8,904 results match your criteria Colposcopy


Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients.

Front Oncol 2019 3;9:213. Epub 2019 Apr 3.

Human Histology and Embryology Unit, University of Verona Medical School, Verona, Italy.

High oncogenic risk human papillomaviruses (HR-HPVs) promote cervical carcinoma development, the fourth most common feminine cancer. A slow oncodevelopmental phase-defined histopathologically as Cervical Intraepithelial Neoplasia (CIN) grades 1-3, or cytologically as Low- or High-grade Squamous Intraepithelial Lesions (LSIL or HSIL)-precedes the malignancy. Cervical carcinoma screenings through HR-HPV genotyping and Pap smears are regularly performed in Western countries. Read More

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http://dx.doi.org/10.3389/fonc.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456695PMC

Performance of Different Combination Models of High-Risk HPV Genotyping in Triaging Chinese Women With Atypical Squamous Cells of Undetermined Significance.

Front Oncol 2019 3;9:202. Epub 2019 Apr 3.

Department of Cancer Epidemiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

The purpose of this study was to evaluate the effect of different combination models of high-risk human papilloma viruses (HPV) genotyping in triaging Chinese women with atypical squamous cells of undetermined significance (ASCUS). We established a screening cohort of 3,997 Chinese women who underwent cervical cytology and HPV genotyping test. Women with ASCUS cytology underwent punch biopsy under colposcopy/endocervical curettage. Read More

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http://dx.doi.org/10.3389/fonc.2019.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456653PMC

Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany.

Br J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.

Background: Randomised controlled trials showed human papillomavirus (HPV)-based screening leads to a significant reduction in cervical cancer incidence compared with cytology-based screening only.

Methods: Non-hysterectomised participants ≥30 years underwent co-testing with Papanicolaou (Pap) smear and HR-HPV testing (Hybrid Capture 2; HC2). Women with normal findings had their next screening round after 5 years, and HC2+ and Pap abnormal cases were immediately referred for colposcopy, while cases with discordant findings had repeat testing after 12 months with referral to colposcopy in cases with persistent positive findings. Read More

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http://www.nature.com/articles/s41416-019-0453-2
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http://dx.doi.org/10.1038/s41416-019-0453-2DOI Listing
April 2019
2 Reads

Estimating the human papillomavirus genotype attribution in screen-detected high-grade cervical lesions.

Epidemiology 2019 Apr 8. Epub 2019 Apr 8.

Background: Genotype attribution in high-grade cervical lesions (CIN3+) can be calculated by the hierarchical or proportional method, but these do not account for the genotype distribution in the general population and cannot assess the number of genotype-specific high-grade cervical lesions (CIN3+).

Methods: We present a statistical method for estimating genotype-specific CIN3+ risks and genotype attribution in CIN3+ from cervical screening samples. A key assumption is that genotype-specific infections in women with multiple infections have independent progression risks. Read More

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http://dx.doi.org/10.1097/EDE.0000000000001026DOI Listing

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology.

J Obstet Gynaecol Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Aim: In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on-going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women's health education program that leads into cervical cancer prevention by establishment of a system for early detection and treatment. It begins by health education, screening for human papillomavirus (HPV), followed by colposcopy and quicker treatment of earlier precursor lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.13968
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http://dx.doi.org/10.1111/jog.13968DOI Listing
April 2019
2 Reads

Tablet-Based Patient Education Regarding Human Papillomavirus Vaccination in Colposcopy Clinic.

J Low Genit Tract Dis 2019 Apr 8. Epub 2019 Apr 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.

Objective: The aim of this study was to use an electronic tablet-based education module to increase patient knowledge about human papillomavirus (HPV).

Methods: Patients presenting to an academic colposcopy clinic were first queried as to whether they had been infected with HPV. A quality improvement project was then conducted using a 4-question pretest assessing baseline knowledge about HPV and cancer, followed by a tablet-based education module and a 5-question posttest. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000474DOI Listing
April 2019
4 Reads

[Diagnostic criterion for uterine cervical carcinoma and precancerous lesions].

Authors:

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):265-269

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.001DOI Listing
April 2019
1 Read

Clinical outcome of high-grade cervical intraepithelial neoplasia during pregnancy: A 10-year experience.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 25;236:173-176. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: To investigate the clinical outcome of high-grade cervical intraepithelial neoplasia (CIN) diagnosed by colposcopy-directed biopsy during pregnancy and to evaluate the risk factors for persistent disease.

