9,951 results match your criteria Colposcopy

False Negative Results in Cervical Cancer Screening-Risks, Reasons and Implications for Clinical Practice and Public Health.

Diagnostics (Basel) 2022 Jun 20;12(6). Epub 2022 Jun 20.

Department of Cancer Prevention, The Maria Sklodowska-Curie National Research Institute of Oncology, Roentgen Street 5, 02-781 Warsaw, Poland.

False negative (FN) results in cervical cancer (CC) screening pose serious risks to women. We present a comprehensive literature review on the risks and reasons of obtaining the FN results of primary CC screening tests and triage methods and discuss their clinical and public health impact and implications. Misinterpretation or true lack of abnormalities on a slide are the reasons of FN results in cytology and p16/Ki-67 dual-staining. Read More

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Using the Consolidated Framework for Implementation Research to Inform the Design of the Mobile Inspección Visual con Ácido Acético System: Mixed Methods Case Study.

JMIR Form Res 2022 Jun 23;6(6):e32577. Epub 2022 Jun 23.

Duke University School of Medicine, Durham, NC, United States.

Background: There is growing evidence supporting the use of mobile health (mHealth) interventions in low- and middle-income countries to address resource limitations in the delivery of health information and services to vulnerable populations. In parallel, there is an increasing emphasis on the use of implementation science tools and frameworks for the early identification of implementation barriers and to improve the acceptability, appropriateness, and adoption of mHealth interventions in resource-limited settings. However, there are limited examples of the application of implementation science tools and frameworks to the formative phase of mHealth design for resource-limited settings despite the potential benefits of this work for enhancing subsequent implementation, scale-up, and sustainability. Read More

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Simplified Convolutional Neural Network Application for Cervix Type Classification via Colposcopic Images.

Bioengineering (Basel) 2022 May 30;9(6). Epub 2022 May 30.

Personalised Medicine Centre, 197341 St. Petersburg, Russia.

The inner parts of the human body are usually inspected endoscopically using special equipment. For instance, each part of the female reproductive system can be examined endoscopically (laparoscopy, hysteroscopy, and colposcopy). The primary purpose of colposcopy is the early detection of malignant lesions of the cervix. Read More

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Cervix Type and Cervical Cancer Classification System Using Deep Learning Techniques.

Med Devices (Auckl) 2022 16;15:163-176. Epub 2022 Jun 16.

Biomedical Imaging Unit, School of Biomedical Engineering, Jimma Institute of Technology, Jimma University, Jimma, Ethiopia.

Purpose: Cervical cancer is the 4th most common cancer among women, worldwide. Incidence and mortality rates are consistently increasing, especially in developing countries, due to the shortage of screening facilities, limited skilled professionals, and lack of awareness. Cervical cancer is screened using visual inspection after application of acetic acid (VIA), papanicolaou (Pap) test, human papillomavirus (HPV) test and histopathology test. Read More

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The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions.

Int J Gynecol Cancer 2022 Jun 21. Epub 2022 Jun 21.

Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vulvar squamous intraepithelial neoplasia, vulvar Paget disease in situ, and melanoma in situ. For differentiated vulvar intraepithelial neoplasia (dVIN), an excisional procedure must always be adopted. For vulvar high-grade squamous intraepithelial lesion (VHSIL), both excisional procedures and ablative ones can be used. Read More

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Patient choice may improve adherence to follow-up in cervical screening: a randomised-control trial.

N Z Med J 2022 Feb 25;135(1550):146-156. Epub 2022 Feb 25.

FRANZCOG, Gynaecologic Oncologist at Christchurch Women's Hospital.

Aims: We investigated whether patient choice of follow-up type improves health-related quality of life (HrQOL) and follow-up attendance in women who have undergone large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia grade 2 to 3 (CIN 2-3).

Methods: A three-armed randomised controlled trial including women with newly diagnosed CIN 2-3 post-LLETZ treatment was performed. Consenting women were randomised (1:1:1) to either: (a) colposcopy review at the hospital, (b) follow-up with high-risk human papilloma virus (HrHPV) and smear test in the community or (c) a choice of the aforementioned follow-up options, six months post-treatment. Read More

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February 2022

Increased detection of high grade CIN, when using electrical impedance spectroscopy as an adjunct to routine colposcopy, is maintained when used across international boundaries: Prospective data from nine European countries.

Eur J Obstet Gynecol Reprod Biol 2022 Jun 1;275:41-45. Epub 2022 Jun 1.

Medical Physics Group, Department of, Infection, Immunity and Cardiovascular Science, The University of Sheffield, UK.

