14,082 results match your criteria Colonic Polyps


The Efficacy of Split-Dose Bowel Preparations for Polyp Detection: A Systematic Review and Meta-Analysis.

Am J Gastroenterol 2019 Mar 11. Epub 2019 Mar 11.

Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Split-dose bowel preparation leads to superior colon cleansing for colonoscopy. However, the magnitude of benefit in detecting colonic polyps is uncertain. We performed a systematic review to synthesize the data on whether using a split-dose bowel preparation regimen improves the detection of polyps when compared with other dosing methods or regimen products. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000155DOI Listing

Detection rate of colonic polyp among patients who had undergone colonoscopy at gastroenterology unit of Serdang Hospital, Malaysia.

Med J Malaysia 2019 Feb;74(1):20-24

Putra University of Malaysia, Faculty of Medicine and Health Sciences, Medical Department, Selangor, Malaysia.

Objective: The aim of this study was to evaluate the demography, and to determine the detection rate of polyps, and detection rate of adenoma at a Malaysian tertiary hospital.

Methods: This is a retrospective study of all the patients who had undergone colonoscopy at Gastroenterology endoscopy unit, Serdang Hospital from 1st January 2010 to 31st December 2016. Patients who had a history of colorectal cancer, polyp or inflammatory bowel disease were excluded. Read More

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February 2019

A randomized controlled study of the prediction of diminutive/small colorectal polyp histology using didactic vs. computer based self-learning module in gastroenterology trainees.

Dig Endosc 2019 Mar 7. Epub 2019 Mar 7.

Institute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, UK.

Background And Aim: The aim of this randomised trial was to evaluate the performance of self-training vs. didactic training, to increase the diagnostic accuracy of diminutive/small colonic polyp histological prediction by trainees.

Methods: Sixteen trainees reviewed 78 videos (48 iSCAN-OE and 30 NBI) of diminutive/small polyps in a pre-training assessment. Read More

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http://doi.wiley.com/10.1111/den.13389
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http://dx.doi.org/10.1111/den.13389DOI Listing
March 2019
2 Reads

Fisher encoding of convolutional neural network features for endoscopic image classification.

J Med Imaging (Bellingham) 2018 Jul 24;5(3):034504. Epub 2018 Sep 24.

University of Salzburg, Department of Computer Sciences, Salzburg, Austria.

We propose an approach for the automated diagnosis of celiac disease (CD) and colonic polyps (CP) based on applying Fisher encoding to the activations of convolutional layers. In our experiments, three different convolutional neural network (CNN) architectures (AlexNet, VGG-f, and VGG-16) are applied to three endoscopic image databases (one CD database and two CP databases). For each network architecture, we perform experiments using a version of the net that is pretrained on the ImageNet database, as well as a version of the net that is trained on a specific endoscopic image database. Read More

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http://dx.doi.org/10.1117/1.JMI.5.3.034504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152583PMC
July 2018
1 Read

Complete endoscopic mucosal resection of malignant colonic sessile polyps and clinical outcome of 51 cases.

Ann Gastroenterol 2019 Mar-Apr;32(2):174-177. Epub 2018 Dec 21.

Department of Gastroenterology (Maria Fragaki, Evangelos Voudoukis, Ioannis Dimas, Afroditi Mpitouli, Magdalini Velegraki, Emmanouil Vardas, Angeliki Theodoropoulou, Konstantinos Karmiris, Gregorios Paspatis), Venizeleion General Hospital, Heraklion, Greece.

Background: Meta-analyses and guidelines recommend that deep submucosal invasion (>1 mm) of malignant sessile colonic polyps is an important risk factor for lymph node metastasis. However, existing data are based on small retrospective studies with marked heterogeneity. We herein aimed to investigate the long-term outcomes of patients who underwent complete endoscopic mucosal resection (EMR) of malignant colonic sessile polyps invading the submucosal layer. Read More

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http://dx.doi.org/10.20524/aog.2018.0343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394258PMC
December 2018
1 Read

Mouse model of 'Mutated in Colorectal Cancer' gene deletion reveals novel pathways in inflammation and cancer.

Cell Mol Gastroenterol Hepatol 2019 Mar 1. Epub 2019 Mar 1.

