2,050,173 results match your criteria Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics [Journal]


A selectivity study of benzenesulfonamide derivatives on human carbonic anhydrase II/IX by 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation.

Comput Biol Chem 2019 Apr 4;80:234-243. Epub 2019 Apr 4.

School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China; Chongqing Key Laboratory of Targeted Drug Screening and Activity Evaluation, Chongqing, 400054, China; Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing, 400054, China. Electronic address:

Nowadays, different approaches have been pursued with the intent to develop sulfonamide-like carbonic anhydrase inhibitors that possess better selectivity profiles toward the different human isoforms of the enzyme. Here, we used conventional 3D-QSAR methods, including comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and Topomer CoMFA, to construct three-dimensional quantitative structure-activity relationship (3D-QSAR) models for benzenesulfonamide derivatives as human carbonic anhydrase (hCA) II/IX inhibitors. The theoretical models had good reliability (R>0. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.005DOI Listing

Tip of the trichome: evolution of acylsugar metabolic diversity in Solanaceae.

Curr Opin Plant Biol 2019 Apr 19;49:8-16. Epub 2019 Apr 19.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Acylsugars are insecticidal plant specialized metabolites produced in the Solanaceae (nightshade family). Despite having simple constituents, these compounds are unusually structurally diverse. Their structural variations in phylogenetically closely related species enable comparative biochemical approaches to understand acylsugar biosynthesis and pathway diversification. Read More

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http://dx.doi.org/10.1016/j.pbi.2019.03.005DOI Listing

Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stress.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. Electronic address:

Sesame is one of the most important oilseed crops and has high nutritional value. The yield and quality of sesame are severely affected by high salinity in coastal and semi-arid/arid regions. In this study, the phenotypic, physiological, and proteomic changes induced by salt treatment were analyzed in salt-tolerant (G441) and salt-sensitive (G358) seedlings. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.017DOI Listing
April 2019
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Genome-wide annotation and comparative analysis of cuticular protein genes in the noctuid pest Spodoptera litura.

Insect Biochem Mol Biol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing, 400716, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400716, China. Electronic address:

Insect cuticle is considered an adaptable and versatile building material with roles in the construction and function of exoskeleton. Its physical properties are varied, as the biological requirements differ among diverse structures and change during the life cycle of the insect. Although the bulk of cuticle consists basically of cuticular proteins (CPs) associated with chitin, the degree of cuticular sclerotization is an important factor in determining its physical properties. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.012DOI Listing

Increased susceptibility to pertussis in adults at childbearing age as determined by comparative seroprevalence study, China 2010-2016.

J Infect 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Microbiology, Capital Medical University, Beijing, China; Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland. Electronic address:

Objectives: This study was aimed to determine pertussis specific serum PT-IgG antibodies in healthy individuals during 2010 and 2015/2016 in Beijing, China.

Methods: A total of 3884 healthy individuals were included: 3058 aged 3 to 69 years randomly selected from an epidemiological survey conducted in 2010, and 826 aged 20-39 years selected from those who attended an annual medical examination in 2015/2016. Serum PT-IgG antibodies were determined using the Serion/Virion ELISA kits. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.011DOI Listing

The sensilla trichodea-biased EoblPBP1 binds sex pheromones and green leaf volatiles in Ectropis obliqua Prout, a geometrid moth pest that uses Type-II sex pheromones.

J Insect Physiol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 310008, China. Electronic address:

Pheromone-binding proteins (PBPs) are considered to play critical roles in sex pheromone detection. Lepidopteran moths can be divided into two taxa, those that use Type-I sex pheromones, such as C10-C18 unsaturated aldehydes, alcohols and acetates, and those that use Type-II pheromones, which are C17-C23 polyunsaturated hydrocarbons and their epoxide derivatives. To date, nearly all the characterized PBPs have been reported in moths with Type-I sex pheromones, and the physiological functions of PBPs in moths that use Type-II sex pheromones remains unclear. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2019.04.005DOI Listing

Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis.

Gastrointest Endosc 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology, Beth Israel Deaconess Medical Center.

