887,000 results match your criteria Combination Products in Therapy [Journal]


PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

Fisetin and 5-Fluorouracil: Effective Combination for PIK3CA-Mutant Colorectal Cancer.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

The normal colon epithelium is transformed into its neoplastic counterpart through a series of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment often involves surgery followed by 5-fluorouracil (5-FU) based therapy, which has limited efficiency and serious side effects. We sought to determine whether fisetin, a dietary flavonoid, alone or in combination with 5-FU affected tumorigenesis in the mammalian intestine. Read More

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http://dx.doi.org/10.1002/ijc.32367DOI Listing

Parameterizing and validating existing algorithms for identifying out-of-bed time using hip-worn accelerometer data from older women.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, UNITED STATES.

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. 
 
 Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). Read More

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http://iopscience.iop.org/article/10.1088/1361-6579/ab1c04
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http://dx.doi.org/10.1088/1361-6579/ab1c04DOI Listing
April 2019
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Objective assessment of blinking and facial expressions in Parkinson's disease using vertical electrooculogram and facial surface electromyography.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Istituto di BioRobotica, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, Pontedera, 56025, ITALY.

Objective: Hypomimia is a common and early symptom of Parkinson's disease (PD), which reduces the ability of PD patients in manifesting emotions. Currently, it is visually evaluated by the neurologist during neurological examinations for PD diagnosis as described in task 3.2 of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Read More

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http://dx.doi.org/10.1088/1361-6579/ab1c05DOI Listing

Pulp improvement of oil palm empty fruit bunches associated to solid-state biopulping and biobleaching with xylanase and lignin peroxidase cocktail produced by Aspergillus sp. LPB-5.

Bioresour Technol 2019 Apr 18;285:121361. Epub 2019 Apr 18.

Department of Agricultural Sciences and Technology, Federal University of Tocantins, CEP 7740-2970, Gurupi, TO, Brazil; Department of Bioprocess and Biotechnology Engineering, Federal University of Paraná, CEP 81531-970, Curitiba, PR, Brazil. Electronic address:

Oil palm empty fruit bunches is a lignocellulosic feedstock with biotechnological potential and thousands of tons are generated in the world each year. Filamentous fungi producing xylanases and ligninases in biopulping to obtain cellulose is a pulp improvement alternative. The enzymatic cocktail was produced in solid-state biopulping by Aspergillus sp. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121361DOI Listing

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D.

Cell Rep 2019 Apr;27(4):1151-1164.e5

Department of Biology, Tufts University, Suite 4700, 200 Boston Ave., Medford, MA 02155, USA; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA. Electronic address:

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cells. Flex1 fragility is dependent on the ability of a variable-length AT repeat to form a cruciform structure that stalls replication. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.103DOI Listing

Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
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Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

Expert Rev Mol Diagn 2019 Apr 24. Epub 2019 Apr 24.

b Aix Marseille University , CRCM, INSERM, CNRS, AP-HM, Multidisciplinary Oncology and Therapeutic Innovations Department , Chemin des Bourrely, 13015 , Marseille , France .

Introduction: Companion diagnostic tests (CDXs) are considered mandatory for decision making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1 immunohistochemistry tests, have been questioned and re-examined for use with new combination therapies that are being evaluated in clinical trials. Read More

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http://dx.doi.org/10.1080/14737159.2019.1611426DOI Listing

Enhancement of the Monolayer Tungsten-Disulfide Exciton Photoluminescence with a Two-Dimensional-Material/Air/Gallium-Phosphide In-Plane Microcavity.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Light-matter interaction with two-dimensional materials gained significant attention in recent years leading to the reporting of weak and strong coupling regimes, and effective nano-laser operation with various structures. Particularly, future applications involving monolayer materials in waveguide-coupled on-chip integrated circuitry and valleytronic nanophotonics require controlling, directing and optimizing photoluminescence. In this context, photoluminescence enhancement from monolayer transition-metal dichalcogenides on patterned semiconducting substrates becomes attractive. Read More

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http://dx.doi.org/10.1021/acsnano.8b09659DOI Listing

Enhancement of Photocatalytic Activity of Bi O -BiOI Composite Nanosheets through Vacancy Engineering.

Small 2019 Apr 24:e1900020. Epub 2019 Apr 24.

Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.

