15,262 results match your criteria Colonic Polyps

A Pilot Randomized Trial of Polypectomy Techniques for 4 to 6 mm Colonic Polyps.

J Clin Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Department of Internal Medicine/Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN.

Background And Goals: There is variation in polypectomy techniques for resection of small polyps. Aim was to compare techniques for 4 to 6 mm polyps for recurrent adenoma, efficiency, and adverse events and to establish methodological factors for definitive trial.

Materials And Methods: The study was a randomized controlled trial. Read More

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Will a flexi-sig' do? A retrospective review of colonoscopies indicated by diverticulitis alone.

Surg Endosc 2021 Jun 10. Epub 2021 Jun 10.

Dept. General Surgery, Caboolture Hospital, 97/120 McKean Street, Caboolture, QLD, 4510, Australia.

Background: The incidence of colonic diverticulitis is increasing. In Australia the majority of diverticulitis occurs in the left colon and patients typically undergo colonoscopy following an attack. At present debate exists regarding the utility of this costly procedure and a flexible sigmoidoscopy has been proposed as a cheaper, less invasive alternative. Read More

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APC germline variant analysis in the adenomatous polyposis phenotype in Japanese patients.

Int J Clin Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Background: Familial adenomatous polyposis (FAP), an autosomal dominant disorder characterized by multiple colonic polyps, is caused by a germline pathogenic variant of the APC gene. However, this variant is not detected in up to 30% of patients with the adenomatous polyposis phenotype.

Methods: We performed next-generation sequencing (NGS) to identify the causative genes in FAP patients with 10 or more polyps. Read More

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RNNSLAM: Reconstructing the 3D colon to visualize missing regions during a colonoscopy.

Med Image Anal 2021 May 19;72:102100. Epub 2021 May 19.

University of North Carolina at Chapel Hill, Chapel Hill, NC 27705, USA.

Colonoscopy is the gold standard for pre-cancerous polyps screening and treatment. The polyp detection rate is highly tied to the percentage of surveyed colonic surface. However, current colonoscopy technique cannot guarantee that all the colonic surface is well examined because of incomplete camera orientations and of occlusions. Read More

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OVOL2 attenuates the expression of MAP3K8 to suppress epithelial mesenchymal transition in colorectal cancer.

Pathol Res Pract 2021 May 25;224:153493. Epub 2021 May 25.

Laboratory of Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China; Department of Clinical Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen, China. Electronic address:

Background: Inactivation of members of the OVO-like family of C2H2 zinc-finger transcription factor 2 (OVOL2) is increased after colorectal cancer (CRC) metastasis. This study investigated the functional roles and clinical relevance of OVOL2 and its downstream factors in colorectal carcinogenesis.

Methods: Transcriptome RNA sequencing (RNA-seq) of HCT116 cells overexpressing OVOL2 and SW480 cells silencing OVOL2 were conducted. Read More

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Linked Colour imaging for the detection of polyps in patients with Lynch syndrome: a multicentre, parallel randomised controlled trial.

Gut 2021 Mar 18. Epub 2021 Mar 18.

Gastroenterology and Hepatology, Amsterdam UMC Location AMC, Amsterdam, North Holland, The Netherlands

Objective: Despite regular colonoscopy surveillance, colorectal cancers still occur in patients with Lynch syndrome. Thus, detection of all relevant precancerous lesions remains very important. The present study investigates Linked Colour imaging (LCI), an image-enhancing technique, as compared with high-definition white light endoscopy (HD-WLE) for the detection of polyps in this patient group. Read More

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[Histopathological classification of colorectal non-invasive epithelial lesions].

J Li X D Teng M D Lai

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):695-700

Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China.

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Endoscopic techniques to reduce recurrence rates after colorectal EMR: systematic review and meta-analysis.

Surg Endosc 2021 Jun 2. Epub 2021 Jun 2.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Radboud Institute for Health Sciences, 6500 HB, Nijmegen, The Netherlands.

Background: Colorectal endoscopic mucosal resection (EMR) is an effective, safe, and minimally invasive treatment for large lateral spreading and sessile polyps. The reported high recurrence rate of approximately 20% is however one of the major drawbacks. Several endoscopic interventions have been suggested to reduce recurrence rates. Read More

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Usefulness of a Colonoscopy Cap with an External Grid for the Measurement of Small-Sized Colorectal Polyps: A Prospective Randomized Trial.