Background: Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating the quality of evidence using the GRADE system.

Methods: A systematic review of the literature in PubMed, EMBASE, and Web of Sciences was performed through April 2018. Read More

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http://dx.doi.org/10.1016/j.gie.2019.04.219DOI Listing

Refractive Laser-Assisted Cataract Surgery vs. Conventional Manual Surgery: Comparing Efficacy and Safety in 3144 Eyes.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Uptown Eye Specialists, Vaughan, Canada. Electronic address:

Purpose: To report on outcomes of efficacy and safety in one of the largest series of eyes undergoing either conventional manual cataract surgery (MCS) or refractive femtosecond laser-assisted cataract surgery (ReLACS).

Design: Retrospective, consecutive, interventional comparative case series.

Methods: This study included 3144 consecutive eyes of which 1580 were treated via MCS and 1564 were treated via ReLACS at Uptown Surgical Centre in Vaughan, Canada. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.010DOI Listing

A Comparative Study of The Electrospray Ionization Response of β-O-4' Lignin Model Compounds.

J Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry, University of Kentucky, Lexington, KY, 40506.

Electrospray ionization mass spectrometry has recently become the technique of choice for rapid characterization of lignin degradation products. However, the fundamental question of the relationship between lignin structure and ionization efficiency has not been explored. In this work, we studied the electrospray ionization response of five structurally similar β-O-4' model lignin compounds using lithium cationization in the positive electrospray ionization mode. Read More

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http://dx.doi.org/10.1002/jms.4365DOI Listing

Proteomics of intracellular Salmonella enterica reveals roles of Salmonella pathogenicity island 2 in metabolism and antioxidant defense.

PLoS Pathog 2019 Apr 22;15(4):e1007741. Epub 2019 Apr 22.

Abt. Mikrobiologie, Universität Osnabrück, Osnabrück, Germany.

Intracellular Salmonella enterica serovar Typhimurium (STM) deploy the Salmonella Pathogenicity Island 2-encoded type III secretion system (SPI2-T3SS) for the massive remodeling of the endosomal system for host cells. This activity results in formation of an extensive interconnected tubular network of Salmonella-induced filaments (SIFs) connected to the Salmonella-containing vacuole (SCV). Such network is absent in cells infected with SPI2-T3SS-deficient mutant strains such as ΔssaV. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007741DOI Listing

Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.

PLoS One 2019 22;14(4):e0215617. Epub 2019 Apr 22.

Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: C1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human studies have evaluated circulating levels of this adipokine in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, and coronary artery diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215617PLOS

Effects of Soft Toric, Rigid Gas-Permeable, and Mini-Scleral Lenses on Corneal Microstructure Using Confocal Microscopy.

Eye Contact Lens 2019 Apr 18. Epub 2019 Apr 18.

Cornea and Refractive Surgery Department (F.A., M.S., G.L., S.H.A., M.K.), Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; and Ophthalmic Research and Education Center (S.D.), Al Zahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Objective: To determine effects of wearing soft toric silicone hydrogel, rigid gas-permeable (RGP), and mini-scleral lenses on corneal microstructure using confocal microscopy.

Method: A prospective cohort study was conducted on 33 neophyte patients fitted with contact lenses (avg. age: 26±7 years) in the tertiary eye center. Read More

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http://Insights.ovid.com/crossref?an=00140068-900000000-9915
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http://dx.doi.org/10.1097/ICL.0000000000000612DOI Listing
April 2019
1 Read

Plant Proteome Databases and Bioinformatic Tools: An Expert Review and Comparative Insights.

OMICS 2019 Apr;23(4):190-206

1 Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

Historically, plant biology studies have lagged behind systems biology studies in animals and humans. However, there are signs of positive change as evidenced by the rise of big data in plant proteomics, and the availability of data science tools and next-generation sequencing technologies. Currently, the sequence information on nearly 300 plant species is available although they are curated to varying degrees of sophistication. Read More

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http://dx.doi.org/10.1089/omi.2019.0024DOI Listing

Analyses of Livestock-Associated Pan-Genomes Suggest Virulence Is Not Primary Interest in Evolution of Its Genome.

