175,653 results match your criteria Complement Deficiencies


Multiple integrin ligands provide a highly adhesive and osteoinductive surface that improves selective cell retention technology.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China. Electronic address:

Among various bone tissue engineering strategies, selective cell retention (SCR) technology has been used as a practical clinical method for bone graft manufacturing in real time. The more mesenchymal stem cells (MSCs) are retained, the better the osteoinductive microenvironment provided by the scaffold, which in turn promotes the osteogenesis of the SCR-fabricated bone grafts. Integrin receptors are crucial to cell-matrix adhesion and signal transduction. Read More

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December 2018

Lectin Complement Pathway in Emphysema.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

National Jewish Health, Medicine, Denver, Colorado, United States.

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December 2018

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.

PLoS One 2018 17;13(12):e0208042. Epub 2018 Dec 17.

Department of Medicine, University of California San Francisco/ San Francisco VA Medical Center, San Francisco, California, United States of America.

Background: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study.

Methods And Results: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. Read More

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December 2018

Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Nutritional strategies for psoriasis: current scientific evidence in clinical trials.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8537-8551

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Objective: Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Read More

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December 2018

Minimum Information about an Uncultivated Virus Genome (MIUViG).

Nat Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. Read More

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December 2018

Seeing the forest through different trees: A social psychological perspective of work addiction.

J Behav Addict 2018 Dec 17:1-5. Epub 2018 Dec 17.

2 Institute of Psychology, ELTE Eötvös Loránd University , Budapest, Hungary.

We live in exciting times for the scientific study of work addiction, given its increased relevance and the diverse perspectives one might take to approach this phenomenon. Simultaneously, this field does not appear to be unified as a result of several misleading myths, which are addressed by the debate paper of Griffiths et al. (2018). Read More

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December 2018

Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Dec 17:e1546. Epub 2018 Dec 17.

Consumer Products Safety Unit, Directorate F - Health, Consumers and Reference Materials, European Commission Joint Research Centre (JRC), Ispra (VA), Italy.

As nanomedicines have the potential to address many currently unmet medical needs, the early identification of regulatory requirements that could hamper a smooth translation of nanomedicines from the laboratory environment to clinical applications is of utmost importance. The blood system is especially relevant as many nanomedicinal products that are currently under development are designed for intravenous administration and cells of the blood system will be among the first biological systems exposed to the injected nanomedicine. This review collects and summarizes the current knowledge related to the blood compatibility of nanomedicines and nanomaterials with a potential use in biomedical applications. Read More

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December 2018

Improving the rates of Aspergillus detection: an update on current diagnostic strategies.

Expert Rev Anti Infect Ther 2018 Dec 17:1-12. Epub 2018 Dec 17.

d Division of Infectious Diseases, Department of Medicine , University of California-San Diego , San Diego , CA , USA.

Introduction: The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, and ranges from invasive aspergillosis (IA) to chronic pulmonary aspergillosis (CPA). Early and reliable diagnosis of Aspergillus disease is important to decrease associated morbidity and mortality. Read More

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December 2018

Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes.

Mol Microbiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond, including bacterial virulence factors. Thus, proteins involved in disulfide bond formation represent good targets for the development of inhibitors that can act as antibiotics or anti-virulence agents, resulting in the simultaneous inactivation of several types of virulence factors. Here, we present evidence that the disulfide bond forming enzymes, DsbB and VKOR, are required for P. Read More

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December 2018

Assessment of groundwater quality and remediation in karst aquifers: A review.

Groundw Sustain Dev 2019 Apr 22;8:104-121. Epub 2018 Oct 22.

Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA.

Karst aquifers, capable of storing and transmitting large amount of water, are the main source of drinking water in many regions worldwide. Their excessive permeability leads to an enhanced vulnerability to retain and spread the contamination accordingly. From sustainability perspective, the environmental, economic and social impacts of karst contamination on water resources management are gaining more attention. Read More

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A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the SSL7 Protein.

Front Immunol 2018 29;9:2822. Epub 2018 Nov 29.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases. As general inhibition of the complement system may jeopardize patient health due to increased susceptibility to infections, the development of pathway-specific complement therapeutics has been a long-lasting goal over the last decades. Read More

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November 2018

Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain.

Front Psychol 2018 29;9:2400. Epub 2018 Nov 29.

Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Although generalized muscle pain, tiredness, anxiety, and depression are commonly present among chronic widespread pain (CWP) patients, the molecular mechanisms behind CWP are not fully elucidated. Moreover, the lack of biomarkers often makes diagnosis and treatment problematic. In this study, we investigated the correlation between pain intensity, psychological distress, and plasma proteins among CWP patients and controls (CON). Read More

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November 2018

Taking Others as a Mirror: Contingent Social Comparison Promotes Task Engagement.

