941,721 results match your criteria Combined Modality Molecular Targeted Therapy Head Neck Squamous Cell Carcinoma


[Implementation of telemedicine in daily care of urological patients].

Aktuelle Urol 2018 Dec 6;49(6):509-514. Epub 2018 Dec 6.

Universitätsklinikum Köln, Klinik für Urologie, Uro-Onkologie, spezielle urologische und roboter-assistierte Chirurgie, Köln.

Due to demographic changes and aging in the German population combined with the shortage of doctors, new techniques are needed to ensure urological patient care in the future. Telemedicine offers great potential to facilitate patient monitoring in their familiar surroundings and to ameliorate patient's compliance with the suggested therapy concept. Through optimal and reliable transfer of patient data, telemedicine helps to optimise patient satisfaction with urological therapies, binds them to their doctor and raises diagnostic safety. Read More

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December 2018
6 Reads

Predicted short and long-term impact of deworming and water, hygiene, and sanitation on transmission of soil-transmitted helminths.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006758. Epub 2018 Dec 6.

Research School of Population Health, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australian Capital Territory, Australia.

Background: Regular preventive chemotherapy (PCT) targeting high-risk populations is an effective way to control STH in the short term, but sustainable long-term STH control is expected to require improved access to water, sanitation, and hygiene (WASH). However, experimental studies have not been able to conclusively demonstrate the benefit of WASH in preventing STH (re-)infections. We investigated the impact of WASH on STH infections during and after PCT using mathematical modelling. Read More

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December 2018
2 Reads

Clinical Drug Response Prediction by Using a Lq Penalized Network-Constrained Logistic Regression Method.

Cell Physiol Biochem 2018 Dec 6;51(5):2073-2084. Epub 2018 Dec 6.

Faculty of Information Technology & State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.

Background/aims: One of the most important impacts of personalized medicine is the connection between patients' genotypes and their drug responses. Despite a series of studies exploring this relationship, the predictive ability of such analyses still needs to be strengthened.

Methods: Here we present the Lq penalized network-constrained logistic regression (Lq-NLR) method to meet this need, in which the predictors are integrated into the gene expression data and biological network knowledge and are combined with a more aggressive penalty function. Read More

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December 2018
2 Reads

A label-free impedimetric aptasensor for the detection of Bacillus anthracis spore simulant.

Biosens Bioelectron 2018 Nov 15;126:640-646. Epub 2018 Nov 15.

Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy. Electronic address:

Herein, we report an impedimetric DNA-based aptamer sensor for a single-step detection of B. anthracis spore simulant (B. cereus spore). Read More

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November 2018
2 Reads

Management of slurry in Gran Canaria Island with full-scale natural treatment systems for wastewater (NTSW). One year experience in livestock farms.

J Environ Manage 2018 Dec 3;232:666-678. Epub 2018 Dec 3.

Institute for Environmental Studies and Natural Resources (i-UNAT), University of Las Palmas de Gran Canaria, Spain. Electronic address:

The aim of this work is to describe the performance of three full-scale natural treatment systems for wastewater, which operated in an integrated manner in livestock pig farms (1000-1500pigsintotal) over one year. Slurry management was performed with these natural treatment systems operating under the normal waste loading conditions of the livestock farms in which were integrated. The systems were comprised of elements such as first generation digesters, subsurface flow constructed wetlands and facultative ponds. Read More

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December 2018
1 Read

Synergistic Activity of Paclitaxel, Sorafenib, and Radiation Therapy in advanced Renal Cell Carcinoma and Breast Cancer.

Transl Oncol 2018 Dec 3;12(2):381-388. Epub 2018 Dec 3.

Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, South Korea; Department of Surgery, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. Electronic address:

Advanced cancer has been shown to be associated with a higher percentage of epigenetic changes than with genetic mutations. Preclinical models have shown that the combination of paclitaxel, sorafenib, and radiation therapy (RT) plays a crucial role in renal cell carcinoma (RCC) and breast cancer. This study aimed to investigate the involvement of mitochondrial cytochrome c-dependent apoptosis in the mechanism of action of a combination of paclitaxel, sorafenib, and RT in RCC and breast cancer. Read More

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December 2018
1 Read

Full length foot orthoses have an immediate treatment effect and modify gait of children with idiopathic toe walking.

Gait Posture 2018 Nov 20;68:227-231. Epub 2018 Nov 20.

Monash University, School of Primary and Allied Health Care, Frankston, VIC, 3199, Australia; Peninsula Health, Allied Health, 4 Hastings Rd, Frankston, VIC, 3199, Australia.

Background: There remains a substantial lack of evidence to support the use of foot orthoses as a conservative treatment option for idiopathic toe walking (ITW). Encouraging heel contact during gait is one of the primary goals of most interventions in paediatric ITW.

Research Question: Does the combined treatment of high-top boots and orthoses increase the number of heel contacts during gait and change spatio-temporal gait parameters?

Methods: This within subject designed randomised controlled trial recruited fifteen children diagnosed with ITW (n = 10 males). Read More

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November 2018
2 Reads

Food up-take and reproduction performance of Daphnia magna under the exposure of Bisphenols.

Ecotoxicol Environ Saf 2018 Dec 3;170:47-54. Epub 2018 Dec 3.

Key laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) & School of Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Because the application of Bisphenol A (BPA) was restricted, many substitutes, such as Bisphenol F (BPF) and Bisphenol S (BPS), were developed as BPA substitutes. Therefore, environmental impacts of BPA and its substitutes on aquatic organisms should be concerned, especially their combined toxicity. In this study, the impacts of BPA, BPF, BPS and their mixture on the feeding behavior, reproduction and physiological function of daphnids were synthetically evaluated, involving the duration and mode of exposure. Read More

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December 2018
3 Reads

Combined juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia (JPS/HHT) with MRI and endoscopic correlation.

Clin Imaging 2018 Dec 2;54:37-39. Epub 2018 Dec 2.

Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.

Juvenile polyposis syndrome (JPS) may coexist with hereditary hemorrhagic telangiectasia (HHT) due to implication of the SMAD4 gene in a subset of both diseases. To the best of our knowledge, we present the first case in the radiologic literature on the MRI findings in a patient with this rare combined diagnosis undergoing workup for burden of disease. Read More

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December 2018
2 Reads

Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Major depressive disorders impact approximately 17% of the population worldwide, whose high morbidity and considerable adversity have resulted in enormous social and economic burden. In addition, clinically depressed patients often show reduced volume of olfactory bulb (OB) and decreased olfactory sensitivity. Although mounting evidence conveyed that the gut microbiota may implicate the pathophysiology of major depressive disorder (MDD) via the microbe-gut-brain axis, knowledge about its distinctive molecular mechanism is rudimentary. Read More

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December 2018
2 Reads

Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Drug resistance in bacteria is becoming a significant threat to global public health, and the development of novel and efficient antibacterial compounds is urgently needed. Recently, rhodium complexes have attracted attention as antimicrobial agents, yet their antibacterial mechanism remains unknown. In this study, we observed that the dirhodium (II) complex RhAc inhibited Streptococcus. Read More

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December 2018
1 Read

EGFR-mutant SCLC exhibits heterogeneous phenotypes and resistance to common antineoplastic drugs.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine, National Taiwan University Hospital, Taiwan. Electronic address:

Introduction: Approximately 5% of patients with EGFR-activating mutations acquire EGFR-TKIs resistance through SCLC transformation. However, the reason for the poor outcome and the molecular basis of EGFR-mutant SCLC that has transformed from adenocarcinoma remain unclear.

