8,856 results match your criteria Colposcopy


Molecular Diagnosis of Human Papilloma Virus by PCR.

Mymensingh Med J 2019 Jan;28(1):175-181

Dr Faijun Nahar, Assistant Professor, Department of Microbiology, President Abdul Hamid Medical College, Kishoreganj, Bangladesh.

Cervical cancer is a major world health problem and the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. Read More

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January 2019

Distribution of HPV-16 and HPV-18 from the Patients Attending At Mymensingh Medical College Hospital by Newly Developed Oncoprotein Detection Assay.

Mymensingh Med J 2019 Jan;28(1):31-36

Dr Sahida Abedin, Lecturer, Department of Virology, MMC, Mymensingh, Bangladesh; E-mail:

Cervical cancer is one of cause of death in women in many developing countries. Persistent infection with Human Papilloma Virus (HPV), primarily high risk types 16 and 18, is recognized as a causal and essential factor for the development of cervical cancer. The objective of this cross sectional observational study is to detect the distribution of HPV-16 and HPV-18 among Onco E6 positive cases. Read More

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January 2019
1 Read

Low-Cost Instructional Apparatus to Improve Training for Cervical Cancer Screening and Prevention.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003140DOI Listing
February 2019
1 Read

Evaluation of p16/Ki-67 dual staining in the detection of cervical precancer and cancer in China.

Cancer Epidemiol 2019 Feb 7;59:123-128. Epub 2019 Feb 7.

Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. Electronic address:

Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Read More

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http://dx.doi.org/10.1016/j.canep.2018.12.013DOI Listing
February 2019
1 Read

An unusual cause of postmenopausal vaginal haemorrhage: a case report.

BMC Womens Health 2019 Feb 7;19(1):31. Epub 2019 Feb 7.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, 145, Guang-yuan Road, Xuhui District, Shanghai, 200030, China.

Background: Post-menopause vaginal haemorrhage is typically related to gynaecological malignancies. Bleeding from vaginal varices rarely occurs, especially in nonpregnant women. Moreover, nonpregnancy-related causes of vaginal varicosities include portal hypertension, especially that caused by liver cirrhosis, pelvic congestion syndrome and Klippel-Trenaunay syndrome or Parkes-Weber syndrome. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0731-4DOI Listing
February 2019
2 Reads

Primary cervical screening with high risk human papillomavirus testing: observational study.

BMJ 2019 Feb 6;364:l240. Epub 2019 Feb 6.

Division of Cancer Sciences, University of Manchester and Manchester NIHR BRC, Manchester, UK.

Objective: To provide the first report on the main outcomes from the prevalence and incidence rounds of a large pilot of routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous primary liquid based cytology screening.

Design: Observational study.

Setting: The English Cervical Screening Programme. Read More

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http://dx.doi.org/10.1136/bmj.l240DOI Listing
February 2019
2 Reads

Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study.

BMC Womens Health 2019 Feb 6;19(1):30. Epub 2019 Feb 6.

Department of Gynecology and Obstetrics, Østfold Hospital Trust, Kalnes, Norway.

Background: Local treatment for cervical intraepithelial neoplasia (CIN) by Loop Electrosurgical Excision Procedure (LEEP) has been correlated with reproductive morbidity, while the cervicovaginal microbiota is also known to affect the risk of preterm delivery. CIN and treatment by LEEP might change the cervical microbiota. The main aim of this study was to describe the cervical microbiota before and after LEEP and assess its associaton with cone depth and HPV persistence. Read More

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http://dx.doi.org/10.1186/s12905-019-0727-0DOI Listing
February 2019
1 Read

The effect of an animation video on consultation time, anxiety and satisfaction in women with abnormal cervical cytology: Animation video reduces colposcopy time.

Prev Med Rep 2019 Mar 15;13:238-243. Epub 2019 Jan 15.

Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.

The objective was to assess whether supplementing hospital-dependent standard information with a hospital-independent animation video might reduce consultation time, pre-colposcopy anxiety levels and increase post-colposcopy satisfaction. Between November 2016 and May 2018, women were included if they were referred to the department of Obstetrics and Gynaecology in one of the three participating hospitals in the Netherlands due to an abnormal cervical smear. Exclusion criteria were colposcopy in the medical history or inability to understand, speak or read Dutch. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350223PMC
March 2019
1 Read

Cost-effectiveness evaluation of HPV self-testing offered to non-attendees in cervical cancer screening in Switzerland.

