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Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Biological, Geological and Environmental Sciences, University of Bologna, via S. Alberto 163, 48123 Ravenna, Italy.

The emerging paradigm on plastic pollution in marine environments is that microsize particles (MPs) have far more subtle effects than bigger fragments, given their size range overlapping with that of particles ingested by filter-feeders. The impacts include gut blockage, altered feeding and energy allocation, with knock-on effects on widespread physiological processes. This study investigated whether ingestion of polystyrene MPs (PS-MPs) triggers protective processes in marine mussels. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

The progressive growth of aquaculture implicates a dependence on large water amounts, which are submitted to disinfection processes, namely ozonation. Considering the importance of genomic integrity, it is critical to improve the knowledge on ozone-related genotoxic hazard to organisms reared in recirculating aquaculture systems (RAS) applying ozonation. Therefore, genetic damage induced by ozone exposure in the Senegalese sole (Solea senegalensis) was assessed, combining the comet and the erythrocytic nuclear abnormalities (ENA) assays, reflecting different damage levels, i. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 10;219:42-49. Epub 2019 Feb 10.

Unilasalle-Universidade Lassalle, Mestrado de Avaliação em Impactos Ambientais, Av. Victor Barreto, 2288, CEP 92010-000 Canoas, RS, Brazil.

This study aims to evaluate the contamination of the water of Lagoa Tramandaí on Genidens genidens and Citharichthys spilopterus residents of Lagoa Tramandaí, a region susceptible to environmental damage due to the release of domestic sewage from the municipalities bathed by the lagoon. Thereby, the biota suffers the interference of heavy metals, affecting their behavior and the metabolism of these individuals. The hepatic and muscular glycogen, glucose and plasma lactate of these species were analyzed, as well as the presence of heavy metals in lagoon water. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Ministry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, Haikou, China. Electronic address:

The red-eared slider (Trachemys scripta elegans), a freshwater turtle, is an invasive species in many parts of the world where it survives in both freshwater and coastal saline habitats. High salinity can induce reactive oxygen species (ROS) production and lead to oxidative damage. In this study, we investigate the antioxidant defense mechanisms of T. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 6;219:25-34. Epub 2019 Feb 6.

Fishery Machinery and Instrument Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200092, China.

The present study was to investigate the effects of stocking density on the welfare of juvenile Chinese sturgeon (Acipenser sinensis) cultured in a recirculating aquaculture system (RAS) for three months. Fish (average weight 760.86 g) were reared in triplicate under three densities: low density (4. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 6;219:35-41. Epub 2019 Feb 6.

University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA.

Acute exposure to crude oil and polycyclic aromatic hydrocarbons (PAH) can severely impair cardiorespiratory function and swim performance of larval, juvenile and adult fish. Interestingly, recent work has documented an oil induced decoupling of swim performance (U) and maximum metabolic rate (MMR) whereby oil causes a decline in U without a parallel reduction in MMR. We hypothesize that this uncoupling is due to impaired mitochondrial function in swimming muscles that results in increased proton leak, and thus less ATP generated per unit oxygen. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 2;219:12-24. Epub 2019 Feb 2.

Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

DNA integrity and stability are essential to organisms' health and survival. However, it has been neglected in what concerns to fish farming, disregarding the potential impact of endogenous/ exogenous factors. As marine macroalgae constitute a source of natural compounds with a large spectrum of biological activities, this study, situated in the interface of nutritional-genetic research and development of algae practical applications, aimed to evaluate the genoprotective properties of a macroalgae-enriched diet (total percentage of 5%, incorporating equal percentages of Ulva rigida, Gracilaria gracilis and Fucus vesiculosus) in gilthead seabream (Sparus aurata). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 25;219:1-11. Epub 2019 Jan 25.

Department of Chemistry, Montréal University, Montréal, QC H2V 2B8, Canada.

The release of engineered nanoparticles in the aquatic environment could pose a threat to the biota. The purpose of the study was to examine the influence of surface water characteristics on zinc oxide nanoparticles (nZnO) and ZnS0 toxicity to the freshwater mussel Dreissena polymorpha. Mussels were exposed to an equivalent concentration of 25 μg/L Zn as either nZnO or ZnSO for 96 h at 15 °C in 4 types of surface waters: green water (high conductivity and pH with low natural organic matter content), brown water (low conductivity and pH with high natural organic matter content), diluted municipal effluent (high conductivity and pH with high urban organic matter content) and aquarium water (treated green water with organic matter removed). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 17;218:81-87. Epub 2019 Jan 17.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 194223 Saint-Petersburg, Russia. Electronic address:

Previously we showed that arginine-vasotocin (AVT)-stimulated osmotic water permeability (OWP) of the frog urinary bladder was decreased if the mucosal side of the bladder has been naturally colonized by Gram-negative bacteria, or if bacterial lipopolysaccharide (LPS) was introduced into the lumen of the isolated bladder (J. Exp. Zool. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 15;218:88-95. Epub 2019 Jan 15.

