12,519 results match your criteria Compartment Syndrome

The Role of Endovascular Repair of Popliteal Arterial Injuries in the Acute Setting.

Ann Vasc Surg 2022 Jun 24. Epub 2022 Jun 24.

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, 22 S Greene St, Baltimore, Maryland, 21201, USA.

Objectives: The role of endovascular surgery in the treatment of popliteal arterial injuries is not well established. As with other popliteal pathology, open repair has traditionally been considered the gold standard. As data has accumulated and technology advanced, however, a reassessment of the role of endovascular surgery is warranted. Read More

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Intra-Abdominal Hypertension: A Systemic Complication of Severe Acute Pancreatitis.

Medicina (Kaunas) 2022 Jun 10;58(6). Epub 2022 Jun 10.

Critical Care Unit and Gastroenterology Section, Department of Internal Medicine, Clinical Hospital, University of Chile, Santiago 8380456, Chile.

Patients with severe acute pancreatitis (SAP) present complications and organ failure, which require treatment in critical care units. These extrapancreatic complications determine the clinical outcome of the disease. Intra-abdominal hypertension (IAH) deteriorates the prognosis of SAP. Read More

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Assessment of Orbital Compartment Pressure: A Comprehensive Review.

Diagnostics (Basel) 2022 Jun 16;12(6). Epub 2022 Jun 16.

Department of Ophthalmology, Cantonal Hospital Aarau, CH-5001 Aarau, Switzerland.

The orbit is a closed compartment defined by the orbital bones and the orbital septum. Some diseases of the orbit and the optic nerve are associated with an increased orbital compartment pressure (OCP), e.g. Read More

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Immunomodulatory role of mitochondrial damps: A missing link in pathology?

FEBS J 2022 Jun 22. Epub 2022 Jun 22.

Cardio-Respiratory Disease Biology, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110007, India.

In accordance with the endosymbiotic theory, mitochondrial components bear characteristic prokaryotic signatures which act as immunomodulatory molecules when released into the extramitochondrial compartment. These endogenous immune triggers, called mitochondrial Damage Associated Molecular Patterns (mtDAMPs) have been implicated in the pathogenesis of various diseases, yet their role remains largely unexplored. In this review, we summarize the available literature on mtDAMPs in diseases, with a special focus on respiratory diseases. Read More

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Emergency open drainage of massive hemoperitoneum and early stage left hepatectomy for abdominal compartment syndrome due to hepatocellular carcinoma rupture: a case report.

Surg Case Rep 2022 Jun 22;8(1):122. Epub 2022 Jun 22.

Department of Surgery, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77, Higashinaniwa, Amagasaki, Hyogo, Japan.

Background: Spontaneous rupture is one of the most life-threatening complications of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) effectively achieves hemostasis in patients with hemodynamic instability. However, there have been no reports of abdominal compartment syndrome (ACS) caused by massive intra-abdominal hematoma after TAE. Read More

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Implementation of Clinical Decision Support on Emergency Department Delivery of Human Rabies Immune Globulin.

JAMA Netw Open 2022 Jun 1;5(6):e2216631. Epub 2022 Jun 1.

Department of Pharmacy, Houston Methodist, Houston, Texas.

Importance: Fatal human rabies infections can be prevented through appropriate rabies postexposure prophylaxis (PEP). Errors in patient selection and administration of human rabies immune globulin in the emergency department (ED) setting were identified in a previous study of rabies PEP administration.

Objective: To test the a priori hypothesis that implementation of a rabies PEP bundle in the ED would improve full adherence to 6 human rabies immune globulin quality indicators compared with preimplementation controls. Read More

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Civilian Ballistic Femoral Shaft Fractures Compared With Blunt Femur Shaft Fractures.

J Orthop Trauma 2022 Jul;36(7):355-360

Department of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham, AL; and.

Objective: To assess ballistic femoral shaft fracture outcomes in comparison with closed and open femoral shaft fractures sustained by blunt mechanisms. We hypothesized that ballistic femoral shaft fractures would have similar outcomes to blunt open fractures.

Design: Retrospective cohort study. Read More

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SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters.

Nat Commun 2022 Jun 20;13(1):3519. Epub 2022 Jun 20.

Department of Pathology, University of Veterinary Medicine, Foundation, Hanover, Germany.

