9,601 results match your criteria Colposcopy


The p16/ki-67 assay is a safe, effective and rapid approach to triage women with mild cervical lesions.

PLoS One 2021 11;16(6):e0253045. Epub 2021 Jun 11.

1st Department of Obstetrics and Gynecology, "Alexandra" Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: The aim of this study was to evaluate the diagnostic accuracy and efficiency of p16/ki-67 dual stain in the identification of CIN2+ lesions, in Greek women with ASCUS or LSIL cytology.

Methods: A total of 200 women, 20 to 60 years old, were enrolled in the study. All samples were cytologically evaluated and performed for p16/ki-67 and high-risk HPV (HR-HPV) test. Read More

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Rescreening of high-risk HPV positive Papanicolaou tests initially screened as negative is a low yield procedure in the era of HPV genotyping.

J Am Soc Cytopathol 2021 May 19. Epub 2021 May 19.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Electronic address:

Introduction: Many laboratories rescreen Papanicolaou test slides initially interpreted as negative, but positive for human papillomavirus (HPV) high-risk types, as a quality control measure. We have evaluated the utility of this practice in the era of HPV genotyping as a laboratory improvement project.

Material And Methods: Between August 2016 and October 2019, we identified 3618 rescreened Papanicolaou tests with follow-up biopsies. Read More

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Use of extended HR-HPV Genotyping in improving the Triage Strategy of 2019 ASCCP recommendations in Women with positive HR-HPV diagnosis and Simultaneous LSIL Cytology Results.

J Cancer 2021 19;12(14):4332-4340. Epub 2021 May 19.

Department of Gynecology, Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian, P.R. China.

According to the 2019 American Society for Colposcopy and Cervical Pathology (ASCCP) recommendations, women with a positive high-risk human papillomavirus (HR-HPV) diagnosis and low-grade cervical intraepithelial lesion (LSIL) cytology result should be referred for further colposcopy examination. However, this strategy results in over-treatment in several cases. In this study, we assessed the performance of extended HR-HPV genotyping in women with a simultaneous positive HR-HPV and LSIL diagnosis with the aim of improving the current triage strategy. Read More

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The impact of the CervicalCheck controversy on provision of colposcopy services in Ireland: A cohort study.

Eur J Obstet Gynecol Reprod Biol 2021 May 24;262:228-231. Epub 2021 May 24.

Department of Colposcopy, The National Maternity Hospital, Dublin, Ireland.

Objectives: In 2018, an inquiry into the Irish Cervical Cancer screening programme (CervicalCheck) was initiated, following publicised cases of non-disclosure regarding internal audit results of cytology screening in women diagnosed with cervical cancer. The inquiry attracted widespread media coverage and the government offered women free, out of programme screening. We investigated whether the controversy led to an increase in referrals based on clinical suspicion and the impact on waiting times for abnormal cytology. Read More

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Evaluation of p16 immunocytology and human papillomavirus (HPV) genotyping triage after primary HPV cervical cancer screening on self-samples in China.

Gynecol Oncol 2021 May 28. Epub 2021 May 28.

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, PR China; Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, PR China; Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases, Shenzhen 518036, PR China. Electronic address:

Objective: Self-sampling for human papillomavirus (HPV) testing is an effective option to increase the cervical screening coverage. How to best triage HPV-positive self-samples remains controversial. Here, we evaluated the performance of a novel p16 immunocytology approach (p16) and HPV genotyping in triaging HPV-positive self-samples. Read More

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Self-collected versus clinician-collected cervical samples for the detection of HPV infections by 14-type DNA and 7-type mRNA tests.

BMC Infect Dis 2021 May 31;21(1):504. Epub 2021 May 31.

Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway.

Background: HPV self-sampling has been widely supported by the scientific community following a strong body of literature on the subject. Self-sampling is important in cervical cancer screening as it has been shown to improve participation. It is well documented that HPV-testing has proven superior to cytology with regards to sensitivity in detection of CIN and cancer. Read More

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The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.

Microbiome 2021 May 28;9(1):124. Epub 2021 May 28.

IRDB, Department of Metabolism, Digestion and Reproduction - Surgery and Cancer, Hammersmith Campus, Imperial College London, W12 0NN, London, UK.

Background: Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammation and bariatric surgery.

