207,991 results match your criteria Complementary Therapies in Clinical Practice [Journal]


Methadone therapy modulate the dendritic cells of heroin addicts.

Int Immunopharmacol 2018 Dec 3;66:330-335. Epub 2018 Dec 3.

Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran; Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Electronic address:

Evidence from various studies suggests that narcotics abuse may exert adverse immunomodulatory effects on immune responses. The aim of this research was to understand the effects of detoxification with methadone on the percentage of dendritic cells (DCs) and expression of its markers in heroin addicts. In this study, myeloid DCs (CD11c) and plasmacytoid DCs (CD123) were examined in two groups. Read More

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December 2018
2 Reads

Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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December 2018

An update and systematic review on the treatment of primary dysmenorrhea.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Nursing Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.

Objectives: Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. Read More

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December 2018
1 Read

BIOINFORMATIC ANALYSIS OF DOSE- AND TIME-DEPENDENT miRNome RESPONSES.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Rome, Italy.

The advent of new 'omics' techniques determined a massive boost in the measurement of the whole spectra of molecules within cells, favoring promising new radiobiological studies at low doses. The main aim of this work was to assess the radiation-induced perturbations of miRNA profiles and their temporal dynamics. Human Umbilical Vein Endothelial Cells were irradiated with low doses of γ-rays. Read More

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December 2018
2 Reads

Posttranscriptional spin labeling of RNA by tetrazine-based cycloaddition.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Life & Medical Sciences Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

The site-specific introduction of spin labels into RNA for distance measurements by EPR gives insight into its solution structure. We here present a method for spin labeling of in vitro transcribed RNA. Distance distributions between two nitroxide spin labels are determined by PELDOR in a self-complementary RNA duplex. Read More

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December 2018

Laparoscopic Multiple Parenchyma-sparing Concomitant Liver Resections for Colorectal Liver Metastases.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Intervention Centre.

Background: Parenchyma-sparing concept in liver surgery has received a new incitement with the introduction of laparoscopic techniques. Multiple concomitant liver resections are a major component in the parenchyma-sparing concept.

Materials And Methods: In total, 689 patients underwent laparoscopic liver resection for colorectal liver metastases from August 1998 to 2017, and 171 patients were eligible for this study. Read More

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December 2018

Synthesis of urban CO emission estimates from multiple methods from the Indianapolis Flux Project (INFLUX).

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

Urban areas contribute approximately three-quarters of fossil fuel derived CO emissions, and many cities have enacted emissions mitigation plans. Evaluation of the effectiveness of mitigation efforts will require measurement of both the emission rate and its change over space and time. The relative performance of different emission estimation methods is a critical requirement to support mitigation efforts. Read More

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December 2018
5 Reads

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires. Argentina.

Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Read More

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December 2018
1 Read

Cranberry consumption against urinary tract infections: Clinical state-of-the-art and future perspectives.

Curr Pharm Biotechnol 2018 Dec 5. Epub 2018 Dec 5.

Department of Food Science & Nutrition, School of Environment, University of the Aegean, Lemnos. Greece.

Introduction: Urinary tract infections (UTIs) represent a common and costly public health issue. The bacterium Escherichia coli is mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have extensively been studied in order to understand the molecular mechanisms of action of its bioactive components and their clinical benefits against UTIs. Read More

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December 2018

Next-generation PNA chimeras exhibit high affinity and potent gene silencing.

Biochemistry 2018 Dec 6. Epub 2018 Dec 6.

We present a new design of mixed-backbone antisense oligonucleotides (ASOs) containing both DNA and peptide nucleic acid (PNA). Previous generations of PNA-DNA chimeras showed low binding affinity, reducing their potential as therapeutics. The addition of a 5'-wing of locked nucleic acid as well as the combination of modified nucleotide and PNA monomer at the junction between PNA and DNA gave high affinity to the chimeras. Read More

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December 2018

Operando CatalysisReveals the Superior Cracking Activity and Stability of Hierarchical ZSM-5 for the Cracking of LDPE.

ChemSusChem 2018 Dec 5. Epub 2018 Dec 5.

