1,184 results match your criteria Comparison of Revascularization Procedures in Coronary Artery Disease


Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial.

Eur Heart J 2020 Jun 26. Epub 2020 Jun 26.

Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.

Aim: The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions.

Methods And Results: In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, including cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target lesion revascularization (TLR). Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa543DOI Listing

Gender differences in quality of life in coronary artery disease patients with comorbidities undergoing coronary revascularization.

PLoS One 2020 17;15(6):e0234543. Epub 2020 Jun 17.

Department of Cardiology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

In comparison to male patients with coronary artery disease, female patients suffer from more comorbidities, experience symptoms of coronary artery disease differently and report poorer health-related quality of life (HRQoL) after coronary revascularization. However, there is limited data on the impact of comorbidity burden on the recovery in HRQoL in female and male patients. We investigated the impact of comorbidity burden on the change in HRQoL following coronary revascularization in female patients versus male patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234543PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299316PMC

Endothelial progenitor cells predict long-term outcome in patients with coronary artery disease: Ten-year follow-up of the PROCREATION extended study.

Int J Cardiol 2020 Jun 6. Epub 2020 Jun 6.

Department of Cardiovascular Sciences, Sapienza University, Rome, Italy.

Background: Levels of circulating endothelial progenitor cells (EPCs) are associated with the short-term prognosis of patients with coronary artery disease (CAD). No previous study, however, has ascertained if EPCs are related also to long-term outcome. We performed a pre-specified analysis of the PROCREATION (PROgenitor Cells role in Restenosis and progression of coronary ATherosclerosis after percutaneous coronary intervention) study in order to assess if EPCs predict the 10-year prognosis. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.002DOI Listing

Comparison of Atherectomy to Balloon Angioplasty and Stenting for Isolated Femoropopliteal Revascularization.

Ann Vasc Surg 2020 Jun 5. Epub 2020 Jun 5.

Division of Vascular and Endovascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Introduction: The use of atherectomy for lower extremity revascularization is increasing despite concerning reports about its long-term safety and effectiveness. This study compares the outcomes of atherectomy to percutaneous transluminal angioplasty (PTA) and stenting for treatment of isolated femoropopliteal disease.

Methods: All patients undergoing endovascular treatment of isolated femoropopliteal lesions in the Vascular Quality Initiative (2009-2018) were identified. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.019DOI Listing

All Resting Physiological Indices May Not Be Equivalent - Comparison Between the Diastolic Pressure Ratio and Resting Full-Cycle Ratio.

Circ J 2020 Jun 4;84(7):1147-1154. Epub 2020 Jun 4.

Department of Cardiology, Tsuchiura Kyodo General Hospital.

Background: Differences between resting full-cycle ratio (RFR) and diastolic pressure ratio (dPR) have not been sufficiently discussed. This study aimed to investigate if there is a difference in diagnostic performance between RFR and dPR for the functional lesion assessment and to assess if there are specific characteristics for discordant revascularization decision-makings between RFR and dPR.Methods and Results:A total of 936 intermediate lesions in 776 patients who underwent measurements of fractional flow reserve (FFR), coronary flow reserve (CFR), and the index of microcirculatory resistance (IMR) were retrospectively studied. Read More

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http://dx.doi.org/10.1253/circj.CJ-19-1110DOI Listing

Comparison of myocardial blood flow and flow reserve with dobutamine and dipyridamole stress using rubidium-82 positron emission tomography.

J Nucl Cardiol 2020 May 24. Epub 2020 May 24.

University of Ottawa Heart Institute, University of Ottawa, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.

Background: The objective of this study was to compare the hyperemic myocardial blood flow (MBF) and myocardial flow reserve (MFR) obtained with dobutamine to those of dipyridamole in patients referred for myocardial perfusion imaging (MPI) using Rb positron emission tomography.

Methods: One hundred and fifty-six patients who underwent a Rb PET MPI study with dobutamine stress were included. A matching cohort of patients who underwent a Rb PET MPI study with dipyridamole stress was created, accounting for sex, age, history of coronary artery disease (CAD), prior revascularization, CAD risk factors, body mass index, and MPI interpretation. Read More

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http://dx.doi.org/10.1007/s12350-020-02186-1DOI Listing

Comparison of One-Year Outcomes in Patients >75 Versus ≤75 Years With Coronary Artery Disease Treated With COMBO Stents (From The MASCOT Registry).

Am J Cardiol 2020 Jul 24;127:1-8. Epub 2020 Apr 24.

Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA. Electronic address:

Older patients who undergo coronary interventions are at greater risk of ischemic events and less likely to tolerate prolonged dual antiplatelet therapy (DAPT) due to bleeding risk. The COMBO biodegradable polymer sirolimus-eluting stent promotes rapid endothelialization through endothelial progenitor cell capture technology which may be advantageous in elderly patients. We compared 1-year clinical outcomes and DAPT cessation events in patients >75 versus ≤75 years from the MASCOT registry. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.014DOI Listing
July 2020
3.276 Impact Factor

De novo malignancy risk in patients undergoing the first percutaneous coronary intervention: A nationwide population-based cohort study.

Int J Cardiol 2020 Aug 29;313:25-31. Epub 2020 Apr 29.

