Search Our Scientific Publications & Authors

Sportverletz Sportschaden 2018 Dec 11;32(4):243-250. Epub 2018 Dec 11.

Muscle Research Center Erlangen, Interdisciplinary Center for Muscle Research, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

Delayed-onset muscle soreness (DOMS) is a type of ultrastructural muscle injury. The manifestation of DOMS is caused by eccentric or unfamiliar forms of exercise. Clinical signs include reduced force capacities, increased painful restriction of movement, stiffness, swelling, and dysfunction of adjacent joints. Read More

Digestion 2018 Dec 7:1-7. Epub 2018 Dec 7.

Background: Nonalcoholic-fatty-liver-disease/nonalcoholic steatohepatitis (NAFLD/NASH) is expected to become the leading liver disease worldwide. Typical liver-related complications are fibrosis, cirrhosis, and the development of hepatocellular cancer (HCC) with the need for liver transplantation. Up to now there is no approved pharmacotherapy. Read More

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

Neuroendocrinology 2018 Dec 10. Epub 2018 Dec 10.

Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexually relevant olfactory stimuli and transmit signals to alter reproductive physiology. Read More

Phys Med Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Electrical & Electronics Engineering, Bilkent University, Bilkent, Ankara, ankara, TURKEY.

Non-quadrature radio frequency (RF) excitation has been widely studied in the fields of RF shimming, local SAR estimation, and MR-EPT with the use of multi-channel transceiver arrays. These studies generally require the retrieval of the complex transmit field B₁⁺, which can be accomplished by acquiring its magnitude and phase in different steps. Magnitude of the transmit field is acquired with the conventional methods which give accurate results for both quadrature and non-quadrature excitations. Read More

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, McMaster University, Center for Advanced Micro-Electro-Fluidics, 1280 Main Street West, Hamilton, Ontario, CANADA L8S 4L7, Hamilton, CANADA.

One of the primary focuses in recent years in tissue engineering has been the fabrication and integration of vascular structures into artificial tissue constructs. However, most available methodologies lack the ability to create multi-layered concentric conduits inside natural extracellular matrices (ECMs) and gels that replicate more accurately the hierarchical architecture of biological blood vessels. In this work, we present a new microfluidic nozzle design capable of multi-axial extrusion in order to 3D print and pattern bi- and tri-layered hollow channel structures. Read More

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

University of Utah, Salt Lake City, Utah, UNITED STATES.

Understanding how liquid polymer interacts with and spreads on surfaces with nanoscale texture features is crucial for designing complex nanoscale systems. We use molecular dynamics to simulate different types of polymer as they spread on substrates with a single nanoscale groove. We study how groove design affects the potential energy of a substrate and how this governs polymer spreading and orientation. Read More

Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.

Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:

Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.

Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More

J Colloid Interface Sci 2018 Dec 3;538:489-498. Epub 2018 Dec 3.

Department of Chemistry, Arba Minch University, Ethiopia.

Herein, we have explored the conformational alterations of hemoglobin (Hb) in presence of a cleavable gemini surfactant (C16-C4O2-C16). The concerned surfactant was found to induce significant structural perturbations in Hb. UV-vis spectroscopy, steady-state/time-resolved fluorescence, and other utilized techniques have authenticated the complexation of Hb with the gemini surfactant. Read More

J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.

Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:

Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More

J Neurol Sci 2018 Dec 4;396:262-265. Epub 2018 Dec 4.

Division of General Medicine and Geriatrics, Department of Medicine, Emory School of Medicine, 1648 Pierce Dr. NE, Atlanta, GA 30307, USA; Atlanta VA Center for Visual and Neurocognitive Rehabilitation, 1670 Clairmont Rd., Decatur, GA 30033, USA; Department of Rehabilitation Medicine, Emory School of Medicine, 1648 Pierce Dr. NE, Atlanta, GA 30307, USA. Electronic address:

Introduction: Parkinson's disease (PD) is a neurodegenerative condition associated with aging characterized by loss of dopamine-producing neurons in the substantia nigra pars compacta and a reduction in dopamine levels in the striatum. PD is commonly treated using dopamine-replacement medication called levodopa. Levodopa has decreasing efficacy over time. Read More

Colloids Surf B Biointerfaces 2018 Dec 4;175:231-238. Epub 2018 Dec 4.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Conventional chemotherapy suffers from several drawbacks, including toxic side effects together with the development of resistance to the chemical agents. Therefore, exploring alternative therapeutic approaches as well as developing targeted delivery systems are in demand. Oligonucleotide-based therapy has emerged as a promising and alternative procedure for treating malignancies involving gene-related diseases. Read More

J Plant Physiol 2018 Nov 20;232:94-99. Epub 2018 Nov 20.