Jagiellonian University in Karków, Faculty of Chemistry, 3 Ingarden Street, 30-060, Kraków, POLAND.

In this communication, a new theoretical and practical framework through Operando Catalysis to study the zeolite catalytic cracking of the low-density polyethylene as model reaction, under reaction conditions is provided. Results show that a microporous ZSM-5 gives rise to less cracking products. Hierarchical ZSM-5 zeolites are more cracking active, rendering more C2-C5 hydrocarbons, with a delayed deactivation due to the secondary porosity. Read More

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December 2018

Response shift effects of quality of life assessments in breast cancer survivors.

Eur J Cancer Care (Engl) 2018 Dec 6:e12979. Epub 2018 Dec 6.

Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.

Measurements of quality of life (QoL) can be distorted by respondents adapting to new situations between measurement points and consequently having a changed frame of reference. To investigate this bias in breast cancer survivors, we compare their QoL with that of the general population and use two complementary methods for detecting this bias. Breast cancer survivors (n = 308, response rate: 91%) were tested with the QoL questionnaire European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Read More

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December 2018
1 Read

Medium-Range Narratives as a Complementary Tool to Principle-Based Prioritization in Sweden: Test Case "ADHD".

J Bioeth Inq 2018 Dec 5. Epub 2018 Dec 5.

Institute for Ethics, History and Philosophy of Medicine, University of Muenster, Muenster, Germany.

In this paper, for the benefit of reflection processes in clinical and in local, regional, and national priority-setting, we aim to develop an ethical theoretical framework that includes both ethical principles and medium-range narratives. We present our suggestion in the particular case of having to choose between treatment interventions for attention deficit hyperactivity disorder (ADHD) and treatment interventions for other conditions or diseases, under circumstances of scarcity. In order to arrive at our model, we compare two distinct ethical approaches: a generalist (principles) approach and a particularist (narratives) approach. Read More

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December 2018

Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression.

BMJ Open Ophthalmol 2018 25;3(1):e000195. Epub 2018 Oct 25.

Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway.

Objective: To estimate the macular ganglion cell complex (GCC) asymmetry in patients with suprasellar tumours, to compare its diagnostic performance to the nasal GCC thickness and visual field (VF) and to investigate how the parameters correlate with magnetic resonance imaging (MRI) findings.

Methods And Analysis: Cross-sectional study of patients with suprasellar tumours affecting the optic chiasm. Macular optical coherence tomography (OCT) scans were evaluated for nasal GCC sector thinning and loss of normal GCC asymmetry between corresponding nasal-temporal sectors. Read More

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October 2018
1 Read

Data concerning secondary structure and alpha-glucans-binding capacity of the CBM26.

Data Brief 2018 Dec 14;21:1944-1949. Epub 2018 Nov 14.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), A.P. 70228, Ciudad Universitaria, Ciudad de México 04510, México.

Carbohydrate-binding modules (CBMs) are auxiliary domains into glycoside-hydrolases that allow the interaction between the insoluble substrate and the solubilized enzyme, through hydrophobic, CH-π interactions and hydrogen bonds. Here, we present the data article related to the interaction of one CBM26 and some mutated proteins with soluble α-glucans determined by enzyme-linked carbohydrate-binding assay, isothermal titration calorimetry (ITC), and affinity gel electrophoresis (AGE). The data of the behavior of proteins in presence and absence of substrate analyzed by circular dichroism CD and thermofluor are also presented. Read More

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December 2018

Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety.

Acta Pharmacol Sin 2018 Dec 5. Epub 2018 Dec 5.

Centre for Human Drug Research, Leiden, 2333 CL, The Netherlands.

Anxiety disorders arise from disruptions among the highly interconnected circuits that normally serve to process the streams of potentially threatening stimuli. The resulting imbalance among these circuits can cause a fundamental misinterpretation of neural sensory information as threatening and can lead to the inappropriate emotional and behavioral responses observed in anxiety disorders. There is considerable preclinical evidence that the GABAergic system, in general, and its α2- and/or α5-subunit-containing GABA(A) receptor subtypes, in particular, are involved in the pathophysiology of anxiety disorders. Read More

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December 2018

Novel and conventional approaches for the analysis of quantitative proteomic data are complementary towards the identification of seminal plasma alterations in infertile patients.