Study Design: This retrospective study included pregnant women who were diagnosed with CIN2+ by colposcopy-directed biopsy from January 2005 to December 2014. The clinical characteristics, histopathologic results, and human papillomavirus (HPV) test results were reviewed. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.023DOI Listing
March 2019
2 Reads
1.627 Impact Factor

The impact of decentralising colposcopy services from tertiary-level to primary-level care in inner-city Johannesburg, South Africa: a before and after study.

BMJ Open 2019 Mar 30;9(3):e024726. Epub 2019 Mar 30.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.

Objective: To assess whether decentralising colposcopy services to a primary care facility in inner-city Johannesburg, South Africa raises access to colposcopy.

Design: Before-after study comparing 2 years before and 2 years after decentralisation, using clinical records and laboratory data on cervical cytology and histology.

Primary Outcome: The proportion of all women attending Hillbrow Community Health Centre (HCHC) with an abnormal Papanikolaou (Pap) smear who had a colposcopy post-decentralisation. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024726DOI Listing
March 2019
7 Reads

Diagnosing Premalignant Lesions of Uterine Cervix in A ResourceConstraint Setting: A Narrative Review.

West Afr J Med 2019 Jan-Apr;36(1):48-53

Family Medicine Department, Aminu Kano Teaching Hospital, Kano Nigeria.

Cervical cancer is an important public health problem whose prevention should be integrated in all existing primary health care and women's health programmes in Nigeria and other developing countries. Cervical cancer is the second most common female malignancy in the world and it is the leading cause of cancer related deaths among women in developing countries. Furthermore, developing countries account for 80% of global deaths from cervical cancer. Read More

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March 2019
1 Read

Management of ASC-US/HPV positive post-menopausal woman.

Virol J 2019 03 28;16(1):39. Epub 2019 Mar 28.

Department of General Surgery and Medical Surgery Specialities, Gynecological Clinic of the University of Catania, Policlinico, Via S. Sofia, 78, Catania, Italy.

Background: The aim of our study was to determine which diagnostic course is best to identify women at risk of CIN2+ among post-menopausal women with cytological diagnosis of ASCUS METHODS: We selected women who had been post-menopausal for at least one year , and who had completed the entire diagnostic-therapeutic course that they had undertaken. The sample was divided into two arms: in the first arm, we considered 146 ASCUS positive women who had undergone the HPV test, colposcopy and then underwent more detailed diagnostics by means of LEEP or a scraping of the cervical canal. The second arm was made up of 124 ASCUS positive women who had undergone a vaginal administration of estriolo, the HPV test and colposcopy. Read More

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http://dx.doi.org/10.1186/s12985-019-1145-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437871PMC
March 2019
2 Reads

Avaliação do serviço de coleta para exame colpocitológico pela escala SERVQUAL.

Rev Bras Enferm 2019 Jan-Feb;72(1):118-124

Universidade do Estado do Pará, Magalhães Barata. School of Nursing. Belém, Pará, Brazil.

Objective: To analyze women's perception of the quality of the service provided for colposcopy test in the city of Belém (PA), Brazil.

Method: Quantitative-descriptive study on 400 women who underwent Pap test on the public healthcare network, using the Service Quality (SERVQUAL) model. We used the Cronbach's alpha index to measure the reliability of the scale, and data were analyzed by quartiles of the gaps of the dimensions: tangibility, responsiveness, reliability, assurance, and empathy. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0331DOI Listing
May 2018
1 Read

Predictors of Absent High-grade Cervical Intraepithelial Neoplasia (CIN) in Loop Electrosurgical Excision Procedure Specimens of Patients with Colposcopic Directed Biopsy-Confirmed High-Grade CIN

Asian Pac J Cancer Prev 2019 Mar 26;20(3):849-854. Epub 2019 Mar 26.

Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand. Email:

Objective: To determine predictors of having cervical intraepithelial neoplasia (CIN) 1 or less in loop electrosurgical excision procedure (LEEP) specimens of patients with colposcopic directed biopsy-confirmed CIN 2-3. Methods: Two hundred and eighty patients with colposcopic directed biopsy-confirmed CIN 2-3 who subsequently underwent LEEP were enrolled in the retrospective study. Related clinical data were collected to determine the predictors of CIN 1 or less in LEEP specimens. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.3.849DOI Listing
March 2019
2 Reads

Histopathology of Women with “Atypical Squamous Cells Cannot Exclude High-Grade Squamous Intraepithelial Lesion” (ASC-H) Smears