Developmental and Integrative Biology Division, Department of Biological Sciences, University of North Texas, Denton, TX 76203, United States. Electronic address:

Mitochondrial function is critical to support aerobic metabolism through the production of ATP, and deficiencies in mitochondrial bioenergetics will directly impact the performance capacity of highly aerobic tissues such as the myocardium. Cardiac function in fish has been shown to be negatively affected by crude oil exposure, however, the mechanism for this adverse response is largely unexplored. We hypothesized that lipophilic polycyclic aromatic hydrocarbons (PAHs) found in crude oil disrupt the electron transport system (ETS) ultimately leading to mitochondrial dysfunction. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 15;218:70-80. Epub 2019 Jan 15.

Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.

Analyzing effects of metal mixtures is important to obtain a realistic understanding of the impact of mixed stress in natural ecosystems. The impact of a one-week exposure to a sublethal metal mixture containing copper (4.8 μg/L), cadmium (2. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 11;218:62-69. Epub 2019 Jan 11.

Department of Fisheries, Faculty of Natural Resources, University of Kurdistan, Sanandaj, Iran. Electronic address:

This study evaluated the potential toxic effects of silver nanoparticles (AgNPs) and silver nanowires (AgNWs) on saltwater microcrustacean Artemia salina nauplii under ISO TS 20787 guideline. To investigate the acute toxicity of these nanomaterials, the nauplii were exposed to different concentrations of 0 (control), 0.39, 1. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 27;218:36-45. Epub 2018 Dec 27.

Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India. Electronic address:

Sea weeds are valuable natural assets in aquaculture due to the presence of various bioactive active metabolites in them. Successful fish production and maintenance of disease free culturing systems in aquaculture with environment friendly practices is often affected by various environmental factors. Disease causing pathogens is one of the major factors. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 26;218:46-54. Epub 2018 Dec 26.

Instituto de Oceanografia (IO), Universidade Federal do Rio Grande - FURG, Rio Grande, Brazil; Laboratório de Nutrição de Organismos Aquáticos (LANOA), IO, Brazil; Programa de Pós-graduação em Aquicultura, FURG, Rio Grande, Brazil. Electronic address:

This research evaluated the effect of the simultaneous substitution of fish meal and fish oil at 0, 30, 50, 70 and 100% (termed SS0, SS30, SS50, SS70 and SS100, respectively) with both Spirulina (Arthrospira platensis) and linseed oil. The effect on growth, colour, fatty acid (FA) profile, and liver and muscle antioxidant response in mullets (Mugil liza) were evaluated. A full substitution was not possible due to a final body weight reduction (p < 0. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 20;218:55-61. Epub 2018 Dec 20.

Laboratory of Biochemistry Hatisaburo Masuda, Federal University of Rio de Janeiro, NUPEM - UFRJ/Macaé, Av. São José do Barreto 764, São José do Barreto, Macaé, RJ CEP 27971-550, Brazil; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Brazil; National Institute of Science and Technology -Molecular Entomology, Rio de Janeiro, Brazil. Electronic address:

The cattle tick R. microplus is the biggest obstacle to livestock rearing in tropical countries. It is responsible for billions of dollars in losses every year, affecting meat and milk production, beef and dairy cattle, and the leather industry. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 11;218:8-13. Epub 2018 Dec 11.

Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

The aim of this study was to evaluate whether rupture on blood-brain barrier (BBB) can be a pathway for trichlorfon-induced neurotoxic effects, and to investigate its implications on oxidative status, cell viability and brain neurotransmitters in silver catfish (Rhamdia quelen). The BBB permeability was increased in fish exposed for 24 h to 22 mg/L of trichlorfon compared to the control group, as well as in those exposed to 11 and 22 mg/L of trichlorfon for 48 h. Compared to the control group, brain reactive oxygen species and lipid peroxide levels were higher when exposed to 22 mg/L of trichlorfon and 11 and 22 mg/L of trichlorfon after 24 h and 48 h, respectively, while the antioxidant capacity against peroxyl radical levels was lower. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 10;218:14-20. Epub 2018 Dec 10.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, South Australia, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Adelaide 5000, South Australia, Australia.

