522,585 results match your criteria Communicative & integrative biology[Journal]


My patients prepared me well.

Authors:
Meagan E Brennan

Med J Aust 2019 Feb;210(3):115-116.e1

University of Sydney, Sydney, NSW.

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http://dx.doi.org/10.5694/mja2.13003DOI Listing
February 2019

Characterizing Perceptions Around the Patient-Oncologist Relationship: a Qualitative Focus Group Analysis.

J Cancer Educ 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The purpose of the current study was to characterize the experiences of cancer patients and their caregiver/family members around their relationship with their oncologist, health care team, and the hospital environment. Participants were recruited from The Ohio State University Comprehensive Cancer Center. Participant sociodemographic factors were assessed. Read More

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http://dx.doi.org/10.1007/s13187-019-1481-6DOI Listing
February 2019

Adolescent males' responses to blu's fake warnings.

Tob Control 2019 Feb 16. Epub 2019 Feb 16.

Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, USA.

Objective: Blu's 'Something Better' advertising campaign ran in popular print magazines in 2017. The campaign included advertisements with fake warnings conveying positive messages, which mimicked the Food and Drug Administration (FDA)'s warning requirements for electronic cigarette (e-cigarette) advertisements that took effect in 2018. We report adolescent males' recall of these fake warnings and how exposure to fake warnings affected recall of other advertisement components, including the actual warning or health risks, brand and product. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054805DOI Listing
February 2019

Short Communication: Discovery and molecular docking simulation of 7-hydroxy-6-methoxy-2H-chromen-2-one as a LOX Inhibitor.

Pak J Pharm Sci 2019 Jan;32(1):217-220

International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Millettia ovalifolia is traditionally used in variety of diseases including inflammation. In our investigation in to the phytochemical constituents of Millettia ovalifolia an effort was made to find out bioactive constituent from medicinal Plant M. ovalifolia to scientifically validate its use in inflammatory disorders. Read More

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January 2019

Quantifying correlations between mutational sites in the catalytic subunit of γ-secretase.

J Mol Graph Model 2019 Feb 8;88:221-227. Epub 2019 Feb 8.

Facultad de Química, Departamento de Fisicoquímica, Universidad Nacional Autónoma de México, CDMX, México, 04510, Mexico. Electronic address:

Presenilin 1 (PS1) is the catalytic subunit of the γ-secretase complex which is involved in the generation of amyloid-β peptides (Aβ). Single point mutations in PS1 alter the cleavage pattern of the amyloid precursor protein (APP) and lead to the formation of aberrant Aβ peptides. To date, more than two hundred mutations distributed among almost a third of PS1's amino acids have been associated to the development of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.jmgm.2019.02.002DOI Listing
February 2019

Mucoepidermoid carcinoma of the head and neck in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 10;120:93-99. Epub 2019 Feb 10.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, Boston, MA, 02115, United States; Department of Otolaryngology, Harvard Medical School, Boston, MA, 02115, United States. Electronic address:

Introduction: Mucoepidermoid carcinoma is a rare malignant salivary gland neoplasm in the pediatric population. Few studies have discussed best practice with respect to diagnosis and treatment in children.

Objective: To present our institution's experience with the evaluation and management of pediatric mucoepidermoid carcinoma of the head and neck. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.020DOI Listing
February 2019

Receptive and productive speech and language abilities in hearing-impaired children with German as a second language.

Int J Pediatr Otorhinolaryngol 2019 Feb 6;120:100-107. Epub 2019 Feb 6.

University of Applied Sciences, Alter Teichweg 19, 22081, Hamburg, Germany. Electronic address:

Objectives: Many studies examining early bilingualism in migrant populations focus on the development of the first language. As language acquisition is closely related to the hearing development, there is a critical need to investigate language development in hearing-impaired children being raised bilingually who were fitted with cochlear implants and/or hearing aids. Therefore, this research project aimed to study the linguistic development of hearing-impaired children being raised with German as a second language who were provided with hearing aids or cochlear implants. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.012DOI Listing
February 2019

Regulation of the pleiotropic effects of tissue resident mast cells.

J Allergy Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, D-70599 Stuttgart, Germany. Electronic address:

Mast cells, best known for their detrimental role in allergic diseases, act in a diverse array of physiological and pathological functions, made possible by the plurality of mast cell types. Their various developmental avenues and their distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow mast cells to communicate with their environment to fulfill their tasks, discuss their protease repertoire stored in secretory lysosomes, and consider different aspects of mast cell signaling. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.004DOI Listing
February 2019

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity.

