157,594 results match your criteria Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland[Journal]


Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer.

Oncology 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Pharmacy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Purpose: Hand-foot skin reaction (HFSR) can deteriorate quality of life in patients receiving regorafenib. Cutaneous toxicity is a main adverse effect of multikinase inhibitors and has also been associated with clinical outcome. This study assessed the association between the antitumor efficacy of regorafenib and HFSR in patients with metastatic colorectal cancer (mCRC). Read More

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http://dx.doi.org/10.1159/000495989DOI Listing
February 2019

Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.

Digestion 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aims: Runt-related transcription factor (RUNX) 3 is a tumor suppressor whose expression is reduced in non-neoplastic rectal mucosa of patients with ulcerative colitis (UC) with coexisting colitis-associated cancer (CAC). We aimed to evaluate RUNX3 utility as a predictive marker for CAC using immunohistochemistry (IHC) for non-neoplastic UC mucosa.

Methods: We retrospectively compared the RUNX3 expression detected by IHC between non-neoplastic rectal biopsy specimens from 20 cases with invasive cancer (CAC group) and 20 cases selected from 138 patients without CAC (non-CAC group) that were treated during the same period (2006-2017) and were matched for sex, duration, extension, and age. Read More

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http://dx.doi.org/10.1159/000497272DOI Listing
February 2019

Colonic adenoma-associated Escherichia coli express specific phenotypes.

Microbes Infect 2019 Feb 11. Epub 2019 Feb 11.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy; Dani Di Giò Foundation-Onlus, Rome, Italy. Electronic address:

Specific Escherichia coli strains have been associated to colorectal cancer, while no data are available on genotypic and phenotypic features of E. coli colonizing premalignant adenomatous polyps and their pathogenic potential. This study was aimed at characterizing isolates collected from polyps and adjacent tissue in comparison with those from normal mucosa. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.02.001DOI Listing
February 2019

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS One 2019 14;14(2):e0211916. Epub 2019 Feb 14.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211916PLOS
February 2019

Complex harmonic regularization with differential evolution in a memetic framework for biomarker selection.

PLoS One 2019 14;14(2):e0210786. Epub 2019 Feb 14.

Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau.

For studying cancer and genetic diseases, the issue of identifying high correlation genes from high-dimensional data is an important problem. It is a great challenge to select relevant biomarkers from gene expression data that contains some important correlation structures, and some of the genes can be divided into different groups with a common biological function, chromosomal location or regulation. In this paper, we propose a penalized accelerated failure time model CHR-DE using a non-convex regularization (local search) with differential evolution (global search) in a wrapper-embedded memetic framework. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210786PLOS
February 2019

Predictors of Readmission Following Proctectomy for Rectal Cancer.

Dis Colon Rectum 2019 Feb 8. Epub 2019 Feb 8.

Department of Colorectal Surgery, Beaumont Hospital, Dublin, Ireland.

Background: Unplanned readmission after surgery negatively impacts surgical recovery. Few studies have sought to define predictors of readmission in a rectal cancer cohort alone. Readmission following rectal cancer surgery may be reduced by the identification and modification of factors associated with readmission. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001355DOI Listing
February 2019

Immersive Virtual Colonoscopy.

IEEE Trans Vis Comput Graph 2019 Feb 14. Epub 2019 Feb 14.

Virtual colonoscopy (VC) is a non-invasive screening tool for colorectal polyps which employs volume visualization of a colon model reconstructed from a CT scan of the patient's abdomen. We present an immersive analytics system for VC which enhances and improves the traditional desktop VC through the use of VR technologies. Our system, using a head-mounted display (HMD), includes all of the standard VC features, such as the volume rendered endoluminal fly-through, measurement tool, bookmark modes, electronic biopsy, and slice views. Read More

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http://dx.doi.org/10.1109/TVCG.2019.2898763DOI Listing
February 2019

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Department of General Surgery, The Second People's Hospital of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, P.R.China.

In this study, microarray data analysis, real-time quantitative PCR and immunohistochemistry were used to detect the expression levels of SSRP1 in colorectal cancer (CRC) tissue and in corresponding normal tissue. The association between structure-specific recognition protein 1 (SSRP1) expression and patient prognosis was examined by Kaplan-Meier analysis. SSRP1 was knocked down and overexpressed in CRC cell lines, and its effects on proliferation, cell cycling, migration, invasion, cellular energy metabolism, apoptosis, chemotherapeutic drug sensitivity and cell phenotype-related molecules were assessed. Read More

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http://dx.doi.org/10.1111/jcmm.14134DOI Listing
February 2019

Recommendations for follow-up of colorectal cancer survivors.

