1,105,838 results match your criteria Comparison of Revascularization Procedures in Coronary Artery Disease

Neural optimal tracking control of constrained nonaffine systems with a wastewater treatment application.

Neural Netw 2021 Jun 2;143:121-132. Epub 2021 Jun 2.

Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China; Beijing Key Laboratory of Computational Intelligence and Intelligent System, Beijing University of Technology, Beijing 100124, China; Beijing Institute of Artificial Intelligence, Beijing University of Technology, Beijing 100124, China. Electronic address:

In this paper, we aim to solve the optimal tracking control problem for a class of nonaffine discrete-time systems with actuator saturation. First, a data-based neural identifier is constructed to learn the unknown system dynamics. Then, according to the expression of the trained neural identifier, we can obtain the steady control corresponding to the reference trajectory. Read More

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Insight into the pigmented anthocyanins and the major potential co-pigmented flavonoids in purple-coloured leaf teas.

Food Chem 2021 Jun 3;363:130278. Epub 2021 Jun 3.

Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. Electronic address:

Tea cultivars possessing purple shoots have attracted global interest. In order to gain a better understanding of the major chemical constituents responsible for the purple colouration, we applied widely targeted metabolomics to investigate the pigmented flavonoids of freeze-dried purple-coloured tea leaves (PTLs) in comparison with green-coloured tea leaves (GTLs). Thirty-three anthocyanins were identified, and delphinidin 3-O-galactoside and cyanidin 3-O-galactoside were found to be the most abundant in PTLs. Read More

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Establishing paediatric diagnostic reference levels using reference curves - A feasibility study including conventional and CT examinations.

Phys Med 2021 Jun 9;87:65-72. Epub 2021 Jun 9.

Department of Radiation Protection and Measurement Services, Norwegian Radiation and Nuclear Safety Authority, Bærum, Norway; Department of Health Sciences, Norwegian University of Science and Technology, Gjøvik, Norway.

Purpose: To derive Regional Diagnostic Reference Levels (RDRL) for paediatric conventional and CT examinations using weight-based DRL curves and compare the outcome with DRL derived using the weight groups.

Methods: Data from 1722 examinations performed at 29 hospitals in four countries were included. DRL was derived for four conventional x-ray (chest, abdomen, pelvis, hips/joints) and two types of CT examinations (thorax, abdomen). Read More

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In vitro tetraploidy induction creates enhancements in morphological, physiological and phytochemical characteristics in the fig tree (Ficus Carica L.).

Plant Physiol Biochem 2021 Jun 1;166:191-202. Epub 2021 Jun 1.

Department of Horticultural Science, College of Agriculture, Shiraz University, Shiraz, P.O. Box 65186-71441, Iran. Electronic address:

Fig tree (Ficus carica L.) is a precious fruit tree in semi-arid and arid areas worldwide which has difficulties in its conventional breeding programs. This study was carried out to make new genotypes with superior features based on the ploidy induction method. Read More

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Metagenomic insights into the effect of thermal hydrolysis pre-treatment on microbial community of an anaerobic digestion system.

Sci Total Environ 2021 Jun 1;791:148096. Epub 2021 Jun 1.

Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore. Electronic address:

Thermal hydrolysis process (THP) is an effective pre-treatment method to reduce solids volume and improve biogas production during anaerobic digestion (AD) via increasing the biodegradability of waste activated sludge (WAS). However, the effects of THP pre-treated sludge on microbial diversity, interspecies interactions, and metabolism in AD systems remain largely unknown. We therefore setup and operated an anaerobic digester during a long-term period to shed light on the effect of THP pre-treatment on AD microbial ecology in comparison to conventional AD via Illumina based 16S rRNA gene amplicon sequencing and genome-centric metagenomics analysis. Read More

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Comparison of indoor and outdoor oxidative potential of PM: pollution levels, temporal patterns, and key constituents.

Environ Int 2021 Jun 9;155:106684. Epub 2021 Jun 9.

