42,697 results match your criteria Colonoscopy


[Choosing wisely - perspectives: what are the key questions?]

Authors:
Axel Holstege

Z Gastroenterol 2020 Jul 13;58(7):652-658. Epub 2020 Jul 13.

Gastroenterology offers a wide field for future "choosing wisely" recommendations (CWR). They should refer not only to an under- or overuse of diagnostic tools like laboratory or imaging tests but also to an evidence-based application of drug therapies und endoscopic interventions. Drugs like antibiotics or proton pump inhibitors are both often prescribed in the absence of clearly defined underlying diseases and not given when an indication is clear. Read More

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http://dx.doi.org/10.1055/a-1153-9295DOI Listing

Computer-assisted detection of diminutive and small colon polyps by colonoscopy using an extra-wide-area-view colonoscope.

Endoscopy 2020 Jul 13. Epub 2020 Jul 13.

Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1055/a-1202-1277DOI Listing

Endoscopic closure of a perforated rectum with an over-the-scope clip following diagnostic colonoscopy.

Endoscopy 2020 Jul 13. Epub 2020 Jul 13.

Department of Gastroenterology, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.1055/a-1198-4288DOI Listing

TNF-α, IL-17 AND IL-22 PRODUCTION IN THE RECTAL MUCOSA OF NON-CELIAC WHEAT SENSITIVITY PATIENTS: ROLE OF ADAPTIVE IMMUNITY.

Am J Physiol Gastrointest Liver Physiol 2020 Jul 13. Epub 2020 Jul 13.

Internal Medicine, Sciacca Hospital, and University of Palermo, Palermo, Italy., Italy.

In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS). NCWS pathogenesis is still uncertain and attributed to very different mechanisms. We aimed to study the different T lymphocyte subsets in the rectal mucosa of NCWS patients, to demonstrate the possible contribution of adaptative immune response. Read More

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http://dx.doi.org/10.1152/ajpgi.00104.2020DOI Listing

Adenosine Deaminase as a Useful Biomarker for Diagnosis and Monitoring of Inflammatory Bowel Disease.

Clin Lab 2020 Jul;66(7)

Background: Inflammatory bowel disease (IBD) is a multifactorial immunologically mediated disorder characterized by repeated cycles of exacerbations and remissions. Diagnosis and monitoring of ulcerative colitis (UC) and Crohn's disease (CD) as common types of IBD require the usage of unpleasant invasive methods such as colonoscopy and cross-sectional imaging. Development of a non-invasive biomarker panel including different inflammatory parameters for evaluation of various aspects of gut inflammation and disease course is a priority task. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.191124DOI Listing

Novel Inflammatory-Nutritional Biomarkers as Predictors of Histological Activity in Crohn's Disease.

Clin Lab 2020 Jul;66(7)

Background: There has increasingly been an interest in histological remission as a therapeutic endpoint in inflammatory bowel disease. The aim of this study was to evaluate the utility of a variety of inflammatory - nutritional markers for predicting histological disease activity in patients diagnosed with Crohn's disease.

Methods: Patients with Crohn's disease that had requisite endoscopic, pathological, and laboratory data were retrospectively enrolled in the study. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190816DOI Listing

Successful Treatment of Pseudomembranous Colitis with Fecal Microbiota Transplantation - A Case Study on A Patient Rescued by Extracorporeal Cardiopulmonary Resuscitation After Cardiac Arrest.

Ann Transplant 2020 Jul 1;25:e923283. Epub 2020 Jul 1.

Department of Intensive Care Unit, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).

BACKGROUND Pseudomembranous colitis (PMC) is an opportunistic, nosocomial infection caused by Clostridium difficile. CASE REPORT Here we described a patient who developed PMC during her recovery from cardiac arrest. A 16-year-old female high school student experienced sudden cardiac arrest. Read More

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http://dx.doi.org/10.12659/AOT.923283DOI Listing

Improved adenoma detection with linked color imaging technology compared to white-light colonoscopy.

Scand J Gastroenterol 2020 Jul 12:1-7. Epub 2020 Jul 12.

Endoscopy Unit, Endo-Kapszula Health Centre, Székesfehérvár, Hungary.