Department of Internal medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Background: Although percutaneous coronary intervention (PCI) has been the mainstay of revascularization strategy for significant coronary artery disease, future cancer risk after PCI has never been explored. We aimed to investigate the risk of incident cancer in patients undergoing PCI for the first time.

Methods: We studied 125,613 patients who underwent the first PCI between 2010 and 2015 without a prior history of cancer. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.085DOI Listing

Clinical prognosis associated with the use of overlapping stents with homogenous versus heterogeneous pharmacological characteristics for the treatment of diffuse coronary artery disease.

Cardiovasc Revasc Med 2020 Apr 24. Epub 2020 Apr 24.

Interventional Cardiology Unit, University General Hospital of Ciudad Real, Spain.

Background: The clinical impact of percutaneous coronary intervention (PCI) and implantation of overlapping stents (OS) using platforms with the same versus different pharmacological characteristics is unknown. Our objective was to compare the outcomes of PCI with OS according to their pharmacological characteristics.

Methods: In this observational single-center registry, we included all PCI performed from April 2014 to December 2018 in which overlapping drug-eluting stents were implanted. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.04.025DOI Listing

Coronary bifurcations treated with thin-strut drug-eluting stents: a prespecified analysis of the randomized comparison of biodegradable polymer and durable polymer drug-eluting stents in an all comers population trial.

Coron Artery Dis 2020 Apr 22. Epub 2020 Apr 22.

Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente.

Background: Treatment of a coronary bifurcation lesion is often required in routine clinical practice, but data on the performance of very thin-strut biodegradable polymer drug-eluting stents are scarce.

Methods: Comparison of biodegradable polymer and durable polymer drug-eluting stents in an all comers population (BIO-RESORT) is a prospective, multicenter randomized clinical trial that included 3514 all-comer patients, who were randomized to very thin-strut biodegradable polymer-coated sirolimus- or everolimus-eluting stents, versus thin-strut durable polymer-coated zotarolimus-eluting stents. The approach of bifurcation stenting was left at the operator's discretion, and provisional stenting was generally preferred. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000891DOI Listing

On-Pump vs Off-Pump coronary artery bypass surgery in atrial fibrillation. Analysis from the polish national registry of cardiac surgery procedures (KROK).

PLoS One 2020 22;15(4):e0231950. Epub 2020 Apr 22.

Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior, Centre of Postgraduate Medical Education, Warsaw, Poland.

Background: No single randomized study has ever before addressed the safety of On-Pump coronary artery bypass grafting (CABG) vs Off-Pump CABG in the setting of atrial fibrillation (AF) and data from small observational samples remain inconclusive.

Methods And Findings: Procedural data from KROK (Polish National Registry of Cardiac Surgery Procedures) were retrospectively collected. Of initial 188,972 patients undergoing CABG, 7,913 presented with baseline AF (76. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176119PMC

Long-Term (10-Year) Outcomes of Stenting or Bypass Surgery for Left Main Coronary Artery Disease in Patients With and Without Diabetes Mellitus.

J Am Heart Assoc 2020 Apr 20;9(8):e015372. Epub 2020 Apr 20.

Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.

Background Data are still limited regarding whether there are differential long-term outcomes after percutaneous coronary intervention versus coronary artery bypass grafting (CABG) for left main coronary artery disease with or without diabetes mellitus (DM). Methods and Results Using the 10-year data from the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) registry, we sought to examine the effect of DM on comparative outcomes after percutaneous coronary intervention or CABG in patients with unprotected left main coronary artery disease. The outcomes of interest were all-cause mortality; a composite of death, Q-wave myocardial infarction, or stroke; and target-vessel revascularization. Read More

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http://dx.doi.org/10.1161/JAHA.119.015372DOI Listing
April 2020
2.882 Impact Factor

Hypotheses, rationale, design, and methods for prognostic evaluation of a randomized comparison between patients with coronary artery disease associated with ischemic cardiomyopathy who undergo medical or surgical treatment: MASS-VI (HF).

Trials 2020 Apr 16;21(1):337. Epub 2020 Apr 16.

Instituto do Coraçao (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar 44, AB, Sala 114, Cerqueira César, São Paulo, SP, 05403-000, Brazil.

Background: Ischemic cardiomyopathy and severe left ventricular dysfunction are well established to represent the main determinants of poor survival and premature death compared with preserved ventricular function. However, the role of myocardial revascularization as a therapeutic alternative is not known to improve the long-term prognosis in this group of patients. This study will investigate whether myocardial revascularization contributes to a better prognosis for patients compared with those treated with drugs alone and followed over the long term. Read More

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http://dx.doi.org/10.1186/s13063-020-04270-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164251PMC

[Early and long-term outcomes of bilateral inthernal thoracic artery grafting for coronary artery bypass surgery].

Khirurgiia (Mosk) 2020 (3):74-81

Petrovsky Russian Research Center of Surgery, Moscow, Russia.

Objective: To evaluate safety of coronary artery bypass surgery using bilateral internal mammary artery and effectiveness of this procedure in long-term postoperative period.