Gynecol Oncol 2019 Feb 1. Epub 2019 Feb 1.

Division of Clinical Epidemiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.

Objective: About 30% of women who are eligible for cervical cancer (CC) screening remain un-screened or under-screened in Switzerland. HPV testing on self-collected vaginal samples (Self-HPV) has shown to be more sensitive than cytology while also reaching non-attendees. The objective of this study was to explore the cost-effectiveness of offering Self-HPV to non-attendees in Switzerland. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193006
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http://dx.doi.org/10.1016/j.ygyno.2019.01.021DOI Listing
February 2019
6 Reads
3.774 Impact Factor

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
3 Reads

Factors Related to Overtreatment in the See-and-Treat Approach: A Retrospective Multicentric Observational Study.

J Low Genit Tract Dis 2019 Jan 30. Epub 2019 Jan 30.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objective: The aim of the study was to evaluate the association between colposcopic features, age, menopausal status, and overtreatment in women subjected to "see-and-treat" approach, to identify subgroups of patients in which this approach could be more appropriate.

Materials And Methods: Retrospective multicentric cohort study conducted on women older than 25 years, with a high-grade squamous cytological report and a visible squamocolumnar junction, in which colposcopy and the excisional procedure were performed at the same time without a previous cervical biopsy (see and treat). Overtreatment was defined as histopathological finding of cervical intraepithelial lesion grade 1 or normal tissue. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000455DOI Listing
January 2019
2 Reads

Cervical Cancer and Its Precursors: A Preventative Approach to Screening, Diagnosis, and Management.

Prim Care 2019 Mar 22;46(1):117-134. Epub 2018 Dec 22.

Department of Obstetrics and Gynecology, University of California, Davis, Davis, CA, USA.

Cervical cancer affects the cells lining the cervix, most commonly occurring in the cells of the transformation zone. Screening for cervical cancer looks to detect preinvasive disease, allowing for intervention before invasive disease develops. an assessment of individual risk factors, Selection of screening method depends on patient age, her screening history and results, and resources available. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00954543183009
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http://dx.doi.org/10.1016/j.pop.2018.10.011DOI Listing
March 2019
9 Reads

The cost-effectiveness of implementing HPV testing for cervical cancer screening in El Salvador.

Int J Gynaecol Obstet 2019 Jan 31. Epub 2019 Jan 31.

Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objective: To assess the cost-effectiveness of HPV-based screening and management algorithms for HPV-positive women in phase 2 of the Cervical Cancer Prevention in El Salvador (CAPE) demonstration, relative to the status quo of Pap-based screening.

Methods: Data from phase 2 of the CAPE demonstration (n=8000 women) were used to inform a mathematical model of HPV infection and cervical cancer. The model was used to project the lifetime health and economic outcomes of HPV testing every 5 years (age 30-65 years), with referral to colposcopy for HPV-positive women; HPV testing every 5 years (age 30-65 years), with immediate cryotherapy for eligible HPV-positive women; and Pap testing every 2 years (age 20-65 years), with referral to colposcopy for Pap-positive women. Read More

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http://doi.wiley.com/10.1002/ijgo.12773
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http://dx.doi.org/10.1002/ijgo.12773DOI Listing
January 2019
3 Reads

MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy.

BMC Cancer 2019 Jan 30;19(1):112. Epub 2019 Jan 30.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China.

Background: Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by colposcopy guided biopsy is recommended conservative follow-up, although some of these lesions are actually high-grade lesions, which are missed on an initial colposcopy. Therefore, in this work, we evaluate the potential role of miRNA detection in cervical exfoliated cells in a clinic-based population for predicting missed high-grade lesions in women diagnosed with LSIL/CIN1 after colposcopy-guided biopsy.

