188 results match your criteria Complement-Related Disorders


Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Front Immunol 2018 20;9:2664. Epub 2018 Nov 20.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. Read More

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November 2018
1 Read

Interpretation of Serological Complement Biomarkers in Disease.

Front Immunol 2018 24;9:2237. Epub 2018 Oct 24.

Rudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complement-related differences between patient groups and controls. Read More

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October 2018
3 Reads

Pathogenesis of Atypical Hemolytic Uremic Syndrome.

J Atheroscler Thromb 2018 Nov 2. Epub 2018 Nov 2.

Division of Nephrology and Endocrinology, the University of Tokyo Hospital.

Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP). A variety of genetic defects in complement-related factors or acquired autoantibodies to the complement regulators have been found in 50 to 60% of all cases. Read More

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November 2018
4 Reads

Complement-mediated renal diseases after kidney transplantation - current diagnostic and therapeutic options in and recurrent diseases.

World J Transplant 2018 Oct;8(6):203-219

Faculty of Health and Science, University of Liverpool, Institute of Learning and Teaching, School of Medicine, Liverpool L69 3GB, United Kingdom.

For decades, kidney diseases related to inappropriate complement activity, such as atypical hemolytic uremic syndrome and C3 glomerulopathy (a subtype of membranoproliferative glomerulonephritis), have mostly been complicated by worsened prognoses and rapid progression to end-stage renal failure. Alternative complement pathway dysregulation, whether congenital or acquired, is well-recognized as the main driver of the disease process in these patients. The list of triggers include: surgery, infection, immunologic factors, pregnancy and medications. Read More

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October 2018
5 Reads

Identification of complement-related host genetic risk factors associated with influenza A(H1N1)pdm09 outcome: challenges ahead.

Med Microbiol Immunol 2018 Oct 10. Epub 2018 Oct 10.

Laboratory of Microbiology, School of Medicine, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.

Influenza remains an important threat for human health, despite the extensive study of influenza viruses and the production of effective vaccines. In contrast to virus genetics determinants, host genetic factors with clinical impact remained unexplored until recently. The association between three single nucleotide polymorphisms (SNPs) and influenza outcome in a European population was investigated in the present study. Read More

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October 2018
1 Read

Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

Int J Cancer 2018 Sep 27. Epub 2018 Sep 27.

Cancer Institute, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhibition, depending on the mechanism of action. In the present study, we conducted a two-phase analysis of two independently published genome-wide association studies (GWASs) for associations between genetic variants in a complement-related immunity gene-set and overall survival of non-small cell lung cancer (NSCLC). The GWAS dataset from Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial was used as the discovery, and multivariate Cox proportional hazards regression with false-positive report probability for multiple test corrections were performed to evaluate associations between 14,699 single-nucleotide polymorphisms (SNPs) in 111 genes and survival of 1,185 NSCLC patients. Read More

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September 2018
2 Reads
5.080 Impact Factor

Effect of metritis on endometrium tissue transcriptome during puerperium in Holstein lactating cows.

Theriogenology 2018 Dec 15;122:116-123. Epub 2018 Sep 15.

Applied Animal Biology, Faculty of Land and Food Systems, University of British Columbia, Vancouver, V6T 1Z4, Canada. Electronic address:

The objective of this prospective cohort study was to evaluate the effect of parity and uterine health status postpartum on the gene expression profile of the endometrium early post-partum. Twenty-four Holstein cows were randomly selected (16 multiparous (MP) and 8 primiparous (PP)) and endometrium biopsies were collected on days 1, 3, and 6 after calving and clinically monitored for metritis. Rectal temperature was measured twice and fever was defined as a temperature ≥39. Read More

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December 2018
4 Reads
1.800 Impact Factor

Complement Regulatory Genetic Mutations in the Setting of Autoimmune Thrombotic Thrombocytopenic Purpura: A Case Series.

Mayo Clin Proc Innov Qual Outcomes 2018 Mar 20;2(1):69-73. Epub 2017 Dec 20.

Department of Medicine, Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock.

Objective: To explore the benefits of adding eculizumab for the treatment of refractory autoimmune thrombotic thrombocytopenic purpura (iTTP) with complement dysregulation.