Mol Cell Proteomics 2018 Dec 5. Epub 2018 Dec 5.

Molecular Biology of Reproduction and Development, Human Genetics Unit, Faculty of Medicine, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, and Hospital Clinic, Spain

Our aim was to define seminal plasma proteome signatures of infertile patients categorized according to their seminal parameters using TMT-LC-MS/MS. To that extent, quantitative proteomic data was analyzed following two complementary strategies: (i) the conventional approach based on standard statistical analyses of relative protein quantification values; and (ii) a novel strategy focused on establishing stable-protein pairs. By conventional analyses, the abundance of some seminal plasma proteins was found to be positively correlated with sperm concentration. Read More

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December 2018

Predictors of stunting with particular focus on complementary feeding practices: A cross-sectional study in the northern province of Rwanda.

Nutrition 2018 Sep 6;60:11-18. Epub 2018 Sep 6.

Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, the Netherlands.

Objectives: The aim of this study was to review the factors associated with stunting in the northern province of Rwanda by assessing anthropometric status, dietary intake, and overall complementary feeding practices.

Methods: This was a cross-sectional study with 138 children 5 to 30 mo of age. A structured questionnaire was used to collect information on sociodemographic characteristics of each mother and child and breastfeeding and complementary feeding practices. Read More

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September 2018

Inattentional deafness to auditory alarms: inter-individual differences, electrophysiological signature and single trial classification.

Behav Brain Res 2018 Nov 30. Epub 2018 Nov 30.

ISAE-SUPAERO, Université de Toulouse, France.

Inattentional deafness can have deleterious consequences in complex real-life situations (e.g. healthcare, aviation) leading to miss critical auditory signals. Read More

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November 2018

Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation.

Eur J Pharm Sci 2018 Nov 30. Epub 2018 Nov 30.

Novartis Institutes for BioMedical Research, East Hanover, NJ, USA.

Simultaneous blockade of angiotensin receptors and enhancement of natriuretic peptides (NP) by the first-in-class angiotensin receptor neprilysin (NEP) inhibitor sacubitril/valsartan constitutes an effective approach to treating heart failure. This study examined the effects of sacubitril/valsartan (225 and 675 mg/day) vs. placebo, sacubitril (360 mg/day), valsartan (900 mg/day), and benazepril (5 mg/day) on the dynamics of the renin-angiotensin-aldosterone system (RAAS) and the NP system in dogs. Read More

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November 2018

Air Pollution in the Asia-Pacific Region: A Joint APSR/ATS Perspective.

Am J Respir Crit Care Med 2018 Dec 3. Epub 2018 Dec 3.

The Prince Charles Hospital, Metro North Hospital and Health Service, Brisbane, Queensland, Australia.

Industrial and technological developments have led to major economic growth in the Asia Pacific, but an unintended consequence has been an increase in illness associated with air pollution. Given the complementary mandates of the Asian Pacific Society of Respirology and the American Thoracic Society, the organizations partnered to focus on the need for clean air. A task force was assembled with individuals who have expertise in the effects of air pollution or the development of professional society policy statements. Read More

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December 2018

Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study.

J Spinal Cord Med 2018 Dec 3:1-8. Epub 2018 Dec 3.

d Neurology Unit , Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.

Objective: Hereditary spastic paraplegia (HSP) represents a heterogeneous group of neurodegenerative diseases characterized by progressive spasticity and lower limb weakness. We assessed the effects of transcutaneous spinal direct current stimulation (tsDCS) in HSP.

Design: A double-blind, randomized, crossover and sham-controlled study. Read More

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December 2018

iHam & pyHam: visualizing and processing hierarchical orthologous groups.

Bioinformatics 2018 Dec 3. Epub 2018 Dec 3.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Summary: The evolutionary history of gene families can be complex due to duplications and losses. This complexity is compounded by the large number of genomes simultaneously considered in contemporary comparative genomic analyses. As provided by several orthology databases, hierarchical orthologous groups (HOGs) are sets of genes that are inferred to have descended from a common ancestral gene within a species clade. Read More

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December 2018
2 Reads

Raman and infrared spectroscopy reveal that proliferating and quiescent human fibroblast cells age by biochemically similar but not identical processes.