Methods: A total number of 177 women with a diagnosis of LSIL/CIN1 obtained by colposcopy-guided biopsy were grouped into two categories according to the histology of the conization specimens: consistent LSIL/CIN1 group (surgical pathology consistent with colposcopic diagnosis) and missed high-grade lesion group (surgical pathology found high-grade lesion). Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5311-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354336PMC
January 2019
9 Reads

Use of HPV testing in cervical cancer screening services in Mexico, 2008-2018: a nationwide database study.

Salud Publica Mex 2018 Nov-Dic;60(6):722-733

Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México.

Objective: To describe the methods of a study aimed at evaluating high risk-HPV (hrHPV)-based screening and cervical cytology as triage compared to conventional cervical cytology as primary screening in the detection of grade 2+ cervical intraepithelial neoplasia in the National Cancer Screening Program (NCSP) of Mexico.

Materials And Methods: We will use information originated from the Womens Cancer Information System of Mexico regarding cervical cancer from 2008 to 2018. The database includes cytology results, diagnostic confirmation by histopathology and/or treatment colposcopy. Read More

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http://dx.doi.org/10.21149/9891DOI Listing

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
8 Reads

Observed Colposcopy Practice in US Community-Based Clinics: The Retrospective Control Arm of the IMPROVE-COLPO Study.

J Low Genit Tract Dis 2019 Jan 25. Epub 2019 Jan 25.

Oklahoma Cancer Specialists and Research Institute and University of Oklahoma School of Community Medicine, Tulsa, OH.

Objective: The aim of the study was to characterize colposcopy practice and management of women with cervical abnormalities in US community-based clinics.

Materials And Methods: IMPROVE-COLPO was a 2-arm study of colposcopy patients with an abnormal screening result. The prospective arm recruited women to undergo examination with a commercial digital colposcope. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000454DOI Listing
January 2019
2 Reads

Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy.

Acta Obstet Gynecol Scand 2019 Jan 28. Epub 2019 Jan 28.

Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

Introduction: The aim of this study was to describe trends in diagnosis and treatment of women referred from screening with cervical intraepithelial neoplasia (CIN) in the Netherlands, compare this to national guidelines and identify potential areas for improvement for the new primary high-risk HPV screening program.

Material And Methods: We conducted a population-based cohort study using data from Dutch pathology archive. Women aged 29 to 63 years who took part in the Dutch cervical screening program between 1 January 2005 to 31 December 2014 were selected. Read More

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http://dx.doi.org/10.1111/aogs.13547DOI Listing
January 2019
2 Reads

Performance of an HPV 16/18 E6 oncoprotein test for detection of cervical precancer and cancer.

Int J Cancer 2019 Jan 26. Epub 2019 Jan 26.

Prevention and Implementation Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

HPV testing is a better alternative for cervical cancer screening, but additional procedures are required for triage of HPV positive women. HPV encoded oncoproteins E6 and E7, as the main effectors of HPV carcinogenicity represent promising triage alternatives. To evaluate performance of the test, we included 155 women from a screening study and 59 from the same referral population attending colposcopy and with precancerous lesions. Read More

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http://dx.doi.org/10.1002/ijc.32156DOI Listing
January 2019
2 Reads

The Impact of Triage for Atypical Squamous Cells of Undetermined Significance with Human Papillomavirus Testing in Cervical Cancer Screening in Japan

Asian Pac J Cancer Prev 2019 Jan 25;20(1):81-85. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan. Email:

Background: One of the features of cervical cancer screening using the combination of cytology and human papillomavirus (HPV) testing is the triage for atypical squamous cells of undetermined significance (ASC-US). The effectiveness of the triage has been recognized widely. However, there are few reports evaluating this triage process in Japan. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.81DOI Listing
January 2019
1 Read

Clinical performance of Anyplex II HPV28 by human papillomavirus type and viral load in a referral population.

PLoS One 2019 23;14(1):e0210997. Epub 2019 Jan 23.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.

Anyplex II HPV28 (`Anyplex`) is a semi-quantitative DNA PCR assay divided into set A, comprising 14 high risk (hr)HPV types; and set B, comprising 5 possibly hrHPV types and 9 low risk (lr)HPV types. We compared the ability of Anyplex to that of Hybrid Capture 2 (HC2) and PreTect HPV-Proofer (`Proofer`) to detect cervical intraepithelial neoplasia grade two or worse (CIN2+) by HPV types and viral load. This cross-sectional study included 296 women referred to colposcopy with abnormal cervical cytology and/or persistent HPV infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343909PMC
January 2019
9 Reads

Better resource utilization and quality of care for cervical cancer screening in low-resourced districts using an internet-based expert system.