Garvan Institute of Medical Research, Sydney, NSW, Australia; School of Medicine, Western Sydney University, Sydney, NSW, Australia; Microbiome Research Centre, St George & Sutherland Clinical School, UNSW Sydney, Sydney, NSW, Australia. Electronic address:

Background & Aims: The early events by which inflammation promotes cancer are still not fully defined. 'Mutated in colorectal cancer' (MCC) gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here we aimed to determine the impact of Mcc deletion on the cellular pathways and carcinogenesis associated with inflammation in the mouse proximal colon. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.01.009DOI Listing
March 2019
1 Read

Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients.

Gut 2019 Feb 26. Epub 2019 Feb 26.

Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

Background And Aims: Postcolonoscopy colorectal cancer (PCCRC) accounts for up to 9% of all CRCs. Statins have been shown to be associated with a lower CRC risk. We aimed to investigate whether PCCRC risk was also lower among statin users. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317714DOI Listing
February 2019
1 Read

Domain-Based Analysis of Colon Polyp in CT Colonography Using Image-Processing Techniques

Asian Pac J Cancer Prev 2019 Feb 26;20(2):629-637. Epub 2019 Feb 26.

Department of Computer Science and Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India. Email:

Background: The purpose of the research was to improve the polyp detection accuracy in CT Colonography (CTC) through effective colon segmentation, removal of tagged fecal matter through Electronic Cleansing (EC), and measuring the smaller polyps. Methods: An improved method of boundary-based semi-automatic colon segmentation with the knowledge of colon distension, an adaptive multistep method for the virtual cleansing of segmented colon based on the knowledge of Hounsfield Units, and an automated method of smaller polyp measurement using skeletonization technique have been implemented. Results: The techniques were evaluated on 40 CTC dataset. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.629DOI Listing
February 2019
1 Read

Salivary Glycine Is a Significant Predictor for the Attenuation of Polyp and Tumor Microenvironment Formation by Fucoxanthin in AOM/DSS Mice.

In Vivo 2019 Mar-Apr;33(2):365-374

Epidemiology and Preventions Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Background/ Aim: A high polar xanthophyll of Fucoxanthin (Fx) is abundantly contained in edible brown algae, and it has chemopreventive effects in mouse cancer models, however, the underlying mechanisms of these effects are not well understood. Thus, we aimed to investigate the effects of Fx on the tumor microenvironment in cancer model mice.

Materials And Methods: We investigated the effect of Fx (30 mg/kg body weight) in a variety of cell types within the tumor microenvironment of α mouse preclinical colorectal cancer model and analyzed the mouse saliva in search of predictors for cancer chemopreventive effects. Read More

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http://dx.doi.org/10.21873/invivo.11483DOI Listing
December 2018

Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection.

Biomed Opt Express 2019 Feb 24;10(2):838-854. Epub 2019 Jan 24.

Department of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor, MI 48109, USA.

We developed and applied rapid scanning laser-emission microscopy (LEM) to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors. Regulation of chromatins is essential for genetic development and normal cell functions, while abnormal nuclear changes may lead to many diseases, in particular, cancer. The capability to detect abnormal changes in "apparently normal" tissues at a stage earlier than tumor development is critical for cancer prevention. Read More

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http://dx.doi.org/10.1364/BOE.10.000838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377874PMC
February 2019
2 Reads

The value of using fludeoxyglucose positron-emission tomography scan with respect to colorectal abnormalities-a cross-sectional study.

J Gastrointest Oncol 2019 Feb;10(1):1-5

Department of Gastroenterology and Nuclear Medicine, Zaans Medisch Centrum, Zaandam, The Netherlands.

Background: Fludeoxyglucose positron-emission tomography (FDG-PET) shows colic uptake regularly. Complementary colonoscopy is done. Aim: study the findings of colonoscopy. Read More

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http://dx.doi.org/10.21037/jgo.2018.09.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351306PMC
February 2019
1 Read

POTENTIAL PREVENTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS PLANTARUM IN PATIENTS WITH POLYPS OR COLORECTAL CÂNCER.

Arq Gastroenterol 2018 Oct-Dec;55(4):407-411

Alborz University of Medical Sciences, School of Medicine, Department of Microbiology, Karaj, Iran.