Asian Pac J Cancer Prev 2019 Mar 26;20(3):683-686. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objectives: To evaluate prevalence of underlying significant pathologies among women with cervical smears rated as ‘atypical squamous cells cannot exclude high grade squamous intraepithelial lesion (ASC-H)’, as well as associated risk factors. Methods: Medical records were reviewed of all consecutive women with ASC-H smears who had undergone colposcopy at Srinagarind Hospital from January 2008 to July 2016. Significant pathology results included cervical intraepithelial neoplasia (CIN) 2-3, adenocarcinoma in situ (AIS), endometrial hyperplasia, and cancer of any original site. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.3.683DOI Listing
March 2019
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BAYESIAN ANALYSIS OF BASELINE RISK OF CIN2 AND ≥CIN3 BY HPV GENOTYPE IN A EUROPEAN REFERRAL COHORT.

Int J Cancer 2019 Mar 20. Epub 2019 Mar 20.

Laboratorio Analisi Cliniche, Humanitas Research Hospital, Milan, Italy.

Whereas HPV16 and HVP18 has been the focus in current risk-based cervical cancer screening algorithms using HPV genotype information, mounting evidence suggests that oncogenic HPV types such as HPV 31, 33, 52 and 58 pose a ≥CIN3 risk equivalent or greater than that of HPV 18, and the combined risk of HPV 31 and HPV33 rivals even HPV16 in women above 30 years of age. Here, we evaluate the baseline risk of CIN2 and CIN3 by genotype in a colposcopy referral population from Denmark and Italy. In total, 655 women were enrolled upon a referral to colposcopy following a positive screening sample. Read More

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http://dx.doi.org/10.1002/ijc.32291DOI Listing
March 2019
2 Reads

Self-Collection and Molecular Diagnosis for Detection of Human Papillomavirus: Why Incorporate It?

Curr Infect Dis Rep 2019 Mar 19;21(4):13. Epub 2019 Mar 19.

Bioscience Institute from Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

Purpose Of Review: Cervical cancer, the third cause of death by cancer among Brazil's women, is associated with human papillomavirus (HPV) infection. In some countries of South America, North America, Europe, and Oceania, initial screening for HPV DNA and subsequent follow-up with HPV-positive patients using colposcopy and cytological testing are used as preventative measures.

Recent Findings: For HPV DNA detection, it is necessary to obtain cervical cells by conventional clinical collection method or self-collection of the cells that flake off from the uterine cervix and vaginal canal. Read More

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http://dx.doi.org/10.1007/s11908-019-0674-9DOI Listing
March 2019
2 Reads

PCR-reverse dot blot human papillomavirus genotyping as a primary screening test for cervical cancer in a hospital-based cohort.

J Gynecol Oncol 2019 May;30(3):e29

Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: To evaluate the polymerase chain reaction (PCR)-reverse-dot-blot (RDB) human papillomavirus (HPV) genotyping test as a feasible assay for the cervical cancer primary screening.

Methods: In a hospital-based cohort, a total of 21,568 women were voluntarily enrolled from March 2009 to November 2016 for evaluating the 3 current cervical cancer screening strategies: co-test, cytology primary and high-risk HPV (HR-HPV) primary by using PCR-RDB HPV genotyping and liquid-based cytology (thinprep cytologic test [TCT]). Women with HR-HPV infection and/or abnormal cytology were referred for colposcopy, and the biopsy or conization was performed according to the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424850PMC
May 2019
2 Reads

The combined impact of implementing HPV immunisation and primary HPV screening in New Zealand: Transitional and long-term benefits, costs and resource utilisation implications.

Gynecol Oncol 2019 03;152(3):472-479

Cancer Research Division, Cancer Council NSW, Sydney, Australia; School of Public Health, University of Sydney, Sydney, Australia. Electronic address:

Background: In response to emergent evidence, many countries are transitioning from cytology-based to HPV screening. We evaluated the impact of an upcoming transition on health outcomes and resource utilisation in New Zealand.

Methods: An extensively validated model of HPV transmission, vaccination, natural history and cervical screening ('Policy1-Cervix') was utilised to simulate a transition from three-yearly cytology for women 20-69 years to five-yearly HPV screening with 16/18 genotyping for women 25-69 years, accounting for population growth and the impact of HPV immunisation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183136
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http://dx.doi.org/10.1016/j.ygyno.2018.10.045DOI Listing
March 2019
2 Reads

Clinical Performance of SurePath™ Preservative Compared to PreservCyt® with Cobas® and Hybrid Capture® 2 HPV Tests in a Colposcopy Population.