Cell Syst 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

The immune system generates pathogen-tailored responses. The precise innate immune cell types and pathways that direct robust adaptive immune responses have not been fully characterized. By using fluorescent pathogens combined with massively parallel single-cell RNA-seq, we comprehensively characterized the initial 48 h of the innate immune response to diverse pathogens. Read More

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http://dx.doi.org/10.1016/j.cels.2019.01.001DOI Listing
February 2019

How should sugar-sweetened beverage health warnings be designed? A randomized experiment.

Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, NC, United States of America.

Health warnings are a promising strategy for reducing consumption of sugar-sweetened beverages (SSBs), but uncertainty remains about how to design warnings to maximize their impact. Warnings already implemented in Latin America use nutrient disclosures, while proposed U.S. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.010DOI Listing
February 2019

The Relationship Between Hearing Loss and Substance Use Disorders Among Adults in the U.S.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

VA Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, Ann Arbor, Michigan; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.

Introduction: Hearing loss is common and associated with poorer health and impeded communication. Little is known about the association between hearing loss and substance use disorders in the general population. The objective of this study was to assess substance use disorder prevalence among individuals with hearing loss, versus those without hearing loss, in a nationally representative sample of adults. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.026DOI Listing
February 2019

National Trends in Human Papillomavirus Awareness and Knowledge of Human Papillomavirus-Related Cancers.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Behavioral Research Program, National Cancer Institute, Bethesda, Maryland.

Introduction: The President's Cancer Panel released a report in 2014 calling for communication strategies to promote the human papillomavirus vaccine among males and females. The purpose of this study was to (1) estimate changes in human papillomavirus awareness and knowledge of human papillomavirus-related cancers from 2014 to 2017 using a nationally representative survey of adults in the U.S. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.11.005DOI Listing
February 2019

Impact of Perceived Racism on Healthcare Access Among Older Minority Adults.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Social and Behavioral Sciences Department, Yale School of Public Health, New Haven, Connecticut; Department of Psychology, Graduate School of Arts and Sciences, Yale University, New Haven, Connecticut.

Introduction: Older minority individuals are less likely to receive adequate health care than their white counterparts. This study investigates whether perceived racism is associated with delayed/forgone care among minority older adults, and whether poor doctor communication mediates this relationship.

Methods: Study cohort consisted of minority participants, aged ≥65 years, in the 2015 California Health Interview Survey (N=1,756). Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.010DOI Listing
February 2019

Impact of specialized pediatric palliative care programs on communication and decision-making.

Patient Educ Couns 2019 Feb 11. Epub 2019 Feb 11.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Canada.

Objective: To summarize and analyze the impact of specialized pediatric palliative care (SPPC) programs on communication and decision-making for children with life-threatening conditions.

Methods: Our search strategy covered MEDLINE, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, Scopus, and Embase through September 2018.

Results: We reviewed 13 studies analyzing the impact of SPPC programs on communication and decision-making using a wide range of outcome indicators. Read More

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http://dx.doi.org/10.1016/j.pec.2019.02.011DOI Listing
February 2019

Effect of pre-maturation with C-type natriuretic peptide and 3-isobutyl-1-methylxanthine on cumulus-oocyte communication and oocyte developmental competence in cattle.

Anim Reprod Sci 2019 Jan 25. Epub 2019 Jan 25.

Robinson Research Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, 5005, Australia; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, 5005, Australia; Australian Research Council Centre of Excellence for Nanoscale BioPhotonics and Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, South Australia, 5005, Australia. Electronic address:

In vitro embryo production depends on oocyte competence, which is acquired during folliculogenesis, involving cytoplasmic and nuclear processes. In vitro maturation (IVM) induces spontaneous resumption of meiosis, preventing full competence acquisition. The incorporation of a pre-IVM phase with supplementation with C-type natriuretic peptide (CNP) and 3-Isobutyl-1-methylxanthine (IBMX) was used with the aim of improving developmental competence of cattle oocytes. Read More

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http://dx.doi.org/10.1016/j.anireprosci.2019.01.007DOI Listing
January 2019

Robust optimal predictive control of heavy haul train under imperfect communication.

ISA Trans 2019 Feb 7. Epub 2019 Feb 7.

State Key Laboratory of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China; School of Electronics and Information Engineering, Beijing Jiaotong University, Beijing 100044, China.