J Clin Med 2021 May 27;10(11). Epub 2021 May 27.

Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju 24626, Korea.

Accurate measurement of polyp size during colonoscopy is crucial. The usefulness of cap-assisted colonoscopy and external grid application on monitor (gCAP) was evaluated for polyp size measurement in this 3-year, single-center, single-blind, randomized trial. Using the endoscopic forceps width as reference, the discrepancy percent (DP), error rate (ER), and measurement time were compared between gCAP and visual estimation (VE) after randomization. Read More

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Scoring Systems for Clinical Colon Capsule Endoscopy-All You Need to Know.

J Clin Med 2021 May 28;10(11). Epub 2021 May 28.

Gastroenterology Department, Mater Dei Hospital, MSD 2090 Msida, Malta.

In the constantly developing era of minimal diagnostic invasiveness, the role of colon capsule endoscopy in colonic examination is being increasingly recognised, especially in the context of curtailed endoscopy services due to the COVID-19 pandemic. It is a safe diagnostic tool with low adverse event rates. As with other endoscopic modalities, various colon capsule endoscopy scores allow the standardisation of reporting and reproducibility. Read More

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Inflammatory cap polyp of the sigmoid colon: a case report.

J Med Case Rep 2021 May 29;15(1):306. Epub 2021 May 29.

Division of Surgical Gastroenterology, Department of Surgery, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal.

Background: Inflammatory cap polyp is a very rare benign entity of the distal left colon, characterized by inflammatory polyp with a "cap" of fibrinopurulent exudates. They are usually multiple and commonly present with bleeding per rectum or mucoid discharge. Solitary polyp presenting with intermittent intussusceptions is rare. Read More

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First experience in clinical application of hyperspectral endoscopy for evaluation of colonic polyps.

J Biophotonics 2021 May 28:e202100078. Epub 2021 May 28.

Department of Physics, University of Cambridge, Cambridge, United Kingdom.

Early detection and resection of adenomatous polyps prevents progression to colorectal cancer (CRC), significantly improving patient outcomes. Polyps are typically identified and removed during white-light colonoscopy. Unfortunately, the rate of interval cancers that arise between CRC screening events remains high, linked to poor visualization of polyps during screening and incomplete polyp removal. Read More

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Author commentary on De-feng Li et al.


Endoscopy 2021 06 26;53(6):v28. Epub 2021 May 26.

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[Relationship between insulin resistance, serum VCAM-1, FGF19, IGF-1 and colorectal polyps].

Zhonghua Zhong Liu Za Zhi 2021 May;43(5):553-562

Department of Endoscope, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China.

To explore the relationship between insulin resistance, glucose and lipid metabolism related molecules and colorectal polyps. A total of 262 healthy people who underwent colonoscopy in Shandong cancer hospital from June 2019 to September 2020 were selected. The levels of serum vascular cell adhesion molecule-1 (VCAM-1), fibroblast growth factor 19 (FGF19), insulin like growth factor (IGF-1), fasting blood glucose and fasting blood insulin were detected by enzyme-linked immunosorbent assay (ELISA). Read More

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The inflammatory microenvironment in screen-detected premaligant adenomatous polyps: early results from the integrated technologies for improved polyp surveillance (INCISE) project.

Eur J Gastroenterol Hepatol 2021 Jul;33(7):983-989

Academic Unit of Surgery, University of Glasgow, Glasgow Royal Infirmary.

Introduction: Around 40% of patients who attend colonoscopy following a positive stool screening test have adenomatous polyps. Identifying which patients have a higher propensity for malignant transformation is currently poorly understood. The aim of the present study was to assess whether the type and intensity of inflammatory infiltrate differ between screen-detected adenomas with high-grade dysplasia (HGD) and low-grade dysplasia (LGD). Read More

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Impact of Comprehensive Optical Diagnosis Training using WASP Classification on Detection of Adenoma and Sessile Serrated lesion.

