2,033,267 results match your criteria Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology [Journal]


Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids.

Chemosphere 2018 Dec 6;219:526-537. Epub 2018 Dec 6.

Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA.

Pyrethroids are potent neurotoxicants that may elicit multiple pathways of toxicity in non-target organisms. Comparative studies on the mechanistic and developmental effects of types I and II pyrethroids against non-target aquatic species are limited. This study assessed the effects of the two pyrethroid types against embryo-larval zebrafish (Danio rerio) at environmentally relevant and laboratory concentrations. Read More

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December 2018

Detection of norovirus epidemic genotypes in raw sewage using next generation sequencing.

Environ Int 2018 Dec 12;123:282-291. Epub 2018 Dec 12.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.

Noroviruses are a leading cause of epidemic and pandemic acute gastroenteritis (AGE) worldwide, and contaminated food and water are important routes for its transmission. Raw sewage has been used for viral surveillance to monitor the emergence of new norovirus strains with the potential to cause epidemics. In this study, we investigated norovirus occurrence and norovirus RNA levels in 156 samples collected from May 2013 to May 2014, across three different stages (52 samples each) of a wastewater treatment plant (WWTP) in Rio de Janeiro, Brazil. Read More

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December 2018

Efficacy and safety of partial splenic embolization for hypersplenism in pre- and post-liver transplant patients: A 16-year comparative analysis.

Clin Imaging 2018 Nov 27;54:71-77. Epub 2018 Nov 27.

Department of Radiology, Division of Vascular and Interventional Radiology, Columbia University Medical Center, 177 Fort Washington Ave, Milstein Hospital - 4 Hudson North, New York, NY 10032, United States of America.

Purpose: To report the effect of partial splenic embolization (PSE) on hematological indices and the procedure's safety in pre- and post-liver transplant (LT) patients.

Materials And Methods: A single-center retrospective study evaluating all patients who underwent PSE over a 16-year period was performed. Inclusion criteria were splenomegaly confirmed by imaging and at least one of the following cytopenias: hemoglobin ≤10 g/dL, WBC count ≤1500 μL, or platelet count ≤100,000 μL. Read More

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November 2018

A potential regulatory network among WDR86-AS1, miR-10b-3p, and LITAF is possibly involved in preeclampsia pathogenesis.

Cell Signal 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, PR China.

Preeclampsia (PE), a pregnancy-specific disorder, is a leading cause of perinatal maternal and fetal mortality and morbidity. Impaired migration and invasion of trophoblastic cells and an imbalanced systemic maternal inflammatory response have been proposed as possible causes of pathogenesis of PE. Comparative analysis of PE-affected placentas and healthy placentas has uncovered differentially expressed long noncoding RNAs, microRNAs, and mRNAs. Read More

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December 2018

In vitro anti-inflammatory and antioxidant potential of thymol loaded bipolymeric (tragacanth gum/chitosan) nanocarrier.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

Department of Bio & Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India. Electronic address:

Thymol is a natural bioactive agent which possesses various medicinal properties like antimicrobial, antifungal, anti-inflammatory, anticancer etc. and has been widely used in traditional medicine and food industries. It is eco-friendly, cheaper, nontoxic and has been granted generally recognized as safe (GRAS) notation by USFDA. Read More

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December 2018

Binocular Visual Function with Staged Implantation of Diffractive Multifocal Intraocular Lenses with Three Add Powers.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Tokyo Dental Collage Suidobashi Hospital.

Purpose: To evaluate the binocular visual function and depth of focus after staged implantation of diffractive multifocal intraocular lenses (MIOLs) with three different add powers following cataract removal.

Design: Prospective comparative case series.

Methods: Setting: Institutional. Read More

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December 2018

Comparative risk of venous thromboembolism with tofacitinib versus tumor necrosis factor inhibitors: A cohort study of rheumatoid arthritis patients.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the risk of venous thromboembolism (VTE) with tofacitinib versus tumor necrosis factor (TNF)-inhibitors in rheumatoid arthritis (RA) patients.