Patients And Methods: From January 1, 2014, through July 1, 2017, we identified patients with iTTP defined by ADAMTS13 (disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) levels less than 5% and the presence of ADAMTS13 inhibitor. Patients who progressed after receiving standard of care management for iTTP were subjected to a comprehensive evaluation to look for evidence of complement activation. Read More

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March 2018
7 Reads

The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Pediatr Nephrol 2018 Aug 23. Epub 2018 Aug 23.

Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands.

Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway (AP) convertases. Besides, some studies have indicated a role for properdin as an initiator of complement activity. Read More

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August 2018
3 Reads

Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases.

Front Immunol 2018 8;9:1851. Epub 2018 Aug 8.

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.

The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases. Some of them are primarily complement-mediated rare diseases, such as paroxysmal nocturnal hemoglobinuria, C3 glomerulonephritis, and atypical hemolytic uremic syndrome. Complement also plays a role in various multifactorial diseases that affect millions of people worldwide, such as ischemia reperfusion injury (myocardial infarction, stroke), age-related macular degeneration, and several neurodegenerative disorders. Read More

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August 2018
6 Reads

Biophysical analysis of sialic acid recognition by the complement regulator Factor H.

Glycobiology 2018 10;28(10):765-773

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.

Complement factor H (FH), an elongated and substantially glycosylated 20-domain protein, is a soluble regulator of the complement alternative pathway (AP). It contains several glycan binding sites which mediate recognition of α2-3-linked sialic acid (FH domain 20) and glycosaminoglycans (domains 6-8 and 19-20). FH also binds the complement C3-activation product C3b, a powerful opsonin and focal point for the formation of C3-convertases of the AP feedback loop. Read More

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October 2018
9 Reads

Visual similarity modulates visual size contrast.

Acta Psychol (Amst) 2018 Jun 15;188:122-130. Epub 2018 Jun 15.

Università di Parma, Italy.

Perception is relational: object properties are perceived in comparison to the spatiotemporal context rather than absolutely. This principle predicts well known contrast effects: For instance, the same sphere will feel smaller after feeling a larger sphere and larger after feeling a smaller sphere (the Uznadze effect). In a series of experiments, we used a visual version of the Uznadze effect to test whether such contrast effects can be modulated by organizational factors, such as the similarity between the contrasting inducer stimulus and the contrasted induced stimulus. Read More

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June 2018
1 Read

Human Properdin Modulates Macrophage: BCG Interaction Thrombospondin Repeats 4 and 5.

Front Immunol 2018 8;9:533. Epub 2018 May 8.

College of Health and Life Sciences, Brunel University London, London, United Kingdom.

can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we have shown that complement regulatory proteins such as factor H may interfere with pathogen-macrophage interactions during tuberculosis infection. Read More

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May 2018
8 Reads

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.

J Neuroinflammation 2018 May 14;15(1):141. Epub 2018 May 14.

Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Background: Microglial activation contributes to the neuropathology associated with chronic alcohol exposure and withdrawal, including the expression of inflammatory and anti-inflammatory genes. In the current study, we examined the transcriptome of primary rat microglial cells following incubation with alcohol alone, or alcohol together with a robust inflammatory stimulus.

Methods: Primary microglia were prepared from mixed rat glial cultures. Read More

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May 2018
3 Reads

Identification of clam plasma proteins that bind its pathogen Quahog Parasite Unknown.

Fish Shellfish Immunol 2018 Jun 30;77:214-221. Epub 2018 Mar 30.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

The hard clam (Mercenaria mercenaria) is among the most economically-important marine species along the east coast of the United States, representing the first marine resource in several Northeastern states. The species is rather resilient to infections and the only important disease of hard clams results from an infection caused by Quahog Parasite Unknown (QPX), a protistan parasite that can lead to significant mortality events in wild and aquacultured clam stocks. Though the presence of QPX disease has been documented since the 1960s, little information is available on cellular and molecular interactions between the parasite and the host. Read More

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June 2018
2 Reads

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

Intern Med J 2018 06;48(6):624-636

Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. Although TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal. Read More

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June 2018
11 Reads

Functional splicing analysis in an infantile case of atypical hemolytic uremic syndrome caused by digenic mutations in C3 and MCP genes.