Clin Transl Oncol 2019 Feb 14. Epub 2019 Feb 14.

Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Colorectal cancer (CRC) is one of the tumours with the highest incidence and mortality in the Spanish population. Nevertheless, the advances in prevention and treatment have contributed to an increased number of patients who survive for prolonged periods of time. In addition, despite recurrences, improved survival following metastasis resection is likewise on the rise. Read More

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http://dx.doi.org/10.1007/s12094-019-02059-1DOI Listing
February 2019

Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer.

Virchows Arch 2019 Feb 14. Epub 2019 Feb 14.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Metastatic lung cancers from the colon and rectum (MLCR) frequently have necrotic components. The aim of this study is to elucidate clinicopathological factors associated with the amount of necrosis in MLCR. Ninety patients who underwent the first pulmonary metastasectomy for MLCR with a tumor diameter ≦ 3. Read More

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http://dx.doi.org/10.1007/s00428-019-02535-7DOI Listing
February 2019

Appendicectomy in older patients with acute appendicitis is not an indication for routine colonoscopy.

Int J Colorectal Dis 2019 Feb 14. Epub 2019 Feb 14.

Department of Accident and Emergency, St Helens and Knowsley Hospitals NHS Trust, Prescot, UK.

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http://dx.doi.org/10.1007/s00384-019-03264-8DOI Listing
February 2019

External validation of anastomotic leakage risk analysis system in patients who underwent colorectal resection

Turk J Med Sci 2019 Feb 11;49(1):279-282. Epub 2019 Feb 11.

Background/aim: One of the most feared complications after colon resection for carcinoma is anastomotic leakage. Prediction of anastomotic leakage can alter pre- and perioperative management of patients. This study validates an anastomotic leakage prediction system. Read More

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http://dx.doi.org/10.3906/sag-1807-205DOI Listing
February 2019

Interdependence between an expression of the gene and the gene in colorectal cancer.

J Biol Regul Homeost Agents 2019 Feb 14;33(1). Epub 2019 Feb 14.

Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.

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February 2019

Outcomes of laparoscopic surgery for pT3/pT4 colorectal cancer in young vs. old patients.

Minerva Chir 2019 Feb 13. Epub 2019 Feb 13.

Department of General Surgery, University Hospital of Trieste, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.

Background: Laparoscopy for locally advanced colorectal cancer is not standardized yet and its potential risks and benefits in elderly patients are still under debate. The aim of this study was to evaluate clinical and oncologic results of laparoscopic surgery for pT3/pT4 lesions in both old and young people.

Methods: Between 2006 and 2015, 115 patients aged <70 years and 112 patients aged ≥70 years underwent elective laparoscopic surgery for pT3/pT4 colorectal cancer presenting without distant metastasis at the Department of General Surgery, Trieste. Read More

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http://dx.doi.org/10.23736/S0026-4733.19.07895-7DOI Listing
February 2019

Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival.

Asia Pac J Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Footscray Hospital, Western Health, Footscray, Victoria, Australia.

Background: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute.

Methods: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. Read More

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http://dx.doi.org/10.1111/ajco.13135DOI Listing
February 2019

Emotional functioning to screen for psychological distress in breast and colorectal cancer patients prior to adjuvant treatment initiation.

Eur J Cancer Care (Engl) 2019 Feb 13:e13005. Epub 2019 Feb 13.

Department of Medical Oncology. Hospital, Universitario Central de Asturias, Oviedo, Spain.

Introduction: The objective was to analyze the usefulness of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) EF subscale to detect emotional problems in patients with breast (BC) and colorectal cancer (CRC).

Methods: A prospective, observational, cross-sectional study was conducted. Participants completed the Brief Symptom Inventory (BSI) and EORTC-QLQ-C30. Read More

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http://dx.doi.org/10.1111/ecc.13005DOI Listing
February 2019

Optimized light delivery probe using ball lenses for co-registered photoacoustic and ultrasound endo-cavity subsurface imaging.

Photoacoustics 2019 Mar 7;13:66-75. Epub 2018 Dec 7.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

An optimized hand-held photoacoustic and ultrasound probe suitable for endo-cavity tumor subsurface imaging was designed and evaluated. Compared to previous designs, the prototype probe, consisting of four 1 mm multi-mode optical fibers attached with 1.5 mm diameter ball-shaped fiber tips sandwiched between a transvaginal ultrasound transducer and a custom-made sheath, demonstrated a higher light output and better beam homogeneity on tissue subsurface. Read More

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http://dx.doi.org/10.1016/j.pacs.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304457PMC

deepDriver: Predicting Cancer Driver Genes Based on Somatic Mutations Using Deep Convolutional Neural Networks.