Institute of Basic Biological Problems of Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

The carrier of carbonic anhydrase (CA) activity was detected in gel among low molecular mass proteins from pea, spinach and Arabidopsis, after nondenaturing electrophoresis in PAAG of the dodecyl-β-d-maltoside treated PSII membranes (the fragments of thylakoid membrane containing PSII complexes). The elimination of Mn-stabilizing protein PsbO by treatment of PSII membranes with salts, did not lead to a decrease in CA activity observed in the gel although it reduced the amount of this protein down to 25% compared to the original sample. The isolated protein PsbO did not demonstrated CA activity. Read More

J Plant Physiol 2018 Nov 16;232:141-150. Epub 2018 Nov 16.

Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou Hainan 571101, China; College of Life Sciences, Key Laboratory for Ecology of Tropical Islands, Ministry of Education, Hainan Normal University, Haikou, Hainan 571158, China. Electronic address:

Sesuvium portulacastrum, an important mangrove-associated true halophyte belongs to the family Aizoaceae, has excellent salt tolerance. Chloroplasts are the most sensitive organelles involved in the response to salinity. However, the regulation mechanism of chloroplasts of S. Read More

Eval Program Plann 2018 Dec 4;73:71-79. Epub 2018 Dec 4.

Center for Research on Lifelong STEM Learning, Oregon State University, 254 Gilbert Hall, Corvallis, OR, 97331, United States. Electronic address:

Networks are a promising mechanism for creating systemic change. Studies abound, but do not examine roles and practices to reveal the processes through which networks create transformative capacity. This participatory single case study provides a framework to examine structures, roles and practices. Read More

Neuroimage 2018 Dec 8. Epub 2018 Dec 8.

Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Adaptive emotion processing is critical for nearly all aspects of social and emotional functioning. There are distinct developmental trajectories associated with improved emotion processing, with a protracted developmental course for negative or complex emotions. The specific changes in neural circuitry that underlie this development, however are still scarcely understood. Read More

Biol Blood Marrow Transplant 2018 Dec 8. Epub 2018 Dec 8.

Cleveland Clinic Foundation, Cleveland, OH.

HLA haplotype mismatches have been associated with higher risk of acute graft versus host disease (aGVHD) in patients receiving HLA matched unrelated donor (URD) hematopoietic cell transplant (HCT) unrelated donors. The Gamma block (GB) is located in the central MHC region between beta and delta blocks (encoding C & B and DR & DQ antigens, respectively). GB contains many inflammatory and immune regulatory genes such as Bf, C2 and C4 genes. Read More

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. Read More

J Pediatr Adolesc Gynecol 2018 Dec 8. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, 7435A-555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Background: The Mirena levonorgestrel intrauterine system (IUS) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was utilized in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology & Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, Ohio, USA. Electronic address:

Preclinical evidence suggests that ketamine's rapid and sustained antidepressant actions are due to the induction of synaptogenesis in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP), two brain regions implicated in the pathophysiology of major depression. However, research on the neurobiological effects of ketamine has focused almost exclusively on males. Findings from our group and others indicate that female rodents are more reactive to ketamine's antidepressant effects, since they respond to lower doses in antidepressant-predictive behavioral models. Read More

Biochim Biophys Acta Bioenerg 2018 Dec 8. Epub 2018 Dec 8.

Laboratory of Biophysics, Wageningen University, Wageningen, the Netherlands; MicroSpectroscopy Research Facility, Wageningen University, Wageningen, the Netherlands. Electronic address:

During the millions of years of evolution, photosynthetic organisms have adapted to almost all terrestrial and aquatic habitats, although some environments are obviously more suitable for photosynthesis than others. Photosynthetic organisms living in low-light conditions require on the one hand a large light-harvesting apparatus to absorb as many photons as possible. On the other hand, the excitation trapping time scales with the size of the light-harvesting system, and the longer the distance over which the formed excitations have to be transferred, the larger the probability to lose excitations. Read More

Biochem Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

Université Paris-Est, Laboratoire CRRET ERL-CNRS 9215, UPEC, F-94010, Créteil, France. Electronic address:

Pharmaceuticals and their by-products are increasingly a matter of concern, because of their unknown impacts on human health and ecosystems. The lack of information on these transformation products, which toxicity may exceed that of their parent molecules, makes their detection and toxicological evaluation impossible. Recently we characterized the Pyridinium of furosemide (PoF), a new transformation product of furosemide, the most widely used diuretic and an emerging pollutant. Read More

J Oncol Pract 2018 Dec;14(12):e758-e769

Sarah Cannon Cancer Institutes at HCA Midwest Health, Overland Park, KS; University of Florida College of Medicine; Malcom Randall Veterans Affairs Medical Center, Gainesville; Florida Cancer Specialists, Deland, FL; University of Texas Southwestern Medical Center, Dallas, TX; and Cleveland Clinic Akron General, Akron, OH.