Methods: In this study, we established 2 EGFR-mutant SCLC cell lines from lung adenocarcinoma patients after failed EGFR-TKI treatment to investigate their molecular basis and potential therapeutic strategies in the hope of improving patient outcome. Read More

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December 2018
3 Reads

Posterior Extensive Circumferential Decompressive Reconstructive Technique in surgical treatment of Upper Thoracic Spine Compressive Lesions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedic Surgery and Traumatology and Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt; Minia University Spine Unit (MUSU), Faculty of Medicine, Minia University. Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt. Electronic address:

Background Data: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns.

Purpose: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure. Read More

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December 2018
2 Reads

Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies.

Neuroimage 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychology, Yale University, USA; Department of Neuroscience, Yale School of Medicine, USA; Interdepartmental Neuroscience Program, Yale University, USA.

Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. Read More

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December 2018

Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, GITAM University, Rushikonda, Visakapatnam 530045, Andhra Pradesh, India.

Rationale: Combined therapy is a promising approach over its preference to minimize the dose, adverse effects and enhanced therapeutic efficiency in a various diseases including diabetes.

Aim: The present research work is to explore combined synergistic anti-diabetic potential of chitosan and pectin with Metformin (CPM) nano-formulation, with special emphasis on effect of Metformin when integrated with bio polymers.

Methods: The biohybrid nanoparticles (CPMNP) were formulated by ionic gelation process. Read More

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December 2018
1 Read

Bioactivity of soy-based fermented foods: A review.

Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. Electronic address:

For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, fermented soy milk, Tempeh and soy sauce. Read More

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December 2018
1 Read

Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity.

Neurobiol Dis 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Functional Neurochemistry, IRCCS Mondino Foundation, Pavia, Italy. Electronic address:

GBA1 gene encode for the lysosomal membrane protein glucocerebrosidase (GCase). GBA1 heterozygous mutations profoundly impair GCase activity and are currently recognized as an important risk factor for the development of Parkinson's disease (PD). Deficits in lysosomal degradation pathways may contribute to pathological α-synuclein accumulation, thereby favoring dopaminergic neuron degeneration and associated microglial activation. Read More

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December 2018

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain.

J Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Instituto Biofisika (UPV/EHU, CSIC) y Dpto. de Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Barrio Sarriena S/N, 48490, Leioa, Spain. Electronic address:

Protein aggregate reactivation in metazoans is accomplished by the combined activity of Hsp70, Hsp40 and Hsp110 chaperones. Hsp110s support the refolding of aggregated polypeptides acting as specialized nucleotide exchange factors of Hsp70. We have studied how Apg2, one of the three human Hsp110s, regulates the activity of Hsc70 (HspA8), the constitutive Hsp70 in our cells. Read More

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December 2018

Ligand density and linker length are critical factors for multivalent nanoparticle-receptor interactions.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Although there is a large number of studies available evaluating the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different PEG spacer lengths (2/3.5/5kDa) and the specific receptor binding of targeted core-shell structured PLGA/PLA-PEG nanoparticles was evaluated using αβ integrin overexpressing U87MG glioblastoma cells. Read More

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December 2018
1 Read

[Complex fractures of the clavicles lateral third].

Acta Ortop Mex 2018 May-Jun;32(3):140-144

Módulo de Cirugía de Hombro y Codo, Hospital General Xoco. Av. México Coyoacán S/N, Col. General Anaya, Deleg. Benito Juárez, CP 03340, Ciudad de México, México.

Background: Fractures of the lateral third of the clavicle represent 18% of all clavicle fractures. Even though non-displaced fractures can be managed conservatively, displaced fractures have a non-union percentage of 30%. Multiple approaches have been proposed to manage the displaced fractures. Read More

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December 2018
2 Reads

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013190. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving survival; however, anxiety around missing early cases needs to be balanced against appropriate levels of referral and excision of benign lesions. Read More

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December 2018
4 Reads

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

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December 2018
3 Reads

Inhaled steroids with and without regular salmeterol for asthma: serious adverse events.

Cochrane Database Syst Rev 2018 Dec 3;12:CD006922. Epub 2018 Dec 3.

Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

Background: Epidemiological evidence has suggested a link between use of beta₂-agonists and increased asthma mortality. Much debate has surrounded possible causal links for this association, and whether regular (daily) long-acting beta₂-agonists (LABAs) are safe, particularly when used in combination with inhaled corticosteroids (ICSs). This is an update of a Cochrane Review that now includes data from two large trials including 11,679 adults and 6208 children; both were mandated by the US Food and Drug Administration (FDA). Read More

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December 2018
5 Reads

Quantification of image artifacts from navigation markers in dynamic guided implant surgery and the effect on registration performance in different clinical scenarios.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Different navigation markers in dynamic guided implant surgery could cause different degrees of artifacts, which would affect the accuracy and efficiency of the implant navigation system. This study aimed to quantify artifacts caused by navigation markers made of different materials and to evaluate their effects on registration accuracy under various oral conditions.

Materials And Methods: Four U-shaped tubes with different navigation markers (440c stainless steel, silicon nitride, zirconium oxide, and aluminium oxide) were produced by three-dimensional printing. Read More

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December 2018
1 Read

The promises and risks of probiotic Bacillus species.

Acta Biochim Pol 2018 Dec 6. Epub 2018 Dec 6.

Uniwersytet Gdański Wydział Chemii Katedra Biotechnologii Molekularnej ul. Wita Stwosza 63 80-308 Gdańsk.

Supplementing the human microbiome with probiotic microorganisms is a proposed solution for civilization syndromes such as dysbiosis and gastrointestinal tract (GIT) disorders. Bimodal probiotic strains of the Bacillus genus constitute the microbiota of the human environment, and are typically found in soil, water, a number of non-dairy fermented foods, as well as in human and animal GIT. Probiotic Bacillus sp. Read More

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December 2018

Patient-reported outcomes associated with different restorative techniques in pediatric dentistry: A systematic review and MTC meta-analysis.

PLoS One 2018 6;13(12):e0208437. Epub 2018 Dec 6.

Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.

Background: Despite the increasing number of studies evaluating patient reported outcome measures (PROs), there is no clearness regarding which restorative treatment offers major benefits based on the pediatric patient perspective.

Aim: To compare different restorative techniques in pediatric dentistry regarding patient-reported outcomes.

Design: Literature searching was carried out on prospective studies indexed in PubMed, Scopus and OpenGrey. Read More

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December 2018
1 Read

A gradient-based, GPU-accelerated, high-precision contour-segmentation algorithm with application to cell membrane fluctuation spectroscopy.

PLoS One 2018 6;13(12):e0207376. Epub 2018 Dec 6.

Mechanics of Biological Membranes and Biorheology, Dpto. Química Física I, Universidad Complutense, Madrid, Spain.

We present a novel intensity-gradient based algorithm specifically designed for nanometer-segmentation of cell membrane contours obtained with high-resolution optical microscopy combined with high-velocity digital imaging. The algorithm relies on the image oversampling performance and computational power of graphical processing units (GPUs). Both, synthetic and experimental data are used to quantify the sub-pixel precision of the algorithm, whose analytic performance results comparatively higher than in previous methods. Read More

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December 2018

Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.

PLoS One 2018 6;13(12):e0208127. Epub 2018 Dec 6.

Queen Margaret University, Centre of Health, Activity and Rehabilitation Research, Edinburgh, United Kingdom.

Background: Stage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients. Read More

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December 2018

Effect of positive carbon-11-choline PET/CT results in the therapeutic management of prostate cancer biochemical relapse.

Nucl Med Commun 2019 Jan;40(1):79-85

Department of Nuclear Medicine, Marqués de Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.

Objective: Carbon-11-(C)-choline PET/computed tomography (CT) has shown good results in re-staging of prostate cancer (PCa) with raised serum levels of prostate-specific antigen. Our aim was to evaluate the effect of positive C-choline PET/CT results in the therapeutic management of patients with PCa with biochemical relapse (BR) after curative intention treatment.