OMICS 2019 Apr;23(4):224-236

1 Department of Animal Behaviour & Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.

is not only part of normal flora but also an opportunistic pathogen relevant to microbial genomics, public health, and veterinary medicine. In addition to being a well-known human pathogen, causes various infections in economically important livestock animals such as cows, sheep, goats, and pigs. There are very few studies that have examined the pan-genome of or the host-specific strains' pan-genomes. Read More

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http://dx.doi.org/10.1089/omi.2019.0005DOI Listing

Expression and function of the bHLH genes ALCATRAZ and SPATULA in selected Solanaceae species.

Plant J 2019 Apr 22. Epub 2019 Apr 22.

Instituto de Biología, Universidad de Antioquia, Medellín, Colombia.

The genetic mechanisms underlying fruit development have been identified in Arabidopsis and have been comparatively studied in tomato as a representative of fleshy fruits. However comparative expression and functional analyses on the bHLH genes downstream the genetic network, ALCATRAZ (ALC) and SPATULA (SPT) which are involved in the formation of the dehiscence zone in Arabidopsis, have not been functionally studied in the Solanaceae. Here we perform detailed expression and functional studies of ALC/SPT homologs in Nicotiana obtusifolia with capsules, and Capsicum annuum and Solanum lycopersicum with berries. Read More

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http://dx.doi.org/10.1111/tpj.14352DOI Listing

Full-length mRNA sequencing and gene expression profiling reveal broad involvement of natural antisense transcript gene pairs in pepper development and response to stresses.

Plant J 2019 Apr 22. Epub 2019 Apr 22.

Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan, HB, China.

Pepper is an important vegetable with great economic value and unique biological features. In the past few years, significant development has been made towards understanding the huge complex pepper genome; however, pepper functional genomics has not been well studied. To better understand the pepper gene structure and pepper gene regulation, we conducted full-length mRNA sequencing by PacBio sequencing and obtained 57862 high-quality full-length mRNA sequences derived from 18362 previously annotated and 5769 newly detected genes. Read More

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http://dx.doi.org/10.1111/tpj.14351DOI Listing

A Comparative Analysis of the Safety Profile of Direct Oral Anticoagulants Using the FDA Adverse Event Reporting System.

Eur J Haematol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology, Oregon Health & Science University, Portland, OR.

Introductio: Direct oral anticoagulants (DOACs) are being increasingly used. However, unlike warfarin, less is known regarding their long-term side effects. To better evaluate the rates of DOAC-related adverse events (AEs) on a population level we examined AEs reported to the FDA for three commonly used DOACs and warfarin. Read More

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http://doi.wiley.com/10.1111/ejh.13240
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http://dx.doi.org/10.1111/ejh.13240DOI Listing
April 2019
4 Reads

Administration of enrofloxacin during late pregnancy failed to induce lesions in the resulting newborn foals.

Equine Vet J 2019 Apr 22. Epub 2019 Apr 22.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Background: A recent study demonstrated that enrofloxacin and ciprofloxacin cross the equine placenta without causing gross cartilage or tendon lesions in the 9-month foetus; however, long-term effects of in utero fluoroquinolone exposure are unknown.

Objectives: To assess effects of foetal exposure to enrofloxacin on the resulting foal's cartilage and tendon strength.

Study Design And Methods: Healthy mares at 280 days' gestation were allocated into four groups: untreated (n = 5), therapeutic treatment (7. Read More

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http://dx.doi.org/10.1111/evj.13131DOI Listing

Correlation Between Anterior Corneal Elevation Differences in Main Meridians and Corneal Astigmatism.

Eye Contact Lens 2019 Apr 15. Epub 2019 Apr 15.

Department of Optics II (Optometry and Vision) (L.B., G.C.), Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Clínica Oftalmológica Doctor Lens (L.B.), Madrid, Spain; Department of Optics, Pharmacology and Anatomy (D.P.), University of Alicante, Alicante, Spain; and Department of Ophthalmology (Oftalmar) (D.P.), Vithas Medimar International Hospital, Alicante, Spain.