Front Genet 2019 29;10:13. Epub 2019 Jan 29.

Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.

With the advances in high-throughput technologies, millions of somatic mutations have been reported in the past decade. Identifying driver genes with oncogenic mutations from these data is a critical and challenging problem. Many computational methods have been proposed to predict driver genes. Read More

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http://dx.doi.org/10.3389/fgene.2019.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361806PMC
January 2019

LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.

Front Immunol 2019 29;10. Epub 2019 Jan 29.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.

Layilin (LAYN) is a critical gene that regulates T cell function. However, the correlations of LAYN to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. LAYN expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362421PMC
January 2019

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

Nat Commun 2019 Feb 13;10(1):724. Epub 2019 Feb 13.

MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (Apc), or by Apc encoding a partially-functional Apc truncation commonly found in colorectal carcinomas. Read More

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http://dx.doi.org/10.1038/s41467-018-08164-zDOI Listing
February 2019

Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.

Cell Death Dis 2019 Feb 13;10(2):143. Epub 2019 Feb 13.

LIM 64, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Protein disulfide isomerases including PDIA1 are implicated in cancer progression, but underlying mechanisms are unclear. PDIA1 is known to support vascular Nox1 NADPH oxidase expression/activation. Since deregulated reactive oxygen species (ROS) production underlies tumor growth, we proposed that PDIA1 is an upstream regulator of tumor-associated ROS. Read More

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http://dx.doi.org/10.1038/s41419-019-1402-yDOI Listing
February 2019

STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells.

Biosci Rep 2019 Feb 13. Epub 2019 Feb 13.

Affiliated Hospital of Yan'an University, Yan'an, 716000, China

Serine/threonine kinase 33 (STK33) is a serine/threonine kinase, and participates in many apoptotic process. Herein, we found that the extracellular signal-regulated kinase 2 (ERK2) was a substrate of STK33. STK33 phosphorylated ERK2and increased the activity of ERK2 and promote the tumorigenesis of colorectal cancer HCT15 cells. Read More

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http://dx.doi.org/10.1042/BSR20182351DOI Listing
February 2019

Staff experiences of enhanced recovery after surgery: systematic review of qualitative studies.

BMJ Open 2019 Feb 12;9(2):e022259. Epub 2019 Feb 12.

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: To conduct a systematic review of qualitative studies which explore health professionals' experiences of and perspectives on the enhanced recovery after surgery (ERAS) pathway.

Design: Systematic review of qualitative literature using a qualitative content analysis. Literature includes the experiences and views of a wide range of multidisciplinary team and allied health professional staff, to incorporate a diverse range of clinical and professional perspectives. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022259DOI Listing
February 2019

Calcium intake and risk of colorectal cancer according to tumor infiltrating T cells.

Cancer Prev Res (Phila) 2019 Feb 13. Epub 2019 Feb 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School

Calcium intake has been associated with a lower risk of colorectal cancer. Calcium signaling may enhance T cell proliferation and differentiation, and contribute to T-cell mediated antitumor immunity. In this prospective cohort study, we investigated the association between calcium intake and colorectal cancer risk according to tumor immunity status to provide additional insights into the role of calcium in colorectal carcinogenesis. Read More

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0279DOI Listing
February 2019
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Cytoreductive surgery and heated intraperitoneal chemotherapy for peritoneal carcinomatosis from rare etiologies.

Am J Surg 2019 Jan 25. Epub 2019 Jan 25.

Department of Surgery and Oncology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) are commonly used in the treatment of peritoneal carcinomatosis (PC) originating from colorectal, appendiceal and ovarian cancers. It is unclear what benefit CRS/HIPEC might have for PC from uncommon etiologies, therefore we sought to describe local practice patterns and evaluate overall survival (OS).

Methods: All patients who had CRS/HIPEC between 2000 and 2016 were identified using our institutional cancer database. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.01.011DOI Listing
January 2019

Barriers to Colonoscopy in an Uninsured Patient Population-A Quality Improvement Project.