With the rapid developments in communication technology, the bidirectional wireless communication channel is widely used to exchange information between the train and wayside control center. As an emerging technology, the communication based heavy haul train control (CBHHTC) system is becoming a better alternative for administrative department to provide the greater transport capacity. In order to put the latest automatic control methods into the practice, this paper investigates the robust optimal control problem of heavy haul train under CBHHTC. Read More

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http://dx.doi.org/10.1016/j.isatra.2019.01.029DOI Listing
February 2019

Calf care personnel on dairy farms and their educational opportunities.

J Dairy Sci 2019 Feb 13. Epub 2019 Feb 13.

College of Veterinary Medicine, Washington State University, Pullman 99164.

As dairy herd sizes become larger and the organization of the business more complex, targeting communication and education to enhance animal care becomes more difficult. The purpose of this study was to describe selected demographics of calf care employees on large (>500 animals) and small (<501 animals) dairy farms that raise their own calves. Two to 8 individuals per farm involved with calf care, including owners, veterinarians, and calf managers, feeders, and treaters, were interviewed in either English or Spanish. Read More

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http://dx.doi.org/10.3168/jds.2018-15401DOI Listing
February 2019

Zika and travel in the news: a content analysis of US news stories during the outbreak in 2016-2017.

Public Health 2019 Feb 13. Epub 2019 Feb 13.

RTI International, P.O. Box 12194, Research Triangle Park, NC, USA. Electronic address:

Objectives: This study aimed to understand what information the US media communicated about Zika virus (ZIKV) and travel in 2016 and 2017.

Study Design: We conducted a content analysis of news coverage about ZIKV and travel from April 5, 2016 to March 31, 2017.

Methods: We obtained a stratified, random sample of English language, US print newspaper and television news coverage about ZIKV and travel. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.009DOI Listing
February 2019

The importance of non-technical skills in modern surgical practice.

Cir Esp 2019 Feb 13. Epub 2019 Feb 13.

Hospital del Trabajador, Santiago, Chile.

The significance of technical skills and manual dexterity for surgeons is an indisputable fact. However, the systematic study of medical errors has revealed that a significant percentage of these errors are caused by factors related to non-technical skills. The review presented in this article intends to describe and explore the relevance of these non-technical skills, including: situational awareness, decision-making, leadership and communication. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.12.007DOI Listing
February 2019

Phosphinate-based mitochondria-targeted fluorescent probe for imaging and detection of endogenous superoxide in live cells and in vivo.

Talanta 2019 May 2;197:239-248. Epub 2019 Jan 2.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Science, 100190 Beijing, China. Electronic address:

Monitoring superoxide anion radical (O) in live cells and in vivo is of great significance since O is the precursor of other reactive oxygen species and has been closely associated with various physiological and pathological processes. Herein, we developed a novel mitochondria-targeted fluorescent probe PF-MitoSOX Green in which the phosphinate moiety is utilized to recognize O with high sensitivity and selectivity. Confocal imaging results illustrated that PF-MitoSOX Green can not only detect intracellular O, but also can conveniently visualize its production in cells and Caenorhabditis elegans. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.12.080DOI Listing

[Complementary and alternative medicine use in two French pediatric oncology centers: A common practice].

Bull Cancer 2019 Feb 13. Epub 2019 Feb 13.

CHU de Nantes, service d'onco-hématologie pédiatrique, 44093 Nantes, cedex France. Electronic address:

Background: The use of complementary and alternative medicine (CAM) in children with cancer is commonly used. However, studies and data on this topic are still scarce in France.

Methods: Our aim was to investigate the prevalence of CAM usage in pediatric cancer patients and describe the modality of use. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.11.017DOI Listing
February 2019

[Prevention, the position and actions of the healthcare professional].

Authors:
Pedro Conches

Soins 2019 Jan - Feb;64(832):31-34

Délégation territoriale de l'Yonne, 3, rue Jehan-Pinard, 89010 Auxerre cedex, France. Electronic address:

All healthcare professionals have a role to play in prevention. This consists in raising patients' awareness and providing them with suitable support. There are numerous levers of which the risks and benefits must be assessed. Read More

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http://dx.doi.org/10.1016/j.soin.2018.12.007DOI Listing

An analysis of conservation practice adoption studies in agricultural human-natural systems.

J Environ Manage 2019 Feb 13;236:490-498. Epub 2019 Feb 13.

Indiana University, Department of Geography, USA.

Farmers' conservation decisions are central to addressing regional environmental challenges, such as biodiversity loss, water quality impairment, or climate change. However, three decades of substantial investment in agri-environmental programs has not yielded widespread adoption or improved environmental outcomes. It remains difficult to explain why farmers adopt despite an extensive body of research on the topic. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.009DOI Listing
February 2019

A pilot investigation of neuroimaging predictors for the benefits from pivotal response treatment for children with autism.

