159,945 results match your criteria Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland[Journal]


M51R and Delta-M51 matrix protein of the vesicular stomatitis virus induce apoptosis in colorectal cancer cells.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Cell and Molecular Research center, Golestan University of Medical Science, 1 Shastcola Ave, 5 km Sari Rd, Gorgan, Iran.

Colorectal cancer (CRC) is the third most common cancer in both men and women. Oncolytic viral-based therapy methods seem to be promising for CRC treatment. Vesicular stomatitis virus (VSV) is considered as a potent candidate in viral therapy for several tumors. Read More

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http://dx.doi.org/10.1007/s11033-019-04799-3DOI Listing

Comparative evaluation of novel screening strategies for colorectal cancer screening in China (TARGET-C): a study protocol for a multicentre randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e025935. Epub 2019 Apr 20.

Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Screening for colorectal cancer (CRC) is effective in reducing the disease burden. However, high-level evidence from randomised controlled trials on the effectiveness of CRC screening modalities is still lacking. We will conduct a large-scale multicentre randomised controlled trial in China to evaluate the effectiveness and cost-effectiveness of different CRC screening strategies. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025935DOI Listing

Prolapsing mass in the caecum: learning point for the colonoscopist.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Colorectal Surgery, Royal Gwent Hospital, Newport, UK.

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http://dx.doi.org/10.1136/bcr-2019-229811DOI Listing

Increased incidence of colon cancer among individuals younger than 50 years: A 17 years analysis from the cancer registry of the municipality of Milan, Italy.

Cancer Epidemiol 2019 Apr 18;60:134-140. Epub 2019 Apr 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda and Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.

Background: Colorectal cancer (CRC) overall incidence has been decreasing in the last decade. However, there is evidence of an increasing frequency of early-onset CRC in young individuals in several countries. The aim of this study is to evaluate the trends of CRC occurrence over 17 years in the municipality of Milan, Italy, focusing on early-onset CRC. Read More

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http://dx.doi.org/10.1016/j.canep.2019.03.015DOI Listing

Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience.

HPB (Oxford) 2019 Apr 17. Epub 2019 Apr 17.

University of Wisconsin, United States.

Background: Single institution reports demonstrate variable safety profiles when liver-directed therapy with Yttrium-90 (Y-90) is followed by hepatectomy. We hypothesized that in well-selected patients, hepatectomy after Y90 is feasible and safe.

Methods: Nine institutions contributed data for patients undergoing Y90 followed by hepatectomy (2008-2017). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.366DOI Listing

Clinical impact of peripherally inserted central catheters vs implanted port catheters in patients with cancer: an open-label, randomised, two-centre trial.

Br J Anaesth 2019 Apr 17. Epub 2019 Apr 17.

University of Linköping, Linköping, Sweden; Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, Linköping University Hospital, Linköping, Sweden.

Background: Centrally inserted totally implanted vascular access ports (PORTs) and peripherally inserted central catheters (PICCs) are widely used for the administration of chemotherapy. Our aim was to study the incidence of catheter-related deep venous thrombosis in patients with cancer receiving chemotherapy through either a PICC or a PORT.

Methods: Adults with non-haematological cancer (mainly breast and colorectal) from two Swedish oncology centres were included and followed for up to 1 yr. Read More

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http://dx.doi.org/10.1016/j.bja.2019.01.038DOI Listing

Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study.

Ecotoxicol Environ Saf 2019 Apr 17;178:168-177. Epub 2019 Apr 17.

Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Objectives: Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.

Methods: In this case-control study, 42 patients with CRC and 30 healthy subjects were selected. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.030DOI Listing

Predicting clinical outcomes of cirrhosis patients with hepatic encephalopathy from the fecal microbiome.

Cell Mol Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background & Aims: Gut dysbiosis plays a role in hepatic encephalopathy (HE), while its relationship at the acute episode of overt HE (AHE), the disease progression and clinical outcomes remains unclear. We aimed to identify AHE-specific microbiome and its association to patients' outcomes.

Methods: We profiled fecal microbiome changes for a cohort of 62 patients with cirrhosis and AHE i) before treatment, ii) 2-3 days after medication and iii) 2-3 months after recovery, and three control cohorts i) healthy individuals, patients with ii) compensated or iii) decompensated cirrhosis. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.008DOI Listing
April 2019
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BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study.

