45,134 results match your criteria Colonoscopy

Adjusting detection measures for colonoscopy: how far should we go?

Douglas K Rex

Clin Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

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Clin Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Backgrounds And Aims: Inpatient endoscopy delay (IED) negatively impacts the delivery of high-quality care. We aimed to identify factors associated with IED and evaluate its effect on hospital length-of-stay (LOS) and re-admission.

Methods: Retrospective analysis of all inpatient endoscopies performed between November 2017 to November 2019 at a tertiary care center. Read More

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Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: Phase IIa and IIb multi-center clinical trials.

Eur J Pharm Sci 2021 Jun 8:105904. Epub 2021 Jun 8.

Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences Chengdu, China. Electronic address:

Objective: Ciprofol is a new intravenous anesthetic agent similar to propofol that has the pharmacodynamic characteristics of a rapid rate of onset and recovery in pre-clinical experiments. The aims of the present clinical trials were to compare the efficacy and safety of ciprofol emulsion for sedation or general anesthesia during colonoscopy and to define optimal doses for a subsequent phase III clinical trial.

Methods: A phase IIa multi-center, open-label, non-randomized, positive control, dose-escalating study was performed to determine a recommended phase IIb dose (RP2D) of ciprofol to induce sedation or anesthesia in patients undergoing colonoscopy. Read More

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A Pilot Randomized Trial of Polypectomy Techniques for 4 to 6 mm Colonic Polyps.

J Clin Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Department of Internal Medicine/Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN.

Background And Goals: There is variation in polypectomy techniques for resection of small polyps. Aim was to compare techniques for 4 to 6 mm polyps for recurrent adenoma, efficiency, and adverse events and to establish methodological factors for definitive trial.

Materials And Methods: The study was a randomized controlled trial. Read More

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Endoscopy Training in Small Animal Internal Medicine: A Survey of Residency Training Programs in North America.

J Vet Med Educ 2021 Jun 11:e20200165. Epub 2021 Jun 11.

Competency in multiple endoscopic techniques is a major goal of small animal internal medicine (SAIM) residency programs. Training relies predominantly on mentored supervision of procedures performed on patients. Supplementation of this apprenticeship model with classroom sessions and hands-on laboratories can be advantageous to trainees and patients. Read More

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Safety and efficacy of cold snare polypectomy for small colorectal polyps: A prospective randomized control trial and one-year follow-up study.

Medicine (Baltimore) 2021 Jun;100(23):e26296

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University.

Trial Design: Elimination of small colorectal polyps with cold snare polypectomy (CSP) is reported to be as safe as hot snare polypectomy (HSP). The effectiveness of CSP has not been clearly defined, and the incidence of long-term recurrence has not been determined. We conducted a randomized control study and one-year follow-up study to assess their safety and efficacy. Read More

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Equal Pay for Equal Screening: Impact of Patient and Provider Gender on Reimbursement for Screening Colonoscopy.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

Division of Digestive Diseases, Rush University Medical Center, 1725 W Harrison St Suite 207, Chicago, IL, 60612, USA.

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Gender Differences in Colonoscopy: Implications for Clinical Practice and Female Gastroenterologists.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, USA.

Background And Aims: Performing colonoscopy can be technically challenging in female patients. Female patients may prefer having a female endoscopist. This preference, coupled with the fact that there are fewer female endoscopists, may result in gender differences in colonoscopy practice. Read More

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Single-Day Low-Residue Diet Prior to Colonoscopy Demonstrates Improved Bowel Preparation Quality and Patient Tolerance over Clear Liquid Diet: A Randomized, Single-Blinded, Dual-Center Trial.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Gastroenterology, Long Beach Veterans Affairs Healthcare System, Long Beach, CA, USA.

Background And Aims: Patients often refer to bowel preparation and associated dietary restrictions as the greatest deterrents to having a colonoscopy completed or performed. Large studies comparing a low-residue diet (LRD) and a clear liquid diet (CLD) are still limited. The aim of this study is to compare LRD and CLD with regard to bowel preparation quality, tolerance, and satisfaction among a diverse patient population. Read More

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Splenic Injury After a Colonoscopy: Threading the Scope Carefully in Heritable Connective Tissue Disorders.

