8,797 results match your criteria Colposcopy


Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses.

BMJ 2018 Dec 5;363:k4823. Epub 2018 Dec 5.

Global Coalition Against Cervical Cancer, Durham, NC, USA.

Objective: To evaluate the diagnostic accuracy of high-risk human papillomavirus (hrHPV) assays on self samples and the efficacy of self sampling strategies to reach underscreened women.

Design: Updated meta-analysis.

Data Sources: Medline (PubMed), Embase, and CENTRAL from 1 January 2013 to 15 April 2018 (accuracy review), and 1 January 2014 to 15 April 2018 (participation review). Read More

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December 2018

Clarification for Reported Colposcopy Rates.

Authors:

JAMA 2018 Dec;320(21):2273

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December 2018
4 Reads

Identifying Barriers to Treatment for Women With Cervical Dysplasia in Rural Northern British Columbia.

J Obstet Gynaecol Can 2018 Nov 29;40(11):1401-1408. Epub 2018 Jun 29.

Northern Medical Program, University of British Columbia, Prince George, BC; Women's Health Research Institute, Vancouver, BC; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC. Electronic address:

Objective: This study seeks to identify barriers to colposcopy examination faced by patients living in Northern BC to improve outcomes for women at risk of developing cervical cancer.

Methods: A retrospective chart review (n = 309) was conducted in the four colposcopy clinics in Northern BC to collect information regarding patients who were referred for colposcopy after abnormal cytology. Demographic factors associated with non-attendance were identified as barriers to accessing care. Read More

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November 2018
5 Reads

Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang.

BMC Cancer 2018 Nov 23;18(1):1162. Epub 2018 Nov 23.

Department of Gynecology, Xinjiang Uyghur Autonomous Region Peoples Hospital, No 91 Tianqi Road, Urumqi, Xinjiang, 830001, China.

Background: Cervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed factors relevant to high-risk human papillomavirus (hrHPV) infection among rural Uyghur women aged > 30 years and evaluated the value of different screening methods for cervical precancerous lesions. Read More

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November 2018
3 Reads

A prospective cohort study to evaluate immunosuppressive cytokines as predictors of viral persistence and progression to pre-malignant lesion in the cervix in women infected with HR-HPV: study protocol.

BMC Infect Dis 2018 Nov 19;18(1):582. Epub 2018 Nov 19.

Chronic Infectious Diseases and Cancer Division, Center for Research on Infectious Diseases, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Morelos, Mexico.

Background: Cervical cancer (CC) is caused by a persistent infection of high-risk human papillomavirus (HR-HPV). While most HPV infections are transient, persistent HPV infections are a significant health problem in Mexico. With an estimated HPV prevalence of 10% among women in reproductive age, approximately 25% of these women present at least a positive result in triage test, which according to previous studies is expected to be confirmed as positive CIN-2/3. Read More

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November 2018
3 Reads

Does the 'equal management of equal risks' model cause overtreatment in patients with positive cervical cytology results for ASCUS/non-HPV16/18 oncogenic types?

Diagn Cytopathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Obstetrics and Gynaecology, Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.

Objectives: According to the American Society of Colposcopy and Cervical Pathology (ASCCP), cervical cytology patients who test positive for atypical squamous cells of undetermined significance (ASCUS) and the human papilloma virus (HPV) positive are recommended to undergo colposcopies. This study compared the colposcopic biopsy evaluation results of patients with positive cervical cytology results for ASCUS and HPV with regards to their HPV genotypes.

Methods: This study included 179 patients who underwent cervical cancer screening tests between June 2015 and June 2017 and whose results displayed positive cervical cervical cytology results for ASCUS and HPV. Read More

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November 2018
1 Read

Implementation of HPV-based cervical cancer screening in an organised regional screening programme: 3 years of experience.

Cytopathology 2018 Nov 12. Epub 2018 Nov 12.

Department of Gynaecology and Obstetrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Objective: The aim of this study was to evaluate the performance of human papillomavirus (HPV)-based screening in the framework of an organised cervical cancer screening programme.

