14,755 results match your criteria Colonic Polyps


Quality of same-day CT colonography following incomplete optical colonoscopy.

Eur Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

Objectives: Same-day CT colonography (CTC) following incomplete optical colonoscopy allows patients to avoid both a delayed diagnosis and the need for repeat bowel preparation. The aim of our study is to establish the diagnostic quality of same-day CT colonography following an incomplete optical colonoscopy.

Methods: We performed a retrospective review of patients undergoing same-day CT colonography following an incomplete colonoscopy at our center between July 2015 and December 2017 (N = 245). Read More

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http://dx.doi.org/10.1007/s00330-020-06979-3DOI Listing

Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader.

Am J Case Rep 2020 Jun 29;21:e923242. Epub 2020 Jun 29.

Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA.

BACKGROUND Inflammatory pseudopolyps (IPPs) are a common manifestation in inflammatory bowel disease (IBD) with more cases reported with ulcerative colitis than Crohn's disease. IPPs can grow to form large polyps which are called giant inflammatory polyps (GIPs). These polyps may cause an obstruction and form a mass-like lesion and surgical resection may be warranted. Read More

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http://dx.doi.org/10.12659/AJCR.923242DOI Listing

Audit of the impact of the York faecal calprotectin care pathway on colonoscopy activity.

Frontline Gastroenterol 2020 24;11(4):285-289. Epub 2019 Oct 24.

Biochemistry, York Teaching Hospital NHS Foundation Trust, York, UK.

Background: The York faecal calprotectin care pathway (YFCCP) was developed to optimise effective primary care differentiation between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). We undertook an audit of colonoscopy activity at York Teaching Hospitals after the introduction of the YFCCP, to assess its impact.

Methods: Faecal calprotectin (FC) results were reconciled with colonoscopy activity in patients 18-60 years after the implementation of the YFCCP. Read More

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http://dx.doi.org/10.1136/flgastro-2019-101315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307046PMC
October 2019

Activities of matrix metalloproteinase-2, matrix metalloproteinase-9, and serine proteases in samples of the colorectal mucosa of Miniature Dachshunds with inflammatory colorectal polyps.

Am J Vet Res 2020 Jul;81(7):572-580

Objective: To investigate the activities of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) and serine proteases in the colorectal mucosa of Miniature Dachshunds (MDs) with inflammatory colorectal polyps (ICRPs).

Animals: 15 MDs with ICRPs and 5 dogs with non-ICRP-related large bowel diarrhea (controls).

Procedures: Zymographic methods were used to evaluate the activities of MMP-2, MMP-9, latent forms of MMP-2 and MMP-9 (pro-MMP-2 and pro-MMP-9), and serine proteases in inflamed and noninflamed tissue samples from MDs with ICRPs and in noninflamed tissue samples from control dogs. Read More

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http://dx.doi.org/10.2460/ajvr.81.7.572DOI Listing

Different factors are associated with conventional adenoma and serrated colorectal neoplasia.

Nagoya J Med Sci 2020 May;82(2):335-343

Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.

Current data shows there are differences in factors associated with colorectal neoplasia based on geographical location and cultural settings. There are no studies focusing on the association between environmental factors and colorectal polyps in Australia. The aim of this study was to prospectively evaluate the association of various factors with different colorectal neoplasia histology. Read More

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http://dx.doi.org/10.18999/nagjms.82.2.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276409PMC

Evolving pathologic concepts of serrated lesions of the colorectum.

J Pathol Transl Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Here, we provide an up-to-date review of the histopathology and molecular pathology of serrated colorectal lesions. First, we introduce the updated contents of the 2019 World Health Organization classification for serrated lesions. The sessile serrated lesion (SSL) is a new diagnostic terminology that replaces sessile serrated adenoma and sessile serrated polyp. Read More

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http://dx.doi.org/10.4132/jptm.2020.04.15DOI Listing

High risk of colorectal polyps in male with non-alcoholic fatty liver disease: a systematic review and meta-analysis.

