Search Our Scientific Publications & Authors

Am J Clin Nutr 2018 Dec;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Read More

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan.

Background: Application of next-generation DNA sequencing (NGS) has recently become increasingly common in the field of clinical oncology in several countries around the world. In Japan also, a system for applying NGS to routine clinical practice is gradually being established. During this process, we introduced in Japan the tumor-profiling MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) assay. Read More

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

Dig Dis 2018 Dec 12:1-6. Epub 2018 Dec 12.

Background: Colonoscopy is the gold standard for adenoma detection. All endoscopists who perform colonoscopy must by mandate be skilled to perform polypectomy. However, there are significant differences between endoscopists in terms of the polyp detection rate and in the effectiveness of polypectomy. Read More

Oncology 2018 Dec 12:1-8. Epub 2018 Dec 12.

Department of Oncology, National Taiwan University Hospital, Taipei City,

Objective: We aimed to study the prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC).

Material And Methods: We analyzed CIMP in stage I-IV CRC specimens from patients who were diagnosed between 2005 and 2013. CIMP status was determined using a 5-gene MethyLight-based assay. Read More

Cell Rep 2018 Dec;25(11):3036-3046.e6

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA; Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address:

IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here that inflammation induces the accumulation of CD11bGr1 myeloid-derived suppressor cells (MDSCs) that express high levels of IL-10 in colon tissue. Read More

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: The occurrence of anastomotic leakage is still a life-threatening complication for patients after colorectal surgery. In literature not only an impact on the short-term outcome but also on long-term survival and local recurrence of colorectal cancer patients is discussed.

Objective: This study aimed to investigate the impact of anastomotic leakage on long-term survival and local recurrence. Read More

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: Transversus abdominis plane block may improve analgesia after colorectal surgery; however, techniques remain unstandardized and results are conflicting.

Objective: The purpose of this study was to compare laparoscopic and ultrasound-guided transversus abdominis plane block with no block in minimally invasive colorectal surgery.

Design: This was a randomized controlled trial. Read More

Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Department of Anorectal Surgery, First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (TCM), Qinhuai District, Nanjing, Jiangsu Province.

This meta-analysis aimed to compare the clinical outcomes of stapled hemorrhoidectomy (SH) and transanal hemorrhoidal dearterialization (THD) for treating hemorrhoidal disease. Randomized control trials (RCTs) comparing SH with THD were searched in databases, including MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Library database. Nine RCTs, with 1077 patients, were included in this meta-analysis. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):306-313

Shahid Sadoughi University of Medical Sciences, Department of Medical Genetics, Yazd, Iran.

Background: Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive.

Objective: We conducted this meta-analysis to evaluate the association of promoter region polymorphisms of IL-10 with CRC.

Methods: Eligible articles were identified by a search of several bibliographic databases for the period up to March 15, 2018. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):258-263

Universidade Federal de Goiás, Faculdade de Medicina, Hospital das Clínicas, Departamento de Cirurgia, Goiânia, GO, Brasil.

Background: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial.

Objective: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):237-241

Shiraz University of Medical Sciences, Department of Bacteriology and Virology, Shiraz, Iran.

Background: Cancers are one of the most important causes of death in the world. According to their high incidence and mortality, gastrointestinal cancers have particular importance among other cancers.

Objective: Therefore, this study was conducted to investigate the mortality change trends of gastrointestinal cancers in Iran. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1406. Epub 2018 Dec 6.

Medical School, University of Southern Santa Catarina, Palhoça.

Background: Deep infiltrating colorectal endometriosis may severely affect the quality of life and fertility of patients. Although segmental resection is a therapeutic option that provides positive outcomes in the management of symptoms, its functional effects are still unproven.

Aim: Assess the late impact of the laparoscopic approach in treating deep infiltrating endometriosis with segmental colorectal resection. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1404. Epub 2018 Dec 6.

Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Colorectal Surgery, Su zhou, Jiang su, China.

Background: It is important but difficult to treat complex fistula-in-ano due to the high recurrent rate and following incontinence. Ligation of the intersphincteric fistula tract (LIFT), a novel surgical procedure with the advantage of avoiding anal incontinence, has a variable success rate of 57-94.4 %. Read More

Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.

Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Read More

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Division of Surgical Oncology, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: This report describes patterns of disease recurrence after optimal cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) of colorectal (CRC) and appendiceal adenocarcinoma (AC) origin.

Methods: Patients undergoing optimal CRS/HIPEC (2007-2016) at the authors' institution were retrospectively reviewed from a prospectively maintained database. Data regarding disease recurrence were analyzed. Read More

Int J Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.

