673,884 results match your criteria Community Oncology[Journal]


Réduire les inégalités subies par une communauté amérindienne au Brésil : le rôle social de l?université.

Sante Publique 2018 Sep;S2(HS2):105-110

The objective of this article is to describe and analyse the actions developed by a health promotion programme between 2013 and 2014 in an indigenous Kiriri community in Bahia, Brazil. One of the specificities of the programme was that it was conducted in the context of the extension activities of Brazilian universities. This programme illustrates the actions of extension, a longstanding social function of Brazilian universities and the value of involving the university in community health actions. Read More

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September 2018
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Unsupervised GRN Ensemble.

Methods Mol Biol 2019 ;1883:283-302

Bioinformatics and Systems Biology (BioSys) Unit, Université de Liège, Liège, Belgium.

Inferring gene regulatory networks from expression data is a very challenging problem that has raised the interest of the scientific community. Different algorithms have been proposed to try to solve this issue, but it has been shown that different methods have some particular biases and strengths, and none of them is the best across all types of data and datasets. As a result, the idea of aggregating various network inferences through a consensus mechanism naturally arises. Read More

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January 2019
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The Interaction of Race and Gender as a Significant Driver of Racial Arrest Disparities for African American Men.

J Urban Health 2018 Dec 13. Epub 2018 Dec 13.

San Diego School of Medicine, Center on Gender Equity and Health, University of California, San Diego, La Jolla, CA, USA.

The mass incarceration of African Americans is both a driver of racial health inequalities in the USA. Systemic social biases which associate African American men with criminality, violence, and as a particular threat to white women may partially explain their over-representation in the criminal justice system. We combined data from the Washington, DC Metro Police Department (MPD) and the American Community Survey to test whether neighborhood-level gender, race, and economic makeup were associated with elevated drug-related arrest disproportions for African American men. Read More

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December 2018

Spatial and temporal heterogeneity in the structure and function of sediment bacterial communities of a tropical mangrove forest.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Wetland Research and Training Centre, Chilika Development Authority, Balugaon, Odisha, 752030, India.

Bacterial communities of mangrove sediments are well appreciated for their role in nutrient cycling. However, spatiotemporal variability in these communities over large geographical scale remains understudied. We investigated sediment bacterial communities and their metabolic potential in an intertidal mangrove forest of India, Bhitarkanika, using high-throughput sequencing of 16S rRNA genes and community-level physiological profiling. Read More

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December 2018

The bacteriology in adult patients with pneumonia and parapneumonic effusions: increased yield with DNA sequencing method.

Eur J Clin Microbiol Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Solna, Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

The aim of this study was to use a 16S rDNA sequencing method in combination with conventional culture in patients with parapneumonic effusions (PPE) to evaluate the methods, study the microbiological spectrum, and examine the presence of bacteria within the different stages of PPE. Adults with community-acquired pneumonia (CAP) and PPE (n = 197) admitted to the Departments of Infectious Diseases at four hospitals in Stockholm County during 2011-2014 were prospectively studied. All patients underwent thoracentesis. Read More

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December 2018

Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity.

J Comput Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Unité de Neurosciences, Information et Complexité, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.

Many neurons possess dendrites enriched with sodium channels and are capable of generating action potentials. However, the role of dendritic sodium spikes remain unclear. Here, we study computational models of neurons to investigate the functional effects of dendritic spikes. Read More

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December 2018

Public housing and healthcare use: an investigation using linked administrative data.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Department of Community Health Sciences, University of Manitoba, S113-750 Bannatyne Ave, Winnipeg, Manitoba, R3E 0W3, Canada.

Objective: This study investigated whether a move to public housing affects people's use of healthcare services.

Method: Using administrative data from Manitoba, the number of hospitalizations, general practitioner (GP), specialist and emergency department (ED) visits, and prescription drugs dispensed in the years before and after the housing move-in date (2012/2013) were measured for a public housing and matched cohort. Generalized linear models with generalized estimating equations tested for differences between the cohorts in utilization trends. Read More

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December 2018

Disability trends in Canada: 2001-2014 population estimates and correlates.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Social Science Centre, University of Western Ontario, 1151 Richmond Street, London, ON, N6G 2V4, Canada.