Background: Colorectal cancer is one of the major causes of death worldwide. Many studies have been done on the biology of its formation as well as its treatment in recent years. One of the factors involved in the formation or treatment of this malignancy can be attributed to the microbial flora in the intestine. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-87DOI Listing
March 2019
1 Read

BEST POLYPECTOMY TECHNIQUE FOR SMALL AND DIMINUTIVE COLORECTAL POLYPS: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Oct-Dec;55(4):358-368

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Serviço de Endoscopia Gastrointestinal, São Paulo, SP, Brasil.

Background: Polypectomy of colorectal polyps is the mainstay of colorectal cancer prevention. Identification of the best polypectomy technique is imperative.

Objective: This review aims at comparing efficacy of nine different resection methods for small colorectal polyps (<10 mm). Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-79DOI Listing

Endoscopic diagnosis of colorectal polyps with the use of blue-light imaging: For experts only?

Gastrointest Endosc 2019 03;89(3):655-656

Gastroenterology Department, Cochin Hospital, Paris, France; Paris Descartes University, Paris, France.

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http://dx.doi.org/10.1016/j.gie.2018.11.002DOI Listing

Look, but don't touch: what not to do in managing large colorectal polyps.

Gastrointest Endosc 2019 03;89(3):479-481

University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.gie.2018.10.008DOI Listing
March 2019
1 Read
5.369 Impact Factor

Large desmoid tumors in familial adenomatous polyposis: a successful outcome.

Autops Case Rep 2018 Oct-Dec;8(4):e2018045. Epub 2018 Sep 26.

Centro Hospitalar de São João, Department of Surgery. Porto, Portugal.

Desmoid tumors develop from connective tissue, fasciae, and aponeuroses, and may occur in the context of familial adenomatous polyposis or may arise sporadically; also, they may be extra-abdominal, intra-abdominal, or located in the abdominal wall. These benign tumors have a great aggressiveness with a high rate of local recurrence. Familial adenomatous polyposis is an inherited condition with autosomal dominant transmission, and is characterized by the development of multiple colonic and rectal adenomatous polyps, as well as desmoid tumors. Read More

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http://dx.doi.org/10.4322/acr.2018.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360820PMC
September 2018

Colonic adenoma-associated Escherichia coli express specific phenotypes.

Microbes Infect 2019 Feb 11. Epub 2019 Feb 11.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy; Dani Di Giò Foundation-Onlus, Rome, Italy. Electronic address:

Specific Escherichia coli strains have been associated to colorectal cancer, while no data are available on genotypic and phenotypic features of E. coli colonizing premalignant adenomatous polyps and their pathogenic potential. This study was aimed at characterizing isolates collected from polyps and adjacent tissue in comparison with those from normal mucosa. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.02.001DOI Listing
February 2019
1 Read

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Colorectal Cancer Biomarkers - A New Trend in Early Diagnosis.

Curr Health Sci J 2018 Apr-Jun;44(2):140-146. Epub 2018 Mar 27.

Ist Clinic of Surgery, Emergency Clinic County Hospital of Craiova, Romania.

Colorectal cancer (CRC) is one of the most widespread malignancy, posing as a great challenge due to its high incidence and mortality in both genders. Yet, it also stands as one of the most preventable diseases because of its known malignant transformation mostly from tubular adenomas or serrated polyps, therefore offering a strong incentive to the screening programs that are being developed for this disease. Current diagnosis of CRC has surely evolved along with the evolutionary step in gastrointestinal technology of flexible endoscopy. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320460PMC
March 2018
4 Reads

Disagreement between high confidence endoscopic adenoma prediction and histopathological diagnosis in colonic lesions ≤ 3 mm in size.

Endoscopy 2019 Mar 5;51(3):221-226. Epub 2019 Feb 5.

Division of Gastroenterology and Hepatology, Indiana University, School of Medicine, Indianapolis, Indiana, United States.

Background:  Diminutive colorectal polyps resected during colonoscopy are sometimes histologically interpreted as normal tissue. The aim of this observational study was to explore whether errors in specimen handling or processing account in part for polyps ≤ 3 mm in size being interpreted as normal tissue by pathology when they were considered high confidence adenomas by an experienced endoscopist at colonoscopy.

Methods:  One endoscopist photographed 900 consecutive colorectal lesions that were ≤ 3 mm in size and considered endoscopically to be high confidence conventional adenomas. Read More

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http://dx.doi.org/10.1055/a-0831-2348DOI Listing
March 2019
2 Reads

[Clinicopathological features of non-neoplastic colorectal polyps].