Vacancy engineering is an effective strategy to enhance solar-driven photocatalytic performance of semiconductors. It is highly desirable to improve the photocatalytic performance of composite nanomaterials by the introduction of vacancies, but the role of vacancies and the heterostructure in the photocatalytic process is elusive to the composite nanomaterials. Herein, the introduction of I vacancies can significantly enhance the photocatalytic activity of Bi O -BiOI composite nanosheets in a synergistic manner. Read More

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http://dx.doi.org/10.1002/smll.201900020DOI Listing

Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma.

Small 2019 Apr 24:e1900157. Epub 2019 Apr 24.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.

Tumor metastasis is considered a major cause of cancer-related human mortalities. However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent nanoplatform for the highly effective treatment of the metastatic melanoma is reported. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019001
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http://dx.doi.org/10.1002/smll.201900157DOI Listing
April 2019
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Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.

Adv Mater 2019 Apr 24:e1805798. Epub 2019 Apr 24.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute for Advanced Materials, and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.

Self-assembly is a powerful tool for constructing supramolecular materials for many applications, ranging from energy harvesting to biomedicine. Among the methods to prepare supramolecular materials for biomedical applications, enzyme-instructed self-assembly (EISA) has several advantages. Herein, the unique properties and advantages of EISA in preparing biofunctional supramolecular nanomaterials and hydrogels from peptides are highlighted. Read More

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http://dx.doi.org/10.1002/adma.201805798DOI Listing

Surface-Dependent Chemoselectivity in C-C Coupling Reactions.

Angew Chem Int Ed Engl 2019 Apr 24. Epub 2019 Apr 24.

INT-KIT-CN, Institute of Nanoatechnology, Helmholtz-Platz1, 76344, Linkenheim-Eggenstein, GERMANY.

Surface-confined covalent coupling reactions of the linear compound 4-(but-3-en-1-ynyl)-4'-ethynyl-1,1'-biphenyl (1), containing one alkyne and one enyne group in head and tail positions respectively, have been investigated by using scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. Distinct on-surface C-C coupling reactions exhibiting surface-dependent chemoselectivity were identified. On Au(111), compound 1 yields preferentially cyclotrimerization products, while on Cu(111) the selective coupling between the enyne and alkyne group. Read More

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http://dx.doi.org/10.1002/anie.201900636DOI Listing

The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression.

PLoS One 2019 24;14(4):e0215601. Epub 2019 Apr 24.

Department of Medicine, University of Washington, Seattle, WA, United States of America.

During periods in which glucose absorption from the gastrointestinal (GI) tract is insufficient to meet body requirements, hepatic gluconeogenesis plays a key role to maintain normal blood glucose levels. The current studies investigated the role in this process played by vasodilatory-associated phosphoprotein (VASP), a protein that is phosphorylated in hepatocytes by cAMP/protein kinase A (PKA), a key mediator of the action of glucagon. We report that following stimulation of hepatocytes with 8Br-cAMP, phosphorylation of VASP preceded induction of genes encoding key gluconeogenic enzymes, glucose-6-phosphatase (G6p) and phosphoenolpyruvate carboxykinase (Pck1), and that VASP overexpression enhanced this gene induction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215601PLOS
April 2019
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How conspicuous are peacock eyespots and other colorful feathers in the eyes of mammalian predators?

PLoS One 2019 24;14(4):e0210924. Epub 2019 Apr 24.

Migratory Bird Center, Smithsonian Conservation Biology Institute, National Zoological Park, Washington DC, United States of America.

Colorful feathers have long been assumed to be conspicuous to predators, and hence likely to incur costs due to enhanced predation risk. However, many mammals that prey on birds have dichromatic visual systems with only two types of color-sensitive visual receptors, rather than the three and four photoreceptors characteristic of humans and most birds, respectively. Here, we use a combination of multispectral imaging, reflectance spectroscopy, color vision modelling and visual texture analysis to compare the visual signals available to conspecifics and to mammalian predators from multicolored feathers from the Indian peacock (Pavo cristatus), as well as red and yellow parrot feathers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210924PLOS
April 2019
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Host immune responses induced by specific Mycobacterium leprae antigens in an overnight whole-blood assay correlate with the diagnosis of paucibacillary leprosy patients in China.

PLoS Negl Trop Dis 2019 Apr 24;13(4):e0007318. Epub 2019 Apr 24.

Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Leprosy, caused by Mycobacterium leprae, affects over 200,000 people annually worldwide and remains endemic in the ethnically diverse, mountainous and underdeveloped southwestern provinces of China. Delayed diagnosis of leprosy persists in China, thus, additional knowledge to support early diagnosis, especially early diagnosis of paucibacillary (PB) patients, based on the host immune responses induced by specific M. leprae antigens is needed. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007318DOI Listing

An elucidation of over a century old enigma in genetics-Heterosis.

PLoS Biol 2019 Apr 24;17(4):e3000215. Epub 2019 Apr 24.

Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, United States of America.

Recognition and exploitation of hybrid vigor or heterosis among individual crosses of plants and animals has a long and distinguished history. Its manifestation is influenced by a combination of genetic, epigenetic, phenotypic, and environmental factors. Although heterosis is known to be governed by both dominant and epistatic gene action, its expression is greatly influenced by nonlinear interaction among epigenetic and phenotypic (phenomic) components. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000215DOI Listing

Diagnostic Accuracy of the Sampling Utterances and Grammatical Analysis Revised (SUGAR) Measures for Identifying Children With Language Impairment.

Lang Speech Hear Serv Sch 2019 Apr;50(2):211-223

Department of Communication Sciences & Disorders, The College of Saint Rose, Albany, NY.

Purpose The purpose of this study was twofold: (a) to determine the diagnostic accuracy of the four Sampling Utterances and Grammatical Analysis Revised (SUGAR) metrics, including total number of words, mean length of utterance, words per sentence, and clauses per sentence in differentiating children with language impairment (LI) from those with typical language development, and (b) to compare the average time to collect, transcribe, and analyze 50-utterance language samples for children with LI to those with typical language development. Method Participants were 306 children (LI, 36; typical language development, 270) who ranged in age from 3;0 (years;months) to 7;11. Fifty-utterance conversational language samples were obtained using a conversational protocol. Read More

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http://dx.doi.org/10.1044/2018_LSHSS-18-0050DOI Listing

A Combined Experimental and Computational Study on the Reaction Dynamics of the 1-Propynyl (CHCC) - 1,3-Butadiene (CHCHCHCH) System and the Formation of Toluene Under Single Collision Conditions.

J Phys Chem A 2019 Apr 24. Epub 2019 Apr 24.

The crossed beams reactions of the 1-propynyl radical (CHCC; XA) with 1,3-butadiene (CHCHCHCH; XA), 1,3-butadiene-d (CDCDCDCD; XA), 1,3-butadiene-d (CDCHCHCD; XA), and 1,3-butadiene-d (CHCDCDCH; XA) were performed under single collision conditions at collision energies of about 40 kJ mol. The underlying reaction mechanisms were unraveled through the combination of the experimental data with electronic structure calculations at the CCSD(T)-F12/cc-pVTZ-f12//B3LYP/6-311G(d,p) + ZPE(B3LYP/6-311G(d,p) level of theory along with statistical Rice-Ramsperger-Kassel-Marcus (RRKM) calculations.Together, these data suggest the formation of at least toluene (CH) via the barrierless addition of 1-propynyl to the 1,3-butadiene terminal carbon atom forming a low-lying CH intermediate that undergoes multiple isomerization steps resulting in cyclization and ultimately aromatization following hydrogen atom elimination. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b00092DOI Listing

Halogenated Tyrosine Derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini.

J Nat Prod 2019 Apr 24. Epub 2019 Apr 24.

Marine Biodiscovery, School of Chemistry and Ryan Institute , National University of Ireland Galway (NUI Galway) , University Road , H91 TK33 Galway , Ireland.

In the search for bioactive marine natural products from zoantharians of the Tropical Eastern Pacific, four new tyrosine dipeptides, named valdiviamides A-D (1-4), were isolated from Antipathozoanthus hickmani, and two new tyramine derivatives, 5 and 6, from Parazoanthus darwini. The phenols of all six tyrosine derivatives are substituted by bromine and/or iodine atoms at the ortho positions of the hydroxyl. The planar structures of these aromatic alkaloids were elucidated from 1D and 2D NMR experiments in combination with HRESIMS data, and the absolute configurations of 1-4 were deduced from comparison between experimental and calculated electronic circular dichroism spectra. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.9b00173DOI Listing

Atomistic modeling of the ABL kinase regulation by allosteric modulators using structural perturbation analysis and community-based network reconstruction of allosteric communications.