Methods: Vaginal bacterial composition assessed by high-throughput sequencing of bacterial 16S rRNA genes and local cytokine levels measured using a multiplexed Magnetic Luminex Screening Assay were compared between 67 obese and 42 non-obese women. Read More

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The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts.

Prev Med 2021 May 25;150:106641. Epub 2021 May 25.

Division of Gynecologic Oncology, University of Toronto, Toronto, Canada; Cancer Care Ontario, Toronto, Canada; Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada.

Assess Ontario's school-based human papillomavirus (HPV) vaccination program on reducing rates of cervical dysplasia, colposcopy services and treatment for genital warts, cervical conization, cryotherapy and laser vaporization of the lower genital tract. Women born in 1995 in Ontario, Canada were the first cohort of students to receive the vaccine. We followed these women from age 18-23 and identified pap test cytology results, referral and attendance at colposcopy, treatment of HPV related warts and treatment of lower-genital tract dysplasia using administrative databases. Read More

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Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research.

J Med Internet Res 2021 May 27;23(5):e23350. Epub 2021 May 27.

Duke Global Health Institute, Durham, NC, United States.

Background: Nearly 90% of deaths due to cervical cancer occur in low- and middle-income countries (LMICs). In recent years, many digital health strategies have been implemented in LMICs to ameliorate patient-, provider-, and health system-level challenges in cervical cancer control. However, there are limited efforts to systematically review the effectiveness and current landscape of digital health strategies for cervical cancer control in LMICs. Read More

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Applying Artificial Intelligence to Gynecologic Oncology: A Review.

Obstet Gynecol Surv 2021 May;76(5):292-301

Director of Gynecologic Oncology, Palo Alto Medical Foundation Research Institute, Palo Alto, CA.

Importance: Artificial intelligence (AI) will play an increasing role in health care. In gynecologic oncology, it can advance tailored screening, precision surgery, and personalized targeted therapies.

Objective: The aim of this study was to review the role of AI in gynecologic oncology. Read More

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Cervical pap smears and pandemics: The effect of COVID-19 on screening uptake & opportunities to improve.

Authors:
Hannah Masson

Womens Health (Lond) 2021 Jan-Dec;17:17455065211017070

School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.

Background: The Coronavirus disease 2019 (COVID-19) pandemic has led to an unprecedented upheaval within global healthcare systems and resulted in the temporary pausing of the National Health Service (NHS) Scotland Cervical Screening Programme. With several months of backlogs in appointments, there has not only been a reduction in primary samples being taken for human papilloma virus (HPV) testing but there have also been fewer women referred to colposcopy for investigation and treatment of precancerous or cancerous changes as a result. Encouraging uptake for cervical screening was always a priority before the pandemic, but it is even more important now, considering that the fears and barriers to screening that women may have are now exacerbated by COVID-19. Read More

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Impact of disruptions and recovery for established cervical screening programs across a range of high-income country program designs, using COVID-19 as an example: A modelled analysis.

Prev Med 2021 May 21:106623. Epub 2021 May 21.

Cancer Research Division, Cancer Council NSW, Sydney, Australia; School of Public Health, University of Sydney, Sydney, Australia. Electronic address:

COVID-19 has disrupted cervical screening in several countries, due to a range of policy-, health-service and participant-related factors. Using three well-established models of cervical cancer natural history adapted to simulate screening across four countries, we compared the impact of a range of standardised screening disruption scenarios in four countries that vary in their cervical cancer prevention programs. All scenarios assumed a 6- or 12-month disruption followed by a rapid catch-up of missed screens. Read More

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Association of lesion area measured by colposcopy and cervical neoplasia.

J Obstet Gynaecol 2021 May 24:1-4. Epub 2021 May 24.

Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba - MG, Brazil.

Studies have demonstrated that the size of lesion in colposcopic imaging can be associated with the grade of CIN. We evaluated 36 patients and at the time of colposcopy, the images were recorded and analysed for lesion area measurement. A ROC curve was used to obtain the area under the curve and to determine the best cut-off values between area lesion (pixels) and biopsy result. Read More

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Comparison of the clinical and analytical performance of Alinity m HR HPV and cobas 4800 HPV assays in a population-based screening setting.

J Clin Virol 2021 Jul 10;140:104851. Epub 2021 May 10.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška cesta 4, 1000 Ljubljana, Slovenia. Electronic address:

Background: The recently launched Abbott Alinity m HR HPV (Alinity) assay separately identifies high-risk human papillomavirus (hrHPV) genotypes HPV16, HPV18, and HPV45, and reports 11 other genotypes as two aggregates.