Am Surg 2019 Jan;85(1):111-114

Colorectal cancer remains common, with the "80 per cent by 2018" initiative proposed by the National Colorectal Cancer Roundtable. This study was designed to examine obstacles for patients who did not receive their scheduled colonoscopy, focusing on the impact of insurance status. Retrospective chart review was carried out on patients who did not complete their colonoscopy as scheduled from January 2013 to June 2017. Read More

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January 2019

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

Lab Anim 2019 Feb 13:23677219826165. Epub 2019 Feb 13.

2 Department of Molecular and Clinical Pharmacology, University of Liverpool, UK.

Improving outcomes in colorectal cancer requires more accurate in vivo modelling of the disease in humans, allowing more reliable pre-clinical assessment of potential therapies. Novel imaging techniques are necessary to improve the longitudinal assessment of disease burden in these models, reducing the number of animals required for translational studies. This report describes the development of an immune-competent syngeneic orthotopic murine model of colorectal cancer, utilising caecal implantation of CT26 cells stably transfected with the luciferase gene into immune-competent BALB/c mice, allowing serial bioluminescent imaging of cancer progression. Read More

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http://dx.doi.org/10.1177/0023677219826165DOI Listing
February 2019

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Radiopharmaceutical Chemistry Unit, Oncologic and High Technologies Department, Azienda USL-IRCCS, via Amendola 2, 42122 Reggio Emilia, Italy.

Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 have demonstrated preferential uptake in HT29 colorectal cancer and K562 lymphoma cell lines compared to normal human lymphocytes. In the present study, we report a new gallium-68-labelled curcumin derivative (Ga-DOTA-C21) and its initial validation as marker for early detection of colorectal cancer. Read More

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http://dx.doi.org/10.3390/molecules24030644DOI Listing
February 2019

The Development of a Liver Abscess after Screening Colonoscopy: A Calculated Risk?

Eur J Case Rep Intern Med 2017 4;4(7):000650. Epub 2017 Jul 4.

Department of Gastroenterology, Gelderse Vallei Hospital, Ede, The Netherlands.

We present the case of a patient who developed a liver abscess following screening colonoscopy. A colorectal screening program was introduced in the Netherlands in 2014 in order to reduce mortality from colorectal cancer. The patient in this report, a 63-year-old man with no significant medical history, underwent polypectomy of two polyps. Read More

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http://dx.doi.org/10.12890/2017_000650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346913PMC

Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence.

Clin Chem Lab Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Cellular Physiology, G. Papanicolaou Research Center of Oncology, "Saint Savvas" Cancer Hospital of Athens, Athens, Greece.

Background Kallikrein-related peptidases (KLKs) are a subgroup of serine proteases located on chromosome 19q13.3. Most KLKs have been extensively studied as potential biomarkers for several carcinomas and other diseases. Read More

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http://dx.doi.org/10.1515/cclm-2018-1010DOI Listing
February 2019
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Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes.

Elife 2019 Feb 13;8. Epub 2019 Feb 13.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.

Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colorectal cancer (CRC). Analysis of a genetically-diverse cohort of CRC specimens revealed that microsatellite instable (MSI) samples have a high indel rate within active enhancers. Read More

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http://dx.doi.org/10.7554/eLife.40760DOI Listing
February 2019

First-line therapy for metastatic colorectal cancer: Current perspectives and future directions.

Asia Pac J Clin Oncol 2019 Feb;15 Suppl 1:3-14

Department of Cancer Care Services, Royal Brisbane Hospital, University Of Queensland, Herston, Queensland.

The prognosis for patients with newly diagnosed inoperable metastatic colorectal cancer has steadily improved over the past two decades as new agents have been introduced into clinical practice and many new biomarkers have been discovered. In parallel with this progress, clinicians face increasingly complex treatment decisions. This review summarizes recent progress, with a historical perspective, which should help guide the clinician in decision making and optimal therapy selection. Read More

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http://dx.doi.org/10.1111/ajco.13119DOI Listing
February 2019

[Influence of tumor-free resection margins on overall and disease-free survival after resection of colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0899-zDOI Listing
February 2019

[Inflammatory markers in the identification of septic complications in colorectal surgery : Results of the IMACORS study].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie, Universitätsklinik Würzburg, 97080, Würzburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0821-8DOI Listing
February 2019

[Prognostic importance of resection margins in multiple colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0864-xDOI Listing
February 2019

[Liver resection for colorectal metastases in elderly patients].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, 07747, Am Klinikum 1, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0847-yDOI Listing
February 2019

[Laparoscopic vs. open resection of colorectal liver metastases].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0879-3DOI Listing
February 2019

[Unresectable colorectal liver metastases : Prolonged survival with aggressive local therapy].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0854-zDOI Listing
February 2019

ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN'S DISEASE IN A SINGLE CENTER.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1420. Epub 2019 Feb 7.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value.