Methods: A total of 46 708 women aged 35-60 years invited to the regional cervical cancer screening programme from 1 January 2012, to 31 December 2014, were enrolled. Overall, 17 770 women were screened by the Abbot RealTime hrHPV test with cytology triage and 15 605 were screened by conventional (Papanicolaou, Pap) cytology. Read More

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November 2018
8 Reads

Importance of Colposcopy Impression in the Early Diagnosis of Posthysterectomy Vaginal Cancer.

J Low Genit Tract Dis 2018 Nov 7. Epub 2018 Nov 7.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: The aim of the study was to investigate the value of cytology, high-risk human papillomavirus (hrHPV) status and colposcopy in the early diagnosis of vaginal cancer after hysterectomy.

Materials And Methods: A retrospective study was performed in the Obstetrics and Gynecology Hospital of Fudan University. Posthysterectomy patients who were diagnosed with vaginal high-grade intraepithelial lesion (HSIL) by colposcopy-directed biopsy with colposcopy impression of extensive HSIL or suspicion of cancer and underwent upper or total vaginectomy from January 2009 to December 2017 were included. Read More

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November 2018
7 Reads

Comparison of the Cervex-Brush alone to Cytobrush plus Cervex-Brush for detection of cervical dysplasia in women with a transformation zone type 3.

Cytopathology 2018 Nov 10. Epub 2018 Nov 10.

University of Bristol.

Introduction: Twenty percent of colposcopic assessments are inadequate due to a type 3 transformation zone (TZ3). In the absence of colposcopic or histological assessment, subsequent management is guided by the referral screening test. In the UK routine cervical screening is completed by a Cervex-Brush alone. Read More

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November 2018
6 Reads

Justifying conservative management of CIN2 in women younger than 25 years - A population-based study.

Gynecol Oncol 2018 Nov 6. Epub 2018 Nov 6.

Division of Gynecologic Oncology, Queen Elizabeth II Health Sciences Centre, 5820 University Avenue, Halifax, NS B3H 1Y9, Canada. Electronic address:

Objective: In 2012, the joint clinical practice guideline from the Society of Obstetricians and Gynaecologists of Canada (SOGC) changed from immediate treatment to a more conservative management of Cervical Intraepithelial Neoplasia (CIN) grade 2 in young women. In this study, the outcomes before and after this management change were reviewed in Nova Scotia, Canada.

Methods: A retrospective population-based cohort study was performed among women younger than 25 years with biopsy-proven CIN2, who were diagnosed in one of the colposcopy clinics in Nova Scotia between 2010 and 2014. Read More

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November 2018
5 Reads

Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial.

Int J Cancer 2018 Nov 9. Epub 2018 Nov 9.

Wolfson Institute of Preventive Medicine Centre for Cancer Prevention, Queen Mary University, London, UK.

Human papillomavirus (HPV)-based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. We conducted a blinded case-control study within the HPV FOCAL randomized cervical cancer screening trial of women aged 25-65 to examine whether baseline methylation testing using the S5 classifier provided triage performance similar to an algorithm relying on cytology and HPV genotyping. Groups were randomly selected from 257 women with known HPV/cytology results and pathology outcomes. Read More

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November 2018
5 Reads

Analysis of cervical human papillomavirus infection in 2300 women in Urumqi, China.

Medicine (Baltimore) 2018 Nov;97(45):e13206

Department of Obstetrics and Gynecology, Dongfang Hospital of Tongji University, Shanghai, China.

This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, and cervical biopsy were used to screen CC. Read More

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November 2018
1 Read

Perceived Susceptibility to Cervical Cancer among African American Women in the Mississippi Delta: Does Adherence to Screening Matter?

Womens Health Issues 2018 Nov 3. Epub 2018 Nov 3.

Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Background: Although preventive measures have greatly decreased the national burden of cervical cancer, racial/ethnic and geographic disparities remain, including the disproportionate incidence and mortality among African American women in the Mississippi Delta. Along with structural barriers, health perceptions and cultural beliefs influence participation in cervical screening. This study examined perceived susceptibility to cervical cancer among African American women in the Delta across three groups: 1) women attending screening appointments (screened), 2) women attending colposcopy clinic following an abnormal Papanicolaou test (colposcopy), and 3) women with no screening in 3 years or longer (unscreened/underscreened). Read More

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November 2018
8 Reads

A Colposcopy Trainer to Simulate Visualization and Biopsy of the Cervix.

Obstet Gynecol 2018 Dec;132(6):1430-1435

J. Wayne and Delores Barr Weaver Simulation Center, Mayo Clinic, Jacksonville, Florida. Corresponding author: Heidi M. Felix, DHSc, PA-C, J. Wayne and Delores Barr Weaver Simulation Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; email:

Background: Colposcopy is a common office procedure providing a magnified view of the cervix for the evaluation of an abnormal cytology result. Traditionally the procedure has been replicated in simulation training by using a sausage or hotdog to represent the cervix and allow for target biopsy. This is neither reusable nor sustainable. Read More

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December 2018
8 Reads

[Real-world research on cervical cancer screening program and effect evaluation for Chinese population].

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):764-771

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To evaluate the actual efficacy of cervical cancer and precancerous lesions screening approaches in real-world regions with different economic levels in China. The demonstrative application and effect evaluation of cervical cancer screening program were conducted in 21 hospitals nationwide from 2015 to 2018. Multi-stage sampling method was adopted to divide the country into 7 large areas according to geographical location. Read More

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October 2018
8 Reads

[Risk stratification of type-specific human papillomavirus for cervical precancers: evidence from a cross-sectional study in Shenzhen].

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):757-763

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the epidemiological genotype features of human papillomavirus (HPV) in cervical infection and their risks for cervical precancers among women in Shenzhen area. A total of 2 717 individuals ranging in age from 30~59 years were recruited in 18 community health centers of Shenzhen city from March 1 to June 15, 2015 by a cluster sampling method. The results of genotype of HPV, liquid-based cytology (LBC), colposcopy and pathology were analyzed. Read More

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October 2018
1 Read

[Performance of combined liquid based cytology and HPV nucleic acid test for detecting cervical precancer among women attending screening].

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):750-756

Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the clinical performance of HPV genotyping with cytology for detecting cervical precancer among women attending co-testing. A total of 2 883 females who participated in cervical cancer screening program were recruited from Erdos in 2016. All the participants were tested by cytology and HPV genotyping. Read More

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October 2018
3 Reads

Human papillomavirus DNA, HPV L1 capsid protein and p16 protein as markers to predict cervical lesion progression.

Arch Gynecol Obstet 2018 Nov 2. Epub 2018 Nov 2.

Department of Gynaecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201240, China.

Objectives: Cervical cancer is the most common malignant tumors in women leading to serious morbidity and mortality worldwide, especially among developing countries. A main cause of the disease is the high-risk human papillomavirus (HR-HPV) infection. HSIL usually progress to cervical cancer, and low-grade lesions, including LSIL and ASCUS, mostly turn to normal or benign lesions, but there are still a small number of patients who will progress to HSIL. Read More

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November 2018
5 Reads

Risk Factor Analysis of Persistent High-Grade Squamous Intraepithelial Lesion After Loop Electrosurgical Excision Procedure Conization.

J Low Genit Tract Dis 2018 Oct 26. Epub 2018 Oct 26.

Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Objective: The aim of the study was to analyze the clinical outcomes of high-grade squamous intraepithelial lesion (HSIL) 6 months after loop electrosurgical excision procedure (LEEP). We explored the risk factors of persistent cervical HSIL after LEEP and evaluated the methods of follow-up.

Patients And Methods: This retrospective study included women who underwent a LEEP and had a diagnosis of HSIL in their LEEP specimen during 2011 to 2015. Read More

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October 2018
2 Reads

[Clinical analysis of cervical intraepithelial lesion in postmenopausal women].

Zhonghua Fu Chan Ke Za Zhi 2018 Oct;53(10):705-710

Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310013, China.