Methods: Clinical and analytical performance of Alinity was compared with the cobas 4800 HPV assay on 4,334 women aged 20-64 years attending routine, population-based organized cervical cancer screening during 2009/2010. After 36 months, they were invited to participate in the second screening round (2012-2014) and later followed-up through centralized national cervical cancer screening registry. Read More

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[The Clinical Significance of HPV L1/PD-L1 Tests Combined with Colposcopy for Cervical Precancerous Lesions and Cervical Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 May;52(3):516-522

Department of Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the expression of human papilloma virus (HPV) L1 protein and programmed cell death ligand-1 (PD-L1) protein in cervical precancerous lesions and cervical cancer, to analyze the correlation between HPV L1 and PD-L1 expression tests combined with colposcopy and the occurrence and development of of cervical lesions, and to determine the significance of the combined examination for auxiliary differential diagnosis.

Methods: 260 patients with high-risk HPV (HR-HPV) infection who were treated at West China Second University Hospital, Sichuan University from January, 2018 to January, 2020 were included in the study. 260 cervical cytology specimens were collected, of which 218 cervical histology specimens were collected, of which 202 cases underwent colposcopy. Read More

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Feasibility and Acceptability of Smartphone-Based Cervical Cancer Screening Among HIV-Positive Women in Western Kenya.

JCO Glob Oncol 2021 May;7:686-693

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA.

Purpose: Adjunct cervical cancer screening methods are under evaluation to improve the diagnostic accuracy of human papillomavirus (HPV)-based screening in low- and middle-income countries. We evaluated the feasibility and acceptability of smartphone-based cervicography among HPV-positive women living with HIV (WLWH) in Western Kenya.

Methods: HPV-positive WLWH of 25-49 years of age enrolled in a clinical trial (ClinicalTrials. Read More

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Diagnosis of Cervical Cancer based on Ensemble Deep Learning Network using Colposcopy Images.

Biomed Res Int 2021 4;2021:5584004. Epub 2021 May 4.

Department of Computer Science, School of Informatics and Electrical Engineering, Institute of Technology, Ambo University, Ambo, Post Box No. 19, Ethiopia.

Traditional screening of cervical cancer type classification majorly depends on the pathologist's experience, which also has less accuracy. Colposcopy is a critical component of cervical cancer prevention. In conjunction with precancer screening and treatment, colposcopy has played an essential role in lowering the incidence and mortality from cervical cancer over the last 50 years. Read More

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Effect of introducing human papillomavirus genotyping into real-world screening on cervical cancer screening in China: a retrospective population-based cohort study.

Ther Adv Med Oncol 2021 28;13:17588359211010939. Epub 2021 Apr 28.

Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian 350001, P.R. China.

Background: China's Fujian Cervical Pilot Project (FCPP) transitioned cervical cancer screening from high-risk human papillomavirus (HR-HPV) nongenotyping to genotyping. We investigated the clinical impact of this introduction, comparing performance indicators between HR-HPV genotyping combined with cytology screening (HR-HPV genotyping period) and the previous HR-HPV nongenotyping combined with cytology screening (HR-HPV nongenotyping period).

Methods: A retrospective population-based cohort study was performed using data from the FCPP for China. Read More

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Implementing HPV Testing for Colposcopy Patients in a Regional Centre.

J Obstet Gynaecol Can 2021 05;43(5):555-556

Department of Pathology and Laboratory Medicine, Western University, London, ON; Obstetrics and Gynecology, Schulich School of Medicine & Dentistry, Western University, London, ON. Electronic address:

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The impact of the COVID-19 pandemic on the Ontario Cervical Screening Program, colposcopy and treatment services in Ontario, Canada: a population-based study.

BJOG 2021 May 13. Epub 2021 May 13.

Ontario Health (Cancer Care Ontario), Toronto, ON, Canada.

Objective: To describe the immediate impact of the COVID-19 pandemic on cervical screening, colposcopy and treatment volumes in Ontario, Canada.

Design: Population-based retrospective observational study.

Setting: Ontario, Canada. Read More

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Ordinal losses for classification of cervical cancer risk.

PeerJ Comput Sci 2021 23;7:e457. Epub 2021 Apr 23.