Purpose: Postoperative infection has seriously affected the prognosis of cancer patients, while probiotics have been increasingly used to prevent postoperative infection in clinical practice. This study aimed to evaluate the preventive effect of probiotics on infection after colorectal cancer (CRC) surgery.

Methods: Related clinical trial reports were collected from Pubmed, Embase, Cochrane Library as well as China National Knowledge Infrastructure (CNKI) databases. Read More

Biomed Res Int 2018 14;2018:4039173. Epub 2018 Nov 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Read More

Biomed Res Int 2018 14;2018:1460835. Epub 2018 Nov 14.

Second Department of Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, 12 Jiankang Road, Shijiazhuang, Hebei 050011, China.

Lynch syndrome is a genetically and clinically heterogeneous disorder; it is caused by a germline mutation in DNA mismatch repair (MMR) genes. Individuals with a heterozygous mutation in MLH1 have an increased risk for developing colorectal cancer. Here we described a 5-generation Chinese Lynch syndrome family with different severity and onset age. Read More

Front Med (Lausanne) 2018 27;5:324. Epub 2018 Nov 27.

Division of Gastroenterology & Hepatology, Department of Medicine, Penn State College of Medicine, Hershey, PA, United States.

Hypoalgesic inflammatory bowel disease (IBD), a condition in which patients with active disease do not perceive and/or report abdominal pain, is associated with serious complications and there is a lack of cost-effective, reliable diagnostic methods to identify "at-risk" patients. The voltage-gated sodium channels (VGSC's), Na1.7, Na1. Read More

Case Rep Surg 2018 14;2018:6826079. Epub 2018 Nov 14.

Department of Surgery, Nagoya Tokushukai General Hospital, 2-52 Kouzouji-cho kita, Kasugai-City, Aichi 487-0016, Japan.

A 78-year-old woman with lumboperitoneal (LP) shunt was diagnosed with advanced cancer of the ascending colon. Laparoscopic right hemicolectomy was performed without manipulating the catheter. The patient's postoperative course was uneventful, with no shunt-related complications or neurological deficit. Read More

Front Genet 2018 27;9:570. Epub 2018 Nov 27.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

Accumulating evidence from small-scale studies has suggested that allele-specific expression (ASE) plays an important role in tumor initiation and progression. However, little is known about genome-wide ASE in tumors. In this study, we conducted a comprehensive analysis of ASE in individuals with colorectal cancer (CRC) on a genome-wide scale. Read More

Clin Epidemiol 2018 23;10:1733-1742. Epub 2018 Nov 23.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark,

Background: Predictors of participation in colorectal cancer screening with a stool sample screening modality have been widely studied, but adherence to subsequent diagnostic colonoscopy after a positive screening test has received less attention. We aimed to determine predictors of adherence to diagnostic colonoscopy in the Danish Colorectal Cancer Screening Program.

Methods: We conducted a cross-sectional study using data from National Health Service registries. Read More

Cancer Manag Res 2018 23;10:6257-6261. Epub 2018 Nov 23.

Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People's Republic of China,

Introduction: Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood.

Methods: In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case-control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2). Read More

Cancer Manag Res 2018 22;10:6217-6226. Epub 2018 Nov 22.

Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, People's Republic of China,

Purpose: The relationship between the pharmacokinetics of irinotecan and outcomes of advanced colorectal cancer is unclear, and few studies have examined individualized irinotecan-based chemotherapy depending on plasma 7-ethyl-10-hydroxy camptothecin (SN-38) levels and dihydropyrimidine dehydrogenase (DPD) activity, particularly for the UGT1A16 or UGT1A128 heterozygous type.

Methods: This study retrospectively explored the relationship among plasma SN-38 level 1.5 hours after critical enzyme for irinotecan (CPT-11) administration (C), plasma SN-38 level 49 hours after CPT-11 administration (C), DPD activity, and clinical outcomes for the UGT1A16 and UGT1A128 heterozygous types. Read More

Cancer Manag Res 2018 22;10:6157-6166. Epub 2018 Nov 22.

Department of Pathology, The Affiliated Hexian Memorial Hospital of Southern Medical University, Guangzhou, China,

Background: Establishment of cohesion 1 homolog 2 (ESCO2) plays important roles in the regulation of cohesion and genomic stability and has been implicated in human cancers. Yet, its clinical significance and biological function in colorectal cancer (CRC) are unknown.

Methods: The expression of ESCO2 was examined by quantitative real-time PCR, Western blot, and immunohistochemistry. Read More

Cancer Manag Res 2018 22;10:6129-6141. Epub 2018 Nov 22.

Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, China,

Background: Dysregulation of erythropoietin-producing hepatoma (Eph) proteins in human cancers is extensively documented but not clear in colorectal cancer (CRC). In this study, we aimed to investigate the role of Notch signaling pathway and epigenetic modification of EPHB2 and EPHB4 expression in serrated neoplasia development.

Methods: The expression of EPHB2 and EPHB4 in CRC clinical specimens and cell lines were determined by immunohistochemistry, Western blot, and real-time PCR. Read More

Cancer Manag Res 2018 21;10:6061-6070. Epub 2018 Nov 21.

Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Guishan, Taoyuan, Taiwan, Republic of China,

Purpose: Fewer treatment options are available for refractory metastatic colorectal cancer (mCRC). In early trials, S-1 monotherapy was effective for mCRC patients after chemotherapy failure and its combination with oral leucovorin therapy offers promising results in untreated mCRC. Hence, we conduct a Phase II trial to assess the efficacy of S-1 plus oral leucovorin (SL) in refractory mCRC that progressed after multiple prior standard therapies. Read More

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

Indian J Surg Oncol 2018 Dec 23;9(4):547-551. Epub 2018 Jul 23.

5Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.

Involvement of the bladder by colorectal cancer is sufficiently rare to be encountered by an individual surgeon on an infrequent basis. Extirpative procedures for advanced colorectal cancers can involve partial/total bladder resections. In patients without evidence of distant metastatic disease, a reasonable therapeutic effect can be expected when negative surgical margins are obtained. Read More

Indian J Surg Oncol 2018 Dec 20;9(4):511-518. Epub 2018 Jul 20.

1Department of Gynaecologic Oncology, CMC Hospital, Vellore, 632004 India.

To evaluate the mortality and morbidity related to bowel resection in women with advanced ovarian carcinoma. Retrospective case series of 47 women with stage III and IV carcinoma ovary who underwent bowel resection, over the period of 5 years from Jan 2011 to Dec 2015. The risk factors for perioperative morbidity and death were determined by regression analysis. Read More

Indian J Surg Oncol 2018 Dec 18;9(4):495-500. Epub 2018 Aug 18.

Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra 400012 India.

To compare the impact of adjuvant chemo-radiotherapy (ACRT) versus adjuvant chemotherapy (ACT) alone on recurrence and survival in patients with stage II and III rectal adenocarcinoma undergoing upfront curative resection. Prospective observational review of colorectal database at Tata Memorial Hospital from July 2010 to March 2015 identified 84 patients who underwent upfront curative resection for stage II or III rectal cancer. None of the patient received preoperative chemo-radiation. Read More

Indian J Surg Oncol 2018 Dec 2;9(4):488-494. Epub 2018 Aug 2.

1Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel, Mumbai, Maharashtra 400012 India.

The multimodal treatment for advanced rectal adenocarcinoma mandates accurate preoperative staging with contrast-enhanced computed tomography (CECT) of the thorax, abdomen, and pelvis, and magnetic resonance imaging (MRI) of the pelvis. Unlike gastric cancer, the role of staging laparoscopy (SL) in advanced colorectal cancer has not been evaluated. This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Read More

Indian J Surg Oncol 2018 Dec 18;9(4):461-471. Epub 2018 May 18.

2Department of Internal Medicine, Division of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

The most common site of blood-borne metastases from colorectal cancers (CRC) is the liver. Resection of (liver) metastases is a part of standard treatment of metastatic colorectal cancer. Hepatic resection is the first-line treatment of liver metastases, with 5-year survival rates between 25 and 58%. Read More

Indian J Surg Oncol 2018 Dec 18;9(4):456-460. Epub 2018 May 18.

2Department of Surgery, Westchester Medical Center, 100, Woods Road, Valhalla, NY 10523 USA.

The liver is the most common site for metastasis from colorectal cancers (CRCs). There are so many new armamentarium, which have increased the life expectancy and progression-free survival. There are various available guidelines, such as NCCN, ESMO, and ASCO, which provide an insight into the latest modalities and new protocols. Read More

Indian J Surg Oncol 2018 Dec 4;9(4):452-455. Epub 2018 Sep 4.

3Department of Surgical Oncology, Tata Memorial Center, Mumbai, India.

Close surveillance of colorectal cancer (CRC) patients is helpful as early detection of resectable metastasis has a survival benefit. Ultrasonography (USG) is a frequently used modality to detect liver recurrence, although international guidelines do not include it. To evaluate the potential added role of USG in early detection of CRC recurrence. Read More

Indian J Surg Oncol 2018 Dec 23;9(4):440-441. Epub 2017 Oct 23.