Patients And Methods: A total of 112 patients with PCa BR and positive C-choline PET/CT were retrospectively evaluated. Read More

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January 2019

The appropriate whole body metric for calculating standardised uptake value and the influence of sex.

Nucl Med Commun 2019 Jan;40(1):3-7

Brighton and Sussex Medical School, Brighton.

Aim: To compare weight, lean body mass and body surface area for calculation of standardised uptake value (SUV) in fluorine-18-fluorodeoxyglucose PET/computed tomography, taking sex into account.

Patients And Methods: This was a retrospective study of 161 (97 men) patients. Maximum standardised uptake value (SUVmax) and mean standardised uptake value (SUVmean) were obtained from a 3-cm region of interest over the right lobe of the liver and scaled to weight, scaled to lean body mass (SUL) and scaled to body surface area (SUA). Read More

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January 2019

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients.

Rom J Intern Med 2018 Dec;56(4):257-264

Kharkiv National Medic University, Nauky Ave., Kharkiv, Ukraine.

Introduction: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. Read More

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December 2018
1 Read

Improved on-the-fly MCTDH simulations with many-body-potential tensor decomposition and projection diabatisation.

J Chem Theory Comput 2018 Dec 6. Epub 2018 Dec 6.

We have recently demonstrated how potential energy surface (PES) interpolation methods such as kernel ridge regression (KRR), can be combined with accurate wavefunction time-propagation methods, specifically the multi-configuration time-dependent Hartree (MCTDH) method, to generate a new "on-the-fly" MCTDH scheme (DD-MCTDH) which does not require the pre-fitting of the PES which is normally required by MCTDH. Specifically, we have shown how our DD-MCTDH strategy can be used to model non-adiabatic dynamics in a 4-mode/2-state model of pyrazine, with ab initio electronic structure calculations performed directly during propagation, requiring around 100 hours of computer wall-time. In this Article, we show how the efficiency and accuracy of DD-MCTDH can be dramatically improved further still by: (i) using systematic tensor decompositions of the KRR PES, and (ii) using a novel scheme for diabatisation within the framework of configuration interaction (CI) methods which only requires local adiabatic electronic states, rather than non-adiabatic coupling matrix elements. Read More

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December 2018

Interconnection of sulfides and sulfoxides in medicinal chemistry.

Arch Pharm (Weinheim) 2018 Dec 6:e1800248. Epub 2018 Dec 6.

Institute of Pharmacy, University of Greifswald, Greifswald, Germany.

Aromatic heterocycles with basic nitrogen atoms as well as carboxylic acid derivatives are the dominating chemical space in the universe of drug-like molecules. These established and exceedingly evaluated structural motifs have to be combined with elements of diversity in order to chart less well-explored galaxies of chemical space and to be able to tackle seemingly undruggable targets. Flat scaffolds should be replaced by shapely molecular cores. Read More

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December 2018
1 Read

The association between markers of tumor cell metabolism, the tumor microenvironment and outcomes in patients with colorectal cancer.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Unit of Experimental Therapeutics, Institute of Cancer Science, University of Glasgow, Glasgow, UK.

Tumor cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumor microenvironment, and outcome in patients with colorectal cancer. A cohort of 150 patients with stage I-III CRC were utilised to assess tumor cell expression of MCT-1, MCT-2, LDH-1 and LDH5 by immunohistochemistry. Read More

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December 2018

Full-arch implant supported rehabilitations: A prospective study comparing porcelain-veneered zirconia frameworks to monolithic zirconia.

Clin Oral Implants Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Oral Surgery and Implant Dentistry, Faculdade de Medicina Dentária da Universidade de Lisboa, Portugal.

Objectives: To evaluate the performance of two types of zirconia frameworks.

Material And Methods: From 2014 to 2016, in a prospective clinical trial 150 patients were rehabilitated with 83 and 110 implant-supported, screw-retained, full-arch ceramic-veneered zirconia (PVZ) rehabilitations and monolithic zirconia with porcelain veneering limited to buccal (MZ) rehabilitations, respectively. Patients were consecutively enlisted according to pre-defined inclusion criteria and evaluated on 4 months intervals. Read More

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December 2018

Photofunctionalizing effects of hydroxyapatite combined with TiO on bone regeneration in rabbit calvarial defects.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.

