220,324 results match your criteria Colorectal Tumors


Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Authors:
Valentina Silvestri Goska Leslie Daniel R Barnes Bjarni A Agnarsson Kristiina Aittomäki Elisa Alducci Irene L Andrulis Rosa B Barkardottir Alicia Barroso Daniel Barrowdale Javier Benitez Bernardo Bonanni Ake Borg Saundra S Buys Trinidad Caldés Maria A Caligo Carlo Capalbo Ian Campbell Wendy K Chung Kathleen B M Claes Sarah V Colonna Laura Cortesi Fergus J Couch Miguel de la Hoya Orland Diez Yuan Chun Ding Susan Domchek Douglas F Easton Bent Ejlertsen Christoph Engel D Gareth Evans Lidia Feliubadalò Lenka Foretova Florentia Fostira Lajos Géczi Anne-Marie Gerdes Gord Glendon Andrew K Godwin David E Goldgar Eric Hahnen Frans B L Hogervorst John L Hopper Peter J Hulick Claudine Isaacs Angel Izquierdo Paul A James Ramunas Janavicius Uffe Birk Jensen Esther M John Vijai Joseph Irene Konstantopoulou Allison W Kurian Ava Kwong Elisabetta Landucci Fabienne Lesueur Jennifer T Loud Eva Machackova Phuong L Mai Keivan Majidzadeh-A Siranoush Manoukian Marco Montagna Lidia Moserle Anna Marie Mulligan Katherine L Nathanson Heli Nevanlinna Joanne Ngeow Yuen Ye Liene Nikitina-Zake Kenneth Offit Edith Olah Olufunmilayo I Olopade Ana Osorio Laura Papi Sue K Park Inge Sokilde Pedersen Pedro Perez-Segura Annabeth H Petersen Pedro Pinto Berardino Porfirio Miquel Angel Pujana Paolo Radice Johanna Rantala Muhammad U Rashid Barak Rosenzweig Maria Rossing Marta Santamariña Rita K Schmutzler Leigha Senter Jacques Simard Christian F Singer Angela R Solano Melissa C Southey Linda Steele Zoe Steinsnyder Dominique Stoppa-Lyonnet Yen Yen Tan Manuel R Teixeira Soo H Teo Mary Beth Terry Mads Thomassen Amanda E Toland Sara Torres-Esquius Nadine Tung Christi J van Asperen Ana Vega Alessandra Viel Jeroen Vierstraete Barbara Wappenschmidt Jeffrey N Weitzel Greet Wieme Sook-Yee Yoon Kristin K Zorn Lesley McGuffog Michael T Parsons Ute Hamann Mark H Greene Judy A Kirk Susan L Neuhausen Timothy R Rebbeck Marc Tischkowitz Georgia Chenevix-Trench Antonis C Antoniou Eitan Friedman Laura Ottini

JAMA Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Importance: The limited data on cancer phenotypes in men with germline BRCA1 and BRCA2 pathogenic variants (PVs) have hampered the development of evidence-based recommendations for early cancer detection and risk reduction in this population.

Objective: To compare the cancer spectrum and frequencies between male BRCA1 and BRCA2 PV carriers.

Design, Setting, And Participants: Retrospective cohort study of 6902 men, including 3651 BRCA1 and 3251 BRCA2 PV carriers, older than 18 years recruited from cancer genetics clinics from 1966 to 2017 by 53 study groups in 33 countries worldwide collaborating through the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.2134DOI Listing

Systematic review and meta-analysis of diet quality and colorectal cancer risk: is the evidence of sufficient quality to develop recommendations?

Crit Rev Food Sci Nutr 2020 Jul 2:1-10. Epub 2020 Jul 2.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The quality of existing evidence about the impact of diet quality on colorectal cancer (CRC) risk has only rarely been assessed. In the current review, we searched PubMed, EMBASE, Web of Science, Cochrane, and the resulting references (up to January 2020) for studies that evaluated the role of high diet quality by extreme dietary index categorization and the risk of CRC. Two researchers independently performed the study selection, data extraction, and quality assessment. Read More

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http://dx.doi.org/10.1080/10408398.2020.1786353DOI Listing

Quality of same-day CT colonography following incomplete optical colonoscopy.

Eur Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

Objectives: Same-day CT colonography (CTC) following incomplete optical colonoscopy allows patients to avoid both a delayed diagnosis and the need for repeat bowel preparation. The aim of our study is to establish the diagnostic quality of same-day CT colonography following an incomplete optical colonoscopy.

