868,444 results match your criteria Combination Products in Therapy [Journal]


Investigating the physiological mechanisms underlying Salicornia ramosissima response to atmospheric CO enrichment under coexistence of prolonged soil flooding and saline excess.

Plant Physiol Biochem 2018 Dec 6;135:149-159. Epub 2018 Dec 6.

Departamento de Biología Vegetal y Ecología, Facultad de Biología, Universidad de Sevilla, 1095, 41080, Sevilla, Spain.

A 45-days long climatic chamber experiment was design to evaluate the effect of 400 and 700 ppm atmospheric CO treatments with and without soil water logging in combination with 171 and 510 mM NaCl in the halophyte Salicornia ramosissima. In order to ascertain the possible synergetic impact of these factors associate to climatic change in this plant species physiological and growth responses. Our results indicated that elevated atmospheric CO concentration improved plant physiological performance under suboptimal root-flooding and saline conditions plants. Read More

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December 2018

Valorization of microalgal biomass by hydrothermal carbonization and anaerobic digestion.

Bioresour Technol 2018 Dec 4;274:395-402. Epub 2018 Dec 4.

Chemical Engineering Department, Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address:

The potential of hydrothermal carbonization (HTC) as a novel choice for treating microalgal biomass (MAB) was assessed. The hydrochar obtained at 210 °C had a carbon content and a higher heating value (HHV) 1.09 and 1. Read More

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December 2018

Comparing functional dynamic normalization methods to maximal voluntary isometric contractions for lower limb EMG from walking, cycling and running.

J Electromyogr Kinesiol 2018 Dec 1;44:86-93. Epub 2018 Dec 1.

Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada. Electronic address:

There is no consensus on the most appropriate method for normalizing an individual's electromyography (EMG) signals from walking, cycling and running in the same data collection. The aim of this study was to compare how the magnitude and repeatability of normalization values differ from three normalization methods and to compare their scaling effect in three moderate intensity activities. Three rounds of maximal voluntary isometric contractions (MVICs), sprint cycling and sprint running were performed to obtain normalization values for each method. Read More

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December 2018

Molecular systematics of the Triplophysa robusta (Cobitoidea) complex: extensive gene flow in a depauperate lineage.

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Adaptation and Evolution of Plateau Biota, and Laboratory of Plateau Fish Evolutionary and Functional Genomics, and Qinghai Key Laboratory of Animal Ecological Genomics, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, Qinghai, China. Electronic address:

Gene flow between populations assumed to be isolated frequently leads to incorrect inferences of evolutionary history. Understanding gene flow and its causes has long been a key topic in evolutionary biology. In this study, we explored the evolutionary history of the Triplophysa robusta complex, using a combination of multilocus analyses and coalescent simulation. Read More

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December 2018

Integrating multilocus DNA data and 3D geometric morphometrics to elucidate species boundaries in the case of Pyrenaearia (Pulmonata: Hygromiidae).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Zoology and Animal Cell Biology, Faculty of Pharmacy, University of the Basque Country, EHU/UPV, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Araba, Spain; Biodiversity Research Group CIEA Lucio Lascaray, Avda. Miguel de Unamuno 3, 01006, Araba, Spain. Electronic address:

To accurately delimit species the use of multiple character types is essential as all speciation processes are not equally reflected in different data (e.g. morphological, molecular or ecological characters). Read More

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December 2018

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC).

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Melanoma accounts for only 4% of malignant neoplasms of the skin, but is considered the most serious because it is highly deadly. Mutations in the MAPK (Ras-Raf-MEK-ERK) pathway is closely linked to the lack of control of cell proliferation. Especially in melanoma, this pathway has become a target for the development of oncogene-targeted therapies, such as the potent inhibitors of v-Raf murine sarcoma viral oncogene homolog B (BRAFi) and mitogen-activated protein kinase kinase (MEKi). Read More

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December 2018
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Fluoxetine increases analgesic effects of morphine, prevents development of morphine tolerance and dependence through the modulation of L-type calcium channels expression in mice.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, School of Pharmacy, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Neuroanesthesia Laboratory, Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Here, we aimed to investigate the effects of fluoxetine on morphine-induced analgesia, as well as preventive effects of it on morphine induced tolerance and dependence in mice. We also elucidate the involvement of L-type Ca channels in these phenomena. To induce morphine tolerance, mice were treated with morphine (50 mg/kg) for 3 consecutive days. Read More

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December 2018

Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation of immunogenic DLBCL spheroids. Read More

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December 2018

Cyclical Treatment of Colorectal Tumor Spheroids Induces Resistance to MEK Inhibitors.