Cureus 2021 Jun 4;13(6):e15444. Epub 2021 Jun 4.

Gastroenterology and Hepatology, Ascension Genesys Hospital, Grand Blanc, USA.

Colonoscopies have reduced colorectal cancer (CRC) burden in the United States, and their utility has expanded to include various diagnostic and therapeutic indications. Complications are seen in up to 1% and increase with age and polypectomy. As colonoscopies become widespread, specific populations seem to be at a much higher risk; notably patients with heritable connective tissue disorders (HCTD). Read More

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Primary care providers' responses to unsolicited Lynch syndrome secondary findings of varying clinical significance.

Genet Med 2021 Jun 10. Epub 2021 Jun 10.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Purpose: How primary care providers (PCPs) respond to genomic secondary findings (SFs) of varying clinical significance (pathogenic, uncertain significance [VUS], or benign) is unknown.

Methods: We randomized 148 American Academy of Family Physicians members to review three reports with varying significance for Lynch syndrome. Participants provided open-ended responses about the follow-up they would address and organized the SF reports and five other topics in the order they would prioritize responding to them (1 = highest priority, 6 = lowest priority). Read More

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Will a flexi-sig' do? A retrospective review of colonoscopies indicated by diverticulitis alone.

Surg Endosc 2021 Jun 10. Epub 2021 Jun 10.

Dept. General Surgery, Caboolture Hospital, 97/120 McKean Street, Caboolture, QLD, 4510, Australia.

Background: The incidence of colonic diverticulitis is increasing. In Australia the majority of diverticulitis occurs in the left colon and patients typically undergo colonoscopy following an attack. At present debate exists regarding the utility of this costly procedure and a flexible sigmoidoscopy has been proposed as a cheaper, less invasive alternative. Read More

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Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.

Front Endocrinol (Lausanne) 2021 24;12:695145. Epub 2021 May 24.

Department of Biomedical Sciences and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Treatment with exogenous GLP-2 has been shown to accelerate the growth of intestinal adenomas and adenocarcinomas in experimental models of colonic neoplasia, however, the role of endogenous GLP-2 in tumor promotion is less well known. Mice with a global deletion of the glucagon receptor (Gcgr) display an increase in circulating GLP-1 and GLP-2. Due to the intestinotrophic nature of GLP-2, we hypothesized that Gcgr mice would be more susceptible to colonic dysplasia in a model of inflammation-induced colonic carcinogenesis. Read More

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Benign Colonic Strictures.

Dis Colon Rectum 2021 Jun 8. Epub 2021 Jun 8.

Division of General Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.

Case Summary: A 46-year-old male with no significant past medical or surgical history presented to the emergency department with a 1-week history of worsening constipation, abdominal distension, nausea, and non-bloody, non-bilious emesis. Workup included a computed tomography (CT) scan which was notable for a 5.3 x 3. Read More

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Faecal immunochemical tests safely enhance rational use of resources during the assessment of suspected symptomatic colorectal cancer in primary care: systematic review and meta-analysis.

Gut 2021 Jun 9. Epub 2021 Jun 9.

Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain

Objective: Implementation of faecal immunochemical tests (FIT) as a triage test in primary healthcare may improve the efficiency of referrals without missing cases of colorectal cancer (CRC). We aim to summarise the performance characteristics of FITs for CRC in symptomatic patients presenting to primary healthcare.

Design: We performed a systematic literature review of Medline and EMBASE databases from May 2018 to November 2020. Read More

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Life-threatening haematochezia in a man with two gastrointestinal stromal tumours.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Internal Medicine, United Arab Emirates University, Al Ain, UAE

A man in his 30s was brought by ambulance to the emergency department with a complaint of frank bright red rectal bleeding and dizziness. His blood pressure was 60/18 mm Hg. He was resuscitated with intravenous normal saline and an emergency blood transfusion. Read More

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Endoscopic Retrograde Cholangiopancreatography (ERCP) in Patients With Liver Cirrhosis: Analysis of Trends and Outcomes From the National Inpatient Sample Database.

