16,028 results match your criteria Colonic Polyps

No-Code Platform-Based Deep-Learning Models for Prediction of Colorectal Polyp Histology from White-Light Endoscopy Images: Development and Performance Verification.

J Pers Med 2022 Jun 12;12(6). Epub 2022 Jun 12.

Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang 10556, Korea.

Background: The authors previously developed deep-learning models for the prediction of colorectal polyp histology (advanced colorectal cancer, early cancer/high-grade dysplasia, tubular adenoma with or without low-grade dysplasia, or non-neoplasm) from endoscopic images. While the model achieved 67.3% internal-test accuracy and 79. Read More

View Article and Full-Text PDF

Synchronous occurrence of different polyp types during colonoscopy.

Aliment Pharmacol Ther 2022 Jun 23. Epub 2022 Jun 23.

Inform Diagnostics, Irving, Texas, USA.

Background: The general probabilities of finding different types of hyperplastic or neoplastic colon lesions clustering in the same patient are unknown. We hypothesised that a systematic analysis of polyp clustering would reveal a high frequency of different concurrent types and that such clustering would be influenced by the underlying histopathology of the individual polyps.

Methods: Using an electronic database of histopathologic records, a cross-sectional study of 2,910,174 colonoscopies evaluated the concordant occurrence of hyperplastic and neoplastic mucosal lesions. Read More

View Article and Full-Text PDF

Is qFIT a useful tool in prioritising symptomatic patients referred with suspect colorectal cancer in the COVID-19 era?

Ulster Med J 2022 May 15;91(2):79-84. Epub 2022 Jun 15.

General and Colorectal Surgical Unit, Ulster Hospital, Dundonald, Belfast, UK.

Background: The COVID-19 pandemic is an evolving healthcare challenge causing secondary disruption of cancer services. Quantitative Faecal Immunochemical Testing (qFIT) has been established as a screening method in asymptomatic patients. We aim to assess its utility as a triage tool to prioritise investigations in symptomatic patients with suspected colorectal cancer. Read More

View Article and Full-Text PDF

Effect of enhanced personal protective equipment on colonoscopy performance and pain linked to procedure during the COVID-19 pandemic.

M Kiyak B Goksoy

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):269-275

Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, University of Health Sciences, Department of General Surgery, Istanbul, Turkey.

Background And Study Aim: During the COVID-19 pandemic, the use of standard personal protective equipment (SPPE) reduces transmission risks during endoscopic procedures. Our aim was to assess the effect of enhanced personal protective equipment (EPPE) on colonoscopy performance and pain linked to the procedure compared with SPPE.

Patients And Methods: During two similar periods with three-month duration (in 2019 and in 2020 during the COVID-19 pandemic), electronic medical records and colonoscopy reports were investigated for sequential patients undergoing colonoscopy. Read More

View Article and Full-Text PDF

Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the mouse model.

Am J Cancer Res 2022 15;12(5):2118-2131. Epub 2022 May 15.

Center for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center Oklahoma City, OK, USA.

Colorectal cancer (CRC) incidence is rising globally. Hence, preventing this disease is a high priority. With this aim, we determined the CRC prevention potential of the TRAIL-inducing small molecule ONC201/TIC10 using a preclinical model representing high-risk familial adenomatous polyposis (FAP) patients, mice. Read More

View Article and Full-Text PDF

In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models.

Biomed Pharmacother 2022 May 5;149:112883. Epub 2022 Apr 5.

Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain; Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18014 Granada, Spain.

Euphorbia lathyris seeds have been used to treat various medical conditions. We previously reported that ethanolic extract from the defatted seed of Euphorbia lathyris (EE) (variety S3201) possesses a potent in vitro antitumor activity against colon cancer (CRC) cell lines. However, the effects of EE on CRC in vivo models and its possible preventive activity have not been elucidated. Read More

View Article and Full-Text PDF

A large family with MSH3-related polyposis.

Fam Cancer 2022 Jun 8. Epub 2022 Jun 8.