Front Hum Neurosci 2018 28;12:476. Epub 2018 Nov 28.

School of Business and Management, Shanghai International Studies University, Shanghai, China.

Social comparison implemented in an informational while not controlling manner can be motivating. In order to directly examine the effect of contingent social comparison on one's task engagement, we manipulated social comparison in an experimental study and adopted an electrophysiological approach to measure one' task engagement. In this experiment, we engaged the participants in a modified stop-watch (SW) task which requires a button press to stop the watch within a given time interval and instructed the participants to either play alone or simultaneously play with a same-sex counterpart. Read More

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November 2018

Identification of human plasma C1 inhibitor as a target protein for staphylococcal superantigen-like protein 5 (SSL5).

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan. Electronic address:

The family of staphylococcal superantigen-like proteins (SSLs) have a structure similar to bacterial superantigens but exhibit no superantigenic activity. These exoproteins have recently been shown to disturb the host immune defense system. One family member, SSL5, was reported to bind to human leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) and matrix metalloproteinase-9 (MMP-9) and to interfere with leukocyte trafficking. Read More

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December 2018

Bringing benign ectomesenchymal odontogenic tumours to the lab: an in vitro study using an organotypic culture model.

J Oral Pathol Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Pathology, Basic Sciences Institute, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Brazil.

Background: Benign neoplasms exhibit most of the cellular phenomena considered hallmarks of cancer, except the capacity to metastasize. Thus, the elucidation of the mechanisms associated with the progression of benign neoplasms may complement and clarify the mechanisms involved in carcinogenesis. Benign odontogenic tumours often result in facial deformities and morbidities, and have complex pathogenesis, mainly due to the diversity of interactions between the odontogenic epithelium and the ectomesenchyme. Read More

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December 2018

The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Shanghai Taiyin Biotech Co., Ltd., Shanghai, 201203, China.

Hyperosmolality has been commonly investigated due to its effects on the production and quality characteristics of monoclonal antibodies (mAbs) produced in CHO cell fed-batch cultures. However, the application of hyperosmolality at different times and its effect on biopotency have seldom been researched, especially in perfusion culture. In our study, different degrees of hyperosmolality induced by sodium chloride were investigated in anti-IgE rCHO cell fed-batch cultures and anti-CD52 rCHO cell perfusion cultures during the initial and stable phases. Read More

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December 2018

Microglia Receptors in Animal Models of Traumatic Brain Injury.

Mol Neurobiol 2018 Dec 16. Epub 2018 Dec 16.

Department of Bioengineering, New Jersey Institute of Technology, 111 Lock Street, Room105 CHEN bldg, Newark, NJ, 07102, USA.

Microglia have been implicated as a key mediator of chronic inflammation following traumatic brain injury (TBI). The animal models of TBI vary significantly based on the type of brain injury (focal versus diffuse). This has made it extremely difficult to assess the role of microglia and the window of microglia activation. Read More

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December 2018

Thrombotic microangiopathy in a patient with eosinophilic granulomatosis with polyangiitis: case-based review.

Rheumatol Int 2018 Dec 15. Epub 2018 Dec 15.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.

The correct diagnosis, classification and therapeutic management of thrombotic microangiopathies (TMA) continue to be a challenge for the clinician. We report a rare case of eosinophilic granulomatosis with polyangiitis (EGPA) as a trigger for complement-mediated TMA in a 57-year-old man who was successfully treated with corticoids, cyclophosphamide and therapeutic plasma exchange. Additionally, we review few other cases reported in the literature and the pathophysiological pathway of association between TMA and EGPA. Read More

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December 2018
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Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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December 2018

Tractor rollover fatalities, analyzing accident scenario.

J Safety Res 2018 Dec 5;67:99-106. Epub 2018 Oct 5.

Department of Agricultural and Food Sciences, University of Bologna, Italy.

Introduction: In many countries, traditional data sources for collecting injuries of workers covered by compulsory accident insurance have recently been integrated by new observatories whose results may differ. A comparative analysis of the Italian data collection systems related to fatal tractor accidents in agriculture was performed focusing on tractor rollover fatalities with the aim of analyzing the accident scenario.

Method: Data from the Operational Archives of the Italian Workers Compensation Authority (INAIL), which collects injuries of workers covered by compulsory accident insurance and those of the National Surveillance System (INAIL_ASL), which provides narrative text reports of work-related fatal accidents have been analyzed and compared to the information collected by the INAIL Observatory. Read More

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December 2018

Distribution of mycotoxins produced by Penicillium spp. inoculated in apple jam and crème fraiche during chilled storage.