Purpose: To assess the correlation between anterior corneal elevation (ACE) and anterior corneal astigmatism (ACA) obtained with two different topographers in healthy subjects at different corneal diameters.

Methods: A retrospective, comparative, and observational study was conducted. Topography data from 305 patients obtained with the Oculus Pentacam (Oculus, Wetzlar, Germany) and Sirius (CSO, Florence, Italy) systems were collected. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000613DOI Listing

Postvaccination Fever Response Rates in Children Derived Using the Fever Coach Mobile App: A Retrospective Observational Study.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e12223. Epub 2019 Apr 22.

Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Postvaccination fever is a mild adverse event that naturally improves without complications, but is highly prevalent and can be accompanied by febrile convulsions in some cases. These adverse effects may cause parents to delay or avoid vaccinating their children.

Objective: This study aimed to identify postvaccination fever patterns and the ability of antipyretics to affect changes in these patterns from data collected from a mobile app named Fever Coach. Read More

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http://dx.doi.org/10.2196/12223DOI Listing

Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure.

Int J Radiat Biol 2019 Apr 22:1-36. Epub 2019 Apr 22.

a Centro Regional de Ciências Nucleares do Nordeste (CRCN-NE) , 50740-545 , Recife , Brazil.

Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D + R) assays for dose assessment in cases of partial body irradiations (PBI).

Materials And Methods: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors were irradiated with 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1607606DOI Listing

Comparative observation of immediate and late placement of dental implants with immediate loading: A 14-year follow up case report.

J Oral Implantol 2019 Apr 22. Epub 2019 Apr 22.

4 Tufts University School of Dental Medicine.

A 63-year-old healthy female presented in 2002 for implant replacement of her maxillary right premolars following failure of a three-unit bridge replacing the second premolar. In a single appointment, the maxillary right first premolar was extracted and implants placed into the extraction socket and in the adjacent maxillary right second premolar healed site. Splinted interim restorations were inserted immediately after implant placement. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-18-00290DOI Listing

High contiguity whole genome sequence and gene annotation resource for two Venturia nashicola isolates.

Mol Plant Microbe Interact 2019 Apr 22. Epub 2019 Apr 22.

Pohang University of Science and Technology, 34995, Department of Life Sciences , 77 CheongAm-Ro , Nam-Gu , Pohang, GyeongBuk, Korea (the Republic of) , 37673 ;

Venturia nashicola is a fungal pathogen that causes Asian pear scab disease. This pathogen is of particular importance in Northeast Asian countries, where Asian pears are grown industrially. Scab disease in Asian pear is currently controlled by fungicide spraying and this situation calls for developing scab resistant cultivars. Read More

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http://dx.doi.org/10.1094/MPMI-03-19-0072-ADOI Listing

Efficacy and safety of long pulse 1064 and 2940 nm lasers in non-invasive lipolysis and skin tightening.

J Biophotonics 2019 Apr 22:e201900083. Epub 2019 Apr 22.

Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.

Background: Non-invasive body shaping is becoming a growing demand. The aim of this study was to investigate the efficacy and safety of the combined treatments of 1064nm Nd:YAG and 2940nm Er:YAG in non-invasive lipolysis and skin tightening.

Materials And Methods: 10 females were enrolled, all women's side of the waist or the lower part of the abdomen were treated. Read More

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http://dx.doi.org/10.1002/jbio.201900083DOI Listing

Ultrasonographic features of presumed gastric wall edema in 14 dogs with pancreatitis.

J Vet Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana.

Background: Gastric wall edema has not been reported as a complication of acute pancreatitis in dogs.

Objective: To describe the ultrasonographic features of gastric wall thickening in dogs with acute pancreatitis.

Animals: Fourteen dogs with ultrasonographic evidence and clinical diagnosis of acute pancreatitis, with ultrasonographic evidence of increased gastric wall thickness (>5 mm). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jvim.15507
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http://dx.doi.org/10.1111/jvim.15507DOI Listing
April 2019
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Functional performance of turtle humerus shape across an ecological adaptive landscape.

