116,724 results match your criteria Complex Partial Seizures


Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

Cell Mol Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

The Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Str, Kiev, 01030, Ukraine.

Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10571-019-00676-6DOI Listing
April 2019
1 Read

Reversible uraemic encephalopathy.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Neurology, All India Institute of Medical Sciences, New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228261DOI Listing

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019

P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.

Brain Res Bull 2019 Apr 18. Epub 2019 Apr 18.

School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China. Electronic address:

Epilepsy is accompanied by angiogenesis and blood-brain barrier (BBB) disruption. The transforming growth factor-β1 (TGF-β1)/phosphorylated small mothers against decapentaplegic 2 and 3 (pSmad2/3)/vascular endothelial growth factor (VEGF) pathway, activated by thrombospondin-1 (TSP-1), which is further regulated by Y type P2 purinergic receptor activity, may participate in angiogenesis. We sought to investigate the relationship between the P2R/TSP-1/TGF-β1/pSmad2/3/VEGF pathway, angiogenesis, and BBB damage in a kainic acid (KA) model of acute generalized seizure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.04.004DOI Listing

Tuberous Sclerosis Complex Genotypes and Developmental Phenotype.

Pediatr Neurol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Division of Medical Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Children with tuberous sclerosis complex (TSC), caused by pathogenic variants in TSC1/TSC2, are at risk for intellectual disability. TSC2 pathogenic variants appear to increase the risk, compared with TSC1. However, the effect of TSC2 pathogenic variants on early and specific domains of development hasn't been studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.003DOI Listing

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Lancet 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Electronic address:

Background: Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus.

Methods: This open-label, randomised clinical trial was undertaken at 30 UK emergency departments at secondary and tertiary care centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(19)30724-XDOI Listing

Anterior cingulate cortex involvement in non-paraneoplastic limbic encephalitis.

Brain Dev 2019 Apr 17. Epub 2019 Apr 17.

Department of Pediatrics, Asahi General Hospital, Chiba, Japan.

Background: Non-paraneoplastic limbic encephalitis is characterized by attention deficit, loss of emotion control, and impaired memory. Viral infection can cause acute encephalitis in children, occasionally exhibiting clinical features of limbic dysfunction. However, how viral infection affects the limbic system remains to be elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2019.04.006DOI Listing

Response to letter "Bias in determining factors associated with early seizures after surgery of unruptured intracranial aneurysms."

Clin Neurol Neurosurg 2019 Apr 12;181:67. Epub 2019 Apr 12.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03038467193010
Publisher Site
http://dx.doi.org/10.1016/j.clineuro.2019.04.006DOI Listing
April 2019
1 Read

Levetiracetam-induced a new seizure type in a girl with a novel SV2A gene mutation.

Clin Neurol Neurosurg 2019 Mar 28;181:64-66. Epub 2019 Mar 28.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; The Beijing Key Laboratory of Neuromodulation, Beijing 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China; Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:

The target brain binding site of levetiracetam (LEV) is synaptic vesicle glycoprotein 2A (SV2A). Up to now, only a homozygous pathogenic SV2A gene mutation was reported in human. We now report a novel heterozygous pathogenic SV2A gene mutation both in a girl and her mother result in epilepsy and poor response to LEV. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03038467193008
Publisher Site
http://dx.doi.org/10.1016/j.clineuro.2019.03.020DOI Listing
March 2019
1 Read

Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders.

Seizure 2019 Mar 19;69:99-104. Epub 2019 Mar 19.

PEDEGO Research Unit, University of Oulu, Oulu, Finland; Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Division of Pediatric Neurology, Oulu University Hospital, Oulu, Finland.

Purpose: Next-generation sequencing (NGS) has made genetic testing of patients with epileptic encephalopathies easier - novel variants are discovered and new phenotypes described. Variants in the same gene - even the same variant - can cause different types of epilepsy and neurodevelopmental disorders. Our aim was to identify the genetic causes of epileptic encephalopathies in paediatric patients with complex phenotypes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311173083
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.03.010DOI Listing
March 2019
1 Read

Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany.

Seizure 2019 Mar 29;69:92-98. Epub 2019 Mar 29.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg (Lahn), Germany; Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Electronic address:

Purpose: To identify factors correlating with poorer quality of life (QoL) in children and adolescents with epilepsy and regarding QoL and depression of their caregivers in Germany.