J Gastroenterol Hepatol 2020 Jun 24. Epub 2020 Jun 24.

Department of Gastroenterology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.

Background And Aim: This meta-analysis aims to explore the risk of colorectal polyps among non-alcoholic fatty liver disease (NAFLD) patients.

Methods: We searched Pubmed, EMBASE and Cochrane library databases using predefined search term to identify eligible studies (published up to November 07, 2019). Data from selected studies were extracted by using a standardized information collection form and meta-analyses were performed using random-effects model. Read More

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http://dx.doi.org/10.1111/jgh.15158DOI Listing

Efficacy of cyanoacrylate in the prevention of delayed bleeding after endoscopic mucosal resection of large colorectal polyps: a pilot study.

Int J Colorectal Dis 2020 Jun 23. Epub 2020 Jun 23.

Department of Emergency and Organ transplantation, Surgical Unit "M.Rubino", Azienda Ospedaliero Universitaria Policlinico, Bari, Italy.

Background: Postoperative bleeding is a common complication after endoscopic polypectomy, particularly after endoscopic mucosal resection (EMR) of large non-pedunculated polyps, despite prophylactic clipping can reduce its occurrence. Cyanoacrylate glue has recently been proposed as a useful tool in reducing bleeding in surgery because of its adhesive and haemostatic properties. The aim of this study is to evaluate the usefulness of endoscopic application of a modified cyanoacrylate glue in the prevention of early or delayed post EMR bleeding. Read More

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http://dx.doi.org/10.1007/s00384-020-03678-9DOI Listing

Colon Capsule Endoscopy: Indications, Findings, and Complications - Data from a Prospective German Colon Capsule Registry Trial (DEKOR).

Clin Endosc 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt am Main, Germany.

Background/aims: Reliable and especially widely accepted preventive measures are crucial to further reduce the incidence of colorectal cancer (CRC). Colon capsule endoscopy (CCE) might increase the screening numbers among patients unable or unwilling to undergo conventional colonoscopy. This registry trial aimed to document and determine the CCE indications, findings, complications, and adverse events in outpatient practices and clinics throughout Germany. Read More

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http://dx.doi.org/10.5946/ce.2020.049DOI Listing

Endoscopic Findings in Patients Under the Age of 40 Years with Hematochezia in Singapore.

Clin Endosc 2020 Jun 18. Epub 2020 Jun 18.

Department of Colorectal Surgery, Singapore General Hospital, Singapore.

Background/aims: Sigmoidoscopy is performed in most medical centers to evaluate the distal colons of young adults presenting with hematochezia who are at risk of developing proximal lesions. Colonoscopies offer more complete evaluations but are associated with a higher incidence of complications and possible low yield.

Methods: An analysis was conducted on colonoscopies performed in our center on patients 40 years of age or younger. Read More

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http://dx.doi.org/10.5946/ce.2019.029DOI Listing

EMR/ESD: Techniques, Complications, and Evidence.

Curr Gastroenterol Rep 2020 Jun 15;22(8):39. Epub 2020 Jun 15.

Baylor St Luke's Medical Center, Houston, TX, USA.

Purpose Of Review: To discuss endoscopic resection techniques of early gastrointestinal malignancy. The review will focus on the indications and outcomes of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD).

Recent Findings: EMR is indicated for upper GI lesions less than 20 mm provided they can be easily lifted and have a low risk of submucosal invasion (SMI). Read More

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http://dx.doi.org/10.1007/s11894-020-00777-zDOI Listing

Presentation and Follow-up of Familial Adenomatous Polyposis: Differences Between APC and MUTYH Mutations.

Cir Esp 2020 Jun 3. Epub 2020 Jun 3.

División de Cirugía Colorrectal, Departamento de Cirugía General, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.