J Chem Theory Comput 2019 Apr 24. Epub 2019 Apr 24.

In this work, we have examined the molecular mechanisms of allosteric regulation of the ABL tyrosine kinase at the atomic level. Atomistic modeling of the ABL complexes with a panel of allosteric modulators has been performed using a combination of molecular dynamics simulations, structural residue perturbation scanning and a novel community analysis of the residue interaction networks. Our results have indicated that allosteric inhibitors and activators may exert a differential control on allosteric signaling between the kinase binding sites and functional regions. Read More

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http://dx.doi.org/10.1021/acs.jctc.9b00119DOI Listing

Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin.

J Nat Prod 2019 Apr 24. Epub 2019 Apr 24.

Centre for Cellular and Molecular Biology , Hyderabad 500007 , India.

Two new resin glycosides, ipomeolides A (1) and B (2), both with an unusual nonlinear heteropentasaccharide core, along with five known compounds were isolated from the n-hexane/CHCl (1:1) extract of the aerial parts of Ipomoea pes-caprae. Ipomeolides A (1) and B (2) are macrolactone analogues of the rare (11 R)-jalapinolic acid, and macrolactonization occurred at C-2 of the second saccharide moiety. Compounds 1 and 2 show structural variation even in the pentasaccharide core. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01100DOI Listing

Temperature-controlled orientation of proteins on temperature-responsive grafted polymer brushes. Poly(butyl methacrylate) versus poly(butyl acrylate): Morphology, wetting and protein adsorption.

Biomacromolecules 2019 Apr 24. Epub 2019 Apr 24.

The poly(n-butyl methacrylate) - (PBMA) or poly(n-butyl acrylate) - (PBA) grafted brush coatings attached to glass were successfully prepared using ATR polymerization "from the surface." The thicknesses and composition of the PBMA and PBA coatings were examined using ellipsometry and ToF-SIMS, respectively. For PBMA the glass transition temperature constitutes a range close to the physiological, this being in contrast to PBA where the glass transition temperature is around -55˚C. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00030
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http://dx.doi.org/10.1021/acs.biomac.9b00030DOI Listing
April 2019
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From Molecular and Emulsified Ion Sensors to Membrane Electrodes: Molecular and Mechanistic Sensor Design.

Acc Chem Res 2019 Apr 24. Epub 2019 Apr 24.

University of Geneva , Department of Inorganic and Analytical Chemistry , Quai Ernest Ansermet 30 , Geneva 1211 , Switzerland.

Selective molecular ion probes are often insoluble in water and require a hydrophobic solvent environment for strong and selective binding, which runs counter to the desire of utilizing them in a homogeneous solution. This Account aims to guide the reader on how such molecules, often coined ionophores, can be harnessed to design exceptionally useful optical and electrochemical sensors. We start here with some historical context on the design of such ionophores and continue with the explanation of the response mechanism of optical and potentiometric sensors and the role of combined components to build a robust ion sensor. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00056DOI Listing
April 2019
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Laser Treatment of Skin of Color for Medical and Aesthetic Uses With a New 650-Microsecond Nd:YAG 1064nm Laser

J Drugs Dermatol 2019 Apr;18(4):s135-137

Individuals with skin of color are a rapidly growing portion of the cosmetic procedures market. There are unique challenges to treating skin conditions in skin of color patients. This article and roundtable discussion focus on the use of energy-based modalities, particularly a 650-microsecond 1064nm laser that delivers energy in a collimated beam. Read More

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Open-label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy.

J Cosmet Dermatol 2019 Apr 24. Epub 2019 Apr 24.

The Pearl Dermatology, Houston, Texas.

Background: Intense pulsed light therapy (IPL) decreases facial erythema and telangiectasias associated with rosacea. Topical skin care products decrease facial erythema by the action of active ingredients and masking effects.

Objectives: To assess the efficacy and tolerability of combining a topical skin care regimen (TSCR) comprised of a multifunctional three-in-one facial cream and a mineral-based brush-on SPF50 powder sunscreen with a single IPL treatment for treating mild-to-severe facial redness associated with rosacea. Read More

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http://dx.doi.org/10.1111/jocd.12952DOI Listing

The Glycosylation Mechanisms of 6,3-Uronic Acid Lactones.

