Search Our Scientific Publications & Authors

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Pain Unit, Anesthesiology and Resuscitation Department, University Care Complex of Salamanca (Complejo Asistencial Universitario de Salamanca), Salamanca, Spain.

Objective: One of the physiopathological hypothesis behind complex regional pain syndrome (CRPS) type I involves the deep-tissue hypoxia of the affected areas. Spinal cord stimulation (SCS) appears to be effective in the treatment of these patients. We evaluated whether ESCS modifies tissue oxygen saturation (StO ) measured with near-infrared spectroscopy (NIRS) in the affected limbs in patients diagnosed with CRPS type I. Read More

J Altern Complement Med 2019 Feb;25(2):141-168

1 National Centre for Naturopathic Medicine, Southern Cross University, Lismore, Australia.

Objective: To summarize the current state of the research evidence for whole-system, multi-modality naturopathic medicine.

Design: A systematic search for research articles from around the world was undertaken using MEDLINE, Embase, CINAHL, AMED, and WHO regional indexes. Naturopathic journals and gray literature were hand searched. Read More

Reg Anesth Pain Med 2019 Mar;44(3):376-387

Department of Pain Management, Cleveland Clinic, Cleveland, OH 44024, USA

This account of the condition now termed complex regional pain syndrome (CRPS) spans approximately 462 years since a description embodying similar clinical features was described by Ambroise Paré in 1557. While reviewing its historical origins, the text describes why it became necessary to change the taxonomies of two clinical syndromes with similar pathophysiologies to one which acknowledges this aspect but does not introduce any mechanistic overtones. Discussed at length is the role of the sympathetic component of the autonomic nervous system (ANS) and why its dysfunction has both directly and indirectly influenced our understanding of the inflammatory aspects of CRPS. Read More

J Surg Orthop Adv 2018 ;27(4):261-268

Department of Orthopaedic Surgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina; e-mail:

Ascorbic acid (vitamin C) is an essential micronutrient with evidence supporting its role in bone formation, tissue repair, and collagen production. Its clinical importance to the field of orthopaedic surgery has yet to be fully defined. Several observational studies have shown improved bone density and reduced hip fracture risk with supplementation. Read More

Joint Bone Spine 2019 Feb 15. Epub 2019 Feb 15.

Centre de rhumatologie, hôpital Pierre-Paul-Riquet, CHU de Toulouse, place du Dr-Baylac, TSA 40 031, 31059 Toulouse cedex 9, France; Centre de Physiopathologie Toulouse Purpan, INSERM UMR 1043, CHU Purpan, BP 3028, 31024 Toulouse cedex 3, France.

Pain Med 2019 Feb 18. Epub 2019 Feb 18.

Center for Pain Medicine, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.

Objective: Although complex regional pain syndrome (CRPS) of the knee is comparable to CRPS of the ankle/foot at time of diagnosis, no reports are available concerning the course of knee CRPS. Therefore, this study investigated the clinical course in terms of the symptoms and signs, health-related quality of life (HR-QoL), and work status of patients diagnosed with CRPS of the knee.

Design: Observational, descriptive study. Read More

J Neurosurg 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Plastic & Reconstructive Surgery, Radboud University Medical Center, Nijmegen.

OBJECTIVEThe aim of this study was to evaluate the self-reported outcome of revision surgery in patients with recurrent and persistent carpal tunnel syndrome (CTS) and to identify predictors of clinical outcome of revision surgery.METHODSA total of 114 hands in 112 patients were surgically treated for recurrent and persistent CTS in one of 10 specialized hand clinics. As part of routine care, patients were asked to complete online questionnaires regarding demographic data, comorbidities, and clinical severity measures. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14452

Department of Psychiatry, Seoul National University Hospital.

Complex regional pain syndrome (CRPS) and fibromyalgia (FM) share many features. Both can cause severe pain and are considered to have a mechanism of action, including dysfunction of the sympathetic nervous system. However, they have clinical differences in pain range and degree. Read More

Pain 2019 Feb 8. Epub 2019 Feb 8.

Dept. of Endocrine Research, Medical Hospital I, BG University Hospitals Bergmannsheil Bochum.