Institute for Systems and Computer Engineering, Technology and Science, Porto, Portugal.

Cervical cancer is the fourth leading cause of cancer-related deaths in women, especially in low to middle-income countries. Despite the outburst of recent scientific advances, there is no totally effective treatment, especially when diagnosed in an advanced stage. Screening tests, such as cytology or colposcopy, have been responsible for a substantial decrease in cervical cancer deaths. Read More

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The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):506-519. Epub 2021 Mar 22.

Center for Innovative Medical Technologies "European Clinic", Moscow, Russian Federation.

Cervical cancer is an important problem in women's health and a worldwide oncological disease. In 2018, the WHO registered 569,847 new cases in the world, and 3.4% were in the Russian Federation. Read More

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Visual inspection with acetic acid (VIA) positivity among female sex workers: a cross-sectional study highlighting one-year experiences in early detection of pre-cancerous and cancerous cervical lesions in Kampala, Uganda.

Infect Agent Cancer 2021 May 11;16(1):31. Epub 2021 May 11.

MRC/UVRI and LSHTM Uganda Research Unit, P.O Box 49, Entebbe, Uganda.

Background: Although cervical cancer is preventable, most women in sub-Saharan Africa (SSA) do not receive routine screening and few treatment options exist. Female Sex Workers (FSWs) are among the Ugandan female population at highest risk of acquiring sexually transmitted infections (STIs) including HIV and human papilloma viruses (HPV), the cause of cervical cancer. We report one-year experiences of visual inspection with acetic acid (VIA) positivity among FSWs in the early detection of pre-cancerous and cancerous cervical lesions in Kampala, Uganda. Read More

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The effectiveness of cold-knife conization (CKC) for post-menopausal women with cervical high-grade squamous intraepithelial lesion: a retrospective study.

BMC Surg 2021 May 12;21(1):241. Epub 2021 May 12.

Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Key Laboratory of Human Development and Reproductive Regulation, 156 Nankai Third Road, Nankai, Tianjin, 300100, People's Republic of China.

Background: The effectiveness of surgery of high-grade squamous intraepithelial lesion in post-menopausal women needs to be investigated. This study evaluated the clinical significance of cold-knife conization in the diagnosis and surgery of cervical high-grade squamous intraepithelial lesions in post-menopausal women.

Methods: We conducted a retrospective analysis of post- and pre-menopausal patients with high-grade squamous intraepithelial lesion. Read More

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Application of artificial intelligence in gynecologic malignancies: A review.

J Obstet Gynaecol Res 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

With the development of machine learning and deep learning models, artificial intelligence is now being applied to the field of medicine. In oncology, the use of artificial intelligence for the diagnostic evaluation of medical images such as radiographic images, omics analysis using genome data, and clinical information has been increasing in recent years. There have been increasing numbers of reports on the use of artificial intelligence in the field of gynecologic malignancies, and we introduce and review these studies. Read More

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Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study.

PLoS Med 2021 May 10;18(5):e1003641. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk of preterm delivery (PTD) although the exact pathomechanism is not yet understood. Women with untreated CIN also seem to have an increased risk of PTD. It is unclear whether this is attributable to human papillomavirus (HPV) infection or other factors. Read More

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Primary HPV cervical screening: Clinical audit of outcomes of women seen at a tertiary referral centre for colposcopy in Australia.

Aust N Z J Obstet Gynaecol 2021 May 7. Epub 2021 May 7.

Department of Oncology & Dysplasia, The Royal Women's Hospital, Melbourne, Victoria, Australia.

Background: Primary human papillomavirus (HPV) screening was introduced in Australia in December 2017.

Aims: Outcomes for women after positive HPV in their cervical screening test (CST).

Materials And Methods: A retrospective observational study of 4458 women seen at the Royal Women's Hospital Colposcopy Clinic from 1 January 2018 to 31 July 2020. Read More

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Electronic Health Record Transition and Impact on Screening Test Follow-Up.

Jt Comm J Qual Patient Saf 2021 Mar 31. Epub 2021 Mar 31.

Introduction: Nonurgent clinically significant test results (CSTRs) are a common cause of missed and delayed diagnoses. However, little is known about the impact of electronic health record (EHR) transitions on CSTR follow-up. This study examines follow-up rates for three CSTRs (incidental lung nodules [IPNs]), prostate-specific antigen [PSA], and Pap smears) before and after EHR transition. Read More

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