Angew Chem Int Ed Engl 2019 Apr 24. Epub 2019 Apr 24.

Radboud University, Molecular Chemistry, Heyendaalseweg 135, 6525AJ, Nijmegen, NETHERLANDS.

Uronic acids are important constituents of polysaccharides found on the cell membranes of different organisms. To prepare uronic acid containing oligosaccharides, uronic acid 6,3-lactones can be employed as they display a fixed conformation and a unique reactivity and stereoselectivity. Herein we report a highly β-selective and efficient mannosyl donor based on C-4 acetyl mannuronic acid 6,3-lactone donors. Read More

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http://dx.doi.org/10.1002/anie.201902507DOI Listing

Tabletop Extreme Ultraviolet Time-Of-Flight Spectrometry for Trace Analysis of High Ionization Energy Samples.

Rapid Commun Mass Spectrom 2019 Apr 24. Epub 2019 Apr 24.

Swiss Federal Laboratories for Materials Science and Technology (Empa), Überlandstrasse 129, CH-8600, Dübendorf, Switzerland.

Rationale: Species with ionization energies beyond what is accessible using state-of-the-art lab sources, are affected by poor detection limits in ordinary mass spectrometry setups, whose throughput is also often limited. XUV photoionization mass spectrometry, in combination with linear time-of-flight (TOF), is necessary for the sensitive detection of high ionization energy compounds at trace level. XUV photoionization is available at beamlines, although with limited access. Read More

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http://dx.doi.org/10.1002/rcm.8463DOI Listing

WITHDRAWN: Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults.

Cochrane Database Syst Rev 2019 Apr 24;4:CD009857. Epub 2019 Apr 24.

Cochrane Croatia, School of Medicine, University of Split, Soltanska 2, Split, Splitsko-dalmatinska County, Croatia, 21 000.

Background: Effective oral hygiene is a crucial factor in maintaining good oral health, which is associated with overall health and health-related quality of life. Dental floss has been used for many years in conjunction with toothbrushing for removing dental plaque in between teeth, however, interdental brushes have been developed which many people find easier to use than floss, providing there is sufficient space between the teeth.

Objectives: To evaluate the effects of interdental brushing in addition to toothbrushing, as compared with toothbrushing alone or toothbrushing and flossing for the prevention and control of periodontal diseases, dental plaque and dental caries. Read More

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http://dx.doi.org/10.1002/14651858.CD009857.pub3DOI Listing

Personalized Design of Functional Gradient Bone Tissue Engineering Scaffold.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing 210016, Jiangsu Province, People's Republic of China.

The porous structure of the natural bone not only has the characteristics of lightweight and high strength, but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Read More

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http://dx.doi.org/10.1115/1.4043559DOI Listing

Z-scheme photocatalyst systems employing Rh- and Ir-doped metal oxide materials for water splitting under visible light irradiation.

Faraday Discuss 2019 Apr 24. Epub 2019 Apr 24.

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. and Photocatalysis International Research Center, Research Institute for Science and Technology, Tokyo University of Science, 2641, Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan.

Various types of Z-scheme systems for water splitting under visible light irradiation were successfully developed by employing Rh- and Ir-doped metal oxide powdered materials with relatively narrow energy gaps (EG): BaTa2O6:Ir,La (EG: 1.9-2.0 eV), NaTaO3:Ir,La (EG: 2. Read More

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http://dx.doi.org/10.1039/c8fd00209fDOI Listing

Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).

Int J Vitam Nutr Res 2019 Apr 24:1-10. Epub 2019 Apr 24.

6 Associate professor of Radiology, Faculty of paramedical, Tabriz University of Medical Sciences, Tabriz, Iran.

In an attempt to investigate new strategies aimed at reducing risk factors of non-alcoholic fatty liver disease (NAFLD), effects of turmeric (Curcuma longa L.) and chicory seed (Cichorium intybus L.) supplementation was evaluated in these patients. Read More

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http://dx.doi.org/10.1024/0300-9831/a000568DOI Listing

The Most Beautiful Man: An Integration of Hypnosis and Biofeedback for Depression and Dissociation.

Authors:
Donald Moss

Am J Clin Hypn 2019 Apr;61(4):322-334

a Saybrook University , Oakland , CA.