Local osteopenia and altered bone metabolism are major complications of complex regional pain syndrome (CRPS), but quantitative assessment is difficult unless using X-ray or dual-energy X-ray absorptiometry. Ultrasound-based measurement of bone density (UBD) is a possible alternative, but has never been used to detect unilateral disease such as CRPS. Therefore, the main outcome measure of this prospective study was the diagnostic utility of UBD in patients with lower limb CRPS. Read More

Urologiia 2018 Dec(6):108-114

FGBOU VO Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky of the Ministry of Health of Russia, Krasnoyarsk, Russia.

Aim: to study the course of chronic abacterial prostatitis with the inflammatory component (CAPIC) depending on the somatotype in men of the first period of mature age taking complex treatment with a use of local and systemic ozone therapy.

Materials And Methods: A total of 306 men of asthenic, normostenic and pyknic somatotypes with CAPIC were followed-up. Along with standard therapy, all patients received systemic and local ozone therapy. Read More

Urologiia 2018 Dec(6):101-106

Department of Polyclinic Therapy and Medical Rehabilitation with the course of Additional Professional Education Federal State Educational Institution of Higher Education Altai State Medical University of the Ministry of Health of the Russian Federation, Barnaul, Russia.

The aim of the study was to increase the efficiency of complex treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with the combined effect of magnetolaser therapy (MLT) and red light.

Materials And Methods: We examined and included in the study 120 men with a verified diagnosis of CP/CPPS (III B), at the stage of exacerbation. By envelope method, patients were divided into two randomized groups. Read More

Eur J Pain 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Complex Regional Pain Syndrome (CRPS) is much more prevalent in women than men but potential differences in clinical phenotype have not been thoroughly explored to date. Differences in the clinical presentation between sexes may point at new avenues for a more tailored management approach of CRPS. We therefore explored if in CRPS the patient's sex is associated with differences in clinical and psychological characteristics. Read More

J Hand Surg Am 2019 Feb 4. Epub 2019 Feb 4.

Department of Orthopaedic Surgery, Southern California Permanente Medical Group, Anaheim, CA. Electronic address:

Purpose: Osteotomy of the distal radius for a fracture malunion is a challenging procedure. The purpose of this study was to review a series of osteotomies to determine the type and risk of complications.

Methods: A retrospective cohort study was performed, including all Kaiser Permanente Southern California patients who were aged 18 years or older between January 1, 2007, and September 25, 2015, and underwent osteotomy for an extra-articular distal radius fracture malunion. Read More

Anaesthesist 2019 Feb;68(2):115-128

Klinik und Poliklinik für Neurologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55101, Mainz, Deutschland.

The acute phase of complex regional pain syndrome (CRPS) is pathophysiologically characterized by an activation of the immune system and its associated inflammatory response. During the course of CRPS, central nervous symptoms like mechanical hyperalgesia, loss of sensation, and body perception disorders develop. Psychological factors such as pain-related anxiety and traumatic events might have a negative effect on the treatment outcome. Read More

Knee 2019 Jan 31. Epub 2019 Jan 31.

Centre Albert Trillat, Service de Chirurgie Orthopédique, Hôpital Universitaire Lyon Nord, Lyon, France.

Patella infera is an uncommon but potentially crippling pathology of the knee, resulting in stiffness and anterior knee pain. Several surgical methods have been described for its treatment, but there remains no clear technique of choice. We present the case of a 63-year-old male with patella infera, affecting a native knee, following Complex Regional Pain Syndrome. Read More

J Pain 2019 Jan 30. Epub 2019 Jan 30.