Amsterdam UMC location University of Amsterdam, Department of Human Genetics, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

Biallelic MSH3 germline variants are a rare cause of adenomatous polyposis as yet reported in two small families only. We describe the phenotype of a third family, the largest thus far, with adenomatous polyposis related to compound heterozygous MSH3 pathogenic variants. The index patient was a 55-years old male diagnosed with rectal cancer and adenomatous polyposis (cumulatively 52 polyps), with a family history of colorectal polyposis with unknown cause. Read More

View Article and Full-Text PDF

MLH1, BRAF and p53 - searching for significant markers to predict evolution towards adenocarcinoma in colonic sessile serrated lesions.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):971-979

Department of Pathology, Colentina University Hospital, Bucharest, Romania;

Background And Aim: Colonic serrated lesions are premalignant lesions, using an alternative malignization pathway, including multiple genetic and epigenetic alterations, as: mismatch repair deficiency due to MutL homolog 1 (MLH1) promoter methylation, tumor protein p53 (TP53) mutations, activating mutations of v-Raf murine sarcoma viral oncogene homolog B (BRAF) and Kirsten rat sarcoma viral oncogene homolog (KRAS). Our study aims to evaluate MLH1, BRAF and p53 immunohistochemical (IHC) status in sessile serrated lesions (SSLs), with and without dysplasia.

Materials And Methods: This is a retrospective case-control study including 20 SSLs with dysplasia and 20 SSLs without dysplasia (matching sex and age). Read More

View Article and Full-Text PDF

Factors predicting occurrence and therapeutic choice in malignant colorectal polyps: a study of 13 years of colonoscopic polypectomy.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):917-928

Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania;

Colorectal carcinoma represents a major cause of mortality and 0.2-12% of resected colonic polyps have malignant cells inside. We performed a retrospective study of patients with resected polyps during a period of 13 years. Read More

View Article and Full-Text PDF

Polygenic early-onset colorectal cancer in pediatric patients.

Pediatr Blood Cancer 2022 Jun 7:e29790. Epub 2022 Jun 7.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Colorectal cancer in the pediatric population is a rare but transpirable phenomenon. The occurrence should prompt suspicion for underlying genetic mutations in the setting of a hereditary cancer predisposition syndrome. In this series, we outline three pediatric patients with colonic adenocarcinoma who were found to have one or more germline mutations. Read More

View Article and Full-Text PDF

Chemoprevention of Colitis-Associated Dysplasia or Cancer in Inflammatory Bowel Disease.

Gut Liver 2022 Jun 7. Epub 2022 Jun 7.

Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan.

The association between inflammatory bowel disease and colorectal cancer is well known. Although the overall incidence of inflammatory bowel disease has declined recently, patients with this disease still have a 1.7-fold increased risk of colorectal cancer. Read More

View Article and Full-Text PDF

Non-optical polyp-based resect and discard strategy: A prospective clinical study.

World J Gastroenterol 2022 May;28(19):2137-2147

Department of Gastroenterology, Montreal University Hospital Research Center (CRCHUM), Montréal H2X 0A9, Quebec, Canada.

Background: Post-polypectomy surveillance intervals are currently determined based on pathology results.

Aim: To evaluate a polyp-based resect and discard model that assigns surveillance intervals based solely on polyp number and size.

Methods: Patients undergoing elective colonoscopies at the Montreal University Medical Center were enrolled prospectively. Read More

View Article and Full-Text PDF

Familial Adenomatous Polyposis (FAP) Presenting as Iron Deficiency Anemia in a 33-Year-Old Female: A Case Report.

Cureus 2022 Apr 29;14(4):e24603. Epub 2022 Apr 29.

Hematology/Oncology, Florida Cancer Specialists & Research Institute, Sebring, USA.

Iron deficiency anemia is a common clinical concern in women of reproductive age. It presents as microcytic anemia and can be due to a limited number of causes including bleeding, malabsorption, intravascular hemolysis, or a mechanical heart valve. Familial adenomatous polyposis (FAP) is an inherited autosomal dominant disorder due to mutation in the adenomatous polyposis coli () gene that can cause iron deficiency anemia due to GI malignancy, most notably colon cancer. Read More

View Article and Full-Text PDF

c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions.

World J Gastroenterol 2022 Apr;28(13):1338-1346

Edinburgh Inflammatory Bowel Disease Unit, Western General Hospital, NHS Lothian, Edinburgh EH4 2XU, United Kingdom.

Background: Post-colonoscopy colorectal cancer (CRC) rates for patients with inflammatory bowel disease (IBD) are unacceptably high. During colonoscopy, an intravenous fluorescent anti-c-MET probe may improve endoscopic detection of lesions. However, c-MET expression in IBD lesions is poorly defined, limiting translational studies. Read More

View Article and Full-Text PDF

[Clinical features of intestinal polyps and risk factors for secondary intussusception in children: an analysis of 2 669 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2022 May;24(5):530-535

Department of Digestive Nutrition, Hunan Children's Hospital, Changsha 410000, China.

Objectives: To study the clinical features of intestinal polyps and the risk factors for secondary intussusception in children.