Dig Endosc 2021 May 21. Epub 2021 May 21.

Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.

Objectives: Many interventions have been attempted to improve adenoma detection rate (ADR) and sessile serrated lesion detection rate (SDR), and one of these interventions is educational training to recognize polyp characteristics. This study aimed to investigate the change in polyp detection rates of endoscopists before and after comprehensive training through the Gangnam-Real Time Optical Diagnosis (Gangnam-READI) program.

Methods: Fifteen gastroenterologist participated in a 1-year comprehensive training program that consisted of ex vivo and in vivo training that encompasses knowledge and skills in endoscopic characterization of colonic polyps using the Workgroup serrAted polypS and Polyposis (WASP) classification. Read More

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Torpedo-like lesions in the ocular fundi of Gardner syndrome: hiding in plain view.

Ophthalmic Genet 2021 May 20:1-7. Epub 2021 May 20.

Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.

The coexistence of fundus torpedoes and Gardner syndrome was initially reported in 1989 and 1992 by Gass and Roseman. Gardner syndrome is a dominantly inherited disease characterized by a multitude of potentially lethal gastrointestinal polyps. Over the ensuing quarter century, several publications demonstrated uncommon, but easily recognized, fundus lesions called Torpedo Maculopathy in apparently normal individuals. Read More

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Clinical Significance of Pathologic Abnormalities in Biopsy Samples from the Appendiceal Orifice.

Histopathology 2021 May 20. Epub 2021 May 20.

Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Aims: Appendiceal orifice mucosa often appears inflamed endoscopically, even when other colonic segments look normal. Histological findings in biopsy samples taken from endoscopically abnormal mucosa may simulate a variety of inflammatory colitides. We performed this study to evaluate the clinical implications of inflammatory changes isolated to the appendiceal orifice. Read More

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Prevalence and predictors of colon polyps in patients with skin tags: A cross sectional study.

J Cosmet Dermatol 2021 May 19. Epub 2021 May 19.

Department of Dermatology, National Research Centre, Cairo, Egypt.

Background: Acrochordons (fibroepithelial polyps, skin tags, papillomas) are common benign neoplasms of the skin.

Aim: To identify the prevalence of colonic polyps among patients presenting with skin tags and to determine a useful criteria for screening with colonoscopy.

Methods: Two hundred patients who fulfilled the selection criteria underwent physical, biochemical evaluation (fasting blood sugar (FBS), body mass index (BMI) calculation, occult blood in stool), and histopathological examination of the skin tags. Read More

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Persistent Colonic Schistosomiasis among Symptomatic Rural Inhabitants in the Egyptian Nile Delta.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021033. Epub 2021 May 1.

Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background And Aims: Human schistosomiasis is one of the most important and unfortunately neglected tropical diseases. The aim of the current study was to investigate the prevalence and characteristics of colonic schistosomiasis among symptomatic rural inhabitants of the Middle Northern region of the Egyptian Nile delta.

Patients And Methods: This study recruited 193 inhabitants of the rural community in the Egyptian Nile Delta referred for colonoscopy because of variable symptoms. Read More

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Automatic colonic polyp detection using integration of modified deep residual convolutional neural network and ensemble learning approaches.

Comput Methods Programs Biomed 2021 Jul 14;206:106114. Epub 2021 Apr 14.

Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia. Electronic address:

Background And Objective: The increased incidence of colorectal cancer (CRC) and its mortality rate have attracted interest in the use of artificial intelligence (AI) based computer-aided diagnosis (CAD) tools to detect polyps at an early stage. Although these CAD tools have thus far achieved a good accuracy level to detect polyps, they still have room to improve further (e.g. Read More

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[Features and choice of surgical strategy in patients with gastrointestinal fistulas].

Khirurgiia (Mosk) 2021 (5):58-62

Samara State Medical University, Samara, Russia.

Objective: To evaluate the features and choice of surgical strategy in patients with gastrointestinal fistula based on classification of their types.

Material And Methods: There were 398 patients with gastrointestinal fistula. Fistula type 1 was found in 126 (31. Read More

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Increased Risk of Advanced Colonic Adenomas and Timing of Surveillance Colonoscopy Following Solid Organ Transplantation.