Evolution 2019 Apr 22. Epub 2019 Apr 22.

Museum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA, USA, 02138.

The concept of the adaptive landscape has been invaluable to evolutionary biologists for visualizing the dynamics of selection and adaptation, and is increasingly being used to study morpho-functional data. Here we construct adaptive landscapes to explore functional trade-offs associated with variation in humerus morphology among turtles adapted to three different locomotor environments: marine, semiaquatic, and terrestrial. Humerus shape from 40 species of cryptodire turtles was quantified using a pseudolandmark approach. Read More

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http://dx.doi.org/10.1111/evo.13747DOI Listing

Comparative genomics of 10 new species.

Evol Lett 2019 Apr 2;3(2):217-236. Epub 2019 Apr 2.

Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences University of Edinburgh Edinburgh EH9 3JT United Kingdom.

The nematode has been central to the understanding of metazoan biology. However, is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampling efforts have led to the discovery of over 50 putative species from the genus , many of which await formal species description. Read More

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http://dx.doi.org/10.1002/evl3.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457397PMC

Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity.

J Extracell Vesicles 2019 11;8(1):1597614. Epub 2019 Apr 11.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is a well-established poor prognostic marker for neuroblastoma. Whilst N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N-Myc in the aggressiveness of the disease is poorly understood. Read More

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http://dx.doi.org/10.1080/20013078.2019.1597614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461098PMC

Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

Comput Struct Biotechnol J 2019 26;17:447-453. Epub 2019 Mar 26.

Department of Haematology and Oncology, Medical University of Innsbruck, Austria.

In this review we aim to summarize studies investigating the impact of a molecular profiling (MP)-guided treatment approach in heavily pretreated cancer patients. In summary, many independent single- and multicenter studies showed a significant benefit of MP-guided treatment regarding response rates and survival. However, in the only randomized trial conducted so far, no benefit of MP-guided targeted therapy was observed. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453774PMC

Bone Level Measurements Around Platform Switched and Platform Matched Implants: A Comparative Study.

Niger J Surg 2019 Jan-Jun;25(1):9-13

Department of Prosthodontics, Crown and Bridge, Yogita Dental College, Khed, Rantagiri, India.

Background: The overall success of dental implants depends on the crestal bone support around the implants. During the initial years, the bone loss around the implants determines the success rate of treatment. Platform switching (PLS) preserves the crestal bone loss, and this approach must be applied clinically. Read More

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http://www.nigerianjsurg.com/text.asp?2019/25/1/9/248493
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http://dx.doi.org/10.4103/njs.NJS_19_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452768PMC
April 2019
1 Read

Evaluation of mandibular anterior nutrient canals in hypertensive and diabetes mellitus patients: A comparative radiographic study.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;31(2):118-123

Department of Oral Medicine and Radiology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India.

Objective: Radiographic evaluation of nutrient canals (NCs) in the mandibular anterior region using intraoral periapical radiographs (IOPARs) and to determine whether they can be used as a potential marker for hypertension (HT) and diabetes mellitus (DM).

Materials And Methods: Randomly selected 600 patients of 21-60 years age group (Group I: 200 HT; Group II: 200 DM; Group III: Healthy subjects) were considered. The case history was recorded including details for DM and HT (duration, type, and medication). Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_43_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450156PMC

Comparative Study between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Male: A Randomized Controlled Trial.

Int J Trichology 2019 Mar-Apr;11(2):58-67

Department of Dermatology, Government Medical College, Bhavnagar, Gujarat, India.

Aim: This study aims to compare efficacy and safety between mesotherapy (intralesional injection) and 5% topical minoxidil solution in male androgenic alopecia (AGA) by dermoscopic evaluation.

Methodology: In a randomized active controlled trial, we enrolled 49 clinically diagnosed males of AGA and randomly allotted them into two groups - mesotherapy (A) (25) and minoxidil (B) (24). Males in Group A were given total 8 sessions of intralesional mesosolution with microneedling procedure while Group B males were prescribed topical solution of minoxidil 5% twice daily for 4 months. Read More

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http://dx.doi.org/10.4103/ijt.ijt_89_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463458PMC

A comparative in vitro study of standard facemask jet nebulization and high-flow nebulization in bronchiolitis.