Objectives: Linked color imaging (LCI) is a new endoscopic technology that may increase colorectal adenoma detection rate (ADR) and polyp detection rate (PDR) by virtual chromoendoscopy. Aim of the present study was to evaluate the effectiveness of LCI in ADR and PDR compared to the HD white-light colonoscopy (WLC) technique.

Materials And Methods: Between October 2016 and June 2018, we enrolled consecutive outpatients prospectively. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786850DOI Listing

Combined endo-laparoscopic surgery for difficult benign colorectal polyps.

J Gastrointest Oncol 2020 Jun;11(3):475-485

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China.

Prevention of colorectal cancer (CRC) depends largely on the detection and removal of colorectal polyps. Despite the advances in endoscopic techniques, there are still a subgroup of polyps that cannot be treated purely by endoscopic approach, which comprise of about 10-15% of all the polyps. These so-called "difficult colorectal polyps" are polyps with large size, morphology, at difficult location, scarring or due to recurrence, which have historically been managed by surgical segmental resection. Read More

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http://dx.doi.org/10.21037/jgo.2019.12.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340814PMC

Corrigendum to "The Effectiveness, Tolerability, and Safety of Different 1-Day Bowel Preparation Regimens for Pediatric Colonoscopy".

Gastroenterol Res Pract 2020 18;2020:9126957. Epub 2020 Jun 18.

Department of Pediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

[This corrects the article DOI: 10.1155/2019/3230654.]. Read More

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http://dx.doi.org/10.1155/2020/9126957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320278PMC

Fecal immunological test results and diagnostic colonoscopy in a Mexican population at average risk for colorectal cancer.

Cancer Prev Res (Phila) 2020 Jul 12. Epub 2020 Jul 12.

Instituto Nacional de Cancerología

Colorectal cancer(CRC) is preventable and treatable by screening and early detection. Fecal immunochemical tests(FIT) for average risk individuals is an effective strategy for screening. Incidence and mortality in Mexico is increasing and large-scale screening programs do not yet exist. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-20-0076DOI Listing

Metabolomics Analysis of Aspirin's Effects in Human Colon Tissue and Associations with Adenoma Risk.

Cancer Prev Res (Phila) 2020 Jul 12. Epub 2020 Jul 12.

Emory University.

Although substantial evidence supports aspirin's efficacy in colorectal cancer chemoprevention, key molecular mechanisms are uncertain. An untargeted metabolomics approach with high-resolution mass spectrometry was used to elucidate metabolic effects of aspirin treatment in human colon tissue. We measured 10,269 metabolic features in normal mucosal biopsies collected at colonoscopy after approximately three years of randomized treatment with placebo, 81 mg/day or 325 mg/day aspirin from 325 participants in the Aspirin/Folate Polyp Prevention Study. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-20-0014DOI Listing

Fruit and vegetable consumption is associated with lower prevalence of asymptomatic diverticulosis: a cross-sectional colonoscopy-based study.

BMC Gastroenterol 2020 Jul 11;20(1):221. Epub 2020 Jul 11.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.

Background: Previous studies of the relationship between dietary factors and risk of diverticulosis have yielded inconsistent results. We therefore sought to investigate the association between consumption of fruit and vegetables and prevalent diverticulosis.

Methods: Our study population included participants in the Gastrointestinal Disease and Endoscopy Registry (GIDER), a colonoscopy-based longitudinal cohort at the Massachusetts General Hospital, who provided comprehensive information on dietary intake and lifestyle factors using validated questionnaires prior to colonoscopy. Read More

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http://dx.doi.org/10.1186/s12876-020-01374-0DOI Listing

A stuck colonoscope in the chest cavity: An uncommon complication.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiothoracic Surgery, Basildon and Thurrock University Hospitals, Basildon, UK.

Colonoscopy is generally considered a safe procedure, with a low rate of complications. Although rare, the migration of the colonoscope may represent life-threatening events, requiring emergency treatment. We, herein, describe the case of an elective colonoscopy complicated by an irretrievable colonoscope that migrated, through a previous traumatic diaphragmatic hernia, in the chest cavity. Read More

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http://dx.doi.org/10.1111/jocs.14750DOI Listing

First case of serrated lesion of the duodenal papilla in a patient with serrated colonic polyposis.

Clin Res Hepatol Gastroenterol 2020 Jul 7. Epub 2020 Jul 7.