School of Energy and Environment, Southeast University, Nanjing, China; Engineering Research Center of Building Equipment, Energy, and Environment, Ministry of Education, Nanjing, China.

Oxidative potential (OP) of PM is an emerging health indicator representing its ability to induce oxidative stress and cause adverse health effects. We examined pollution levels, temporal variations, and key constituents of PM OP by DTT assay in both indoor and outdoor environments in Nanjing, China, for over one year. Outdoor OP (mass-normalized OP characterizes toxicity) and OP (volume-based OP characterizes overall oxidative burden) in Nanjing were at a medium level compared to results reported for twenty-seven cities. Read More

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Music therapy enhances preterm infant's signs of engagement and sustains maternal singing in the NICU.

Infant Behav Dev 2021 Jun 9;64:101596. Epub 2021 Jun 9.

Psychology Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Hospitalized preterm infants are exposed to stressful stimuli and early parental separation, which can undermine their long-term development and mother-infant bonding. Family-centered music therapy can enable positive mother-infant interactions, mediated by maternal infant-directed singing. This study aimed to investigate the effects of music therapy on preterm infant's signs of engagement, namely Eye Opening (EO) and Smiling (SM), and maternal vocalizations. Read More

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The immunomodulatory effects of topiramate on azoxymethane-induced colon carcinogenesis in rats: The role of the inflammatory cascade, vascular endothelial growth factor, AKT/mTOR/MAP kinase signaling and the apoptotic markers.

Int Immunopharmacol 2021 Jun 9;98:107830. Epub 2021 Jun 9.

Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Background: Colon cancer is a malignant condition that affects the lower gastrointestinal tract and has unfavorable prognosis. Its mechanisms range from enhanced production of reactive oxygen species, inflammatory changes in the colon microenvironment and affection of the apoptotic pathways. Due to the high incidence of resistance of colon cancer to the traditional chemotherapeutic agents, a need for finding safe/effective agents that can attenuate the malignant changes had emerged. Read More

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Removal trend of amoxicillin and tetracycline during groundwater recharging reusing: Redox sensitivity and microbial community response.

Chemosphere 2021 Jun 4;282:131011. Epub 2021 Jun 4.

State Key Laboratory of Urban Water Resources and Environment (SKLUWRE); School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

The abundant existence of antibiotics within the effluent of wastewater treatment plant seriously threatened their safety recharging. To investigate the fate and biodegradation of those toxic antibiotics within the soil aquifer system, typical antibiotics of amoxicillin (AMX) and tetracycline (TC) were selected and their removal mechanisms were investigated. Experimental results revealed that totally 93. Read More

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Randomized trial of high-dose pyridoxine in combination with standard hormonal therapy in West syndrome.

Seizure 2021 May 29;91:75-80. Epub 2021 May 29.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective: To determine whether high-dose, oral pyridoxine in combination with standard adrenocorticotropic hormone (ACTH) therapy has superior effectiveness than ACTH therapy alone in increasing cessation of epileptic spasms for children with West syndrome.

Methods: This study was an open-label, randomized controlled trial with masked endpoint assessments. Eligible children with West syndrome, age ranged 3-18 months, were randomized into the intervention (n = 43) and the standard arm (n = 37) of therapy. Read More

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Robotic-assisted total knee arthroplasty improves the outlier of rotational alignment of the tibial prosthesis using 3DCT measurements.

Knee 2021 Jun 9;31:64-76. Epub 2021 Jun 9.

Department of Orthopedic Surgery, Toho University School of Medicine, Japan. Electronic address:

Background: The aim of the present study was to compare the accuracy of prosthetic alignment with three-dimensional computed tomography (3DCT) measurements following total knee arthroplasty (TKA) performed using a robotic-assisted surgical technique versus a conventional TKA.

Methods: 41 TKAs were performed with a handheld robotic-assisted surgical procedure (Robot group) between 2019 and 2020. Another 41 patients underwent TKA with a conventional manual surgical procedure (Manual group) using the same prosthesis. Read More

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Comparison of fixed dose versus train-of-four titration of cisatracurium in acute respiratory distress syndrome.