Exp Lung Res 2019 Apr 22:1-9. Epub 2019 Apr 22.

c Chemical Engineering Division, Department of Biotechnology and Food Science , Universidad de Burgos , Burgos , Spain.

Aim Of Study: The use of a nebulizer paired with high-flow nasal cannulas (HFNC) has been proposed for drug delivery in bronchiolitis. Particle size nebulized is a relevant factor determining the efficacy of the nebulization. We replicated in vitro the theoretical parameters most widely used in bronchiolitis and we compared the size of the droplet nebulized with a standard nebulizer and a nebulizer integrated into HFNC. Read More

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https://www.tandfonline.com/doi/full/10.1080/01902148.2019.1
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http://dx.doi.org/10.1080/01902148.2019.1599084DOI Listing
April 2019
1 Read

Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1428-1436

c School of Pharmacy , University of the Western Cape , Bellville , South Africa.

Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and compared their capability to enhance pentamidine penetration across blood brain barrier (BBB). Size, polydispersity index, zeta potential, morphology, pentamidine loading and drug release profiles were determined by various methods. Read More

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http://dx.doi.org/10.1080/21691401.2019.1596923DOI Listing
December 2019

Establishment of three-dimensional canine osteosarcoma cell lines showing vasculogenic mimicry and evaluation of biological properties after treatment with 17-AAG.

Vet Comp Oncol 2019 Apr 21. Epub 2019 Apr 21.

Faculty of Veterinary Medicine, University of Teramo, Teramo (TE), Italy.

Vasculogenic mimicry (VM) is an alternative type of blood perfusion characterized by formation of non-endothelial cell-lined microcirculatory channels and is responsible for aggressive tumor biology and increased tumor-related mortality. VM-correlated genes are associated with vascular endothelial grown factor receptor 1 (VEGFR1), and hypoxia-related (hypoxia inducible factor 1 α - HIF1α) signaling pathways, whose molecules are client proteins of Hsp90 (Heat shock protein 90) and are potential therapeutic targets. This pilot study was aimed to investigate vasculogenic mimicry in a three-dimensional (3D) cell culture system of two aggressive canine osteosarcoma (OSA) cell lines (D22 and D17), and to evaluate the response of these cells to 17-AAG treatment in relation to tubular-like structure formation in vitro. Read More

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http://dx.doi.org/10.1111/vco.12482DOI Listing

The role of oclacitinib in the management of ischaemic dermatopathy in four dogs.

Vet Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Ischaemic dermatopathy represents a heterogenous and poorly-characterized canine syndrome that is often refractory to conventional immunosuppression. Janus-kinase inhibitors (JAKinibs) are used for the treatment of various human autoimmune diseases, including dermatomyositis. Oclacitinib is a generally well-tolerated, veterinary-approved, nonselective JAKinib that has therapeutic potential as an immunosuppressant. Read More

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http://dx.doi.org/10.1111/vde.12743DOI Listing

[The significance of the dynamics of anxiety-depressive indicators and quality of life in patients with dental anomalies in assessing the effectiveness of orthodontic treatment].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):88-92

Evdokimov Moscow State University of Medicine and Dentisty, Moscow, Russia.

Aim: To study the dynamics of clinical and psychological characteristics and indicators of quality of life in patients with dental-maxillary anomalies.

Material And Methods: Seventy people with different dental anomalies were studied. At the first stage, all patients were assessed according to the developed 'Smile Aesthetics Index' (SAI) with their further division into three subgroups depending on the severity of dentofacial anomalies. Read More

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http://dx.doi.org/10.17116/jnevro20191191288DOI Listing
January 2019

[Comparative assessment of the expression of Muc 2, Muc 5AC, and Muc 6 in serrated neoplasms of the colon].

Arkh Patol 2019 ;81(2):10-17

Research Institute of Human Morphology, Moscow, Russia.