Gene 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Obesity is a major public health concern worldwide. Genetic, behavioral, and environmental factors contribute to the multifactorial etiology of obesity. Evidence suggests an association between human Brain-Derived Neurotrophic Factor (BDNF) Val66Met single nucleotide polymorphism (SNP) and obesity. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.045DOI Listing

LYRM2 directly Regulates Complex I Activity to Support Tumor Growth in Colorectal Cancer by Oxidative Phosphorylation.

Cancer Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou, 310009, China. Electronic address:

Oxidative phosphorylation (OXPHOS) in cancer has attracted a considerable attention in the past decades, and accumulated evidence has suggested that it plays an important role in tumor proliferation, metastasis and drug resistance. However, the mechanisms involved in these effects are still ambiguous to date. In this study, we found that LYR motif containing 2 (LYRM2), a novel molecule, is up-regulated in colorectal cancer and promotes tumor growth both in vivo and in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193025
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http://dx.doi.org/10.1016/j.canlet.2019.04.021DOI Listing
April 2019
1 Read

P300 Acetyltransferase is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in TGFβ-stimulated Hepatic Stellate Cells.

Hepatology 2019 Apr 20. Epub 2019 Apr 20.

Tumor Microenvironment and Metastasis, Hormel Institute, University of Minnesota, Austin, MN, USA.

Nuclear translocation of SMAD2/3, core transcription factors of TGFβ signaling, is critical for hepatic stellate cell (HSC) differentiation into metastasis-promoting myofibroblasts. SMAD2/3 have multiple coactivators, including WW domain-containing transcription regulator protein 1 (WWTR1 or TAZ) and p300 acetyltransferase. In the nucleus, TAZ binds to SMAD2/3 to prevent SMAD2/3 nuclear export. Read More

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http://dx.doi.org/10.1002/hep.30668DOI Listing

Colorectal cancer-associated ~6 kDa hyaluronan serves as a novel biomarker for cancer progression and metastasis.

FEBS J 2019 Apr 19. Epub 2019 Apr 19.

Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Low molecular weight hyaluronan (LMW-HA) is believed to accumulate in tumors and to exert pro-tumor effects. This study aimed to identify colorectal cancer (CRC)-associated LMW-HA, precisely determine its molecular weight and elucidate its role in predicting tumor progression. The molecular weight distribution of hyaluronan extracted from CRC and paired non-cancerous tissues was evaluated. Read More

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http://dx.doi.org/10.1111/febs.14859DOI Listing

ASO Author Reflections: Tending Towards a Personalized Medicine for Colorectal Carcinomatosis by Adding the RAS Mutation Status in the Workup for CRS and HIPEC.

Ann Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Oncologic and Pancreatic Surgery Unit, University Hospital Reina Sofıa, Córdoba, Spain.

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http://dx.doi.org/10.1245/s10434-019-07362-3DOI Listing

Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.

Purpose: Appendectomy has been the gold standard for every form of appendicitis. In recent years, though, it has repeatedly been claimed that for acute uncomplicated appendicitis, antibiotic therapy can be an equivalent treatment. The aim of this meta-analysis was to determine if antibiotic therapy is a safe and effective alternative to appendectomy for acute uncomplicated appendicitis. Read More

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http://link.springer.com/10.1007/s00384-019-03296-0
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http://dx.doi.org/10.1007/s00384-019-03296-0DOI Listing
April 2019
1 Read

A Clinical Applicable Gene Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Molecular Biology, Genentech Inc.

Purpose: Four consensus molecular subtypes (CMS1-4) of colorectal cancer (CRC) were identified in primary tumors and found to be associated with distinctive biological features and clinical outcomes. Given that distant metastasis largely accounts for CRC-related mortality, we examined the molecular and clinical attributes of CMS in metastatic CRC (mCRC).

Experimental Design: We developed a CRC-focused Nanostring based CMS classifier that is ideally suited to interrogate archival tissues. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3032DOI Listing
April 2019
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Circulating adipokines and risk of obesity related cancers: A systematic review and meta-analysis.

Obes Res Clin Pract 2019 Apr 16. Epub 2019 Apr 16.

Department of Family Medicine, Center for Obesity, Metabolism and Nutrition, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, South Korea. Electronic address:

Background: Obesity can influence on carcinogenesis through alterations in adipokines and subsequent inflammatory changes. This meta-analysis was aimed to comprehensively assess the association between circulating adipokines and risk of obesity-related cancers.