Methods: We performed a retrospective review of patients undergoing same-day CT colonography following an incomplete colonoscopy at our center between July 2015 and December 2017 (N = 245). Read More

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http://dx.doi.org/10.1007/s00330-020-06979-3DOI Listing

Appendiceal diverticulosis in a patient with family history of Birt-Hogg-Dubé syndrome--a case report.

Radiol Case Rep 2020 Aug 24;15(8):1317-1322. Epub 2020 Jun 24.

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri- Columbia, One Hospital Drive, Columbia, MO, 65212, USA.

Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder that predisposes patients to cutaneous tumors, pulmonary cysts with recurrent spontaneous pneumothoraces, and a variety of renal neoplasms including hybrid oncocytic and chromophobe renal cell carcinomas. There has been much debate regarding the genetic link with the occurrence of colorectal cancer and other colonic anomalies. Associations between BHD and intestinal adenomatous polyposis and sigmoid diverticulosis have been described in the literature, but there have been no prior reports of appendiceal diverticulosis in patients with BHD. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322125PMC

Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.

Sci Rep 2020 Jul 1;10(1):10725. Epub 2020 Jul 1.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.

Metastasis is the primary cause of cancer mortality. The primary tumors of colorectal cancer (CRC) often metastasize to the liver. In this study, we have collected 122 samples from 45 CRC patients. Read More

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http://dx.doi.org/10.1038/s41598-020-67842-5DOI Listing

Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer.

World J Surg Oncol 2020 Jul 1;18(1):149. Epub 2020 Jul 1.

Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.

Aim: The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomiasis on colorectal cancer (CRC) patients' clinical outcomes.

Methods: Three hundred fifty-one cases of CRC were retrospectively analyzed in this study. Survival curves were constructed by using the Kaplan-Meier (K-M) method. Read More

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http://dx.doi.org/10.1186/s12957-020-01925-5DOI Listing

Patient-reported and doctor-reported symptoms when faecal immunochemical tests are requested in primary care in the diagnosis of colorectal cancer and inflammatory bowel disease: a prospective study.

BMC Fam Pract 2020 Jul 1;21(1):129. Epub 2020 Jul 1.

Department of Public Health and Clinical Medicine, Unit of Research, Education and Development - Östersund, Östersund Hospital, Umeå University, Umeå, Sweden.

Background: Rectal bleeding and a change in bowel habits are considered to be alarm symptoms for colorectal cancer and they are also common symptoms for inflammatory bowel disease. However, most patients with these symptoms do not have any of these diseases. Faecal immunochemical tests (FITs) for haemoglobin are used as triage tests in Sweden and other countries but little is known about the symptoms patients have when FITs are requested. Read More

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http://dx.doi.org/10.1186/s12875-020-01194-xDOI Listing

Promoter Hypermethylation of Wnt/β-catenin Signaling Pathway Inhibitor Gene and its Association with MTHFR C677T Polymorphism in Patients with Colorectal Cancer.

Oman Med J 2020 May 25;35(3):e131. Epub 2020 Jun 25.

Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.

Objectives: Colorectal cancer (CRC) is a common malignancy with a high rate of mortality. The dysregulation of genes involved in the Wnt/β-catenin signaling pathway is a common finding in cancers. Wnt-inhibitory factor-1 () suppresses the Wnt/β-catenin signaling pathway and its inactivation by genetics and epigenetic changes may cause cancer. Read More

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http://dx.doi.org/10.5001/omj.2020.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315525PMC

Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade.

Cancer Manag Res 2020 24;12:4937-4948. Epub 2020 Jun 24.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China.

Background: Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good anti-tumor activity against a variety of solid tumors. However, its effect on colorectal cancer (CRC) is not yet clearly understood. The objective of this study was to investigate the anti-tumor effect and underlying mechanism of anlotinib in the pathogenesis of CRC. Read More

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http://dx.doi.org/10.2147/CMAR.S252181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321688PMC

Knockdown of lncRNA HCP5 Suppresses the Progression of Colorectal Cancer by miR-299-3p/PFN1/AKT Axis.

Cancer Manag Res 2020 19;12:4747-4758. Epub 2020 Jun 19.

Department of Laboratory Medicine, The Affiliated Xi'an Centre Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710003, People's Republic of China.