Background: Familial adenomatous polyposis is described as one of the common two types of genetic disorders: APC and MUTYH gene associated polyposis syndrome and the clinical differences between the two can sometimes be unclear.

Materials And Methods: A retrospective analysis and comparison was made of clinical, surgical, and histological criteria, mutation types and the long-term results of patients who underwent genetic analysis which resulted in the diagnosis of Familial Adenomatous Polyposis between 1984 and 2018.

Results: Of the total 71 patients included in the study, 14 were identified with the MUTYH gene, and 57 with the APC mutation. Read More

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http://dx.doi.org/10.1016/j.ciresp.2020.04.033DOI Listing

Segmental colectomy for ulcerative colitis: is there a place in selected patients without active colitis ? An international multicentric retrospective study in 72 patients.

J Crohns Colitis 2020 Jun 4. Epub 2020 Jun 4.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy and Université de Paris, France.

Background And Aims: The aim of this study was to report a multicentric experience of segmental colectomy (SC) in ulcerative colitis (UC) patients without active colitis in order to assess if SC can represent or not an alternative to ileal pouch-anal anastomosis (IPAA).

Methods: All UC patients undergoing SC were included. Postoperative complications according to Clavien-Dindo's classification, long- term results and risk factors for postoperative colitis and reoperation for colitis on the remnant colon were assessed. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa107DOI Listing

Stool-Based Tests for Colorectal Cancer Screening: Performance Benchmarks Lead to High Expected Efficacy.

Curr Gastroenterol Rep 2020 Jun 3;22(7):32. Epub 2020 Jun 3.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Purpose Of Review: Participation goals for colorectal cancer (CRC) screening in the USA have not been met. Non-invasive screening strategies may improve CRC screening participation. We highlight recent literature on stool-based screening performance and expectations for emerging non-invasive screening tests. Read More

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http://dx.doi.org/10.1007/s11894-020-00770-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271040PMC

Impact of submucosal saline solution injection for cold snare polypectomy of small colorectal polyps: a randomized controlled study.

Gastrointest Endosc 2020 May 31. Epub 2020 May 31.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, Okayama, Japan.

Background And Aims: Cold snare polypectomy (CSP) of small colorectal polyps is widely used. However, the technique is still troubled with insufficient resection depth, which may prevent precise pathological evaluation. In this study, we investigated whether submucosal injection of saline solution helps to achieve deeper resection in CSP. Read More

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http://dx.doi.org/10.1016/j.gie.2020.05.039DOI Listing

Risk factors for endoscopic severity of diverticular disease of the colon and its outcome: a real-life case-control study.

Eur J Gastroenterol Hepatol 2020 May 29. Epub 2020 May 29.

Department of Medicine and Surgery, Gastroenterology Unit, University of Parma, Parma.

Background: Diverticular disease is an increasing global problem.

Aims: To assess the factors associated with the severity of diverticular disease and its outcome, analyzing a real-life population.

Methods: A cohort of patients, submitted to colonoscopy from 1 January 2012 to 30 April 2018 was revised. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001787DOI Listing

Role of Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.

Int J Mol Sci 2020 May 28;21(11). Epub 2020 May 28.

Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Sessile serrated adenoma/polyp with dysplasia (SSA/P-D) is an SSA/P with cellular dysplasia and has a higher risk of progressing to colon carcinogenesis. Previously, we reported that tight junction impairment by enterotoxin (CPE) leads to activation of the transcriptional co-activator yes-associated protein (YAP) in oral squamous cell carcinoma. Here, we investigated whether CPE activates YAP to promote the malignant progression of SSA/P. Read More

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http://dx.doi.org/10.3390/ijms21113840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313056PMC

Optical imaging technology in colonoscopy: Is there a role for photometric stereo?

World J Gastrointest Endosc 2020 May;12(5):138-148

Centre for Machine Vision, University of the West of England, Bristol BS16 1QY, United Kingdom.