J Crit Care 2021 May 25;65:86-90. Epub 2021 May 25.

University of Kentucky HealthCare, Department of Pharmacy Services, United States of America; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, United States of America. Electronic address:

Purpose: To compare the ventilatory and clinical outcomes associated with a fixed-dose cisatracurium infusion versus a titrated infusion strategy in patients with Acute Respiratory Distress Syndrome (ARDS).

Materials And Methods: Single-center, retrospective, cohort study in a medical ICU of a tertiary care academic medical center. Adult patients ≥18 years old with a continuous infusion of cisatracurium for ≥12 h for treatment of ARDS were included. Read More

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Personalised Accelerometer Cut-point Prediction for Older Adults' Movement Behaviours using a Machine Learning approach.

Comput Methods Programs Biomed 2021 May 18;208:106165. Epub 2021 May 18.

Department of Computer Science, Edge Hill University, Ormskirk, L39 4QP, United Kingdom. Electronic address:

Background And Objectives: Body-worn accelerometers are the most popular method for objectively assessing physical activity in older adults. Many studies have developed generic accelerometer cut-points for defining activity intensity in metabolic equivalents for older adults. However, methodological diversity in current studies has led to a great deal of variation in the resulting cut-points, even when using data from the same accelerometer. Read More

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Rapid detection of colistin-resistant Enterobacterales using the resazurin reduction-based assay.

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor Darul Ehsan, Malaysia; Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, 840212, Sultan Abubakar Road, City Campus Complex, Sokoto State, Nigeria.

Objective: The emergence and dissemination of resistance determinants that confer colistin resistance among the Enterobacterales isolated from foods, animals, and humans create a serious public health problem due to the lack of remedial choices for infections caused by these isolates. This research aimed to evaluate the potential application of the resazurin reduction-based Rapid ResaPolymyxin NP assay in detecting the susceptibility of colistin in Enterobacterales .

Methods: Colistinsusceptibility test was performed by Rapid ResaPolymyxin NP technique and compared with reference broth microdilution method (BMD). Read More

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Host nutrition-based approach for biotechnological production of the antifungal cyclic lipopeptide jagaricin.

J Biotechnol 2021 Jun 9;336:1-9. Epub 2021 Jun 9.

Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Adolf-Reichwein-Str. 23, 07745, Jena, Germany. Electronic address:

In today's, society multi-resistant pathogens have become an emerging threat, which makes the search for novel anti-infectives more urgent than ever. A promising class of substances are cyclic lipopeptides like the antifungal jagaricin. Jagaricin is formed by the bacterial mushroom pathogen Janthinobacterium agaricidamnosum. Read More

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Barriers to and Facilitators of Sustained Employment: A Qualitative Study of Experiences in Dutch Patients With CKD.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Health Sciences, Applied Health Research, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Rationale & Objective: Although patients with chronic kidney disease (CKD) are at risk for work disability and work loss, not all experience work disruption. We aimed to describe the experienced barriers to and facilitators of sustained employment among Dutch patients with CKD.

Study Design: Qualitative study using semi-structured interviews. Read More

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A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays.

Clin Biochem 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Health System, Lebanon, NH, United States; he Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

Introduction: Commercially available serological assays for SARS-CoV-2 detect antibodies to either the nucleocapsid or spike protein. Here we compare the performance of the Beckman-Coulter SARS-CoV-2 spike IgG assay to that of the Abbott SARS-CoV-2 nucleocapsid IgG and Roche Anti-SARS-CoV-2 nucleocapsid total antibody assays. In addition, we document the trend in nucleocapsid and spike antibodies in sequential samples collected from convalescent plasma donors. Read More

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Small dense low-density lipoprotein: analytical review.

Clin Chim Acta 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical Biochemistry, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, Scotland, United Kingdom. Electronic address:

Background: The causal relationship between low-density lipoprotein (LDL) and atherosclerotic cardiovascular disease (CVD) has been firmly substantiated. LDL consists of a heterogeneous group of particles with different physicochemical and metabolic properties. Among them, small dense LDL (sdLDL) particles are considered an emerging CVD risk factor and a promising CVD risk biomarker. Read More

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A comparison of Prx- and OxyR-based HO probes expressed in S. cerevisiae.