Authors:
L Jiang Y F Jiao

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):98-101

Department of Pathology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.

To characterize clinicopathological characteristics of the non-neoplastic colorectal polyps for accurate diagnosis. 1 190 cases were collected from the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 and their clinicopathological characteristics were reviewed. There were 746 males and 444 females patients with male/female ratio of 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.004DOI Listing
February 2019

Endoscopic Features of Sessile Serrated Adenoma/Polyps under Narrow Band Imaging: A Retrospective study.

J Dig Dis 2019 Jan 28. Epub 2019 Jan 28.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Objective: Sessile serrated adenoma/polyps (SSA/Ps) are recognized as precancerous lesions in the colon and resemble hyperplastic polyps (HPs). Definite endoscopic features under narrow band imaging (NBI) with or without magnification may help differentiate between these two lesions. Our study was designed to identify specific endoscopic features of SSA/Ps by NBI. Read More

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http://dx.doi.org/10.1111/1751-2980.12706DOI Listing
January 2019
2 Reads

Interobserver Variation of Colonic Polyp Measurement at Computed Tomography Colonography.

Can Assoc Radiol J 2019 Feb;70(1):44-51

Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia.

Background: The concept of "advanced polyps" is well accepted and is defined as polyps ≥10 mm and/or those having a villous component and/or demonstrating areas of dysplasia. Of these parameters, computed tomography colonography (CTC) can only document size. The accepted management of CTC-detected "advanced polyps" is to recommend excision if feasible, whereas the management of "intermediate" (6-9 mm) polyps is more controversial, and interval surveillance may be acceptable. Read More

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http://dx.doi.org/10.1016/j.carj.2018.09.007DOI Listing
February 2019
1 Read
0.584 Impact Factor

Endoscopic resection techniques for colorectal neoplasia: Current developments.

World J Gastroenterol 2019 Jan;25(3):300-307

Institute for Pathology, Bonn Duisdorf, Bonn 53123, Germany.

Endoscopic polypectomy and endoscopic mucosal resection (EMR) are the established treatment standards for colorectal polyps. Current research aims at the reduction of both complication and recurrence rates as well as on shortening procedure times. Cold snare resection is the emerging standard for the treatment of smaller (< 5mm) polyps and is possibly also suitable for the removal of non-cancerous polyps up to 9 mm. Read More

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http://dx.doi.org/10.3748/wjg.v25.i3.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343101PMC
January 2019

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy.

GE Port J Gastroenterol 2018 Dec 27;26(1):40-53. Epub 2018 Mar 27.

Department of Gastroenterology, Instituto Português de Oncologia do Porto, Porto, Portugal.

Narrow-band imaging is an advanced imaging system that applies optic digital methods to enhance endoscopic images and improves visualization of the mucosal surface architecture and microvascular pattern. Narrow-band imaging use has been suggested to be an important adjunctive tool to white-light endoscopy to improve the detection of lesions in the digestive tract. Importantly, it also allows the distinction between benign and malignant lesions, targeting biopsies, prediction of the risk of invasive cancer, delimitation of resection margins, and identification of residual neoplasia in a scar. Read More

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https://www.karger.com/Article/FullText/487470
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http://dx.doi.org/10.1159/000487470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341367PMC
December 2018
7 Reads

Plasminogen activator inhibitor-1 is associated with the metabolism and development of advanced colonic polyps.

Transl Res 2018 10 6;200:43-53. Epub 2018 Jun 6.

Division of Gastroenterology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

Implications of plasminogen activator inhibitor-1 (PAI-1) in colonic polyps remain elusive. A prospective study was conducted with 188 consecutive subjects who underwent colonoscopy at a tertiary referral center. Biochemical parameters, serum PAI-1 levels, PAI-1 single-nucleotide polymorphisms (rs-1799889), and colonic polyp profiles were analyzed at baseline and 24 and 48 weeks postpolypectomy. Read More

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http://dx.doi.org/10.1016/j.trsl.2018.05.010DOI Listing
October 2018
1 Read

An uncommon cause of acute abdomen in an acromegalic patient: colonic volvulus.