Material And Methods: The study involved 129 patients who underwent CABG for the period 2006-2007. There were 2 groups of patients depending on surgical strategy: group 1 (n=61) - double IMA harvesting, group 2 (n=68) - CABG using single IMA. Read More

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http://dx.doi.org/10.17116/hirurgia202003174DOI Listing

Ten-Year Outcomes After Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Disease: Extended Follow-Up of the PRECOMBAT Trial.

Circulation 2020 May 30;141(18):1437-1446. Epub 2020 Mar 30.

Department of Cardiology (D.-W.P., J.-M.A., H.P, D.-Y.K., P.H.L., Y.-H.K., S.-J.P.), Asan Medical Center, Seoul, Korea.

Background: Long-term comparative outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents and coronary-artery bypass grafting (CABG) for left main coronary artery disease are highly debated.

Methods: In the PRECOMBAT trial (Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease), patients with unprotected left main coronary artery disease were randomly assigned to undergo PCI with sirolimus-eluting stents (n=300) or CABG (n=300) in 13 hospitals in Korea from April 2004 to August 2009. The follow-up was extended to at least 10 years for all patients (median, 11. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046039DOI Listing
May 2020
14.430 Impact Factor

Comparison of 9-Month Angiographic Follow-Up and Long-Term Clinical Outcomes of Biodegradable Polymer Drug-Eluting Stents and Second-Generation Durable Polymer Drug-Eluting Stents in Patients Undergoing Single Coronary Artery Stenting.

Acta Cardiol Sin 2020 Mar;36(2):97-104

Division of Cardiology, Department of Medicine and Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital; Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background: The durable polymers (DP) used in first-generation drug-eluting stents (DESs) were associated with long-term cardiovascular events, and thus biodegradable polymer DESs (BP-DESs) and second-generation DP-DESs were designed to overcome this problem. In this study, we compared angiographic follow-up and long-term clinical outcomes between patients who received BP-DESs or second-generation DP-DESs.

Methods: We enrolled 436 patients with single coronary lesions who received a second-generation DP-DES or BP-DES between June 2009 and October 2012. Read More

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http://dx.doi.org/10.6515/ACS.202003_36(2).20190729ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062815PMC
March 2020
0.845 Impact Factor

Comparison of coronary CT angiography versus functional imaging for CABG patients: A resource utilization analysis.

Int J Cardiol Heart Vasc 2020 Apr 5;27:100494. Epub 2020 Mar 5.

University of Ottawa Heart Institute, Division of Cardiology, Canada.

Aims: The impact of anatomical versus functional testing in patients with prior coronary artery bypass surgery (CABG) is poorly defined. We therefore sought to determine the rates of downstream investigations and the attendant healthcare costs in CABG patients undergoing CCTA versus SPECT.

Methods And Results: 2754 consecutive CABG patients were imaged by SPECT (2163) or CCTA (591). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063132PMC

Coronary Flow Velocity Reserve Reduction Is Associated with Cardiovascular, Cancer, and Noncancer, Noncardiovascular Mortality.

J Am Soc Echocardiogr 2020 May 12;33(5):594-603. Epub 2020 Mar 12.

Istituto Sant'anna, Pisa, Italy.

Background: Coronary flow velocity reserve (CFVR) measured in the left anterior descending artery during high-dose vasodilator stress echocardiography interrogates both epicardial and microcirculatory coronary function and has been inversely associated with chronic inflammation and microvascular dysfunction, as well as with the presence of obstructive coronary artery disease. Microvascular dysfunction and chronic inflammation are common mechanisms of disease in cardiovascular (CV) and non-CV conditions. We aimed to assess whether CFVR is associated with all-cause death, but more specifically with CV, cancer, and non-CV and noncancer (NCVNC) mortality, independently and increasingly over other demographic, clinical, and echocardiography variables. Read More

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http://dx.doi.org/10.1016/j.echo.2020.01.007DOI Listing

Randomized Comparison of Everolimus- and Zotarolimus-Eluting Coronary Stents With Biolimus-Eluting Stents in All-Comer Patients.

Circ Cardiovasc Interv 2020 Mar 12;13(3):e008525. Epub 2020 Mar 12.

Division of Cardiology, Dong-A University Hospital, Dong-A University, Busan, South Korea (M.-H.K.).

Background: There is limited data comparing the Xience everolimus-eluting stent (EES) and the Resolute zotarolimus-eluting stent (ZES) with the BioMatrix biolimus-eluting stent (BES).

Methods: This open-label, randomized, noninferiority trial enrolled all-comer patients to be randomly treated with either BES, EES, or ZES in a 1:1:1 ratio in 15 centers across South Korea. The primary end point was a device-oriented composite outcome consisting of cardiac death, target-vessel myocardial infarction, and clinically indicated target lesion revascularization at 24 months. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008525DOI Listing
March 2020
6.218 Impact Factor

Comparison of Machine Learning Computed Tomography-Based Fractional Flow Reserve and Coronary CT Angiography-Derived Plaque Characteristics with Invasive Resting Full-Cycle Ratio.

J Clin Med 2020 Mar 6;9(3). Epub 2020 Mar 6.

First Department of Medicine-Cardiology, University Medical Centre Mannheim, and DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Mannheim 68167, Germany.