Purpose:: Meaningful connections are an important aspect of career satisfaction. The Hematology Oncology Women Physician Group (HOWPG) is a private Facebook (FB) group of 936 women who practice within the hematology/oncology (H/O) field. We hypothesized that HOWPG adds value to education, emotional wellness, and practice of oncology for its membership. Read More

Int J Nurs Pract 2018 Dec 9:e12714. Epub 2018 Dec 9.

Department of Rural Health, University of Newcastle, Taree, Australia.

Aims: To synthesize the scientific evidence about new graduate nurses' transition to practice in the acute care setting and consider implications for nurses and nursing practice.

Background: Despite the vast amount of literature on new graduate nurses' transition to practice, the transition of new graduate nurses is a global issue and remains at the forefront of discussions within the nursing community.

Design: An integrative review. Read More

Pest Manag Sci 2018 Dec 10. Epub 2018 Dec 10.

Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS, CSIC), Avenida Reina Mercedes 10, 41012 Sevilla, Spain.

Background: Imazaquin is a chiral herbicide which displays high mobility in soils. Like other imidazolinones, imazaquin is available for use only as racemic mixture of its enantiomers. In this work, several clay materials were assayed as adsorbents of imazaquin, and then the most suitable material was selected to prepare a clay-based slow release imazaquin nanoformulation containing exclusively the biologically active R-enantiomer. Read More

Genesis 2018 Dec 10:e23269. Epub 2018 Dec 10.

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Investigation of Drosophila oogenesis provides the opportunity to understand conservative genetic mechanisms underlying fertile female gamete development. In this work, we showed that the Drosophila DNA-binding protein GAGA factor (GAF) had a multifunctional role in oogenesis and it is involved in the regulation of this process genetic program. We studied the influence on Drosophila oogenesis of a number of mutations in the 5' region of the Trl gene that encodes GAF. Read More

Chemistry 2018 Dec 11. Epub 2018 Dec 11.

UNITED KINGDOM.

This study details attempts to access N-heterocyclic carbenes (NHCs) featuring the diazaborolyl group, {(HCNDipp)2B}, as one or both of the N-bound substituents. Attempts to isolate N-heterocyclic carbenes based around imidazolylidene or related heterocycles, are characterized by facile N-to-C migration of the boryl substituent. In the cases of imidazolium precursors bearing one N-bound diazaboryl group and one methyl substituent, deprotonation leads to the generation of the target carbenes, which can be characterized in situ by NMR measurements, and trapped by reactions with metal fragments and elemental selenium. Read More

Plant J 2018 Dec 7. Epub 2018 Dec 7.

The Laboratory of Seed Science and Technology, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Collaborative Innovation Center for Modern Crop Production, Nanjing Agricultural University, Nanjing, 210095, PR China.

Seed germination is a complex trait determined by both quantitative trait loci (QTLs) and environmental factors and also their interactions. In this study, we mapped one major QTL qSE3 for seed germination and seedling establishment under salinity stress in rice. To understand the molecular basis of this QTL, we isolated qSE3 by map-based cloning and found that it encodes a K transporter gene, OsHAK21. Read More

Neurogastroenterol Motil 2018 Dec 11:e13521. Epub 2018 Dec 11.

Center for Motility and Gastrointestinal Functional Disorders, Division of Gastroenterology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: We evaluated the changes in antroduodenal manometry (ADM) parameters and interpretation when the test is performed the day of catheter placement and the following day.

Methods: Catheter was placed endoscopically under anesthesia and recorded on day 1 and repeated on day 2. Study parameters including antrum and small bowel motility index (MI) during fasting, meal, postprandial, erythromycin (EES), and octreotide (OCT) challenge phases, the presence of the phase III of the migrating motor complex (MMC), visual postprandial response, and study interpretation were compared between both days. Read More

Chemistry 2018 Dec 7. Epub 2018 Dec 7.

Fudan University, Department of Chemistry, No.2005 Songhu Road, Yangpu District,, 200438, Shanghai, CHINA.