Objectives: Disability is a major concern for the health of midlife and older Canadians. Understanding disability trends is critical for detecting socio-economic and health precursors that could be amenable to policy interventions. The purpose of this study is to assess trends in rates of disability among Canadian adults age 40-64 and 65+. Read More

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December 2018

An Examination of Preterm Birth and Residential Social Context among Black Immigrant Women in California, 2007-2010.

J Community Health 2018 Dec 13. Epub 2018 Dec 13.

Program in Public Health, University of California, Irvine, Irvine, CA, USA.

The foreign-born black population contributes a considerable amount of heterogeneity to the US black population. In 2005, black immigrants accounted for 20% of the US black population. Compared to native-born black women, black immigrant women are at lower risk for adverse birth outcomes, including preterm birth. Read More

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December 2018

Comparative analysis of the intestinal bacterial community and expression of gut immunity genes in the Chinese Mitten Crab (Eriocheir sinensis).

AMB Express 2018 Dec 13;8(1):192. Epub 2018 Dec 13.

Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.

Remarkably little information is available about the interaction between the gut microbiota and intestinal immunity in fish and crustaceans. In our study, we used Illumina MiSeq sequencing and real-time quantitative PCR to compare the microbial community and immunity genes expression in the foregut, midgut and hindgut of Chinese mitten crab (Eriocheir sinensis). Our results indicated that the community richness of the midgut is higher than in the foregut or the hindgut, although the bacterial diversity in the hindgut is higher. Read More

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December 2018

Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Private Bag 23, Hobart, TAS, 7000, Australia.

Aims/hypothesis: The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline.

Methods: Participants without dementia aged 55-90 years from the Cognition and Diabetes in Older Tasmanians (CDOT) study underwent brain MRI (ventricular and total brain volume) and neuropsychological measures (global function and seven cognitive domains) at three time points over 4.6 years. Read More

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December 2018

Prevalence of anxiety disorders and symptoms in people with hearing impairment: a systematic review.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Psychiatry, University College London, 6th Floor Maple House, 149 Tottenham Court Road, London, W1T 7BN, UK.

Purpose: Anxiety disorders are common. Prevalence is likely to be raised in people with hearing impairment, who experience higher rates of associated risk factors. We conducted, to our knowledge, the first systematic review of the prevalence and correlates of anxiety in people with hearing impairment. Read More

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December 2018

SIU-ICUD consultation on bladder cancer: basic science.

World J Urol 2018 Dec 13. Epub 2018 Dec 13.

Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.

Purpose: To provide a condensed summary of the Basic Science chapter that was included in the Third International Consultation on Bladder Cancer.

Methods: World bladder cancer basic science experts used the published literature to create summaries of recent progress in their areas of expertise.

Results: The completion of several large-scale genomics projects coupled with a strong collaborative culture within the research community and the exciting clinical activity of immune checkpoint blockade have combined to transform the bladder cancer research landscape. Read More

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December 2018

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

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December 2018

Influence spreading model used to analyse social networks and detect sub-communities.

Authors:
Vesa Kuikka

Comput Soc Netw 2018 29;5(1):12. Epub 2018 Nov 29.

Finnish Defence Research Agency, PO BOX 10, Tykkikentäntie 1, 11311 Riihimäki, Finland.

A dynamic influence spreading model is presented for computing network centrality and betweenness measures. Network topology, and possible directed connections and unequal weights of nodes and links, are essential features of the model. The same influence spreading model is used for community detection in social networks and for analysis of network structures. Read More

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November 2018

The Life and Work of Nikolai Ivanovich Pirogov (1810-1881): An Outstanding Anatomist and Surgeon.

Cureus 2018 Oct 8;10(10):e3424. Epub 2018 Oct 8.

Otolaryngology, Aristotle University of Thessaloniki, Thessalonki, GRC.

Nikolai Ivanovich Pirogov is considered one of the most important anatomists and surgeons in the history of medicine. The Russian physician conducted more than 11,000 dissections and meticulously studied human anatomy, discovering important anatomical regions such as Pirogov's triangle. Pirogov developed surgical methods and techniques used by physicians for many decades such as Pirogov's amputation. Read More

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October 2018

Regional working in the East of England: using the UK National Standards for Public Involvement.