Ann Ital Chir 2018 ;89:572-576

Acromegaly is a chronic endocrine disease, typically caused by a pituitary adenoma leading to increased circulating GH levels and increased IGF-I secretion by peripheral tissues. Gastrointestinal diseases related acromegaly such as colon cancers, adenomatous polyps, and dolichocolon are much less known. We aimed to present a case of complete colonic volvulus in a patient with acromegaly. Read More

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January 2018
3 Reads

A rare cause of obstructive defecation in a 29-year-old woman: Ileo-colo-colonic intussusception treated by subtotal colectomy with posterior rectopexy.

Turk J Surg 2018 Dec 1;34(4):334-336. Epub 2018 Dec 1.

Department of General Surgery, Bezmialem Vakif University School of Medicine, İstanbul, Turkey.

Adult intussusception is a rare clinical condition. In majority of adult cases, there is an underlying cause such as polyps or colon cancers. In the present study, a 29-year-old woman with intermittent and colicky abdominal pain, constipation, and painful defecation, accompanied with distention and sense of rectal fullness, was evaluated with computed tomography. Read More

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http://dx.doi.org/10.5152/turkjsurg.2017.3406DOI Listing
December 2018
1 Read

Capsule endoscopy for small-intestinal disorders: Current status.

Dig Endosc 2019 Jan 17. Epub 2019 Jan 17.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Small-bowel capsule endoscopy (SBCE) is used widely because of its non-invasive and patient-friendly nature. SBCE can visualize entire small-intestinal mucosa and facilitate detection of small-intestinal abnormalities. In this review article, we focus on the current status of SBCE. Read More

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http://doi.wiley.com/10.1111/den.13346
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http://dx.doi.org/10.1111/den.13346DOI Listing
January 2019
8 Reads

A case report of hamartomatous polyposis in an individual with Neurofibromatosis type 1.

Clin Case Rep 2019 Jan 11;7(1):202-205. Epub 2018 Dec 11.

Baylor College of Medicine Houston Texas.

Even in well-described genetic syndromes, such as neurofibromatosis type 1, expansion of the phenotype should be considered as a possible explanation for atypical presentations. However, it is critical to complete the evaluation for a potential dual diagnosis, as there could be significant prognostic and management implications. Read More

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http://dx.doi.org/10.1002/ccr3.1908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333055PMC
January 2019
1 Read

Annexin A10 and HES-1 Immunohistochemistry in Right-sided Traditional Serrated Adenomas Suggests an Origin From Sessile Serrated Adenoma.

Appl Immunohistochem Mol Morphol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathology and Laboratory Medicine, University of Calgary, Cumming School of Medicine and Calgary Laboratory Services, Calgary, AB, Canada.

There is increasing body of evidence to suggest that some colonic serrated polyps do not fit morphologically with any of the proposed categories for serrated polyps recommended by the World Health Organization. Most of these polyps have morphologic features of traditional serrated adenoma (TSA) admixed with areas resembling sessile serrated adenoma (SSA) or hyperplastic polyp (HP). Based on these findings it has been suggested that at least some TSAs may arise in association with precursor HP or SSA lesions, particularly those that develop in right colon. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000740DOI Listing
January 2019

Should we worry about incidental gastrointestinal tract involvement in positron emission tomography/computed tomography as gastroenterologist?

Acta Gastroenterol Belg 2018 Oct-Dec;81(4):471-475

Istanbul University, Istanbul Medical Faculty, Department of Gastroenterology.

Background And Aim: Positron emission tomography/computed tomography(PET/CT) scans detects benign clinical conditions in addition to malignancy, and this leads to additional investigation and expenditure. The purpose of our study was to assess the endoscopic and histopathologic results of incidental 18F-FDG uptake in the GI tract.

Patients And Method: We enrolled 110 patients who underwent gastroscopy/colonoscopy for incidental GI tract involvement in PET/CT. Read More

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January 2019
4 Reads

Is Ablation of the Endoscopic Mucosal Resection Margin the New Standard for Colorectal Polyps?

Gastroenterology 2019 02 11;156(3):546-548. Epub 2019 Jan 11.

Dartmouth Geisel School of Medicine, Hanover, New Hampshire and Section of Gastroenterology and Hepatology, VA White River Junction, Vermont. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193003
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http://dx.doi.org/10.1053/j.gastro.2019.01.014DOI Listing
February 2019
5 Reads

Colon capsule endoscopy for colonic surveillance.