In the course of the serrated pathway of carcinogenesis, there are changes in the expression of mucins with a characteristic immunophenotypic sign, such as a late loss of intestinal differentiation and an increase in gastric differentiation.

Objective: To comparatively assess the expression of Muc 2, Muc 5AC, and Muc 6 in hyperplastic polyps (HPs), sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) of the colon for determination of their role in differential diagnosis.

Material And Methods: Sixty-five serrated masses from 52 patients were examined. Read More

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http://dx.doi.org/10.17116/patol20198102110DOI Listing
January 2019
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Relative Effect of Current Intensive Lipid-Lowering Drugs on Cardiovascular Outcomes in Secondary Prevention - A Meta-Analysis of 12 Randomized Trials.

Circ J 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University.

Background: We aimed to investigate the comparative cardiovascular benefits of high-dose statin, ezetimibe-statin, and PCSK9 inhibitor-statin treatments in secondary prevention patients.Methods and Results:We selected 12 randomized controlled trials (n=131,978 patients) using PubMed and Embase (inception-June 1, 2018). Subgroup differences were explored by meta-regression and Cochran Q test. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1321DOI Listing

Memory Performance Influences Male Reproductive Success in a Wild Bird.

Curr Biol 2019 Apr 2. Epub 2019 Apr 2.

School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.

Despite decades of comparative research, how selection shapes the evolution of cognitive traits remains poorly understood [1-3]. Several lines of evidence suggest that natural selection acts on spatial memory in food-caching species [3-6]. However, a link between reproductive fitness and spatial memory ability has yet to be demonstrated in any caching species [1, 3, 6]. Read More

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http://dx.doi.org/10.1016/j.cub.2019.03.027DOI Listing

CCR4-NOT transcription complex, subunit 1 (CNOT1) Variant Associated with Holoprosencephaly.

Am J Hum Genet 2019 Apr 5. Epub 2019 Apr 5.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Holoprosencephaly is the incomplete separation of the forebrain during embryogenesis. Both genetic and environmental etiologies have been determined for holoprosencephaly; however, a genetic etiology is not found in most cases. In this report, we present two unrelated individuals with semilobar holoprosencephaly who have the identical de novo missense variant in the gene CCR4-NOT transcription complex, subunit 1 (CNOT1). Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.03.017DOI Listing

Contribution of Sensory Processing to Chronic Constipation in Preschool Children.

J Pediatr 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, IL; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

Objective: To assess differences in sensory processing patterns between children with chronic constipation compared with a matched normative sample as well as to examine the extent to which specific sensory processing patterns and modality scores predicted atypical toileting behaviors.

Study Design: We used a cross-sectional comparative design to evaluate differences between children age 3 and 5 years old with constipation (n = 66) and those in a matched control sample (n = 66). We also examined the contribution of sensory processing patterns to atypical toileting behavior in the clinical sample. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.03.020DOI Listing

Statistical physics of liquid brains.

Philos Trans R Soc Lond B Biol Sci 2019 Jun;374(1774):20180376

1 ICREA-Complex Systems Lab, Universitat Pompeu Fabra , 08003 Barcelona , Spain.

Liquid neural networks (or 'liquid brains') are a widespread class of cognitive living networks characterized by a common feature: the agents (ants or immune cells, for example) move in space. Thus, no fixed, long-term agent-agent connections are maintained, in contrast with standard neural systems. How is this class of systems capable of displaying cognitive abilities, from learning to decision-making? In this paper, the collective dynamics, memory and learning properties of liquid brains is explored under the perspective of statistical physics. Read More

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http://dx.doi.org/10.1098/rstb.2018.0376DOI Listing

Examining the relevance of employment integration policies on disability benefit receipt: a multilevel analysis of older working age adults in 16 countries.

Authors:
Zachary A Morris

Disabil Rehabil 2019 Apr 21:1-9. Epub 2019 Apr 21.

a School of Social Welfare , Stony Brook University , Stony Brook , NY , USA.

Purpose: Nearly all advanced economic countries have adopted employment integration policies to improve the labor market outcomes of workers with disabilities and to reduce enrollment on disability benefits. To date, research has yet to investigate whether the adoption of integration policies is associated with a reduced likelihood of an older working age adult receiving disability benefits.