Res Involv Engagem 2018 6;4:48. Epub 2018 Dec 6.

1Centre for Research in Public Health and Community Care (CRIPACC), University of Hertfordshire, Hatfield, AL10 9AB UK.

Plain English Summary: Involving patients and members of the public to help shape and carry out research is recommended in health research in the United Kingdom (UK). There are a number of regional networks of Patient and Public Involvement (PPI) groups, which support the collaboration between researchers, patients and public members. We are a group of researchers, patients and public members who came together via a PPI regional network in the East of England to collaborate on a research study about the extent of feedback from researchers to PPI contributors. Read More

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December 2018

Beneficial effect of additional treatment with widely available anticancer agents in advanced small lung cell carcinoma: A case report.

Authors:
Piotr J Kruk

Mol Clin Oncol 2018 Dec 5;9(6):647-650. Epub 2018 Oct 5.

Department of Family Medicine, Rząśnia Community-Based Health Center, 98-332 Rząśnia, Poland.

Small-cell lung carcinoma is a type of lung cancer characterized by very poor prognosis, as the majority of the patients have already developed metastases at initial diagnosis. Small-cell lung cancer accounts for ~15% of all lung cancer cases. The present study reports the case of a female patient with advanced-stage small-cell lung cancer. Read More

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December 2018

Effect of enhanced detailing and mass media on community use of oral rehydration salts and zinc during a scale-up program in Gujarat and Uttar Pradesh.

J Glob Health 2019 Jun;9(1):010501

Clinton Health Access Initiative, New Delhi, India.

Background: The Clinton Health Access Initiative implemented a program from 2012-2016 to increase use of oral rehydration salts (ORS) and zinc to treat diarrhea in children under five in three states in India: Gujarat, Madhya Pradesh, and Uttar Pradesh. The program interventions included detailing and development of a rural supply chain to reach private rural health care providers, training of Accredited Social Health Activists (ASHAs), technical support to the state governments, and a mass media campaign targeted at caregivers. In Gujarat and Uttar Pradesh, some of the program activities, such as detailing and ASHA trainings, were targeted to high-burden focal districts, thus providing an opportunity to study their effect compared to statewide activities that covered all districts, such as the mass media campaign. Read More

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Community Violence and Associated Psychological Problems Among Adolescents in the General Population.

J Child Adolesc Trauma 2018 2;11(4):411-420. Epub 2018 Jun 2.

4School of Social Work, Université de Montréal, Montréal, Canada.

Based on a populational survey conducted among 1400 adolescents aged between 12 and 17 years old, the aim of this study is to assess the relationships between their community violence experiences and their psychological health (anger, depressive symptoms, and post-traumatic stress disorder symptoms). One MANOVA confirms that both boys and girls who report at least one incident of physical community violence present more psychological difficulties, especially anger. Subsequent MANOVAs show that anger intensity varies depending on whether the youth was a direct victim or a witness only, as well as on the diversity of the types of violent manifestations and on acquaintance with the perpetrator, whereas the presence of injuries has no significant effect. Read More

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The relationship between the houseboundedness and frailty of community-dwelling elderly persons.

J Rural Med 2018 Nov 29;13(2):141-150. Epub 2018 Nov 29.

Uji City, Kyoto Prefecture, Japan.

This study aimed to verify whether the incidence of frailty in elderly individuals is higher among those who are housebound than those who are not. This study found no correlation between elderly people's houseboundedeness and physical, mental, social, and overall frailty. However, the Tilburg Frailty Indicator (TFI) frailty score and grip strength value were higher in non-housebound elderly persons than in housebound elderly ones. Read More

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November 2018

Improvements in self-care among patients with diabetes in a remote island in Japan: a pilot study.

J Rural Med 2018 Nov 29;13(2):134-140. Epub 2018 Nov 29.

Minamidaito Village Office, Japan.

The traits of the inhabitants of rural areas could affect clinical improvements. In the rural areas of Japan, a feeling of competitiveness often exists between the members of a community; this competitiveness could prompt patients to exert efforts in improving their health. This study aimed to assess the effects of competitiveness on the clinical outcomes of patients with diabetes. Read More

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November 2018

Regular medications prescribed to elderly neurosurgical inpatients and the impact of hospitalization on potentially inappropriate medications.