The hydrophilicity of bone graft material generally used as a carrier can play an important role in regulating bone morphogenetic protein (BMP) expression at the bone graft site. The hydrophilicity, altering physicochemical properties, and enhancing biological capabilities, can be increased via surface modification through ultraviolet (UV) photofunctionalization and the effect on de novo osteogenesis could be further improved. Therefore, this study aimed to assess the effects of UV-irradiated TiO -coated hydroxyapatite (HA) in combination with rhBMP-2 on bone regeneration in rabbit calvarial defects. Read More

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December 2018

Tolerance and efficacy of BRAF plus MEK inhibition in patients with melanoma who previously have received programmed cell death protein 1-based therapy.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Combined BRAF and MEK inhibition (BRAF-MEK) is a standard therapy for patients with BRAF V600-mutant melanoma, but to the authors' knowledge, the tolerance, adverse event (AE) profile, and efficacy have not been well defined in the post-programmed cell death protein 1 (PD-1) setting.

Methods: Patients with BRAF V600-mutant melanoma who received combined BRAF-MEK after prior PD-1-based therapy were assembled from 4 tertiary care centers in the United States and Australia. Dose modification was defined as a treatment break, dose reduction, or intermittent dosing. Read More

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December 2018

Docosahexaenoic acid promotes cell cycle arrest and decreases proliferation through WNT/β-catenin modulation in colorectal cancer cells exposed to γ-radiation.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil.

The effects of radiation are known to be potentiated by N-3 polyunsaturated fatty acids, which modulate several signaling pathways, but the molecular mechanisms through which these fatty acids enhance the anticancer effects of irradiation in colorectal cancer (CRC) treatment remain poorly elucidated. Here, we aimed to ascertain whether the fatty acid docosahexaenoic acid (DHA) exerts a modulating effect on the response elicited by radiation treatment (RT). Two CRC cell lines, Caco-2 and HT-29, were exposed to RT, DHA, or both (DHA + RT) for various times, and then cell viability, proliferation, and clonogenicity were assessed. Read More

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December 2018

Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth.

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Department of Endocrinology, Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Copenhagen Denmark.

Context And Objective: Being born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown. We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.

Design, Participants And Methods: This study is a longitudinal birth cohort study. Read More

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December 2018

Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia.

J Trop Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning city, 530021 China.

Aim: The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia.

Methods: A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group. Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. Read More

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December 2018

Annotation of the Giardia proteome through structure-based homology and machine learning.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia.

Background: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical structure determination with particular promise for non-model organisms and neglected pathogens. Conventional sequence-based tools are insufficient to annotate the genomes of such divergent biological systems. Conversely, protein structure tolerates substantial variation in primary amino acid sequence, and is thus a robust indicator of biochemical function. Read More

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December 2018
2 Reads

Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.

J Natl Cancer Inst 2018 Dec 6. Epub 2018 Dec 6.

Nanchang Center for Disease Control and Prevention, Nanchang, China.

Background: There is international consensus that benzene exposure is causally related to acute myeloid leukemia (AML), and more recent evidence of association with myelodysplastic syndromes (MDS). However, there are uncertainties about the exposure response, particularly risks by time since exposure and age at exposure.

Methods: In a case-cohort study in 110 631 Chinese workers followed up during 1972-1999 we evaluated combined MDS/AML (n = 44) and chronic myeloid leukemia (n = 18). Read More

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December 2018
3 Reads

Protein-protein interaction sites prediction by ensemble random forests with synthetic minority oversampling technique.

Bioinformatics 2018 Dec 5. Epub 2018 Dec 5.

Bioinformatics and Mathematical Biosciences Lab, Department of Agronomy, Horticulture and Plant Science, South Dakota State University, Brookings, SD, USA.