Objective: To evaluate the performance of EIS (ZedScan) with colposcopy in the detection of high grade CIN (HG-CIN) in different health care settings.

Method: Pooled analysis of data from 26 colposcopy centres in 9 countries. All women underwent colposcopy and ZedScan examination. Read More

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Feasibility and Acceptability of Tele-Colposcopy on the Caribbean Coast of Nicaragua: A Descriptive Mixed-Methods Study.

Telemed Rep 2021 5;2(1):264-272. Epub 2021 Nov 5.

University of Virginia School of Medicine, University of Virginia Center for Global Health, Charlottesville, Virginia, USA.

Cervical cancer, a preventable cancer of disparities, is the primary cause of cancer death for women in Nicaragua. Clinics and personnel in rural and remote Nicaragua may not be accessible to perform recommended screening or follow-up services. To assess acceptability and feasibility of integrating innovations for high-quality screening and treatment follow-up (tele-colposcopy) into existing pathways on Nicaragua's Caribbean Coast within the context of the National Cervical Cancer Control Program. Read More

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November 2021

Evaluation of P16/Ki67 (CINtecPlus) and L1-capsid compared with HPV-genotyping in cervical cytology in women ≥35 years old focusing on patients with atypical squamous cells of undetermined significance.

Oncol Lett 2022 Jul 2;24(1):242. Epub 2022 Jun 2.

Department of Pathology, Institute for Pathology and Cytology (IPN), D-48465 Schuettorf, Germany.

Cervical cancer is the third most common cancer in women worldwide. Conventional cytological examination as a screening method with Papanicolaou has been established to reduce the incidence of dysplasia and cervical cancer for years. In addition to the conventional screening, the introduction of immunocytochemical examinations, including CINtecPlus and L1-capsid, has been demonstrated to have a positive impact on screening results. Read More

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Development of a prognostic prediction support system for cervical intraepithelial neoplasia using artificial intelligence-based diagnosis.

J Gynecol Oncol 2022 May 16. Epub 2022 May 16.

Statistical Genetics Team, RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.

Objective: Human papillomavirus subtypes are predictive indicators of cervical intraepithelial neoplasia (CIN) progression. While colposcopy is also an essential part of cervical cancer prevention, its accuracy and reproducibility are limited because of subjective evaluation. This study aimed to develop an artificial intelligence (AI) algorithm that can accurately detect the optimal lesion associated with prognosis using colposcopic images of CIN2 patients by utilizing objective AI diagnosis. Read More

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Chronic Cervicitis and Cervical Cancer Detection Based on Deep Learning of Colposcopy Images Toward Translational Pharmacology.

Front Pharmacol 2022 27;13:911962. Epub 2022 May 27.

Department of Dermatology, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, China.

With the rapid development of deep learning, automatic image recognition is widely used in medical development. In this study, a deep learning convolutional neural network model was developed to recognize and classify chronic cervicitis and cervical cancer. A total of 10,012 colposcopy images of 1,081 patients from Hunan Provincial People's Hospital in China were recorded. Read More

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Predictors of depressive symptoms before and after diagnostic procedures in women with abnormal Pap smear attending cervical cancer screening programme in Serbia.

Eur J Cancer Care (Engl) 2022 Jun 13:e13634. Epub 2022 Jun 13.

Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Objectives: Receipt of a positive Papanicolaou screening result and subsequent referral for diagnostic tests can cause psychological stress. Still, not enough is known about depression before and after the diagnostic test in these women. The aim of this study was to determine the burden and predictors of depressive symptoms prior to and after diagnostic investigations in women who had received a positive Papanicolaou screening result. Read More

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Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions.

Front Oncol 2022 18;12:812076. Epub 2022 May 18.

Department of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: This study aimed to compare the variability of HPV16/18/52/58 subtype infections in patients with different cervical lesions, to explore the guiding significance of persistent positive HPV subtypes 52 and 58 in the stratified management of cervical lesions, and to determine the appropriate management model.

Method: This study was conducted through a retrospective analysis of 244,218 patients who underwent HPV testing at the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University from September 2014 to December 2020 to examine the distribution of different types of HPV infection. From March 2015 to September 2017, 3,014 patients with known HPV underwent colposcopy to analyze high-risk HPV infection for different cervical lesions. Read More

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[Global guidelines for cervical cancer and precancerous lesions treatment: a systematic review].