Methods: Pubmed and Embase were searched up to October 2017 for observational studies investigating the relationship between adipokines and cancers. Read More

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http://dx.doi.org/10.1016/j.orcp.2019.03.006DOI Listing
April 2019
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MEK and PD-L1 inhibition in colorectal cancer: a burning blaze turning into a flash in the pan.

Lancet Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gastrointestinal Unit, Department of Medical Oncology, Institut Jules Bordet, Brussels 1000, Belgium; Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045193007
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http://dx.doi.org/10.1016/S1470-2045(19)30076-2DOI Listing
April 2019
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Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial.

Lancet Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Electronic address:

Background: Microsatellite-stable metastatic colorectal cancer is typically unresponsive to immunotherapy. This phase 3 study was designed to assess atezolizumab plus cobimetinib in metastatic colorectal cancer. Here, we report the comparison of atezolizumab plus cobimetinib or atezolizumab monotherapy versus regorafenib in the third-line setting. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30027-0DOI Listing

Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Immunology, School of Life Sciences and Biopharmaceuticals Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Medical of State Administration of TCM, Guangzhou, 510006, PR China. Electronic address:

Background: Disulfiram (DSF), a drug widely used to control alcoholism, which has anticancer activity by inducing apoptosis in a copper (Cu)-dependent manner. Numerous evidences from mouse experiments indicated that some anti-cancer agents of chemotherapeutic drugs favor the induction of immunogenic cancer cell death (ICD) leading to tumor-specific immune responses. However, whether DSF could induce the colorectal tumor cells death and the mechanism involved in ICD regulatory remains elusive. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.192DOI Listing
April 2019
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Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Leiden University Medical Center, the Netherlands. Electronic address:

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.041DOI Listing

Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery.

Ultrasound Med Biol 2019 Apr 16. Epub 2019 Apr 16.

Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USA. Electronic address:

The gastrointestinal (GI) tract presents a notoriously difficult barrier for macromolecular drug delivery, especially for biologics. Herein, we demonstrate that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug. With ultrasound treatment in the presence of PCCAs, we achieved a maximum of 44 ± 15% transepithelial delivery of 70-kDa fluorescein isothiocyanate-dextran, compared with negligible delivery through sham control monolayers. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2019.02.004DOI Listing

Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial.

Complement Ther Clin Pract 2019 May 2;35:78-85. Epub 2019 Feb 2.

Department of Nursing, School of Nursing and Midwifery, Dezful University of Medical Sciences, Dezful, Iran. Electronic address:

Background And Purpose: Chemotherapy-induced phlebitis (CIP) is one of the most important and common complications in patients with cancer. Currently, the use of complementary methods to prevent or alleviate phlebitis symptoms has attracted great attention. In this study, we aimed to assess the effects of topical sesame oil in reducing the pain severity of CIP. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.01.016DOI Listing

Time to Follow-up After Colorectal Cancer Screening by Health Insurance Type.

Am J Prev Med 2019 May;56(5):e143-e152

Office of Disease Prevention, NIH, Bethesda, Maryland.

Introduction: The purpose of this study was to test the hypothesis that patients with Medicaid insurance or Medicaid-like coverage would have longer times to follow-up and be less likely to complete colonoscopy compared with patients with commercial insurance within the same healthcare systems.

Methods: A total of 35,009 patients aged 50-64years with a positive fecal immunochemical test were evaluated in Northern and Southern California Kaiser Permanente systems and in a North Texas safety-net system between 2011 and 2012. Kaplan-Meier estimation was used between 2016 and 2017 to calculate the probability of having follow-up colonoscopy by coverage type. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193003
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http://dx.doi.org/10.1016/j.amepre.2019.01.005DOI Listing
May 2019
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Flexicaulin A, An -Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.