Background: The aim is to compare the machine learning-based coronary-computed tomography fractional flow reserve (CT-FFR) and coronary-computed tomographic morphological plaque characteristics with the resting full-cycle ratio (RFR) as a novel invasive resting pressure-wire index for detecting hemodynamically significant coronary artery stenosis.

Methods: In our single center study, patients with coronary artery disease (CAD) who had a clinically indicated coronary computed tomography angiography (cCTA) and subsequent invasive coronary angiography (ICA) with pressure wire-measurement were included. On-site prototype CT-FFR software and on-site CT-plaque software were used to calculate the hemodynamic relevance of coronary stenosis. Read More

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http://dx.doi.org/10.3390/jcm9030714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141220PMC

Differential efficacy between stenting and plain balloon angioplasty for femoropopliteal disease with or without total occlusion.

Korean J Intern Med 2020 Feb 24. Epub 2020 Feb 24.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: Whether the presence of chronic total occlusion (CTO) affects patency after stenting in femoropopliteal lesions is unknown. We determined the effects of plain balloon angioplasty (POBA) in comparison with those of stenting on patency for femoropopliteal CTO and stenosis (non-CTO).

Methods: We analyzed data from the Korean Vascular Intervention Society Endovascular Therapy in Lower-Limb Artery Diseases Registry, a multicenter cohort of patients with lower extremity peripheral arterial disease. Read More

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http://dx.doi.org/10.3904/kjim.2019.039DOI Listing
February 2020

Rapid increase in hybrid surgery for the treatment of peripheral artery disease in the Vascular Quality Initiative database.

J Vasc Surg 2020 Feb 14. Epub 2020 Feb 14.

Section of Vascular and Endovascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn. Electronic address:

Objective: Advances in technology have increased the use of endovascular therapy for lower extremity revascularization (LER), but the impact on hybrid surgery has not been studied. This study aims to (1) investigate the contemporary national trends in frequency of hybrid LER and (2) compare the outcomes of open bypass (BYP) and hybrid surgery for isolated femoropopliteal revascularization.

Methods: Using the national Vascular Quality Initiative database from 2010 to 2017, all patients receiving bypass or hybrid LER for PAD were identified. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.11.041DOI Listing
February 2020

Concomitant carotid endarterectomy and cardiac surgery does not decrease postoperative stroke rates.

J Vasc Surg 2020 Feb 14. Epub 2020 Feb 14.

Department of Cardiac Surgery, Massachusetts General Hospital, Boston, Mass.

Objective: The timing of operative revascularization for patients with concomitant carotid artery stenosis and coronary artery disease remains controversial. We examined the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database to evaluate the association of combined carotid endarterectomy (CEA) and coronary artery bypass grafting (CABG) with postoperative outcomes.

Methods: All patients undergoing CABG with known carotid stenosis of >80% were identified from 2011 to 2016. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.10.072DOI Listing
February 2020

Comparison of Diagnostic Performance of Intracoronary Optical Coherence Tomography-based and Angiography-based Fractional Flow Reserve for Evaluation of Coronary Stenosis.

EuroIntervention 2020 Jan 21. Epub 2020 Jan 21.

Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Aims: To evaluate the diagnostic performance of OCT-based optical flow ratio (OFR) in unselected patients and compare it with angiography-based quantitative flow ratio (QFR), using wire-based FFR as reference standard.

Methods And Results: All patients with OCT and FFR assessment prior to revascularization were analyzed. OFR and QFR were computed in blinded fashion and compared with FFR, all applying same cut-off value of ≤0. Read More

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http://dx.doi.org/10.4244/EIJ-D-19-01034DOI Listing
January 2020

Long-Term Outcomes of Unprotected Left Main Coronary Artery Disease: Comparison of Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention.

J Invasive Cardiol 2020 Mar 15;32(3):111-116. Epub 2020 Jan 15.

Department of Cardiology, Dong-A University Hospital, 32 Daesingongwon-ro, Seo-gu, Busan, Republic of Korea, 602-714.

Objective: We compared the long-term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease in a real-world population.

Background: CABG is the standard of care for ULMCA disease. Contemporary randomized trials have reported conflicting results with the two revascularization strategies for the treatment of ULMCA disease at intermediate-term follow-up. Read More

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A comparison of immediate postoperative complications in using left internal mammary artery + vein versus only vein as conduit in patients undergoing off-pump coronary artery bypass grafting.

Ann Card Anaesth 2020 Jan-Mar;23(1):48-52

Department of Biochemistry, Himalayan Institute of Medical Sciences, SRH University, Dehradun, Uttarakhand, India.

Objective: The objective of the study is to compare the immediate postoperative cardiac complications in patients undergoing off-pump coronary artery bypass grafting (OPCABG) using mixed (arterial and venous grafts) versus only venous grafts and to compare the requirement of packed red cell units and intra-aortic balloon pump (IABP) in both the groups.

Materials And Methods: This was an observational, analytical, prospective study.

Sample Size: Fifty new patients were included in the study. Read More

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http://dx.doi.org/10.4103/aca.ACA_146_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034202PMC
January 2020

Randomized Comparison of Ridaforolimus-Eluting and Zotarolimus-Eluting Coronary Stents: 2-Year Clinical Outcomes From the BIONICS and NIREUS Trials.