J Biol Chem 2021 Jun 9:100866. Epub 2021 Jun 9.

German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

Genetically encoded fluorescent HO probes continue to advance the field of redox biology. Here we compare the previously established peroxiredoxin-based HO probe roGFP2-Tsa2ΔC with the newly described OxyR-based HO probe HyPer7, using yeast as the model system. While not as sensitive as roGFP2-Tsa2ΔC, HyPer7 is much improved relative to earlier HyPer versions, most notably by ratiometric pH stability. Read More

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Autotransporter-based surface expression and complementation of split TreA fragments utilized for the detection of antibodies against bovine leukemia virus.

J Immunol Methods 2021 Jun 9:113084. Epub 2021 Jun 9.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. Electronic address:

Bovine Leukemia Virus (BLV) is an oncogenic virus which is the etiological agent of a neoplastic disease in infected cattle called enzootic bovine leukemia (EBL). The most common and sensitive diagnostic methods for EBL like enzyme-linked immunosorbent assay (ELISA) is time-consuming and requires manual handling which makes it unsuitable as an on-farm diagnostic test. Hence, there is a need for an alternative test with rapid detection and reduced manual labour. Read More

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Clinico-microbiological description and evaluation of rapid lateral flow immunoassay and PCR for detection of Burkholderia pseudomallei from patients hospitalized with sepsis and pneumonia: A twenty-one months study from Odisha, India.

Acta Trop 2021 Jun 9:105994. Epub 2021 Jun 9.

Department of Community and Family Medicine, AIIMS, Bhubaneswar. Electronic address:

Establishing a diagnosis of melioidosis based on clinical grounds is difficult in hospitalized patients with sepsis or community acquired pneumonia (CAP). We aimed to ascertain the prevalence, clinico-epidemiological and laboratory profile of melioidosis in hospitalized patients with sepsis or CAP, and to evaluate the diagnostic utility of rapid lateral flow immunoassay (LFI) and PCR in comparison with culture. In all patients with sepsis or CAP, blood, sputum/throat swab, and urine sample were subjected to culture along with other samples based on clinical presentation. Read More

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Intra and peridomiciliary comparison of density, sex ratio and gonotrophic stage of Phlebotomus sergenti in an active anthroponotic cutaneous leishmaniasis focus in Morocco.

Acta Trop 2021 Jun 9:106005. Epub 2021 Jun 9.

Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.

Cutaneous leishmaniasis due to Leishmania tropica represents a major public health problem due to its ability to spread into non-endemic areas by means of its vectors, and the associated dramatic psychosocial impact. The objective of this work was to compare the intra and extradomiciliary density, sex ratio and gonotrophic stage of sand flies from a recent active focus in Morocco. This field study is based on the need to optimize the effectiveness of control programs. Read More

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Identifying counties at risk of high overdose mortality burden during the emerging fentanyl epidemic in the USA: a predictive statistical modelling study.

Lancet Public Health 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, University of California, San Diego, CA, USA.

Background: The emergence of fentanyl around 2013 represented a new, deadly stage of the opioid epidemic in the USA. We aimed to develop a statistical regression approach to identify counties at the highest risk of high overdose mortality in the subsequent years by predicting annual county-level overdose death rates across the contiguous USA and to validate our approach against observed overdose mortality data collected between 2013 and 2018.

Methods: We fit mixed-effects negative binomial regression models to predict overdose death rates in the subsequent year for 2013-18 for all contiguous state counties in the USA (ie, excluding Alaska and Hawaii). Read More

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Circulating microRNA profile in humans and mice with congenital GH deficiency.

Aging Cell 2021 Jun 12:e13420. Epub 2021 Jun 12.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.