Colonoscopy screening for the detection and removal of colonic adenomas is central to efforts to reduce the morbidity and mortality of colorectal cancer. However, up to a third of adenomas may be missed at colonoscopy, and the majority of post-colonoscopy colorectal cancers are thought to arise from these. Adenomas have three-dimensional surface topographic features that differentiate them from adjacent normal mucosa. Read More

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http://dx.doi.org/10.4253/wjge.v12.i5.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243575PMC

Cecal amebiasis mimicking inflammatory bowel disease.

J Int Med Res 2020 May;48(5):300060520922379

Western Medicine Division, Lam Wah Ee Hospital, Penang, Malaysia.

Amebiasis is a frequently occurring parasitic infection in South East Asia. We present a case of a 54-year-old man with right lower quadrant abdominal pain that persisted for longer than 1 year. He had been diagnosed with inflammatory bowel disease in Indonesia. Read More

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http://dx.doi.org/10.1177/0300060520922379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263159PMC

[Endoscopic features and clinical correlation analysis of 24 patients with Cronkhite-Canada syndrome].

Zhonghua Yi Xue Za Zhi 2020 May;100(20):1562-1566

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To clarify the endoscopic changes prior to corticosteroid therapy in Cronkhite-Canada syndrome (CCS) patients and to explore the correlation between endoscopic features and clinical characteristics. A total of 24 CCS patients who were hospitalized in Peking Union Medical College Hospital from January 1999 to June 2019 and underwent gastroscopy and colonoscopy before corticosteroid therapy were retrospectively enrolled. The endoscopic images were re-interpreted. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191125-02556DOI Listing

MANAGEMENT OF PERI-APPENDICEAL ORIFICE POLYPS.

Clin Gastroenterol Hepatol 2020 May 20. Epub 2020 May 20.

The Centre for Therapeutic Endoscopy and Endoscopic Oncology, St. Michael's Hospital, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2020.05.025DOI Listing

Colorectal Cancer Screening for the Serrated Pathway.

Gastrointest Endosc Clin N Am 2020 Jul 8;30(3):457-478. Epub 2020 Apr 8.

Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Serrated polyps are classified into hyperplastic polyps, sessile serrated adenomas/polyps, and traditional serrated adenomas. Although all serrated polyps share characteristic colonic crypts serrations, distinguishing hyperplastic polyps from sessile serrated adenomas/polyps is challenging. Traditional serrated adenomas are cytologically dysplastic lesions; sessile serrated adenomas/polyps develop cytologic dysplasia as they progress to colorectal cancer. Read More

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http://dx.doi.org/10.1016/j.giec.2020.02.007DOI Listing

AI-doscopist: a real-time deep-learning-based algorithm for localising polyps in colonoscopy videos with edge computing devices.

NPJ Digit Med 2020 18;3:73. Epub 2020 May 18.

2Division of Vascular and General Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

We have designed a deep-learning model, an "Artificial Intelligent Endoscopist (a.k.a. Read More

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http://dx.doi.org/10.1038/s41746-020-0281-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235017PMC

Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective study.

Ital J Pediatr 2020 May 20;46(1):66. Epub 2020 May 20.

Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.

Background: Colorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to predict polyps in children with isolated and sporadic rectal bleeding may play a key role in the selection of patients needing colonoscopy. Read More

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http://dx.doi.org/10.1186/s13052-020-00828-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238517PMC

Curriculum review: serrated lesions of the colorectum.

Frontline Gastroenterol 2020 5;11(3):243-248. Epub 2019 Jun 5.

Wolfson Unit for Endoscopy, St Mark's Hospital, London, UK.

Colorectal cancer (CRC) is the second leading cause of death from cancer in the UK. Sporadic CRC evolves by the cumulative effect of genetic and epigenetic alterations. Typically, over the course of several years, this leads to the transformation of normal colonic epithelium to benign adenomatous polyp, low-grade to high-grade dysplasia and finally cancer-the adenoma-carcinoma sequence. Read More

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http://dx.doi.org/10.1136/flgastro-2018-101153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223468PMC

Is surveillance colonoscopy necessary for all patients with bowel polyps?