Int J Food Microbiol 2018 Dec 7;292:13-20. Epub 2018 Dec 7.

University of Natural Resources and Life Sciences, Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad-Lorenz-Str. 20, 3430 Tulln, Austria.

Estimations of consumer exposure to mycotoxins through surveillance of mycotoxins in the food trade are well described, but the exposure due to mouldy food in private homes is not known, and may result from removing visible mould on food and eating the rest. In this study, we followed the growth of Penicillium expansum on the surface of apple jam and Penicillium verrucosum on crème fraiche, as well as production and distribution of fungal metabolites throughout the sample (approx. 6 cm high divided into three equal layers), using a multianalyte method, over time (up to 28 days) and at 4, 8 and 15 °C. Read More

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December 2018
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The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Avian pathogenic Escherichia coli (APEC) causes severe respiratory and systemic diseases in poultry. The wzy gene encodes the O-antigen polymerase (Wzy), which plays an important role in the synthesis of the lipopolysaccharide (LPS) of bacteria. However, the function of the wzy gene in APEC remains unclear. Read More

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December 2018

Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1.

Transgenic Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.

Herein, we successfully generated transgenic pigs expressing both soluble human tumor necrosis factor receptor I IgG-Fc (shTNFRI-Fc) and human hemagglutinin (HA)-tagged-human heme oxygenase-1 (hHO-1) without Gal epitope. Healthy cloned pigs were produced by somatic cell nuclear transfer (SCNT) using the genetically modified cells. The genetic disruption of the GGTA1 genes and absence of expression of BS-IB4 lectin in tail-derived fibroblast of the SCNT-generated piglets were successfully confirmed. Read More

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December 2018

Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

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December 2018
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CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.

Nat Commun 2018 Dec 14;9(1):5316. Epub 2018 Dec 14.

Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, SW7 2AZ, UK.

The membrane attack complex (MAC) is one of the immune system's first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the membrane barrier remains unclear. Read More

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December 2018

Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Epidemiology (C.Z., Z.Z., A.W., Tan Xu, X.B., H.P., J.Y., L.H., Tian Xu, Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Preventive Medicine (L.H.), Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Nantong; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology; Department of Neurology (J.W.), Yutian County Hospital, Tangshan; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Taian; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Tongliao; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.

Objective: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.

Methods: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. Read More

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December 2018

Supported Internet-Delivered Cognitive Behavioral Therapy Programs for Depression, Anxiety, and Stress in University Students: Open, Non-Randomised Trial of Acceptability, Effectiveness, and Satisfaction.

JMIR Ment Health 2018 Dec 14;5(4):e11467. Epub 2018 Dec 14.

Department of Psychology, University of Minnesota, Minneapolis, MN, United States.

Background: Many university campuses have limited mental health services that cannot cope with the high demand. One alternative is to use internet-delivered cognitive behavioral therapy (iCBT) as a way of tackling barriers such as lack of availability and scheduling issues.

Objective: This study aimed to assess feasibility, acceptability, effectiveness, and satisfaction of a supported iCBT intervention offering 3 programs on depression, anxiety, and stress to university students. Read More

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December 2018

A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection.

Vaccine 2018 Dec 12. Epub 2018 Dec 12.

Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, United States. Electronic address:

Vaccines for prevention and treatment of genital herpes are high public health priorities. Our approach towards vaccine development is to focus on blocking virus entry mediated by herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) and to prevent the virus from evading complement and antibody attack by blocking the immune evasion domains on HSV-2 glycoproteins C (gC2) and E (gE2), respectively. HSV-2 gC2 and gE2 are expressed on the virion envelope and infected cell surface where they are potential targets of antibodies that bind and block their immune evasion activities. Read More

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December 2018

Cold evoked potentials: Acquisition from cervical dermatomes.

Neurophysiol Clin 2018 Dec 11. Epub 2018 Dec 11.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland. Electronic address:

Introduction: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. Read More

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December 2018
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Can immune biomarkers predict infections in solid organ transplant recipients? A review of current evidence.

Transplant Rev (Orlando) 2018 Oct 9. Epub 2018 Oct 9.

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Australia; Department of Nephrology, Monash Medical Centre, Clayton, Victoria 3168, Australia. Electronic address:

Despite improvements in graft survival, solid organ transplantation is still associated with considerable infection induced morbidity and mortality. If we were able to show that serious infection risk was associated with excessive suppression of immune capacity, we would be justified in "personalizing" the extent of immunosuppression by carefully monitored reduction to see if we can improve immune compromize without increasing the risk of rejection. Reliable biomarkers are needed to identify this patients at an increased risk of infection. Read More

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October 2018
2 Reads

Saliva of hematophagous insects: a multifaceted toolkit.