Zhonghua Yi Xue Za Zhi 2022 Jun;102(22):1666-1676

Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To systematically summarize current status and recommendations of the global cervical cancer and precancerous lesions treatment guidelines. The retrieval for all the Chinese and English literature published before July 8, 2021 was conducted in PubMed, Embase, SinoMed Database, CNKI and Wanfang Database, supplemented by a search of health websites of countries worldwide, with"uterine cervical neoplasms""cervix cancer""cervical neoplasm""cervical precancerous lesions""treat*""guideline*""practice guideline*""consensus" "recommendation*""guidebook*"in English as well as"cervical precancerous lesions""cervical neoplasm""treatment""guideline*""consensus"in Chinese as search keywords. A total of 38 guidelines were included for data extraction and analysis. Read More

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Clinical correlation of cervical cancer screening using Pap smear test.

J Popul Ther Clin Pharmacol 2022 15;29(1):e1-e8. Epub 2022 Feb 15.

Department of Obstetrics and Gynecology, College of Medicine, University of Al-Qadisiyah, Al-Diwaniyah, Iraq;

Background And Objectives: Cervical cancer (CC) has a long preinvasive stage, which allows for preventive detection and possible cure. In this study, this stage was a target stage to investigate women with precancerous lesions by applying the Papanicolaou (Pap) smear test and comduct performing a correlation study.s. Read More

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Clinical utility of p16/Ki67 dual-stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: A cross-sectional study.

BJOG 2022 Jun 10. Epub 2022 Jun 10.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Objective: To evaluate the clinical utility of p16/Ki67 dual-stain (DS) compared with cytology for detecting cervical intraepithelial lesion grade two or worse (CIN2+) in women with a transformation zone type 3 (TZ3).

Design: Cross-sectional study.

Setting: Colposcopy clinics in Central Denmark Region. Read More

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Innovative Diagnostic and Therapeutic Interventions in Cervical Dysplasia: A Systematic Review of Controlled Trials.

Cancers (Basel) 2022 May 27;14(11). Epub 2022 May 27.

Department of Gynecology and Obstetrics, Ruhr-Universität Bochum, Marien Hospital Herne, 44625 Herne, Germany.

Cervical dysplasia is a common precancerous lesion affecting 1% to 2% of women worldwide. Significant progress in the diagnosis and treatment of cervical dysplasia have been made in the last decade. We performed a systematic literature search of the databases PubMed and Cochrane Central Register of Controlled Trials to identify controlled clinical trials reporting on the efficacy and safety of diagnostic and therapeutic interventions for cervical dysplasia. Read More

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The gray zone squamous lesions: ASC-US / ASC-H.

Cytojournal 2022 30;19:30. Epub 2022 Apr 30.

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

The unequivocal and easily recognizable entities of LSIL and HSIL pose no diagnostic problems for a trained eye. However, when the defining morphologic features are either qualitatively or quantitatively insufficient, it is then that the borderline category of "Atypical Squamous cells" (ASC) may have to be used. Scant and suboptimal preparations (mainly in conventional smears) are the common causes that hinder confident decision-making. Read More

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Natural Language Processing to Identify Abnormal Breast, Lung, and Cervical Cancer Screening Test Results from Unstructured Reports to Support Timely Follow-up.

Stud Health Technol Inform 2022 Jun;290:433-437

Department of General Internal Medicine, Brigham and Women's Hospital, Boston, MA, United States.

Cancer screening and timely follow-up of abnormal results can reduce mortality. One barrier to follow-up is the failure to identify abnormal results. While EHRs have coded results for certain tests, cancer screening results are often stored in free-text reports, which limit capabilities for automated decision support. Read More

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Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraepithelial lesion: APRICITY phase 3 study protocol.

BMJ Open 2022 Jun 6;12(6):e061740. Epub 2022 Jun 6.

Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany

Introduction: High-risk human papilloma virus (HPV)-associated cervical cancer is the fourth most common cancer in women worldwide. Current treatments of high-grade squamous intraepithelial lesion (HSIL) of the cervix are based on invasive surgical interventions, compromising cervical competence and functionality. APRICITY is a multicentre, prospective, double-blind, randomised controlled phase 3 study further evaluating the efficacy and safety of Cevira, an integrated drug-delivery and light-delivery device for hexaminolevulinate photodynamic therapy, which shows promise as a novel, non-invasive outpatient therapy for women with HSIL. Read More

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Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women.

Br J Gen Pract 2022 Apr 7. Epub 2022 Apr 7.

School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

Background: Cervical cancer incidence and mortality are high in women aged ≥65 years, despite the disease being preventable by screening. Speculum-based screening can become more uncomfortable after the menopause.

Aim: To examine test performance and acceptability of human papillomavirus (HPV) testing on clinician-collected vaginal samples without a speculum (non-speculum). Read More

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Evaluation of FAM19A4/miR124-2 methylation performance in the management of CIN3 diagnosed pregnant women.