J Clin Gastroenterol 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, Geisinger Commonwealth School of Medicine, Scranton Hospitalist Department Department of Gastroenterology, Guthrie Robert Packer Hospital, Sayre, PA Departments of Medicine Family Medicine, Samaritan Medical Center, Watertown, NY Department of Medicine, Central Michigan University College of Medicine, Saginaw Department of Gastroenterology, Henry Ford Hospital, Detroit, MI Department of Public Health, Rutgers University, New Brunswick, NJ.

Goals: We aimed to assess outcomes of patients with liver cirrhosis who underwent therapeutic or diagnostic endoscopic retrograde cholangiopancreatography (ERCP) to determine whether these patients had different outcomes relative to patients without cirrhosis.

Background: ERCP is an important procedure for treatment of biliary and pancreatic disease. However, ERCP is relatively technically difficult to perform when compared with procedures such as esophagogastroduodenoscopy or colonoscopy. Read More

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Gender-specific cut-off levels in colorectal cancer screening with fecal immunochemical test: A population-based study of colonoscopy findings and costs.

J Med Screen 2021 Jun 9:9691413211020035. Epub 2021 Jun 9.

Department of Clinical Science and Education, Södersjukhuset (KI SÖS), Karolinska Institutet, Stockholm.

Objective: In the population-based Swedish regional colorectal cancer (CRC) screening program of Stockholm-Gotland using the fecal immunochemical test (FIT), gender-specific cut-off levels of fecal hemoglobin are applied, since previous studies have indicated a lower sensitivity of FIT for CRC in women. The aim was to evaluate the diagnostic yield and the screening costs overall and per detected CRC of this strategy.

Methods: All individuals aged 60-69 invited to screening in 2015-2017 were included. Read More

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Cecal intubation time in screening colonoscopy.

Hyun Young Kim

Medicine (Baltimore) 2021 May;100(19):e25927

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.

Abstract: The time required to intubate the cecum varies. The aim of this study was to determine whether demographic and anthropometric factors, such as body mass index (BMI), percent body fat, muscle mass, and fat mass, affect the cecal intubation time (CIT) during complete colonoscopy.A retrospective chart review of 1229 patients (aged 40-80 years) was performed. Read More

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Very Early-Onset Inflammatory Bowel Disease (VEO-IBD) Presenting with Recurrent Leukocytoclastic Vasculitis Preceded by Streptococcal Pharyngitis.

Case Rep Pediatr 2021 20;2021:1996430. Epub 2021 May 20.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Nicklaus Children's Hospital, Miami, FL, USA.

Inflammatory bowel disease (IBD) that presents in children <6 years of age is known as very early-onset IBD (VEO-IBD). Extraintestinal manifestations in IBD, such as erythema nodosum (EN), pyoderma gangrenosum (PG), and, less likely, leukocytoclastic vasculitis (LV), are more commonly present in Crohn's disease. Association between LV and ulcerative colitis (UC) is not commonly seen. Read More

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Cloud-based multi-media systems for patient education and adherence: a pilot study to explore patient compliance with colonoscopy procedure preparation.

Health Syst (Basingstoke) 2019 Sep 12;10(2):89-103. Epub 2019 Sep 12.

Business/MIS, San Jose State University, San Jose, CA, USA.

Technology based patient education and adherence approaches are increasingly utilized to instruct and remind patients to prepare correctly for medical procedures. This study examines the interaction between two primary factors: patterns of patient adherence to challenging medical preparation procedures; and the demonstrated, measurable potential for cloud-based multi-media information technology (IT) interventions to improve patient adherence. An IT artifact was developed through prior design science research to serve information, reminders, and online video instruction modules to patients. Read More

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September 2019

Evaluation of a novel colonoscope offering flexibility adjuster - a retrospective observational study.

Therap Adv Gastroenterol 2021 30;14:17562848211013494. Epub 2021 May 30.