Methods: RA patients initiating tofacitinib or a TNF inhibitor without use of any biologic or tofacitinib any time prior were identified from Truven MarketScan (2012-2016) or Medicare claims (parts A, B, and D, 2012-2015) and followed until treatment discontinuation, treatment switch, insurance disenrollment, or administrative censoring. The outcome of VTE was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. Read More

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December 2018

Breast lesion detection and characterization with contrast-enhanced magnetic resonance imaging: Prospective randomized intraindividual comparison of gadoterate meglumine (0.15 mmol/kg) and gadobenate dimeglumine (0.075 mmol/kg) at 3T.

J Magn Reson Imaging 2018 Dec 15. Epub 2018 Dec 15.

Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria.

Background: Contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast is highly sensitive for breast cancer detection. Multichannel coils and 3T scanners can increase signal, spatial, and temporal resolution. In addition, the T -reduction effect of a gadolinium-based contrast agent (GBCA) is higher at 3T. Read More

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December 2018

A comparative effectiveness study of degludec and insulin glargine 300U/mL in insulin-naïve patients with type 2 diabetes.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Clinical Research, Endocrine and Metabolic Consultants, Rockville, MD, USA.

Aims: To compare the real-world effectiveness of insulin degludec (degludec) and glargine 300 units/mL (glargine U300) in insulin-naïve adult patients with type 2 diabetes in routine US clinical practice.

Materials And Methods: CONFIRM is a non-interventional comparative effectiveness study following US patients across the continuum of care, through electronic medical records from multiple health systems and integrated delivery networks. Propensity-score matching controlled for confounding. Read More

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December 2018

Comparative effectiveness and harms of long-acting insulins for Type 1 and Type 2 diabetes: a systematic review and meta-analysis.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Pacific Northwest Evidence-based Practice Center Oregon Health & Science University, Portland, Oregon.

Aims: To review evidence comparing benefits and harms of long-acting insulins in Type 1 and 2 diabetes.

Methods: MEDLINE and two Cochrane databases were searched through February 2018. Two authors selected studies meeting inclusion criteria and assessed their quality. Read More

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December 2018

Environmental performance of ordinary and new generation concrete structures-a comparative analysis.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

AGH University of Science and Technology, Krakow, Poland.

The development of concrete technology results in a new generation of cement-based concrete such as high-performance concrete, self-compacting concrete and high-performance, self-compacting concrete. These concretes are characterised by better parameters not only in terms of strength and durability but also rheology of the mixtures. Obtaining such properties requires the adoption of a different composition and proportion of ingredients than ordinary concrete. Read More

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December 2018

Lessons from PrEP: A Qualitative Study Investigating How Clinical and Policy Experts Weigh Ethics and Evidence When Evaluating Preventive Medications for Use in Pregnant and Breastfeeding Women.

AIDS Behav 2018 Dec 14. Epub 2018 Dec 14.

The Ethox Centre and Wellcome Centre for Ethics & Humanities, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK.

This study explored how multinational HIV experts weigh clinical, evidential, and ethical considerations regarding pre-exposure prophylaxis in pregnant/breastfeeding women. Semi-structured interviews were conducted with experts in HIV policy, research, treatment, and implementation from three global regions. A constant comparative approach identified major themes. Read More

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December 2018

1-year outcomes of the Xen45 glaucoma implant.

Eye (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Ophthalmology Department, Yeovil Hospital, Yeovil, UK.

Objectives: To describe the 12-month outcomes of the Xen45 glaucoma stent.

Methods: Non-comparative retrospective study of all cases who underwent Xen glaucoma surgery in April 2017 or earlier and completed 12 months of follow-up. The primary outcome measures were intraocular pressure (IOP) reduction and number of glaucoma medications at 12 months postoperatively. Read More

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December 2018

Comparative metabolomics of scab-resistant and susceptible apple cell cultures in response to scab fungus elicitor treatment.

Sci Rep 2018 Dec 14;8(1):17844. Epub 2018 Dec 14.

Plant Molecular Biology Group, Biotechnology Department, Indian Institute of Technology Roorkee, Roorkee, 247667, India.

Apple scab disease caused by the fungus Venturia inaequalis is a devastating disease that seriously affects quality and yield of apples. In order to understand the mechanisms involved in scab resistance, we performed gas chromatography-mass spectrometry based metabolomics analysis of the cell culture of scab resistant cultivar 'Florina' and scab susceptible cultivar 'Vista Bella' both prior -to and -following treatment with V. inaequalis elicitor (VIE). Read More

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December 2018

Novel Polyheteroarylene Membranes for Separation of Methanol‒Hexane Mixture by Pervaporation.