Natural products, explicitly medicinal plants, are an important source of inspiration of antitumor drugs, because they contain astounding amounts of small molecules that possess diversifying chemical entities. For instance, (formerly ), a genus of the Lamiaceae (formerly Labiatae) family, has been reported as a rich source of natural diterpenes. In the current study, we evaluated the in vitro anti-proliferative property of flexicaulin A (FA), an diterpenoid with an -kaurane structure, in human carcinoma cells, by means of cell viability assay, flow cytometric assessment, quantitative polymerase chain reaction array, Western blotting analysis, and staining experiments. Read More

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https://www.mdpi.com/1422-0067/20/8/1917
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http://dx.doi.org/10.3390/ijms20081917DOI Listing
April 2019
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[Prophylactic hysterectomy in Lynch syndrome: feasibility and outcomes].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.04.010DOI Listing

Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer with a favorable toxicity profile. To move this formulation into clinical development, a formulation that is stable during long term storage is needed, which has similar pharmacokinetics and therapeutic activity against solid tumors to the original formulation. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.042DOI Listing

Abnormality of hepatic triglyceride metabolism in Apc mice with colon cancer cachexia.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, No.5333 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. Electronic address:

Aims: Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of Apc mice.

Main Methods: We measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and Apc mice. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.041DOI Listing

Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer.

Mol Cell 2019 Apr;74(2):227-229

Department of Immunology, University of Toronto, Toronto, ON M5B 1W8, Canada. Electronic address:

In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-producing bacteria in colon cancer pathogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193027
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http://dx.doi.org/10.1016/j.molcel.2019.04.007DOI Listing
April 2019
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Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer.

PLoS One 2019 19;14(4):e0215513. Epub 2019 Apr 19.

Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan.

Background: Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215513PLOS
April 2019
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Advanced Epithelial Ovarian Cancer: Do More Options Mean Greater Benefits?

J Clin Oncol 2019 Apr 19:JCO1900500. Epub 2019 Apr 19.

1 Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

A healthy 51-year-old woman presented with increasing abdominal and pelvic pain. Computed tomography imaging of the abdomen and pelvis showed an 11.6-cm pelvic mass, retroperitoneal lymphadenopathy, right hydronephrosis, and mesenteric tumor deposits ( Fig 1A ). Read More

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https://ascopubs.org/doi/10.1200/JCO.19.00500
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http://dx.doi.org/10.1200/JCO.19.00500DOI Listing
April 2019
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Overexpression of lncRNA TUSC7 reduces cell migration and invasion in colorectal cancer.

Oncol Rep 2019 Apr 9. Epub 2019 Apr 9.

Department of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai 200333, P.R. China.

Colorectal cancer (CRC) is a highly heterogeneous disease worldwide. Long non‑coding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) plays a crucial role in the development of several cancers. However, the role of TUSC7 in the tumorigenesis of CRC has not been explored. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7106
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http://dx.doi.org/10.3892/or.2019.7106DOI Listing
April 2019
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Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.

Oncol Rep 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

Colorectal cancer (CRC) is one of the most common tumor types of the digestive tract. Its incidence and mortality rates are among the highest of all gastrointestinal tumor types. The expression of leucine zipper downregulated in cancer 1 (LDOC1) is decreased in numerous cancer types. Read More

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http://dx.doi.org/10.3892/or.2019.7126DOI Listing

Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.

Oncol Rep 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Several studies have demonstrated that calpain‑1 is involved in a variety of pathophysiological processes, including tumorigenesis. However, the clinical relevance and role of calpain‑1 in colorectal cancer (CRC) are unclear. Filamin A (FLNA) is an actin‑binding protein that participates in cancer progression and can be cleaved by calpain‑1. Read More

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http://dx.doi.org/10.3892/or.2019.7121DOI Listing

Comparison of a Potential Hospital Quality Metric With Existing Metrics for Surgical Quality-Associated Readmission.

JAMA Netw Open 2019 Apr 5;2(4):e191313. Epub 2019 Apr 5.

Veterans Affairs, Palo Alto, Veterans Affairs Medical Center, Palo Alto, California.

Importance: The existing readmission quality metric does not meaningfully distinguish readmissions associated with surgical quality from those that are not associated with surgical quality and thus may not reflect the quality of surgical care.

Objective: To compare a quality metric that classifies readmissions associated with surgical quality with the existing metric of any unplanned readmission in a surgical population.

Design, Setting, And Participants: Cohort study using US nationwide administrative data collected on 4 high-volume surgical procedures performed at 103 Veterans Affairs hospitals from October 1, 2007, through September 30, 2014. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1313DOI Listing

Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3080-3087

Department of Gastroenterology, Zibo Central Hospital, Zibo, Shandong, China.

