoperative and intraoperative information for forecasting surgical duration.

Methods: Preoperative (e. Read More

Neuromodulation 2022 Jan 21. Epub 2022 Jan 21.

Centre for Decision Analysis and Support, Ismar Healthcare, Lier, Belgium. Electronic address:

Objectives: To support rational decision-making on spinal cord stimulation (SCS), a European expert panel developed an educational e-health tool using the RAND/University of California at Los Angeles Appropriateness Method. This retrospective study aimed to determine the applicability and validity of the tool using data from patients for whom SCS had been considered.

Materials And Methods: A total of 12 European implant centers retrieved data from 25 to 50 consecutive patients for whom SCS was considered in 2018-2019. Read More

Front Immunol 2021 5;12:786511. Epub 2022 Jan 5.

Department of Physiology, Showa University School of Medicine, Shinagawa, Japan.

Complex regional pain syndrome (CRPS) is a chronic pain syndrome that occurs in tissue injuries as the result of surgery, trauma, or ischemia. The clinical features of this severely painful condition include redness and swelling of the affected skin. Intriguingly, it was recently suggested that transient receptor potential ankyrin 1 (TRPA1) is involved in chronic post-ischemia pain, a CRPS model. Read More

Medicine (Baltimore) 2021 Dec;100(48):e27791

Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Rationale: The α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor plays a critical role in the development and persistence of pain, and AMPA receptor antagonists are considered possible therapeutic targets for controlling pain. This report describes a patient with complex regional pain syndrome (CRPS) type I in the right lower leg and foot who responded well to perampanel, an AMPA receptor antagonist, for managing the chronic pain.

Patient Concern: A 61-year-old woman complained of pain in her right lower leg and foot over a period of 7 year (numeric rating scale: 8) due to CRPS type I. Read More

Zhongguo Zhen Jiu 2022 Jan;42(1):28-32

Department of Rehabilitation, Xuanwu Hospital of Capital Medical University.

Objective: To compare the clinical efficacy differences between - 's meridian diagnosis method combined with Bobath rehabilitation training and Bobath rehabilitation training alone for post-stroke shoulder-hand syndrome (SHS) typeⅠ.

Methods: A total of 106 patients with post-stroke SHS typeⅠwere randomly divided into an observation group (53 cases, 2 cases dropped off ) and a control group (53 cases, 3 cases dropped off ). The patients in the both groups were treated with medications for basic diseases and conventional acupuncture at Waiguan (TE 5), Shousanli (LI 10) and Jianyu (LI 15) on the affected side. Read More

Am J Clin Hypn 2022 Jan;64(3):195-205

Ludlow, VT, USA.

Complex Regional Pain Syndrome (CRPS) is a chronic, disabling condition with prolonged or excessive pain persisting in a limb usually following a triggering injury or trauma to an extremity. The subjective expression of pain is disproportionate to what would be objectively expected from the initial injury. It may also be accompanied by a variety of autonomic disturbances and trophic abnormalities such as swelling in the affected area and changes in skin color and temperature. Read More

BMC Musculoskelet Disord 2022 Jan 5;23(1):34. Epub 2022 Jan 5.

Department of Hand Surgery, Wuxi Ninth People's Hospital, Wuxi, Jiangsu, China.

Background: The aim of this prospective study was to assess the incidence of complex regional pain syndrome type I (CRPS I) in patients with scaphoid waist fracture and to explore associated factors.

Methods: This was a multicenter, prospective observational study. Demographic, imaging indicators and clinical data were collected before the conservative treatment of scaphoid waist fracture patients. Read More

Anesthesiology 2022 02;136(2):261-264

Departments of Anesthesiology and Critical Care Medicine, Neurology, Physical Medicine and Rehabilitation, and Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland; Departments of Anesthesiology and Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Eur J Pain 2022 03 5;26(3):719-728. Epub 2022 Jan 5.

Center for Interdisciplinary Pain Medicine, Department of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.

Background: Complex regional pain syndrome (CRPS) is an orphan disease occurring as a complication after trauma. Due to its acute onset and the typical clinical presentation of the inflammatory and autonomous signs, it is an eye-catching chronic pain disease affecting also young and working people. In social media and the internet, high pain severity and the unfavourable prognosis are often empathized. Read More