Since its discovery in 2019, multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and associated pathology in the upper and lower respiratory tracts of Syrian golden hamsters at 4 days post intranasal SARS-CoV-2 Omicron infection, in comparison to infection with variants of concern (VOCs) Gamma and Delta as well as ancestral strain 614 G. Pathological changes in the upper and lower respiratory tract of VOC Omicron infected hamsters are milder than those caused by other investigated strains. Read More

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Upper Extremity Crotalid Envenomation: A Review of Incidence and Recent Trends in Management of Snakebites.

J Hand Surg Am 2022 Jun 17. Epub 2022 Jun 17.

Georgia Hand, Shoulder and Elbow, Atlanta, GA.

Purpose: The goal of this study was to evaluate the recent trends in the management of upper extremity Crotalid envenomation in the state of Georgia, United States.

Methods: A retrospective review of the Georgia Poison Center database looking at the reported snakebites to the upper extremity between 2015 and 2020 was performed. Patient demographics, timing and location of injury, severity of envenomation, treatment, including use of antivenin and surgical intervention, and reported complications related to the use of antivenin was extracted. Read More

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Predictors of Positive Outcomes and a Scoring System to Guide Management After Fasciotomy for Chronic Exertional Compartment Syndrome.

Orthop J Sports Med 2022 Jun 14;10(6):23259671221101328. Epub 2022 Jun 14.

Trauma and Orthopaedic Department, Royal United Hospitals, Bath, UK.

Background: Chronic exertional compartment syndrome (CECS) of the lower limb usually responds well to fasciotomy in patients with failed nonoperative treatment. Careful history taking and compartment pressure testing are both required to accurately diagnose CECS.

Purposes: To evaluate patients with CECS after fasciotomy to establish predictive criteria of positive outcomes and to develop a scoring system to aid clinicians in their management of such patients. Read More

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Pancarpal dissociation, a very rare type of injury: A case report.

Medicine (Baltimore) 2022 Jun 17;101(24):e29479. Epub 2022 Jun 17.

Department of Orthopaedic Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Pan-carpal dissociation is very rare injury and there is little information as to diagnosis, treatment, and prognosis of this injury.

Patient Concerns: A 35-year-man presented to our hospital with severe pain and swelling of the left wrist and forearm after slipping and falling while riding a motorcycle.

Diagnosis: The wrist simple radiographs demonstrated unrecognizable severe fracture-dislocation of the carpal bones concomitant with fractures of the radioulnar shaft. Read More

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Adherence to burn resuscitation guidelines reduces resuscitation fluids and mortality.

J Burn Care Res 2022 Jun 16. Epub 2022 Jun 16.

Division of Plastic Surgery, Department of Surgery, University of British Columbia.

In our province, regional recommendations for optimal fluid resuscitation were published in 2011 to improve the management of acute burn patients prior to transfer to a specialized burn center. The purpose of this study was to determine compliance with these provincial burn resuscitation guidelines and their subsequent impact on patient outcomes. A retrospective review of patients transferred to the provincial burn center after being initially managed at peripheral sites was performed from 2011 - 2019. Read More

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T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review.

Clin Rev Allergy Immunol 2022 Jun 16. Epub 2022 Jun 16.

Allergy Immunology Unit, Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

X-linked agammaglobulinaemia (XLA) is a primary immunodeficiency (PID) resulting from a defect in the B cell development. It has conventionally been thought that T cells play a major role in the development and function of the B cell compartment. However, it has also been shown that B cells and T cells undergo bidirectional interactions and B cells also influence the structure and function of the T cell compartment. Read More

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Bilateral Lower Extremity Compartment Syndrome Secondary to COVID-19 Myositis in a Young Vaccinated Woman.

Am Surg 2022 Jun 15:31348221083951. Epub 2022 Jun 15.

Department of Surgery, Division of Trauma Acute Care Surgery, and Surgical Critical Care, Reading Hospital, 419713Tower Health.

Coronavirus disease 2019 (COVID-19) typically manifests with respiratory symptoms and can ultimately progress to severe multiorgan failure. Viral myositis, systemic capillary leak syndrome, and arteriovenous thrombosis are atypical manifestations of COVID-19. We present a case of a 33-year-old woman, fully vaccinated against COVID-19, who developed myositis and shock. Read More

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Isolated Acute Lateral Compartment Syndrome in an Adolescent Athlete: A Case Report.

JBJS Case Connect 2022 04 15;12(2). Epub 2022 Jun 15.