J Rural Med 2018 Nov 29;13(2):97-104. Epub 2018 Nov 29.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Japan.

This study aimed to evaluate the regular medications prescribed to elderly neurosurgical inpatients in community hospitals in Japan. Elderly patients (aged ≥ 65 years) who had been admitted to neurosurgery departments from April 2015 to March 2017 were enrolled in this study. We collected data on regular medications at the time of admission and discharge. Read More

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November 2018

Giving Voice to Patients: Developing a Discussion Method to Involve Patients in Translational Research.

Nanoethics 2018 9;12(3):181-197. Epub 2018 Jul 9.

4Wageningen University and Research, Wageningen, The Netherlands.

Biomedical research policy in recent years has often tried to make such research more 'translational', aiming to facilitate the transfer of insights from research and development (R&D) to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. Read More

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Microbiota dysbiosis is associated with HPV-induced cervical carcinogenesis.

Oncol Lett 2018 Dec 26;16(6):7035-7047. Epub 2018 Sep 26.

Department of Molecular Virology, Adam Mickiewicz University, 61-712 Poznan, Poland.

Cervical microbial communities serve a crucial role in the persistence and development of oncogenic human papilloma virus (HPV) infections. In the present study, the authors hypothesised that disturbed heterogeneity of microbial flora was associated with HPV-induced carcinogenesis. Swabs of the cervical microbiota were collected from 250 women and the 16S ribosomal DNA was sequenced using a high throughput assay. Read More

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December 2018

Extreme Geochemical Conditions and Dispersal Limitation Retard Primary Succession of Microbial Communities in Gold Tailings.

Front Microbiol 2018 28;9:2785. Epub 2018 Nov 28.

School of Earth and Environmental Sciences, The University of Queensland, St Lucia, QLD, Australia.

Microbial community succession in tailings materials is poorly understood at present, and likely to be substantially different from similar processes in natural primary successional environments due to the unusual geochemical properties of tailings and the isolated design of tailings storage facilities. This is the first study to evaluate processes of primary succession in microbial communities colonizing unamended tailings, and compare the relative importance of stochastic (predominantly dust-borne dispersal) and deterministic (strong selection pressures from extreme geochemical properties) processes in governing community assembly rates and trajectories to those observed in natural environments. Dispersal-based recruitment required > 6 months to shift microbial community composition in unamended, field-weathered gold tailings; and in the absence of targeted inoculants, recruitment was dominated by salt- and alkali-tolerant species. Read More

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November 2018

Role of Bentonite on the Mobility of Antibiotic Resistance Genes, and Microbial Community in Oxytetracycline and Cadmium Contaminated Soil.

Front Microbiol 2018 28;9:2722. Epub 2018 Nov 28.

Key Laboratory of Plant Nutrition and Agri-Environment in Northwest China, College of Natural Resources and Environment, Northwest A&F University, Yangling, China.

The effects of bentonite (BT), a commonly used heavy metal deactivator, on the ARGs and microbial communities in soils and lettuce systems contaminated by heavy metals and antibiotics are unclear. A study was conducted to investigate the effect of BT on the mobility of antibiotic resistance genes in oxytetracycline and cadmium contaminated soil. Results showed that the addition of BT reduced the accumulation of OTC and ARGs in the soil and lettuce roots, but increased the abundance of ARGs in lettuce leaves, and increase the risk of human pathogenic bacteria (HPB) transferring to lettuce leaves. Read More

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November 2018

Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects: Between Compensation and Resilience?

Front Psychiatry 2018 28;9:541. Epub 2018 Nov 28.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Symptoms of anxiety are present not only in panic disorder or other anxiety disorders, but are highly prevalent in the general population. Despite increasing biological research on anxiety disorders, there is little research on understanding subclinical or sub-threshold symptoms relating to anxiety in non-clinical community samples, which could give clues to factors relating to resilience or compensatory changes. This study focused on brain structural correlates of subclinical anxiety/agoraphobia symptoms from a multi-center imaging study. Read More

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November 2018

The Connected Community Pharmacy: Benefits for Healthcare and Implications for Health Policy.