J Psychiatr Res 2019 Feb 5;111:140-144. Epub 2019 Feb 5.

Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA. Electronic address:

Children with autism spectrum disorder (ASD) frequently exhibit language delays and functional communication deficits. Pivotal response treatment (PRT) is an effective intervention for targeting these skills; however, similar to other behavioral interventions, response to PRT is variable across individuals. Thus, objective markers capable of predicting treatment response are critically-needed to identify which children are most likely to benefit from this intervention. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.001DOI Listing
February 2019

Migrant Polish women overcoming communication challenges in Scottish maternity services: A qualitative descriptive study.

Midwifery 2019 Feb 7;72:30-38. Epub 2019 Feb 7.

School of Nursing and Midwifery, Robert Gordon University, Garthdee Road, Aberdeen AB10 7AQ, UK.

Background: Migrant women are more likely to experience sub-optimal maternity outcomes and are often described in a problematised way. Communication is crucial in maternity and can be compromised if the language of that service is delivered in a language incomprehensible to migrant women.

Methods: Qualitative descriptive study using 9 in-depth individual interviews with Polish women who recently had experience of local maternity services. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.004DOI Listing
February 2019

Mobile obstetric and neonatal simulation based skills training in India.

Midwifery 2019 Feb 7;72:14-22. Epub 2019 Feb 7.

Department of Paediatrics, Monash University, Melbourne, Australia.

Background: The developing world has a significantly high risk of women and babies dying during childbirth. Interprofessional simulation training has improved birth practices and outcomes by impacting clinical and non-technical skills like communication, teamwork, leadership and effective use of resources. While these programs have become a training requirement in many high-income countries, they have not been widely introduced in the low-income, low-resource settings. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.006DOI Listing
February 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019
2.998 Impact Factor

Visual and action-control expressway associated with efficient information transmission in elite athletes.

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China. Electronic address:

Effective information transmission for open skill performance requires fine-scale coordination of distributed networks of brain regions linked by white matter tracts. However, how patterns of connectivity in these anatomical pathways may improve global efficiency remains unclear. In this study, we hypothesized that the feeder edges in visual and motor systems have the potential to become "expressways" that increase the efficiency of information communication across brain networks of open skill experts. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.006DOI Listing
February 2019
3.357 Impact Factor

Forms of extracellular mitochondria and their impact in health.

Mitochondrion 2019 Feb 13. Epub 2019 Feb 13.

Universidad San Francisco de Quito, Colegio de Ciencias de la Salud - Hospital de los Valles, Escuela de Medicina, Quito 17-12-841, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina, Quito 17-12-841, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Sistemas Médicos - Universidad San Francisco de Quito, SIME-USFQ, Quito 17-12-841, Ecuador. Electronic address:

Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.002DOI Listing
February 2019

The representation of symmetry in multi-voxel response patterns and functional connectivity throughout the ventral visual stream.

Neuroimage 2019 Feb 13. Epub 2019 Feb 13.

Brain and Cognition, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium. Electronic address:

Several computational models explain how symmetry might be detected and represented in the human brain. However, while there is an abundance of psychophysical studies on symmetry detection and several neural studies showing where and when symmetry is detected in the brain, important questions remain about how this detection happens and how symmetric patterns are represented. We studied the representation of (vertical) symmetry in regions of the ventral visual stream, using multi-voxel pattern analyses (MVPA) and functional connectivity analyses. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.030DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

The importance of non-technical performance for teams managing postpartum haemorrhage: video review of 99 obstetric teams.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

School of Applied Psychology, University of Applied Sciences and Arts Northwestern Switzerland, Switzerland.

Objective: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage.

Design: Video review - observational study.

Setting: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. Read More

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http://dx.doi.org/10.1111/1471-0528.15655DOI Listing
February 2019

Development of a clinical practice guideline for orthodontic retention.

Orthod Craniofac Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Dentistry, section of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: To develop a clinical practice guideline (CPG) for orthodontic retention (OR).

Materials And Methods: The CPG was developed according to the AGREE II instrument and EBRO (Dutch methodology for evidence-based guideline development). Reporting was done according the RIGHT statement. Read More

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http://dx.doi.org/10.1111/ocr.12302DOI Listing
February 2019

Success Factors Enabling Employment for Adults on the Autism Spectrum from Employers' Perspective.