JACC Cardiovasc Interv 2020 01;13(1):86-93

Piedmont Heart Institute, Atlanta, Georgia. Electronic address:

Objectives: This study sought to determine clinical outcomes between treatment groups over long-term follow-up.

Background: The safety and efficacy of a ridaforolimus-eluting stent (RES) was evaluated in the BIONICS (BioNIR Ridaforolimus-Eluting Coronary Stent System in Coronary Stenosis) and NIREUS (BioNIR Ridaforolimus Eluting Coronary Stent System [BioNIR] European Angiography Study) trials, demonstrating noninferiority of RES in comparison with a zotarolimus-eluting stent (ZES) regarding 1-year target lesion failure (TLF) and 6-month angiographic late lumen loss, respectively.

Methods: Patient-level data from the BIONICS (N = 1,919) and NIREUS (N = 302) randomized trials were pooled, and outcomes in patients implanted with RES and ZES compared. Read More

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http://dx.doi.org/10.1016/j.jcin.2019.08.019DOI Listing
January 2020

Clinical outcome comparison of percutaneous coronary intervention and bypass surgery in diabetic patients with coronary artery disease: a meta-analysis of randomized controlled trials and observational studies.

Diabetol Metab Syndr 2019 19;11:110. Epub 2019 Dec 19.

2Department of Cardiology, Tianjin Chest Hospital, Taierzhuang South Road No. 291, Jinnan District, Tianjin, 300350 China.

Background: The optimal revascularization technique in diabetic patients with complex coronary artery disease (CAD), including left main CAD and multivessel coronary disease (MVD), remains controversial. The current study aimed to compare adverse clinical endpoints of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in patients with diabetes mellitus (DM).

Methods: Relevant studies were found from MEDLINE, OVID, Science Direct, Embase and the Cochrane Central database from January 2010 to April 2019. Read More

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http://dx.doi.org/10.1186/s13098-019-0506-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923849PMC
December 2019

Comparison of Long-Term Clinical Outcome Between Multivessel Percutaneous Coronary Intervention Versus Infarct-Related Artery-Only Revascularization for Patients With ST-Segment-Elevation Myocardial Infarction With Cardiogenic Shock.

J Am Heart Assoc 2019 12 10;8(24):e013870. Epub 2019 Dec 10.

Division of Cardiology Department of Internal Medicine Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.

Background Data are limited regarding long-term outcomes in patients with ST-segment-elevation myocardial infarction and multivessel disease presenting with cardiogenic shock according to revascularization strategy. We sought to compare the 3-year clinical outcomes of patients with ST-segment-elevation myocardial infarction multivessel disease with cardiogenic shock and patients with multivessel percutaneous coronary intervention (PCI) and infarct-related artery (IRA)-only PCI. Methods and Results Of 13 104 patients from the nationwide, multicenter, prospective KAMIR-NIH (Korea Acute Myocardial Infarction Registry--National Institutes of Health) registry, we selected 659 patients with ST-segment-elevation myocardial infarction who had concomitant non-IRA stenosis and presented with cardiogenic shock. Read More

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http://dx.doi.org/10.1161/JAHA.119.013870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951086PMC
December 2019

Prognostic impact of diabetes mellitus and index of microcirculatory resistance in patients undergoing fractional flow reserve-guided revascularization.

Int J Cardiol 2020 May 5;307:171-175. Epub 2019 Nov 5.

Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China. Electronic address:

Background: The prognostic impact of diabetes mellitus (DM) with or without coronary microvascular dysfunction (CMD) in patients undergoing fractional flow reserve (FFR)-guided revascularization has not been clarified. We sought to investigate the clinical outcomes of patients undergoing FFR-guided revascularization according to the existence of DM and CMD.

Methods: A total of 283 patients with available FFR data as well as index of microcirculatory resistance (IMR) were selected from the 3 V FFR-FRIENDS study. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.10.040DOI Listing

Comparison of Three Atherosclerotic Cardiovascular Disease Risk Scores With and Without Coronary Calcium for Predicting Revascularization and Major Adverse Coronary Events in Symptomatic Patients Undergoing Positron Emission Tomography-Stress Testing.

Am J Cardiol 2020 02 6;125(3):341-348. Epub 2019 Nov 6.

Intermountain Medical Center, Intermountain Heart Institute, Salt Lake City, Utah; University of Utah, School of Medicine, Salt Lake City, Utah.

Atherosclerotic cardiovascular disease (ASCVD) is the most important cause of morbidity and mortality nationally and internationally. Improving ASCVD risk prediction is a high clinical priority. We sought to determine which of 3 ASCVD risk scores best predicts the need for revascularization and incident major adverse coronary events (MACE) in symptomatic patients at low-to-intermediate primary ASCVD risk referred for regadenoson-stress positron emission tomography (PET). Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.10.044DOI Listing
February 2020

Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry.

J Am Heart Assoc 2019 12 30;8(23):e013786. Epub 2019 Nov 30.

Department of Cardiology Hillel Yaffe Medical Center Hadera Israel.