Materials And Methods: This study, drawing on data of older working-age adults from the Survey of Health Ageing and Retirement in Europe, the English Longitudinal Study of Ageing, and the Health and Retirement Study, applies multilevel logistic regression to investigate the relationship between country-level integration policies and the likelihood of disability benefit receipt in 16 OECD countries. Read More

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http://dx.doi.org/10.1080/09638288.2019.1593521DOI Listing

Ankle Arthrodesis With Structural Grafts Can Work for the Salvage of Failed Total Ankle Arthroplasty.

Foot Ankle Spec 2019 Apr 22:1938640019843317. Epub 2019 Apr 22.

Orthopaedic Foot and Ankle Center, Westerville, Ohio.

Background: Treatment options after failed total ankle arthroplasty (TAA) are limited. This study reports midterm outcomes and radiographic results in a single-surgeon group of patients who have undergone ankle arthrodesis with intramedullary nail fixation and structural allograft augmentation following failed TAA.

Methods: A retrospective review on patients who underwent failed TAA revision with structural femoral head allograft and intramedullary tibiotalocalcaneal (TTC) nail fixation was completed. Read More

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http://dx.doi.org/10.1177/1938640019843317DOI Listing

[Comparative evaluation of preoperation transcatheter arterial chemoembolization in children with advanced wilms tumor].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1147-1151

Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

To evaluate the therapeutic effect and prognosis of preoperative transcatheter arterial chemoembolization (TACE), transcatheter arterial chemoembolization (TAIC), preoperative intravenous chemotherapy for children with advanced stage nephroblastoma. From January 2007 to December 2018, according to different treatment protocols before surgery, children with nephroblastoma were divided into 3 groups, which were TACE group (44 cases), TAIC group (7 cases) and intravenous chemotherapy group (9 cases) in Children's Hospital, Zhejiang University School of Medicine. The imaging examination, treatment safety and long-term efficacy of these three groups before and after treatment were compared. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.006DOI Listing

Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the packages for R and Python.

F1000Res 2019 10;8:42. Epub 2019 Jan 10.

Centre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK.

The Orthologous Matrix (OMA) is a well-established resource to identify orthologs among many genomes. Here, we present two recent additions to its programmatic interface, namely a REST API, and user-friendly R and Python packages called . These should further facilitate the incorporation of OMA data into computational scripts and pipelines. Read More

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http://dx.doi.org/10.12688/f1000research.17548.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464060.2PMC
January 2019

Clomiphene citrate and neural tube defects: a meta-analysis of controlled observational studies.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, France.

Background: At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0. Read More

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http://dx.doi.org/10.1111/1471-0528.15800DOI Listing

Oral premalignant lesions of smokers and non-smokers show similar carcinogenic pathways and outcomes. A clinicopathological and molecular comparative analysis.

J Oral Pathol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Pathology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain.

Background: Oral premalignant lesions (OPML) are frequently extensive and multifocal leading high morbidity for patients. Although oral squamous carcinoma (OSCC) in non-smoker patients is increasing, little is known about OPML and the carcinogenesis process in these patients. The aims of the study were to insight and compare the clinicopathological and molecular characteristics of OPML of non-smoker and smoker patients from which one or multiple OSCC have developed. Read More

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http://dx.doi.org/10.1111/jop.12864DOI Listing

Oral allergen immunotherapy by targeting Peyer's patches.

Allergy 2019 Apr 21. Epub 2019 Apr 21.

Comparative Medicine, The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Veterinärplatz 1, A-1210, Vienna, Austria.

The present patent relates to the use of bioadhesive, biodegradable poly-lacto-glycolic (PLGA) microparticles for allergen immunotherapy. Surface modification of allergen-loaded microspheres with Aleuria aurantia lectin causes selective enrichment, prolongation of the dwell time and uptake via mucosal M cells overlying the lymph nodes e.g. Read More

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http://dx.doi.org/10.1111/all.13828DOI Listing
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