J Autism Dev Disord 2019 Feb 15. Epub 2019 Feb 15.

School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.

Employment outcomes for individuals with autism spectrum disorder (ASD) are poor and there is limited understanding on how best to support individuals with ASD in the workplace. Stakeholders involved in the employment of adults with ASD, including employers and employment service providers have unique insights into the factors influencing employment for this population. Organisational and individual factors facilitating successful employment for adults with ASD across Australia and Sweden were explored, including the supports and strategies underpinning employment success from an employers' perspective. Read More

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http://dx.doi.org/10.1007/s10803-019-03923-3DOI Listing
February 2019

Assessing sustainable effectiveness of the adjustment mechanism of a ubiquitous clinic recommendation system.

Health Care Manag Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Industrial Engineering and Management, National Chiao Tung University, 1001 University Road, Hsinchu, Taiwan.

Advances in computer and communication technologies have engendered opportunities for developing an improved ubiquitous health care environment. One of the crucial applications is a ubiquitous clinic recommendation system, which entails recommending a suitable clinic to a mobile patient based on his/her location, hospital department, and preferences. However, patients may not be willing or able to express their preferences. Read More

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http://dx.doi.org/10.1007/s10729-019-09473-5DOI Listing
February 2019

Perianal sepsis: surgical perspective and practical MRI reporting for radiologists.

Abdom Radiol (NY) 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Concord Repatriation General Hospital, Concord Clinical School, Sydney Medical School, University of Sydney, Concord, NSW, 2137, Australia.

This article describes the development of a structured MRI reporting template and diagrammatic worksheet for perianal sepsis through collaboration between radiologists and colorectal surgeons at our institution, and the rationale behind each component of the worksheet. Benefits of this reporting worksheet include optimizing communication of key imaging findings that have a real impact on patient management, less time spent on reporting the study, and easier comparison between studies. We illustrate the utility of the report template with case studies. Read More

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http://dx.doi.org/10.1007/s00261-019-01920-9DOI Listing
February 2019

Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Nat Rev Immunol 2019 Feb 15. Epub 2019 Feb 15.

Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Read More

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http://dx.doi.org/10.1038/s41577-019-0131-xDOI Listing
February 2019

Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To determine the prevalence of limited health literacy in parents of infants born ≤32 and 0/7 weeks and if health literacy changes during hospitalization.

Study Design: Multi-site, prospective cohort study measuring health literacy using the Parent Health Literacy Activities Test, which estimates caregivers' ability to complete tasks such as reading prescription labels and preparing bottles. Data were analyzed using parametric and nonparametric comparison tests and multivariable regression to control for confounders. Read More

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http://dx.doi.org/10.1038/s41372-019-0340-yDOI Listing
February 2019

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

Nat Commun 2019 Feb 15;10(1):883. Epub 2019 Feb 15.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08800-2DOI Listing
February 2019

A co-produced method to involve service users in research: the SUCCESS model.

BMC Med Res Methodol 2019 Feb 15;19(1):34. Epub 2019 Feb 15.

Centre for Innovative Ageing, College of Human and Health Science, Swansea University, Swansea, UK.

Background: Public and patient involvement is a routine element of health services research methods to produce better designed and reported studies. Although co-production is recommended when involving people in research, methods for involving people are usually designed and managed by researchers and there is little evidence about methods to co-produce models for effective public and patient involvement. We report the method used by a group of patient and carer service users to develop and implement a model for involving public members in research. Read More

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http://dx.doi.org/10.1186/s12874-019-0671-6DOI Listing
February 2019

Genetic interactions support an inhibitory relationship between bone morphogenetic protein 2 and netrin 1 during semicircular canal formation.

Development 2019 Feb 15;146(4). Epub 2019 Feb 15.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, MD 20892, USA

The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving behind the region at the rim to form a tube-shaped canal. Lack of proliferation at the rim and/or over-clearing of epithelial cells in the center of the pouch can obliterate canal formation. Otic-specific knockout of bone morphogenetic protein 2 () results in absence of all three semicircular canals; however, the common crus and ampullae housing the sensory tissue (crista) are intact. Read More

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http://dx.doi.org/10.1242/dev.174748DOI Listing
February 2019

Value and Barriers to Use of the SIMPL Tool for Resident Feedback.

J Surg Educ 2019 Feb 12. Epub 2019 Feb 12.

University of Kentucky, Department of Surgery, Lexington, Kentucky. Electronic address:

Objective: The System for Improving and Measuring Procedural Learning (SIMPL) is a smart-phone application used to provide residents with an evaluation of operative autonomy and feedback. This study investigated the perceived benefits and barriers to app use.