Dig Dis Sci 2021 May 10. Epub 2021 May 10.

Department of Medicine, Division of Gastroenterology, School of Medicine and Barnes-Jewish Hospital, Washington University in St. Louis, 660 S Euclid Ave, St Louis, MO, 63110, USA.

Background: Detection and removal of colonic adenomatous polyps (CAP) decreases colorectal cancer (CRC) development, particularly with more or larger polyps or polyps with advanced villous/dysplastic histology. Immunosuppression following solid organ transplantation (SOT) may accelerate CAP development and progression compared to average-risk population but the benefit of earlier colonoscopic surveillance is unclear.

Aims: Study the impact of maintenance immunosuppression post-SOT on developmental timing, multiplicity and pathological features of CAP, by measuring incidence of advanced CAP (villous histology, size ≥ 10 mm, ≥ 3 polyps, presence of dysplasia) post-SOT and the incidence of newly diagnosed CRC compared to average-risk age-matched population. Read More

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Risk of Delayed Bleeding after Cold Snare Polypectomy in Patients with Antithrombotic Therapy.

Dig Dis Sci 2021 May 10. Epub 2021 May 10.

Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, 21-2 Maeda, Tanisawa, Kawahigashi-machi, Aizuwakamatsu-City, Fukushima, 969-3492, Japan.

Background: Cold snare polypectomy is being increasingly adopted; however, there are few reports of cold snare polypectomy regarding antithrombotic therapy.

Aims: This study aimed to investigate the real-world safety of cold snare polypectomy during antithrombotic therapy.

Methods: We collected data from consecutive patients undergoing cold snare polypectomy in a single hospital between 2013 and 2017. Read More

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Impact of second forward-view examination on adenoma detection rate during unsedated colonoscopy: a randomized controlled trial.

BMC Gastroenterol 2021 May 10;21(1):213. Epub 2021 May 10.

China Department of Gastroenterology, Ningbo First Hospital, 59 Liuting St, Ningbo, 315010, Zhejiang, China.

Objectives: Colorectal cancer on the right side of the colon has been suggested to be harder to detect by colonoscopy. The aim of this study was to evaluate whether a second forward-view examination of the right side of the colon could increase the adenoma detection rate (ADR) and/or polyp detection rate (PDR).

Methods: This was a single-centre randomized controlled trial. Read More

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An Ulcerated Large Colic Lipoma Causing Rectorrhagia Treated With Endoscopic Loop-Assisted Resection.

Cureus 2021 Apr 6;13(4):e14321. Epub 2021 Apr 6.

Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, ITA.

Colonic lipomatous polyps are often an incidental finding during colonoscopy. Generally, these types of polyps can cause gastrointestinal bleeding when they are larger than 4 cm in size. Some case reports have documented the occurrence of overlying adenomatous formations in the apical portion, as well as ulcerated mucosa. Read More

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Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden.

BMJ 2021 05 4;373:n877. Epub 2021 May 4.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77 Stockholm, Sweden

Objective: To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC.

Design: Case-control study.

Setting: Linkage to the multi-generation register and gastrointestinal ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) histopathology cohort in Sweden. Read More

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Clinicopathologic Characteristics and Neoplasia Risk of Colorectal Inflammatory Polyposis in Inflammatory Bowel Disease.

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

From the Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Context.—: Inflammatory polyps (IPs) in inflammatory bowel disease may have been associated in the past with increased neoplasia risk. Additionally, colonic mucosa in filiform polyposis and giant inflammatory polyposis may be difficult to visualize during endoscopic surveillance, perhaps contributing to early colectomy in these patients. Read More

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Inverted colonic diverticulum (ICD): report of two cases and literature review of a not that unusual endoscopic challenge.

Clin Res Hepatol Gastroenterol 2021 Apr 27;45(5):101711. Epub 2021 Apr 27.

Gastroenterology and Endoscopy Units, Fondazione "Casa Sollievo della Sofferenza", IRCCS, San Giovanni Rotondo, Italy. Electronic address:

Inverted colonic diverticulum (ICD) is a rare intraluminal lesion occurring in about 0.7-1.7% of people, often endoscopically indistinguishable from polyps. Read More

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