Clin Lab 2019 Mar;65(3)

Background: Until recently, no HPV test had been US FDA-approved for SurePath preservative. Clinical performance remains incompletely understood. The clinical performances of the Cobas HPV Test (Cobas) and Hybrid Capture 2 High-Risk HPV DNA Test (HC2) with PreservCyt and SurePath preservatives were compared. Read More

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http://www.clin-lab-publications.com/article/2945
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http://dx.doi.org/10.7754/Clin.Lab.2018.180734DOI Listing
March 2019
2 Reads

Progress in immunocytochemical staining for cervical cancer screening.

Cancer Manag Res 2019 22;11:1817-1827. Epub 2019 Feb 22.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Cervical cancer is one of the most common gynecological malignancies. In recent years, the implementation of cervical cancer screening has resulted in the effective control of cervical cancer incidence. However, many deficiencies still exist in the current screening techniques and strategies. Read More

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http://dx.doi.org/10.2147/CMAR.S195349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391129PMC
February 2019
1 Read

HPV infections and cytologic abnormalities in vaccinated women 21-34 years of age: Results from the baseline phase of the Onclarity trial.

Gynecol Oncol 2019 Mar 7. Epub 2019 Mar 7.

Becton, Dickinson and Company, BD Life Sciences - Diagnostic Systems, 7 Loveton Circle, Sparks, MD 21152, USA.

Objectives: Countries with school-based human papillomavirus (HPV) vaccination have seen significant reductions in vaccine-targeted HPV infections, cytologic abnormalities, and high-grade cervical intraepithelial neoplasia (≥CIN2). However, the impact of HPV vaccination in the United States (where vaccination is largely opportunistic) may be less due to lower coverage rates and vaccination in patients at ages beyond the recommended routine vaccination age.

Methods: The Onclarity trial enrolled 33,858 subjects ≥21 years who were screened with cytology and the BD Onclarity HPV Assay. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193012
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http://dx.doi.org/10.1016/j.ygyno.2019.02.016DOI Listing
March 2019
4 Reads

Antinuclear antibodies in patients with cervical lesions and invasive cervical cancer.

Immunol Lett 2019 Apr 5;208:8-10. Epub 2019 Mar 5.

Evangelical Mackenzie University, Medicine Department, Curitiba, Brazil; Immunopathology Laboratory, Clinical Hospital, Federal University of Paraná, Curitiba,Brazil; Positivo University, Medicine Department, Curitiba, Brazil. Electronic address:

Background: Antinuclear antibodies (ANA) have been found in several types of cancer although the meaning of its presence is not completely known.

Aim: To study the prevalence of ANA in patients with cervical intraepithelial lesion and invasive cervical cancer.

Methods: A total of 205 women who underwent screening for cervical cancer or treatment at the Erasto Gaertner Cancer Hospital in Curitiba - Brazil, were enrolled in the study. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.002DOI Listing
April 2019
2 Reads

Shift Work Patterns, Chronotype, and Epithelial Ovarian Cancer Risk.

Cancer Epidemiol Biomarkers Prev 2019 Mar 6. Epub 2019 Mar 6.

Université de Montréal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.

Shift work causing circadian disruption is classified as a "probable carcinogen" and may contribute to the pathogenesis of hormone-sensitive cancers. This study investigated shift work exposure in relation to epithelial ovarian cancer (EOC) risk. In a population-based case-control study with 496 EOC cases and 906 controls, lifetime occupational histories were collected and used to calculate cumulative years of shift work exposure, average number of night shifts per month, and average number of consecutive night shifts per month. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1112DOI Listing

[Role of obstetricians and gynecologists in cervical cancer screening].

Authors:
J Zhao

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Mar;53(3):241-246

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100038, China.

Cervical cancer is the second leading cause of death due to gynecological malignancy in female patients. If obstetrician and gynecologists could master the mechanisms involved in the development of cell mutation and new tissue, the effectiveness of cervical cancer screening could be greatly increased. In the process of cervical cancer screening, if cervical tissue hyperplasia accompanied by bleeding could be identified by visual inspection and also in line with the conditions of abnormal cells and vascular proliferation, the cervical cancer would be highly suspicious at this time. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.03.002DOI Listing
March 2019
2 Reads

Massive single visit cervical pre-cancer and cancer screening in eastern Democratic Republic of Congo.

BMC Womens Health 2019 Mar 4;19(1):43. Epub 2019 Mar 4.

Departments of Emergency Medicine and Public Health Sciences, Queen's University, Kingston, Canada.