Background Guidelines recommend heart team discussion and coronary artery bypass graft consideration in patients with proximal left anterior descending (LAD) artery stenosis. Evidence suggests that outcomes of proximal LAD angioplasty might not differ from treatment of nonproximal LAD locations. We aim to determine clinical outcomes of patients undergoing percutaneous coronary intervention in the proximal LAD segment in comparison with nonproximal LAD angioplasty, using a thin-strut drug-eluting stent. Read More

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http://dx.doi.org/10.1161/JAHA.119.013786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912975PMC
December 2019

Dedicated Bifurcation Stents for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials.

J Invasive Cardiol 2019 Dec;31(12):E344-E355

University Hospital, London Health Sciences Centre, 339 Windermere Road, N6A 5A5, London, Ontario, Canada.

Background: Percutaneous coronary intervention (PCI) of coronary bifurcation lesions (CBL) remains a challenge in contemporary practice due to the procedural and technical difficulties involved. We sought to review the current evidence on the safety and clinical outcomes of dedicated bifurcation stent (DBS) implantation in comparison with established treatment strategies for CBL-PCI.

Methods: We conducted a comprehensive search to identify randomized control trials (RCTs) reporting 1-year clinical and angiographic outcomes of patients undergoing CBL-PCI with DBS vs conventional CBL-PCI strategies. Read More

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December 2019
0.824 Impact Factor

Comparison of fractional myocardial mass, a vessel-specific myocardial mass-at-risk, with coronary angiographic scoring systems for predicting myocardial ischemia.

J Cardiovasc Comput Tomogr 2019 Nov 25. Epub 2019 Nov 25.

Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Emergency Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Aims: The burden of coronary artery disease has been assessed by various semi-quantitative angiographic scores, which are frequently different each other. A non-invasive and quantitative modality may substitute angiographic sores for prognostic implication and decision of revascularization strategy. We compared fractional myocardial mass (FMM) with angiographic scores for predicting myocardial ischemia. Read More

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http://dx.doi.org/10.1016/j.jcct.2019.11.001DOI Listing
November 2019

Presentation Pattern of Lower Extremity Endovascular Intervention versus Percutaneous Coronary Intervention.

J Atheroscler Thromb 2019 Nov 21. Epub 2019 Nov 21.

The Japanese Association of Cardiovascular Intervention and Therapeutics.

Aim: The aim of the current study is to describe the presentation pattern of symptomatic peripheral artery disease undergoing endovascular therapy (EVT) in comparison to symptomatic coronary artery disease undergoing percutaneous coronary intervention (PCI) based on data from nationwide databases.

Methods: Data were extracted from the nationwide procedural databases of EVT and PCI in Japan (J-EVT and J-PCI) between 2012 and 2017. The presentation pattern was investigated using a Poisson regression model, including the month, seasonality, and weekend (versus weekday) as the explanatory variables. Read More

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http://dx.doi.org/10.5551/jat.53330DOI Listing
November 2019

Poly (l-lactic acid) bioresorbable scaffolds versus metallic drug-eluting stents for the treatment of coronary artery disease: A meta-analysis of 11 randomized trials.

Catheter Cardiovasc Interv 2019 Nov 15. Epub 2019 Nov 15.

Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.

Background: Bioresorbable vascular scaffolds (BVS) have been proposed for overcoming the long-term limitations of permanent metallic stents, while theoretically warranting similar advantages in plaque stabilization and anti-restenotic drug delivery in the early postrevascularization phase. However, increased rates of malapposition, restenosis, or thrombosis have emerged from initial trials with BVS, that were nevertheless underpowered for the evaluation of the real outcome benefits of these coronary devices. The recent completion of newer randomized clinical trials paves the way to the present meta-analysis, aiming at the comparison of Poly (l-Lactic acid) BVS (PLLA-BVS) versus metallic drug-eluting stents (DES) in the treatment of coronary stenoses. Read More

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http://dx.doi.org/10.1002/ccd.28594DOI Listing
November 2019
3 Reads

Comparison of Short-Term Results between Patients Undergoing Coronary Artery Bypass Graft with a Stent-Placement History and Patients Undergoing Primary Coronary Artery Surgery.

J Tehran Heart Cent 2019 Apr;14(2):53-58

Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

: Percutaneous coronary intervention (PCI) has become the first-choice treatment strategy the world over for patients with chronic coronary artery disorders. This study compared the effects of previous PCI procedures on the short-term postoperative results of coronary artery bypass graft surgery (CABG). This cross-sectional analytical study recruited 220 patients who underwent CABG in Afshar Hospital in the Iranian city of Yazd between March 2009 and February 2013. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842022PMC

Comparison of Short and Long Term Cardiovascular Outcomes After Bariatric Surgery in Patients With vs Without Coronary Artery Disease.

Am J Cardiol 2020 01 10;125(1):40-47. Epub 2019 Oct 10.

Quebec Heart-Lung Institute, Quebec, Canada. Electronic address:

There is little data regarding the risks and benefits of bariatric surgery in patients with coronary artery disease (CAD). We aimed to assess the short- and long-term cardiovascular outcomes of patients with CAD undergoing bariatric surgery. Patients with a history of CAD were identified from a dedicated database with prospectively collected outcomes, comprising all 6795 patients who underwent bariatric surgery between January 1992 and October 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.09.041DOI Listing
January 2020
1 Read

Early and Mid-Term Vascular Responses to Optical Coherence Tomography-Guided Everolimus-Eluting Stent Implantation in Stable Coronary Artery Disease.