To investigate the pathological escalation after cervical cone resection in postmenopausal women, and analyze the related influencing factors. A retrospective cohort study was conducted at the Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University between July 2013 and January 2015. Seven hundred and fifty cases of cervical cone-cut were enrolled in this study, 129 cases of them were postmenopausal women, and 621 were premenopausal women. Read More

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October 2018
1 Read

Accuracy of colposcopy-directed biopsy in detecting early cervical neoplasia: a retrospective study.

Arch Gynecol Obstet 2018 Oct 27. Epub 2018 Oct 27.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen/European Metropolitan Area Nuremberg (CCC ER-EMN), Universitätsstrasse 21-23, 91052, Erlangen, Germany.

Purpose: Colposcopy-directed biopsy is a cornerstone method for diagnosing cervical intraepithelial neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with definitive surgery.

Methods: The accuracy of colposcopy-directed biopsy was compared with the final histology in relation to different types of transformation zone (TZ), the patient's age, and the examiner's level of training. Read More

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October 2018
4 Reads

Anxiety and Depression in Thai Women with Abnormal Cervical Cytology who Attended Colposcopic Unit in Thammasat University Hospital

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2985-2989. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand. Email:

Background: Colposcopy is the standard investigation for women with abnormal cervical cytology. Waiting time to colposcopy could impact to psychological distress. Data about anxiety and depression in eastern countries patients were limited. Read More

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October 2018
6 Reads

Cervical Cancer Screening Research in the PROSPR I Consortium: Rationale, Methods, and Baseline Findings from a U.S. Cohort.

Int J Cancer 2018 Oct 24. Epub 2018 Oct 24.

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.

Little is known about the effect of evolving risk-based cervical cancer screening and management guidelines on United States (US) clinical practice and patient outcomes. We describe the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR I) consortium, methods, and baseline findings from its cervical sites: Kaiser Permanente Washington, Kaiser Permanente Northern California, Kaiser Permanente Southern California, Parkland Health & Hospital System/University of Texas Southwestern (Parkland-UTSW), and New Mexico HPV Pap Registry housed by University of New Mexico (UNM-NMHPVPR). Across these diverse healthcare settings, we collected data on human papillomavirus (HPV) vaccinations, screening tests/results, diagnostic and treatment procedures/results, and cancer diagnoses on nearly 4. Read More

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October 2018
1 Read

Is routine ECC necessary in patients with HPV16 and normal cytology?

Diagn Cytopathol 2018 Oct 24. Epub 2018 Oct 24.

Department of Gynecology and Obstetrics, Antalya Teaching and Research Hospital, Antalya, Turkey.

Background: In the present study, we primarily aimed to correlate the colposcopy results of patients with human papillomavirus (HPV) positivity and abnormal cervical screening results. Secondarily, we attempted to define the role of endocervical curettage (ECC) in the colposcopic evaluation of patients who had normal cytology and HPV16, which is the most carcinogenic HPV type.

Methods: This was a retrospective study analyzing the data of patients who had colposcopies between January 2015 and May 2016 in the Gynecological Oncology clinic of a single tertiary center. Read More

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October 2018
1 Read

Development of an in-house ELISA to detect anti-HPV16-L1 antibodies in serum and dried blood spots.

J Virol Methods 2018 Oct 20. Epub 2018 Oct 20.

Scottish HPV Reference Laboratory, NHS Lothian, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Measuring anti-HPV antibody levels is important for surveillance of the immunological response to both natural infection and vaccination. Here, an ELISA test for measurement of HPV-16L1 antibodies was developed and validated in sera and dried blood spots. An in-house ELISA was developed for measuring anti-HPV-16L1 IgA and IgG levels. Read More

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October 2018
17 Reads

The role of FH detection combined with HPV screening on the diagnostic significance of cervical cancer and precancerous lesions.

Eur Rev Med Pharmacol Sci 2018 Oct;22(19):6288-6293

Department of Obstetrics and Gynecology, The Wenzhou People's Hospital, Wenzhou, Zhejiang, China.