BMJ 2020 05 15;369:m1706. Epub 2020 May 15.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK

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http://dx.doi.org/10.1136/bmj.m1706DOI Listing

Impact of EMR Automated Results Routing Tool Implementation on Notification of Inpatient Endoscopy Biopsy Results.

Jt Comm J Qual Patient Saf 2020 Jun 12;46(6):321-325. Epub 2020 Mar 12.

Background: Mucosal biopsies are often obtained during inpatient endoscopies to aid diagnosis. Up to 75% of patients are reported to have pending test results at discharge. Incomplete result communication to patients can lead to patient anxiety and poor outcomes. Read More

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http://dx.doi.org/10.1016/j.jcjq.2020.03.004DOI Listing

Plasma adiponectin, visfatin, leptin, and resistin levels and the onset of colonic polyps in patients with prediabetes.

BMC Endocr Disord 2020 May 11;20(1):63. Epub 2020 May 11.

Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, 230032, Anhui Province, China.

Background: Prediabetes is associated with a high risk of colon cancer, and abdominal obesity, which can result in the secretion of several obesity-related adipocytokines, is an independent influencing factor for colonic polyps in prediabetes subjects. However, the correlation between adipocytokine levels and colonic polyps in prediabetes subjects is unclear. This research explores the relationship between plasma adiponectin, visfatin, leptin, and resistin levels and the development of colonic polyps in prediabetes subjects. Read More

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http://dx.doi.org/10.1186/s12902-020-0540-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216429PMC

Sigmoid Leiomyoma: An Uncommon Occurrence.

Cureus 2020 Apr 6;12(4):e7567. Epub 2020 Apr 6.

Internal Medicine/Gastroenterology, Valleywise Health, Phoenix, USA.

Leiomyomas in the colon are uncommon accounting for a few cases of gastrointestinal smooth muscle tumors. These tumors are usually benign and asymptomatic. They may present with abdominal pain, intestinal obstruction, perforation, and rarely hemorrhagic, especially when the tumor is large. Read More

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http://dx.doi.org/10.7759/cureus.7567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205365PMC

Association of lncRNA-p53 regulatory network (lincRNA-p21, lincRNA-ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors.

Oncol Lett 2020 Jun 7;19(6):3937-3949. Epub 2020 Apr 7.

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.

Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. Read More

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http://dx.doi.org/10.3892/ol.2020.11518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204634PMC
June 2020
0.987 Impact Factor

Retrograde inspection standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial.

World J Gastroenterol 2020 Apr;26(16):1962-1970

Department of Internal Medicine, Division of Gastroenterology, Klinikum Fürth, Fürth 90766, Germany.

Background: The adenoma detection rate (ADR) is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy. However, adenoma miss rates reach up to 26% and studies have shown that a second inspection of the right colon in retroflected view (RFV) can increase ADR.

Aim: To assess whether inspection of the whole colon in RFV compared to standard forward view (SFV) can increase ADR. Read More

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http://dx.doi.org/10.3748/wjg.v26.i16.1962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201142PMC

Lymphocytic colitis pattern of injury presenting as endoscopic polyps: a case series.

Hum Pathol 2020 Jul 5;101:10-17. Epub 2020 May 5.

Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, USA. Electronic address:

Lymphocytic colitis (LC) is characterized by chronic watery diarrhea and unremarkable endoscopic findings. Only one case of LC presenting as multiple colonic polyps has been reported. We report a case series of histologic LC pattern of injury (LCPI), presenting as endoscopic polyps, and compare them with typical LC cases. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.008DOI Listing

Paradoxical interaction between cancer and long-term postsepsis disorder: impairment of de novo carcinogenesis versus favoring the growth of established tumors.