Background: Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system. The lncRNA HCP5 has been reported to affect the progression of tumor in several types of cancer. Here, in this research, we focus on the role and function of lncRNA HCP5 in human colorectal cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S255866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310975PMC

Upregulated SET Promotes Cell Survival Through Activating Akt/NF-κB Signal in Colorectal Carcinoma.

Cancer Manag Res 2020 19;12:4735-4745. Epub 2020 Jun 19.

Department of Medical Cellular Biology and Genetics, Shanxi Medical University, Taiyuan 030001, People's Republic of China.

Purpose: SET has been proven to be an oncogene, which promotes the initiation and progression in several kinds of malignant carcinomas. However, the expression and its functional roles in colorectal carcinoma (CRC) remained unknown.

Materials And Methods: CRC tissues samples, CRC cell lines and xenograft mouse tumors were used in this study. Read More

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http://dx.doi.org/10.2147/CMAR.S255930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310974PMC

Silencing of lncRNA LINC00346 Inhibits the Proliferation and Promotes the Apoptosis of Colorectal Cancer Cells Through Inhibiting JAK1/STAT3 Signaling.

Authors:
Dan Li Shuang Wen

Cancer Manag Res 2020 16;12:4605-4614. Epub 2020 Jun 16.

Department of Pathology, The Friendship Hospital of Dalian, Dalian City, Liaoning Province 116000, People's Republic of China.

Purpose: The study was aimed to investigate the effect and mechanism of lncRNA LINC00346 on cell proliferation and apoptosis of colorectal cancer (CRC).

Methods: The expression of lncRNA LINC00346 in CRC tissues and cells was detected by qRT-PCR. LINC00346 was overexpressed and silenced in HT29 and LoVo cells by the transfection of pcDNA-LINC00346 and si-LINC00346. Read More

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http://dx.doi.org/10.2147/CMAR.S249491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305831PMC

Laparoscopic Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m.

In Vivo 2020 Jul-Aug;34(4):2079-2085

Department of Surgery, Yokohama City University, Yokohama, Japan.

Aim: To compare long- and short-term outcomes of laparoscopic surgery with those of open surgery for patients with colorectal cancer and body mass index over 25 kg/m Patients and Methods: This multicentre, retrospective study analysed clinical records and identified 178 patients with body mass index over 25 kg/m who underwent surgery for colon and rectosigmoid cancer between 2000 and 2016. After applying propensity score matching, 96 patients were finally included. The primary outcome was the 3-year recurrence-free survival rate, and the secondary outcomes were short-term results during and after surgery. Read More

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http://dx.doi.org/10.21873/invivo.12011DOI Listing

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases - The Hong Kong experience and literature review.

Asian J Surg 2020 Jun 27. Epub 2020 Jun 27.

Division of Colorectal Surgery, Department of Surgery, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used to treat peritoneal metastases from appendiceal or colorectal origin. We evaluate our institution's experience and survival outcomes with this procedure, and its efficacy in symptom relief.

Methods: This is a single-centre retrospective observational study on patients with peritoneal metastases (PM) from appendiceal neoplasm or colorectal cancer who underwent CRS/HIPEC in Queen Mary Hospital. Read More

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http://dx.doi.org/10.1016/j.asjsur.2020.05.010DOI Listing

An Electronic Questionnaire to Survey Colorectal Cancer Screening Status and Identify High-Risk Cohorts in Large Health Care Organizations.

Am J Med Qual 2020 Jul 1:1062860620937236. Epub 2020 Jul 1.

Penn State Milton S. Hershey Medical Center, Hershey, PA.

Though improved screening practices have reduced the incidence and mortality of colorectal cancer (CRC), screening rates continue to be suboptimal. This is especially true of high-risk individuals, who are difficult for clinicians to identify during a typical health care encounter. The authors developed an electronic patient questionnaire that determined an individual's CRC screening status and identified high-risk individuals. Read More

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http://dx.doi.org/10.1177/1062860620937236DOI Listing

Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer.

Korean J Intern Med 2020 Jul 2. Epub 2020 Jul 2.

Division of Medical Oncology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background/aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. Read More

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http://dx.doi.org/10.3904/kjim.2019.249DOI Listing

Towards Standardization of Liver Resections in India: Five Hundred Consecutive Oncological Liver Resections- Trends, Techniques and Outcomes.

J Gastrointest Cancer 2020 Jun 29. Epub 2020 Jun 29.

Department of Surgical Oncology-GI & HPB Services, Homi Bhabha National Institute, Tata Memorial Hospital, Dr Ernest Borges Road, Parel, Mumbai, Maharashtra, India.