Objective: Cervical cancer is a common type in gynecologic malignant tumor that accounts for the leading morbidity only after breast cancer in female. This study aims to determine the diagnostic significance of uterine epithelial cells stability free body of iron protoporphyrin reduced state (FH) detection combined human papillomavirus (HPV) screening for cervical cancer.

Patients And Methods: A total of 800 patients were enrolled. Read More

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October 2018
5 Reads

The forensic rape examination: Is colposcopy really necessary?

Am J Emerg Med 2018 Oct 11. Epub 2018 Oct 11.

Department of Emergency Medicine, Spectrum Health Hospitals, Grand Rapids, MI, United States of America. Electronic address:

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October 2018
1 Read

Impact of mechanical force on posterior hymen - Implications for sexual abuse injury interpretations.

Forensic Sci Int 2018 Nov 6;292:204-211. Epub 2018 Sep 6.

Departments of Forensic Child Psychiatry and Gynecology and Obstetrics, Tampere University Hospital, Finland.

Background: Residual anogenital findings following sexual abuse are rare. There is a need for further understanding of the interpretation of hymenal findings.

Objectives: This study evaluates which is more significant with respect to posterior hymenal tissue morphology - previous consensual penile vaginal penetrations or vaginal delivery. Read More

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November 2018

Five-Year Risk of Cervical Precancer Following p16/Ki-67 Dual-Stain Triage of HPV-Positive Women.

JAMA Oncol 2018 Oct 11. Epub 2018 Oct 11.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Importance: As cervical cancer screening transitions to primary human papillomavirus (HPV) testing, effective triage and management of HPV-positive women is critical to avoid unnecessary colposcopy referral and associated harms while maintaining high sensitivity for cervical precancer. Triage with p16/Ki-67 dual-stain (DS) testing has shown high sensitivity and specificity for detection of cervical precancers; however, longitudinal studies are needed to determine the long-term risk of precancer following a negative DS result.

Objective: To evaluate the longitudinal performance of p16/Ki-67 DS triage for detection of cervical precancer in HPV-positive women over 5 years of follow-up in the context of clinical management thresholds. Read More

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October 2018
3 Reads

Integrating cervical cancer screening into safer conception services to improve women's health outcomes: a pilot study at a primary care clinic in South Africa.

Sex Transm Dis 2018 Oct 10. Epub 2018 Oct 10.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, USA and Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Sub-optimal cervical cancer screening in low- and middle-income countries contributes to preventable cervical cancer deaths, particularly amongst HIV-positive women. We assessed feasibility and outcomes of integrating cervical cancer screening into safer conception services for HIV-affected women.

Methods: At a safer conception service in Johannesburg, South Africa, HIV-affected women desiring pregnancy received a standard package of care designed to minimise HIV transmission risks, whilst optimising pre-pregnancy health. Read More

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October 2018
2 Reads

Indication of prophylactic vaccines as a tool for secondary prevention in HPV-linked disease.

Arch Gynecol Obstet 2018 Dec 10;298(6):1205-1210. Epub 2018 Oct 10.

Azienda USL-1 Massa e Carrara, Via Minzoni Don Giovanni 3, 54033, Carrara, MS, Italy.

Purpose: To determine whether quadrivalent HPV vaccination is effective in reducing recurrent disease in women with a previous history of HPV disease.

Methods: All women under 45 years of age treated for HPV-linked disease and with negative HPV test, cytology and colposcopy 3 months after treatment were enrolled. Women were randomly assigned into two groups: a group that received HPV vaccine post treatment and a group that was only submitted to follow-up. Read More

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December 2018
2 Reads

Loop Electrosurgical Excision Procedure versus Cryotherapy in the Treatment of Cervical Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Gynecol Minim Invasive Ther 2018 Oct-Dec;7(4):145-151. Epub 2018 Sep 26.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Aim: Invasive cervical cancer is proceeded by a phase of preinvasive disease that is slow to progress and can be detected, treated, and collectively referred to as cervical intraepithelial neoplasia (CIN). Several excisional and ablative treatments for CIN have been studied, with loop electrosurgical excision procedure (LEEP) and cryotherapy being the two most commonly utilized. The objective of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to compare the compare harms and benefits of LEEP versus cryotherapy in women with CIN. Read More

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September 2018
2 Reads

[Analysis of the missed diagnosis of invasive carcinoma under the microscope in HSIL diagnosed by colposcopy-guided biopsy and related influencing factors].