Interdisciplinary Endoscopy, First Medical Department, University Medical Center Mainz, Mainz, Germany.

Background: Although colonoscopy is the gold standard for colorectal cancer screening, colonic looping may make complete colonoscopy challenging. Commonly available stiffening device colonoscopy has been described as helpful but not effective enough to prevent looping. In this context the effect on cecal intubation time and rate was described differently in various studies and in some studies had no impact on cecal intubation time at all. Read More

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Does National Colorectal Cancer Screening Program Represent Good Value for Money? Results from a Return-on-Investment Model in Vietnam.

Health Serv Insights 2021 24;14:11786329211017418. Epub 2021 May 24.

Hanoi University of Public Health, Hanoi, Vietnam.

To provide important evidence for the resource allocation process in Vietnam, this research was conducted to explore the return on investment (ROI) of the national colorectal cancer (CRC) screening program. A decision tree model was designed to estimate the cost and cost savings of a national screening program (ie, providing annual fecal occult blood test [FOBT], following with colonoscopy in case of FOBT positive for the medium-risk group over 50 years old) compared to no screening scenario. This was the first attempt in estimating the ROI of a public health program in Vietnam. Read More

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Colorectal cancer Outcomes in people with Severe Mental Illness Cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data.

BMJ Open 2021 Jun 8;11(6):e044737. Epub 2021 Jun 8.

School of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia

Introduction: Colorectal cancer (CRC) mortality is significantly higher in those with severe mental illness (SMI) compared with the general population, despite similar incidence rates, suggesting that barriers to optimal screening and cancer care may contribute to disparities in CRC mortality in those with SMI. This study aims to compare participation in Australia's National Bowel Cancer Screening Programme (NBCSP) in those with SMI and those in the general population. We will also investigate treatment pathways after diagnosis to determine whether treatment variations could explain differences in CRC mortality. Read More

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Perilesional Lymph Node Swelling Might Be a Radiologic Clue for Appendiceal Schwannoma: A Case Report.

Curr Med Imaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.

Background: Gastrointestinal schwannoma is not a common type of tumor, and lesions originating from the appendix are extremely rare. Herein, we report a patient with appendiceal schwannoma characterized by lymph node swelling.

Case Report: A 67-year-old male patient who had diabetes complained of weight loss. Read More

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RNNSLAM: Reconstructing the 3D colon to visualize missing regions during a colonoscopy.

Med Image Anal 2021 May 19;72:102100. Epub 2021 May 19.

University of North Carolina at Chapel Hill, Chapel Hill, NC 27705, USA.

Colonoscopy is the gold standard for pre-cancerous polyps screening and treatment. The polyp detection rate is highly tied to the percentage of surveyed colonic surface. However, current colonoscopy technique cannot guarantee that all the colonic surface is well examined because of incomplete camera orientations and of occlusions. Read More

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Pyoderma gangrenosum with primary sclerosing cholangitis-associated colitis successfully treated with concomitant granulocyte and monocyte adsorption apheresis with corticosteroids.

Clin J Gastroenterol 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

An 18-year-old woman was admitted to our hospital with fever, diarrhea and painful skin ulcers in both pretibial areas starting 19 days earlier. The skin lesions appeared deep necrotic ulcers with violaceous undermined borders. She had been diagnosed as ulcerative colitis and primary sclerosing cholangitis (PSC) 6 and 5 years before, respectively, and had stopped having regular check-up and refused medication for years. Read More

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Repeat preoperative endoscopy after regional implementation of electronic synoptic endoscopy reporting: a retrospective comparative study.

Surg Endosc 2021 Jun 8. Epub 2021 Jun 8.

Department of Surgery, Section of General Surgery, University of Manitoba, Winnipeg, MB, Canada.

Background: Repeat preoperative endoscopy is common for patients with colorectal neoplasms. This can result in treatment delays, patient discomfort, and risks of colonoscopy-related complications. Repeat preoperative endoscopy has been attributed to poor communication between endoscopists and surgeons. Read More

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