Antibody deficiency in patients with frequent exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
- Brian N McCullagh,
- Alejandro P Comellas,
- Zuhair K Ballas,
- John D Newell,
- M Bridget Zimmerman,
- Antoine E Azar
PLoS One 2017 17;12(2):e0172437. Epub 2017 Feb 17.
Division of Allergy and Clinical Immunology, Department of Internal Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Chronic Obstructive Pulmonary Disease is the third leading cause of death in the US, and is associated with periodic exacerbations, which account for the largest proportion of health care utilization, and lead to significant morbidity, mortality, and worsening lung function. A subset of patients with COPD have frequent exacerbations, occurring 2 or more times per year. Despite many interventions to reduce COPD exacerbations, there is a significant lack of knowledge in regards to their mechanisms and predisposing factors. Read More