Aim: To explore the clinical characteristics of perianal fistulising CD.

Methods: Analysis of 139 cases focused on their clinical data. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1420DOI Listing
February 2019

IMPLEMENTATION OF ENHANCED RECOVERY AFTER COLORECTAL SURGERY (ERAS) PROTOCOL: INITIAL RESULTS OF THE FIRST BRAZILIAN EXPERIENCE.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1419. Epub 2019 Feb 7.

Anesthesiology Service.

Background: Guidelines for enhanced recovery after surgery have their bases in colonic surgery, through the first protocols published in 2012. Since then, this practice has spread throughout the world, mainly due to improvements in surgical outcomes associated with resource savings.

Aim: To analyze the first prospective results after the implementation of the guidelines. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1419DOI Listing
February 2019

Monopolar Electrosurgical Scissors Versus Harmonic Scalpel in Robotic Anterior Resection of Rectal Cancer: A Retrospective Cohort Study.

J Laparoendosc Adv Surg Tech A 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.

Background: Robot-assisted surgical techniques have been introduced in recent years as an alternative minimally invasive approach for colorectal surgery. In practice, we found that the monopolar electrosurgical scissors had its unique advantages in preservation of the pelvic autonomic nerves. We performed a retrospective review of short-term results between using monopolar electrosurgical scissors and harmonic scalpel in robotic anterior resection (using the da Vinci Surgical System) in rectal cancer patients. Read More

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http://dx.doi.org/10.1089/lap.2018.0740DOI Listing
February 2019

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019

Aspirin ameliorates lung cancer by targeting the miR-98/WNT1 axis.

Thorac Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Tumor Department of Hematology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Aspirin, an anti-inflammatory drug, has been widely investigated in the treatment of many cancer types, including colorectal, ovarian, breast, and prostate cancers. MicroRNAs (miRNAs) are the most well studied noncoding RNAs in cancers. In the current study, we were interested in defining the function of aspirin in lung cancer treatment and the related noncoding RNAs involved in this process. Read More

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http://dx.doi.org/10.1111/1759-7714.12992DOI Listing
February 2019

Fulminant amoebic colitis and septic shock in a returning traveller.

ANZ J Surg 2019 Jan;89(1-2):E50

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/ans.14975DOI Listing
January 2019

Systematic Review with Meta-Analysis: Chromoendoscopy versus White Light Endoscopy in Detection of Dysplasia in Patients with Inflammatory Bowel Disease.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Aim: To compare chromoendoscopy (CE) and white light endoscopy (WLE) for dysplasia surveillance in inflammatory bowel disease (IBD) patients.

Methods: We conducted a meta-analysis of six RCTs and five prospective studies and performed a comparison between CE and WLE groups. Fixed-effect model was used unless heterogeneity was high. Read More

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http://dx.doi.org/10.1111/1751-2980.12714DOI Listing
February 2019

Safety of laparoscopic appendicectomy during pregnancy: a systematic review and meta-analysis.

ANZ J Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Colorectal Surgery, Division of Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Background: Acute appendicitis is the most common non-obstetric surgical presentation during pregnancy. There were concerns that laparoscopic appendicectomy increases the risk of foetal loss compared to an open approach. Therefore, with recent advances in perioperative care, it is likely the risk has changed. Read More

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http://dx.doi.org/10.1111/ans.14963DOI Listing
February 2019

Integrated analysis of competing endogenous RNA networks revealing five prognostic biomarkers associated with colorectal cancer.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Biotherapy, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Colorectal cancer (CRC) is a common malignant tumor with high morbidity and mortality around the world. The aim of this study was to determine the genes significantly associated with the overall survival (OS) of CRC patients and predict their function in the competing endogenous RNA (ceRNA) regulation networks. We constructed the lncRNA-miRNA-mRNA networks according to the differentially expressed RNAs from the The Cancer Genome Atlas data sets of 561 CRC patients. Read More

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http://dx.doi.org/10.1002/jcb.28403DOI Listing
February 2019

Perceptions of Cancer Causes, Prevention, and Treatment Among Navajo Cancer Survivors.

J Cancer Educ 2019 Feb 12. Epub 2019 Feb 12.

College of Health and Human Services, Northern Arizona University, Flagstaff, AZ, USA.

Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. Read More

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http://dx.doi.org/10.1007/s13187-019-01487-5DOI Listing
February 2019