Transl Oncol 2018 Dec 11;12(3):404-416. Epub 2018 Dec 11.

Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA. Electronic address:

Adaptive drug resistance is a major obstacle to successful treatment of colorectal cancers. Physiologic tumor models of drug resistance are crucial to understand mechanisms of treatment failure and improve therapy by developing new therapeutics and treatment strategies. Using our aqueous two-phase system microtechnology, we developed colorectal tumor spheroids and periodically treated them with sub-lethal concentrations of three Mitogen Activated Kinase inhibitors (MEKi) used in clinical trials. Read More

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December 2018

Centennial records of cadmium and lead in NE China lake sediments.

Sci Total Environ 2018 Nov 28;657:548-557. Epub 2018 Nov 28.

EcoLab - Laboratoire Ecologie Fonctionnelle et Environnement, Université de Toulouse, CNRS, INPT, UPS, 31000 Toulouse, France.

Cores (15 to 40 cm of depth) were collected from 11 lakes of the Songnen Plain in northeastern China to reconstruct changes in potentially harmful trace element (PHTE) inputs as tracers of human activities. In each profile, most PHTE enrichment factors do not differ significantly from the pre-industrial values (EF < 1.5), except for Cd (EF = 2-5. Read More

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November 2018

Combining land preparation and vegetation restoration for optimal soil eco-hydrological services in the Loess Plateau, China.

Sci Total Environ 2018 Dec 3;657:535-547. Epub 2018 Dec 3.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Sediment Research, China Institute of Water Resource and Hydropower Research, Beijing 100048.

In semiarid terrestrial ecosystems, optimized eco-rehabilitation strategies, such as land preparations and planting vegetation, are keys to achieve a successful ecological restoration. Land preparations and vegetation are supposed to have the coupled and respective impacts on soil ecosystem services, which are still unclear now. In this study, eighteen experimental plots with six different combinations and repetitions of land preparations and vegetation were built in the Chinese Loess Plateau in 2014 and soil moisture storages (SMS), soil carbon stocks (SCS) and other soil nutrient stocks were calculated at 0-100 cm, also the effects of land preparations and planting vegetation on soil eco-hydrological services are analyzed by mathematical methods. Read More

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December 2018

Environmental fate of pharmaceutical compounds and antimicrobial-resistant bacteria in hospital effluents, and contributions to pollutant loads in the surface waters in Japan.

Sci Total Environ 2018 Dec 3;657:476-484. Epub 2018 Dec 3.

Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Environmental fate of 58 pharmaceutical compounds (PhCs) grouped into 11 therapeutic classes in the three different waters, hospital effluent, sewage treatment plant (STP) and river water, was estimated by combination of their quantitative concentration analysis and evaluation of their extent of contribution as loading sources. At the same time, distribution of six classes of antimicrobial-resistant bacteria (AMRB) in the same water samples was estimated by screening of individual PhC-resistant microbes grown on each specific chromogenic medium. The results indicate that 48 PhCs were detected ranged from 1 ng/L (losartan carboxylic acid) to 228 μg/L (acetaminophen sulfate) in hospital effluent, and contribution of the pollution load derived from hospital effluent to STP influent was estimated as 0. Read More

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December 2018

The sources and dynamics of fine-grained sediment degrading the Freshwater Pearl Mussel (Margaritifera margaritifera) beds of the River Torridge, Devon, UK.

Sci Total Environ 2018 Nov 28;657:420-434. Epub 2018 Nov 28.

Sustainable Agriculture Sciences Department, Rothamsted Research, North Wyke, Okehampton EX20 2SB, UK.