Purpose: To study the trends, techniques, outcomes and improvisations of liver resections over the study period.

Methods: We analysed prospectively maintained database of patients undergoing liver resections for oncological indications at Tata Memorial Centre, Mumbai, India from June 2010 to October 2016.

Results: Five hundred sixteen patients were operated with median age of 55 years and male to female ratio of 1. Read More

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http://dx.doi.org/10.1007/s12029-020-00444-6DOI Listing

Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care: a cohort study.

Int J Colorectal Dis 2020 Jun 29. Epub 2020 Jun 29.

School of Medical Sciences, University Health Care Research Centre, Örebro University, Örebro, Sweden.

Background: Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and without histories of rectal bleeding, in the diagnosis of CRC. Read More

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http://dx.doi.org/10.1007/s00384-020-03672-1DOI Listing

Landscape of RAS Variations in 17,993 Pan-cancer Patients Identified by Next-generation Sequencing.

Pathol Oncol Res 2020 Jun 30. Epub 2020 Jun 30.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, China.

RAS family genes (HRAS, KRAS and NRAS) were frequently observed in several tumors. The expression of constitutively active RAS proteins mediated by RAS variations promote the development of tumors. KRAS is an important prognostic and drug resistance biomarker. Read More

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http://dx.doi.org/10.1007/s12253-020-00845-9DOI Listing

A novel protective role for microRNA-3135b in Golgi apparatus fragmentation induced by chemotherapy via GOLPH3/AKT1/mTOR axis in colorectal cancer cells.

Sci Rep 2020 Jun 29;10(1):10555. Epub 2020 Jun 29.

Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, San Lorenzo 290 col del Valle, C.P. 03100, Mexico City, México.

Chemotherapy activates a novel cytoplasmic DNA damage response resulting in Golgi apparatus fragmentation and cancer cell survival. This mechanism is regulated by Golgi phosphoprotein-3 (GOLPH3)/Myo18A/F-actin axis. Analyzing the functions of miR-3135b, a small non-coding RNA with unknown functions, we found that its forced overexpression attenuates the Golgi apparatus fragmentation induced by chemotherapeutic drugs in colorectal cancer (CRC) cells. Read More

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http://dx.doi.org/10.1038/s41598-020-67550-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324564PMC
June 2020
5.078 Impact Factor

Multiclass cancer classification in fresh frozen and formalin-fixed paraffin-embedded tissue by DigiWest multiplex protein analysis.

Lab Invest 2020 Jun 29. Epub 2020 Jun 29.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Histomorphology and immunohistochemistry are the most common ways of cancer classification in routine cancer diagnostics, but often reach their limits in determining the organ origin in metastasis. These cancers of unknown primary, which are mostly adenocarcinomas or squamous cell carcinomas, therefore require more sophisticated methodologies of classification. Here, we report a multiplex protein profiling-based approach for the classification of fresh frozen and formalin-fixed paraffin-embedded (FFPE) cancer tissue samples using the digital western blot technique DigiWest. Read More

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http://dx.doi.org/10.1038/s41374-020-0455-yDOI Listing

Elevated Expression of RIOK1 Is Correlated with Breast Cancer Hormone Receptor Status and Promotes Cancer Progression.

Cancer Res Treat 2020 May 8. Epub 2020 May 8.

Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Purpose: RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers-such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Read More

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http://dx.doi.org/10.4143/crt.2020.187DOI Listing

Small bowel adenocarcinoma in Crohn's disease: a rare but devastating complication.

Tech Coloproctol 2020 Jun 28. Epub 2020 Jun 28.

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Main Campus, 9500 Euclid Ave, A31, Cleveland, OH, 44122, USA.

Background: Small bowel adenocarcinoma (SBA) remains a rare entity but occurs at increased frequency in the setting of chronic Crohn's disease (CD). Our aim was to study the presentation, diagnosis and prognosis of SBA in patients undergoing surgery for CD at a single institution.

Methods: We reviewed the medical records of all patients with CD complicated by adenocarcinoma of the small bowel from 2000 to 2017. Read More

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http://dx.doi.org/10.1007/s10151-020-02269-8DOI Listing

A Retrospective Review of Tumor Lysis Syndrome Associated With Colorectal Cancer.

Cureus 2020 May 24;12(5):e8257. Epub 2020 May 24.

Genitourinary Oncology, Creighton University School of Medicine/University of Arizona Cancer Center at Dignity Health, Phoenix, USA.