Sci Rep 2018 Dec 14;8(1):17849. Epub 2018 Dec 14.

Department of Chemical Thermodynamics and Kinetics, Saint Petersburg State University, Saint Petersburg, 198504, Russia.

Polymer membranes with improved transport properties are required for effective separation of organic mixtures (such as methanol‒hexane system) by combination of pervaporation and azeotropic distillation. The present work is devoted to comparative study of two types of membranes based on poly(amidoimide acid) with 2,2'-biquinoline-6,6' units in the backbone; the objects were prepared (i) from the initial polymer and (ii) from the polymer-metal complex (with Cu(I)). Thermo-mechanical and mass spectrometric investigations demonstrated good operational properties of the samples. Read More

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December 2018

survival duration in manure-amended soils is affected by spatiotemporal, agricultural, and weather factors: a multi-season, multi-site field study in the Mid-Atlantic U.S.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

University of Maryland Eastern Shore Department of Agriculture, Princess Anne, MD.

Untreated biological soil amendments of animal origin (BSAAO), like manure, are commonly used to fertilize soils for growing fruit and vegetable crops, and can contain enteric bacterial foodborne pathogens. Little is known about the comparative longitudinal survival of pathogens in agricultural fields containing different types of BSAAO, and field data may be useful to determine intervals between manure application and harvest of produce intended for human consumption to minimize foodborne illness. This study generated 324 survival profiles from 12 different field trials at three different sites (UMES, PA, BARC) in the Mid-Atlantic U. Read More

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December 2018

Population genetics and characterization of isolates in western jackdaws and game birds in Finland.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, FI-00014, Finland

Poultry is considered a major reservoir and source of human campylobacteriosis but the roles of environmental reservoirs, including wild birds, have not been assessed in depth. In this study, we isolated and characterized from western jackdaws (n=91, 43%), mallard ducks (n=82, 76%) and pheasants (n=9, 9%). Most of the western jackdaw and mallard duck isolates represented MLST sequence types (STs) that diverged from those previously isolated from human patients and various animal species, whereas all pheasant isolates represented ST-19, a common ST among human patients and other hosts worldwide. Read More

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December 2018

A quantitative framework for characterizing the evolutionary history of mammalian gene expression.

Genome Res 2018 Dec 14. Epub 2018 Dec 14.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 752 36 Uppsala, Sweden.

The evolutionary history of a gene helps predict its function and relationship to phenotypic traits. Although sequence conservation is commonly used to decipher gene function and assess medical relevance, methods for functional inference from comparative expression data are lacking. Here, we use RNA-seq across seven tissues from 17 mammalian species to show that expression evolution across mammals is accurately modeled by the Ornstein-Uhlenbeck process, a commonly proposed model of continuous trait evolution. Read More

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December 2018

Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.

Bioorg Med Chem 2018 Nov 14. Epub 2018 Nov 14.

Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, United States; Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesized using ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-l-glutamic acid, as a molecular template in order to better understand the impact of replacing one of the two nitrogen atoms in the urea-based GCPII inhibitor with an oxygen atom. Compound 7 containing a C-terminal 2-oxypentanedioic acid was more potent than compound 5 containing a C-terminal glutamic acid (2-aminopentanedioic acid) despite GCPII's preference for peptides containing an N-terminal glutamate as substrates. Subsequent crystallographic analysis revealed that ZJ-43 and its two carbamate analogs 5 and 7 with the same (S,S)-stereochemical configuration adopt a nearly identical binding mode while (R,S)-carbamate analog 8 containing a d-leucine forms a less extensive hydrogen bonding network. Read More

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November 2018

Alcohol and drug screening of adolescent trauma alert patients at a level 1 pediatric trauma center.

Am J Emerg Med 2018 Dec 7. Epub 2018 Dec 7.