In an effort to overcome the palatability issues currently constraining the effective delivery of praziquantel (PZQ) via feed to treat monogenean parasites in yellowtail kingfish, this study compared the bioavailability and palatability of PZQ in hydrogenated castor oil (HCO) solid lipid nanoparticles (SLN) against pure PZQ in this species. Improving bioavailability would facilitate lower dietary inclusion levels to achieve the same therapeutic dose and therefore reduce the bitterness of feeds containing PZQ. Bioavailability was determined by co-administering feed with either pure PZQ, HCO-SLN or HCO-SLN coated with chitosan via intubation and quantifying the pharmacokinetics response. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 11;218:30-35. Epub 2018 Dec 11.

Instituto de Ciências Biológicas (ICB), Universidade Federal de Rio Grande-FURG, Rio Grande, Rio Grande do Sul-FURG, Brazil; Programa de Pós-Graduação em Ciências Fisiológicas -FAC, ICB, Universidade Federal do Rio Grande-FURG, Rio Grande, RS, Brazil; Rede de Nanotoxicologia (MCTI/CNPq), Brazil; Instituto Nacional de Ciência e Tecnologia em Nanomateriais de Carbono (CNPq), Belo Horizonte, MG, Brazil. Electronic address:

Given the increasing use of carbon nanotubes (CNT) in several industries and technological applications, it is essential to perform in vivo toxicological studies with these nanomaterials to evaluate their potential ecotoxicity. Dopamine (DA) and serotonin (5HT) are key neurotransmitters for brain functions and behavioral responses. Determination of DA and 5HT were performed in brain samples from zebrafish Danio rerio exposed i. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 4;218:1-7. Epub 2018 Dec 4.

Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Unidad Académica Mazatlán, Joel Montes Camarena s/n, Mazatlán 82040, Sinaloa, Mexico; El Colegio de Sinaloa, Centro, Culiacán, Sinaloa, Mexico. Electronic address:

This study investigated acute arsenic toxicity and bioconcentration capacity in Litopenaeus vannamei because it has been frequently exposed to lower salinities than its isosmotic point (25 g L). Juveniles (9.9 ± 0. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 4;218:21-29. Epub 2018 Dec 4.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, China. Electronic address:

A 30-days feeding trail was conducted to determine the sensitivity of Carassius auratus to the toxicological effects of elevated dietary Selenomethionine (Se-Met). C. auratus averaging 23. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 4;217:98-105. Epub 2018 Dec 4.

School of Agriculture, Ludong University, Yantai 264025, China. Electronic address:

Antioxidant enzymes play essential roles against oxidative stress caused by 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), which is ubiquitous in marine environment and organisms. However, research on antioxidant responses to BDE-47 in marine bivalves is scarce. In this study, we identified the full-length cDNA of catalase (CAT), and glutathione peroxidase (GPx) in the clam Mactra veneriformis. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 4;217:114-121. Epub 2018 Dec 4.

Laboratorio de Ecotoxicología Acuática: Invertebrados Nativos (EAIN), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428 Buenos Aires, Argentina; Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. Electronic address:

This work aimed to study in the freshwater gastropod Planorbarius corneus the effects of acute (2 days) and subchronic (14 days) exposures to an environmental concentration of the organophosphate azinphos-methyl on different reproductive parameters, offspring survival and B-esterase activities in gonads and in the whole organism soft tissue. The acute exposure inhibited only carboxylesterase activity in both tissues while the subchronic exposure also inhibited cholinesterase activity, decreased the number of hatched-eggs and increased offspring lethality (92%). On the other hand, B-esterases in gonads were more effective biomarkers than B-esterases in the whole organism due their inhibition appeared earlier in time (cholinesterase activity) and their activity remained inhibited for a longer time (carboxylesterase activity) when recovery studies were performed. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 4;217:106-113. Epub 2018 Dec 4.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Tetrabromoethylcyclohexane (TBECH), as one emerging brominated flame retardants, is ubiquitous in the environment, including water and aquatic organisms. TBECH was found to exhibit endocrine-disrupting effects in different models, whereas a survey of comprehensive toxic effects of TBECH on zebrafish is limited. In the present study, zebrafish (Danio rerio) were waterborne exposed continuously to TBECH from embryonic stage (3 h post-fertilization (hpf)) to the time when the respective parameters were evaluated. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 30;217:41-53. Epub 2018 Nov 30.

