256,994 results match your criteria Colonic Obstruction


Endoscopic vacuum therapy with open-pore film drainage for colonic anastomotic leakage in a morbidly obese patient.

Endoscopy 2018 Dec 14. Epub 2018 Dec 14.

Department for General, Visceral and Oncological Surgery, Klinikum St. Georg gGmbH, Leipzig, Germany.

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December 2018

An improved rat model for chronic inflammatory bowel disease.

Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:

Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.

Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More

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October 2018

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition. Read More

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December 2018

Inhibition of ASM activity ameliorates DSS-induced colitis in mice.

Prostaglandins Other Lipid Mediat 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address:

Acid sphingomyelinase (ASM) is a membrane lipid hydrolase, acting to generate ceramide and regulate cell functions and inflammatory responses.The roles of ASM in mediating T cell functions are postulated whereas its function in regulation of macrophages remains uncertain. The study was performed to explore ASM activity in control of macrophage functions. Read More

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December 2018

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2018 Dec 11. Epub 2018 Dec 11.

Molecular & Integrative Physiology, University of Michigan School of Public Health, Ann Arbor MI; Internal Medicine Division of Gastroenterology, University of Michigan School of Public Health, Ann Arbor MI; Rogel Cancer Center. University of Michigan Medical School, Ann Arbor MI. Electronic address:

Background & Aims: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis.

Methods: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1) and wild-type littermates (LysMCre;Mcl1, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. Read More

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December 2018

Detection of Malignancy-Associated Phosphoproteome Changes in Human Colorectal Cancer Induced by Cell Surface Binding of Growth-Inhibitory Galectin-4.

IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.

Department of Applied Tumor Biology, Institute of Pathology, Medical School of the Ruprecht-Karls-University, Heidelberg, Germany.

Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium. Read More

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December 2018

Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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December 2018

Diet and colon: what matters?

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Purpose Of Review: Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. This review focuses on dietary patterns to describe the complexity of dietary diversity and overall food consumption and to examine the relationship between dietary patterns and risk of CRC. Read More

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December 2018

Coordination of Care Around Surgery for Colon Cancer: Insights From National Patterns of Physician Encounters With Medicare Beneficiaries.

J Oncol Pract 2018 Dec 14:JOP1800228. Epub 2018 Dec 14.

University of Michigan, Ann Arbor, MI; University of Minnesota, Minneapolis, MN; and University of California San Francisco, San Francisco, CA.

Purpose:: To improve care coordination for complex cancers, it is critical to establish a more nuanced understanding of the types of providers involved. As the number of provider types increases, strategies to support cancer care coordination must adapt to a greater variety of information needs, communication styles, and treatment strategies.

Methods:: We categorized providers into 11 types, using National Provider Identifier specialties. Read More

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December 2018

Use of colony-stimulating factor primary prophylaxis and incidence of febrile neutropenia from 2010-2016: a longitudinal assessment.

Curr Med Res Opin 2018 Dec 14:1-15. Epub 2018 Dec 14.

b Amgen Inc. , Thousand Oaks , CA.

Background: Guidelines recommend primary prophylactic use of colony-stimulating factor (PP-CSF) when risk of febrile neutropenia (FN)-based on chemotherapy and patient risk factors-is high. Whether and how PP-CSF use may have changed over time (e.g. Read More

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December 2018

Cold snare polypectomy: indications, devices, techniques, outcomes and future.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.

Colonoscopy has been shown to reduce the risk of colon cancer by enabling the removal of precancerous lesions. Although the cold snare and hot snare polypectomy have similar retrieval rates and complete resection rates, the rates of delayed bleeding tend to be lower with cold snare polypectomy than with hot snare polypectomy, especially for patients taking antithrombotic agents. However, among cold snares there may be differences in terms of the completeness of polyp excision, as complete removal appears more likely with thin-wire dedicated cold snares compared to the traditional, thick-wire cold snares. Read More

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December 2018

Recipient sepsis caused by Lactococcus garvieae contamination of platelets from a donor with colon cancer.

Vox Sang 2018 Dec 12. Epub 2018 Dec 12.

Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.

Lactococcus garvieae is a well-known fish pathogen that has low virulence in humans and is rarely isolated from the blood cultures of endocarditis patients. We describe herein the first reported case of transfusion-transmitted L. garvieae sepsis caused by a contaminated platelet concentrate from a donor who consumed raw octopus before blood donation. Read More

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December 2018

The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium-induced colitis.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Gastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Background: Ulcerative colitis (UC) is a kind of complex immune disease, the pathogenesis of which remains elusive. Destruction of the intestinal barrier, extreme inflammation, oxidative stress, and apoptosis might play key roles in the development of UC. In previous studies, we observed that Qingchang Wenzhong granule (QCWZG) had the exact effect on the remission of UC in the clinic; however, the underlying mechanism has not been identified. Read More

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December 2018
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β-Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. Read More

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December 2018

Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms.