Tumor lysis syndrome (TLS) is a life-threatening oncologic condition that is most commonly linked with hematologic malignancies and uncommonly seen in solid tumors, including colorectal cancer (CRC). Therefore, a lack of awareness regarding TLS in CRC could lead to significant morbidity and mortality. This study aims to explore the clinical characteristics and outcomes of TLS in patients with CRC. Read More

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http://dx.doi.org/10.7759/cureus.8257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313428PMC

Malignant triton tumor below the peritoneal reflection: a case report.

J Surg Case Rep 2020 Jun 19;2020(6):rjaa171. Epub 2020 Jun 19.

Englewood Health Medical Center, Englewood, NJ, USA.

Malignant triton tumor (MTT) is a rare subtype of malignant peripheral nerve sheath tumors (MPNSTs) histologically defined by rhabdomyoblastic differentiation. MTTs are primarily found in the head, neck, extremities and trunk, but rare cases of MTT within the buttock, the mediastinum and the retroperitoneum have also been documented. We present the case of a 47-year-old male patient who initially presented with right flank pain and hematuria in July 2019, who was found to have a large pelvic mass below peritoneal reflection. Read More

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http://dx.doi.org/10.1093/jscr/rjaa171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303023PMC

[Effects of probiotics on the intestinal microecological abnormalities and colorectal cancer of mice induced by high-fat diet].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jul;23(Z1):77-85

Department of General Surgery, the Tenth People's Hospital, Tongji University, Shanghai 200072, China; Research Institute of Intestinal Diseases, Tongji University School of Medicine, Shanghai 200072, China; Department of Difficult Diagnosis and Treatment Center of Abdominal Surgery, The Tenth People's Hospital, Tongji University, Shanghai 200072, China.

To establish the mice colorectal cancer (CRC) model induced by AOM/DSS with the intervention of high fat diet and probiotics, and to explore the potential mechanism of probiotics intervention in regulating intestinal flora disturbance and antitumor efficiency. Forty 8-week-old male C57BL/6J mice were randomly divided into 4 groups with 10 mice in each group: HFD group, HDF with probiotics intervention (HFD+P) group, normal diet (ND) group, normal diet with probiotics intervention (ND+P) group. The probiotic groups were administered with probiotics preparation by gavage. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200417-00223DOI Listing

[Changes in the classification of malignant colon epithelial neoplasms. (WHO, 2019, 5th edition)].

Arkh Patol 2020 ;82(3):38-46

M.V. Lomonosov Moscow State University, Medical Research and Educational Center, Moscow, Russia.

There are not many changes compared to 2010 in WHO classification (2019) of colon adenocarcinomas. Cribriform comedo-type adenocarcinoma (ICD-O code: 8201/3), spindle cell carcinoma (8032/3), squamous cell carcinoma (8070/3) are excluded; carcinoma with a sarcomatoid component (8033/3), poorly cohesive carcinoma (8490/3) and adenoma-like adenocarcinoma (8262/3) were added. The important histological characteristics in the conclusion should indicate the presence of lymphatic invasion, intra- and extramural vascular invasion, perineural invasion, grading, «tumor budding» and the immune microenvironment. Read More

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http://dx.doi.org/10.17116/patol20208203138DOI Listing
January 2020

Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1499-1509. Epub 2020 Jun 1.

HIV/STI Surveillance Research Center, and WHO Collaborating center for HIV surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Polyomaviruses including BK virus (BKV) and JC virus (JCV) are widespread in human and have been associated with colorectal cancer (CRC) in some studies. The aim of present systematic review and meta-analysis article is to calculate the pooled prevalence of BKV and JCV in patients with CRC and assessing their association with this malignancy.

Materials And Methods: Domestic databases and Sciences Direct, PubMed, ProQuest, Web of Sciences and Scopus were searched for relevant articles up to 2nd  June 2019Two independent reviewers extracted the related data from eligible articles. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1499DOI Listing

Dysregulation of microRNA expression during the progression of colorectal tumors.

Pathol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Iwate, Japan.