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine. Electronic address:

In recent years, Drosophila melanogaster has emerged as a model for studies on aluminum toxicity. The current study aimed to disclose the mechanisms of aluminum toxicity in D. melanogaster at larval and adult stages and examined the potential protective effects of dietary alpha-ketoglutarate (AKG). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 2;217:54-67. Epub 2018 Dec 2.

Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

Venoms of medically important scorpions from Buthidae family have been intensively studied, in contrast to non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central America. D. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 27;217:87-97. Epub 2018 Nov 27.

Department of Physiological Sciences, Center for Environmental and Human Toxicology, UF Genetics Institute, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address:

Triazole fungicides are increasingly used in North America to combat mold and fungi, in order to protect vegetables, citrus, ornamental plants and field crops. To determine the biological impacts of tebuconazole in non-target aquatic organisms, early life stage zebrafish were exposed to 0.1-100 μM tebuconazole for 120 h (5 dpf). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 27;217:68-75. Epub 2018 Nov 27.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, China; Center for Southern Economic Crops, Chinese Academy of Agricultural Sciences, China. Electronic address:

Vascular endothelial cell damage is related to many vascular diseases, including cardiovascular disease (CVD). Reactive oxygen species (ROS) play a vital role in the pathogenesis of many cardiovascular diseases. Herein, HO-induced human umbilical vein endothelial cell (HUVEC) injury model was used to explore the mechanisms involved in the pathogenesis of ROS-induced oxidative stress and cell dysfunction. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 27;217:32-40. Epub 2018 Nov 27.

Centro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP), CONICET-UNPSJB, Roca 780, 9200 Esquel, Argentina.

Environmental impairment resulted from urbanizations can produce damage on freshwater species including strong physiological effects at individual or population level. The multixenobiotic resistance (MXR) is a defence mechanism which has been demonstrated in several aquatic organisms. The key mediators of MXR activity are ATP-binding cassette (ABC) proteins like P-glycoprotein (P-gp). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 26;217:1-4. Epub 2018 Nov 26.

Department of Physical and Environmental Sciences, Texas A&M University, Corpus Christi, TX, USA.

Aquaculture presents essential opportunities to meet global food security needs, but adverse effects of aquaculture practices on ecological integrity and influences of existing waste management infrastructure on product safety must be understood in rapidly expanding urban and peri-urban regions. Concentration of, access to and use of chemical products is increasing in many urban areas faster than interventions are being implemented. Aquaculture farming is employing "non-traditional" (e. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 23;216:101-109. Epub 2018 Nov 23.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Oxidative damage is a potential physiological cost of thermoregulation during seasonal adjustments to air temperature (T) in small mammals. Here, we hypothesized that T affects serum thyroid hormone levels and these hormones can mediate the changes in metabolic rate and oxidative damage. Mongolian gerbils (Meriones unguiculatus) were acclimated at different Ts (5 °C, 23 °C and 37 °C) for 3 weeks. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 24;217:5-14. Epub 2018 Nov 24.

Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University, N18, W9, Kita-ku, Sapporo 060-0818, Japan. Electronic address:

Birds are exposed to many xenobiotics during their lifetime. For accurate prediction of xenobiotic-induced toxic effects on avian species, it is necessary to understand metabolic capacities in a comprehensive range of bird species. However, there is a lack of information about avian xenobiotic metabolizing enzymes (XMEs), particularly in wild birds. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 23;217:76-86. Epub 2018 Nov 23.

Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, United States. Electronic address:

The activities of two effectors, brevetoxin (PbTx) and manumycin-A (Man-A), of thioredoxin reductase (TrxR) have been evaluated against a series of fourteen TrxR orthologs originating from mammals, insects and protists and several mutants. Man-A, a molecule with numerous electrophilic sites, forms a covalent adduct with most selenocystine (Sec)-containing TrxR enzymes. The evidence also demonstrates that Man-A can form covalent adducts with some non-Sec-containing enzymes. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 23;217:25-31. Epub 2018 Nov 23.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, P.R. China.

Objective: Collagen antibodies in serum are involved in the pathogenesis of Rheumatoid Arthritis (RA). The objective of this study was to identify the subtype of collagen antibodies and T cell subtype distribution in pristane-induced arthritis (PIA) and to clarify their roles in the initiation and maintenance of arthritis.

Methods: Arthritis was induced in Dark Agouti (DA) rats by injection of pristane. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 16;216:93-100. Epub 2018 Nov 16.

Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brazil; Centro de Biologia Marinha, Universidade de São Paulo, São Sebastião 11600-000, SP, Brazil.

The mudflat fiddler crab Minuca rapax, typical of mangroves and intertidal zones in the Western Atlantic Ocean, responds to fluctuations in environmental parameters by biochemical and physiological adjustments. Such biochemical effects are commonly employed in environmental studies as biomarkers of estuarine contamination. This study evaluates biochemical responses in the gills and hepatopancreas of M. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 15;217:15-24. Epub 2018 Nov 15.

Department of Biology, Center for Muscle Biology, University of Kentucky, Lexington, KY 40506-0225, USA. Electronic address:

The bacterial endotoxins, lipopolysaccharides (LPS), are known to have direct effects on mammalian heart cells; thus, LPS is likely to have some effects in other cardiac models. Drosophila melanogaster was used since it serves as a model for cardiac physiology. Larvae of blow flies (Phaenicia sericata) commonly used as therapy for debriding dead tissue, are exposed to high levels of bacterial endotoxins, but their mechanisms of LPS resistance are not entirely understood. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 15;216:110-119. Epub 2018 Nov 15.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; Instituto Nacional de Medicina Tropical (INMeT), Neuquén y Jujuy s/n, 3370 Puerto Iguazú, Argentina. Electronic address:

Megalopygids Megalopyge lanata and Podalia orsilochus are common causative agents of accidents in agricultural workers. These accidents are provoked by dermal contact at their larval stage and are characterized by cutaneous reactions, such as burning pain, edema and erythema, typically mild and self-limited. There is very little information about their venoms and their toxicological implications on human health. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 10;216:19-28. Epub 2018 Nov 10.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address:

Chlorpyrifos (CPF) is widely used in agriculture and is considered one of the most toxic pesticides to fish. In this study, adult male zebrafish were exposed to CPF at concentrations of 30, 100 and 300 μg/L for 21 days. It was observed that CPF not only induced oxidative stress but also caused gut microbiota dysbiosis in the gut. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 9;216:43-51. Epub 2018 Nov 9.

Aquaculture Research Institute, Department of Fish and Wildlife Sciences, University of Idaho, Hagerman, ID 83332, USA.

Cadmium is a persistent contaminant of surface waters. The effects of cadmium on early life stages of fish are not well understood, although they are often disproportionately affected by contaminants. The objectives of this study were to examine effects of chronic exposure to environmentally relevant concentrations on growth, development, cellular stress, and glucose metabolism of channel catfish, Ictalurus punctatus. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 9;216:82-92. Epub 2018 Nov 9.

Department of Molecular Biology and Genetic, Faculty of Science, University of Erzurum Technical, TR-25240 Erzurum, Turkey.

The aim of this study was to evaluate the effectiveness of borax (BX) against heavy metal exposure on the transcriptional and biochemical reaction in vivo and alleviating effect on gill and liver tissues of rainbow trout. Due to this aim, fish were fed with different level of BX and/or copper (Cu) (1.25, 2. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 9;216:10-18. Epub 2018 Nov 9.

Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, South Korea; Research Institute of Basic Sciences, Incheon National University, Incheon 22012, South Korea; Institute of Green Environmental Research Center, 169 Gaetbeol-ro, Incheon 21999, South Korea. Electronic address:

Low concentrations of nonylphenol (NP) in aquatic environment can induce drastic effects on the endocrine system in animals. In this study, we examined the modulatory effects of NP on reproductive and physiological parameters in juveniles of the red seabream and black rockfish following waterborne NP exposure (0, 1, 10, and 50 μg L) for 60 days. In red seabream exposed to 50 μg L NP, plasma levels of 17β-estradiol (E2) and 11-ketotestosterone (11-KT) were significantly lower at 30 and 60 days, while E2 levels were slightly higher in 10 μg L-exposed individuals at day 30. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 9;216:38-42. Epub 2018 Nov 9.

Institute of Pathophysiology, Medical Faculty, University of Belgrade, Serbia.

The kidneys are recognized as a major target of cadmium-induced toxicity. However, all mechanisms that are involved in the early stages of cadmium nephrotoxicity, particularly considering low micromolar concentrations of cadmium ions (Cd) are still unknown. Therefore, the aim of this study was to investigate the effects of peritubular acute exposure to micromolar Cd concentration (2. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 9;216:29-37. Epub 2018 Nov 9.