Hypnosis and biofeedback techniques are evidence-based psychophysiological therapies that can be applied with a wide variety of medical and mental health disorders. Research shows efficacy for anxiety, depression, post-traumatic stress disorder (PTDS), chronic pain, hypertension, fibromyalgia, and a host of other disorders. Hypnosis and biofeedback can also augment the effectiveness of psychotherapy. Read More

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http://dx.doi.org/10.1080/00029157.2018.1517082DOI Listing

Combination of pulsed dye laser and verapamil in comparison with verapamil alone in the treatment of keloid.

J Dermatolog Treat 2019 Apr 24:1-22. Epub 2019 Apr 24.

a Department of Dermatology, Venereology and Andrology, Faculty of Medicine , Zagazig University , Egypt.

Background And Objective: Keloids are abnormal fibrous reactions that persist for prolonged periods. Many modalities of treatment have been advocated but the success rates of these have been variable. The present study is an attempt to evaluate and compare the efficacy of a combination of pulsed dye laser (PDL) and intralesional verapamil against intralesional verapamil alone in the treatment of keloids Methods: 40 Patients with keloids were divided into two groups randomly of 20 each receiving four sessions of therapy. Read More

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http://dx.doi.org/10.1080/09546634.2019.1610550DOI Listing

Does choice of antiretroviral drugs matter for inflammation?

Expert Rev Clin Pharmacol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a HIV Infection Unit, Infectious Diseases Department , Hospital de la Santa Creu i Sant Pau Institut de Recerca del Hospital de la Santa Creu i Sant Pau , Barcelona , Spain.

Introduction: The massive implementation of combination antiretroviral therapy (cART) has forever changed the landscape of HIV infection. This unprecedented success has turned HIV infection into a manageable chronic disease. The increased survival of people living with HIV is, however, shadowed by a high burden of aging-related comorbidities. Read More

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http://dx.doi.org/10.1080/17512433.2019.1605902DOI Listing

Anti-miRNA21 and resveratrol-loaded polysaccharide-based mesoporous silica nanoparticle for synergistic activity in gastric carcinoma.

J Drug Target 2019 Apr 24:1-31. Epub 2019 Apr 24.

b Department of Endoscopy Center , China-Japan Union Hospital of Jilin University , Changchun , Jilin , China , 130033.

Anti-miR21 and resveratrol (RSV)-loaded mesoporous silica nanoparticles conjugated with hyaluronic acid (HA) were developed to enhance therapeutic efficacy in gastric carcinoma. The surface conjugation of HA, which acts as a targeting ligand to the overexpressed CD44 receptor on gastric cancer cells, was clearly identified by the presence of a greyish shell on the dark mesoporous silica nanoparticles. Confocal laser-scanning microscopy and flow cytometry analysis showed higher cellular internalization of HA/RSVmirNP compared to RSVmirNP. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1610766DOI Listing

Clinical Effectiveness of Traditional and Complementary Medicine Interventions in Combination with Nicotine Replacement Therapy on Smoking Cessation: A Randomized Controlled Pilot Trial.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

4 Department of Preventive Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.

Smoking is associated with many preventable diseases and deaths. Globally, more than 6 million deaths per year are related to smoking. This study aimed to evaluate the pragmatic effectiveness of traditional and complementary medicine (T&CM) interventions for the smoking cessation treatment and to calculate the incremental cost-effectiveness ratio (ICER) of these interventions. Read More

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http://dx.doi.org/10.1089/acm.2019.0009DOI Listing

Successful Treatment of Refractory Plaque-Type Psoriasis and Psoriatic Arthritis With Guselkumab and Adalimumab Combination Therapy: A Case Report

J Drugs Dermatol 2019 Apr;18(4):394-396

Copy: A number of biologics have been approved for use in plaque-type psoriasis. They act by either blocking the action of a specific type of cell or protein in the immune system. Case presentation: Herein, we report a case of a 46-year-old woman with a 12-year history of severe plaque psoriasis and psoriatic arthritis who was treated successfully with guselkumab and adalimumab after failure of prior topical corticosteroids, cyclosporine and narrow-band ultraviolet B (NBUVB) phototherapy. Read More

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Effective delivery of mitomycin-C and meloxicam by double-layer electrospun membranes for the prevention of epidural adhesions.