Division of Pediatric Surgery, Department of Orthopedic Surgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Case: A 17-year-old adolescent boy presented with anterolateral, right leg pain and numbness of his right foot 2 days after participating in football practice. He denied a traumatic event, and radiographs were negative for fracture. His imaging and physical examination raised suspicion for acute compartment syndrome (ACS). Read More

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Wells Syndrome Presenting as Atypical Periorbital Cellulitis.

Ophthalmic Plast Reconstr Surg 2022 Jun 14. Epub 2022 Jun 14.

Department of Ophthalmology, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

A 62-year-old man presented with diffuse, painless, left-sided preseptal edema, erythema, and woody induration extending to the left temple. The induration generated an orbital compartment syndrome with markedly elevated intraocular pressure necessitating lateral canthotomy and cantholysis. Although atypical for an infectious etiology, empiric broad-spectrum intravenous antibiotics were initiated with no improvement. Read More

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Optimal Social Distancing Policy for COVID-19 Control in Korea: A Model-Based Analysis.

J Korean Med Sci 2022 Jun 13;37(23):e189. Epub 2022 Jun 13.

Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background: Since March 2020, when coronavirus disease 2019 (COVID-19) was declared a pandemic, many countries have applied unprecedented restrictive measures to contain the spread of the virus. This study aimed to explore the optimal social distancing policy for COVID-19 control in South Korea to safely reopen the society.

Methods: We developed an age-specific, deterministic compartment epidemic model to examine the COVID-19 control decision-making process, including the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 1 July 2021 and 30 December 2022. Read More

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Intra-abdominal hypertension in cardiac surgery patients: a multicenter observational sub-study of the Accuryn registry.

J Clin Monit Comput 2022 Jun 13. Epub 2022 Jun 13.

Department of Anesthesiology, Division of Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Intra-abdominal hypertension (IAH) is frequently present in the critically ill and is associated with increased morbidity and mortality. Conventionally, intermittent 'spot-check' manual measurements of bladder pressure in those perceived as high risk are used as surrogates for intra-abdominal pressure (IAP). True patterns of IAH remain unknown. Read More

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An alternative method for personalized tourniquet pressure in total knee arthroplasty: a prospective randomized and controlled study.

Sci Rep 2022 Jun 10;12(1):9652. Epub 2022 Jun 10.

Department of Joint Surgery and Sports Medicine, Changzheng Hospital, Naval Medical University, 415#, Fengyang Road, Huangpu District, Shanghai, 200003, China.

Tourniquet use always carries potential risks, which can range from mild transient functional impairments of thigh pain, skin blisters to severe permanent dysfunction of limb paralysis, nerve injuries or compartment syndrome. The ideal method for minimizing intraoperative tourniquet pressure (TP) for reducing postoperative complications remains controversial. In this prospective, randomized and controlled study, we reinvestigated an estimation formula for TP based on thigh circumferences and systolic blood pressure (SBP) with two traditional methods for TP determination in total knee arthroplasty (TKA): SBP plus 100 mmHg and a fixed value of 300 mmHg. Read More

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Reversing the Mismatch With Forefoot Striking to Reduce Running Injuries.

Front Sports Act Living 2022 19;4:794005. Epub 2022 May 19.

Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany.

Recent studies have suggested that 95% of modern runners land with a rearfoot strike (RFS) pattern. However, we hypothesize that running with an RFS pattern is indicative of an evolutionary mismatch that can lead to musculoskeletal injury. This perspective is predicated on the notion that our ancestors evolved to run barefoot and primarily with a forefoot strike (FFS) pattern. Read More

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[The glomerulus in all its states].

Rev Med Liege 2022 May;77(5-6):330-337

Service de Néphrologie, Dialyse et Transplantation CHU Liège, Belgique.

Glomerulonephritis are the result of an inflammatory hit to the glomerulus. They are rare and heterogeneous renal diseases. Each glomerular compartment can be affected. Read More

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Acute Hematogenous Osteomyelitis Resulting in Atraumatic Pediatric Forearm Compartment Syndrome.

J Am Acad Orthop Surg Glob Res Rev 2022 Jun 2;6(6). Epub 2022 Jun 2.

From the University of Maryland Medical Center (Dr. Shaw, Dr. Kish, and Dr. Pensy) and the R. Adams Cowley Shock Trauma Center, Baltimore, MD (Dr. Shaw, Dr. Kish, and Dr. Pensy).