College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia. Electronic address:

This study explored the impact of fishmeal replacement by commercial soybean meal (SM) and EnzoMeal (EZM) on Asian seabass Lates calcarifer growth performance using six diets. The six diets comprised two sources of plant proteins with three levels each, including 300 g kg soybean meal (SM30), 300 g kg EnzoMeal (EZM30), 400 g kg soybean meal (SM40), 400 g kg EnzoMeal (EZM40), 500 g kg soybean meal (SM50), and 500 g kg EnzoMeal (EZM50). The soybean level was shown to significantly affect the final fish weight, weight gain, specific growth rate (SGR), survival, feed intake, feed conversion ratio (FCR), and apparent digestibility coefficient (ADC). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 7;216:75-81. Epub 2018 Nov 7.

Institute of Modern Aquaculture Science and Engineering, Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, School of Life Science, South China Normal University, Guangzhou 510631, PR China. Electronic address:

An 8-week feeding trial was conducted to evaluate the growth performance, feed utilization and physiological status of obscure puffer, Takifugu obscurus (13.03 ± 0.14 g) fed diets in which fish meal (FM) was replaced with various levels of dehulled and defatted soybean meal (SBM): 0% (SBM0), 15% (SBM15), 30% (SBM30), 45% (SBM45), 60% (SBM60) and 75% (SBM75). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 7;216:60-66. Epub 2018 Nov 7.

Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montreal, Québec H2Y 2E7, Canada. Electronic address:

Biological organisms evolved to take advantage of recurring environmental factors which enabled them to assimilate and process metabolic energy for survival. Mitochondria display non-linear oscillations in NADH levels (i.e. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 7;216:52-59. Epub 2018 Nov 7.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address:

Camptothecin (CPT) and its derivatives show potential insecticidal activities against various insect species due to target at DNA-Topoisomerase I complex and induce apoptosis death of insect cells. Oxidative stress resulted from excessive production of reactive oxygen species (ROS) has been proved to be an important component of the mechanism of pesticide toxicity. The aim of the present study was to investigate whether CPTs promote the increasing of intracellular oxidative stress by enhancing accumulation of intracellular ROS in IOZCAS-Spex-II cells derived from Spodoptera exigua Hübner. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 8;216:67-74. Epub 2018 Nov 8.

Division of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran. Electronic address:

The present study aimed to identify differentially expressed genes (DEGs) under silver nanoparticle (AgNPs) treatment. We used a meta-analysis approach to integrate four publicly available microarray datasets, containing control and epithelium samples treated by either AgNPs- or Ag ions. The Fisher's method combined p-values of studies. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Feb 24;216:1-9. Epub 2018 Oct 24.

Department of Environmental Science, University of California, Riverside, CA, 2258 Geology, 900 University Ave., Riverside, CA 92521, USA. Electronic address:

Many reef fishes are capable of feeding on chemically-defended benthic prey, such as soft (alcyonarian) corals; however, little is known about the molecular mechanisms that underpin allelochemical biotransformation and detoxification. Butterflyfishes (Chaetodon: Chaetdontidae) are a useful group for comparatively exploring links between biotransformation enzymes and diet, because they commonly feed on chemically defended prey. Moreover, diets of some species vary among geographic locations. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 20;215:67-75. Epub 2018 Oct 20.

Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil.

Alternagin-C (ALT-C) is a disintegrin-like peptide purified from Rhinocerophis alternatus snake venom with the property of inducing vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, and angiogenesis. Therefore, this protein could be interesting as a new approach for ischemic heart diseases, an imbalance between myocardial oxygen supply and demand, leading to cardiac dysfunction. We investigated the effects of a single dose of alternagin-C (0. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 15;215:56-66. Epub 2018 Oct 15.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; International Joint Research Laboratory for Fish Immunopharmacology, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China. Electronic address:

Resveratrol, a dietary polyphenol, has been shown to exert antioxidation, hepatoprotection, anti-inflammation and immunostimulation. However, the effects and underlying mechanism of resveratrol on liver injury in fish are still unclear. In the present study, we investigated the potential protective effects and mechanism of resveratrol on oxidative stress-induced liver damage in tilapia. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 15;215:41-46. Epub 2018 Oct 15.

Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, South Africa; Biomedical Research Centre, Faculty of Veterinary Science, University of Pretoria, South Africa.

Asian Gyps vulture species are gradually recovering from the devastating effect of diclofenac being present in contaminated carcasses. This drug was responsible for the death of over 10 million vultures in India, Nepal and Pakistan. To prevent the extinction of vultures, meloxicam was introduced after the ban of veterinary diclofenac. Read More