Can J Cardiol 2019 11 8;35(11):1513-1522. Epub 2019 Aug 8.

Iwate Medical University, Morioka, Japan.

Background: Analysis of pooled clinical data has shown the safety of 3 months of dual antiplatelet therapy with everolimus-eluting cobalt-chromium stents (Co-Cr EESs). This study evaluated early and mid-term vascular responses to Co-Cr EESs in patients with stable coronary artery disease.

Methods: The Multicenter Comparison of Early and Late Vascular Responses to Everolimus-Eluting Cobalt-Chromium Stent and Platelet Aggregation Studies in Patients With Stable Angina Managed as Elective Case (MECHANISM-Elective) study (NCT02014818) is a multicenter optical coherence tomography (OCT) registry. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.07.633DOI Listing
November 2019

Pulmonary Artery Acceleration Time in Young Adulthood and Cardiovascular Outcomes Later in Life: The Coronary Artery Risk Development in Young Adults Study.

J Am Soc Echocardiogr 2020 Jan 21;33(1):82-89.e1. Epub 2019 Oct 21.

Johns Hopkins University, Baltimore, Maryland. Electronic address:

Background: Lower pulmonary artery acceleration time (PAcT) is correlated with higher pulmonary artery pressure. The aim of this study was to test the hypothesis that PAcT measured in young adulthood would be associated with future cardiovascular outcomes.

Methods: In the Coronary Artery Risk Development in Young Adults year 5 examination (1990-1991), PAcT was measured as the time interval from onset to peak flow velocity at the pulmonary valve annulus on Doppler echocardiography. Read More

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http://dx.doi.org/10.1016/j.echo.2019.07.025DOI Listing
January 2020
1 Read

Bilateral internal thoracic artery grafting: propensity analysis of the left internal thoracic artery versus the right internal thoracic artery as a bypass graft to the left anterior descending artery.

Eur J Cardiothorac Surg 2020 Apr;57(4):701-708

Department of Cardiovascular Surgery, Nagoya Heart Center, Nagoya, Japan.

Objectives: To compare different configurations of the bilateral internal thoracic arteries for the left coronary system and examine early and late outcomes, including mid-term graft patency.

Methods: We reviewed 877 patients who underwent primary isolated coronary artery bypass grafting using in situ bilateral internal thoracic arteries [in situ right internal thoracic artery (RITA)-to-left anterior descending artery (LAD) grafting, n = 683; in situ left internal thoracic artery (LITA)-to-LAD grafting, n = 194]. We compared mid-term patency between the grafts. Read More

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http://dx.doi.org/10.1093/ejcts/ezz290DOI Listing
April 2020
1 Read

Comparison of efficacy and safety between ultrathin bioresorbable polymer sirolimus-eluting stents and thin durable polymer drug-eluting stents: a systematic review and meta-analysis of the literature.

Coron Artery Dis 2019 Dec;30(8):590-599

The Second Affiliated Hospital of Nanchang University, Bayi Avenue, Donghu district, Nanchang, China.

Objective: Ultrathin bioresorbable polymer sirolimus-eluting stents (BP SES) have been proposed as an alternative to thin durable polymer drug-eluting stents (DP DES). Although BP SES show a significant decrease in target lesion failure rates, clear superiority with respect to efficacy and safety of BP SES in comparison to DP EES has not been consistently proven.

Methods And Results: A comprehensive search of several electronic databases identified studies that assessed efficacy and safety of BP SES, compared with DP EES. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000797DOI Listing
December 2019
2 Reads

Comparison of SYNTAX Score I and SYNTAX Score II for Predicting Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery.

Heart Surg Forum 2019 Aug 27;22(5):E319-E324. Epub 2019 Aug 27.

Department of Cardiology, Haseki Training and Research Hospital, Istanbul, Turkey.

Background: Atrial fibrillation is a frequent cause of morbidity following coronary artery bypass grafting (CABG). SYNTAX score II (SSII) is associated with outcomes in patients undergoing coronary revascularization. We investigated the relationship between SSII and postoperative atrial fibrillation (POAF) in patients undergoing CABG. Read More

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http://dx.doi.org/10.1532/hsf.2495DOI Listing
August 2019
3 Reads

Clinical outcomes of patients with multivessel coronary artery disease treated with robot-assisted coronary artery bypass graft surgery versus one-stage percutaneous coronary intervention using drug-eluting stents.

Medicine (Baltimore) 2019 Sep;98(38):e17202

Cardiovascular Center, Taichung Veterans General Hospital, Taichung.

A number of studies have reported on treatment outcomes of coronary stenting (PCI) for multivessel coronary artery diseases (MVD), and compared them with the conventional coronary artery bypass grafting (CABG). However, the clinical outcomes of robot-assisted CABG (R-CABG) in comparison with PCI in MVD patients have not been investigated.We recruited retrospectively MVD patients receiving R-CABG and PCI with drug-eluting stents for all vessels in one stage between January 2005 and December 2013 at our institution with at least 3 years of outcomes were retrospectively recruited and analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000017202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756629PMC
September 2019
6 Reads

Treatment with a dedicated bifurcation sirolimus-eluting cobalt-chromium stent for distal left main coronary artery disease: rationale and design of the POLBOS LM study.