Method: A cross-sectional multicenter study on QoL and depression was performed in two representative German states (Hessen and Schleswig-Holstein). Variance analysis, linear regression, and bivariate correlation were used to identify correlating factors for poorer QoL and symptoms of depression. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183052
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.03.016DOI Listing
March 2019
1 Read

Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: involvement of cholinergic, nitrergic and pro-oxidant mechanisms.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil; Pharmacy Department, Faculty of Dentistry, Nursing and Pharmacy, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address:

Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated with sildenafil use. Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.04.008DOI Listing

Postvaccination Febrile Seizure Severity and Outcome.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, Australia.

Background: Febrile seizures (FSs) are a common pediatric condition caused by a sudden rise in temperature, affecting 3% to 5% of children aged ≤6 years. Although vaccination can cause FSs, little is known on whether FSs occurring in the time soon after vaccination (vaccine-proximate febrile seizures [VP-FSs] differ clinically from non-vaccine-proximate febrile seizures [NVP-FSs]). We compared the clinical profile and outcomes of VP-FS to NVP-FS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2018-2120DOI Listing
April 2019
2 Reads

Deep learning only by normal brain PET identify unheralded brain anomalies.

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea. Electronic address:

Background: Recent deep learning models have shown remarkable accuracy for the diagnostic classification. However, they have limitations in clinical application due to the gap between the training cohorts and real-world data. We aimed to develop a model trained only by normal brain PET data with an unsupervised manner to identify an abnormality in various disorders as imaging data of the clinical routine. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23523964193026
Publisher Site
http://dx.doi.org/10.1016/j.ebiom.2019.04.022DOI Listing
April 2019
1 Read

Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
1 Read

Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice.

Pharmacol Rep 2019 Feb 8;71(3):466-472. Epub 2019 Feb 8.

Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.

Background: β-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic system activity may modify epilepsy course, the aim of the present study was to examine the effect of salbutamol (SALB), one of the most commonly used β-adrenergic receptor agonist on the anticonvulsant potency of four classical antiepileptic drugs (AEDs): valproate (VPA), carbamazepine (CBZ), phenytoin (DPH) and phenobarbital (PB) in mice subjected to the maximal electroshock (MES)-induced seizures.

Methods: Seizures were caused by a current delivered through ear-clip electrodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.02.003DOI Listing
February 2019

Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.

Epilepsy Res 2019 Apr 4;154:1-7. Epub 2019 Apr 4.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. Electronic address:

Background: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous recurrent seizures and improve behavioral outcomes for rodents with TLE. However, the exact underlying mechanism for inhibition of TLE via ultrasound stimulation remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.04.002DOI Listing

The clinical presentation caused by truncating CHD8 variants.

Clin Genet 2019 Apr 18. Epub 2019 Apr 18.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, United Kingdom.

Variants in the chromodomain helicase DNA-binding protein 8 (CHD8) have been associated with intellectual disability (ID), autism spectrum disorders (ASD) and overgrowth and CHD8 is one of the causative genes for OGID (overgrowth and ID). We investigated 25 individuals with CHD8 protein truncating variants (PTVs), including 10 previously unreported patients and found a male to female ratio of 2.7:1 (19:7) and a pattern of common features: macrocephaly (62. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cge.13554
Publisher Site
http://dx.doi.org/10.1111/cge.13554DOI Listing
April 2019
1 Read

S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish.

Front Pharmacol 2019 2;10:122. Epub 2019 Apr 2.

Institute of Plant Biology, TU Braunschweig, Braunschweig, Germany.

Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of ionotropic glutamatergic receptors. Overstimulation leads to seizures, severe brain damage, and early childhood death. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fphar.2019.00122
Publisher Site
http://dx.doi.org/10.3389/fphar.2019.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454129PMC
April 2019
1 Read

Low-Intensity Pulsed Ultrasound Stimulation Modulates the Nonlinear Dynamics of Local Field Potentials in Temporal Lobe Epilepsy.

Front Neurosci 2019 2;13:287. Epub 2019 Apr 2.

Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China.

Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit seizures associated with temporal lobe epilepsy (TLE), which is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. Electroencephalography (EEG) signal analysis is an important method for studying epilepsy. The nonlinear dynamics of epileptic EEG signals can be used as biomarkers for the prediction and diagnosis of epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454000PMC

The Impact of Affective State on Quality of Life in Focal Epilepsy in Turkey.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):267-272

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Context: Seizures and accompanying situations including social, medical, and psychiatric problems threaten the quality of life (QOL) in patients with epilepsy. The World Health Organization defines health is a state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity.