Background: In the Democratic Republic of Congo (DRC), practical and affordable strategies for cervical cancer screening are needed to detect and treat pre-cancerous and cancerous lesions in a timely fashion. This study presents the results of mass cervical cancer screenings in eastern DRC using a "screen and treat" approach.

Methods: In two mass cervical cancer screening campaigns, patients underwent a combination of visual inspection of the cervix with acetic acid, visual inspection of the cervix with Lugol iodine solution, and colposcopy with or without loop electrosurgical excision procedure. Read More

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http://dx.doi.org/10.1186/s12905-019-0737-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399865PMC
March 2019
3 Reads

Simple Hysterectomy for Cervical Cancer: Risk Factors for Failed Screening and Deviation From Screening Guidelines.

J Low Genit Tract Dis 2019 Apr;23(2):124-128

University of Oklahoma, Stephenson Cancer Center, Oklahoma City, OK.

Objective: The aim of this study is to describe risk factors associated with either false-negative cervical cancer screening or deviations from screening guidelines that result in incidentally found invasive cervical cancer at the time of simple hysterectomy for benign indications.

Materials And Methods: This is a retrospective review from 1990 to 2017 of subjects with incidental cervical cancer. Baseline demographics, preoperative evaluations, surgical data, and histopathologic characteristics were recorded. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000463DOI Listing
April 2019
1 Read

Evaluation of Folate Receptor-Mediated Cervical Dyeing as a Method for Detection of Cervical Lesions.

J Low Genit Tract Dis 2019 Apr;23(2):133-137

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Objectives: The aim of the study was to evaluate the performance of a folate receptor-mediated tumor detection (FRD) assay for detection of cervical high-grade lesions.

Materials And Method: A total of 1504 patients with abnormal cytology and/or positive human papillomavirus (HPV) testing during primary screening from November 2014 to August 2015 were enrolled. The patients were recruited from the Peking University People's Hospital and 12 other hospitals. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000411DOI Listing
April 2019
7 Reads
1.110 Impact Factor

Prevalence of Cervical Dysplasia in HIV-Positive and HIV-Negative Women at the Sihanouk Hospital Center of HOPE, Phnom Penh , Cambodia

Asian Pac J Cancer Prev 2019 Feb 28;20(2):653-659. Epub 2019 Feb 28.

Sihanouk Hospital Center of HOPE, Cambodia. Email:

Introduction: There is a high burden of cervical cancer in Cambodia, yet published data on the prevalence of cervical dysplasia and the risk factors contributing to the development of pre-cancerous lesions in Cambodian women is very limited. In addition, as it is well known that HIV positivity increases cervical cancer risk, it is important to quantify the prevalence of cervical dysplasia and carcinoma among Cambodian women living with HIV disease. Methods: A cross-sectional study was conducted with a sample of 499 HIV+ and 501 HIV- Cambodian women at the Sihanouk Hospital Center of HOPE. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.653DOI Listing
February 2019
2 Reads

Role of HPV DNA, HPV mRNA and cytology in the follow-up of women treated for cervical dysplasia.

APMIS 2019 Apr 27;127(4):196-201. Epub 2019 Feb 27.

Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-Spedali Civili, Brescia, Italy.

The aim of this study was to assess the role of cytology, human papilloma virus (HPV) DNA and human papilloma virus messenger RNA (HPV mRNA) assays in detecting cervical intraepithelial neoplasia grade 2+ (CNi 2+) (recurrences/persistence) during the follow-up of women after treatment of cervical intraepithelial lesion. This cross-sectional study was performed among 43 women treated for cervical intraepithelial neoplasia (CIN) between January 2014 and January 2017 at the Department of Obstetrics and Gynecology of Spedali Civili's Hospital, Brescia, Italy. Pap smear and cervical samples for HPV tests were collected during the follow-up visit. Read More

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http://dx.doi.org/10.1111/apm.12931DOI Listing
April 2019
1 Read

Budget impact analysis of cervical cancer screening in Portugal: comparison of cytology and primary HPV screening strategies.

BMC Public Health 2019 Feb 26;19(1):235. Epub 2019 Feb 26.

Roche Diagnostics, Almere, the Netherlands.