J Hum Genet 2018 Jun 19;63(6):755-759. Epub 2018 Mar 19.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Pathogenic variants in specific complement-related genes lead to atypical hemolytic uremic syndrome (aHUS). Some reports have indicated that patients with digenic variants in these genes might present severer phenotypes. Upon detecting novel intronic variants, transcriptional analysis is necessary to prove pathogenicity; however, when intronic variants are located in intron 1 and, as a result, no transcript is produced, no appropriate method had been established to reveal the pathogenicity. Read More

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June 2018
11 Reads

Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome.

Authors:
H Terence Cook

Curr Opin Nephrol Hypertens 2018 May;27(3):165-170

Department of Medicine, Imperial College London, London, UK.

Purpose Of Review: The current review will discuss recent advances in our understanding of the pathology of C3 glomerulopathy and atypical haemolytic uremic syndrome (aHUS).

Recent Findings: C3 glomerulopathy and aHUS are associated with abnormalities of control of the alternative pathway of complement. Recent articles have provided new insights into the classification of C3 glomerulopathy and its relationship to idiopathic immune complex-mediated glomerulonephritis. Read More

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May 2018
3 Reads

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

Nephrology (Carlton) 2018 Jun;23(6):507-517

Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. While TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal. Read More

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June 2018
17 Reads

Chronic deep brain stimulation normalizes scalp EEG activity in isolated dystonia.

Clin Neurophysiol 2017 Nov 26;129(2):368-376. Epub 2017 Nov 26.

Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States. Electronic address:

Objective: To investigate cortical activity using scalp EEG in patients with isolated dystonia treated with chronic deep brain stimulation (DBS), on and off stimulation.

Methods: We analyzed 64-channel scalp EEG in 12 isolated dystonia patients treated with chronic DBS (7 generalized, 5 cervical/segmental; 7 globus pallidus (GP), 5 subthalamic nucleus (STN)), and 20 healthy age-matched controls. Recordings during rest and movement task, and clinical motor scores, were collected with DBS-on and during a 90-min DBS washout. Read More

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November 2017
5 Reads

Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal tubules.

Nephrology (Carlton) 2017 Dec 27. Epub 2017 Dec 27.

Department of Pediatric Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.

Aim: The aim of the present study was to screen and verify downstream genes involved in the epithelial mesenchymal transition (EMT) induced by paired box 2 (PAX2) in NRK-52E cells.

Methods: NRK-52E cells were transfected with lentivirus carrying PAX2 gene or no-load virus respectively. Total RNA was isolated 72 h after transfection from PAX2-overexpressing cells and control cells. Read More

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December 2017
8 Reads

Genetic Susceptibility to Postdiarrheal Hemolytic-Uremic Syndrome After Shiga Toxin-Producing Escherichia coli Infection: A Centers for Disease Control and Prevention FoodNet Study.

J Infect Dis 2018 Mar;217(6):1000-1010

Tennessee Department of Health, Nashville.

Background: Postdiarrheal hemolytic-uremic syndrome (D+HUS) following Shiga toxin-producing Escherichia coli (STEC) infection is a serious condition lacking specific treatment. Host immune dysregulation and genetic susceptibility to complement hyperactivation are implicated in non-STEC-related HUS. However, genetic susceptibility to D+HUS remains largely uncharacterized. Read More

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March 2018
10 Reads

Dominant C3 glomerulopathy: new roles for an old actor in renal pathology.

J Nephrol 2018 Aug 18;31(4):503-510. Epub 2017 Nov 18.

Department of Clinical and Molecular Medicine, University of Rome "La Sapienza", Rome, Italy.

Recently, a number of reports have described dominant C3 deposits in renal biopsies of patients with infection-related glomerulonephritis (GN). While acute post-infectious GN and membranoproliferative GN are commonly characterized by immune deposits containing C3 and/or C4, the absence of immunoglobulin (Ig) and/or immune complexes at light or electron microscopy is a rather unusual observation. Dominant C3 deposition is believed to result from the alternative pathway of complement activation via the C3bBb "tickover" convertase. Read More

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August 2018
4 Reads

Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity.