Motivation: The prediction of protein-protein interaction (PPI) sites is a key to mutation design, catalytic reaction, and the reconstruction of PPI networks. It is a challenging task considering the significant abundant sequences and the imbalance issue in samples.

Results: A new ensemble learning based method, EL-SMURF, was proposed for PPI sites prediction in this study. Read More

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December 2018
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Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern may be Characterized by ARID1A Genetic Alterations.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa.

Cholangiolocellular carcinoma (CLC) is a unique subtype of primary liver carcinoma, which sometimes coexists with hepatocellular carcinoma (HCC), cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). "Ductal plate malformation" (DPM)-pattern of primary liver carcinoma, which resembles biliary lesions in Caroli disease and von Meyenburg complex, is sometimes associated with CLC. We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC. Read More

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December 2018
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Laparoscopic Multiple Parenchyma-sparing Concomitant Liver Resections for Colorectal Liver Metastases.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Intervention Centre.

Background: Parenchyma-sparing concept in liver surgery has received a new incitement with the introduction of laparoscopic techniques. Multiple concomitant liver resections are a major component in the parenchyma-sparing concept.

Materials And Methods: In total, 689 patients underwent laparoscopic liver resection for colorectal liver metastases from August 1998 to 2017, and 171 patients were eligible for this study. Read More

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December 2018

The Impact of Individual Mentored Career Development (K) Awards on the Research Trajectories of Early-Career Scientists.

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

S. Nikaj is a labor economist, Division of Biomedical Research Workforce, Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, Maryland. P.K. Lund is director, Division of Biomedical Research Workforce, Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, Maryland.

Purpose: This analysis examined the role of a National Institutes of Health (NIH) individual Mentored Career Development Award (K01, K08, K23) on launching and sustaining independent research careers for early-career scientists and investigated the effects of these awards during and after the doubling of the NIH budget.

Method: The authors used grants data from the NIH covering the period 1990 through 2016 and compared success in receipt of R01 equivalent awards (R01 Eq.) and Research Project Grants (RPGs) for K awardees and K applicants who did not receive funding. Read More

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December 2018

Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation.

Cardiol Rev 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.

Atrial fibrillation (AF) is associated with a substantially higher risk of thromboembolism, particularly stroke events, resulting in significant morbidity and mortality. Oral anticoagulation (OAC), while effective in reducing embolic events in AF patients, is associated with an increased bleeding risk. Thus, not all patients with AF are candidates for OAC and some are only candidates for OAC in the short term. Read More

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December 2018
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Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice.

Radiat Res 2018 Dec 6. Epub 2018 Dec 6.

a   Columbia University Medical Center, New York, New York.

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. Read More

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December 2018
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Exploring the Brain Lateralization in ADHD Based on Variability of Resting-State fMRI Signal.

J Atten Disord 2018 Dec 6:1087054718816170. Epub 2018 Dec 6.

1 Nanjing University of Science & Technology, China.

Objective: In this study, we investigate the brain lateralization in ADHD patients. Furthermore, we also explore the difference between male and female patients, and the difference among distinct ADHD subtypes, that is, ADHD-inattentive (ADHD-IA) and ADHD-combined (ADHD-C).

Method: We employed the standard deviation to quantify the variability of resting-state functional magnetic resonance imaging (fMRI) signal and measure the lateralization index (LI). Read More

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December 2018
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Psychological benefits of attending the theatre associated with positive affect and well-being for subscribers over age 60.

Aging Ment Health 2018 Dec 6:1-8. Epub 2018 Dec 6.

a Dept. of Psychological & Brain Sciences , University of Louisville , Louisville , KY , USA.

Objectives: Although late adulthood may be a time of greater well-being, optimal aging still characterizes a minority of older adults. Understanding how individuals achieve well-being across adulthood is important for intervention and social policy. We focused on how attending live theatre might enhance the well-being of a sample of 53 season ticket holders aged 60 and older. Read More

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December 2018
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