Background: Primary Human Papilloma Virus (HPV) testing is the currently recommended cervical cancer (CxCa) screening strategy by the Portuguese Society of Gynecology (SPG) clinical consensus. However, primary HPV testing has not yet been adopted by the Portuguese organized screening programs. This modelling study compares clinical benefits and costs of replacing the current practice, namely cytology with ASCUS HPV triage, with 2 comparative strategies: 1) HPV (pooled) test with cytology triage, or 2) HPV test with 16/18 genotyping and cytology triage, in organized CxCa screenings in Portugal. Read More

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http://dx.doi.org/10.1186/s12889-019-6536-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391842PMC
February 2019
1 Read

Prospective cohort study examining cervical cancer screening methods in HIV-positive and HIV-negative Cambodian Women: a comparison of human papilloma virus testing, visualization with acetic acid and digital colposcopy.

BMJ Open 2019 Feb 24;9(2):e026887. Epub 2019 Feb 24.

Department of Gynecology, Sihanouk Hospital Center of Hope, Phnom Penh, Cambodia.

Objectives: Logistical and economic issues make traditional cytology-based cervical cancer screening challenging in developing countries. Alternative, cost-effective, screening strategies must be developed to screen millions of women in resource-poor countries such as Cambodia.

Design: A prospective cohort study during which all women underwent four cervical cancer screening methods: (1) self-sampled human papilloma virus (HPV) testing (careHPV system), (2) clinician-collected HPV testing, (3) visualization with acetic acid (VIA) and (4) digital colposcopy (DC) with the Enhanced Visual Assessment System (EVA). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443060PMC
February 2019
1 Read

Comparison of Colposcopic Biopsy Results of Patients Who have Cytomorphological Normal but HPV 16-18 or Other High-Risk HPV Subtypes Positive

Asian Pac J Cancer Prev 2019 Feb 26;20(2):417-420. Epub 2019 Feb 26.

Atatürk Research and Training Hospital, Department of Gynecology and Obstetrics, İzmir Katip Çelebi University, Turkey. Email:

Objective: Current guidelines suggest annual co-test follow-up in non-16/18 high-risk HPV positive patients without abnormal cytologic findings. Considering the relatively high false-negative rates of cervical cytology, a follow-up period of one year might constitute an additional risk for development of cervical malignancies in these patients. The current study aims to evaluate colposcopic biopsy results of cytologically normal patients detected to carry high risk HPV by screening tests. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.417DOI Listing
February 2019
1 Read

Prevalence of epithelial abnormalities and high-risk human papilloma virus in cervicovaginal Pap smears of population subgroups as a guide toward evidence-based best practice.

Diagn Cytopathol 2019 Feb 23. Epub 2019 Feb 23.

Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.

Background: The 2012 American Society for Colposcopy and Cervical Pathology Consensus Guidelines provide information for managing abnormal cervical cancer screening tests and cancer precursors. According to these guidelines for Pap smear diagnosis of Atypical squamous cells of undetermined significance, reflex high risk (HR) human papilloma virus (HPV) genotyping is required among women 21 years of age or older. Whereas, in women of 30 to 65 years of age, HR-HPV can be ordered by the clinicians as part of co-testing with any diagnosis and every 5 years with a negative Cervico-Vaginal Pap test (CVPT). Read More

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http://dx.doi.org/10.1002/dc.24158DOI Listing
February 2019
3 Reads

Treatment of first-void urine with Aptima Transfer Solution increases detection of high-risk HPV E6/E7 mRNA.

J Virol Methods 2019 May 21;267:48-52. Epub 2019 Feb 21.

McMaster University, Hamilton, ON, Canada. Electronic address:

Because of its non-invasive nature urine testing may enable increased screening for HPV in women who avoid cervical sampling. Comparisons have shown fewer HPV positives in urine. The objectives were to compare first-void urine (FVU) treated with proteinase K (PK) to untreated FVU and cervical samples collected from women attending a colposcopy clinic using an Aptima HPV mRNA assay, and comparing the HPV rates to cytology and pathology results. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183047
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http://dx.doi.org/10.1016/j.jviromet.2019.02.007DOI Listing
May 2019
5 Reads

Two-Year Results of Community-Based Screening Program for Human Papilloma Virus DNA in Çorum Province.

Turk Patoloji Derg 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology, Hitit University, Faculty of Medicine, ÇORUM, TURKEY.

Objective: The Turkish Ministry of Health started a community-based screening program using Human Papilloma Virus (HPV) DNA in 2014. In our study, we aimed to investigate the results of this survey in Çorum province between the years of 2016-17 to determine the shortcomings and deficiencies in practice.

Material And Method: All of the women between the ages of 30 and 65 years who had undergone High risk HPV DNA screening in Çorum province between 2016 and 2017 were included in the study. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01452DOI Listing
February 2019
1 Read

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries - a Questionnaire-based Study.