Aims: This study examines the prevalence of both depression and anxiety symptoms and also impact of the affective state on QOL in patients with focal epilepsy in Turkey. Read More

View Article

Download full-text PDF

Source
http://www.ruralneuropractice.com/text.asp?2019/10/2/267/254
Publisher Site
http://dx.doi.org/10.4103/jnrp.jnrp_324_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454954PMC
April 2019
1 Read

Impact of Etiology on Efficacy of Oral Triclofos in Recording Pediatric Electroencephalography: A Tertiary Care Center Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):234-237

Department of Neurology, Niloufer Children's Hospital, Hyderabad, Telangana, India.

Background And Objectives: Oral triclofos is a frequently used sedative in pediatric age to record sleep Electroencephalography (EEG). This study is aimed to assess efficacy, safety profile, need for second dose, and rescheduling of oral triclofos in relation to etiology.

Materials And Methods: This is a retrospective study done enrolling all children aged 6 months to 5 years referred for EEG over 1 year. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jnrp.jnrp_280_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454965PMC

Long-Term Surface Electrode Impedance Recordings Associated with Gliosis for a Closed-Loop Neurostimulation Device.

Ann Neurosci 2018 Dec 14;25(4):289-298. Epub 2019 Jan 14.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: Closed-loop neurostimulation is a novel alternative therapy for medically intractable focal epilepsy for patients who are not candidates for surgical resection of a seizure focus. Electrodes for this system can be implanted either within the brain parenchyma or in the subdural space. The electrodes then serve the dual role of detecting seizures and delivering an electrical signal aimed at aborting seizure activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000481805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470334PMC
December 2018

Prevalence, Demographic Profile, and Psychological Aspects of Epilepsy in North-Western India: A Community-Based Observational Study.

Ann Neurosci 2018 Dec 12;25(4):177-186. Epub 2018 Jun 12.

Professor Preventive and Social Medicine, SMS Medical College, Jaipur, India.

Aims: This study was undertaken to determine the prevalence of active epilepsy, assess the sociodemographic profile, and psychological aspects of epilepsy in the Jaipur district of Rajasthan, India.

Methods: We conducted a community-based, cross-sectional observational study covering both rural ( = 165,660) and urban ( = 179,142) populations of Jaipur district using a house-to-house survey. An adapted, pre-designed World Health Organization screening questionnaire was used to identify the cases. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/487072
Publisher Site
http://dx.doi.org/10.1159/000487072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470329PMC
December 2018
1 Read

Congenital biotinidase deficiency - MRI findings in two cases.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):99-103

Consultant Radiologist, Vikas Diagnostics, Kanpur, Uttar Pradesh, India.

Congenital biotinidase deficiency is a rare inborn error of metabolism that most commonly presents in infantile age group. Diffusion changes on magnetic resonance imaging (MRI) are sparsely described in the literature. We are presenting diffusion-weighted MRI findings in two confirmed cases of congenital biotinidase deficiency in infantile age group with review of literature. Read More

View Article

Download full-text PDF

Source
http://www.ijri.org/text.asp?2019/29/1/99/255223
Publisher Site
http://dx.doi.org/10.4103/ijri.IJRI_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467045PMC
April 2019
1 Read

Retrospective Study of Patients with Hyperphenylalaninemia- Experience from a Tertiary Care Center in Pakistan.

J Pak Med Assoc 2019 Apr;69(4):509-513

Department of Paediatrics and Child Health, Aga Khan University, Karachi.

Objective: To assess the clinical and biochemical features as well as outcome of hyperphenylalaninemia patients.

Methods: The descriptive retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from January 2013 to February 2017 of plasma amino acid analysed at the Biochemical Genetic Laboratory of patients with phenylalanine levels >120 umol/L. Medical charts of patients registered with the Metabolic Clinics were reviewed, while outside referrals were contacted by telephone to collect data on a pre-structured questionnaire. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

The neurological syndromes associated with glutamic acid decarboxylase antibodies.