Front Pharmacol 2018 28;9:1352. Epub 2018 Nov 28.

SGS PharmaSolutions, Gloucestershire, United Kingdom.

The need for interoperability of healthcare Information Technology (IT) systems in order to provide safe, efficient, and coordinated healthcare is universally recognized. Various health economies, such as the United Kingdom, the United States, and Australia, are seeking to develop regional, state-wide, or national systems of healthcare interoperability. In England, the community pharmacy network is a significant health provider, with important implications for provision of healthcare in deprived areas because of its accessibility. Read More

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November 2018
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Psychometric Properties of a Modified Moral Injury Questionnaire in a Military Population.

Traumatology (Tallahass Fla) 2018 Dec 3;24(4):301-312. Epub 2018 May 3.

Center on Alcoholism, Substance Abuse, & Addictions, University of New Mexico.

Moral injury (MI) results from perpetration of or exposure to distressing events, known as morally injurious events (MIEs), that challenge moral beliefs and values. Due to the type of involvement in recent military conflicts, many veterans report MIEs that may cause dissonance and, in turn, MI. Although two existing measures assess MIEs, neither currently assesses the defining characteristics of MI (i. Read More

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December 2018

Managing stake and accountability in Prime Ministers' accounts of the "refugee crisis": A longitudinal analysis.

J Community Appl Soc Psychol 2018 Nov-Dec;28(6):406-429. Epub 2018 Nov 8.

Department of Social Research University of Helsinki Helsinki Finland.

Taking a (critical) discursive psychological approach, the present study explores the identity management of the Finnish and Swedish Prime Ministers (PM) in relation to the "refugee crisis" and their countries' asylum policies. By taking a longitudinal approach and analysing the PMs' accounts of the "refugee crisis" from 1-year period, we focused on the ways rhetorical devices related to ethos, logos, and pathos were used to manage the issues of stake and accountability, as well as on the ways in which categories were worked up to serve particular functions. Our comparative analysis demonstrated significant similarities in the Finnish and Swedish PMs' talk, especially with regard to the transfer from a discourse of pathos and ethos, describing refugees in terms of individualism and humaneness, to a discourse of logos, emphasizing rationality, justifying sharpened immigration policies, and homogenizing refugees. Read More

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November 2018

Estimating Recent Local Impacts of Sea-Level Rise on Current Real-Estate Losses: A Housing Market Case Study in Miami-Dade, Florida.

Popul Res Policy Rev 2018 26;37(6):871-895. Epub 2018 Jun 26.

2Environmental Health Sciences, Columbia University's Mailman School of Public Health, New York, NY USA.

Sea-Level Rise (SLR) Projections from the National Oceanic and Atmospheric Administration (NOAA) and the U.S. Army Corp of Engineers (USACE) indicate increasing, and imminent, risk to coastal communities from tidal flooding and hurricane storm surge. Read More

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Biographical articles in scientific literature: analysis of articles indexed in Web of Science.

Scientometrics 2018 5;117(3):1695-1719. Epub 2018 Oct 5.

Department of Quantitative and Qualitative Methods, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.

Biographical articles in scientific journals offer a platform for the commemoration of distinguished individuals from the world of science. Despite so important a role for the scientific community, research on biographical articles is scarce. To fill this gap, we have analyzed 190,350 biographical articles indexed in Web of Science, written by 251,908 authors in 1945-2014. Read More

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October 2018
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Intransitivity increases plant functional diversity by limiting dominance in drylands worldwide.

J Ecol 2019 Jan 14;107(1):240-252. Epub 2018 Jun 14.

Departamento de Biología y Geología, Física y Química Inorgánica, Escuela Superior de Ciencias Experimentales y Tecnología, Universidad Rey Juan Carlos, C/ Tulipán s/n, 28933 Móstoles, Spain.

1. Biotic interactions are key determinants of plant community structure. Indirect interactions such as intransitivity ( in the absence of competitive hierarchies among species) have been hypothesized to benefit diversity within plant communities. Read More

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January 2019

Overweight and obesity in preschool aged children and risk of mental health service utilization.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Objective: To determine if overweight or obesity in preschool-age children is associated with mental health service utilization in later childhood.