PLoS One 2018 3;13(12):e0207380. Epub 2018 Dec 3.

Spectroscopy and Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.

Dermal fibroblast cells can adopt different cell states such as proliferation, quiescence, apoptosis or senescence, in order to ensure tissue homeostasis. Proliferating (dividing) cells pass through the phases of the cell cycle, while quiescent and senescent cells exist in a non-proliferating cell cycle-arrested state. However, the reversible quiescence state is in contrast to the irreversible senescence state. Read More

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December 2018

Alternating Diffusion Map Based Fusion of Multimodal Brain Connectivity Networks for IQ Prediction.

IEEE Trans Biomed Eng 2018 Nov 29. Epub 2018 Nov 29.

Objective: To explain individual differences in development, behavior, and cognition, most previous studies focused on projecting resting-state functional MRI (fMRI) based functional connectivity (FC) data into a low-dimensional space via linear dimensionality reduction techniques, followed by executing analysis operations. However, linear dimensionality analysis techniques may fail to capture nonlinearity of brain neuroactivity. Moreover, besides resting-state FC, FC based on task fMRI can be expected to provide complementary information. Read More

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November 2018

Deep Leaning Based Multi-Modal Fusion for Fast MR Reconstruction.

IEEE Trans Biomed Eng 2018 Nov 29. Epub 2018 Nov 29.

T1-weighted image (T1WI) and T2-weighted image (T2WI) are the two routinely acquired magnetic resonance (MR) modalities that can provide complementary information for clinical and research usages. However, the relatively long acquisition time makes the acquired image vulnerable to motion artifacts. To speed up the imaging process, various algorithms have been proposed to reconstruct high-quality images from under-sampled k-space data. Read More

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November 2018

Measuring the Social Impact of Nursing Research: An Insight into Altmetrics.

J Adv Nurs 2018 Dec 3. Epub 2018 Dec 3.

The University of Jordan Accreditation and Quality Assurance Center.

Aims: The objectives of this study were to (1) identify nursing journal articles that provoked the most online activity and discussion and (2) assess the association between these articles' altmetric scores and publication characteristics, citation counts; and publishing journals metrics.

Background: Altmetrics, or alternative metrics, have recently emerged as a complementary way of measuring the societal impact of research by assessing the public engagement with research output. To date, no studies have yet investigated the online attention regarding scientific papers published in the nursing field. Read More

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December 2018
2 Reads

Raw material quality assessment approaches comparison in pectin production.

Biotechnol Prog 2018 Dec 3. Epub 2018 Dec 3.

Process and Systems Engineering Centre (PROSYS), Department of Chemical and Biochemical Engineering, Technical University of Denmark, Søltofts Plads Building 229, DK-2800 Kgs. Lyngby, Denmark.

This article explores different opportunities to evaluate quality variation in raw materials from biological origin. Assessment of raw materials attributes is an important step in a bio-based production since fluctuations in quality are a major source of process disturbance. This can be due to a variety of biological, seasonal and supply scarcity reasons. Read More

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December 2018

Postforced eviction communities: The contribution of personal and environmental resources to the sense of belonging to the community.

J Community Psychol 2019 Jan 23;47(1):104-116. Epub 2018 Jul 23.

Bar Ilan University.

This article aims to examine the contribution of personal and environmental resources to the sense of belonging to the community among postforced eviction communities. The study included 140 participants who experienced forced eviction, and ranged in age from 20 to 79 years. Slightly more than half were women (52. Read More

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January 2019

Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue.

Obesity (Silver Spring) 2018 Dec 2. Epub 2018 Dec 2.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.

Objective: Naringenin, a citrus flavonoid, prevents diet-induced weight gain and improves glucose and lipid metabolism in rodents. There is evidence that naringenin activates brown fat and increases energy expenditure in mice, but little is known about its effects in humans. The goal of this study was to examine the effects of naringenin on energy expenditure in adipose tissue. Read More

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December 2018

Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD.