Sorbonne Université, Endoscopy Unit, AP-HP, Hôpital Saint-Antoine, 75012 Paris, France.

A serrated polyposis syndrome was diagnosed in a 26-year-old female presenting with gastrointestinal symptoms. Screening for other lesions of the gastrointestinal tract showed a serpiginous looking papilla, described as possibly dysplastic. Histological analysis of biopsies showed a serrated lesion. Read More

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http://dx.doi.org/10.1016/j.clinre.2020.06.010DOI Listing

Colonoscopic techniques in polyp detection: An Egyptian study.

Rev Gastroenterol Mex 2020 Jul 7. Epub 2020 Jul 7.

Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, Egipto. Electronic address:

Introduction And Aims: The polyp detection rate (PDR) is defined as the percentage of colonoscopies in which one or more polyps are detected, and has been shown to be highly correlated with the adenoma detection rate. The aim of the present study was to evaluate the PDR at the Endoscopy Unit of the Kasr Al-Ainy Hospital, Cairo University, Egypt, through the i-SCAN, Endocuff, and underwater colonoscopy techniques.

Materials And Methods: The study was conducted on 100 Egyptian subjects over 50 years of age. Read More

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http://dx.doi.org/10.1016/j.rgmx.2020.02.004DOI Listing

Colonoscopy Screening Behaviour and Associated Factors Amongst First-Degree Relatives of People with Colorectal Cancer in China: Testing the Health Belief Model Using a Cross-Sectional Design.

Int J Environ Res Public Health 2020 Jul 8;17(14). Epub 2020 Jul 8.

The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.

Colonoscopy is the best screening choice for at-risk persons, because it offers prevention through the removal of preneoplastic lesions in addition to early detection. This study aims to report the participation rate of colonoscopy screening and examine its associated factors amongst Chinese first-degree relatives of people with colorectal cancer based on the health belief model (HBM). A cross-sectional study was conducted in Shenzhen, China from March to May 2019. Read More

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http://dx.doi.org/10.3390/ijerph17144927DOI Listing

Adding efficiency to proficiency: a study of trainee polypectomy efficiency metrics.

Endoscopy 2020 Jul 10. Epub 2020 Jul 10.

Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.

Background:  Although validated colonoscopy assessment tools exist, they do not measure efficiency. This study aimed to assess content validity of polypectomy efficiency (PE) and neoplastic polypectomy efficiency (NPE) as colonoscopy efficiency indices.

Methods:  Data from a randomized controlled trial evaluating polypectomy among gastroenterology trainees were utilized. Read More

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http://dx.doi.org/10.1055/a-1192-4250DOI Listing

Increased Sessile Serrated Adenoma Detection Rate With Mechanical New Technology Devices: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2020 Jul 8. Epub 2020 Jul 8.

Division of Gastroenterology, New York VA Harbor Healthcare, NYU School of Medicine, New York, NY.

Goal: This meta-analysis aims to compare the sessile-serrated adenoma detection rate (SSADR) of currently available mechanical new technology devices (NTDs) to conventional colonoscopy (CC).

Background: NTDs including Endocuff, EndoRing, G-Eye, and AmplifEYE were developed with the aim of improving adenoma detection rate by enhancing colonic mucosal visualization. Increasing awareness of the risk of sessile-serrated adenoma progression to malignancy has ushered a need to increase the detection of these characteristically flat lesions. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001363DOI Listing

Colopancreatic Fistula Following Screening Colonoscopy.

ACG Case Rep J 2020 Jun 22;7(6):e00406. Epub 2020 Jun 22.

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.14309/crj.0000000000000406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310854PMC

FDG-PET Versus PSMA-PET: A Patient With Prostate Cancer.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941313

Westchester Medical Center, Valhalla, NY, USA.

A 64-year old male presented to the hospital with a 1-week history of stools with bright red blood. Subsequent colonoscopy with a biopsy revealed a low-lying, moderately differentiated, rectal adenocarcinoma. A pelvic magnetic resonance imaging done afterwards showed a possible T3N1 rectal cancer with intact muscularis mucosa and a singular presacral lymph node enlargement. Read More

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http://dx.doi.org/10.1177/2324709620941313DOI Listing

Fecal Microbiota Transplantation is Safe and Effective in Patients with Clostridioides difficile Infection and Cirrhosis.