Authors:
Qing Jiang

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.

The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Read More

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December 2018

TP53 somatic mutations are associated with somatic mitogenome substitutions but not indels in colorectal cancer cells.

J Gene Med 2018 Dec 10:e3063. Epub 2018 Dec 10.

Division of Molecular and Forensic Genetics, Department of Forensic Medicine, Faculty of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Background: p53 is a tumour suppressor protein that is involved in many cancer-related processes. Growing evidence suggests that p53 also plays an important role in mtDNA maintenance. Somatic mitogenome mutations are frequently observed in colorectal cancer cells. Read More

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December 2018

Anti-tumor effects of antibodies to L-type amino-acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes.

Cancer Sci 2018 Dec 10. Epub 2018 Dec 10.

Cell Biology Laboratory, School of Pharmacy, Kindai University, Osaka, Japan.

L-type amino-acid transporter 1 (LAT1) disulfide-linked to the CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In this study, we developed novel anti-LAT1 mAbs, and demonstrated the internalization activity, inhibitory effects of amino acid uptake and cell growth and antibody-dependent cellular cytotoxicity, as well as in vivo anti-tumor effects in athymic mice. Furthermore, we examined the reactivity of mAbs with LAT1 of Macaca fascicularis to evaluate possible side effects of anti-human LAT1 mAbs in clinical trials. Read More

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December 2018

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;35(Spec no2):18-26. Epub 2018 Apr 3.

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Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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Late stent thrombosis after discontinuation of dual anti-platelet therapy in off-label use of paclitaxel-eluting stent visualized by optical coherence tomography-3-vessel OCT study.

J Cardiol Cases 2010 Oct 9;2(2):e67-e70. Epub 2010 Apr 9.

Division of Cardiology, Department of Internal Medicine, Memorial Heart Center, Iwate Medical University, 1-2-1 Chuo-dori, Morioka, Iwate 020-8505, Japan.

We observed late stent thrombosis image by optical coherence tomography (OCT) in vessels with off-label paclitaxel-eluting stents (PES) implantation. A 59-year-old Japanese man was treated with a single on-label PES for chronic coronary artery disease in the left circumflex artery. After 9 months, he was implanted with two linked PESs in the left anterior descending artery (LAD) and a single PES in the right coronary artery (RCA). Read More

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October 2010

Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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December 2018

An Uncommon Presentation of Leiomyoma Cecum as a Subcutaneous Abscess of the Right Flank.

Cureus 2018 Oct 9;10(10):e3432. Epub 2018 Oct 9.

Otolaryngology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cecal leiomyomas are rare benign tumors of smooth muscle arising from the colonic muscularis mucosa or muscularis propria. They are usually asymptomatic in nature and, if symptomatic, may present as pain in the abdomen, intestinal obstruction, or bleeding. In some cases, leiomyoma can cause free perforation leading to peritonitis. Read More

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October 2018
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A Rare Pathological Couplet of Colocolic Intussusception Plus Cecal Bascule in a Young Adult: A Case Report.

Cureus 2018 Oct 9;10(10):e3430. Epub 2018 Oct 9.

Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, AUS.

This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. Subsequently, during the emergency admission and after having an operative surgical procedure, the patient was found to have both a congenitally malpositioned cecum and a benign colonic polyp-forming condition. Read More

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October 2018

A novel prognostic prediction model for recurrence in patients with stage II colon cancer after curative resection.

Mol Clin Oncol 2018 Dec 4;9(6):697-701. Epub 2018 Oct 4.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

The present study aimed to clarify the risk factors for recurrence of stage II colon cancer in patients and to determine possible treatment options for postoperative adjuvant chemotherapy. A prediction model for recurrence in patients with stage II colon cancer after curative surgical resection was developed. The present study retrospectively investigated 436 patients who underwent curative resection for stage II colon cancer at Osaka International Cancer Institute and Yao Municipal Hospital between 2004 and 2012. Read More

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December 2018

Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review.

Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More

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December 2018

Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases.

Mol Clin Oncol 2018 Dec 5;9(6):587-591. Epub 2018 Oct 5.

Department of Surgical Oncology, Gifu University School of Medicine, Gifu, Gifu 501-1194, Japan.

Pathological complete response is achievable with mFOLFOX6 plus cetuximab therapy for unresectable colorectal cancer with multiple paraaortic lymph node metastases (mCRC) despite right-sided colonic origin. A 62-year-old woman with synchronous paraaortic lymph node metastases of transverse colon cancer was treated with mFOLFOX6 plus cetuximab as first-line therapy. The tumor size was markedly decreased following 6 courses of chemotherapy, and all lymph node metastases had disappeared. Read More

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December 2018

Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood.