The Freshwater Pearl Mussel (Margaritifera margaritifera) is an endangered organism across its entire range. It has a complex life cycle and stringent habitat requirements and is therefore an indicator species for the general ecosystem health of host rivers. Whereas historical intensive pearl fishing contributed to population declines, excess nutrient and sediment loss associated with current land use pressures in host river catchments, including modern intensive farming practices, are now highlighted as primary contributory factors. Read More

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November 2018

Integrated chemical exposure assessment of coastal green turtle foraging grounds on the Great Barrier Reef.

Sci Total Environ 2018 Nov 22;657:401-409. Epub 2018 Nov 22.

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall St, Woolloongabba, Qld 4102, Australia.

The Great Barrier Reef receives run-off from 424,000 km catchment area across coastal Queensland, incorporating diffuse agricultural run-off, and run-off point sources of land-based chemical pollutants from urban and industrial development. Marine biota, such as green turtles (Chelonia mydas), are exposed to these diverse chemical mixtures in their natural environments, and the long term effects on turtle and ecosystem health remain unknown. This study was part of a larger multi-disciplinary project characterising anthropogenic chemical exposures from the marine environment and turtle health. Read More

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November 2018

Fog collection as a strategy to sequester carbon in drylands.

Sci Total Environ 2018 Dec 5;657:391-400. Epub 2018 Dec 5.

Department of Agricultural, Food and Forestry Systems (GESAAF), Università degli Studi di Firenze, Florence, Italy. Electronic address:

Advection fog is the sole source of water for many near-the-sea arid areas worldwide such as the lomas, i.e. fog-dependant landscapes of the coastal zone of Peru and Northern Chile, where deforestation occurred since 16th century, leading to a progressive and severe desertification. Read More

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December 2018

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit resistivity towards various classes of antibiotics that shows that there is a dire need to search more drug targets by exploiting the full genome of the bacteria. Read More

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December 2018

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment.

Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More

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December 2018

Response of the Injured Tendon to Growth Factors in the Presence or Absence of the Paratenon.

Am J Sports Med 2018 Dec 14:363546518814534. Epub 2018 Dec 14.

Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota, USA.

Background:: The paratenon is important for Achilles tendon healing. There is much interest in the use of exogenous growth factors (GFs) as potential agents for accelerating the healing of damaged Achilles tendons.

Purpose/hypothesis:: The present study used a rat model to study the responses of the injured Achilles tendon to GFs in the presence or absence of the paratenon. Read More

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December 2018

Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells.

Cell Microbiol 2018 Dec 14:e12992. Epub 2018 Dec 14.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Read More

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December 2018

A review of lifestyle, metabolic risk factors and blood-based biomarkers for early diagnosis of pancreatic ductal adenocarcinoma.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health|, University of Oxford, Oxford, UK.

We aimed to review the epidemiologic literature examining lifestyle, metabolic risk factors, and blood-based biomarkers including multi-omics (genomics, proteomics, and metabolomics) and to discuss how these predictive markers can inform early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A search of the PubMed database was conducted in June 2018 to review epidemiologic studies of (1) lifestyle and metabolic risk factors for PDAC, genome-wide association studies (GWAS), and risk prediction models incorporating these factors and (2) blood-based biomarkers for PDAC (conventional diagnostic markers, metabolomics, and proteomics). Prospective cohort studies have reported at least twenty possible risk factors for PDAC, including smoking, heavy alcohol drinking, adiposity, diabetes, and pancreatitis, but the relative risks (RR) and population attributable fractions of individual risk factors are small (mostly <10%). Read More

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December 2018

The human visual system estimates angle features in an internal reference frame: A computational and psychophysical study.

J Vis 2018 Dec;18(13):10

Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Angle perception is an important middle-level visual process, combining line features to generate an integrated shape percept. Previous studies have proposed two theories of angle perception-a combination of lines and a holistic feature following Weber's law. However, both theories failed to explain the dual-peak fluctuations of the just-noticeable difference (JND) across angle sizes. Read More

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December 2018

Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality.

PLoS One 2018 14;13(12):e0208847. Epub 2018 Dec 14.

Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova de Lleida,IRBLleida, Universitat de Lleida, Lleida, Catalonia, Spain.

Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless of their potential impact on short-term adverse outcomes.