Clin Gastroenterol Hepatol 2020 Jul 6. Epub 2020 Jul 6.

Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Background & Aims: Clostridioides difficile infection (CDI) harms a large proportion of patients with cirrhosis. Fecal microbiota transplantation (FMT) is recommended for recurrent CDI, but its effects in patients with cirrhosis have not been established. We performed a multicenter, observational study to evaluate efficacy and safety of FMT for CDI in patients with cirrhosis. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.051DOI Listing

Feasibility of Patient Navigation and Impact on Adherence to Screening Colonoscopy in a Large Diverse Urban Population.

J Racial Ethn Health Disparities 2020 Jul 8. Epub 2020 Jul 8.

Memorial Sloan Kettering Cancer Center, Department of Medicine, 1275 York Avenue, New York, NY, 10065, USA.

Introduction: Disparities observed in colorectal cancer (CRC) incidence and mortality among blacks and Hispanics compared with whites may be in part due to lower screening rates. The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has implemented a patient navigator (PN) program at NYC hospitals serving lower-income patients to promote high adherence by patients referred for screening colonoscopy. A prior study showed this PN program increased adherence at 3 public hospitals. Read More

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http://dx.doi.org/10.1007/s40615-020-00812-9DOI Listing

Metastatic Gastric Signet Ring Cell Adenocarcinoma Presenting With Colonic Stenosis.

Cureus 2020 Jun 3;12(6):e8420. Epub 2020 Jun 3.

Gastroenterology, University Medical Centre Ljubljana, Ljubljana, SVN.

Metastases to the colon are rare and may mimic other diseases such as inflammatory bowel disease. This differential diagnosis is often overlooked by endoscopists which leads to unnecessary diagnostic delay or inappropriate treatment. We present a case of a 54-year-old woman who presented with ascites. Read More

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http://dx.doi.org/10.7759/cureus.8420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336610PMC

Non-tuberculous Mycobacterial Pseudo-outbreak of an Intestinal Culture Specimen Caused by a Water Tap in an Endoscopy Unit.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine, Division of Gastroenterology and Hepatology,, St. Marianna University School of Medicine, Japan.

Objective Gastrointestinal lesions of non-tuberculous mycobacteria (NTM) are regarded as opportunistic infections. A large number of positive specimens of NTM were identified in an intestinal fluid culture in the endoscopy unit and it was considered to be a pseudo-outbreak. Methods We reviewed the hospital, laboratory, and colonoscopy records of 263 consecutive patients whose intestinal fluids were analyzed for a mycobacterial culture by colonoscopy at St. Read More

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http://dx.doi.org/10.2169/internalmedicine.5188-20DOI Listing

Melanosis Coli Due to Aloe Vera Consumption.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

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http://dx.doi.org/10.2169/internalmedicine.5183-20DOI Listing

Salicylate use: a negative predictive factor for finding pathology explanatory for iron deficiency anaemia.

Neth J Med 2020 Jul;78(4):161-166

Department of Internal Medicine, Treant Healthcare, hospital location Scheper, Emmen, the Netherlands.

Purpose: To determine whether the use of salicylates is a predictive factor for detecting explanatory pathology during gastroscopy or colonoscopy procedures in patients with iron deficiency anaemia (IDA).

Methods: This retrospective study included patients who underwent a gastroscopy and/or a colonoscopyto determine the cause of IDA at Treant Healthcare, hospital location Scheper in Emmen, the Netherlands, between 2010 and 2016. The study compared two groups. Read More

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A prospective study of erythrocyte polyunsaturated fatty acids and risk of colorectal serrated polyps and conventional adenomas.

Int J Cancer 2020 Jul 7. Epub 2020 Jul 7.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three U.S. Read More

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http://dx.doi.org/10.1002/ijc.33190DOI Listing

Beyond Resettlement: Sociocultural Factors Influencing Breast and Colorectal Cancer Screening Among Afghan Refugee Women.

J Cancer Educ 2020 Jul 7. Epub 2020 Jul 7.

School of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.

Immigrants and refugees have an increased risk for developing chronic health conditions, such as breast and colorectal cancer, the longer they reside in the USA. Moreover, refugees are less even likely to use preventive health services like mammography and colonoscopy screening when compared with US-born counterparts. Focused ethnography was employed to examine sociocultural factors that influenced cancer screening behaviors among aging Afghan refugee women. Read More

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http://dx.doi.org/10.1007/s13187-020-01822-1DOI Listing

Economic evaluation of Faecal microbiota transplantation compared to antibiotics for the treatment of recurrent infection.