Methods: A retrospective analysis was performed for the medical data of 2 669 children with intestinal polyps. According to the presence or absence of secondary intussusception, they were divided into two groups: intussusception (=346) and non-intussusception (=2 323). Read More

View Article and Full-Text PDF

Difference in the prevalence of advanced colon adenoma between patients with gastric neoplasm and healthy people: A STROBE-compliant study.

Medicine (Baltimore) 2022 May 27;101(21):e29308. Epub 2022 May 27.

Department of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine, Busan, South Korea.

Abstract: We compared the prevalence of adenoma and cancerous colon polyps in patients undergoing endoscopic removal or gastric surgery for gastric adenoma or gastric cancer and in healthy individuals.The medical records of 707 patients with gastric neoplasm and 798 age- and sex-matched healthy subjects were retrospectively analyzed between January 2010 and July 2018. The clinicopathological characteristics, prevalence of colorectal neoplasm diagnosed by colonoscopy, and risk factors for colorectal polyps were also investigated. Read More

View Article and Full-Text PDF

Impact of Salvage Surgery following Colonic Endoscopic Polypectomy for Patients with Invasive Neoplasia.

Curr Oncol 2022 04 29;29(5):3138-3148. Epub 2022 Apr 29.

Interdisciplinary Endoscopy Unit, Department of General, Visceral and Transplantation Surgery, University Hospital Tübingen, 72076 Tübingen, Germany.

Background: Invasive neoplasia (Tis-T1) are increasingly being encountered in the daily routine of endoscopic polypectomy. However, the need for salvage surgery following endoscopic therapy for invasive neoplasia is controversially discussed.

Patients And Methods: Patients with endoscopic removal of invasive neoplasia were identified from the national Surveillance Epidemiology and End Results (SEER) Database 2005 to 2015. Read More

View Article and Full-Text PDF

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene.

Genet Res (Camb) 2022 11;2022:1740768. Epub 2022 May 11.

Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh.

POLD1 (DNA polymerase delta 1, catalytic subunit) is a protein-coding gene that encodes the large catalytic subunit (POLD1/p125) of the DNA polymerase delta (Pol) complex. The consequence of missense or nonsynonymous SNPs (nsSNPs), which occur in the coding region of a specific gene, is the replacement of single amino acid. It may also change the structure, stability, and/or functions of the protein. Read More

View Article and Full-Text PDF

Large bowel obstruction caused by a colonic polyp.

J Surg Case Rep 2022 May 23;2022(5):rjac161. Epub 2022 May 23.

Department of Surgery, Suwa Central Hospital, Nagano, Japan.

A large bowel obstruction (LBO) is an emergency condition that requires early diagnosis and prompt treatment, and it is also crucial to identify the cause of the obstruction. Here, we describe a 76-year-old woman who presented to the hospital with a 1-day history of abdominal pain and vomiting and was diagnosed with LBO. Endoscopic findings showed that the cause of the LBO was initially determined to be a Bormann Type I tumour in the sigmoid colon. Read More

View Article and Full-Text PDF

Abdominal pain post-hot snare polypectomy: could it have been avoided?

Endoscopy 2022 06 25;54(6):628. Epub 2022 May 25.

Department of Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK.

View Article and Full-Text PDF

Serrated polyps: innocent or guilty?

Rev Gastroenterol Peru 2021 Oct-Dec;41(4):245-253

Dipartimento di Endoscopia Digestiva e Gastroenterologia, Fondazione Poliambulanza. Brescia, Italy.

Serrated lesions represent a group of lesions with different genetic and biological features causing important clinical repercussions. Three types of serrated lesions are identified: hyperplastic, sessile adenomas (with and without dysplasia) and traditional serrated adenomas. Such lesions are now recognized as precancerous lesions. Read More

View Article and Full-Text PDF

A colorectal cancer missed by colon capsule endoscopy: a case report.

BMC Gastroenterol 2022 May 21;22(1):258. Epub 2022 May 21.

Department of Surgery, Raigmore Hospital, Inverness, UK.

Background: Colon capsule endoscopy (CCE) is a non-invasive alternative to colonoscopy. The reported sensitivity and specificity of CCE for the detection of clinically significant colonic neoplasia is high. To date, there have been no reported cases of colorectal cancer (CRC) missed by CCE which were located in segments adequately visualised by the capsule. Read More

View Article and Full-Text PDF

Estimating colorectal polyp size with a virtual scale endoscope and visual estimation during colonoscopy: Prospective, preliminary comparison of accuracy.

Dig Endosc 2022 May 20. Epub 2022 May 20.

Division of Science and Technology for Endoscopy, National Cancer Center East, Chiba, Japan.