Geburtshilfe Frauenheilkd 2019 Feb 18;79(2):189-197. Epub 2019 Feb 18.

Klinik für Frauenheilkunde und Geburtshilfe, Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum, Herne, Germany.

In connection with the reorganisation of cervical carcinoma screening, the importance of colposcopy as an integral part of the planned series of clarification testing will greatly increase. Quality standards for performing the colposcopic examination should therefore be defined in detail. A precondition for this is surveying the current standard in clinical practice. Read More

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http://dx.doi.org/10.1055/a-0828-7831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379162PMC
February 2019
1 Read

Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 2 on Triage, Treatment and Follow-up.

Geburtshilfe Frauenheilkd 2019 Feb 18;79(2):160-176. Epub 2019 Feb 18.

Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Hannover, Germany.

Annual opportunistic screening for cervical carcinoma has been done in Germany since 1971. The creation of this S3 guideline meets an important need, outlined in the National Cancer Plan, with regard to screening for cervical cancer, as this guideline aims to provide important information and support for planned organized screening for cervical cancer in Germany. With the financial support of German Cancer Aid, 21 professional societies developed evidence-based statements and recommendations (classified using the GRADE system) for the screening, management and treatment of precancerous conditions of the cervix. Read More

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http://dx.doi.org/10.1055/a-0828-7722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379166PMC
February 2019

Post-Colposcopy Management and Progression Predictors of Biopsy-Proven CIN1 in Women Under 25 Years.

J Obstet Gynaecol Can 2019 Mar 27;41(3):292-299. Epub 2018 Oct 27.

Department of Obstetrics and Gynecology, Queen Elizabeth II Health Sciences Centre, Halifax, NS.

Objective: The post-colposcopy management and outcome of cervical intraepithelial neoplasia grade 1 (CIN1) in women under 25 years of age was reviewed, and potential predictors for progression were identified.

Methods: Women under 25 with biopsy-proven CIN1 between January 1, 2010, and December 31, 2012 who were seen in the colposcopy clinic at the Queen Elizabeth II Hospital in Halifax, Nova Scotia were retrospectively reviewed. The regression, persistence, and progression rates of CIN1 were evaluated, and the relevant behavioural and biologic factors were reviewed. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.06.021DOI Listing
March 2019
3 Reads

Overcoming Barriers to Cervical Screening Among Pacific Women: A Narrative Review.

Health Equity 2019 14;3(1):22-29. Epub 2019 Feb 14.

Centre for Midwifery and Women's Health Research, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.

This narrative review explores the barriers and facilitators for Pacific women accessing the cervical screening pathway. Despite organized cervical screening in New Zealand, Pacific women still face significant health disparities in regard to cervical cancer incidence and mortality and access to colposcopy services. Providing a narrative synthesis of the available literature examining Pacific women and the barriers and facilitators to the cervical screening pathway may provide some insight into the provision of primary and secondary health services for Pacific women. Read More

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http://dx.doi.org/10.1089/heq.2018.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379043PMC
February 2019
2 Reads

Molecular Diagnosis of Human Papilloma Virus by PCR.

Mymensingh Med J 2019 Jan;28(1):175-181

Dr Faijun Nahar, Assistant Professor, Department of Microbiology, President Abdul Hamid Medical College, Kishoreganj, Bangladesh.

Cervical cancer is a major world health problem and the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. Read More

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January 2019
8 Reads

Distribution of HPV-16 and HPV-18 from the Patients Attending At Mymensingh Medical College Hospital by Newly Developed Oncoprotein Detection Assay.

Mymensingh Med J 2019 Jan;28(1):31-36

Dr Sahida Abedin, Lecturer, Department of Virology, MMC, Mymensingh, Bangladesh; E-mail:

Cervical cancer is one of cause of death in women in many developing countries. Persistent infection with Human Papilloma Virus (HPV), primarily high risk types 16 and 18, is recognized as a causal and essential factor for the development of cervical cancer. The objective of this cross sectional observational study is to detect the distribution of HPV-16 and HPV-18 among Onco E6 positive cases. Read More

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January 2019
3 Reads

Low-Cost Instructional Apparatus to Improve Training for Cervical Cancer Screening and Prevention.

Obstet Gynecol 2019 Mar;133(3):559-567

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407823PMC
March 2019
4 Reads

Evaluation of p16/Ki-67 dual staining in the detection of cervical precancer and cancer in China.

Cancer Epidemiol 2019 Apr 8;59:123-128. Epub 2019 Feb 8.

Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. Electronic address:

Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Read More

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http://dx.doi.org/10.1016/j.canep.2018.12.013DOI Listing
April 2019
2 Reads

An unusual cause of postmenopausal vaginal haemorrhage: a case report.

BMC Womens Health 2019 Feb 7;19(1):31. Epub 2019 Feb 7.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, 145, Guang-yuan Road, Xuhui District, Shanghai, 200030, China.

Background: Post-menopause vaginal haemorrhage is typically related to gynaecological malignancies. Bleeding from vaginal varices rarely occurs, especially in nonpregnant women. Moreover, nonpregnancy-related causes of vaginal varicosities include portal hypertension, especially that caused by liver cirrhosis, pelvic congestion syndrome and Klippel-Trenaunay syndrome or Parkes-Weber syndrome. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s12905-019-0731-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367833PMC
February 2019
4 Reads
1.657 Impact Factor

Primary cervical screening with high risk human papillomavirus testing: observational study.

BMJ 2019 Feb 6;364:l240. Epub 2019 Feb 6.

Division of Cancer Sciences, University of Manchester and Manchester NIHR BRC, Manchester, UK.

Objective: To provide the first report on the main outcomes from the prevalence and incidence rounds of a large pilot of routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous primary liquid based cytology screening.

Design: Observational study.

Setting: The English Cervical Screening Programme. Read More

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http://dx.doi.org/10.1136/bmj.l240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364146PMC
February 2019
3 Reads

Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study.

BMC Womens Health 2019 Feb 6;19(1):30. Epub 2019 Feb 6.

Department of Gynecology and Obstetrics, Østfold Hospital Trust, Kalnes, Norway.

Background: Local treatment for cervical intraepithelial neoplasia (CIN) by Loop Electrosurgical Excision Procedure (LEEP) has been correlated with reproductive morbidity, while the cervicovaginal microbiota is also known to affect the risk of preterm delivery. CIN and treatment by LEEP might change the cervical microbiota. The main aim of this study was to describe the cervical microbiota before and after LEEP and assess its associaton with cone depth and HPV persistence. Read More

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http://dx.doi.org/10.1186/s12905-019-0727-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364458PMC
February 2019
1 Read

The effect of an animation video on consultation time, anxiety and satisfaction in women with abnormal cervical cytology: Animation video reduces colposcopy time.

Prev Med Rep 2019 Mar 15;13:238-243. Epub 2019 Jan 15.

Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.

The objective was to assess whether supplementing hospital-dependent standard information with a hospital-independent animation video might reduce consultation time, pre-colposcopy anxiety levels and increase post-colposcopy satisfaction. Between November 2016 and May 2018, women were included if they were referred to the department of Obstetrics and Gynaecology in one of the three participating hospitals in the Netherlands due to an abnormal cervical smear. Exclusion criteria were colposcopy in the medical history or inability to understand, speak or read Dutch. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350223PMC
March 2019
1 Read

Cost-effectiveness evaluation of HPV self-testing offered to non-attendees in cervical cancer screening in Switzerland.

Gynecol Oncol 2019 Apr 1;153(1):92-99. Epub 2019 Feb 1.

Division of Clinical Epidemiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.

Objective: About 30% of women who are eligible for cervical cancer (CC) screening remain un-screened or under-screened in Switzerland. HPV testing on self-collected vaginal samples (Self-HPV) has shown to be more sensitive than cytology while also reaching non-attendees. The objective of this study was to explore the cost-effectiveness of offering Self-HPV to non-attendees in Switzerland. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193006
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http://dx.doi.org/10.1016/j.ygyno.2019.01.021DOI Listing
April 2019
9 Reads
3.774 Impact Factor

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
5 Reads

Factors Related to Overtreatment in the See-and-Treat Approach: A Retrospective Multicentric Observational Study.

J Low Genit Tract Dis 2019 Apr;23(2):129-132

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objective: The aim of the study was to evaluate the association between colposcopic features, age, menopausal status, and overtreatment in women subjected to "see-and-treat" approach, to identify subgroups of patients in which this approach could be more appropriate.

Materials And Methods: Retrospective multicentric cohort study conducted on women older than 25 years, with a high-grade squamous cytological report and a visible squamocolumnar junction, in which colposcopy and the excisional procedure were performed at the same time without a previous cervical biopsy (see and treat). Overtreatment was defined as histopathological finding of cervical intraepithelial lesion grade 1 or normal tissue. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000455DOI Listing
April 2019
13 Reads