Oncotarget 2018 Nov 16;9(90):36166-36184. Epub 2018 Nov 16.

Bioscience, Respiratory, Inflammation and Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden.

As we learn more about how immune responses occur , it is becoming clear that each organ/tissue is characterized with its own anatomy and microenvironment which may affect and even determine the outcome of the immune responses. With emerging data from animal studies showing that regulatory T cells infiltrating non-lymphoid tissues exhibit unique phenotypes and transcriptional signatures and display functions beyond their well-established suppressive roles, there is an urgent need to explore the function of tissue Treg cells in humans. Here we characterized the transcriptome of Treg residing at the human mucosal tissue obtained from the normal area of cancer resections and their peripheral blood counterparts, identifying human lung and colon tissue Treg signature genes and their upstream regulators. Read More

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November 2018

Inhibition of breast cancer metastasis to the lungs with UBS109.

Oncotarget 2018 Nov 16;9(90):36102-36109. Epub 2018 Nov 16.

Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.

Synthetic monocarbonyl analogs of curcumin (MACs) are cytotoxic against several cancers including head and neck cancer, pancreatic cancer, colon cancer, and breast cancer. Mechanisms of action include depolarization of the mitochondrial membrane potential and inhibition of NF-κB, leading to apoptosis. We previously demonstrated that UBS109 (MAC), has preventive effects on bone loss induced by breast cancer cell lines. Read More

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November 2018

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.

Oncol Lett 2018 Dec 28;16(6):7264-7270. Epub 2018 Sep 28.

Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.

With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. Read More

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December 2018

Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells.

Oncol Lett 2018 Dec 28;16(6):7175-7179. Epub 2018 Sep 28.

Department of Gastrointestinal Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

This study investigated the role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Fifty-five patients with colon cancer who were treated in China-Japan Union Hospital of Jilin University from March 2014 to March 2015 were enrolled into this study. Their cancer and corresponding paracancerous tissues were collected and the expression levels of miR-214 were determined by RT-qPCR. Read More

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December 2018

Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128.

Exp Ther Med 2018 Dec 28;16(6):4824-4830. Epub 2018 Sep 28.

Department of Nursing, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan 423000, P.R. China.

A previous study implied that long intergenic non-coding RNA 1410 (LINC01410) promotes angiogenesis and metastasis of gastric cancer. However, the role of LINC01410 in colon cancer (CC) has remained elusive. In the present study, LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. Read More

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December 2018

Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Exp Ther Med 2018 Dec 19;16(6):4445-4456. Epub 2018 Sep 19.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. Read More

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December 2018

Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.

Pathologica 2018 Sep;110(2):111-115

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, Policlinico Universitario-Vittorio Emanuele, University of Catania, Italy.

Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. Read More

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September 2018

Internal Hernia Associated with Colostomy After Laparoscopic Surgery for Rectal Malignancy: A Report of 3 Thought-Provoking Cases.

Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More

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December 2018

Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival.

Methods: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. Read More

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December 2018

Central 5-hydroxytryptamine (5-HT) mediates colonic motility by hypothalamus oxytocin-colonic oxytocin receptor pathway.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Department of Physiology and Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address:

Gut-derived 5-hydroxytryptamine (5-HT) is well known for its role in mediating colonic motility function. However, it is not very clear whether brain-derived 5-HT is involved in the regulation of colonic motility. In this study, we used central 5-HT knockout (KO) mice to investigate whether brain-derived 5-HT mediates colonic motility, and if so, whether it involves oxytocin (OT) production in the hypothalamus and OT receptor in the colon. Read More

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December 2018

Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium.

Comp Med 2018 Dec 13. Epub 2018 Dec 13.

Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycinand metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function,cytokine and chemokine profiles, and neutrophil migration in colon tissue. Azithromycin treatment significantly reduced theseverity of colitis, as assessed through body weight change, water consumption, macroscopic lesions, and animal behaviors(activity level, climbing, and grooming), but did not alter food consumption or feeding behavior. Read More

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December 2018

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;0(0):18-26. Epub 2018 Apr 3.

.

Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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April 2018
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Survival and quality of life after surgery for colorectal cancer in the elderly: a comparative study.

Rev Esp Enferm Dig 2018 Dec 14;111. Epub 2018 Dec 14.

Hospital Germans Trias i Pujol.

Background: the aim of this study was to analyze the clinical results of the multidisciplinary management of elderly patients with colorectal cancer in a single center and to describe postoperative quality of life.

Methods: a comparative study was designed to compare the results and quality of life of patients treated in our center for colon cancer, aged from 80 to 84 years (study group) compared to a control group (aged form 75 to 79 years of age). Morbidity, mortality, oncological results and quality of life were analyzed. Read More

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December 2018

Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil.