Functional Imaging Unit, Center for Diagnostic Radiology, University of Greifswald, Germany. Electronic address:

Spatial integration of parts of the body is impaired in patients with complex regional pain syndrome (CRPS). Since the training of mental rotation (MR) has been shown to be among the effective therapy strategies for CRPS, impairment of MR is also important for the pathophysiological understanding of CRPS. The aim of this study was to evaluate whether differences in neural representation of MR occur between CRPS patients and healthy controls. Read More

World Neurosurg 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurological Surgery, Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Center for Neurological Restoration, Neurologic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Objective: Spinal cord stimulation (SCS) is both relatively safe and reversible. Although SCS is generally regarded as a last resort, some of these patients will have additional spinal surgery after the device is implanted or following its removal. The following is a descriptive study of subsequent spinal surgery following SCS. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14282

Department of Anesthesiology and Pain Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Pulsed radiofrequency (PRF) to the thoracic sympathetic ganglion (TSG PRF) or to the cervical sympathetic chain (CSC PRF) can be performed to overcome transient effects of single sympathetic blocks in patients with upper-extremity complex regional pain syndrome (CRPS).We retrospectively compared the clinical effects of TSG PRF and CSC PRF. Seven TSG PRF cases and 10 CSC PRF cases were enrolled in the present analysis. Read More

Pain 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Complex Regional Pain Syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation which is explained by local and systemic activation of a pro-inflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin converting enzyme (ACE) in patients treated for hypertension increases the odds to develop CRPS. Read More

Physiother Theory Pract 2019 Jan 27:1-21. Epub 2019 Jan 27.

a Physiotherapy Department , University of Witwatersrand , Johannesburg , South Africa.

Background: Treatment of chronic pain is challenging and there is often failure of recovery, with the need to look at different approaches in its management. Central mechanisms may contribute to chronicity (i.e. Read More

Br J Pain 2019 Feb 13;13(1):35-42. Epub 2018 Jun 13.

SI 'Institute of Traumatology and Orthopedics of the Academy of Medical Sciences of Ukraine', Kyiv, Ukraine.

Introduction: Mirror therapy requires a minimum of equipment, is relatively simple to perform and effective for various pathological conditions. The effect of mirror therapy on body schema disturbances registered in complex regional pain syndrome type I (CRPS I) patients has not yet been determined.

Methods: The study is based on the analysis of the treatment results of 30 patients with CRPS I, developed as a result of the distal radius fractures, with help of mirror therapy together with exercise therapy and medications. Read More

Korean J Pain 2019 Jan 2;32(1):47-50. Epub 2019 Jan 2.

Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.

Background: It is uncommon for patients who have received a permanent implant to remove the spinal cord stimulator (SCS) after discontinuation of medication in complex regional pain syndrome (CRPS) due to their completely painless state. This study evaluated CRPS patients who successfully removed their SCSs.

Methods: This 10-year retrospective study was performed on patients who had received the permanent implantation of an SCS and had removed it 6 months after discontinuation of stimulation, while halting all medications for neuropathic pain. Read More

Toxicon 2019 Mar 17;159:41-44. Epub 2019 Jan 17.

Department of Physical and Rehabilitation Medicine, University of Padova, Via Giustiniani 3, 35128, Padova, Italy.

Complex regional pain syndrome (CRPS) is characterized by hyperalgesia, autonomic and trophic alterations of bones, muscles and skin. It is supported by neurogenic inflammation and impairment of sympathetic nervous system. Botulinum Toxin (BTX) is an option for the management of pain, with level B evidence of efficacy in neuropathic, joint and myofascial pain syndrome. Read More

Am J Emerg Med 2019 Jan 11. Epub 2019 Jan 11.

Emergency Department, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.

Erector spinae plane block (ESPB) is a novel block where local anesthetic is deposited between the erector spinae muscle and the underlying transverse process. Safety of this technique is emphasized in the majority of reports, but with a continued increase of its use, the number of related complications and side effects is likely to expand. We report the case of a patient treated with ESPB for a complex regional pain syndrome, complicated by the development of a priapism. Read More

Reg Anesth Pain Med 2019 Jan;44(1):111-117

Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois, USA

Background And Objectives: Ketamine has been shown to reduce chronic pain; however, the adverse events associated with ketamine makes it challenging for use outside of the perioperative setting. The ketamine metabolite (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) has a therapeutic effect in mice models of depression, with minimal side effects. The objective of this study is to determine if (2R,6R)-HNK has efficacy in both acute and chronic mouse pain models. Read More

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, United States. Electronic address:

Complex regional pain syndrome (CRPS) has been considered to be an autoimmune disease and there have been clinical trials with intravenous immunoglobulin. Often the etiology of the so-called CRPS diagnosis cannot be discerned and there are no validated instruments that provide functional metrics. The term complex regional pain syndrome (CRPS), coined in 1994 to describe patients in whom the pain is out of proportion to the injury, was actually a diagnosis proposed during the American Civil War, but was originally known as causalgia. Read More

Br J Neurosurg 2019 Jan 12:1-3. Epub 2019 Jan 12.

b Senior Consultant Neurosurgeon, Institute of Neurosciences, Medanta The Medicity , Gurgaon , Haryana , India.

Background: Complex regional pain syndrome (CRPS) is a chronic neuropathic painful condition, sometimes associated with spinal myoclonus. For intractable cases spinal cord stimulation is an important modality of treatment but the response of specifically myoclonus to this treatment is not well described.

Case Description: A 40-year old male, had a history of trauma 12 years back since when he had intractable neuropathic pain in his both upper limbs with superimposed severely disabling myoclonic jerks. Read More

Eur J Pain 2019 Jan 8. Epub 2019 Jan 8.

European Pain Federation, Brussels, Belgium.

Background: Complex regional pain syndrome is a painful and disabling post-traumatic primary pain disorder. Acute and chronic complex regional pain syndrome (CRPS) are major clinical challenges. In Europe, progress is hampered by significant heterogeneity in clinical practice. Read More

Clin Auton Res 2019 Jan 1. Epub 2019 Jan 1.

Department of Anesthesiology and Pain Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero, Seoul, 137-701, Republic of Korea.

Local Reg Anesth 2018 11;11:129-136. Epub 2018 Dec 11.

Graf Biostatistics, CH-8400 Winterthur, Switzerland.

Objectives: The efficiency of local anesthetics (LAs) in the treatment of peripheral pain is commonly attributed to their capacity to block the axon conduction of sensory nerves. LAs even in non-blocking concentration suppress oscillations of the resting membrane potential. Spiking in sensory neurons is triggered by subthreshold membrane potential oscillations (SMPOs), which reach threshold and is maintained by depolarizing impulse after oscillations. Read More

Eur J Pain 2018 Dec 24. Epub 2018 Dec 24.

Klinik und Poliklinik für Neurologie, Unimedizin Mainz, Mainz, Germany.

Background: Hypersensitivity and altered sweating are often present in neuropathy patients. Nerve lesions are known to produce sudomotor dysfunctions but also patients suffering from complex regional pain syndrome, CRPS1-a condition without a nerve lesion-present with sweating disorders.

Methods: Using proton nuclear magnetic resonance of sweat water, we quantified sweat output of mice suffering from a nerve lesion or a bone fracture without nerve lesion and correlated their sweating with behavioural paw hypersensitivity accessed in von Frey testings, water applications and weight-bearing measured with an incapacitance metre. Read More

J Plast Reconstr Aesthet Surg 2019 Feb 16;72(2):335-354. Epub 2018 Dec 16.

Department of PLastic Surgery, North Bristol NHS Trust, BS10 5DN, United KIngdom. Electronic address:

J Plast Reconstr Aesthet Surg 2019 Feb 15;72(2):335-354. Epub 2018 Dec 15.

Department of Surgery, Division of Plastic & Reconstructive Surgery, University of California, Davis, 2221 Stockton Blvd, Ste. E, Sacramento, CA, United States.

Transplant Proc 2018 Dec 8;50(10):4090-4095. Epub 2018 Sep 8.

Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China.

Background: Calcineurin-inhibitor-induced pain syndrome (CIPS), a rare complication seen in patients with bone marrow transplants, is associated with the use of cyclosporine A (CsA) or tacrolimus (FK506). This case demonstrates the successful pain control of FK506-related CIPS in a 23-year-old male patient with previously reported characteristic clinical features of CIPS in addition to neuropathic symptoms and uncharacteristic imaging findings. On day 15 after the transplantation, the patient complained of severe pain in the lower limbs. Read More

No Shinkei Geka 2018 Dec;46(12):1093-1101

Department of Neurosurgery, Yokohama Brain and Spine Center.