Immunol Invest 2017 Nov;46(8):816-832

b Division of Nephrology , UB Clinical and Translational Research Center , Buffalo , NY , USA.

The complement system which is a critical mediator of innate immunity plays diverse roles in the neuropathogenesis of HIV-1 infection such as clearing HIV-1 and promoting productive HIV-1 replication. In the development of HIV-1 associated neurological disorders (HAND), there may be an imbalance between complement activation and regulation, which may contribute to the neuronal damage as a consequence of HIV-1 infection. It is well recognized that opiate abuse exacerbates HIV-1 neuropathology, however, little is known about the role of complement proteins in opiate induced neuromodulation, specifically in the presence of co-morbidity such as HIV-1 infection. Read More

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November 2017
10 Reads

Green-fruited Solanum habrochaites lacks fruit-specific carotenogenesis due to metabolic and structural blocks.

J Exp Bot 2017 10;68(17):4803-4819

Repository of Tomato Genomics Resources, Department of Plant Sciences, University of Hyderabad, Hyderabad-500046, India.

Members of the tomato clade exhibit a wide diversity in fruit color, but the mechanisms governing inter-species diversity of coloration are largely unknown. The carotenoid profiles, carotenogenic gene expression and proteome profiles of green-fruited Solanum habrochaites (SH), orange-fruited S. galapagense, and red-fruited S. Read More

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October 2017
9 Reads

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

J Immunol 2017 10 30;199(8):2910-2920. Epub 2017 Aug 30.

Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway;

Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect on CC via suppression of the inflammasome and liver X receptor activation. Read More

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October 2017
8 Reads

Conditional, Genetically Encoded, Small Molecule-Regulated Inhibition of NFκB Signaling in RPE Cells.

Invest Ophthalmol Vis Sci 2017 08;58(10):4126-4137

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

Purpose: Nuclear factor κB (NFκB) is a ubiquitously expressed, proinflammatory transcription factor that controls the expression of genes involved in cell survival, angiogenesis, complement activation, and inflammation. Studies have implicated NFκB-dependent cytokines or complement-related factors as being detrimentally involved in retinal diseases, thus making inhibition of NFκB signaling a potential therapeutic target. We sought to develop a conditional and reversible method that could regulate pathogenic NFκB signaling by the addition of a small molecule. Read More

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August 2017
2 Reads

Complement in Non-Antibody-Mediated Kidney Diseases.

Front Med (Lausanne) 2017 12;4:99. Epub 2017 Jul 12.

Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

The complement system is part of the innate immune response that plays important roles in protecting the host from foreign pathogens. The complement components and relative fragment deposition have long been recognized to be strongly involved also in the pathogenesis of autoantibody-related kidney glomerulopathies, leading to direct glomerular injury and recruitment of infiltrating inflammation pathways. More recently, unregulated complement activation has been shown to be associated with progression of non-antibody-mediated kidney diseases, including focal segmental glomerulosclerosis, C3 glomerular disease, thrombotic microangiopathies, or general fibrosis generation in progressive chronic kidney diseases. Read More

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July 2017
8 Reads

Complement-Related Regulates Autophagy in Neighboring Cells.

Cell 2017 Jun;170(1):158-171.e8

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. Read More

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June 2017
12 Reads

The RNA-seq analysis suggests a potential multi-component complement system in oyster Crassostrea gigas.

Dev Comp Immunol 2017 11 20;76:209-219. Epub 2017 Jun 20.

Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian, 116023, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China. Electronic address:

The complement system is one of the major effector mechanisms of immune system, playing essential roles in both the innate and adaptive immune responses. In the present study, the counterparts of vertebrate complement components were identified by screening the sequenced genome of Crassostrea gigas, resulting in the identification of 792 gene models containing complement-related domains. The transcriptome of haemocytes at 6, 12 and 24 h post lipopolysaccharides (LPS) stimulation showed differential expression of 77 C1q domain containing proteins, 53 C-type lectins and 42 fibrinogen-related proteins. Read More

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November 2017
55 Reads

Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.

Kidney Int 2017 10 19;92(4):953-963. Epub 2017 Jun 19.