Trauma Program, Department of Pediatric Surgery, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, United States of America; Center for Pediatric Trauma Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, United States of America; The Ohio State University College of Medicine, 370 West 9(th) Avenue, Columbus, OH 43210, United States of America. Electronic address:

Background: Adolescent trauma patients are reported to have increased incidence of alcohol and other drug (AOD) use, but previous studies have included inadequate screening of the intended populations. A Level 1 Pediatric Trauma Center achieved a 94% rate of AOD screening. We hypothesized that a positive AOD screening result is associated with males, increasing age, lower socioeconomic status, violent injury mechanism, higher Injury Severity Score (ISS), lower GCS, need for operation and increased hospital length of stay. Read More

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December 2018

G protein-coupled receptors in arthropod vectors: omics and pharmacological approaches to elucidate ligand-receptor interactions and novel organismal functions.

Curr Opin Insect Sci 2018 Oct 26;29:12-20. Epub 2018 May 26.

Department of Electrical and Computer Engineering, TAMU, College Station, TX 77843-3128, United States.

Regulation of many physiological processes in animals, certainly those controlled by neuropeptide hormones, involves G protein-coupled receptors (GPCRs). Our work focusing on endocrine regulation of diuresis and water balance in mosquitoes and ticks started in 1997 with the kinin receptor, at the dawn of the omics era. After the genomic revolution, we began work on the endocrinology of reproduction in the red imported fire ant. Read More

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October 2018

The immediate sensorimotor effects of elbow orthoses in patients with lateral elbow tendinopathy: a prospective crossover study.

J Shoulder Elbow Surg 2019 Jan;28(1):e10-e17

Musculoskeletal Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Counterforce orthoses are used to manage lateral elbow tendinopathy, and their effectiveness in improving motor function has been documented. Little is known about the impact of bracing on sensory function. The objective of this study was to investigate the immediate effectiveness of 2 counterforce orthoses in improving the sensorimotor abilities of the hand in patients with lateral elbow tendinopathy. Read More

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January 2019

Cost-effectiveness analysis of total elbow arthroplasty versus open reduction-internal fixation for distal humeral fractures.

J Shoulder Elbow Surg 2019 Jan;28(1):102-111

Division of Sports Medicine, Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

Background: Total elbow arthroplasty (TEA) and open reduction-internal fixation (ORIF) are 2 viable surgical treatment options for acute, intra-articular distal humeral fractures in elderly patients. Whereas recent systematic reviews and randomized trials have suggested that TEA and ORIF result in similar functional outcome scores, no previous study has assessed the comparative cost-effectiveness between TEA and distal humeral ORIF in this specific demographic.

Methods: A Markov model was created with the highest-level data available from the literature depicting transitioning health states based on treatment strategies. Read More

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January 2019

Comparative study of cultures and next-generation sequencing in the diagnosis of shoulder prosthetic joint infections.

J Shoulder Elbow Surg 2019 Jan;28(1):1-8

Department of Orthopaedic Surgery, Rothman Institute-Thomas Jefferson University, Philadelphia, PA, USA.

Background: Serum and synovial markers used to diagnose lower extremity prosthetic joint infection (PJI) have performed poorly for shoulder PJI. As a result, diagnosis is commonly reliant on the accuracy of positive or negative cultures. Next-generation sequencing (NGS) can sequence an entire bacterial genome. Read More

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January 2019

Sociality and communicative complexity: insights from the other insect societies.

Curr Opin Insect Sci 2018 Aug 10;28:19-25. Epub 2018 Apr 10.

Institute of Insect Biotechnology, University of Gießen, 35392 Gießen, Germany. Electronic address:

Recognition and communication are essential processes when it comes to interaction of organisms with their biotic environment. As especially social interactions are coordinated by communication, it has been predicted that social evolution drives communicative complexity. However, studies comparing olfactory signals or receptor repertoires of solitary and eusocial insects found only mixed evidence for the social complexity hypothesis. Read More

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Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons.

Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.

Institute of Mobilome and Genome, College of Animal Science & Technology, Yangzhou University, Yangzhou 225009, China.

Although transposon-mediated enhancer trapping (ET) is successfully applied in diverse models, the efficiency of various transposon systems varies significantly, and little information is available regarding efficiency of enhancer trapping by various transposons in zebrafish. Most potential enhancers (Ens) still lack evidence of actual En activity. Here, we compared the differences in ET efficiency between (), () and transposons. Read More

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December 2018

Impact of the Family Environment on Juvenile Mental Health: eSports Online Game Addiction and Delinquency.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Department of Sports Taekwondo, Graduate School of Physical Education, Kyung Hee University, Seocheon-dong 1, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Korea.