J Biomed Mater Res B Appl Biomater 2019 Apr 24. Epub 2019 Apr 24.

Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China.

Epidural adhesion between the spinal dura and the surrounding fibrous tissue often occurs post-laminectomy, resulting in clinical symptoms such as nerve compression and severe pain. In this study, we report a drug-loaded double-layered electrospun nanofiber membrane to prevent the occurrence of epidural adhesion. The nanofibers in both layers are made of a mixture of polycaprolactone (PCL) and chitosan (CS) but at different weight ratios. Read More

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http://dx.doi.org/10.1002/jbm.b.34394DOI Listing

The evolution of microendemism in a reef fish (Hypoplectrus maya).

Mol Ecol 2019 Apr 24. Epub 2019 Apr 24.

GEOMAR Helmholtz Centre for Ocean Research Kiel, Marine Evolutionary Ecology, Düsternbrooker Weg 20, 24105, Kiel, Germany.

Marine species tend to have extensive distributions, which are commonly attributed to the dispersal potential provided by planktonic larvae and the rarity of absolute barriers to dispersal in the ocean. Under this paradigm, the occurrence of marine microendemism without geographic isolation in species with planktonic larvae poses a dilemma. The recently described Maya hamlet (Hypoplectrus maya, Serranidae) is exactly such a case, being endemic to a 50-km segment of the Mesoamerican Barrier Reef System (MBRS). Read More

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http://dx.doi.org/10.1111/mec.15110DOI Listing

The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation.

APMIS 2019 Apr 24. Epub 2019 Apr 24.

Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, 2100 Kbh Ø, Copenhagen, Denmark.

Tingstedt JL, Hove-Skovsgaard M, Gaardbo J, Ullum H, Nielsen SD, Gelpi M. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation. Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Read More

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http://dx.doi.org/10.1111/apm.12956DOI Listing

Lycopene restores the effect of ischemic postconditioning on myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.

Int J Mol Med 2019 Jun 15;43(6):2451-2461. Epub 2019 Apr 15.

Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Ischemic postconditioning (IPoC) has been demonstrated to prevent myocardial ischemia‑reperfusion injury (MIRI), but its cardioprotective effect is abrogated by hypercholesterolemia. The aim of the present study was to determine whether lycopene (LP), a type of carotenoid, can restore the cardioprotective effect of IPoC in hypercholesterolemic rats. Male Wistar rats were fed a cholesterol‑enriched diet for 12 weeks to establish a hypercholesterolemic model. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4166DOI Listing

In vivo induction of hepatocellular carcinoma by diethylnitrosoamine and pharmacological intervention in Balb C mice using Bergenia ciliata extracts.

Braz J Biol 2019 Oct-Dec;79(4):629-638. Epub 2019 Jan 14.

Microbial Biotechnology and Medical Toxicology Laboratory, Department of Zoology, University of Azad Jammu and Kashmir, Muzaffarabad-13100, Pakistan.

Background: Hepatocellular carcinoma is the most frequent primary malignancy of liver and accounts for as many as one million deaths worldwide in a year.

Objectives: The aim of the present study was to evaluate the anti-cancerous efficiency of Bergenia ciliata rhizome against diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice.

Methods: One percent diethylnitrosoamine was prepared by using 99 ml of normal saline NaCl (0. Read More

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http://dx.doi.org/10.1590/1519-6984.186565DOI Listing
January 2019

The impact of an isoreticular expansion strategy on the performance of iodine catalysts supported in multivariate zirconium and aluminum metal-organic frameworks.

Dalton Trans 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry and Biochemistry, Texas Tech University, Box 1061, Lubbock, Texas 79409-1061, USA.

Iodine functionalized variants of DUT-5 (Al) and UiO-67 (Zr) were prepared as expanded-pore analogues of MIL-53 (Al) and UiO-67 (Zr). They were prepared using a combination of multivariate and isorecticular expansion strategies. Multivariate MOFs with a 25% iodine-containing linker was chosen to achieve an ideal balance between a high density of catalytic sites and sufficient space for efficient diffusion. Read More

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http://dx.doi.org/10.1039/c9dt00368aDOI Listing

Plastic recovery and self-healing in longitudinally twinned SiGe nanowires.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

This paper reports on plastic recovery and self-healing behavior in longitudinally-twinned and [112] orientated SiGe nanowire (NW) beams when they are subjected to large bending strains. The NW alloys are comprised of lamellar nanotwin platelet(s) sandwiched between two semi-cylindrical twins. The loading curves, which are acquired from atomic force microscope (AFM) based three-point bending tests, reveal the onset of plastic deformation at a characteristic stress threshold, followed by further straining of the NWs. Read More

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http://dx.doi.org/10.1039/c9nr02073jDOI Listing

Acquisition of time-frequency localized mechanical properties of biofilms and single cells with high spatial resolution.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department of Civil and Environmental Engineering, The George Washington University, Washington, DC 20052, USA.