EuroIntervention 2019 Sep 24. Epub 2019 Sep 24.

Department of cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Aims: To demonstrate the noninferiority of the BiOSS LIM C sirolimus-eluting cobalt-chromium bifurcation dedicated stent against the Xience stent regarding patients oriented composite endpoint (POCE) at 12 months among patients with left main coronary artery disease (LMCA).

Methods And Results: The POLBOS LM study is a single-arm prospective multi-centre study enrolling 260 patients (SYNTAX score ≤32) with pre-specified performance goal based on the results of the EXCEL trial with contemporary percutaneous coronary intervention (PCI) for LMCA disease. Patient enrollment will comply with objective inclusion criteria of diameter stenosis ≥50% in LMCA based on off-line quantitative coronary angiography (QCA) analyzed by an independent core laboratory using dedicated-bifurcation QCA software. Read More

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http://dx.doi.org/10.4244/EIJ-D-19-00361DOI Listing
September 2019
3 Reads
3.769 Impact Factor

The Vascular Quality Initiative 30-day stroke/death risk score calculator after transfemoral carotid artery stenting.

J Vasc Surg 2020 Feb 13;71(2):526-534. Epub 2019 Sep 13.

Division of Vascular and Endovascular Surgery, University of California San Diego, San Diego, Calif. Electronic address:

Objective: Carotid artery stenting (CAS) was introduced as an alternative carotid revascularization procedure in patients deemed to be at high risk for carotid endarterectomy. Although techniques and selection criteria for patients have dramatically improved, CAS continues to have higher risk of stroke and death in comparison to carotid endarterectomy. Several risk factors are known to be associated with worse outcomes. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.05.051DOI Listing
February 2020
5 Reads

Comparison of the Effectiveness of Percutaneous Intervention of the Left-Main Coronary Artery With Everolimus-Eluting Stents in Women -Vs- Men.

Am J Cardiol 2019 11 16;124(9):1357-1362. Epub 2019 Aug 16.

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Everolimus-eluting stents are largely used for left main (LM) percutaneous coronary interventions (PCI). Long-term follow-up of patients who underwent LM PCI in a real world clinical setting, in particular women, have been scarcely reported. Consecutive patients who underwent unprotected LM PCI with EES at a single Institution from December 2006 to April 2016 were included. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.07.060DOI Listing
November 2019
3 Reads

Clinical outcomes of contemporary drug-eluting stents in patients with and without diabetes mellitus: Multigroup propensity-score analysis using data from stent-specific, multicenter, prospective registries.

Catheter Cardiovasc Interv 2019 Sep 3. Epub 2019 Sep 3.

Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Whether the diabetic status differentially affects the clinical outcomes with different drug-eluting stents (DES) has been controversial.

Methods And Results: From stent-specific, prospective DES registries, we evaluated 17,184 patients (11,428 in non-diabetics and 5,756 in diabetics) who received several contemporary DES: 3570 sirolimus-eluting stents (SES), 5,023 cobalt-chromium everolimus-eluting stents (CoCr-EES), 2,985 platinum-chromium EES (PtCr-EES), 2,913 Resolute zotarolimus-eluting stents (Re-ZES), and 2,693 biodegradable-polymer biolimus-eluting stents (BP-BES). The primary outcome was patient-oriented composite endpoint (POCE, a composite of all-cause death, any myocardial infarction, and any revascularization) at 3-year follow-up and target-vessel failure (a composite of cardiac death, target-vessel myocardial infarction, and target-vessel revascularization) at 3 years was also evaluated. Read More

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http://dx.doi.org/10.1002/ccd.28462DOI Listing
September 2019
3 Reads
2.107 Impact Factor

Comparison of a Complete Percutaneous versus Surgical Approach to Aortic Valve Replacement and Revascularization in Patients at Intermediate Surgical Risk: Results from the Randomized SURTAVI Trial.

Circulation 2019 Sep 3. Epub 2019 Sep 3.

Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: For patients with severe aortic stenosis (AS) and coronary artery disease (CAD), the completely percutaneous approach to aortic valve replacement and revascularization has not been compared to the standard surgical approach.

Methods: The prospective SURTAVI trial enrolled intermediate-risk patients with severe AS from 87 centers in the United States, Canada, and Europe between June 2012 and June 2016. Complex coronary artery disease with SYNTAX score >22 was an exclusion criterion. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039564DOI Listing
September 2019
5 Reads
14.430 Impact Factor

Comparison of drug-eluting balloon with repeat drug-eluting stent for recurrent drug-eluting stent in-stent restenosis.

Coron Artery Dis 2019 Nov;30(7):473-480

Cardiology Department, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, ROC.

Objective: Approximately, 10-20% of patients with drug eluting stent (DES) in-stent restenosis (ISR) will develop recurrent ISR; yet, the optimal management of recurrent DES-ISR is unknown. We sought to compare the outcomes of recurrent DES-ISR treated with drug eluting balloons (DEB) to those with repeated implantation of new-generation DES.

Methods: A total of 172 patients with recurrent DES-ISR were enrolled and stratified into two cohorts: the repeated DES implantation (Re-DES) group and the DEB group. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791562PMC
November 2019
4 Reads