This 64-year-old woman had undergone endoscopic carpal tunnel release(ECTR)for right carpal tunnel syndrome 16 months earlier. Thereafter, she reported persistent dysesthesia in the thumb and index finger, developed burning pain in the middle and ring finger, paleness, coldness, and edema of the hand, a decreased range in hand motion, and a painful subcutaneous nodule just distal to the portal in the forearm. Based on physical, radiological, and electrophysiological studies, the diagnosis was incomplete carpal tunnel release associated with complex regional pain syndrome(CRPS). Read More

J Pain Res 2018 27;11:3025-3030. Epub 2018 Nov 27.

Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.

Purpose: Complex regional pain syndrome type 1 (CRPS I) is an intractable neuropathic pain syndrome. Chronic post-ischemia pain (CPIP) model is an animal model of CRPS I which is produced by ischemia-reperfusion (IR) injury of the hind limb. Dexmedetomidine (DEX) is a selective and potent α2 adrenergic receptor agonist with analgesic and protective effects following an IR injury. Read More

J Pain Res 2018 27;11:3019-3023. Epub 2018 Nov 27.

Department of Anesthesiology and Pain Medicine, Veterans Health Service Medical Center, Seoul, South Korea,

We successfully performed cervical spinal cord stimulator (SCS) surgery in a 27-year-old man with complex regional pain syndrome to control intractable pain. The SCS trial was performed twice to adjust the SCS coverage region. After permanent implantation surgery, the patient developed Horner's syndrome when the region near the C4 spinal dorsal root was stimulated. Read More

J Breath Res 2018 Dec 19. Epub 2018 Dec 19.

Center for Pain Medicine, Erasmus MC Pijnbehandelcentrum, Rotterdam, Zuid-Holland, NETHERLANDS.

Objective Complex Regional Pain Syndrome (CRPS) is a complication after surgery or trauma and is characterized by a continuing regional pain in a distal extremity. The pain is disproportionate in severity and duration in relation to the preceding trauma. Currently, the diagnosis is based on the patients' signs and symptoms. Read More

Oper Orthop Traumatol 2019 Feb 18;31(1):20-35. Epub 2018 Dec 18.

Sektion Sporttraumatologie und arthroskopische Chirurgie, BG Unfallklinik Tübingen, Schnarrenbergstr. 95, 72076, Tübingen, Deutschland.

Objective: Simultaneous arthroscopic reconstruction of the anterior and/or posterior cruciate ligament (ACL/PCL) using the GraftLink® system (Arthrex) to obtain stable treatment and good functional results. The transplant is protected by the safety belt like biomechanical GraftLink® principle, which is used to secure the intraoperatively obtained stability in the long term.

Indications: ACL, PCL, or combined cruciate ligament rupture, especially multiligament injuries. Read More

J Pain 2018 Dec 16. Epub 2018 Dec 16.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Event-Lab, Department of Clinical Psychology and Psychobiology, Universitat de Barcelona, Barcelona, Spain; ICREA, Barcelona, Spain; Departamento de Psicología Básica, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Modifying the visual aspect of a virtual arm that is felt as one's own using immersive virtual reality (VR) modifies pain threshold in healthy subjects, but does it modify pain ratings in chronic pain patients? Our aim was to investigate whether varying properties of a virtual arm co-located with the real arm modulated pain ratings in patients with chronic arm/hand pain because of complex regional pain syndrome (CRPS) type I (without nerve injury) or peripheral nerve injury (PNI). CRPS (n = 9) and PNI (n = 10) patients were immersed in VR and the virtual arm was shown at 4 transparency levels (transparency test) and 3 sizes (size test). We evaluated pain ratings throughout the conditions and assessed the virtual experience, finding that patients with chronic pain can achieve levels of ownership and agency over a virtual arm similar to healthy participants. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13272

Division of Pain Medicine, Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medicine, New York, New York.