MicroRNAs (miRNAs) are potential biomarkers of neoplastic lesions, but additional information on dysregulated miRNA expression during progression of the adenoma-adenocarcinoma sequence may be helpful to identify the role of miRNAs in this sequence. We examined the expression levels of 13 miRNAs (hsa-miRNA-19a-3p, hsa-miRNA-21-5p, hsa-miRNA-27a-3p, hsa-miRNA-27b-3p, hsa-miRNA-31-5p, hsa-miRNA-34b-3p, hsa-miRNA-125b-5p, hsa-miRNA-143-3p, miRNA-191-5p, hsa-miRNA-193b-3p, hsa-miRNA-195-5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. These 120 tumors were divided into two cohorts, that is, cohort 1 (60 cases) and cohort 2 (for validation; 60 cases). Read More

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http://dx.doi.org/10.1111/pin.12975DOI Listing

Neoplastic meningitis due to colorectal cancer.

Clin J Gastroenterol 2020 Jun 26. Epub 2020 Jun 26.

Department of Health Nutrition, Hiroshima Shudo University, 1-1-1, Ozuka-higashi, Asaminami-Ku, Hiroshima, 731-3195, Japan.

Herein, we describe a rare case of neoplastic meningitis in a 54-year-old male with a history of colorectal cancer. He first noticed a loss of sensation in his left thigh along with back pain. Magnetic resonance imaging showed a tumor lesion in the cauda equina. Read More

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http://dx.doi.org/10.1007/s12328-020-01166-9DOI Listing

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression.

Nat Commun 2020 Jun 26;11(1):3259. Epub 2020 Jun 26.

The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, hematogenous F. nucleatum can colonize CRC tissue using its lectin Fap2, which attaches to tumor-displayed Gal-GalNAc. Read More

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http://dx.doi.org/10.1038/s41467-020-16967-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320135PMC

SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells.

J Immunother Cancer 2020 Jun;8(1)

Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain

Background: Tumor-infiltrating lymphocytes (TILs), mainly CD8 cytotoxic T lymphocytes (CTL), are linked to immune-mediated control of human cancers and response to immunotherapy. Tumors have nonetheless developed specific mechanisms that selectively restrict T cell entry into the tumor microenvironment. The extracellular superoxide dismutase (SOD3) is an anti-oxidant enzyme usually downregulated in tumors. Read More

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http://dx.doi.org/10.1136/jitc-2019-000432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319787PMC

Recent insights into the role of L1CAM in cancer initiation and progression.

Int J Cancer 2020 Jun 25. Epub 2020 Jun 25.

Institute for Experimental Cancer Research, Kiel University and University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.

First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al. Read More

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http://dx.doi.org/10.1002/ijc.33177DOI Listing

Diagnostic Value of Plasma Long Non-coding RNA HOTTIP as a Non-invasive Biomarker for Colorectal Cancer (A Case- Control Study).

Int J Mol Cell Med 2019 ;8(4):240-247

Research center for Molecular Medicine, Department of Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran.

Long non-coding RNAs (lncRNAs), associated with various cancers including colorectal cancer (CRC), could be collected from body fluids easily. Our aims were to determine the expression level of lncRNA in plasma samples of healthy individuals and CRC patients as well as their relationship with clinico-pathological characteristics of patients. First, total RNA was extracted from the plasma samples of 100 subjects including 50 patients and 50 age and sex matched healthy persons. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.4.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305463PMC
January 2019

Stereotactic Image-Guided Microwave Ablation for Malignant Liver Tumors-A Multivariable Accuracy and Efficacy Analysis.

Front Oncol 2020 10;10:842. Epub 2020 Jun 10.

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Therapeutic success of thermal ablation for liver tumors depends on precise placement of ablation probes and complete tumor destruction with a safety margin. We investigated factors influencing targeting accuracy and treatment efficacy of percutaneous stereotactic image-guided microwave ablation (SMWA) for malignant liver neoplasms. : All consecutive patients treated with SMWA for malignant liver tumors over a 3-year period were analyzed. Read More

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http://dx.doi.org/10.3389/fonc.2020.00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298123PMC

Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling PHLPP1 in colorectal cancer.

Cancer Biol Med 2020 May;17(2):343-356

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver V6T 1Z4, Canada.

Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that facilitates collagen maturation. Its role in cancer remains largely unknown. In this study, we investigated the roles of HSP47 in colorectal cancer (CRC) and therapy resistance. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309463PMC

Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas.

Sci Rep 2020 Jun 25;10(1):10373. Epub 2020 Jun 25.

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Skåne University Hospital, 22185, Lund, Sweden.

The outcome of periampullary adenocarcinomas remains poor with few treatment options. Podocalyxin-like protein (PODXL) is an anti-adhesive protein, the high expression of which has been shown to confer a poor prognosis in numerous malignancies. A correlation and adverse prognostic synergy between PODXL and the epidermal growth factor receptor (EGFR) has been observed in colorectal cancer. Read More

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http://dx.doi.org/10.1038/s41598-020-67187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316735PMC

Involvement of SASH1 in the Maintenance of Stable Cell-Cell Adhesion.