Curr Opin Insect Sci 2018 Oct 24;29:102-109. Epub 2018 Jul 24.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.

Transcriptomic, proteomic and genomic studies significantly improved our understanding of the complexity of blood feeding insect saliva providing unparalleled evolutionary insights. Salivary genes appeared to be under strong selective pressure with gene duplication and functional diversification being a powerful driver in the evolution of novel salivary genes/functions. The first insect salivary proteins responsible for complement inhibition were identified and a widespread mechanism of action shared by unrelated salivary protein families was recognized and named kratagonism. Read More

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October 2018

Omics and the metabolic function of insect-microbial symbioses.

Authors:
Angela E Douglas

Curr Opin Insect Sci 2018 Oct 26;29:1-6. Epub 2018 May 26.

Department of Entomology and Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853, USA. Electronic address:

Omic studies of metabolic interactions between insects and their microbial symbionts enable us to construct precise hypotheses, especially regarding the metabolic services provided by microbial partners and the identity of metabolites exchanged between microorganisms and the insect host. Valuable sources of information include the complement of metabolism-related genes in the microbial partners, and differences in the abundance of transcripts, proteins or metabolites, either between microbe-bearing organs and the whole body or between insects bearing and lacking microbial symbionts. Hypotheses generated from omic data can, most productively, be tested by experiments using reverse genetics for precise manipulation of the gene expression. Read More

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October 2018

Back to the roots: the importance of using simple insect societies to understand the molecular basis of complex social life.

Curr Opin Insect Sci 2018 Aug 12;28:33-39. Epub 2018 Apr 12.

Institute of Organismic and Molecular Evolution, Johannes Gutenberg University, Mainz, Germany. Electronic address:

The evolutionary trajectories toward insect eusociality come in two broad forms. In species like wasps, bees, and ants, the first helpers remained at the nest primarily to help with brood care. In species like aphids and termites, on the other hand, nest defense was initially the primary ecological driving force. Read More

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August 2018
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Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS Ⅲ), and its challenge against Aeromonas hydrophila infection.

Fish Shellfish Immunol 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, PR China.

The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 7.48g). Read More

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December 2018

Characterization of locomotor response to psychostimulants in the parthenogenetic marbled crayfish (Procambarus fallax forma virginalis): A promising model for studying the neural and molecular mechanisms of drug addiction.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

J.P. Scott Center for Neuroscience, Mind & Behavior, and Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.

Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to the use of invertebrate model systems to complement the research of drug-induced reward in mammalian systems. Invertebrates, such as crayfish, offer excellent model systems to help reveal the underlying mechanisms of drug addiction as they retain the ancestral neural reward circuit that is evolutionarily conserved across taxa, and they possess relatively few, large neurons, laid out in an accessible, modularly organized nervous system. Read More

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December 2018

Ribosomal protein eL42 contributes to the catalytic activity of the yeast ribosome at the elongation step of translation.

Biochimie 2018 Dec 11. Epub 2018 Dec 11.

Sorbonne Université, Campus Pierre et Marie Curie, Laboratoire "Enzymologie de l'ARN", SU-UR6; (Bâtiment B); Case courrier 60 - 4, Place Jussieu, F-75252, Paris Cedex 05, France.

The GGQ minidomain of the ribosomal protein eL42 was previously shown to contact the CCA-arm of P-site bound tRNA in human ribosome, indicating a possible involvement of the protein in the catalytic activity. Here, using Schizosaccharomyces pombe (S. pombe) cells, we demonstrate that the GGQ minidomain and neighboring region of eL42 is critical for the ribosomal function. Read More

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December 2018

MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Physiology and Biophysics, Cardiovascular Research Institute of Vermont, University of Vermont, Burlington, VT, United States. Electronic address:

Rationale: Truncation mutations in the MYBPC3 gene, encoding for cardiac myosin-binding protein C (MyBP-C), are the leading cause of hypertrophic cardiomyopathy (HCM). Whole heart, fiber and molecular studies demonstrate that MyBP-C is a potent modulator of cardiac contractility, but how these mutations contribute to HCM is unresolved.

Objectives: To readdress whether MYBPC3 truncation mutations result in loss of MyBP-C content and/or the expression of truncated MyBP-C from the mutant allele and determine how these mutations effect myofilament sliding in human myocardium. Read More

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December 2018
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Experiences of treadmill walking with non-immersive virtual reality after stroke or acquired brain injury - A qualitative study.