Inflammatory bowel disease is triggered by an uncontrolled immune response associated with genetic, environmental, and intestinal microbiota imbalance. Ipomoea asarifolia (IA), popularly known as "salsa" or "brave salsa", belongs to the Convolvulaceae family. The aim of this approach was to study the preventive effect of IA aqueous extract in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rats. Read More

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December 2018

Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.

Authors:
Carolyn M Klinge

Noncoding RNA 2018 Dec 12;4(4). Epub 2018 Dec 12.

Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40292, USA.

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes, including levels and activity of estrogen receptor α (ERα), proliferation, invasion, migration, apoptosis, and stemness. In addition, ncRNAs can be packaged into exosomes to provide intercellular communication by the transmission of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) to cells locally or systemically. Read More

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December 2018

Gut Microbiota, Fusobacteria, and Colorectal Cancer.

Diseases 2018 Dec 11;6(4). Epub 2018 Dec 11.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the entire alimentary tract (5). Recently, the concept that a normal bacterial microbiota is essential for the development of inflammation-induced carcinoma has emerged from studies of well-known colonic bacterial microbiota. Read More

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December 2018

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive oxygen species (ROS) levels. Investigating the anti-cancer properties of novel 1,8-naphthalimide derivatives containing Rh(I) and Ru(II) -heterocyclic carbene (NHC) ligands, we observed a profound induction of ROS by the complexes, which is most likely generated from mitochondria (mtROS). Read More

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December 2018

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins.

Cells 2018 Dec 10;7(12). Epub 2018 Dec 10.

Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.

The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (HSP27) is a chaperone that interacts with many proteins. Read More

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December 2018

Flavonoids and Colorectal Cancer Prevention.

Antioxidants (Basel) 2018 Dec 10;7(12). Epub 2018 Dec 10.

Division of Hematology & Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Abor, MI 48109, USA.

Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related mortality. Prevention may, therefore, be a key strategy in reducing colorectal cancer deaths. Given reports of an inverse association between fruit and vegetable consumption with colorectal cancer risk, there has been significant interest in understanding the metabolism and bioactivity of flavonoids, which are highly abundant in fruits and vegetables and account for their pigmentation. Read More

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December 2018

Spatial-Temporal Analysis of PM and NO₂ Concentrations Collected Using Low-Cost Sensors in Peñuelas, Puerto Rico.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

Region 2, U.S. Environmental Protection Agency, Edison, NJ 08837-3679, USA.

The U.S. Environmental Protection Agency (EPA) is involved in the discovery, evaluation, and application of low-cost air quality (AQ) sensors to support citizen scientists by directly engaging with them in the pursuit of community-based interests. Read More

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December 2018

Cardiac tamponade after radiofrequency ablation for hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Dec;97(49):e13532

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA. Read More

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December 2018
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Quality of life of patients with a colonic interposition postoesophagectomy.

Eur J Cardiothorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastro-Intestinal Surgery, Ghent University Hospital, Ghent, Belgium.

Objectives: After oesophagectomy, stomach grafts are most frequently used to restore intestinal continuity. Less frequently, a colonic graft is used. There is quite a large body of literature addressing the functional outcome after gastric pull-up, but little is known about the functional results of colonic interposition (CI). Read More

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December 2018

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon.

Eur Surg Res 2018 Dec 13;59(5-6):371-379. Epub 2018 Dec 13.

The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More

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December 2018

Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.

Int Immunopharmacol 2018 Dec 10;67:129-137. Epub 2018 Dec 10.

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (Jiang Su Province Hospital of Traditional Chinese Medicine), Nanjing 210029, China. Electronic address:

Gallic acid (GA), as an active component, has been found in many fruits and plants, and it exhibits potential protective effects, such as anti-inflammatory, antioxidant, antiviral and anticancer. However, the effects of GA on ulcerative colitis (UC) remain unknown. The purpose of this study was to investigate the effects of GA on IL-1β-induced HIEC-6 cells and TNBS-induced UC in mice. Read More

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December 2018

Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program.

Eur J Cancer 2018 Dec 10;107:53-59. Epub 2018 Dec 10.

Epidemiology and Evaluation Department, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; REDISSEC (Health Services Research on Chronic Patients Network), Madrid, Spain.

Introduction: Increased values in the fecal immunochemical test (FIT) are correlated with increasingly severe colorectal neoplasia, but little attention has been given to FIT values below the cut-off point (negative FIT, nFIT). We analysed the relationship between the concentrations of two consecutive nFIT and the risk of following screen-detected advanced neoplasia and interval cancer (IC) in a population-based colorectal cancer screening program.

Methods: FIT results were categorised into non-detectable nFIT (0-3. Read More

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December 2018