J Immunother Cancer 2020 May;8(1)

Cancer Institute of Ceara, Fortaleza, Brazil.

Background: Previous data have reported that the growth of established tumors may be facilitated by postsepsis disorder through changes in the microenvironment and immune dysfunction. However, the influence of postsepsis disorder in initial carcinogenesis remains elusive.

Methods: In the present work, the effect of postsepsis on inflammation-induced early carcinogenesis was evaluated in an experimental model of colitis-associated colorectal cancer (CAC). Read More

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http://dx.doi.org/10.1136/jitc-2019-000129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223471PMC

New insights on missed colonic lesions during colonoscopy through artificial intelligence-assisted real-time detection (with video).

Gastrointest Endosc 2020 May 3. Epub 2020 May 3.

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. Electronic address:

Background And Aims: Recent meta-analysis showed that up to 26% of adenoma could be missed during colonoscopy. We investigated whether the use of artificial intelligence (AI) assisted real-time detection could provide new insights into mechanisms underlying missed lesions during colonoscopy.

Methods: A validated real-time deep learning AI model for detection of colonic polyps was first tested in the videos of tandem colonoscopy of the proximal colon for missed lesions. Read More

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http://dx.doi.org/10.1016/j.gie.2020.04.066DOI Listing

Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states.

Int J Colorectal Dis 2020 Jul 1;35(7):1351-1354. Epub 2020 May 1.

Department of Gastroenterology, University of California Irvine Medical Center, Orange, CA, USA.

Background: The association of TSAs with metachronous neoplasms is well established and suggests that TSAs would also have an association with synchronous neoplasms.

Methods: We compared odds ratios and rates of synchronous neoplasms found in colonoscopies with and without TSAs.

Results: There was a mean of 2. Read More

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http://dx.doi.org/10.1007/s00384-020-03587-xDOI Listing

The risk of residual or recurring adenoma after piecemeal endoscopic mucosal resection of large non-pedunculated colorectal polyps is predictable.

Eur J Gastroenterol Hepatol 2020 Jun;32(6):713-717

Gastroenterology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora.

Introduction/objective: Piecemeal endoscopic mucosal resection is a safe and effective procedure for the management of large non-pedunculated colorectal polyps. Its major limitation is the possibility of residual or recurrent adenoma and the consequent need for scheduled surveillance colonoscopies, with the implied burden for the patient and health systems. We aimed to evaluate if the Size/Morphology/Site/Access (SMSA) and Sydney EMR Recurrence Tool (SERT) scores are effective in predicting residual/recurrent adenoma after piecemeal endoscopic resection of large non-pedunculated colorectal polyps. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001739DOI Listing
June 2020
2.152 Impact Factor

Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin.

Clin Transl Gastroenterol 2020 Mar;11(3):e00143

Laboratorio de Investigación, Hospital General Universitario de Alicante, Instituto de Investigación sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.

Objectives: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps.

Methods: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145049PMC

The Status of Advanced Imaging Techniques for Optical Biopsy of Colonic Polyps.

Clin Transl Gastroenterol 2020 Mar;11(3):e00130

Department of Surgery and Cancer, Imperial College London, London, UK.

The progressive miniaturization of photonic components presents the opportunity to obtain unprecedented microscopic images of colonic polyps in real time during endoscopy. This information has the potential to act as "optical biopsy" to aid clinical decision-making, including the possibility of adopting new paradigms such as a "resect and discard" approach for low-risk lesions. The technologies discussed in this review include confocal laser endomicroscopy, optical coherence tomography, multiphoton microscopy, Raman spectroscopy, and hyperspectral imaging. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145035PMC

Mucosa-associated Lymphoid Tissue Lymphoma of Colon: A Case Report and Literature Review of Rare Entity.

Cureus 2020 Mar 27;12(3):e7438. Epub 2020 Mar 27.