Aliment Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

Department of Medicine, NAFLD Research Center, University of California at San Diego, La Jolla, California.

Background: The fasting-state serum bile acid profile in nonalcoholic fatty liver disease (NAFLD) has been reported to differ when nonalcoholic steatohepatitis is compared to nonalcoholic fatty liver. However, there are few data comparing changes in NAFLD vs non-NAFLD, or whether the bile acid profile differs according to the degree of fibrosis.

Aim: To examine the serum bile acid profile across the entire spectrum of NAFLD. Read More

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December 2018
1 Read

Partitioning wild bee and hoverfly contributions to plant-pollinator network structure in fragmented habitats.

Ecology 2018 Dec 1. Epub 2018 Dec 1.

Department of Animal Ecology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.

The risk of ecosystem function degradation with biodiversity loss has emerged as a major scientific concern in recent years. Possible relationships between taxonomic diversity and magnitude and stability of ecosystem processes build upon species' functional characteristics, which determine both susceptibility to environmental change and contribution to ecosystem properties. The functional diversity within communities thus provides a potential buffer against environmental disturbance, especially for properties emerging from interactions among species. Read More

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December 2018

A miR-18a binding-site polymorphism in CDC42 3'UTR affects CDC42 mRNA expression in placentas and is associated with litter size in pigs.

Mamm Genome 2018 Dec 1. Epub 2018 Dec 1.

Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.

Increasing evidence suggests that miRNA binding-site polymorphism in the 3'-untranslated region (3'UTR) of a target gene could affect that gene's expression, and can be associated with a variety of complex traits. In this study, we find that miR-18a and cell division cycle 42 (CDC42) mRNA, whose expression was inversely correlated, are differentially expressed in porcine placentas during critical stages of placental development. rs55618224 (T>C), a SNP in the 3'UTR region of CDC42 that is perfectly complementary to the miR-18a seed could influence miR-18a-related regulation of CDC42 gene by altering their binding affinity. Read More

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December 2018

Probing the function of protein farnesyltransferase in Tripterygium wilfordii.

Plant Cell Rep 2018 Nov 30. Epub 2018 Nov 30.

School of Traditional Chinese Medicine, Capital Medical University, Beijing, 10069, China.

Key Message: We found two subunits FTase/GGTaseI-α and FTase-β formed a heterodimer to transfer a farnesyl group from FPP to protein N-dansyl-GCVLS, confirming they are responsible for protein farnesylation in planta. Tripterygium wilfordii is a medicinal plant with a broad spectrum of anti-inflammatory, immunosuppressive and anti-cancer activities. Recently, a number of studies have focused on investigating the biosynthetic pathways of its bioactive compounds, whereas little attention has been paid to the enzymes which play important roles in regulating diverse developmental processes of T. Read More

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November 2018

Fetal Body Imaging: When is MRI Indicated?

Authors:
Marie Cassart

J Belg Soc Radiol 2017 Nov 18;101(Suppl 1). Epub 2017 Nov 18.

Hôpitaux Iris et Iris Sud, BE.

Recent improvements in fetal therapies and perinatal care and the multidisciplinary involvement in fetal medicine have increased the demand for more accurate prenatal diagnosis. Fetal Magnetic Resonance Imaging (MRI) is a complementary imaging technique for the assessment of thoraco-abdominal anomalies for which Ultrasonography (US) is not conclusive. It is indicated in selected situations to precise the prognosis in diaphragmatic hernia, to characterise the nature and extension of a pulmonary malformation, to locate a bowel atresia or to better depict an abdominal cystic lesion or tumoural extension. Read More

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November 2017
2 Reads

Innovations in digital interventions for psychological trauma: harnessing advances in cognitive science.

Mhealth 2018 19;4:47. Epub 2018 Oct 19.

Centre for Children's Health Research, Institute of Health and Biomedical Innovation, and School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.

A range of digital psychological interventions have demonstrated a positive impact on trauma-related problems in controlled trials, but there is room for further improvements in their form, reach and impact. Most to date have been adaptions of established face-to-face treatments. In this paper, we highlight a complementary emerging route to their development, which draws on advances in cognitive science theory and research and applies them to clinical contexts. Read More

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October 2018

Tumor mutational burden in non-small cell lung cancer-the pathologist's point of view.