Int J Cancer 2022 Jun 6. Epub 2022 Jun 6.

Department of Obstetrics and Gynecology, University Medical Center Hannover, Hannover, Germany.

Pregnant women diagnosed with CIN3 have high regression rates after delivery. Biomarkers are needed to only identify pregnant women with progressive CIN requiring treatment to reduce overreferral and overtreatment. In our study we evaluated the performance of the FAM19A4/miR124-2 methylation test for molecular triage on FFPE samples of CIN3+-diagnosed pregnant women with known clinical course over time as well in a cross-sectional setting. Read More

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Molecular Epidemiology of Human Papillomavirus Infection Among Chinese Women With Cervical Cytological Abnormalities.

Front Public Health 2022 17;10:820517. Epub 2022 May 17.

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Background: Virtually all invasive cervical cancers are caused by persistent genital human papillomavirus (HPV) infection. Therefore, HPV-based screening becomes an essential tool as one of the cervical prevention strategies to reduce the disease burden. Population-specific epidemiologic information on HPV infection among women with cytological abnormalities is essential to inform the strategy of HPV-based screening programme. Read More

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Extended human papillomavirus genotyping to predict progression to high-grade cervical precancer: A prospective cohort study in the southeastern United States.

Cancer Epidemiol Biomarkers Prev 2022 Jun 2. Epub 2022 Jun 2.

University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Background: High-risk human papillomavirus (hrHPV) testing is utilized in primary cervical cancer screening, generally along with cytology, to triage abnormalities to colposcopy. Most screening-based hrHPV testing involves pooled detection of any hrHPV or of HPV16/18. Cervical neoplasia progression risks based on extended hrHPV genotyping-particularly non-16/18 hrHPV types-are not well characterized. Read More

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Is Endocervical Glandular Involvement Related to The Depth of Cone Biopsy?

Int J Surg Pathol 2022 Jun 1:10668969221102616. Epub 2022 Jun 1.

University of Health Sciences, Department of Pathology, 147023Zeynep Kamil Women's and Children's Disease Training and Research Hospital, Istanbul, Turkey.

This study aimed to determine whether endocervical glandular involvement by squamous intraepithelial lesion would differ with respect to the depth of the excised specimen and analyze the related factors that may define endocervical glandular involvement among cases treated with cone biopsy. Between April 2016 and December 2018, women who underwent colposcopy and excisional procedures in the department of gynecologic oncology were retrospectively investigated. Patients with multiple specimens, or whose specimen depths were not measured, and a negative/unknown HPV status were excluded from the study. Read More

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Performance of cervical screening a decade following HPV vaccination: The Costa Rica Vaccine Trial.

J Natl Cancer Inst 2022 May 31. Epub 2022 May 31.

Agencia Costarricense de Investigaciones Biomédicas, ACIB, Fundación INCIENSA, San José, Costa Rica.

Background: We investigated the impact of HPV vaccination on the performance of cytology-based and HPV-based screening for detection of cervical precancer among women vaccinated as young adults and reaching screening age.

Methods: A total of 4632 women aged 25-36 years from the Costa Rica HPV Vaccine Trial were included (2418 HPV-vaccinated as young adults and 2214 unvaccinated). We assessed the performance of cytology- and HPV-based cervical screening modalities in vaccinated and unvaccinated women to detect high-grade cervical precancers diagnosed over four years, and the absolute risk of cumulative cervical precancers by screening results at entry. Read More

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Extension of cervical screening intervals with primary human papillomavirus testing: observational study of English screening pilot data.

BMJ 2022 05 31;377:e068776. Epub 2022 May 31.

Division of Cancer Sciences, University of Manchester, Manchester, UK.

Objectives: To provide updated evidence about the risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) and cervical cancer after a negative human papillomavirus (HPV) test in primary cervical screening, by age group and test assay.

Design: Observational study.

Setting: Real world data from the English HPV screening pilot's first and second rounds (2013-16, follow-up to end of 2019). Read More

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and Supplementation Combined with Vaginal Hyaluronic Acid to Boost the Remission of Cervical Low-Grade Squamous Intraepithelial Lesions (L-SILs): A Randomized Controlled Trial.

Medicina (Kaunas) 2022 May 9;58(5). Epub 2022 May 9.

Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

: and purpurea have known immunomodulatory effects which boost viral clearance, including HPV infection. However, evidence regarding the improvement due to Echinacea-based supplements of cervical HPV-related pathologies is still lacking. The aim of this study is to evaluate the efficacy of Echinacea supplementation on the remission of cervical low-grade squamous intraepithelial lesions (L-SIL). Read More

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