Mononuclear amidinate yttrium complex C₄H₉C(NR)₂Y(o-CH₂C₆H₄NMe₂)₂ (R = 2,6-iPr₂C₆H₃) and a series of binuclear rare-earth-metal complexes bearing a bridged amidinate ligand [(RN)₂C(CH₂)₄C(NR)₂][Ln(CH₂C₆H₄(o-NMe₂))₂]₂(R = 2,6-iPr₂C₆H₃, Ln = Y, Lu, Sc) were synthesized and fully characterized. The catalytic behavior of these complexes for (co)polymerization of conjugated dienes such as isoprene and myrcene in the presence of cocatalyst [Ph₃C][B(C₆F₅)₄] was investigated. These catalytic systems show impressive high activity and 3,4 regio-selectivity in livingness fashion. Read More

Adv Healthc Mater 2018 Dec 11:e1801076. Epub 2018 Dec 11.

Department of Biomedical Engineering, Pratt School of Engineering, Duke University, 101 Science Drive, Durham, NC, 27705, USA.

Brain tumors remain a great clinical challenge, in part due to their capacity to invade into eloquent, inoperable regions of the brain. In contrast, inflammation in the central nervous system (CNS) due to injuries activates microglia and astrocytes culminating in an astroglial scar that typically "walls-off" the injury site. Here, the hypothesis is tested that targeting peritumoral cells surrounding tumors to activate them via an inflammatory stimulus that recapitulates the sequelae of a traumatic CNS injury, could generate an environment that would wall-off and contain invasive tumors in the brain. Read More

Genet Epidemiol 2018 Dec 9. Epub 2018 Dec 9.

Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland.

We develop linear mixed models (LMMs) and functional linear mixed models (FLMMs) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effects of a major gene are modeled as a fixed effect, the contributions of polygenes are modeled as a random effect, and the correlations of pedigree members are modeled via inbreeding/kinship coefficients. -statistics and χ likelihood ratio test (LRT) statistics based on the LMMs and FLMMs are constructed to test for association. Read More

J Leukoc Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.

Leukocytes are constantly produced in the bone marrow and released into the circulation. Many different leukocyte subpopulations exist that exert distinct functions. Leukocytes are recruited to sites of inflammation and combat the cause of inflammation via many different effector functions. Read More

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

β-d-Mannuronic acid (M2000), a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties, has been previously shown to exhibit potential therapeutic effects on autoimmune diseases. Immunosuppression therapy has been a standard approach for myelodysplastic syndrome (MDS) for many years. We evaluated the effect of M2000 on isolated peripheral blood mononuclear cells (PBMCs) from patients with MDS. Read More

Glob Chang Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Biology, Trani Center for Life Sciences, Virginia Commonwealth University, Richmond, Virginia.

Sea level rise and changes in precipitation can cause saltwater intrusion into historically freshwater wetlands, leading to shifts in microbial metabolism that alter greenhouse gas emissions and soil carbon sequestration. Saltwater intrusion modifies soil physicochemistry and can immediately affect microbial metabolism, but further alterations to biogeochemical processing can occur over time as microbial communities adapt to the changed environmental conditions. To assess temporal changes in microbial community composition and biogeochemical activity due to saltwater intrusion, soil cores were transplanted from a tidal freshwater marsh to a downstream mesohaline marsh and periodically sampled over 1 year. Read More

Obes Rev 2018 Dec 10. Epub 2018 Dec 10.

Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.

Obesity is a major problem in the modern world causing a higher risk for various cerebrovascular diseases causing a profound individual and societal burden. The neurobiological foundation bears potential to understand the complex interaction of individual differences in brain structure and function and ingestive behaviour. This systematic review was performed on the current evidence of structural abnormalities in grey matter volume (GMV) in patients with obesity based on studies published until December 2017, which were selected through search in PubMed, CENTER (Cochrane Library), PsycINFO, Web of Science, and Ovid MEDLINE. Read More

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Universität Gießen, Heinrich-Buff-Ring 58, 35392, Gießen, GERMANY.

LiNiO₂ (LNO) has been introduced as cathode active material (CAM) for Li-ion batteries in 1990. After years of intensive research, it emerged that several instability issues plague the material, so that it was abandoned in favor of isostructural metal-substituted compounds called NCA (for lithium nickel cobalt aluminum oxide) and NCM (lithium nickel cobalt manganese oxide). These sacrifice a certain amount of specific energy in exchange for stability, durability and safety. Read More

Plant J 2018 Dec 7. Epub 2018 Dec 7.

University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New, Delhi-110078, India.