J Autoimmun 2019 Apr 15. Epub 2019 Apr 15.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; University of Guanajuato, Mexico. Electronic address:

A number of neurological syndromes have been described in patients with positive serum antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting step in the synthesis of GABA (γ-aminobutyric acid). These disorders include: classical stiff-person syndrome and variants, cerebellar ataxia, limbic and extra-limbic encephalitis, nystagmus/oculomotor dysfunction, drug-resistant epilepsy, paraneoplastic stiff-person syndrome and progressive encephalopathy with rigidity and myoclonus (PERM), the latter two are mainly related to amphiphysin and the glycine receptor Abs respectively; but patients may also have positive GAD-Abs. Although observations are consistent with an autoimmune response in these patients and there is evidence of GABAergic dysfunction in some cases; the pathogenic role of GAD-Abs in the nervous system has not been clarified and it is a matter of debate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.04.007DOI Listing
April 2019
1 Read

Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

Brain Dev 2019 Apr 15. Epub 2019 Apr 15.

Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Hypophosphatasia (HPP) is a rare disorder caused by low serum tissue non-specific alkaline phosphatase (ALP) activity due to hypomorphic mutations in the ALPL gene. HPP is characterized by defective bone mineralization. It frequently accompanies pyridoxine-responsive seizures. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604183059
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.03.015DOI Listing
April 2019
1 Read

Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
Publisher Site
http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
2 Reads

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing
March 2019
1 Read

Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183065
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing
April 2019
2 Reads

Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance.

Neurobiol Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

The interplay between excitatory and inhibitory circuits underlies the brain's processes and their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy. In patients with Alzheimer's disease (AD), an elevated occurrence of seizures has been observed in both sporadic and familial forms of the condition. Although seizure activity in AD has been mainly viewed as a result of neuronal cell loss and considered to occur in later stages, it is now becoming increasingly clear that aberrant neuronal activity may be more common in patients at earlier stages than previously thought and may trigger and contribute significantly to cognitive defects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.04.010DOI Listing
April 2019
3 Reads

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

View Article

Download full-text PDF

Source
April 2019
2 Reads

[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

View Article

Download full-text PDF

Source
April 2019
3 Reads

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Sci Rep 2019 Apr 17;9(1):6210. Epub 2019 Apr 17.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b and Scn1a mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA-evoked currents compared to wildtype in the third postnatal week. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-42191-0
Publisher Site
http://dx.doi.org/10.1038/s41598-019-42191-0DOI Listing
April 2019
2 Reads

Intracellular Peptides in Cell Biology and Pharmacology.

Biomolecules 2019 Apr 16;9(4). Epub 2019 Apr 16.

Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil.

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2218-273X/9/4/150
Publisher Site
http://dx.doi.org/10.3390/biom9040150DOI Listing
April 2019
2 Reads

QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis.

PLoS One 2019 17;14(4):e0215162. Epub 2019 Apr 17.

University Children's Hospital, Division of Child Neurology and Metabolic Diseases, Heidelberg, Germany.

Dihydropteridine reductase (QDPR) catalyzes the recycling of tetrahydrobiopterin (BH4), a cofactor in dopamine, serotonin, and phenylalanine metabolism. QDPR-deficient patients develop neurological symptoms including hypokinesia, truncal hypotonia, intellectual disability and seizures. The underlying pathomechanisms are poorly understood. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215162PLOS
April 2019
1 Read

Defining patterns of care in the management of patients with brain metastases in a large oncology centre: A single-centre retrospective audit of 236 cases.

Eur J Cancer Care (Engl) 2019 Apr 16:e13059. Epub 2019 Apr 16.

Department of Oncology and Radiotherapy, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aims: The role of selected treatments for brain metastases (BM) is well documented; however, the prevalence of these is not. We report on the patterns of care in the management of BM in a large oncology centre.

Materials And Methods: We retrospectively audited 236 cases of newly diagnosed BM from January 2016 to December 2017 by looking at 2 years of radiology reports and gathered data on primary site, survival, treatment received, palliative care input and brain metastases-related admissions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ecc.13059DOI Listing
April 2019
1 Read

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
2 Reads

as a cause of acute CNS infection in an immune-competent girl undergoing repeated VP shunt surgeries.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt revision surgeries. Eventually was isolated and the patient improved after specific treatment. is a rapidly growing, non-tuberculous mycobacterium (NTM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226900DOI Listing
April 2019
1 Read

Drug-drug interactions between antiepileptics and cannabinoids.