Biofilms are a cluster of bacteria embedded in extracellular polymeric substances (EPS) that contain a complex composition of polysaccharides, proteins, and extracellular DNA (eDNA). Desirable mechanical properties of the biofilms are critical for their survival, propagation, and dispersal, and the response of mechanical properties to different treatment conditions also sheds light on biofilm control and eradication in vivo and on engineering surfaces. However, it is challenging yet important to investigate mechanical behaviors of biofilms with a high spatial resolution because biofilms are very heterogeneous. Read More

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http://dx.doi.org/10.1039/c8nr10287bDOI Listing

Novel Insights into the Management of Oligometastatic Prostate Cancer: A Comprehensive Review.

Eur Urol Oncol 2019 Mar 9;2(2):174-188. Epub 2018 Oct 9.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Urology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Context: The current standard of care for metastatic prostate cancer (PCa) is androgen deprivation therapy (ADT) plus either docetaxel or abiraterone. Growing evidence suggests that metastasis-directed therapy (MDT) and/or local therapy targeted to the primary tumour (ie, prostate) may be of benefit in the setting of oligometastatic disease. Several prospective studies are underway; however, until robust evidence is available to guide treatment decisions, physicians are challenged with how best to manage patients with oligometastases. Read More

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http://dx.doi.org/10.1016/j.euo.2018.09.005DOI Listing

Improved survival after multimodal approach with 131I treatment in patients with bone metastasis secondary to differentiated thyroid cancer.

Thyroid 2019 Apr 24. Epub 2019 Apr 24.

MedStar Health Research Institute, 121577, Medstar Clinical Research Center, Washington, District of Columbia, United States.

Background: The objective of this study was to evaluate the overall survival (OS) of 131I treatments alone and when combined with non-131I treatments in patients with bone metastases (BM) secondary to differentiated thyroid cancer (DTC).

Methods: This was a retrospective study of patients who were evaluated between 2001-2018 at MedStar Washington Hospital Center and had differentiated thyroid cancer (DTC), bone metastases (BM) and at least one 131I treatment after the diagnosis of BM. The OS was analyzed by Kaplan-Meier survival curves and was compared by log-rank test between two groups: patients who received 131I treatments alone and those who received combined 131I treatments with non-131I treatments (CombTx). Read More

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http://dx.doi.org/10.1089/thy.2018.0582DOI Listing

Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care.

J Neurotrauma 2019 Apr 24. Epub 2019 Apr 24.

Uppsala University, Department of neuroscience, neurosurgery, Uppsala, Sweden ;

Traumatic brain injury (TBI) is followed by secondary injury mechanisms strongly involving neuroinflammation. To monitor the complex inflammatory cascade in human TBI, we used cerebral microdialysis (MD) and multiplex proximity extension assay (PEA) technology and simultaneously measured levels of 92 protein biomarkers of inflammation in MD samples every three hours for five days in ten patients with severe TBI under neurointensive care. One µL MD samples were incubated with paired oligonucleotide-conjugated antibodies binding to each protein, allowing quantification by real-time qPCR. Read More

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http://dx.doi.org/10.1089/neu.2018.6320DOI Listing

Improved thermostability of maltooligosyltrehalose synthase from Arthrobacter ramosus by directed evolution and site-directed mutagenesis.

J Agric Food Chem 2019 Apr 24. Epub 2019 Apr 24.

Maltooligosyltrehalose synthase (MTSase) is a key enzyme in trehalose production. MTSase from Arthrobacter ramosus has poor thermostability, limiting its industrial use. In this study, mutant G415P was obtained by directed evolution, and S361R/S444E was subsequently generated based on a structure analysis of the region around G415. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b01123DOI Listing
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