EClinicalMedicine 2020 Jul 27;24:100420. Epub 2020 Jun 27.

Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, United Kingdom.

Background: infection (CDI) is a hospital acquired disease associated with significant morbidity, hospitalisation and mortality. Almost 30% of treated patients experience at least one recurrence after treatment of their first episode. Treatment of recurrent CDI (rCDI) utilises vancomycin or fidaxomicin, however, a newer treatment option is faecal microbial transplantation (FMT) administered by nasogastric tube (NGT) or colonoscopy. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327885PMC

High Incidence of Burst Suppression during Propofol Sedation for Outpatient Colonoscopy: Lessons Learned from Neuromonitoring.

Anesthesiol Res Pract 2020 19;2020:7246570. Epub 2020 Jun 19.

Department of Anesthesiology, Division of Neurological Anesthesia, Thomas Jefferson University, 111 S. 11 Street, Philadelphia, PA 19107, USA.

Background: Although anesthesia providers may plan for moderate sedation, the depth of sedation is rarely quantified. Using processed electroencephalography (EEG) to assess the depth of sedation, this study investigates the incidence of general anesthesia with variable burst suppression in patients receiving propofol for outpatient colonoscopy. The lessons learned from neuromonitoring can then be used to guide institutional best sedation practice. Read More

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http://dx.doi.org/10.1155/2020/7246570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321500PMC

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes.

Public Health 2020 Jul 4;185:153-158. Epub 2020 Jul 4.

Institute for Clinical and Experimental Medicine, Department of Gastroenterology and Hepatology, Prague, Czech Republic.

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation.

Study Design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.05.021DOI Listing

Conventional Computed Tomographic Calcium Scoring vs full chest CTCS for lung cancer screening: a cost-effectiveness analysis.

BMC Pulm Med 2020 Jul 6;20(1):187. Epub 2020 Jul 6.

Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Background: Conventional CTCS images the mid/lower chest for coronary artery disease (CAD). Because many CAD patients are also at risk for lung malignancy, CTCS often discovers incidental pulmonary nodules (IPN). CTCS excludes the upper chest, where malignancy is common. Read More

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http://dx.doi.org/10.1186/s12890-020-01221-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336401PMC

Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy.

Korean J Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rarely examined. We evaluated the association between NAFLD and the development of metachronous CRN after polypectomy. Read More

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http://dx.doi.org/10.3904/kjim.2019.360DOI Listing

Inspection and polypectomy during both insertion and withdrawal or only during withdrawal of colonoscopy?: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Jul;99(27):e20775

Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: Current evidence supporting additional inspection and polypectomy during insertion of colonoscopy is limited. We plan to provide a systematic review and meta-analysis to compare the yield of inspection and polypectomy during both insertion and withdrawal versus the traditional practice of inspection and polypectomy during withdrawal only.

Methods And Analysis: Randomised controlled trials evaluating inspection and polypectomy during both insertion and withdrawal versus inspection and polypectomy during withdrawal only will be searched in MEDLINE, EMBASE, Web of Science, the Cochrane Library, ClinicalTrials. Read More

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http://dx.doi.org/10.1097/MD.0000000000020775DOI Listing

PREVALENCE AND CHARACTERISTICS OF ABDOMINAL PAIN IN THE UNITED STATES.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA; Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA; Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA; Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA. Electronic address:

Background & Aims: Abdominal pain is the most common gastrointestinal symptom reported in ambulatory clinics, but little is known about its prevalence and burden of illness in the general community. We conducted a population-based survey to determine the epidemiology, clinical characteristics, and healthcare-seeking behavior of persons with abdominal pain.

Methods: Using an online survey research firm, we recruited a representative sample of adults (18 years or older) with a history of abdominal pain. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.065DOI Listing
July 2020
7.896 Impact Factor

Virtual reality distraction for patients to relieve pain and discomfort during colonoscopy.

Endosc Int Open 2020 Jul 30;8(7):E959-E966. Epub 2020 Jun 30.

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, the Netherlands.