Transl Lung Cancer Res 2018 Dec;7(6):716-721

Department of pathology, Centre Jean Perrin, Clermont-Ferrand, France.

In non-small cell lung cancer (NSCLC), the pathologist has contributed to the development of personalized medicine from the determination of the right histological type to and molecular screening for targeted therapies. With the development of immunotherapies, pathologists intervene forefront with programmed death-ligand 1 (PD-L1) immunohistochemical testing, companion test for pembrolizumab monotherapy, first line and complementary test to the other programmed cell death-1 (PD-1) PD-L1 inhibitors. Recently, tumor mutational burden has emerged as a promising tool to evaluate sensitivity to immunotherapy (IO). Read More

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December 2018
1 Read

High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway.

Acta Pharm Sin B 2018 Oct 10;8(6):889-899. Epub 2018 Jul 10.

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.

Interferons (IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon (IFN-) and interferon (IFN-), act through a shared receptor complex (IFNAR) comprised of IFNAR1 and IFNAR2 subunits. Binding of type-I IFN to IFNAR1 will robustly activate Janus activated kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. Read More

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October 2018

Fostering the conduct of ethical and equitable research practices: the imperative for integrated knowledge translation in research conducted by and with indigenous community members.

Res Involv Engagem 2018 26;4:45. Epub 2018 Nov 26.

Innu Round Table, 7 Peenamin Drive, Sheshatshiu, Newfoundland and Labrador, Canada.

Plain English Summary: Integrated knowledge translation is a research approach in which researchers work as partners with the people for whom the research is meant to be of use. A partnered approach can support the use of Indigenous ways of knowing in health research that may then be used in health care. This is important as current health care models do not often support Indigenous values, ways of knowing, and care practices. Read More

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November 2018

DeepConPred2: An Improved Method for the Prediction of Protein Residue Contacts.

Comput Struct Biotechnol J 2018 10;16:503-510. Epub 2018 Nov 10.

MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Information of residue-residue contacts is essential for understanding the mechanism of protein folding, and has been successfully applied as special topological restraints to simplify the conformational sampling in de novo protein structure prediction. Prediction of protein residue contacts has experienced amazingly rapid progresses recently, with prediction accuracy approaching impressively high levels in the past two years. In this work, we introduce a second version of our residue contact predictor, DeepConPred2, which exhibits substantially improved performance and sufficiently reduced running time after model re-optimization and feature updates. Read More

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November 2018

Integration of stiff graphene and tough silk for the design and fabrication of versatile electronic materials.

Adv Funct Mater 2018 Feb 19;28(9). Epub 2017 Dec 19.

Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

The production of structural and functional materials with enhanced mechanical properties through the integration of soft and hard components is a common approach to Nature's materials design. However, directly mimicking these optimized design routes in the lab for practical applications remains challenging. For example, graphene and silk are two materials with complementary mechanical properties that feature ultrahigh stiffness and toughness, respectively. Read More

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February 2018

Effect of dietary additives on intestinal permeability in both and a human cell co-culture.

Dis Model Mech 2018 Nov 28;11(12). Epub 2018 Nov 28.

Department of Biological Sciences, Binghamton University, Binghamton, New York 13902, USA

Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing and food additive consumption. Additives, including sugar, metal oxide nanoparticles, surfactants and sodium chloride, have all been suggested to increase intestinal permeability. Read More

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November 2018

Disentangling topographic contributions to near-field scanning microwave microscopy images.

Ultramicroscopy 2018 Nov 12;197:53-64. Epub 2018 Nov 12.

National Institute of Standards and Technology, Boulder, CO 80305, USA.

We develop empirical models to predict the contribution of topographic variations in a sample to near-field scanning probe microwave microscopy (NSMM) images. In particular, we focus on |S| images of a thin Perovskite photovoltaic material and a GaN nanowire. The difference between the measured NSMM image and this prediction is our estimate of the contribution of material property variations to the measured image. Read More

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November 2018
1 Read

Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy.

J Proteomics 2018 Nov 29. Epub 2018 Nov 29.