Objective: The phosphatase and tensin homologue deleted on chromosome ten (PTEN) acts as a tumor suppressor gene by inhibiting the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. DJ-1, a negative regulator of PTEN, is associated with the pathogenesis of a variety of tumors. Curcumin (Cur) is a phenolic compound that is extracted from various plant rhizomes with various anti-tumor pharmacological effects. Read More

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http://www.europeanreview.org/article/17591
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http://dx.doi.org/10.26355/eurrev_201904_17591DOI Listing
April 2019
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A systematic review of observational studies of trifluridine/tipiracil (TAS-102) for metastatic colorectal cancer.

Acta Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

e Department of Oncology , Zealand University Hospital , Roskilde , Denmark.

Background: The treatment options for patients with therapy refractory metastatic colorectal cancer (mCRC) are sparse. TAS-102 (FTD/TPI) is a new oral anti-tumour agent composed of a nucleoside analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil, indicated for patients with mCRC who are refractory to standard therapies. This study summarizes published and unpublished experience with FTD/TPI in clinical practice settings. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1605192DOI Listing

Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese.

Mol Carcinog 2019 Apr 18. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Genetic factors play important roles in colorectal carcinogenesis. This study was aimed to evaluate the effects of gene expression-related copy number variations (CNVs) on the risk of colorectal cancer in Chinese. Expression Quantitative Trait Locus (eQTL) mapping was conducted to explore the most regulatable gene expressions by CNVs among the whole genome based on publicly available data. Read More

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http://dx.doi.org/10.1002/mc.23015DOI Listing
April 2019
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The role of intestinal microbiota in the pathogenesis of colorectal carcinoma.

Folia Microbiol (Praha) 2019 Apr 18. Epub 2019 Apr 18.

Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Read More

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http://dx.doi.org/10.1007/s12223-019-00706-2DOI Listing
April 2019
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Tubing-Free Microfluidic Microtissue Culture System Featuring Gradual, -Like Substance Exposure Profiles.

Front Bioeng Biotechnol 2019 2;7:72. Epub 2019 Apr 2.

Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zürich, Zurich, Switzerland.

screening methods for compound efficacy and toxicity to date mostly include cell or tissue exposure to preset constant compound concentrations over a defined testing period. Such concentration profiles, however, do not represent realistic situations after substance uptake. Absorption, distribution, metabolism and excretion of administered substances in an organism or human body entail gradually changing pharmacokinetic concentration profiles. Read More

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00072
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http://dx.doi.org/10.3389/fbioe.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454105PMC
April 2019
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Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis.

Front Oncol 2019 2;9:216. Epub 2019 Apr 2.

Department of Tissue Engineering, Beijing Institute of Transfusion Medicine, Beijing, China.

Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells. In this study, we examined the expression of HPSE in different colorectal cancer (CRC) cell lines. Gene manipulation was applied to reveal the effect of HPSE on proliferation, invasion, and metastasis of CRC. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00216/
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http://dx.doi.org/10.3389/fonc.2019.00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454005PMC
April 2019
3 Reads

A Review on the Special Radiotherapy Techniques of Colorectal Cancer.

Front Oncol 2019 2;9:208. Epub 2019 Apr 2.

Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Colorectal cancer is one of the commonest cancers worldwide. Radiotherapy has been established as an indispensable component of treatment. Although conventional radiotherapy provides good local control, radiotherapy treatment side-effects, local recurrence and distant metastasis remain to be the concerns. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00208/
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http://dx.doi.org/10.3389/fonc.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454863PMC
April 2019
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A case of screening colonoscopy using linked-color imaging to detect ulcerative colitis-associated colorectal cancer.

Dig Liver Dis 2019 Apr 15. Epub 2019 Apr 15.

Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.

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http://dx.doi.org/10.1016/j.dld.2019.03.010DOI Listing

Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):119. Epub 2019 Apr 18.

geneXplain GmbH, 38302, Wolfenbüttel, Germany.

Background: The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promising approach to a noninvasive early diagnosis of CRC. Thousands of abnormally methylated CpG positions in CRC genomes are often located in non-coding parts of genes. Read More

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http://dx.doi.org/10.1186/s12859-019-2687-7DOI Listing

Validity and Reliability of Korean Version of Simplified Nutritional Appetite Questionnaire in Patients with Advanced Cancer: A Multicenter, Longitudinal Study.

Cancer Res Treat 2019 Apr 12. Epub 2019 Apr 12.