Colonoscopy is an invasive procedure that may cause patients pain and discomfort. Routine use of sedation, while effective, is expensive and requires logistical planning. Virtual reality (VR) offers immersive, three-dimensional experiences that distract the attention and might comfort patients. Read More

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http://dx.doi.org/10.1055/a-1178-9289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326580PMC

Association between Vitamin D Receptor Single-Nucleotide Polymorphisms and Colorectal Cancer in the Thai Population: A Case-Control Study.

Biomed Res Int 2020 15;2020:7562958. Epub 2020 Jun 15.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucleotide polymorphisms (SNPs), I, I, I, I, and I, with the risk of several cancers, including colorectal cancers. However, these associations vary among different populations. Read More

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http://dx.doi.org/10.1155/2020/7562958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313039PMC

Implementing visual cues to improve the efficacy of screening colonoscopy: exploiting the Hawthorne effect.

Ann Gastroenterol 2020 Jul-Aug;33(4):374-378. Epub 2020 May 10.

Division of Gastroenterology and Hepatology, SBH Health System, New York (Eric Omar Then, Christopher Brana, Sriharsha Dadana, Srikanth Maddika, Sabrina Brana, Tina Wexler, Andrea Culliford, Vinaya Gaduputi).

Background: Colonoscopy is the gold standard for colon cancer screening. Adenoma detection rate and a withdrawal time of 6 min are quality metrics to measure the efficacy of colonoscopy in colon cancer screening. The aim of our study was to exploit the Hawthorne effect in an effort to ensure adherence to a minimum 6-min withdrawal time and subsequently increase adenoma detection rate. Read More

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http://dx.doi.org/10.20524/aog.2020.0491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315716PMC

Barriers to Colorectal Cancer Screening for people with spinal cord injuries and/or disorders: A qualitative study.

Disabil Health J 2020 Jun 18:100950. Epub 2020 Jun 18.

Department of Population Health, University of Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.

Background: Limited research has shown people with spinal cord injuries and/or disorders (SCID) are less likely to be up to date with colorectal cancer (CRC) screening and therefore more likely to be diagnosed with advanced stage CRC compared to people without SCID.

Objective: The aims of this study were to assess knowledge about CRC, CRC screening, and self-reported barriers to CRC screening for people with SCID.

Methods: Interviews with 30 individuals with SCID were conducted using a semi-structured interview guide, audio recorded, and transcribed. Read More

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http://dx.doi.org/10.1016/j.dhjo.2020.100950DOI Listing

ACE (Angiotensin-Converting Enzyme) Inhibitors/Angiotensin Receptor Blockers Are Associated With Lower Colorectal Cancer Risk: A Territory-Wide Study With Propensity Score Analysis.

Hypertension 2020 Jul 6:HYPERTENSIONAHA12015317. Epub 2020 Jul 6.

From the Department of Medicine, The University of Hong Kong, Queen Mary Hospital (K.S.C., W.K.S., W.K.L.).

Whether ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers modify colorectal cancer risk remains controversial. We aimed to determine association between their use and colorectal cancer risk after a negative baseline colonoscopy. This is a territory-wide retrospective cohort study recruiting patients aged ≥40 who had undergone colonoscopy between 2005 and 2013. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15317DOI Listing

Effect of Behavioral Economic Incentives for Colorectal Cancer Screening in a Randomized Trial.

Clin Gastroenterol Hepatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania; Center for Health Care Innovation, University of Pennsylvania; Center for Health Incentives and Behavioral Economics, University of Pennsylvania; Center for Health Equity Research and Promotion, Philadelphia VA Medical Center.

Background & Aims: Financial incentives might increase participation in prevention such as screening colonoscopy. We studied whether incentives informed by behavioral economics increase participation in risk assessment for colorectal cancer (CRC) and completion of colonoscopy for eligible adults.

Methods: Employees of a large academic health system (50-64 y old; n=1977) were randomly assigned to groups that underwent risk assessment for CRC screening and direct access colonoscopy scheduling (control), or risk assessment, direct access colonoscopy scheduling, a $10 loss-framed incentive to complete risk assessment, and a $25 unconditional incentive for colonoscopy completion (incentive). Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.047DOI Listing

Quantitative Assessment of Radiologically Indeterminate Local Colonic Wall Thickening on Iodine Density Images Using Dual-Layer Spectral Detector CT.