Subjects: Overall, 10,522 children 2 to <5 years, with no previous history of mental health service utilization, were identified from primary care electronic medical records (EMRs) across Ontario, Canada.

Methods: This was a retrospective longitudinal cohort study. Read More

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December 2018
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Determinants of environmental styrene exposure in Gulf coast residents.

J Expo Sci Environ Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Background: In a previous study of exposure to oil-related chemicals in Gulf coast residents, we measured blood levels of volatile organic compounds. Levels of styrene were substantially elevated compared to a nationally representative sample. We sought to identify factors contributing to these levels, given the opportunities for styrene exposure in this community. Read More

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December 2018

Normotensive non-dipping blood pressure profile does not predict the risk of chronic kidney disease progression.

Hypertens Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups. Read More

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December 2018

The role of the microbiota in infectious diseases.

Nat Microbiol 2019 Jan 13;4(1):35-45. Epub 2018 Dec 13.

Department of Internal Medicine, Infectious Diseases Division, University of Michigan Medical School, Ann Arbor, MI, USA.

The human body is colonized by a diverse community of microorganisms collectively referred to as the microbiota. Here, we describe how the human microbiota influences susceptibility to infectious diseases using examples from the respiratory, gastrointestinal and female reproductive tract. We will discuss how interactions between the host, the indigenous microbiota and non-native microorganisms, including bacteria, viruses and fungi, can alter the outcome of infections. Read More

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January 2019

Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL).

Sci Rep 2018 Dec 13;8(1):17578. Epub 2018 Dec 13.

Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center, Houston, TX, USA.

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. Read More

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December 2018

Physician-pharmacist collaborative practice and telehealth may transform hypertension management.

J Hum Hypertens 2018 Dec 13. Epub 2018 Dec 13.

Clinical Research Unit, Italian Institute of Telemedicine, Varese, Italy.

Community pharmacists play a crucial role in hypertension management and their intervention, mainly including education, medication monitoring, and reviewing, blood pressure (BP) measurement and cardiovascular risk factors tracking, have proved to enhance BP control and adherence to antihypertensive treatment. A multidisciplinary collaborative approach with the referring physician and a patient-centered model of care have been proved to be particularly effective for improving control of hypertension and promoting patients' health. The inclusion of telehealth in such model (the so-called telepharmacy) may expand the reach of the pharmacist's intervention and provide pharmacy operations and patient care at a distance with further benefits for hypertensive patients and their managing physicians. Read More

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December 2018

Immune checkpoint inhibitors: recent progress and potential biomarkers.

Exp Mol Med 2018 Dec 13;50(12):165. Epub 2018 Dec 13.

Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Read More

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December 2018

Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial.

BMJ 2018 Dec 13;363:k5094. Epub 2018 Dec 13.

Michigan Integrated Center for Health Analytics and Medical Prediction, Department of Internal Medicine and Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA.

Objective: To determine if using a parachute prevents death or major traumatic injury when jumping from an aircraft.

Design: Randomized controlled trial.

Setting: Private or commercial aircraft between September 2017 and August 2018. Read More

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December 2018

Facilitating Web-Based Collaboration in Evidence Synthesis (TaskExchange): Development and Analysis.

JMIR Res Protoc 2018 Dec 13;7(12):e188. Epub 2018 Dec 13.

School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Background: The conduct and publication of scientific research are increasingly open and collaborative. There is growing interest in Web-based platforms that can effectively enable global, multidisciplinary scientific teams and foster networks of scientists in areas of shared research interest. Designed to facilitate Web-based collaboration in research evidence synthesis, TaskExchange highlights the potential of these kinds of platforms. Read More

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December 2018

Examining the Effects of Mindful Eating Training on Adherence to a Carbohydrate-Restricted Diet in Type 2 Diabetes: the DELISH Study Protocol.

JMIR Res Protoc 2018 Sep 19. Epub 2018 Sep 19.

UCSF Osher Center for Integrative Medicine, Department of Medicine, University of California San Francisco, UCSF Osher Center for Integrative Medicine1545 Divisadero Street, 4th Floor, San Francisco, US.