Family types in Asian countries are rapidly changing as the society is changing. Thus, in this study, we analyzed and compared how the newly evolving family types (multicultural/dual-income) affect adolescents' online game addiction, delinquency, and online gaming (eSports) participation motivation. Multiple regression analysis was performed to examine the causal relationships between the variables, and multivariate analysis of variance and analysis of variance were performed for comparative analyses. Read More

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December 2018

Defense Mechanisms of Two Pioneer Submerged Plants during Their Optimal Performance Period in the Bioaccumulation of Lead: A Comparative Study.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Institute of Ecology and Environment, State Key Laboratory of Hydraulics and Mountain River Engineering, College of Water Resource & Hydropower, Sichuan University, Chengdu 610065, China.

L. and (L.f. Read More

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December 2018

Comparative Evaluation of Phytochemicals, and Antidiabetic and Antioxidant Activities of Cuscuta reflexa Grown on Different Hosts in Northern Thailand.

Nat Prod Commun 2017 Jan;12(1):51-54

For the first time, total phytochemical profiles of methanol crude extracts of Cuscuta reflexa grown on three different hosts, Coccinia grandis, Ficus racemosa- and Samanea saman, that were cultivated in northern Thailand were examined, along with their antidiabetic and antioxidant activities. The highest level of total flavonoids (114.4 mg QE/ g extract) and total phenolic content (90. Read More

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January 2017

Cytotoxic Effects of Resveratrol, Rutin and Rosmarinic Acid on ARH-77 Human (Multiple Myeloma) Cell Line.

Nat Prod Commun 2016 Oct;11(10):1441-1444

Multiple myeloma (MM) cancers are 10% of hematological cancers. Leukemia ARH-77 is a malignancy like MM with a worse course of disease and the survival rate from it is very low. Therefore, ARH-77 is a commonly used model for antitumor agent studies. Read More

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October 2016

Comparative Analysis of the Exposure and Surgical Freedom of the Endoscopic Extended Minipterional Craniotomy and the Transorbital Endoscopic Approach to the Anterior and Middle Cranial Fossae.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Numerous minimally invasive approaches to the skull base have been successively developed. Knowledge of the surgical nuances of a specific approach may facilitate approach selection. This study sought to compare the nuances of an extended version of the minipterional craniotomy (EMPT) with those of the transorbital endoscopic approach (TOEA) to the anterior and middle cranial fossae (ACF and MCF, respectively). Read More

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December 2018

Comparative immunogenicity of enhanced seasonal influenza vaccines in older adults: a systematic review and meta-analysis.

J Infect Dis 2018 Dec 14. Epub 2018 Dec 14.

Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Introduction: A number of enhanced influenza vaccines have been developed for use in older adults, including the high-dose, MF59-adjuvanted, and intradermal vaccines.

Methods: We conducted a systematic review examining the improvements in antibody responses measured by the hemagglutination inhibition (HAI) assay associated with these enhanced vaccines, compared to each other, and compared to standard-dose vaccine using random effects models.

Results: Thirty-nine trials were included. Read More

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December 2018

A comparative study of thermal stability of TNT, RDX, CL20 and ANTA explosives using UV 266nm-time resolved photoacoustic pyrolysis technique.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 6;211:212-220. Epub 2018 Dec 6.

Advanced Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad, 500046, India. Electronic address:

The paper reports the potential use of UV based pulsed photoacoustic spectroscopy to study the thermal stability of some well-known premier explosives such as TNT, RDX, CL20, and ANTA between 30 and 350°C range. The thermal PA spectra of samples were recorded using fourth harmonic wavelength i.e. Read More

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December 2018

When is a "cryptic" species not a cryptic species: A consideration from the Holarctic micro-landsnail genus Euconulus (Gastropoda: Stylommatophora).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Botany and Zoology, Masaryk University, Kotlářská 2, CZ-61137, Brno, Czechia. Electronic address:

Naive use of molecular data may lead to ambiguous conclusions, especially within the context of "cryptic" species. Here, we integrated molecular and morphometric data to evaluate phylogenetic relationships in the widespread terrestrial micro-snail genus, Euconulus. We analyzed mitochondrial (16S + COII) and nuclear (ITS1 + ITS2) sequence across 94 populations from Europe, Asia and North America within the nominate species E. Read More

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December 2018

Acoustic prepulse inhibition in male and female prairie voles: Implications for models of neuropsychiatric illness.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

Oregon Health & Science University, Portland, OR, United States; VA Portland Health Care System, Portland, OR. United States. Electronic address:

Sensory gating, the ability to suppress sensory information of irrelevant stimuli, is affected in several neuropsychiatric diseases, notably schizophrenia and autism. It is currently unclear how these deficits interact with other hallmark symptoms of these disorders, such as social withdrawal and difficulty with interpersonal relationships. The highly affiliative prairie vole (Microtus ochrogaster) may be an ideal model organism to study the neurobiology underlying social behavior. Read More

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December 2018

Cellular landmarks of Trypanosoma brucei and Leishmania mexicana.

Mol Biochem Parasitol 2018 Dec 11. Epub 2018 Dec 11.

The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK. Electronic address:

The kinetoplastids Trypanosoma brucei and Leishmania mexicana are eukaryotes with a highly structured cellular organisation that is reproduced with great fidelity in each generation. The pattern of signal from a fluorescently tagged protein can define the specific structure/organelle that this protein localises to, and can be extremely informative in phenotype analysis in experimental perturbations, life cycle tracking, post-genomic assays and functional analysis of organelles. Using the vast coverage of protein subcellular localisations provided by the TrypTag project, an ongoing project to determine the localisation of every protein encoded in the T. Read More

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December 2018

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit resistivity towards various classes of antibiotics that shows that there is a dire need to search more drug targets by exploiting the full genome of the bacteria. Read More

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December 2018

Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; Omics Center for Agriculture, Bioresources, Food, and Health, Faculty of Science, Kasetsart University (OmiKU), Bangkok, 10900, Thailand. Electronic address:

Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Read More

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December 2018

A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care.

J Pain Symptom Manage 2018 Dec 11. Epub 2018 Dec 11.

Division of Palliative Care, Dept of Medicine, University of Ottawa; Ottawa, ON, Canada; Bruyère Continuing Care; Ottawa, ON, Canada; Bruyère Research Institute; Ottawa, ON, Canada; Ottawa Hospital Research Institute; Ottawa, ON, Canada.

Context: Based on the clinical care pathway of delirium in palliative care (PC), a published analytic framework (AF) formulated research questions in key domains and recommended a scoping review to identify evidence gaps.

Objectives: To produce a literature map for key domains of the published AF: screening; prognosis and diagnosis; management and the health-related outcomes.

Methods: A standard scoping review framework was used by an interdisciplinary study team of nurse and physician delirium researchers, an information specialist and review methodologists to conduct the review. Read More

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December 2018

Interactions of mannose binding-lectin with red blood cells by employing cationic quantum dots.

Int J Biol Macromol 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:

Mannose-binding lectin (MBL) plays important roles by interacting with specific molecular patterns on cell surfaces, triggering first-line host defense. We investigated the MBL interaction with healthy red blood cell membranes as well as its effects on the membrane rheology. We explored electrostatic interactions between cationic quantum dots (QDs) and negatively charged red blood cell surfaces to quantitatively evaluate membrane electrical charges as well as to investigate the MBL binding to healthy erythrocytes. Read More

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December 2018

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Cell 2018 Dec;175(7):1931-1945.e18

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA. Electronic address:

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We used affinity purification-mass spectrometry (AP-MS) to compare flavivirus-host interactions for two viruses (DENV and ZIKV) in two hosts (human and mosquito). Read More

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December 2018

The Role of Common Factors in Psychotherapy Outcomes.

Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:

Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More

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December 2018
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The Drying Kinetics of Salt Solution Droplets: Water Evaporation Rates and Crystallisation.

J Phys Chem B 2018 Dec 14. Epub 2018 Dec 14.