Zhonghua Fu Chan Ke Za Zhi 2018 Sep;53(9):613-619

Department of Gynecology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.

To observe the missed diagnosis of invasive carcinoma under the microscope (ICUM) in high grade squamous intraepithelial neoplasia (HSIL) , and analyze associated factors influencing missed ICUM. A retrospective study was performed on patients diagnosed with HSIL by colposcopy-guided biopsy and treated with loop electrosurgical excision procedure (LEEP) at the First Affiliated Hospital of Nanjing Medical University, from December 2014 to December 2016. They were non-pregnant, ≤50 years old and the cervical volume without obvious enlargement and exogenous surface without and ulcerative lesions. Read More

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September 2018
19 Reads

Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: systematic reviews and economic evaluation.

Health Technol Assess 2018 09;22(54):1-260

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Dynamic Spectral Imaging System (DySIS)map (DySIS Medical Ltd, Edinburgh, UK) and ZedScan (Zilico Limited, Manchester, UK) can be used adjunctively with conventional colposcopy, which may improve the detection of cervical intraepithelial neoplasia (CIN) and cancer.

Objectives: To systematically review the evidence on the diagnostic accuracy, clinical effectiveness and implementation of DySISmap and ZedScan as adjuncts to standard colposcopy, and to develop a cost-effectiveness model.

Methods: Four parallel systematic reviews were performed on diagnostic accuracy, clinical effectiveness issues, implementation and economic analyses. Read More

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September 2018
6 Reads

Clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay in the management of women referred to colposcopy with minor cytological abnormalities.

Diagn Cytopathol 2018 Oct 3. Epub 2018 Oct 3.

Department of Histopathology, Trinity College Dublin, Dublin, Ireland.

Background: The aim of this study was to evaluate the clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay for the detection of CIN2+ disease in women referred to colposcopy with minor cytological abnormalities.

Methods: ThinPrep liquid-based cytology samples were collected from 562 women referred to colposcopy with minor cytological abnormalities. HPV testing by both assays was performed on these samples. Read More

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October 2018
10 Reads

Prevalence characteristics of single and multiple HPV infections in women with cervical cancer and precancerous lesions in Beijing, China.

J Med Virol 2018 Oct 3. Epub 2018 Oct 3.

Department of Gynecology and Obstetrics, People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing, China.

We assessed the prevalence characteristics of single and multiple high-risk human papillomavirus (HR-HPV) infections. A total of 1783 women who underwent colposcopy and cervical biopsy for abnormal ThinPrep Cytology Test and/or HR-HPV subtype genotyping results were enrolled in the study. Among the participants, 770 were diagnosed with cervicitis, 395 with cervical intraepithelial neoplasia grade 1 (CIN1), 542 with CIN2-3, and 76 with squamous cell carcinoma (SCC), with HR-HPV infection rates of 75. Read More

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October 2018
2 Reads

Colposcopy in Evaluating Bleeding During the Second and Third Trimesters: Short-Term and Postpartum Implications.

Gynecol Obstet Invest 2018 Sep 28:1-5. Epub 2018 Sep 28.

Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel.

Background: The etiology of vaginal bleeding during pregnancy may be obstetric or non-obstetric. Though colposcopy is generally not part of the routine evaluation of 2nd- or 3rd-trimester vaginal bleeding without obvious obstetrical cause, our department does perform colposcopy and cervical cytology testing in these patients. This study assessed the need and possible contribution of colposcopy in diagnosing the etiology of 2nd- and 3rd-trimester bleeding. Read More

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September 2018
2 Reads

Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.

PLoS Med 2018 Sep 28;15(9):e1002655. Epub 2018 Sep 28.

Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.