Biochemistry (Mosc) 2020 Jun;85(6):660-667

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, 115478, Russia.

SASH1 is an adapter and signaling protein that contains SH3 and SAM domains responsible for protein-protein interactions. SASH1 downregulation has been observed in many tumors. We examined localization of SASH1 in cultures of normal IAR-20 epithelial cells and HT-29 colorectal cancer cells using immunofluorescence staining and confocal microscopy. Read More

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Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger.

Clin Gastroenterol Hepatol 2020 Jun 22. Epub 2020 Jun 22.

Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands; Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.

Background & Aims: Colorectal cancers (CRCs) are rare in adolescents and adults 25 years or younger. We analyzed clinical, pathology, and molecular features of colorectal tumors from adolescents and young adults in an effort to improve genetic counselling, surveillance, and ultimately treatment and outcomes.

Methods: We analyzed clinical data and molecular and genetic features of colorectal tumor tissues from 139 adolescents or young adults (25 years or younger; median age, 23 years; 58% male), collected from 2000 through 2017; tumor tissues and clinical data were obtained from the nationwide network and registry of histo- and cytopathology and the Netherlands Cancer Registry, respectively. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.034DOI Listing

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.

Gastroenterology 2020 Jun 18. Epub 2020 Jun 18.

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany. Electronic address:

Background & Aims: Unregulated activity of interleukin 22 (IL22) promotes intestinal tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called IL22BP). We studied if alterations in IL22BP contribute to colorectal carcinogenesis in humans and mice. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.06.033DOI Listing

Activities of matrix metalloproteinase-2, matrix metalloproteinase-9, and serine proteases in samples of the colorectal mucosa of Miniature Dachshunds with inflammatory colorectal polyps.

Am J Vet Res 2020 Jul;81(7):572-580

Objective: To investigate the activities of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) and serine proteases in the colorectal mucosa of Miniature Dachshunds (MDs) with inflammatory colorectal polyps (ICRPs).

Animals: 15 MDs with ICRPs and 5 dogs with non-ICRP-related large bowel diarrhea (controls).

Procedures: Zymographic methods were used to evaluate the activities of MMP-2, MMP-9, latent forms of MMP-2 and MMP-9 (pro-MMP-2 and pro-MMP-9), and serine proteases in inflamed and noninflamed tissue samples from MDs with ICRPs and in noninflamed tissue samples from control dogs. Read More

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http://dx.doi.org/10.2460/ajvr.81.7.572DOI Listing

Mailed fecal immunochemical test outreach for colorectal cancer screening: Summary of a Centers for Disease Control and Prevention-sponsored summit.

CA Cancer J Clin 2020 Jun 25. Epub 2020 Jun 25.

Department of Internal Medicine and LiveStrong Cancer Institutes, Dell Medical School, University of Texas Austin, Austin, Texas.

Uptake of colorectal cancer screening remains suboptimal. Mailed fecal immunochemical testing (FIT) offers promise for increasing screening rates, but optimal strategies for implementation have not been well synthesized. In June 2019, the Centers for Disease Control and Prevention convened a meeting of subject matter experts and stakeholders to answer key questions regarding mailed FIT implementation in the United States. Read More

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http://dx.doi.org/10.3322/caac.21615DOI Listing

Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values.

Pathol Oncol Res 2020 Jun 24. Epub 2020 Jun 24.

Department of Biopathology, Academic Hospital, rue du Général Koenig, 51100, Reims, France.

Describe clinical, histological and molecular charatcteristics and prognosis values of the serrated candidate markers AnnexinA10 and Gremlin1 in colon adenocarcinomas. Immunohistochemical expression of AnnexinA10 and Gremlin1 was evaluated on 346 colonic adenocarcinomas. Clinicopathological, molecular features and prognostic characteristics were then evaluated. Read More

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http://dx.doi.org/10.1007/s12253-020-00857-5DOI Listing

Metastatic Colorectal Cancers with Mismatch Repair Deficiency Result in Worse Survival Regardless of Peritoneal Metastases.

Ann Surg Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, University of Chicago, Chicago, IL, USA.