Acad Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China.

Rationale And Objectives: To assess local colonic wall thickening (LCWT, thicknesses: >3 mm, lengths: <5 cm) quantitatively on iodine density images using dual-layer spectral detector computed tomography (DLSCT).

Materials And Methods: This retrospective study included 80 patients who underwent both conventional contrast-enhanced CT and colonoscopy within one month. The region of interest was delineated on the chosen images with the iodine density image model. Read More

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http://dx.doi.org/10.1016/j.acra.2020.06.012DOI Listing
July 2020
2.077 Impact Factor

Delays in colonoscopy start time are associated with reductions in adenoma detection rates.

Dig Liver Dis 2020 Jul 1. Epub 2020 Jul 1.

Celiac Disease Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

Background: Prior investigations of the impact of case delays on adenoma detection rates have not found a significant association, though these studies included modest delays, with few cases delayed by more than one hour.

Aims: The aim of this study was to measure the impact of prolonged case delays on the colonoscopy outcome measures of adenoma detection rate and withdrawal time.

Methods: We performed a single center cohort study including patients aged ≥50 years undergoing screening colonoscopy during a 4. Read More

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http://dx.doi.org/10.1016/j.dld.2020.06.011DOI Listing

THE COURAGE TO RETURN TO EVERYDAY LIFE AT THE TIME OF COVID-19: THE POINT OF VIEW OF INFLAMMATORY BOWEL DISEASE PATIENTS NEEDING ENDOSCOPY.

Gastroenterology 2020 Jul 1. Epub 2020 Jul 1.

Gastroenterology and Endoscopy Unit, ARNAS Civico - Di Cristina - Benfratelli Hospital, Palermo, Italy.

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http://dx.doi.org/10.1053/j.gastro.2020.06.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328535PMC

Synchronous Primary Pancreatic Ductal Carcinoma and Colonic Adenocarcinoma Present in a Patient With History of Skin Squamous Cell Carcinoma.

Anticancer Res 2020 Jul;40(7):4029-4032

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

The synchronous diagnosis of two or more primary malignancies in a patient is overall rare. This is a case report of a 70-year-old female with a history of skin squamous cell carcinoma presenting with occult hematochezia. Colonoscopy and biopsy results confirmed a microsatellite stable (MMS) adenocarcinoma in the ascending colon, and subsequent computed tomography (CT) scans identified a 3. Read More

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http://dx.doi.org/10.21873/anticanres.14398DOI Listing

Standardising Robotic TransAnal Minimal Invasive Surgery (R-TAMIS) in lithotomy using the Xi platform - a video vignette.

Colorectal Dis 2020 Jul 3. Epub 2020 Jul 3.

Epworth Eastern Hospital, 1 Arnold Street, Box Hill, Victoria, Australia, 3128.

A 47-year-old male presented with chronic diarrhoea, colonoscopy revealed a pedunculated, broad-based, 3cm, mid-rectal polyp. An R-TAMIS was booked. This video vignette demonstrates a standardised R-TAMIS in lithotomy using the da Vinci Xi platform. Read More

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http://dx.doi.org/10.1111/codi.15224DOI Listing

Risk-Adapted Cutoffs in Colorectal Cancer Screening by Fecal Immunochemical Tests.

Am J Gastroenterol 2020 Jul;115(7):1110-1116

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Fecal immunochemical tests (FITs) for hemoglobin are increasingly used in colorectal cancer (CRC) screening. The use of uniform positivity thresholds (cutoffs) within screening populations is expected to imply lower positive predictive values (PPVs) and higher numbers of colonoscopies needed (numbers needed to scope [NNSs]) to detect advanced neoplasms among screening participants at lower risk compared with those at higher risk. We aimed to assess such variation and its potential implications in a large screening cohort. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000579DOI Listing

Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden.

Am J Gastroenterol 2020 Jul;115(7):980-988

Division of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Advanced adenomas represent a subset of colorectal polyps that are known to confer an increased risk of colorectal neoplasia to the affected individual and their first-degree relatives (FDRs). Accordingly, professional guidelines suggest earlier and more intensive screening for FDRs of those with advanced adenomas similar to FDRs of those with colorectal cancer (CRC). Although the risk to family members is less clear among patients with advanced serrated polyps, they are often considered in the same category. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000639DOI Listing