Background: Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an elastomer scaffold that can hold up to 10 polymer-coated drug cores (or "pods"), is distinct from other IVR designs as drug release from each pod can be controlled independently. A pod-IVR has been developed for the delivery of tenofovir (TFV) disoproxil fumarate (TDF) in combination with emtricitabine (FTC), as daily oral TDF-FTC is the only Food and Drug Administration (FDA)-approved regimen for HIV PrEP. Read More

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September 2018
1 Read

Incident genital HPV infections and potential impact of HPV vaccines in adult women living with HIV/AIDS.

Hum Vaccin Immunother 2018 Sep 27:1-7. Epub 2018 Sep 27.

b Department of Biomedical Sciences for Health , University of Milan , Milan , Italy.

This study aims to describe and characterize incident HR-HPV infections and associated diseases in HIV-infected women. 805 HIV-infected women enrolled in the VALHIDATE Study were screened and followed-up for HPV by co-testing. Social, behavioral and health data were collected. Read More

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September 2018
7 Reads

DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort.

Int J Cancer 2018 Sep 27. Epub 2018 Sep 27.

Department of Gynaecologic Oncology, Cancer Research Centre Groningen, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

Objective triage strategies are required to prevent unnecessary referrals for colposcopy in population-based screening programs using primary high-risk human papillomavirus (hrHPV) testing. We have identified several DNA methylation markers with high sensitivity and specificity for detection of high-grade cervical intraepithelial neoplasia or worse (CIN2+) in women referred for colposcopy. Our study assessed diagnostic potential of these methylation markers in a hrHPV-positive screening cohort. Read More

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September 2018
1 Read

The role of random cervical biopsies in addition to colposcopy-directed biopsies in detection of CIN2.

J Obstet Gynaecol 2018 Sep 26:1-6. Epub 2018 Sep 26.

b Department of Pathology, Faculty of Medicine Vajira Hospital , Navamindradhiraj University , Bangkok , Thailand.

The aim of this study was to determine the additional values of multiple cervical biopsies when any colposcopy was performed. We developed a cross-sectional study of 92 women, who had been referred for a colposcopy because of their abnormal cervical cytology. Colposcopy-directed biopsies were taken from lesions and random non-directed biopsies were added, if their directed biopsies were fewer than four in number. Read More

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September 2018
1 Read

HPV infection and pre-neoplastic cervical lesions among 321 HIV+ women in Florence, Italy, 2006-2016: prevalence and associated factors.

New Microbiol 2018 Sep 25;41(4). Epub 2018 Sep 25.

Infectious Disease Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli (Florence), Italy.

Women living with HIV (WLWH) are at higher risk for HPV-related malignancies. To estimate the factors associated to HPV infection and to pre-neoplastic cervical lesions, we observed 321 WLWH in an HIV care-centre in Florence, Italy. In 2006-2016, WLWH followed at S. Read More

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September 2018
1 Read

Triage of Women Testing Positive With the careHPV Test on Self-Collected Vaginal Samples for Cervical Cancer Screening in a Low-Resource Setting.

J Glob Oncol 2018 Sep 29(4):1-7. Epub 2017 Sep 29.

Usha Rani Poli, MNJ Institute of Oncology & Regional Cancer Center; Swarnalata Gowrishankar and Meenakshi Swain, Apollo Hospitals, Hyderabad, India; and Jose Jeronimo, PATH, Seattle, WA.

Purpose: Human papillomavirus (HPV) DNA screening reduces cervical cancer incidence and mortality in low-resource settings. Self-collected vaginal samples tested with affordable HPV tests such as careHPV can increase the rate of screening in resource-constrained settings. We report the role of visual inspection with acetic acid (VIA) as a triage test for women testing positive with the careHPV test on self-collected vaginal samples. Read More

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September 2018
2 Reads

Racial differences in human papilloma virus types amongst United States women with HIV and cervical precancer.

AIDS 2018 Nov;32(18):2821-2826

Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.

Objective: Recent studies reported a lower human papillomavirus 16 (HPV16) prevalence in cervical precancer among African American than Caucasian women in the general population. We assessed this relationship in women with HIV.