Background: Diet patterns have a profound influence on glycemic control for individuals with type 2 diabetes (T2DM), and craving-related eating is an important obstacle to dietary adherence. A growing body of research suggests that carbohydrate-restricted (CR) diets can improve glycemic control and reduce medication dependence in T2DM. However, limited data speak to the effects of long-term adherence to CR diets. Read More

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September 2018

Website Analytics of a Google Ads Campaign for a Men's Mental Health Website: Comparative Analysis.

JMIR Ment Health 2018 Dec 13;5(4):e12428. Epub 2018 Dec 13.

College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, NS, Canada.

Background: Men with mental health and addictions problems seek information and help from health service providers and community support less often than women with such problems. Online health resources offer men rapid access to self-care recommendations and resources and anonymity; however, only a few websites are specifically developed for men. Headstrong - Taking Things Head-On was a community pharmacy and online health promotion initiative for men living with mental health and addictions problems. Read More

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December 2018
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HbA screening in the community: Lessons for safety and quality management of a point of care programme.

Prim Care Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Epidemiology and Biostatistics, School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Aim: To describe quality management processes and appropriate interpretation with respect to HbA point-of-care (POC) testing in a national diabetes and cardiovascular risk screening programme.

Methods: We compared HbA results from capillary blood, measured by the cobas b 101 (Roche Diagnostics) POC testing system, with results from venous blood measured by accredited laboratory analysers to inform national screening practice and a (separately-reported) randomised controlled trial. Difference plots and regressions were used to aid interpretation around 40 and 50mmol/mol, the cut-offs used to identify "pre-diabetes" and diabetes in New Zealand. Read More

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December 2018

Prediabetes Risk Evaluation Scoring System [PRESS]: A simplified scoring system for detecting undiagnosed Prediabetes.

Prim Care Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Department of Community Medicine, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objective: To develop a simplified scoring system for detecting undiagnosed prediabetes among healthy adult population of Haryana, India.

Material & Methods: This cross-sectional study was a household survey which involved 892 healthy adults >18year of age who were subjected to an oral glucose tolerance test. Sensitivity, specificity, positive and negative predictive value and area under the receiver operating characteristic (ROC) curve and the optimal cut off points for identifying undiagnosed prediabetes were calculated. Read More

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December 2018

A combined mono- and multi-turbine approach for fault indicator synthesis and wind turbine monitoring using SCADA data.

ISA Trans 2018 Dec 5. Epub 2018 Dec 5.

University Grenoble Alpes, CNRS, Grenoble INP, GIPSA-lab, F-38000 Grenoble, France. Electronic address:

The monitoring of wind turbines using SCADA data has received lately a growing interest from the fault diagnosis community because of the very low cost of these data, which are available in number without the need for any additional sensor. Yet, these data are highly variable due to the turbine constantly changing its operating conditions and to the rapid fluctuations of the environmental conditions (wind speed and direction, air density, turbulence, …). This makes the occurrence of a fault difficult to detect. Read More

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December 2018

Incidence of oxandrolone induced hepatic transaminitis in patients with burn injury.

Burns 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, United States. Electronic address:

The benefits of oxandrolone in burn patients has led to its accepted use in the burn care community, however details regarding the most common adverse effect, transaminitis, remains unclear. The purpose of this study was to determine the incidence of transaminitis in patients with burn injury and identify risk factors associated with the development of transaminitis. This single-center, retrospective risk factor analysis compared burn patients on oxandrolone with and without the development of transaminitis, defined as any aspartate aminotransferase or alanine aminotransferase value >100mg/dL. Read More

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December 2018

Environmental characteristics of a tundra river system in Svalbard. Part 1: Bacterial abundance, community structure and nutrient levels.

Sci Total Environ 2018 Nov 28. Epub 2018 Nov 28.

Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza St., Gdansk 80-233, Poland. Electronic address:

The Arctic hosts a set of unique ecosystems, characterised by extreme environmental conditions and undergoing a rapid change resulting from the average temperature rising. We present a study on an aquatic ecosystem of the Revelva catchment (Spitsbergen), based on samples collected from the lake, river and their tributaries, in the summer of 2016. The landscape variety of the study site and the seasonal change in the hydrological regime modify the availability of nutrients. Read More

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November 2018
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