Department of Cellular and Molecular Medicine and Center for Biological Research and Center for Biomedical Network Research on Rare Diseases, Madrid, Spain. Electronic address:

IgA nephropathy (IgAN), a frequent cause of chronic kidney disease worldwide, is characterized by mesangial deposition of galactose-deficient IgA1-containing immune complexes. Complement involvement in IgAN pathogenesis is suggested by the glomerular deposition of complement components and the strong protection from IgAN development conferred by the deletion of the CFHR3 and CFHR1 genes (Δ). Here we searched for correlations between clinical progression and levels of factor H (FH) and FH-related protein 1 (FHR-1) using well-characterized patient cohorts consisting of 112 patients with IgAN, 46 with non-complement-related autosomal dominant polycystic kidney disease (ADPKD), and 76 control individuals. Read More

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October 2017
49 Reads
8.563 Impact Factor

Effects of partial replacement of fish meal by yeast hydrolysate on complement system and stress resistance in juvenile Jian carp (Cyprinus carpio var. Jian).

Fish Shellfish Immunol 2017 Aug 9;67:312-321. Epub 2017 Jun 9.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

A 10-week feeding trial was carried out to investigate the effects of dietary fish meal replacement by yeast hydrolysate (YH) on growth performance, complement system and stress resistance of juvenile Jian carp (Cyprinus carpio var. Jian) (initial average weight 19.44 ± 0. Read More

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August 2017
11 Reads

Complement in clinical medicine: Clinical trials, case reports and therapy monitoring.

Mol Immunol 2017 09 31;89:10-21. Epub 2017 May 31.

Department of Immunology, Oslo University Hospital, and K. G. Jebsen Inflammation Research Centre, University of Oslo, Norway; Research Laboratory Nordland Hospital, Bodø, and K. G. Jebsen TREC, University of Tromsø, Tromsø, Norway; Centre of Molecular Inflammation, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

Research during past decades made it evident that complement is involved in more tasks than fighting infections, but has important roles in other immune surveillance and housekeeping functions. If the balance between complement activation and regulation is out of tune, however, complement can quickly turn against the host and contribute to adverse processes that result in various clinical conditions. Whereas clinical awareness was initially focused on complement deficiencies, excessive activation and insufficient regulation are frequently the dominant factors in complement-related disorders. Read More

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September 2017
27 Reads

Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of from the Competent Vector .

Front Cell Infect Microbiol 2017 16;7:73. Epub 2017 Mar 16.

Biology Centre of the Czech Academy of Sciences, Institute of Parasitology Ceske Budejovice, Czechia.

The present concept of the transmission of Lyme disease from -infected sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. Therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for borreliosis. Read More

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September 2017
11 Reads

Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology.

Clin Exp Nephrol 2018 Feb 24;22(1):3-14. Epub 2017 Mar 24.

Renal Replacement Therapy, Division of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

The complement activation system plays important roles to maintain homeostasis in the host and to fight foreign invaders to protect the host. Therefore, the complement system is considered a core part of innate immunity which also cross-talks to acquired immunity. In the history of nephrology, the complement system is familiar to us, because complement protein or fragment deposition, including C3, C4, C1q, and/or C4d, is routinely estimated by immunohistochemistry to diagnose renal pathologies. Read More

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February 2018
4 Reads

Complement related kidney diseases: Recurrence after transplantation.

World J Transplant 2016 Dec;6(4):632-645

Maurizio Salvadori, Elisabetta Bertoni, Department of Renal Transplantation, Careggi University Hospital, 50139 Florence, Italy.

The recurrence of renal disease after renal transplantation is becoming one of the main causes of graft loss after kidney transplantation. This principally concerns some of the original diseases as the atypical hemolytic uremic syndrome (HUS), the membranoproliferative glomerulonephritis (MPGN), in particular the MPGN now called C3 glomerulopathy. Both this groups of renal diseases are characterized by congenital (genetic) or acquired (auto-antibodies) modifications of the alternative pathway of complement. Read More

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December 2016
4 Reads

Elevated serum complement C3 levels are associated with prehypertension in an adult population.

Clin Exp Hypertens 2017 5;39(1):42-49. Epub 2017 Jan 5.

a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.