Acute hematogenous osteomyelitis is well described after minor trauma in the pediatric population, with an incidence of 1 to 13 cases per 100,000 individuals. Compartment syndrome (CS) in children is a rare, but potentially devastating disease, classified as "cannot miss diagnosis." Compared with adults, CS may exhibit a variable presentation with a wide range of symptoms in children, often leading to delayed diagnosis. Read More

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Trauma-induced capillary leak syndrome after penetrating chest injury: Manifestation of massive ascites and pulmonary secretions aggravated by transfusion.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):863-866

Department of Surgery, National Medical Center, Seoul-Korea.

Trauma with prolonged shock can cause systemic capillary leak syndrome regardless of the site of injury and a transfusion can aggravate it. The systemic capillary leak induces both an abdominal compartment syndrome and pulmonary edema, and a transfusion can aggra-vate these sequelae within hours. In our case, 21-year-old man with a penetrating injury in his left thorax experienced delay in rescue and definitive surgery. Read More

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Risk Factors for Infection in Patients Undergoing Osteosynthesis for Tibial Plateau Fracture in a University Hospital.

Cureus 2022 Apr 29;14(4):e24587. Epub 2022 Apr 29.

Orthopedics and Traumatology, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, BRA.

Schatzker types IV to VI tibial plane fractures compromise the two tibial plateaus. Most cases involve joint deviation and require anatomic reduction and rigid fixation. Dual access and prolonged surgical time are factors that exert an influence on the occurrence of infection of the surgical wound and, consequently, the clinical outcome. Read More

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Population Pharmacokinetic Evaluation with External Validation of Tacrolimus in Chinese Primary Nephrotic Syndrome Patients.

Pharm Res 2022 Jun 1. Epub 2022 Jun 1.

Department of Nephrology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China.

Purpose: The generalizability of numerous tacrolimus population pharmacokinetic (popPK) models constructed to promote optimal tacrolimus dosing in patients with primary nephrotic syndrome (PNS) is unclear. This study aimed to evaluate the predictive performance of published tacrolimus popPK models for PNS patients with an external data set.

Methods: We prospectively collected 223 concentrations from 50 Chinese adult patients with PNS who were undergoing tacrolimus treatment. Read More

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Systematic review of innovative diagnostic tests for chronic exertional compartment syndrome.

Int J Sports Med 2022 Jun 1. Epub 2022 Jun 1.

Department of Surgery, Alrijne Hospital Location Leiderdorp, Leiderdorp, Netherlands.

The diagnosis chronic exertional compartment syndrome is traditionally linked to elevated intracompartmental pressures, although uncertainty regarding this diagnostic instrument is increasing. The aim of current review was to evaluate literature for alternative diagnostic tests. A search in line with PRISMA criteria was conducted. Read More

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Fetal sepsis: a cause of stillbirth.

J Matern Fetal Neonatal Med 2022 Jun 1:1-5. Epub 2022 Jun 1.

Fernandez Foundation, Hyderabad, India.

Infection is considered a leading cause of fetal death, responsible for approximately 20% of cases. Such estimates are derived from the frequency of acute histological chorioamnionitis and funisitis in cases of fetal death rather than direct detection of microorganisms in the fetal compartment. We report a case of clinically unexplained fetal death at 38 weeks of gestation in an uncomplicated pregnancy resulting in delivery of an appropriate-for-gestational-age fetus. Read More

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Elevated intra-abdominal pressure: A review of current knowledge.

World J Clin Cases 2022 Apr;10(10):3005-3013

Department of Heart Diseases, Wroclaw Medical University, Wroclaw 50-367, Poland.

Elevated intra-abdominal pressure (IAP) is a known cause of increased morbidity and mortality among critically ill patients. Intra-abdominal hypertension (IAH) and abdominal compartment syndrome can lead to rapid deterioration of organ function and the development of multiple organ failure. Raised IAP affects every system and main organ in the human body. Read More

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Treacle Sticks the Nucleolar Responses to DNA Damage Together.

Front Cell Dev Biol 2022 12;10:892006. Epub 2022 May 12.

Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

The importance of chromatin environment for DNA repair has gained increasing recognition in recent years. The nucleolus is the largest sub-compartment within the nucleus: it has distinct biophysical properties, selective protein retention, and houses the specialized ribosomal RNA genes (collectively referred to as rDNA) with a unique chromatin composition. These genes have high transcriptional activity and a repetitive nature, making them susceptible to DNA damage and resulting in the highest frequency of rearrangements across the genome. Read More

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