Methods: This was a longitudinal, retrospective study of all patients >40 years old admitted to the ED of two Spanish teaching hospitals for an AECOPD between January 1st and May 31st, 2016. All data were collected from electronic medical records. Read More

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December 2018

Phenology of Trichodesmium spp. blooms in the Great Barrier Reef lagoon, Australia, from the ESA-MERIS 10-year mission.

PLoS One 2018 14;13(12):e0208010. Epub 2018 Dec 14.

Commonwealth Scientific and Industrial Research Organization (CSIRO), Canberra, Australia.

Trichodesmium, a filamentous bloom-forming marine cyanobacterium, plays a key role in the biogeochemistry of oligotrophic ocean regions because of the ability to fix nitrogen. Naturally occurring in the Great Barrier Reef (GBR), the contribution of Trichodesmium to the nutrient budget may be of the same order as that entering the system via catchment runoff. However, the cyclicity of Trichodesmium in the GBR is poorly understood and sparsely documented because of the lack of sufficient observations. Read More

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December 2018

Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty.

PLoS One 2018 14;13(12):e0205810. Epub 2018 Dec 14.

Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.

Objective: To compare the serum inhibin B, anti-Müllerian hormone (AMH) and leptin concentrations in girls with idiopathic central precocious puberty (CPP) to their concomitant characteristics and evaluate the capacity of each of these hormones to predict the age at first menstruation in those who were untreated and who completed their puberty.

Methods: This single-center study included 94 girls selected from a cohort of 493 girls seen between 1981 and 2012 and diagnosed with idiopathic CPP for whom a remaining serum sample collected at the initial evaluation was available. Of these 25 were untreated and completed their puberty. Read More

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December 2018

A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates.

PLoS One 2018 14;13(12):e0209038. Epub 2018 Dec 14.

Department of Clinical Microbiology, Virology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.

Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal, urogenital, and ocular infections. They are divided into seven species containing 85 genotypes. Straightforward typing systems might help epidemiological investigations. Read More

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December 2018

Determining diet from faeces: Selection of metabarcoding primers for the insectivore Pyrenean desman (Galemys pyrenaicus).

PLoS One 2018 14;13(12):e0208986. Epub 2018 Dec 14.

Department of Zoology and Animal Cell Biology, University of the Basque Country UPV/EHU, Leioa, Basque Country, Spain.

Molecular techniques allow non-invasive dietary studies from faeces, providing an invaluable tool to unveil ecological requirements of endangered or elusive species. They contribute to progress on important issues such as genomics, population genetics, dietary studies or reproductive analyses, essential knowledge for conservation biology. Nevertheless, these techniques require general methods to be tailored to the specific research objectives, as well as to substrate- and species-specific constraints. Read More

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December 2018

Combined therapy with levothyroxine and liothyronine for hypothyroidism.

Medwave 2018 Dec 14;18(8):e7376. Epub 2018 Dec 14.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit. Read More

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December 2018

Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S75-S92

Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia (C.J.R.S.) Department of Pathology, Brigham and Women's Hospital (C.P.C.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK (W.G.M.) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, New York (K.J.P.) Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California (J.K.R.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Pathological Oncology Group and Pathology Department, Hospital Arnau de Vilanova, Lleida, Spain (X.M.-G.) Departments of Pathology and Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland (B.M.R.).

In most cases of suspected endometrial neoplasia tumor origin can be correctly assigned according to a combination of clinical, radiologic, and pathologic features, even when the latter are based upon the examination of relatively small biopsy samples. However there are well-recognized exceptions to this rule which continue to create diagnostic difficulty, and sometimes difficulties persist even after the detailed examination of resection specimens. Among the most common problems encountered in practice are the distinction of primary endometrial and primary endocervical adenocarcinomas, and the determination of tumor origin when there is synchronous, multifocal involvement of gynecologic tract sites, for example the endometrium and the ovary. Read More

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January 2019

Combination of ω-3 fatty acids and cisplatin as a potential alternative strategy for personalized therapy of metastatic melanoma: an in-vitro study.

Melanoma Res 2018 Dec 13. Epub 2018 Dec 13.

Institute of General Pathology, Università Cattolica del Sacro Cuore.

