Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection.
- Ajitanuj Rattan,
- Shailesh D Pawar,
- Renuka Nawadkar,
- Neeraja Kulkarni,
- Girdhari Lal,
- Jayati Mullick,
- Arvind Sahu
PLoS Pathog 2017 Mar 16;13(3):e1006248. Epub 2017 Mar 16.
National Centre for Cell Science, S. P. Pune University Campus, Ganeshkhind, Pune, India.
The pandemic influenza A(H1N1) 2009 virus caused significant morbidity and mortality worldwide thus necessitating the need to understand the host factors that influence its control. Previously, the complement system has been shown to provide protection during the seasonal influenza virus infection, however, the role of individual complement pathways is not yet clear. Here, we have dissected the role of intact complement as well as of its individual activation pathways during the pandemic influenza virus infection using mouse strains deficient in various complement components. Read More