Design: Women living with or at risk for HIV in the Women's Interagency HIV Study were followed semi-annually with Pap tests, colposcopy/histology (if indicated), and collection of cervicovaginal lavage samples for HPV testing by PCR. Read More

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November 2018
2 Reads

Cervical cancer screening using the Cervista high-risk human papillomavirus test: opportunistic screening of a hospital-based population in Fujian province, China.

Cancer Manag Res 2018 4;10:3227-3235. Epub 2018 Sep 4.

Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China,

Objectives: The Cervista high-risk human papillomavirus (HR-HPV) test was evaluated as a primary screening method for cervical cancer in women aged ≥21 years and was compared with different screening and triage combinations.

Materials And Methods: A nested case-control study within the Fujian provincial Cervical Lesion Screening Cohorts was used to evaluate the Cervista test as the primary cervical screening method in a hospital-based population. Strategy 1 primarily screened using a cytology screen with HR-HPV testing used for triage. Read More

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September 2018
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Sexually Transmitted Infections Detected by Multiplex Real Time PCR in Asymptomatic Women and Association with Cervical Intraepithelial Neoplasia.

Rev Bras Ginecol Obstet 2018 Sep 19;40(9):540-546. Epub 2018 Sep 19.

Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective:  To determine the frequency of sexually transmitted infections (STIs) in asymptomatic women and the association of STIs with cervical intraepithelial neoplasia (CIN).

Methods:  A cross-sectional study was performed, enrolling women examined in a general gynecology clinic and in a colposcopy referral center from October 2014 to October 2015. The colposcopy group consisted of 71 women, and the general gynecology group consisted of 55 women. Read More

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September 2018
4 Reads

The use of colposcopic punch biopsy in the management of abnormal cervical cytology: a 5-year retrospective audit.

J Obstet Gynaecol 2018 Sep 19:1-5. Epub 2018 Sep 19.

a Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine , Istanbul University , Istanbul , Turkey.

The aim of this study was to determine the accuracy of colposcopic punch biopsy to detect cervical epithelial neoplasia (CIN) II + in patients with abnormal cervical cytology and the major colposcopic findings in patients who underwent a loop electrosurgical excision procedure (LEEP), subsequently. A total of 231 patients with abnormal cervical cytology who underwent a colposcopy guided cervical biopsy and subsequent LEEP were analysed. The mean age was 33. Read More

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September 2018
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0.600 Impact Factor

Risk stratification of cervical disease using detection of human papillomavirus (HPV) E4 protein and cellular MCM protein in clinical liquid based cytology samples.

J Clin Virol 2018 Nov 31;108:19-25. Epub 2018 Aug 31.

MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK. Electronic address:

Background: While human papillomavirus (HPV) DNA testing offers high sensitivity for the detection of significant cervical disease, its specificity is suboptimal given the high prevalence of transient HPV infections (CIN1 or less). Biomarkers to identify those suffering from low grade disease from those with high grade disease could save healthcare costs and reduce patient anxiety.

Objective: The objective of the present work was to develop and test an immunohistochemistry (IHC)-based dual viral and cellular biomarker strategy which was applicable to liquid based cytology (LBC) samples. Read More

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November 2018
5 Reads

Randomised trial of HPV self-sampling among non-attenders in the Slovenian cervical screening programme ZORA: comparing three different screening approaches.

Radiol Oncol 2018 Sep 14;52(4):399-412. Epub 2018 Sep 14.

National Cervical Cancer Screening Programme and Registry ZORA, Epidemiology and Cancer Registry, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Background To overcome obstacles within the Slovenian organised cervical cancer screening programme, a randomised pilot study of human papillomavirus (HPV) self-sampling among non-attenders was performed, aiming to assess three different screening approaches. Participants and methods Non-attenders aged 30-64 years from two Slovenian regions were randomised to two HPV self-sampling groups-the opt-in (I1, n = 14.400) and the opt-out (I2, n = 9. Read More

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September 2018
2 Reads