Technol Health Care 2019 Jan 8. Epub 2019 Jan 8.

Department of Biomedical Engineering, University of Houston, Houston, TX, USA.

Background: Screening tools are critical in the early prevention of cervical cancers. Acetic-acid based colposcopy test provides an affordable solution but is often challenged by the lack of experienced doctors in under-developed districts.

Objective: To evaluate the feasibility of an internet-based expert system to better utilize the expert knowledge. Read More

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http://dx.doi.org/10.3233/THC-181577DOI Listing
January 2019
2 Reads
0.636 Impact Factor

Colposcopy: a closer look into its past, present and future.

BJOG 2019 Mar 17;126(4):543. Epub 2019 Jan 17.

Canberra health services and australian national university, Canberra, NSW, Australia.

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http://dx.doi.org/10.1111/1471-0528.15554DOI Listing

Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory.

Geburtshilfe Frauenheilkd 2018 Dec 14;78(12):1232-1244. Epub 2018 Dec 14.

Universitätsklinik für Frauenheilkunde, Medizinische Universität Wien, Wien, Austria.

On January 1st, 2018, the ÖGZ (Austrian Society of Cytology) revised its cytological nomenclature to make it more similar to the 2015 Bethesda system. Following these changes, the Austrian Society of Gynecology and Obstetrics felt it necessary to revise the approach currently used in Austria to diagnose and treat CIN and to review the procedures to be followed when the quality of cytological specimens is unsatisfactory. It was not possible to adopt the German S3 guideline "Prevention of Cervical Cancer" in its entirety, because the Munich III gynecological cytology nomenclature used in Germany is not used in Austria. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0764-4875
Publisher Site
http://dx.doi.org/10.1055/a-0764-4875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301212PMC
December 2018
3 Reads

Cervical Digital Photography: An Alternative Method to Colposcopy.

J Obstet Gynaecol Can 2019 Jan 14. Epub 2019 Jan 14.

Postgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective: This study sought to evaluate the performance of cervical digital photography as an alternative to colposcopy.

Methods: Colposcopy and cervical digital photography were performed on 228 women. The cervical digital photographs were evaluated through the Internet by three colposcopy experts. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.10.025DOI Listing
January 2019
3 Reads

HPV Testing With 16, 18, and 45 Genotyping Stratifies Cancer Risk for Women With Normal Cytology: Data From the Baseline Phase of the Onclarity Trial.

Am J Clin Pathol 2019 Jan 14. Epub 2019 Jan 14.

Becton, Dickinson and Company, BD Life Sciences-Diagnostic Systems, Sparks, MD.

Objectives: To determine the BD Onclarity human papillomavirus (HPV) assay performance and risk values for cervical intraepithelial neoplasia grade 2 (CIN2) or higher and cervical intraepithelial neoplasia grade 3 (CIN3) or higher during Papanicolaou/HPV cotesting in a negative for intraepithelial lesions or malignancies (NILM) population.

Methods: In total, 22,383 of the 33,858 enrolled women were 30 years or older with NILM cytology. HPV+ and a subset of HPV- patients (3,219/33,858 combined; 9. Read More

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http://dx.doi.org/10.1093/ajcp/aqy169DOI Listing
January 2019
2 Reads

Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China.

Int J Gynecol Cancer 2019 Jan;29(1):23-27

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Objective: To evaluate the use of a portable, rechargeable colposcope combined with human papillomavirus (HPV) testing, as compared with HPV testing alone, for screening of cervical cancer and pre-cancerous lesions.

Methods: This was a cross-sectional study among 488 women in Baoshan County, Yunnan. The women underwent HPV testing followed by Gynocular portable colposcopy with visual inspection with acetic acid. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000006
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http://dx.doi.org/10.1136/ijgc-2018-000006DOI Listing
January 2019
6 Reads

Stratified risk of high-grade cervical disease using onclarity HPV extended genotyping in women, ≥25 years of age, with NILM cytology.