Prehypertension is a public health epidemic associated with various adverse outcomes, but can be reversed by timely intervention. However, little attention has been paid to prehypertension. Complement C3 is a central hub of complement-related immune system. Read More

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February 2017
13 Reads

Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jan 6;1041-1042:19-26. Epub 2016 Dec 6.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address:

Cp40 is a 14-amino acid cyclic analog of the peptidic complement inhibitor compstatin that binds with sub-nanomolar affinity to complement component C3 and has already shown promise in various models of complement-related diseases. The preclinical and clinical development of this compound requires a robust, accurate, and sensitive method for quantitatively monitoring Cp40 in biological samples. In this study, we describe the development and validation of an ultra-high performance liquid chromatography electrospray mass spectrometry method for the quantitation of Cp40 in human and non-human primate (NHP) plasma. Read More

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January 2017
7 Reads

Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

J Exp Med 2016 10 3;213(11):2365-2382. Epub 2016 Oct 3.

Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305

Cell death and release of proinflammatory mediators contribute to mortality during sepsis. Specifically, caspase-11-dependent cell death contributes to pathology and decreases in survival time in sepsis models. Priming of the host cell, through TLR4 and interferon receptors, induces caspase-11 expression, and cytosolic LPS directly stimulates caspase-11 activation, promoting the release of proinflammatory cytokines through pyroptosis and caspase-1 activation. Read More

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October 2016
9 Reads

Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia.

Platelets 2017 Jun 13;28(4):409-413. Epub 2016 Oct 13.

a Department of Blood Group Serology and Transfusion Medicine , Medical University of Vienna , Vienna , Austria.

In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, we investigated the possibility of an additional complement-related pathogenic mechanism, where antibodies against the complement-regulatory factors CD55 and CD59 may directly interfere with normal complement function. Read More

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June 2017
3 Reads

Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.

J Immunol 2016 09 12;197(6):2353-61. Epub 2016 Aug 12.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109;

There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically paced CMs caused prolonged elevations of intracellular Ca(2+) concentrations during diastole, together with the appearance of spontaneous Ca(2+) transients. Read More

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September 2016
31 Reads

Age-Related Macular Degeneration: Genetics and Biology.

Asia Pac J Ophthalmol (Phila) 2016 Jul-Aug;5(4):229-35

From Narayana Nethralaya, Narayana Health City, Bangalore, India.

Age-related macular degeneration (AMD), widely prevalent across the globe, is a major stakeholder among adult visual morbidity and blindness, not only in the Western world but also in Asia. Several risk factors have been identified, including critical genetic factors, which were never imagined 2 decades ago. The etiopathogenesis is emerging to demonstrate that immune and complement-related inflammation pathway members chronically exposed to environmental insults could justifiably influence disease morbidity and treatment outcomes. Read More

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January 2017
5 Reads

Etiopathological mechanisms and clinical characteristics of hyperhemolysis syndrome in Spanish patients with thalassemia.

Ann Hematol 2016 Sep 9;95(9):1419-27. Epub 2016 Jul 9.

Department of Surgical and Medical Therapeutics, School of Medicine, University of Extremadura, Av. Elvas s/n 06071, Badajoz, Spain.

Hyperhemolysis syndrome (HHS) is characterized by severe intravascular hemolysis with a decrease in the reticulocyte count, which is triggered and aggravated by transfusion and cannot be explained by standard immunohematological studies. A nationwide study was conducted in order to retrospectively identify thalassemia patients with HHS in Spain in order to assess pre-disposing mechanisms for this syndrome. For this, the expression of adhesion (CD49, CD36) and complement-related molecules (C3a, CD59) and the levels of reticulocyte apoptosis and macrophage activation were measured in 4 thalassemia patients with HHS, 14 patients without HHS, and 10 healthy subjects. Read More

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September 2016
11 Reads

Transcriptome Analysis of the Innate Immunity-Related Complement System in Spleen Tissue of Ctenopharyngodon idella Infected with Aeromonas hydrophila.

PLoS One 2016 6;11(7):e0157413. Epub 2016 Jul 6.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Education, Shanghai 201306, PR China.