Colorectal Dis 2019 Jan 13. Epub 2019 Jan 13.

Department of Surgery, Odense University Hospital, Odense, Denmark.

Aim: Resources used in surveillance colonoscopies are taking up an increasing proportion of colonoscopy capacity. Colon capsule endoscopy (CCE) is a promising technique for noninvasive investigation of the colon. We aimed to investigate CCE as a possible filter in colonic surveillance with the primary outcome of reducing the number of colonoscopies. Read More

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http://doi.wiley.com/10.1111/codi.14557
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http://dx.doi.org/10.1111/codi.14557DOI Listing
January 2019
8 Reads

Gut bacteria are required for the benefits of black raspberries in mice.

J Berry Res 2018 20;8(4):239-249. Epub 2018 Dec 20.

Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.

Background: The gut microbiota plays a pivotal role in the development of inflammatory bowel disease and colorectal cancer.

Objective: To determine whether the gut microbiota is required for the chemoprotective effects of black raspberries (BRBs) in mice.

Methods: mice were given (a) a control diet for 8 weeks, or (b) the control diet for 4 weeks and then a 5% BRB diet for additional 4 weeks, or (c) the control diet and antibiotics for 4 weeks followed by the 5% BRB diet and antibiotics for the next 4 weeks. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/JBR-180337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326590PMC
December 2018
7 Reads

Underlying Colorectal Cancer Was Rarely Detected After an Episode of Acute Diverticulitis: a Retrospective Analysis of 225 Patients.

J Gastrointest Cancer 2019 Jan 10. Epub 2019 Jan 10.

Gastroenterology and endoscopy united, The Nazareth Hospital, EMMS, Nazareth, Israel.

Purpose: The aim of the present study was to determine the prevalence of underlying colorectal carcinoma (CRC) in a cohort of patients who experienced an episode of acute diverticulitis and to assess clinical and laboratory parameters that suggest CRC diagnosis.

Methods: We performed a single center retrospective study in EMMS Nazareth Hospital from April 2014 to April 2018. All Patients who experienced an episode of acute diverticulitis and underwent a colonoscopy up to 6-month period were included in the study. Read More

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http://link.springer.com/10.1007/s12029-019-00202-3
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http://dx.doi.org/10.1007/s12029-019-00202-3DOI Listing
January 2019
8 Reads

Management of local recurrence after endoscopic resection of neoplastic colonic polyps.

World J Gastrointest Endosc 2018 Dec;10(12):378-382

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka 541-8567, Chuo-ku, Japan.

A proportion of neoplastic polyps are incompletely resected, resulting in local recurrence, especially after resection of large polyps or piecemeal resection. Local recurrences that develop after endoscopic resection of intramucosal neoplasms that lacked risk factors for lymph node metastasis or positive vertical margins are usually treated endoscopically. Endoscopic submucosal dissection (ESD) is indicated for local residual or recurrent early carcinomas after endoscopic resection. Read More

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http://dx.doi.org/10.4253/wjge.v10.i12.378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323499PMC
December 2018

Incidentally Detected Amyloid Light-Chain Amyloidosis Caused by Monoclonal Gammopathy of Undetermined Significance: Possible Time-Dependent Change in Colonic Findings.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):737-746. Epub 2018 Dec 6.

Division of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Hirakata, Hirakata, Japan.

Amyloid light-chain (AL) amyloidosis is associated with plasma cell disorder and monoclonal light chains. This type of amyloidosis is the prominent type involving the gastrointestinal tract. Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell disorder and a known precursor of more serious diseases. Read More

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http://dx.doi.org/10.1159/000494919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323391PMC
December 2018
1 Read

Novel Vaccine Targeting Colonic Adenoma: a Pre-clinical Model.

J Gastrointest Surg 2019 Mar 8;23(3):626-633. Epub 2019 Jan 8.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.

Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the USA. Over 80% of CRC develop from adenomatous polyps. Hence, early treatment and prevention of adenomas would lead to a significant decrease of disease burden for CRC. Read More

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http://link.springer.com/10.1007/s11605-018-4060-y
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http://dx.doi.org/10.1007/s11605-018-4060-yDOI Listing
March 2019
16 Reads

Endoscopic surveillance after colonic polyps and colorrectal cancer resection. 2018 update.