Gynecol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Becton, Dickinson and Company, BD Life Sciences, - Diagnostic Systems, 7 Loveton Circle, Sparks, MD 21152, USA. Electronic address:

Objectives: Increasing evidence suggests that extended human papillomavirus (HPV) genotyping (beyond 16/18) is effective for risk stratification in women with normal cytology. This report provides extended genotyping results, using the BD Onclarity HPV Assay, for individual genotypes HPV16, 18, 31, 45, 51, and 52 ̶ and three pooled genotype results for HPV33/58, 35/39/68, and 56/59/66.

Methods: 27,037 women with normal cytology, ≥25 years, were enrolled into the Onclarity HPV trial during routine screening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183153
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http://dx.doi.org/10.1016/j.ygyno.2018.12.024DOI Listing
January 2019
5 Reads

The promising role of PAX1 (aliases: HUP48, OFC2) gene methylation in cancer screening.

Mol Genet Genomic Med 2019 Jan 12. Epub 2019 Jan 12.

Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Paired-box gene 1 (PAX1), a member of the PAX family, plays a role in pattern formation during embryogenesis, and might be essential for development of the vertebral column.

Methods: PAX1 is silenced by methylation in several cancers and is considered a tumor suppressor gene. Our previous studies reported PAX1 as hypermethylated in cervical cancer tissues, thereby suggesting it as a potential screening marker. Read More

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http://doi.wiley.com/10.1002/mgg3.506
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http://dx.doi.org/10.1002/mgg3.506DOI Listing
January 2019
5 Reads

Comparison of topical lidocaine spray with forced coughing in pain relief during colposcopic biopsy procedure: a randomised trial.

J Obstet Gynaecol 2019 Jan 11:1-5. Epub 2019 Jan 11.

b Department of Obstetrics and Gynecology, Medical Faculty , Yuzuncu Yil University , Van , Turkey.

Our objective was to compare the effectiveness of local lidocaine spray (LS) compared to forced coughing (FC) for relieving the pain during colposcopically guided cervical biopsies (CGBs). The study was a randomised study, which included patients with abnormal cervical cytologic results requiring a colposcopic biopsy procedure. The patients were randomly assigned to either the 10% LS or the FC groups before the biopsy procedure. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
Publisher Site
http://dx.doi.org/10.1080/01443615.2018.1538329DOI Listing
January 2019
5 Reads

Clinical significance of genotyping for human papillomavirus (HPV) 16 18/45 combined with cytology in cervical exfoliated cells in HPV oncogenic mRNA-positive women.

Gynecol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Gynecology, Huzhou Maternity&Child Health Care Hospital, Huzhou, Zhejiang Province, China. Electronic address:

Objectives: This study aimed to assess human papilloma virus (HPV) 16 18/45 typing test results combined with cytology for cervical exfoliated cells from women who screened positive in an HPV E6/E7 mRNA assay (Aptima HPV, AHPV).

Methods: In total, 3257 AHPV-positive women aged 25-65 years were underwent AHPV 16 18/45 Genotype assay (AHPV-GT) testing with cytology. Women were referred for colposcopy and further biopsy if indicated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183154
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http://dx.doi.org/10.1016/j.ygyno.2018.12.028DOI Listing
January 2019
13 Reads

Dynamics of genotype-specific HPV clearance and reinfection in rural Ghana may compromise HPV screening approaches.

Papillomavirus Res 2019 Jan 6;7:45-51. Epub 2019 Jan 6.

Clinic for Gynecology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany. Electronic address:

Persistent Human Papillomavirus (HPV) infection is a prerequisite for cervical cancer development. Few studies investigated clearance of high-risk HPV in low-and-middle-income countries. Our study investigated HPV clearance and persistence over four years in women from North Tongu District, Ghana. Read More

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http://dx.doi.org/10.1016/j.pvr.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350109PMC
January 2019
2 Reads

Self-collected Pap smears may provide an acceptable and effective method of cervical cancer screening.

Health Sci Rep 2018 May 6;1(5):e33. Epub 2018 Apr 6.

Monash University Melbourne Australia.