Expert Opin Drug Metab Toxicol 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Pathophysiology , Medical University of Lublin , Lublin , Poland.

Introduction: About 40% of patients with epilepsy are associated with drug-resistant seizures, therefore there has been a continuous search for novel treatment approaches. In experimental studies, natural and synthetic cannabimimetic compounds alone or combined with antiepileptic drugs (AEDs) have been extensively studied and cannabidiol, a naturally occurring compound, has been involved in a number of clinical trials. Areas covered: The authors have performed a literature search (PubMed database up to December 2018) for studies evaluating interactions between AEDs and cannabinoid receptor ligands in experimental models of seizures. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
Publisher Site
http://dx.doi.org/10.1080/17425255.2019.1605355DOI Listing
April 2019
2 Reads

[Conditioning psychosis - A new type of epileptic psychosis? A case report on a bidirectional connection between epilepsy and psychosis.]

Fortschr Neurol Psychiatr 2019 Apr 16. Epub 2019 Apr 16.

Introduction: Epilepsy and psychosis are not only closely related by clinical phenomena but presumably by causal factors, too. There is evidence that long-standing epileptic seizures can induce chronic psychosis. Whether chronic psychosis can cause epilepsy remains to be further investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0832-8557DOI Listing
April 2019
1 Read

Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress.

Physiol Behav 2019 Apr 13;206:200-205. Epub 2019 Apr 13.

Department of Pharmacology, Jordan University of Science and Technology, Irbid, Jordan.

There is increasing evidence that oxidative stress is a causal factor in different neurodegenerative disorders such as Alzheimer's disease and epilepsy. High-fat diet (HFD) has been shown to induce oxidative stress and neuronal damage that may increase susceptibility to seizures. The present study was undertaken to investigate the relationships between vitamin E, a potent antioxidant, HFD, and chemically induced seizures, using the PTZ seizure model in rats. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00319384183121
Publisher Site
http://dx.doi.org/10.1016/j.physbeh.2019.04.011DOI Listing
April 2019
4 Reads

Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 12. Epub 2019 Apr 12.

Introduction: Current truncating circuit designs used in some controllable pulse width transcranial magnetic stimulation systems can be adapted for use with the peripheral nervous system. Such a scaled-down stimulator produces neuromuscular activation using less stimulus energy than described in previous reports of sciatic nerve stimulation.

Methods: To evaluate the energy reductions possible with current truncation, we performed six in vivoexperiments in rats where the magnetic stimulating coil abutted the sciatic nerve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TNSRE.2019.2911054DOI Listing
April 2019
1 Read

Left Ventricular Assist Device Artifact in EEG.

Neurodiagn J 2019 Apr 16:1-9. Epub 2019 Apr 16.

b Department of Anesthesiology University of Florida College of Medicine , Gainesville , Florida.

Left ventricular assist devices are increasingly used as therapy for patients with severe congestive heart failure. These patients typically receive care in the intensive care unit when EEG monitoring is necessary. Identification of artifacts created by these devices is important for accurate EEG diagnosis, thus avoiding unnecessary therapies that may result in complications or require intubation of the patient. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21646821.2019.1
Publisher Site
http://dx.doi.org/10.1080/21646821.2019.1599649DOI Listing
April 2019
3 Reads

[Familial hypomagnesaemia with secondary hypocalcaemia as a cause of seizures in children].

Ugeskr Laeger 2019 Apr;181(15)

This case report presents a three-month-old girl, previously healthy, who was admitted to the hospital due to a cyanotic episode during breastfeeding. The episode was initially interpreted as aspiration. She had recurrent generalised seizures, and blood tests revealed hypomagnesaemia and hypocalcaemia. Read More

View Article

Download full-text PDF

Source
April 2019
3 Reads

[Fangji Dihuang Decoction formula syndrome and Fengyin Decoction formula syndrome:application in stroke and mental disorders].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):602-607

Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.

Fangji Dihuang Decoction and Fengyin Decoction, which were firstly recorded in Synopsis of the Golden Chamber, could be used to treat stroke. However, both of these two decoctions are used infrequently. There is a clear pathogenesis of modern pathophysiology behind Fangji Dihuang Decoction syndrome and Fengyin Decoction syndrome, which can be interpreted by modern language of science. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.004DOI Listing
February 2019
1 Read