Gastroenterology, University of California, Los Angeles/David Geffen School of Medicine, Los Angeles, USA.

Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) accounts for approximately 5% of non-Hodgkin lymphomas, and the gastrointestinal (GI) tract is the most common site of involvement. The stomach and small intestine are the most common sites of involvement in the GI tract. Colonic MALT lymphoma is a rare condition that comprises only 2. Read More

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http://dx.doi.org/10.7759/cureus.7438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186103PMC

Enhanced Patient Education for Colonic Polyp and Adenoma Detection: Meta-Analysis of Randomized Controlled Trials.

JMIR Mhealth Uhealth 2020 Jun 1;8(6):e17372. Epub 2020 Jun 1.

Chongqing University Cancer Hospital, Chongqing, China.

Background: To improve patients' comprehension of bowel preparation instructions before colonoscopy, enhanced patient education (EPE) such as cartoon pictures or other visual aids, phone calls, mobile apps, multimedia education and social media apps have been proposed. However, it is uncertain whether EPE can increase the detection rate of colonic polyps and adenomas.

Objective: This meta-analysis aimed to evaluate the efficacy of EPE in detecting colonic polyps and adenomas. Read More

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http://dx.doi.org/10.2196/17372DOI Listing

Comparative quantitative survey of patient experience in Barrett's oesophagus and other gastrointestinal disorders.

BMJ Open Gastroenterol 2020 31;7(1):e000357. Epub 2020 Mar 31.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.

Objective: To assess health-related quality of life in patients with non-dysplastic Barrett's oesophagus (NDBO) and endoscopically treated dysplastic Barrett's oesophagus (DBO).

Design: This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170407PMC

[A new one in the classification of benign colon epithelial tumors (WHO, 2019, 5th edition)].

Arkh Patol 2020 ;82(2):35-42

Lomonosov Moscow State University, Medical Research and Educational Center, 119192, Russian Federation, Moscow, Lomonosovsky Prospekt, 27-10.

The 2019 WHO Classification of Benign Colon Epithelial Neoplasms includes serrated dysplasia, adenomatous polyps, and glandular intraepithelial neoplasia. Serrated dysplasia (ICD-O 8213/0 and 8213/2) is former serrated masses. There is an expected change in its terminology: it is proposed to use the term 'sessile serrated lesion' (SSL) instead of that 'sessile serrated polyp/adenoma' that causes a lot of discussion. Read More

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http://dx.doi.org/10.17116/patol20208202135DOI Listing

Diagnostic yield of multigene panel testing in an Israeli cohort: enrichment of low-penetrance variants.

Breast Cancer Res Treat 2020 Jun 18;181(2):445-453. Epub 2020 Apr 18.

Rabin Medical Center, Recanati Genetics Institute, Beilinson Hospital, Petach Tikva, Israel.

Background: Carriers of pathogenic variants (PVs) in moderate-high-penetrance cancer susceptibility genes are offered tailored surveillance schemes for early cancer diagnosis. The clinical implications of low-penetrance variant carriers are less clear.

Methods: Clinical and demographic data were retrieved for a cohort of Israeli individuals who underwent oncogenetic testing by the 30-gene cancer panel at Color Genomics laboratory, between 04/2013 and 12/2018. Read More

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http://dx.doi.org/10.1007/s10549-020-05633-2DOI Listing

Narrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy.

BMC Gastroenterol 2020 Apr 16;20(1):111. Epub 2020 Apr 16.

Gastroenterology Department, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain.

Background: It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not completely fulfilling serrated polyposis syndrome (SPS) criteria.

Methods: We conducted a randomized, cross-over trial in consecutive patients with prior detection of at least one serrated polyp ≥10 mm or ≥ 3 serrated polyps larger than 5 mm, both proximal to the sigmoid colon. Five experienced endoscopists performed same-day tandem colonoscopies, with the order being randomized 1:1 to NBI-HD-WLE or HD-WLE-NBI. Read More

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http://dx.doi.org/10.1186/s12876-020-01257-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164214PMC

Huge bilharzial polyp mimicking colon cancer.