Background And Aims: The role of the Papanicolou (Pap) smear in the early detection and prevention of cervical cancer is well established. However, many women fail to undertake the test because of embarrassment or other reasons. To address this problem, we evaluated the feasibility of implementing self-sampling of cervical cytology as an alternative to clinician-collected Pap smears and compared it with the gold standard of colposcopy in terms of specificity. Read More

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http://doi.wiley.com/10.1002/hsr2.33
Publisher Site
http://dx.doi.org/10.1002/hsr2.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266357PMC
May 2018
5 Reads

EVALUATION OF RESIDUAL LESIONS FOLLOWING CONSERVATIVE TREATMENT OF HIGH GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA.

Georgian Med News 2018 Nov(284):13-18

University of Georgia, School of Health Sciences; Georgian National Screening Center; I. Javakhishvili Tbilisi State University, Georgia.

The purpose of this study was to determine the diagnostic value Pap smear test and colposcopy in Georgian National Screening Center, evaluation of efficiency of the excisional treatment and determining the main risk factors for prediction of residual/recurrent disease in patients with high-grade cervical intraepithelial neoplasia. We retrospectively analyzed 613 patients, who underwent excisional treatment of the cervix (LEEP). Follow-up was performed by Pap smear test, colposcopy and histamorphological examinations. Read More

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November 2018

Exploring the feasibility of using mobile phones to improve the management of clients with cervical cancer precursor lesions.

BMC Womens Health 2019 Jan 7;19(1). Epub 2019 Jan 7.

Women's Health Research Unit, Faculty of Health Sciences, School of Public Health and Family Medicine, University of Cape Town, Anzio Road. Observatory, Cape Town, 7925, South Africa.

Background: Cancer screening programs hold much potential for reducing the cervical cancer disease burden in developing countries. The aim of this study was to determine the feasibility of mobile health (mHealth) phone technology to improve management and follow-up of clients with cervical cancer precursor lesions.

Methods: A sequential mixed methods design was employed for this study. Read More

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http://dx.doi.org/10.1186/s12905-018-0702-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322222PMC
January 2019
2 Reads

Rates of regression of cervical dysplasia between initial biopsy and excisional procedure in routine clinical practice.

Arch Gynecol Obstet 2019 Jan 4. Epub 2019 Jan 4.

Department of Global Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.

Purpose: To determine rates and factors associated with regression of cervical intraepithelial neoplasia (CIN) 2 + between colposcopic biopsy and therapeutic excisional procedure in standard practice.

Methods: A retrospective chart review was performed for women undergoing a cervical excisional procedure for CIN 2 + at clinics at three academic institutions over a 3-year period. Cytology, histology, patient age and time-to-excision were analyzed to determine factors influencing rates of regression. Read More

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http://link.springer.com/10.1007/s00404-018-5026-8
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http://dx.doi.org/10.1007/s00404-018-5026-8DOI Listing
January 2019
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Introduction of a learning model for type 1 loop excision of the transformation zone of the uterine cervix in undergraduate medical students: a prospective cohort study.

Arch Gynecol Obstet 2019 Jan 4. Epub 2019 Jan 4.

Department of Gynecology, Obstetrics, and Reproductive Medicine, University Medical School of Saarland, Homburg, Germany.

Purpose: We address the impact of applying loop electrosurgical excision procedure (LEEP) under direct colposcopic vision teaching to our undergraduates using a self-developed simulation model and a standardized assessment to evaluate the progress of learning.

Methods: The undergraduate teaching module was composed of a theoretical course on cervical dysplasia, colposcopy, electrosurgery and excisional procedures of the uterine cervix. This was followed by hands-on practical rounds. Read More

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http://link.springer.com/10.1007/s00404-018-5019-7
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http://dx.doi.org/10.1007/s00404-018-5019-7DOI Listing
January 2019
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South African women's perspectives on self-sampling for cervical cancer screening: A mixed-methods study.

S Afr Med J 2018 Dec 13;109(1):47-52. Epub 2018 Dec 13.

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town, South Africa; SAMRC Gynaecological Cancer Research Centre, Faculty of Health Sciences, University of Cape Town, South Africa; Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Nigeria.