Reduced inflammation, increased insulin sensitivity, and protection against cancer are shared between humans and mice with GH/IGF1 deficiency. Beyond hormone levels, miRNAs are important regulators of metabolic changes associated with healthy aging. We hypothesized that GH deficiency in humans alters the abundance of circulating miRNAs and that a subset of those miRNAs may overlap with those found in GH-deficient mice. Read More

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Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Trauma and Hand Surgery, Wroclaw Medical University, Poland.

Background: Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. Read More

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Effects of Apigenin on the Expression of LOX-1, Bcl-2, and Bax in Hyperlipidemia Rats.

Chem Biodivers 2021 Jun 12. Epub 2021 Jun 12.

Chengde Medical College: Chengde Medical University, Biochemistry, Anyuan Road, Chengde, CHINA.

We aimed to investigate the impact of apigenin on LOX-1, Bcl-2, and Bax expression in hyperlipidemia rats and explore the possible molecular pathological mechanism of apigenin in improving hyperlipidemia and preventing atherosclerosis. In hyperlipidemia models, the levels of TC, TG, LDL and the LOX-1 protein expression were apparently increased ( P <0.01), while the HDL levels and the ratio of Bcl-2/Bax were reduced significantly ( P <0. Read More

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Versatile Reaction Pathways of 1,1,3,3,3-pentafluoropropene at Rh(I) complexes [Rh(E)(PEt3)3] (E = H, GePh3, Si(OEt)3, F, Cl): C-F versus C-H Bond Activation Steps.

Chemistry 2021 Jun 12. Epub 2021 Jun 12.

Humboldt-Universitat zu Berlin, Department of Chemistry, GERMANY.

The reaction of the rhodium(I) complexes [Rh(E)(PEt 3 ) 3 ] (E = GePh 3 ( 1 ), H ( 6 ), F ( 7 )) with 1,1,3,3,3-pentafluoropropene afforded the defluorinative germylation products Z/E -2-(triphenylgermyl)-1,3,3,3-tetrafluoropropene and the fluorido complex [Rh(F)(CF 3 CHCF 2 )(PEt 3 ) 2 ] ( 2 ) together with the fluorophosphorane E -(CF 3 )CH=CF(PFEt 3 ). For [Rh(Si(OEt) 3 )(PEt 3 ) 3 ] ( 4 ) the coordination of the fluoroolefin was found  to give [Rh{Si(OEt) 3 }(CF 3 CHCF 2 )(PEt 3 ) 2 ] ( 5 ). Two equivalents of complex 2 reacted further by C-F bond oxidative addition to yield [Rh(CF=CHCF 3 )(PEt 3 ) 2 ( µ -F) 3 Rh(CF 3 CHCF 2 )(PEt 3 )] ( 9 ). Read More

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Inflammatory disease of the costotransverse joints: US evaluation in 15 symptomatic patients.

J Ultrasound 2021 Jun 12. Epub 2021 Jun 12.

Advanced Musculoskeletal Ultrasound, SIUMB School of Pisa, Pisa, Italy.

The costotransverse joints (CTJs) are small arthrodial joints which articulate with the costal tuberosity on the transverse process of the thoracic vertebrae. CTJs are composed of oval-shaped facets with a major axis, vertical at the upper vertebrae and almost horizontal at the lower vertebrae. This position explains the different movements of the ribs: the cranial ribs move on the sagittal plane and the caudal ribs on the transverse plane. Read More

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Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis.

Methods Mol Biol 2021 ;2275:173-186

Department of Pharmaceutical Sciences, College of Pharmacy-Glendale Campus, Midwestern University, Glendale, AZ, USA.

Creatine kinase (CK) enzyme overexpression has been suggested to play a role in the process of tumorigenesis and metastasis. Cyclocreatine (CCR) is a substrate analog of creatine kinase (CK), where its phosphorylated form is a poor phosphate donor in comparison with native bioenergetic molecule, creatine phosphate (Cr-P). The compound CCR has been shown to markedly inhibit the growth of a broad spectrum of cancers, both in vitro and in vivo. Read More

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January 2021