Gastroenterol Hepatol 2019 Mar 6;42(3):188-201. Epub 2019 Jan 6.

Servicio de Gastroenterología, Hospital Universitario de Canarias, San Cristóbal de La Laguna, Santa Cruz de Tenerife, España.

There is limited scientific evidence available to stratify the risk of developing metachronous colorectal cancer after resection of colonic polyps and to determine surveillance intervals and is mostly based on observational studies. However, while awaiting further evidence, the criteria of endoscopic follow-up needs to be unified in our setting. Therefore, the Spanish Association of Gastroenterology, the Spanish Society of Family and Community Medicine, the Spanish Society of Digestive Endoscopy, and the Colorectal Cancer Screening Group of the Spanish Society of Epidemiology, have written this consensus document, which is included in chapter 10 of the "Clinical Practice Guideline for Diagnosis and Prevention of Colorectal Cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02105705183031
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http://dx.doi.org/10.1016/j.gastrohep.2018.11.001DOI Listing
March 2019
9 Reads

Quality measures improving endoscopic screening of colorectal cancer: a review of the literature.

Expert Rev Anticancer Ther 2019 Mar 13;19(3):223-235. Epub 2019 Jan 13.

a Section of Gastroenterology , S.Elia - Raimondi Hospital , Caltanissetta , Italy.

Introduction: Colorectal cancer (CRC) is a major health-care problem all over the world and CRC screening is effective in reducing mortality and increasing the 5-year survival. Colonoscopy has a central role in CRC screening. It can be performed as a primary test, as a recall policy after a positive result of another screening test, and for surveillance. Read More

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http://dx.doi.org/10.1080/14737140.2019.1565999DOI Listing
March 2019
11 Reads

Use of image-enhanced endoscopy in the characterization of colorectal polyps: Still some ways to go.

Saudi J Gastroenterol 2018 Dec 27. Epub 2018 Dec 27.

Gastroenterology Divisions, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Gastroenterology Division, McGill University Health Center, Montreal General Hospital, McGill University, Montreal, Canada.

Background/aim: Instrument-based image-enhanced endoscopy (IEE) is of benefit in detecting and characterizing lesions during colonoscopy. We aimed to study the ability of community-based gastroenterologists to differentiate between neoplastic and non-neoplastic lesions using IEE modalities and to identify predictors of correct classification and the confidence of the optical diagnosis made.

Materials And Methods: : An electronic survey was sent to practicing gastroenterologists using electronic tablets during a gastroenterology meeting. Read More

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http://dx.doi.org/10.4103/sjg.SJG_417_18DOI Listing
December 2018
8 Reads
1.221 Impact Factor

Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients.

BMJ Open Gastroenterol 2018 28;5(1):e000253. Epub 2018 Nov 28.

Department of Gastroenterology, Saint George Hospital University Medical Center, Beirut, Lebanon.

Background And Aim: Colorectal cancer (CRC) has an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of adenoma detection in an outpatient clinic in Lebanon.

Patients And Methods: 918 patients underwent colonoscopy over a period of 24 months by a qualified physician. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280908PMC
November 2018
1 Read

Same-day colon capsule endoscopy is a viable means to assess unexplored colonic segments after incomplete colonoscopy in selected patients.

United European Gastroenterol J 2018 Dec 15;6(10):1556-1562. Epub 2018 Sep 15.

Trinity Academic Gastroenterology Group, Trinity College Dublin & Tallaght University Hospital, Dublin, Ireland.

Background: Same-day colon capsule endoscopy (CCE) immediately following incomplete optical colonoscopy (OC) would have a number of advantages for patients, while also presenting unique procedural challenges including the effect of sedation on capsule propulsion and patient tolerance of protracted preparation and fasting.

Aim: The aim of this article is to prospectively assess the efficacy of same-day CCE after incomplete OC in an unselected patient cohort.

Methods: This was an observational, prospective, single-centre study of CCE post-incomplete colonoscopies. Read More

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http://dx.doi.org/10.1177/2050640618800629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297922PMC
December 2018
3 Reads

Diagnostic accuracy of i-scan image enhancement for real-time endoscopic diagnosis of small colorectal polyps: a meta-analysis.