The drying and crystallisation of solution droplets is a problem of broad relevance, determining the micro-structures of particles formed in spray drying, the phase of particles delivered by, for example, aerosol formulations for inhalation therapies, and the impact of aerosols on radiative forcing and climate. The ephemeral nature of free-droplets, particularly when considering the drying kinetics of droplets with highly volatile constituents, has often precluded the accurate measurement of transient properties such as droplet size and composition, preventing the robust assessment of predictive models of droplet drying rates, nucleation and crystallisation. Here, we report novel measurements of the drying kinetics of individual aqueous sodium chloride solution droplets using a comparative-kinetics electrodynamic balance to isolate and trap single aerosol droplets (radius ~ 25 µm). Read More

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December 2018

Unbiased Measurement of Phosphate and Phosphorus Speciation in Surface Waters.

Environ Sci Technol 2018 Dec 14. Epub 2018 Dec 14.

Trace-level phosphate analysis and phosphorus speciation in surface water remained challenging due to adsorption and phosphate uptake by microorganisms. In this study a two-dimensional ion chromatography separation coupled to electrospray ionization high-resolution mass spectrometry (2D-IC-ESI-MS) allowed isotope dilution quantitation of phosphate with simultaneous analysis of eleven phosphate-containing metabolites and two inorganic condensed phosphates. Samples were collected from Lake St. Read More

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December 2018

Comparison of classical and transgenic genetic sexing strains of Mediterranean fruit fly (Diptera: Tephritidae) for application of the sterile insect technique.

PLoS One 2018 14;13(12):e0208880. Epub 2018 Dec 14.

Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.

The development of genetic sexing strains (GSSs) based on classical genetic approaches has revolutionized the application of the sterile insect technique (SIT) against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). The global use of Mediterranean fruit fly GSS for SIT applications as part of area-wide integrated pest management (AW-IPM) programmes is testimony to their effectiveness. During recent years, transgenic sexing strains (TSSs) have been developed through genetic engineering techniques offering the possibility to produce male-only progeny by introducing female embryonic lethal genes and to increase the efficacy to identify released sterile males by means of the expression of fluorescent transgene markers. Read More

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December 2018

A Prospective Comparative Study Between Subcuticular and Sutureless Technique of Skin Closure Following External Dacryocystorhinostomy.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Orbit Oculoplasty Reconstructive and Aesthetic Services, Aditya Birla Sankara Nethralaya, Kolkata, India.

Purpose: To compare the cosmetic outcome of the surgical scar of external dacryocystorhinostomy by the subcuticular versus sutureless technique.

Methods: This was a prospective interventional randomized control study conducted at tertiary level hospital. Fifty patients of primary-acquired nasolacrimal duct obstruction were included in this study. Read More

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December 2018
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Comparison of Distraction Osteogenesis and Single-Stage Remodeling for Correction of Unilateral Coronal Craniosynostosis.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Plastic and Reconstructive Surgery, Dalhousie University, Halifax.

Background: Unilateral coronal craniosynostosis is a challenging condition in craniofacial surgery. Frontoorbital advancement by single-stage resorbable remodeling and distraction osteogenesis (DO) techniques have known intraoperative differences, but their comparative outcomes are less well characterized.

Methods: A systematic literature search of the MEDLINE, EMBASE, LILACS, and Web of Science databases was conducted. Read More

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December 2018

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics.

FASEB J 2018 Dec 14:fj201801843R. Epub 2018 Dec 14.

Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Bioenergetic failure, oxidative stress, and changes in mitochondrial morphology are common pathologic hallmarks of amyotrophic lateral sclerosis (ALS) in several cellular and animal models. Disturbed mitochondrial physiology has serious consequences for proper functioning of the cell, leading to the chronic mitochondrial stress. Mitochondria, being in the center of cellular metabolism, play a pivotal role in adaptation to stress conditions. Read More

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December 2018

[Study of cone-beam CT in evaluating the electrode array of cochlear implantation postoperatively].

Authors:
Y S Song S S Gong

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1371-1373

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

To explore ways of evaluating morphological information of cochlea electrode in post cochlear implantation patients, and so as to make sure its value of clinical usage.A series of 52 patients who were diagnosed as severe to profound sensorineural hearing loss and received cochlear implantation were admitted. All the patients had cone-beam CT scanning of the operated side 1 or 2 days after operation. Read More

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September 2018
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