Background: Self-sampling as a method of screening for cervical cancer and its precursors is an attractive option for low-resource settings. However, to allow successful integration of self-sampling into national screening programmes, it is necessary to understand women's perceptions and beliefs surrounding this method of sampling the cervix.

Objectives: To explore women's attitudes to self-collection of samples for cervical screening in a low-resource setting in South Africa (SA). Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v109i1.13278DOI Listing
December 2018
2 Reads

[Analysis of cervical cancer screening results in women aged 50 and older in Beijing and Guizhou].

Authors:
G Z Guo Y Zhao

Zhonghua Zhong Liu Za Zhi 2018 Dec;40(12):922-926

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To analyze the screening results of cervical cancer in elderly women in Beijing and Guizhou. To compare the screening effectiveness of cervical cancer in elderly women in different areas. A retrospective analysis was performed on the screening data of elderly women (≥50 years) who had examination at cervical lesion clinic in Peking University People's Hospital and Affiliated Hospital of Guizhou Medical University from January 2013 to January 2014, with histopathology as the gold standard, to compare screening effectiveness of cervical cytology or HPV detection for elderly women in cervical cancer screening in the two regions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.12.010DOI Listing
December 2018

[Application of artificial intelligence in diagnosis of medical endoscope].

Zhonghua Zhong Liu Za Zhi 2018 Dec;40(12):890-893

School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Through a brief overview of the origin and development of artificial intelligence, the research progress of artificial intelligence in digestive endoscopy, ophthalmoscopy and electronic colposcopy was summarized, and the importance of its application was clarified. This article induced the main problems and suggestions of artificial intelligence in the development of medical endoscopes, and prospected the future application of artificial intelligence in medical endoscopy diagnosis. Read More

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http://doi.med.wanfangdata.com.cn/10.3760/cma.j.issn.0253-37
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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.12.003DOI Listing
December 2018
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Role of Screening History in Clinical Meaning and Optimal Management of Positive Cervical Screening Results.

J Natl Cancer Inst 2018 Dec 21. Epub 2018 Dec 21.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Background: Cervical cancer is caused by persistent human papillomavirus (HPV) infection. US consensus management guidelines for a positive cervical screening result typically focus on the current screening result only. A negative testing history may alter risk of the following positive screening results, caused by a new HPV infection, and therefore its optimal management. Read More

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http://dx.doi.org/10.1093/jnci/djy192DOI Listing
December 2018
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Mozart for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial.

Obstet Gynecol 2019 Jan;133(1):191

Department of Obstetrics and Gynecology, Northwestern University School of Medicine, Chicago, Illinois La Grange Park, Illinois.

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http://dx.doi.org/10.1097/AOG.0000000000003052DOI Listing
January 2019
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Management of HPV-positive women in cervical screening using results from two consecutive screening rounds.

Int J Cancer 2018 Nov 22. Epub 2018 Nov 22.

Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

We studied whether triage of human papillomavirus (HPV)-positive women participating in an HPV-based screening programme can be improved by including the HPV result at the previous screen in the triage algorithm. We analyzed data of a subgroup of 366 women from the POBASCAM trial, screened by cytology and HPV cotesting. Women were included if they tested HPV-positive in the second HPV-based screening round. Read More

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http://doi.wiley.com/10.1002/ijc.32004
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http://dx.doi.org/10.1002/ijc.32004DOI Listing
November 2018
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Isolation of Biopsy-Derived, Human Cervical Keratinocytes Propagated as Monolayer and Organoid Cultures.

Sci Rep 2018 Dec 14;8(1):17869. Epub 2018 Dec 14.

Department of Biology, Lakehead University, Thunder Bay ON, P7B 5E1, Canada.

The successful isolation and propagation of patient-derived keratinocytes from cervical lesions constitute a more appropriate model of cervical disease than traditional cervical cancer-derived cell lines such as SiHa and CaSki. Our aim was to streamline the growth of patient-obtained, cervical keratinocytes into a reproducible process. We performed an observational case series study with 60 women referred to colposcopy for a diagnostic biopsy. Read More

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http://dx.doi.org/10.1038/s41598-018-36150-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294766PMC
December 2018
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Data on post-partum evaluation of women with abnormal cervical cytology in pregnancy.