Clinical Neuroproteomics Group, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain; IDISNA, Navarra Institute for Health Research, Pamplona, Spain; Proteored-ISCIII, Proteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain. Electronic address:

Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection remains poorly understood. Here, proteomics was applied to characterize the glioma metabolic disturbances soon after Delta-24-RGD internalization and late in infection. Read More

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November 2018

Dynamics of Cas10 Govern Discrimination between Self and Non-self in Type III CRISPR-Cas Immunity.

Mol Cell 2018 Nov 27. Epub 2018 Nov 27.

Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

Adaptive immune systems must accurately distinguish between self and non-self in order to defend against invading pathogens while avoiding autoimmunity. Type III CRISPR-Cas systems employ guide RNA to recognize complementary RNA targets, which triggers the degradation of both the invader's transcripts and their template DNA. These systems can broadly eliminate foreign targets with multiple mutations but circumvent damage to the host genome. Read More

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November 2018

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objective: The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation.

Methods: Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement.

Results: Thirty-two patients were included, with 571 endoscopic procedures. Read More

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November 2018
1 Read

Correcting errors in the BRCA1 warning system.

DNA Repair (Amst) 2018 Nov 22. Epub 2018 Nov 22.

Virgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA; Center for Structural Oncology, Pennsylvania State University, University Park, PA, 16802, USA. Electronic address:

Given its important role in human health and disease, remarkably little is known about the full-length three-dimensional (3D) molecular architecture of the breast cancer type 1 susceptibility protein (BRCA1), or its mechanisms to engage the tumor suppressor, TP53 (p53). Here, we show how a prevalent cancer-related mutation in the C-terminal region of the full-length protein, BRCA1, affects its structural properties, yet can be biochemically corrected to restore its functional capacity. As a downstream consequence of restoring the ubiquitin ligase activity of mutated BRCA1, the DNA repair response of p53 was enhanced in cellular extracts naturally deficient in BRCA1 protein expression. Read More

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November 2018

OUTRIDER: A Statistical Method for Detecting Aberrantly Expressed Genes in RNA Sequencing Data.

Am J Hum Genet 2018 Nov 21. Epub 2018 Nov 21.

Department of Informatics, Technical University of Munich, Boltzmannstr. 3, 85748 Garching, Germany; Quantitative Biosciences Munich, Gene Center, Department of Biochemistry, Ludwig-Maximilians Universität München, Feodor-Lynen-Str. 25, 81377 München, Germany. Electronic address:

RNA sequencing (RNA-seq) is gaining popularity as a complementary assay to genome sequencing for precisely identifying the molecular causes of rare disorders. A powerful approach is to identify aberrant gene expression levels as potential pathogenic events. However, existing methods for detecting aberrant read counts in RNA-seq data either lack assessments of statistical significance, so that establishing cutoffs is arbitrary, or rely on subjective manual corrections for confounders. Read More

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November 2018
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Determining the impact of culture on venous thromboembolism prevention in trauma patients: A Southwestern Surgical Congress Multicenter trial.

Am J Surg 2018 Nov 20. Epub 2018 Nov 20.

Scott & White Medical Center - Temple, TX, USA.

Introduction: Venous thromboembolism (VTE) remains one of the principal causes of morbidity and death in trauma patients that survive the first 24 h. Recent literature on VTE prevention focuses on choice of chemoprophylaxis, specifically unfractionated heparin (UFH) versus low molecular weight heparin (LMWH). This singular focus on a multifactorial process may be inadequate to fully understand the optimal approach to VTE prevention. Read More

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November 2018
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Invasive evaluation in children (SEEG vs subdural grids).

Seizure 2018 Nov 16. Epub 2018 Nov 16.

Service de neurochirurgie pédiatrique, Fondation Rothschild 25-29, rue Manin Paris Cedex 19, France.

Designed from the 60s to the 80s for adults, and despite the development of many new techniques, invasive explorations still have indications in children with focal drug-resistant epilepsy. The main types are stereoelectroencephalography (SEEG) and subdural explorations (SDE). They provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex, and the feasibility of performing a tailored surgical resection. Read More

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November 2018
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