Design: A database of previously performed SIMPL evaluations was analyzed to identify high, low, and never users. Read More

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http://dx.doi.org/10.1016/j.jsurg.2019.01.012DOI Listing
February 2019

Cortical Areas Interact through a Communication Subspace.

Neuron 2019 Feb 7. Epub 2019 Feb 7.

Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

Most brain functions involve interactions among multiple, distinct areas or nuclei. For instance, visual processing in primates requires the appropriate relaying of signals across many distinct cortical areas. Yet our understanding of how populations of neurons in interconnected brain areas communicate is in its infancy. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.01.026DOI Listing
February 2019

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.

Immunity 2019 Feb 5. Epub 2019 Feb 5.

Department of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Elevated glucose metabolism in immune cells represents a hallmark feature of many inflammatory diseases, such as sepsis. However, the role of individual glucose metabolic pathways during immune cell activation and inflammation remains incompletely understood. Here, we demonstrate a previously unrecognized anti-inflammatory function of the O-linked β-N-acetylglucosamine (O-GlcNAc) signaling associated with the hexosamine biosynthesis pathway (HBP). Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.007DOI Listing
February 2019

Goals-of-Care Conversations for Older Adults With Serious Illness in the Emergency Department: Challenges and Opportunities.

Ann Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Division of Palliative Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Division of Palliative Medicine, Brigham and Women's Hospital, Boston, MA.

During the last 6 months of life, 75% of older adults with preexisting serious illness, such as advanced heart failure, lung disease, and cancer, visit the emergency department (ED). ED visits often mark an inflection point in these patients' illness trajectories, signaling a more rapid rate of decline. Although most patients are there seeking care for acute issues, many of them have priorities other than to simply live as long as possible; yet without discussion of preferences for treatment, they are at risk of receiving care not aligned with their goals. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.01.003DOI Listing
February 2019

Patient preferences on the use of technology in cancer surveillance after curative surgery: A cross-sectional analysis.

Surgery 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus. Electronic address:

Background: Advances in communication technology have enabled new methods of delivering test results to cancer survivors. We sought to determine patient preferences regarding the use of newer technology in delivering test results during cancer surveillance.

Methods: A single institutional, cross-sectional analysis of the preferences of adult cancer survivors regarding the means (secure digital communication versus phone call or office visit) to receive surveillance test results was undertaken. Read More

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http://dx.doi.org/10.1016/j.surg.2018.12.021DOI Listing
February 2019

A Fast Indoor/Outdoor Transition Detection Algorithm Based on Machine Learning.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

School of Software Engineering, Beijing University of Posts and Telecommunication, Beijing 100876, China.

The widespread popularity of smartphones makes it possible to provide Location-Based Services (LBS) in a variety of complex scenarios. The location and contextual status, especially the Indoor/Outdoor switching, provides a direct indicator for seamless indoor and outdoor positioning and navigation. It is challenging to quickly detect indoor and outdoor transitions with high confidence due to a variety of signal variations in complex scenarios and the similarity of indoor and outdoor signal sources in the IO transition regions. Read More

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http://dx.doi.org/10.3390/s19040786DOI Listing
February 2019

Optimal Energy-Delay in Energy Harvesting Wireless Sensor Networks with Interference Channels.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom,Hong Kong, China.

In this work, we investigate the capacity allocation problem in the energy harvesting wireless sensor networks (WSNs) with interference channels. For the fixed topologies of data and energy, we formulate the optimization problem when the data flow remains constant on all data links and each sensor node harvests energy only once in a time slot. We focus on the optimal data rates, power allocations and energy transfers between sensor nodes in a time slot. Read More

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http://dx.doi.org/10.3390/s19040785DOI Listing
February 2019

Incremental Adjustments to Amount of Thickening Agent in Beverages: Implications for Clinical Practitioners Who Oversee Nutrition Care Involving Thickened Liquids.

Foods 2019 Feb 14;8(2). Epub 2019 Feb 14.

Center for Sensory Analysis and Consumer Behavior, 1310 Research Park Dr., Manhattan, KS 66502, USA.

This study examined the changes in viscosity in response to small alterations in the amount of a thickening agent mixed with three commonly thickened beverages. A total of 11 incremental adjustments in the amount of a starch-based thickening agent (5.0 g to 7. Read More

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http://dx.doi.org/10.3390/foods8020074DOI Listing
February 2019
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