Therap Adv Gastroenterol 2018 6;11:1756284818814948. Epub 2018 Dec 6.

Imperial College London Department of Surgery and Cancer, London, UK.

Objective: i-Scan is a digital image enhancement technology, reported to improve diagnostic performance during endoscopy. Previous studies have investigated the accuracy of i-scan for distinguishing between neoplastic and non-neoplastic colonic polyps and suggested diagnostic accuracy close to that required for use in routine clinical practice. The aim of this study was to perform a meta-analysis of the available literature investigating diagnostic accuracy for i-scan optical diagnosis when made in real time for colorectal polyps <10 mm in size. Read More

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http://dx.doi.org/10.1177/1756284818814948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295743PMC
December 2018
8 Reads

Two Czech patients with familial adenomatous polyposis presenting mosaicism in APC gene.

Neoplasma 2018 Dec 12. Epub 2018 Dec 12.

Molecular Diagnostics, Institute of Biology and Medical Genetics of the 1st Medical Faculty, Charles University, Prague, Czech Republic.

During standard molecular diagnostic procedure, two Czech families with APC (Adenomatous polyposis coli gene) mosaicism have been detected. A woman with attenuated familial adenomatous polyposis (AFAP, OMIM #175100) was recently inspected by next generation sequencing. Standard bioinformatics pipeline, restricted to variants with at least 20% of reads (for germline variants) would miss mutation p. Read More

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http://dx.doi.org/10.4149/neo_2018_180731N559DOI Listing
December 2018
1 Read

Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar: A single-blind observational study.

World J Gastroenterol 2018 Dec;24(45):5179-5188

Gastroenterology Department, Hospital del Mar, Barcelona 08003, Spain.

Aim: To assess the incremental benefit of narrow band imaging (NBI) and white light endoscopy (WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic piecemeal mucosal resection (EPMR).

Methods: We conducted an observational study in an academic center to assess the incremental benefit of NBI and WLE randomly applied 1:1 (NBI-WLE or WLE-NBI) in the follow-up of a post-EPMR scar by the same endoscopist.

Results: A total of 112 EPMR scars were included. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5179.htm
Publisher Site
http://dx.doi.org/10.3748/wjg.v24.i45.5179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288651PMC
December 2018
8 Reads

Effect of time of day and specialty on polyp detection rates in Australia.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

Background And Aim: Adenoma detection rate (ADR) is an important quality metric in colonoscopy. However, there is conflicting evidence around factors that influence ADR. This study aims to investigate the effect of time of day and endoscopist background on ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) for screening colonoscopies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14566
Publisher Site
http://dx.doi.org/10.1111/jgh.14566DOI Listing
December 2018
21 Reads

Evaluation of endoscopic mucosal resection and endoscopic submucosal dissection in submucosal lesions of the colon and rectum.

Wideochir Inne Tech Maloinwazyjne 2018 Dec 8;13(4):448-453. Epub 2018 Oct 8.

Department of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.

Introduction: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are commonly used for the minimally invasive treatment of submucosal lesions of the gastrointestinal tract.

Aim: To evaluate the safety, efficacy, outcome and recurrence rate of EMR and ESD for mucosal and submucosal lesions in the colon and rectum.

Material And Methods: Records of 26 patients who underwent ESD and EMR for mucosal and submucosal lesions in the colon and rectum between January 2013 and March 2018 in our endoscopy unit were retrospectively reviewed. Read More

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http://dx.doi.org/10.5114/wiitm.2018.78829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280075PMC
December 2018
3 Reads

Hyperplastic polyps and nonadvanced adenomas, but not advanced polypoid lesions, are detected more frequently in the presence of colonic diverticula during screening colonoscopies.

Z Gastroenterol 2018 Dec 10;56(12):1475-1480. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, University Hospital Cologne, Germany.

Hintergrund:  Die bisher veröffentlichte Studienlage zur Assoziation von Kolondivertikeln und kolorektalen Polypen einschließlich des kolorektalen Karzinoms (KRK) ist konträr. Ziel der Studie war es, die Assoziation für sämtliche relevanten histologischen Polypensubtypen, d. h. Read More

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http://dx.doi.org/10.1055/a-0755-2448DOI Listing
December 2018
2 Reads