Division of Hematology and Oncology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Purpose: Malnutrition and a loss of muscle mass are frequent in cancer patients and have a negative effect on clinical outcome. Nutrition risk screening aims to increase awareness and allow early recognition and treatment of cancer cachexia. Therefore, screenings should be brief, inexpensive, highly sensitive, and have good specificity. Read More

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http://dx.doi.org/10.4143/crt.2018.505DOI Listing

Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Bioneer A/S, Hørsholm, Kogle Allé 2, 2970 Hørsholm, Denmark.

MicroRNA-21 (miR-21) is upregulated in many cancers including colon cancers and is a prognostic indicator of recurrence and poor prognosis. In colon cancers, miR-21 is highly expressed in stromal fibroblastic cells and more weakly in a subset of cancer cells, particularly budding cancer cells. Exploration of the expression of inflammatory markers in colon cancers revealed tumor necrosis factor alpha (TNF-α) mRNA expression at the invasive front of colon cancers. Read More

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http://dx.doi.org/10.3390/ijms20081907DOI Listing

Timing of Adjuvant Chemotherapy and Survival in Colorectal, Gastric, and Pancreatic Cancer. A Systematic Review and Meta-Analysis.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Oncology Unit, ASST Cremona, 26100 Cremona, Italy.

(1) Background: The optimal timing of adjuvant chemotherapy (CT) in gastrointestinal malignancies is still a matter of debate. For colorectal cancer, it is recommended to start post-operative treatment within eight weeks. The objective of this study was to assess the clinical effects of starting adjuvant CT within or after 6-8 weeks post-surgery in colorectal, gastric, and pancreatic cancer. Read More

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https://www.mdpi.com/2072-6694/11/4/550
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http://dx.doi.org/10.3390/cancers11040550DOI Listing
April 2019
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Extreme value analysis of gut microbial alterations in colorectal cancer.

Phys Rev E 2019 Mar;99(3-1):032413

Microbiome Program, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

Gut microbes play a key role in colorectal carcinogenesis, yet reaching a consensus on microbial signatures remains a challenge. This is in part due to a reliance on mean value estimates. We present an extreme value analysis for overcoming these limitations. Read More

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https://link.aps.org/doi/10.1103/PhysRevE.99.032413
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http://dx.doi.org/10.1103/PhysRevE.99.032413DOI Listing
March 2019
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Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Naïve Patients with Liver Metastases from Colorectal Cancer.

Oncology 2019 Apr 18. Epub 2019 Apr 18.

Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.

Background: In case of response to chemotherapy, unresectable liver metastases from colorectal cancer can be converted to resectable and thereby obtain a chance of cure. The primary aim of this trial was to evaluate the response rate with intrahepatic oxaliplatin in combination with systemic 5-FU +/- cetuximab. Secondary aims were to evaluate the conversion rate from unresectable to resectable liver metastases, median progression-free survival, median overall survival, and toxicity. Read More

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http://dx.doi.org/10.1159/000499314DOI Listing
April 2019
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Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs.

Obes Facts 2019 Apr 18;12(2):211-225. Epub 2019 Apr 18.

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Increasing prevalence of obesity requires the investigation of respective comorbidities, including tumor diseases like colorectal, renal, post-menopausal breast, prostate cancer, and leukemia. To date, molecular mechanisms of the malignant transformation of these peripheral tissues induced by obesity remain unclear. Adipose tissue secretes factors with hormone-like functions, the adipokines, and is therefore categorized as an endocrine organ. Read More

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https://www.karger.com/Article/FullText/496625
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http://dx.doi.org/10.1159/000496625DOI Listing
April 2019
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Diagnostic accuracy of hematological parameters in Acute mesenteric ischemic-A systematic Review.

Int J Surg 2019 Apr 15. Epub 2019 Apr 15.

Sir Syed College of Medical Sciences for Girls, Karachi, Pakistan.

Background: We conducted a systematic review on the diagnostic accuracy of classical and newly reported hematological parameters which are easily available in a resource limited setting in making a diagnosis of Acute Mesenteric Ischemia (AMI).

Methods: We searched the PubMed, Scopus, and Cochrane library from January 1940 to April 2018. The search was limited to studies published in English and those involving human subjects only. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17439191193008
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http://dx.doi.org/10.1016/j.ijsu.2019.04.005DOI Listing
April 2019
4 Reads