The recently developed therapeutic strategies have led to unprecedented improvements in the control of metastatic melanoma and in the survival of specific subgroups of patients. However, drug resistance, low response rates, and undesired side effects make these treatments not suitable or tolerable for all the patients, and chemotherapeutic treatments appear still indispensable, at least for subgroups of patients. New combinatory strategies are also under investigation as tailored treatments or salvage therapies, including combined treatments of immunotherapy with conventional chemotherapy. Read More

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December 2018

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes.

Curr Med Res Opin 2018 Dec 14:1-21. Epub 2018 Dec 14.

d National Research Institute , Los Angeles , CA , USA .

Objective: The LixiLan clinical trials of insulin glargine (iGlar)/lixisenatide fixed-ratio combination (iGlarLixi) investigated the safety and efficacy of iGlarLixi versus iGlar: LixiLan-O (NCT02058147) in patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetes drugs (OADs), and LixiLan-L (NCT02058160) in patients with T2D inadequately controlled on basal insulin ± OADs. In these two trials, both iGlar and iGlarLixi were titrated to a maximum (capped) dose of 60 units. We evaluated whether this may have affected the reported glycemic efficacy of iGlar, and the glycemic differences observed between treatment with iGlarLixi and iGlar. Read More

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December 2018

Towards Building Protein Force Fields by Residue-based Systematic Molecular Fragmentation and Neural Network.

J Chem Theory Comput 2018 Dec 14. Epub 2018 Dec 14.

Accurate force fields are crucial for molecular dynamics investigation of complex biological systems. Building accurate protein force fields from quantum mechanical (QM) calculations is challenging due to the complexity of proteins and high computational costs of QM methods. In order to overcome these two difficulties, here we developed the residue-based systematic molecular fragmentation method to partition general proteins into only twenty types of amino acid dipeptides and one type of peptide bond at Level 1. Read More

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December 2018

Three-Dimensional Superlattices Based on Unusual Chalcogenide Supertetrahedral In-Sn-S Nanoclusters.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou , Jiangsu 215123 , China.

Reported here are two novel metal chalcogenide superlattices built from unusual supertetrahedral TO2-InSnS clusters. With regard to only one previously reported case of a TO2-InS-based 2D-layered structure, such a combination of In-Sn-S components is thought to be reasonable for leading to the first observation of 3D superlattices based on TO2-InSnS clusters. Besides, these title semiconducting materials also display good performance on the electrocatalytic oxygen reduction reaction. Read More

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December 2018

Diastereoselective Photooxidation and Reduction of Chiral Iridium(III) Complexes.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry , Sun Yat-sen University , Guangzhou 510275 , China.

A diastereoselective photooxidation of α-amino acid (AA) complexes into imino acid complexes using a chiral iridium(III) complex as a photosensitizer and stereo-controller under visible light irradiation and oxygen was developed. It was found that the oxidative rate of Δ-[Ir(pq)( L-AA)] (pq is 2-phenylquinoline) diastereomer is significantly higher than that of the corresponding Δ-[Ir(pq)( D-AA)] diastereomer, providing a new protocol for kinetic resolution of AAs via a nonenzymatic pathway. Moreover, the thermodynamic controlled strategy offered a complemental method for the diastereoselective hydrogenation of imine bonds using NaBH as a reductant under the chiral Ir(III) complex as a stereo-controller. Read More

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December 2018

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

ACS Nano 2018 Dec 14. Epub 2018 Dec 14.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

Prodrug strategies that facilitate localized and controlled activity of small-molecule therapeutics can reduce systemic exposure and improve pharmacokinetics, yet limitations in activation chemistry have made it difficult to assign tunable multifunctionality to prodrugs. Here, we present the design and application of a modular small-molecule caging strategy that couples bioorthogonal cleavage with a self-immolative linker and an aliphatic anchor. This strategy leverages recently discovered in vivo catalysis by a nanoencapsulated palladium compound (Pd-NP), which mediates alloxylcarbamate cleavage and triggers release of the activated drug. Read More

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December 2018

Emodin Reduces the Activity of (1,3)--D-glucan Synthase from and Does Not Interact with Caspofungin.