Background: Mismatch-repair deficiency (dMMR) predicts worse chemoresponsiveness but better survival in early-stage colorectal adenocarcinoma. This study examined metastatic colorectal and appendix cancers with and without peritoneal metastasis (PM) in the National Cancer Database (NCDB), hypothesizing that dMMR tumors show better survival.

Methods: Stage 4 colon, rectum, and appendix cancers (2010-2016) were identified in the NCDB (including goblet cell carcinoids, excluding neuroendocrine tumors). Read More

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http://dx.doi.org/10.1245/s10434-020-08733-xDOI Listing

Machine learning-based analysis of CT radiomics model for prediction of colorectal metachronous liver metastases.

Abdom Radiol (NY) 2020 Jun 24. Epub 2020 Jun 24.

Department of Radiology, Netherland Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands.

Purpose: Early identification of patients at risk of developing colorectal liver metastases can help personalizing treatment and improve oncological outcome. The aim of this study was to investigate in patients with colorectal cancer (CRC) whether a machine learning-based radiomics model can predict the occurrence of metachronous metastases.

Methods: In this multicentre study, the primary staging portal venous phase CT of 91 CRC patients were retrospectively analysed. Read More

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http://dx.doi.org/10.1007/s00261-020-02624-1DOI Listing

[Transanal total mesorectal excision-Indications, technique and results].

Chirurg 2020 Jun 24. Epub 2020 Jun 24.

Chirurgische Klinik, Charité Universitätsmedizin Berlin, Berlin, Deutschland.

Total mesorectal excision (TME) has become the standard treatment for rectal cancer in the middle and lower third. Meanwhile, many international trials have confirmed the noninferiority of laparoscopic TME compared to the open technique. Nevertheless, in the presence of anatomical limitations, such as narrow, obese, male pelvises as well as large rectal tumors, the adequate resection of the lower third of the rectum according to oncological criteria, is still challenging even for specialized colorectal surgeons. Read More

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http://dx.doi.org/10.1007/s00104-020-01223-6DOI Listing

Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Front Oncol 2020 9;10:917. Epub 2020 Jun 9.

Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Colorectal adenocarcinoma with mucinous component (AWMC) is a special entity of colorectal cancer. The study is aimed at analyzing the clinicopathological characteristics, mutation spectrum, and prognosis of AWMC and comparing it with classical adenocarcinoma (AC) in a Chinese cohort. One hundred eight AMWC and 204 AC patients were included. Read More

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http://dx.doi.org/10.3389/fonc.2020.00917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296099PMC

Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota.

Front Oncol 2020 3;10:710. Epub 2020 Jun 3.

Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Sucralose is a calorie-free high-intensity artificial sweetener that is widely used in thousands of foods and beverages all over the world. Although it was initially regarded as a safe, inert food additive, its adverse effect on gut microbiota and health has drawn more and more attention as evidence accumulates. Studies by us and others revealed that sucralose exacerbated gut damage and inflammation in animal models for inflammatory bowel disease (IBD), including those for both ulcerative colitis, and Crohn's disease. Read More

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http://dx.doi.org/10.3389/fonc.2020.00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286428PMC

Combined robotic and cystoscopic surgery for rectal cancer invading urinary bladder.

Int Cancer Conf J 2020 Jul 1;9(3):102-106. Epub 2020 Apr 1.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.

Although the application of laparoscopic rectal surgery has been widely accepted by accumulated evidence, it remains technically difficult in some cases of obesity, narrow male pelvis, bulky tumors, or involvement of adjacent organs. After robotic rectal surgery has been covered by the health insurance system in Japan since April 2018, we have employed robotic rectal surgery for an increasing number of cases by taking advantages of its 3D vision and wrist function. When a colorectal cancer involves the urinary bladder, the surgical treatment of choice is an anterior resection with en bloc (partial or total) bladder resection, depending on the site and extent of bladder involvement. Read More

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http://dx.doi.org/10.1007/s13691-020-00413-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297884PMC

Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model.

Int J Nanomedicine 2020 29;15:3843-3850. Epub 2020 May 29.

Nanobiotix, Paris, France.

Purpose: Despite tremendous results achieved by immune checkpoint inhibitors, most patients are not responders, mainly because of the lack of a pre-existing anti-tumor immune response. Thus, solutions to efficiently prime this immune response are currently under intensive investigations. Radiotherapy elicits cancer cell death, generating an antitumor-specific T cell response, turning tumors in personalized in situ vaccines, with potentially systemic effects (abscopal effect). Read More

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http://dx.doi.org/10.2147/IJN.S250490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280060PMC