Division of Surgical Oncology, Department of Surgery, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 USA.

Oncogene 2018 Dec 11. Epub 2018 Dec 11.

Trinity Biomedical Sciences Institute, School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland.

Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the production of the pro-inflammatory cytokines IL-1β and IL-18, and has a key role in pyroptotic cell death. We have previously demonstrated a protective role for caspase-11 during dextran sulphate sodium (DSS)-induced colitis, however the importance of caspase-11 during colorectal tumour development remains unclear. Read More

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.

Objectives: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI).

Methods: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. Read More

Gut 2018 Dec 11. Epub 2018 Dec 11.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.

Objective: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services.

Design: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). Read More

BMC Genomics 2018 Dec 11;19(Suppl 8):857. Epub 2018 Dec 11.

Bioinformatics and Functional Genomics Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Cientificas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.

Background: Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information. Read More

Curr Health Sci J 2015 Jul-Sep;41(3):204-208. Epub 2015 Jan 29.

Department of Cellular and Molecular Biology, University of Medicine and Pharmacy of Craiova.

Purpose: This study aims to determinate the microvessel density at the base of the tumor, as well in tumor's mass, in order to determinate the number of neovascularization vessels (marked with CD105) in comparison with presence or absence of autophagy puncta.

Material/methods: Standard immunohistochemistry was performed on 38 samples of colorectal adenocarcinoma, in order to determinate the presence of autophagy and neovascularization blood vessels with the help of LC3, CD34, CD31 and CD105 antibodies.

Results: The autophagy process was observed in the cancerous cells and was noted as present in both regions of interest from the tumor. Read More

J Mens Health 2013 Mar 12;10(1):14-21. Epub 2013 Nov 12.

Minority Men's Health Center, Glickman Urological and Kidney Institute, The Cleveland Clinic Foundation, Cleveland, Ohio.

Background: African-American men are disproportionately burdened with colorectal cancer (CRC). Research is scarce on the social determinants that may influence CRC screening as the primary strategy for early detection among African-American males.

Methods: African-American men over the age of 18 years ( = 558) were recruited from a community health fair and anonymously surveyed about their health and cancer screening behaviors. Read More

Eur Surg Res 2018 Dec 11;59(5-6):361-370. Epub 2018 Dec 11.

Division of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan,

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Read More

Int J Surg 2018 Dec 8. Epub 2018 Dec 8.

Service de chirurgie hépatobiliaire et pancréatique et de transplantation, Département de chirurgie, Centre Hospitalier de l'Université de Montréal, Site St-Luc, Montréal, QC, Canada.

Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall survival (OS) and lower disease-free survival (DFS). The lack of adjusted models to compare these outcomes is a limitation of these studies since patients requiring PVE may differ significantly from the ones receiving upfront surgery.

Materials And Methods: Prospective cohort study of 128 patients undergoing CLM resection. Read More

Cancer Cell 2018 Dec;34(6):876-878

Clinica Universidad de Navarra, Pamplona, Spain; CIBERONC, Madrid, Spain; Center for applied Medical Research (CIMA), Pamplona, Spain; IDISNA, Pamplona, Spain. Electronic address:

Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving adaptive immune responses. Read More

Cancer Cell 2018 Dec;34(6):1012-1026.e3

INSERM, Laboratory of Integrative Cancer Immunology, Sorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot; Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address:

Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Read More

Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Hospital Senhora da Oliveira, Gastrenterology Department - Guimarães, Portugal.

Aim: Acute lower gastrointestinal bleeding (ALGIB) is a commongastroenterological emergency. Despite this outcomes are difficult to predict Onlyy STRATE and BLEED scores are readily available. The aim of this study was to identify risk factors for severe ALGIB and access the validity of available scores. Read More

Phytother Res 2018 Dec 9. Epub 2018 Dec 9.

The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA.

Protopanaxadiol (PPD), a ginseng metabolite generated by the gut bacteria, was shown to induce colorectal cancer cell death and enhance the anticancer effect of chemotherapeutic agent 5-FU. However, the mechanism by which PPD promotes cancer cell death is not clear. In this manuscript, we showed that PPD activated p53 and endoplasmic reticulum (ER) stress and induced expression of BH3-only proteins Puma and Noxa to promote cell death. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.

The purpose of our study was to investigate the effects of the long noncoding RNA (lncRNA) ABHD11-AS1 on colorectal cancer (CRC) progression and further explore its possible underlying mechanisms. In the study, we found that ABHD11-AS1 was highly expressed in CRC tissues and cell lines. High ABHD11-AS1 expression was correlated with poor overall survival of patients with CRC. Read More