The virtual scale endoscope (VSE) is a new endoscope that helps estimate the size of neoplasms in the gastrointestinal tract. We compared the accuracy of polyp size estimation by VSE with that of visual estimation. A dual center prospective study was conducted in two Japanese academic endoscopy units. Read More

View Article and Full-Text PDF

Is the Presence of Helicobacter Pylori in the Colonic Mucosa, Provocative of Activity in Ulcerative Colitis?

Clin Pathol 2022 Jan-Dec;15:2632010X221096660. Epub 2022 May 12.

Department of Microbiology, College of Science, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.

Background: Epidemiologic studies have shown world-wide increasing incidence of ulcerative colitis (UC) as an autoimmune disease of intestine. In the meantime, gastrointestinal H. Pylori infection is being decreased. Read More

View Article and Full-Text PDF

Comment on "Artificial intelligence in gastroenterology: A state-of-the-art review".

World J Gastroenterol 2022 Apr 28;28(16):1722-1724. Epub 2022 Jan 28.

Department of Surgery, Odense University Hospital, Svendborg 5700, Denmark.

Colon capsule endoscopy (CCE) was introduced nearly two decades ago. Initially, it was limited by poor image quality and short battery time, but due to technical improvements, it has become an equal diagnostic alternative to optical colonoscopy (OC). Hastened by the coronavirus disease 2019 pandemic, CCE has been introduced in clinical practice to relieve overburdened endoscopy units and move investigations to out-patient clinics. Read More

View Article and Full-Text PDF

Acute appendicitis after colorectal endoscopic mucosal resection: a case report.

J Int Med Res 2022 May;50(5):3000605221096273

Department of Gastroenterology, Jingling Hospital, Medical School of Nanjing University, Nanjing, China.

Endoscopic mucosal resection (EMR) was originally described in 1973 and is currently a popular practice used in treating polyps, small adenomas, and early cancers. Although the safety of EMR has been proven in numerous studies, complications occur occasionally. We report a case in which the patient complained of severe upper abdominal pain and who was diagnosed with acute appendicitis after colorectal EMR. Read More

View Article and Full-Text PDF

Management of the malignant colorectal polyp.

Curr Probl Surg 2022 05 10;59(5):101124. Epub 2022 Feb 10.

Department of Surgery, Healthcare Policy and Research, New York-Presbyterian/Weill Cornell Medicine, New York, NY. Electronic address:

View Article and Full-Text PDF

Artificial intelligence assisted optical diagnosis for resect and discard strategy in clinical practice (Artificial intelligence BLI Characterization; ABC study).

Endoscopy 2022 May 13. Epub 2022 May 13.

Gastroenterology Unit, Valduce Hospital, Como, Italy.

Background And Aim: Optical diagnosis (OD) of colonic polyps is poorly reproducible outside high-volume referral centres. Present study aimed to assess whether real-time AI-assisted OD is accurate enough to implement the leave-in-situ strategy for diminutive ( 5mm) rectosigmoid (DRSPs) polyps.

Methods: Consecutive colonoscopy outpatients with 1 DRSP were included. Read More

View Article and Full-Text PDF

Post-traumatic stress disorder is associated with a higher rate of polypectomy independent of an increased frequency of colonoscopy in Australian veterans: a retrospective review.

Intern Med J 2022 May 12. Epub 2022 May 12.

Centre for the Business and Economics of Health, The University of Queensland, Brisbane, Queensland, Australia.

Background: Post-traumatic stress disorder (PTSD) is associated with extensive physical comorbidities, including lower gastrointestinal symptoms. Diagnostic uncertainty and poor therapeutic responses may result in more frequent colonoscopies than clinically necessary. Polypectomy is standard practice when polyps are identified, and if PTSD is a risk factor for polyp formation, one would expect a higher rate of polyp detection and removal in veterans with PTSD than those without PTSD. Read More

View Article and Full-Text PDF

A New Risk-Scoring System for Colorectal Cancer and Polyp Screening by Turkish Colorectal Cancer and Polyp Study Group.

Turk J Gastroenterol 2022 04;33(4):286-293

Department of Gastroenterology, Acıbadem University Faculty of Medicine, İstanbul, Turkey.

Background: Colorectal cancer is one of the most commonly diagnosed types of cancer worldwide. An early diagnosis and detection of colon cancer and polyp can reduce mortality and morbidity from colorectal cancer. Even though there are a variety of options in screen- ing tests, the question remains on which test is the most effective for the early detection of colorectal cancer. Read More

View Article and Full-Text PDF