In flowering plants LIKE HETEROCHROMATIN PROTEIN 1 (LHP1)/TERMINAL FLOWER 2 (TFL2) is known to interact with polycomb group (PcG) and non-PcG proteins and control developmental programs. LHP1/TFL2 is an ancient protein and has been characterized in the early-divergent plant Physcomitrella patens. However, interacting partners of PpLHP1 other than the chromomethylase PpCMT have not been identified to date. Read More

Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Multiple drug classes have shown incremental benefits in heart failure with reduced ejection fraction. Most of these trials were designed to achieve specific doses of the investigational agent. Clinical practice guidelines recommend using the same target dosing of therapies, as tolerated. Read More

Plant J 2018 Dec 8. Epub 2018 Dec 8.

Department of Animal, Plant and Soil Science, School of Life Science, Australian Research Council Centre of Excellence in Plant Energy Biology, La Trobe University, 5 Ring Road, Bundoora, 3086, Victoria, Australia.

Plants respond to short- and long-term mechanical stimuli, via altered transcript abundance and growth respectively. Jasmonate, gibberellic acid and calcium have been implicated in mediating responses to mechanical stimuli. Previously it was shown that the transcript abundance for the outer mitochondrial membrane protein of 66 kDa (OM66), is induced several-fold after 30 min in response to touch. Read More

Biofactors 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, Japan.

Human sirtuin 1 (hSIRT1) is a NAD -dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)-hopeaphenol ((+)-HP), and its geometric isomer, (-)-isohopeaphenol ((-)-iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53-AMC (Fluor de Lys) and a cofactor NAD . Read More

Small 2018 Dec 11:e1803478. Epub 2018 Dec 11.

NC State University, Raleigh, NC, 27695-8202, USA.

Complex manipulations of DNA in a nanofluidic device require channels with branches and junctions. However, the dynamic response of DNA in such nanofluidic networks is relatively unexplored. Here, the transport of DNA in a 2D metamaterial made by arrays of nanochannel junctions is investigated. Read More

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide. Despite the substantial advancement in understanding the molecular mechanisms and management of BC, it remains the leading cause of cancer death in women. One of the main reasons for this obstacle is that we have not been able to find the Achilles heel for the BC as a highly heterogeneous disease. Read More

Genes Chromosomes Cancer 2018 Dec 9. Epub 2018 Dec 9.

Physics Department & Nanotechnology Institute, Bar Ilan University, Ramat Gan, Israel.

During the past three decades, the study of nuclear and chromatin organization has become of great interest. The organization and dynamics of chromatin are directly responsible for many functions including gene regulation, genome replication, and maintenance. In order to better understand the details of these mechanisms, we need to understand the role of specific proteins that take part in these processes. Read More

J Cell Physiol 2018 Dec 8. Epub 2018 Dec 8.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.

Irradiation (IR) can be used to treat cancer by inducing complex and irreparable DNA damage in the cancer cells, which may lead to their apoptotic death. However, little is known about the molecular mechanism of this DNA damage. Here, the non-small-cell lung cancer cell line A549 was treated with either X-ray or carbon ion combined with bleomycin (BLM). Read More

Evolution 2018 Dec 8. Epub 2018 Dec 8.

School of Earth Sciences, University of Bristol, Life Sciences Building, Bristol, UK.

Extensive research on avian adaptive radiations has led to a presumption that beak morphology predicts feeding ecology in birds. However, this ecomorphological relationship has only been quantified in a handful of avian lineages, where associations are of variable strength, and never at a broad macroevolutionary scale. Here, we used shape analysis and phylogenetic comparative methods to quantify the relationships between beak shape, mechanical advantage, and two measures of feeding ecology (feeding behaviour and semi-quantitative dietary preferences) in a broad sample of modern birds, comprising most living orders. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Transforming growth factor (TGF)-β is a multitasking cytokine such that its aberrant expression is related to cancer progression and metastasis. TGF-β is produced by a variety of cells within the tumor microenvironment (TME), and it is responsible for regulation of the activity of cells within this milieu. TGF-β is a main inducer of epithelial-mesenchymal transition (EMT), immune evasion, and metastasis during cancer progression. Read More

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. Read More

Traffic 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry, McGill University, Quebec, Canada.

Endocytic sorting of activated receptor tyrosine kinases (RTKs), alternating between recycling and degradative processes, controls signal duration, location, and surface complement of RTKs. The Microtubule (MT) plus-end tracking proteins (+TIPs) play essential roles in various cellular activities including translocation of intracellular cargo. However, mechanisms through which RTKs recycle back to the plasma membrane following internalisation in response to ligand remain poorly understood. Read More