Authors:
Monika Janeczko

Pol J Microbiol 2018 ;67(4):463-470

Department of Molecular Biology, The John Paul II Catholic University of Lublin , Lublin , Poland.

Candidiasis is the most common opportunistic yeast infection, with Candida albicans as a paramount causative species. (1,3)- β -D-glucan is one of the three main targets of clinically available antifungal agents used to treat Candida infections. It is one of the most abundant fungal cell wall components. Read More

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January 2018

[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1783-1787

Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, China.

To observe the clinical efficacy of nasal corticosteroids combined with nasal antihistamine in the treatment of vasomotor rhinitis. One hundred and twenty vasomotor rhinitis patients were randomly divided into three groups including budesonide group, azelastine group, and budesonide and azelastine group with 40 cases in each. Nasal spray with nasal corticosteroids and nasal antihistamines was applied for combined treatment group, while the patients in budesonide group and azelastine group were given only nasal corticosteroids and nasal antihistamines, respectively. Read More

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December 2018

[The effect of the nasal packing material on nasal epithelial cells].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1900-1903

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730,China.

The aim of this study is to investigate the effect of polyethylene glycol acrylate hybrid hydrogel degradation substance on nasal mucociliary transport system. In our experiment, the complex hydrogel were formed by the combination of different ratios of polyethyleneglycol diacrylate, chitosan and polyvinyl alcohol. The experiment was divided into four groups according to the international standard of medical devices. Read More

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December 2018
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[The experience in the application of nikavir in the schemes of perinatal chemoprophylactics of HIV infection: evaluation of the immunological and virusological effectiveness.]

Vopr Virusol 2018 ;63(5):212-217

Academician Ye. A. Wagner State Medical University, Perm, 614000, Russian Federation.

Objectives: The goal of this work was to study the immunological and virological efficacy of the domestic antiretroviral drug nicavir (at the optimal dose, as proven by previous clinical studies) with lamivudine, in comparison with other drugs of the group of nucleoside reverse transcriptase inhibitors in combination with kaletra in perinatal HIV chemoprophylaxis regimens.

Methods: 658 pregnant women aged 16-39 years and children born to them were examined. The first group (281 people) and the third group (66 people) received the nicavir (manufactured by AZT PHARMA KB LLC) with lamivudine in combination with calyx; the second (281 people) and the fourth (30 people) of the comparison group, stag and zidovudine, respectively, with lamivudine in combination with calyx. Read More

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January 2018

[Efficacy of SUPRA HFR in the treatment of acute renal damage during multiple myeloma].

G Ital Nefrol 2018 Dec;35(6)

S.C. Nefrologia, Dialisi e Trapianto U. AOU Città della Salute e della Scienza di Torino, Torino, Italia.

Acute Kidney Injury (AKI) is a frequent complication of multiple myeloma (MM) with unfavorable prognostic significance. Light chains removal, combined with hematological therapy (CT) seems to offer significant benefits to renal function recovery (RFR). The SUPRA HFR, through the combination of high cut-off membrane without albumin loss and adsorbent cartridge, represents one of the "emerging" light chain removal methods. Read More

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December 2018

A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node.

Clin Lab 2018 Oct;64(11)

Background: Castleman disease (CD) is a lymphoproliferative disorder and Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage system. The authors describe a rare case of CD coexistent with LCH at diagnosis in one lymph node. Methods: Hematologic investigation and intrapulmonary mass biopsy were performed. Read More

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October 2018
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Combination Surgery of Silicone Tube Intubation and Conjunctival Resection in Patients with Epiphora.

Korean J Ophthalmol 2018 Dec;32(6):438-444

Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea.

Purpose: To compare the success rates of performing only silicone tube intubation versus carrying out both conjunctival resection and silicone tube intubation.

Methods: The subjects of this study involved 62 patients (96 eyes) between October 2015 and May 2017 who were diagnosed as having punctal stricture or nasolacrimal duct stenosis. Out of 96 eyes, 47 underwent only silicone tube intubation, and 49 underwent both silicone tube intubation and conjunctival resection. Read More

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December 2018

Macromolecular crowding as a means to assess the effectiveness of chondrogenic media.

J Tissue Eng Regen Med 2018 Dec 14. Epub 2018 Dec 14.