The grass carp (Ctenopharyngodon idella) is an important commercial farmed herbivorous fish species in China, but is susceptible to Aeromonas hydrophila infections. In the present study, we performed de novo RNA-Seq sequencing of spleen tissue from specimens of a disease-resistant family, which were given intra-peritoneal injections containing PBS with or without a dose of A. hydrophila. Read More

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August 2017
14 Reads

Alterations of the immune transcriptome in resistant and susceptible hard clams (Mercenaria mercenaria) in response to Quahog Parasite Unknown (QPX) and temperature.

Fish Shellfish Immunol 2016 Feb 12;49:163-76. Epub 2015 Dec 12.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, 11794, USA. Electronic address:

Quahog Parasite Unknown (QPX) is a fatal protistan parasite that causes severe losses in the hard clam (Mercenaria mercenaria) fisheries along the northeastern coast of the US. Field and laboratory studies of QPX disease have demonstrated a major role for water temperature and M. mercenaria genetic origin in disease development. Read More

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February 2016
4 Reads

Complement activation, regulation, and molecular basis for complement-related diseases.

EMBO J 2015 Nov 21;34(22):2735-57. Epub 2015 Oct 21.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

The complement system is an essential element of the innate immune response that becomes activated upon recognition of molecular patterns associated with microorganisms, abnormal host cells, and modified molecules in the extracellular environment. The resulting proteolytic cascade tags the complement activator for elimination and elicits a pro-inflammatory response leading to recruitment and activation of immune cells from both the innate and adaptive branches of the immune system. Through these activities, complement functions in the first line of defense against pathogens but also contributes significantly to the maintenance of homeostasis and prevention of autoimmunity. Read More

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November 2015
2 Reads

Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease.

Am J Geriatr Psychiatry 2015 Dec 24;23(12):1290-1296. Epub 2015 Jun 24.

Centre for Public Health, Queen's University of Belfast, UK.

Objectives: Given the clinical and pathological similarities between age-related macular degeneration (AMD) and Alzheimer disease (AD), to assess whether AMD-associated single nucleotide polymorphisms (SNPs), including those from complement-related genes, are associated with AD.

Design: A case-control association study-type design.

Setting: A UK tertiary care dementia clinic. Read More

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December 2015
4 Reads

Necroinflammation in Kidney Disease.

J Am Soc Nephrol 2016 Jan 2;27(1):27-39. Epub 2015 Sep 2.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany; and

The bidirectional causality between kidney injury and inflammation remains an area of unexpected discoveries. The last decade unraveled the molecular mechanisms of sterile inflammation, which established danger signaling via pattern recognition receptors as a new concept of kidney injury-related inflammation. In contrast, renal cell necrosis remained considered a passive process executed either by the complement-related membrane attack complex, exotoxins, or cytotoxic T cells. Read More

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January 2016
2 Reads

Advances and challenges in the management of complement-mediated thrombotic microangiopathies.

Ther Adv Hematol 2015 Aug;6(4):171-85

Department of Paediatric Nephrology, Radboud University Medical Centre, Amalia Children's Hospital, Nijmegen, The Netherlands.

Complement activation plays a major role in several renal pathophysiological conditions. The three pathways of complement lead to C3 activation, followed by the formation of the anaphylatoxin C5a and the terminal membrane attack complex (MAC) in blood and at complement activating surfaces, lead to a cascade of events responsible for inflammation and for the induction of cell lysis. In case of ongoing uncontrolled complement activation, endothelial cells activation takes place, leading to events in which at the end thrombotic microangiopathy can occur. Read More

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August 2015
14 Reads

Stereospecific nickel-catalyzed cross-coupling reactions of benzylic ethers and esters.

Acc Chem Res 2015 Aug 21;48(8):2344-53. Epub 2015 Jul 21.

Department of Chemistry, University of California, Irvine, California 92697-2025, United States.

This Account presents the development of a suite of stereospecific alkyl-alkyl cross-coupling reactions employing nickel catalysts. Our reactions complement related nickel-catalyzed stereoconvergent cross-coupling reactions from a stereochemical and mechanistic perspective. Most reactions of alkyl electrophiles with low-valent nickel complexes proceed through alkyl radicals and thus are stereoablative; the correct enantioselective catalyst can favor the formation of one enantiomer. Read More

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August 2015
5 Reads