Rationale: Continuous epidural infusion of local anesthetic may be an alternative to sympathetic blocks in refractory cases of complex regional pain syndrome (CRPS). Spinal epidural abscess (SEA) is a well-known complication associated with this technique, especially in patients with immune deficiencies. We herewith report a cervical SEA associated with an epidural catheter in a woman with CRPS and selective IgG3 subclass deficiency. Read More

Neurotherapeutics 2019 Jan;16(1):9-25

Division of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Pain is a frequent cause of physician visits. Many physicians find these patients challenging because they often have complicated histories, emotional comorbidities, confusing examinations, difficult problems to fix, and the possibility of factitious complaints for attention or narcotic pain medications. As a result, many patients are lumped into the category of chronic, centralized pain and relegated to pain management. Read More

Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1847. Epub 2018 Oct 16.

Elite Plastic Surgery, Phoenix, Arizona.

Background: Complex regional pain syndromes (CRPS) is a disease that is poorly understood. It is a chronic pain syndrome characterized by sympathetic disruptions as well as CNS sensitization. Botulinum Toxin-A has been shown to have efficacy in Raynaud's as well as other neuropathic pain disorders. Read More

J Pain Res 2018 13;11:2859-2866. Epub 2018 Nov 13.

Sannoh Orthopedic Clinic, Pain Clinic and Rehabilitation for Musculoskeletal Disorders, Sannoh Hospital, Chiba, Japan,

Background: Complex regional pain syndrome type I (CRPS I) in children is a serious condition disrupting the family and school life of patients with the condition after it fully develops. It has been emphasized that early diagnosis is closely associated with earlier reduction of pain leading to preferable outcomes.

Objectives: To report a case of acute CRPS I in a boy who was found to develop this condition by a routine visual analog scale (VAS) pain monitoring and who recovered from CRPS I at an early phase by prompt pharmacological, physical, and educational therapies. Read More

Neuroreport 2019 01;30(2):108-112

Emotional Information and Communication Technology Association, Seoul, Republic of Korea.

The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inositol (ml), glutamine (Gln), glycerophosphocholine (GPC), glutathione (GSH), and alanine (Ala) relative to total creatine (tCr) levels, including creatine and phosphocreatine, were determined in the right and left thalamus and insula in 12 patients with CRPS compared with 11 healthy controls using magnetic resonance spectroscopy. Levels of NAAG/tCr and Ala/tCr were higher in patients with CRPS than in controls in the left thalamus. Read More

Physiother Theory Pract 2018 Nov 30:1-13. Epub 2018 Nov 30.

d Phileo Health , Altoona , WI , USA.

Background: Chronic Regional Pain Syndrome (CRPS) is a condition that physical therapists may encounter in an outpatient orthopedic setting. In physical therapy (PT) treatment of CRPS addresses pain and the changes observed in the brain through the use of graded motor imagery (GMI).

Case Description: A 57-year-old female presented to an outpatient PT clinic with CRPS type 1. Read More

Immunol Res 2018 Nov 27. Epub 2018 Nov 27.

Rheumatology Department, National Institute of Cardiology, Mexico City, Mexico.

This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. Read More

Front Biosci (Landmark Ed) 2019 01 1;24:48-95. Epub 2019 Jan 1.

Berlin Cures GmbH Berlin, Knesebeckstrasse 59-61, 10719 Berlin, Germany,

In the 1970s, autoantibodies directed against G-protein-coupled receptors (GPCR, GPCR-AAB) were discovered. After receptor binding, GPCR-AAB trigger uncontrolled receptor mediated signal cascades, thus producing pathologies. Diseases associated with such functionally active autoantibody type (functional autoantibodies) can be called "functional autoantibody diseases". Read More

J Bone Miner Metab 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, University Medical Centre Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this study was to assess trabecular and cortical bone microstructure in patients with CRPS of the distal tibiae. Read More

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:3782-3787

Working towards improved neuromyoelectric control of dexterous prosthetic hands, we explored how differences in training paradigms affect the subsequent online performance of two different motor-decode algorithms. Participants included two intact subjects and one participant who had undergone a recent transradial amputation after complex regional pain syndrome (CRPS) and multi-year disuse of the affected hand. During algorithm training sessions, participants actively mimicked hand movements appearing on a computer monitor. Read More