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.

Chondrocyte-based tissue engineering requires in vitro cell expansion, which is associated with phenotypic losses, decrease in collagen II synthesis and increase in collagen I synthesis. Another major obstacle in clinical translation of chondrocyte-based therapies is the lack of extracellular matrix (ECM) in the engineered cartilage substitutes. Various research and commercially available media claim that can maintain chondrogenic phenotype, whilst macromolecular crowding (MMC) has been shown to increase tissue-specific ECM deposition and to maintain cell phenotype in vitro. Read More

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December 2018

Dual blockade of the PI3K/Akt/mTOR pathway inhibits post-transplant Epstein-Barr virus B cell lymphomas and promotes allograft survival.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation that often manifests as Epstein-Barr virus (EBV)-associated B cell lymphomas. Current treatments for PTLD have limited efficacy and can be associated with graft rejection or systemic toxicities. The mTOR inhibitor, rapamycin, suppresses tumor growth of EBV+ B cell lymphoma cells in vitro and in vivo; however, the efficacy is limited and clinical benefits of mTOR inhibitors for PTLD are variable. Read More

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December 2018

A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neutrophil extracellular traps (NETs) are web-like structures composed of decondensed chromatin and antimicrobial proteins that are released into the extracellular space during microbial infections. This active cell death program is known as NETosis. To date, florescence microscopy is the widely accepted method for visualization and quantification of NETs. Read More

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December 2018

Open Microsurgical Dorsal Root Ganglion Lead Placement.

Neuromodulation 2018 Dec 14. Epub 2018 Dec 14.

Department of Stereotactic and Functional Neurosurgery, Heinrich-Heine University, Düsseldorf, Germany.

Introduction: Dorsal root ganglion stimulation (DRG) is a new but well-established neuromodulation technique allowing new indications and superiority to pre-existing stimulation techniques such as spinal cord stimulation in selected pain etiologies. Previous surgical procedures in the implantation area pose a challenge for the percutaneous technique and are therefore considered contraindications for DRG stimulation surgery. We describe the successful open DRG electrode placement in two patients with previous surgeries suffering from severe radiculopathy due to foraminal stenosis. Read More

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December 2018

Contemporary management of primary parapharyngeal space tumors.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Coordinator of the International Head and Neck Scientific Group.

The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. Read More

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December 2018

Ultrahigh-Sensitive Broadband Photodetectors Based on Dielectric Shielded MoTe /Graphene/SnS p-g-n Junctions.

Adv Mater 2018 Dec 14:e1805656. Epub 2018 Dec 14.

Department of Physics, Southern University of Science and Technology, Shenzhen, 518055, China.

2D atomic sheets of transition metal dichalcogenides (TMDs) have a tremendous potential for next-generation optoelectronics since they can be stacked layer-by-layer to form van der Waals (vdW) heterostructures. This allows not only bypassing difficulties in heteroepitaxy of lattice-mismatched semiconductors of desired functionalities but also providing a scheme to design new optoelectronics that can surpass the fundamental limitations on their conventional semiconductor counterparts. Herein, a novel 2D h-BN/p-MoTe /graphene/n-SnS /h-BN p-g-n junction, fabricated by a layer-by-layer dry transfer, demonstrates high-sensitivity, broadband photodetection at room temperature. Read More

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December 2018

Understanding assessment on a hospital ward for older people: a qualitative study.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Warwick Research in Nursing, University of Warwick and Oxford Trauma, Kadoorie Centre, NDORMS, University of Oxford and Oxford University Hospitals NHS Trust.

Aim: To explore assessment on a hospital ward for older people from the perspectives of patients and healthcare professionals.

Design: A qualitative study drawing on grounded theory was undertaken between February 2015 - January 2016.

Methods: Interviews with 15 patients and 22 healthcare professionals, a focus group with six healthcare professionals, 45 hours of observation and review of 18 sets of patient notes. Read More

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December 2018

Treating Osteosarcoma with CAR T cells.

Scand J Immunol 2018 Dec 14:e12741. Epub 2018 Dec 14.

Laboratory of Translational Research & Immunomonitoring, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.

Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop Chimeric Antigen Receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. Read More

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December 2018
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