Data Brief 2018 Dec 22;21:2405-2409. Epub 2018 Nov 22.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Via F. Gallini 2, Aviano, Italy.

During pregnancy, the only diagnosis that may alter management is invasive cancer. Thus, the primary aim of the cytological screening and subsequent colposcopy performed during pregnancy should be the exclusion of invasive cancer, "Practice Bulletin No. 140: management of abnormal cervical cancer screening test results and cervical cancer precursors," (American College of Obstetricians and Gynecologists, 2013) [1]. Read More

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http://dx.doi.org/10.1016/j.dib.2018.11.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282187PMC
December 2018
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Information needs of young women vaccinated against HPV attending colposcopy: a qualitative study.

BMC Womens Health 2018 Dec 12;18(1):200. Epub 2018 Dec 12.

Obstetrics and Gynaecology, Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Background: Previous studies have shown that woman attending their first cervical screening or colposcopy appointment experience negative emotions, primarily anxiety and fear. With the introduction of the Human Papillomavirus (HPV) vaccine, it is unknown whether these emotions will have altered or whether the information needs of vaccinated women will have changed. The objective of this study is to determine the knowledge, understanding and concerns that young women have about HPV when attending colposcopy and whether their information needs are met. Read More

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http://dx.doi.org/10.1186/s12905-018-0691-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292045PMC
December 2018
1 Read

[Relation of cervical cancer with the results of human papillomavirus (HPV) screening carried out via hybrid capture 2 method on 52.000 women in Erzurum].

Mikrobiyol Bul 2018 Oct;52(4):367-375

Providencial Health Director, Erzurum, Turkey.

Cervical cancer is a common female cancer that could be diagnosed early with screening methods. Almost all cases are caused by human papilloma virus (HPV) infection. Therefore, detecting the presence of HPV DNA is important for early diagnosis and treatment. Read More

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http://dx.doi.org/10.5578/mb.67419DOI Listing
October 2018
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[Analysis of the first test of ASC-US smears by general practitioners of the Maine-et-Loire in 2014.]

Sante Publique 2018 July August;30(4):499-505

Introduction: During the study, the HAS (French Board of Health) recommended 3 options for the first test (C1) in case of presence of ASC-US: a smear to be carried out after 6 months, an HPV test or a colposcopy.Our main objective was to find out which C1 option was chosen. The secondary objectives were to evaluate the number of C1's carried out by general practitioners, the follow-up rate and that of adapted C1 smear reports. Read More

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http://dx.doi.org/10.3917/spub.185.0499DOI Listing
February 2019

MASP-1 and MASP-2 Serum Levels Are Associated With Worse Prognostic in Cervical Cancer Progression.

Front Immunol 2018 23;9:2742. Epub 2018 Nov 23.

Department of Gynecology, Clinical Hospital, Federal University of Parana, Curitiba, Brazil.

MBL-associated serine proteases (MASP-1, MASP-2, MASP-3, MAp-44, and MAp-19) are key factors in the activation of the lectin pathway of complement. Serum levels of these components have been associated with recurrence and poor survival of some types of cancer, such as colorectal and ovarian cancer. In this investigation, we determined the serum levels of MASP-1, MASP-2, MASP-3, MAp-44, and MAp-19 in patients with cervical cancer and cervical intraepithelial neoplasia (CIN). Read More

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http://dx.doi.org/10.3389/fimmu.2018.02742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265985PMC
November 2018
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Clinical validation of the Cervista high-risk human papillomavirus test in Chinese women from Fujian province: a cross-sectional study.

Ther Clin Risk Manag 2018 16;14:2243-2253. Epub 2018 Nov 16.

Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China,

Purpose: To estimate the high-risk human papillomavirus (HR-HPV) prevalence in a hospital-based population using the Cervista and to determine the clinical value and significance of Cervista for cervical cancer screening in Fujian Province, China.

Patients And Methods: In a hospital-based population, a total of 10,771 women from the Fujian Province were screened for cervical cancer and precancerous lesions using the thinprep cytologic test (TCT) and/or the Cervista. Women with HR-HPV infection and/or abnormal TCT were referred for colposcopy and biopsy. Read More

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http://dx.doi.org/10.2147/TCRM.S179334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247958PMC
November 2018
2 Reads