PLoS One 2018 14;13(12):e0209214. Epub 2018 Dec 14.

Research group for Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: It is well known that physical activity levels for persons after stroke or acquired brain injuries do not reach existing recommendations. Walking training is highly important since the ability to walk is considered to be a meaningful occupation for most people, and is often reduced after a brain injury. This suggests a need to innovate stroke rehabilitation, so that forms of walking training that are user-friendly and enjoyable can be provided. Read More

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December 2018

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment.

PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.

Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More

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December 2018

A data-driven individual-based model of infectious disease in livestock operation: A validation study for paratuberculosis.

PLoS One 2018 14;13(12):e0203177. Epub 2018 Dec 14.

Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Tower Road, Ithaca, New York, United States of America.

Chronic livestock diseases cause large financial loss and affect animal health and welfare. Controlling these diseases mostly requires precise information on both individual animal and population dynamics to inform the farmer's decisions, but even successful control programmes do by no means assure elimination. Mathematical models provide opportunities to test different control and elimination options rather than implementing them in real herds, but these models require robust parameter estimation and validation. Read More

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December 2018

Is diet management helpful in familial hypercholesterolemia?

Authors:
Samuel S Gidding

Curr Opin Clin Nutr Metab Care 2018 Dec 13. Epub 2018 Dec 13.

FH Foundation, Pasadena, California, USA.

Purpose Of Review: Familial hypercholesterolemia is a genetic condition where low-density lipoprotein (LDL) receptor defects cause severe elevations of LDL cholesterol. As significant LDL-lowering effects are needed, medication is considered the cornerstone of therapy, and dietary therapy has received less emphasis. This review will re-visit older studies of diet intervention and new insights from genetic and mechanistic studies to determine the value of diet management for familial hypercholesterolemia patients. Read More

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December 2018

Emerging immunotherapies for autoimmune kidney disease.

Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.

a Department of Medicine , Duke University Medical Center , Durham , NC , USA.

Autoimmunity is a leading cause of chronic kidney disease and loss of native and transplanted kidneys. Conventional immunosuppressive therapies can be effective but are non-specific, noncurative, and risk serious side effects such as life-threatening infection and cancer. Novel therapies and targeted interventions are urgently needed. Read More

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December 2018

Accessibility of Uranyl-Plutonium Complex Supported by a Polypyrrolic Macrocycle: An Implication for Experimental Synthesis.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

Key Laboratory of Functional Inorganic Material Chemistry (Ministry of Education), School of Chemistry and Materials Science , Heilongjiang University , Harbin 150080 , China.

The reaction of (THF)(HL)(UO) (L is a tetra-anion of polypyrrolic macrocycle) with AnCp (Cp = cyclopentadienyl) afforded two intriguing cation-cation interaction (CCI) complexes (i.e., uranyl-Np and -U), but did not yield the uranyl-Pu analogue. Read More

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December 2018
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An empirical evaluation of multivariate lesion behaviour mapping using support vector regression.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Centre of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Multivariate lesion behaviour mapping based on machine learning algorithms has recently been suggested to complement the methods of anatomo-behavioural approaches in cognitive neuroscience. Several studies applied and validated support vector regression-based lesion symptom mapping (SVR-LSM) to map anatomo-behavioural relations. However, this promising method, as well as the multivariate approach per se, still bears many open questions. Read More

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December 2018

Systemic disrupting the homeostasis of tRNA isopentenyltransferase causes growth and development abnormalities in Bombyx mori.

Insect Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Silkworm Genome Biology, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China.

Isopentenylation at A37 (i A37) of some transfer RNAs (tRNAs) plays a vital role in regulating the efficiency and fidelity of protein synthesis. However, whether insects, which are well-known for their highly efficient protein synthesis machinery, employ this regulatory mechanism remains uninvestigated. In the current study, a candidate tRNA isopentenyltransferase (IPT) gene with three alternative splicing isoforms (BmIPT1-BmIPT3) was identified in Bombyx mori (silkworm). Read More

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December 2018

Defining the complement C3 binding site and the antigenic region of Haemonchus contortus GAPDH.

Parasite Immunol 2018 Dec 12:e12611. Epub 2018 Dec 12.

Division of Biochemistry, ICAR-Indian Veterinary Research Institute, Izatnagar, India, 243122.

Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of the innate immunity, by binding to complement C3. Read More

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December 2018

TREM2 triggers microglial density and age-related neuronal loss.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Neural Regeneration, Institute of Reconstructive Neurobiology, University Hospital of Bonn, University of Bonn, Bonn, Germany.

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Read More

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December 2018