JGH Open 2020 Apr 12;4(2):280-283. Epub 2019 Apr 12.

Department of Pathology, Faculty of Medicine Mansoura University Mansoura Egypt.

Bilharziasis (Schistosomiasis) is the third devastating tropical disease globally and is endemic in many countries including Egypt. The pathology of chronic colonic schistosomiasis results from egg-induced immune response, granuloma formation, and associated fibrotic changes that may manifest as bloody diarrhea, cramping, and, eventually, inflammatory colonic polyposis. Huge polyps complicating schistosomiasis are not frequently reported in the literature. Read More

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http://dx.doi.org/10.1002/jgh3.12181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144792PMC

Complications of cold hot snare polypectomy of 10-20 mm polyps: A retrospective cohort study.

JGH Open 2020 Apr 18;4(2):172-177. Epub 2019 Aug 18.

Department of Gastroenterology Alfred Health Melbourne Victoria Australia.

Background And Aim: Cold snare polypectomy is safe and efficacious for removing polyps <10 mm with reduced rates of delayed postpolypectomy bleeding and postpolypectomy syndrome. This technique can also be used for sessile polyps ≥10 mm; however, further evidence is required to establish its safety. The aim of this study was to compare intraprocedure and postprocedure adverse events in patients who underwent cold (CSP) hot snare polypectomy (HSP) of 10-20 mm sessile colonic polyps. Read More

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http://dx.doi.org/10.1002/jgh3.12243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144768PMC

Clinical Correlation of miR-200c/141 Cluster DNA Methylation and miR-141 Expression with the Clinicopathological Features of Colorectal Primary Lesions/Tumors.

Rep Biochem Mol Biol 2019 Oct;8(3):208-215

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Background: Abnormal DNA methylation leading to altered transcription of certain genes occurs frequently in colorectal cancer (CRC). As with protein-coding genes, microRNAs (miRNAs) may be targeted for methylation in CRC; however, the methylation state of miRNA genes in CRC, especially in primary lesions, has not yet been completely elucidated. To understand the impact of DNA methylation on the miR-200c/141 cluster promoter, we investigated the methylation and expression of miR-141 in precancerous lesions and colorectal cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103083PMC
October 2019

Management and Outcomes of Bleeding Within 30 Days of Colonic Polypectomy in a Large, Real-life Multicenter Cohort Study.

Clin Gastroenterol Hepatol 2020 Apr 6. Epub 2020 Apr 6.

Department of Gastroenterology, Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universitat de Barcelona, Barcelona, Spain. Electronic address:

Background & Aims: Management of delayed (within 30 days) post-polypectomy bleeding (DPPB) has not been standardized. Patients often undergo colonoscopies that do not provide any benefit. We aimed to identify factors associated with therapeutic intervention and active bleeding after DPPB. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.03.068DOI Listing

Magnification endoscopy in combination with acetic acid enhancement and narrow-band imaging for the accurate diagnosis of colonic neoplasms.

Endosc Int Open 2020 Apr 23;8(4):E488-E497. Epub 2020 Mar 23.

Department of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.

 Magnification endoscopy with narrow-band imaging (NBIME) and NBIME with acetic acid enhancement (A-NBIME) enable visualization of the vascular and microstructural patterns of colorectal polyp. We compared the diagnostic accuracy and reproducibility of white light endoscopy (WLE), NBIME, and A-NBIME for predictive histologic diagnosis.  Consecutive colorectal polyps (N = 628; 38 hyperplasias, 488 adenomas, 72 M-SM1 cancers, and 30 SM2 cancers) were photographed with WLE, NBIME, and A-NBIME. Read More

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http://dx.doi.org/10.1055/a-1068-2056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089791PMC