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Public Health Genomics 2018 Dec 6:1-8. Epub 2018 Dec 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Aim: To develop a process for returning medically actionable genomic variants to Latino patients receiving care in a Federally Qualified Health Center.

Methods: Prior to recruitment, researchers met with primary care providers to (1) orient clinicians to the project, (2) establish a process for returning actionable and nonactionable results to participants and providers through the electronic health record, and (3) develop a process for offering clinical decision support for follow-up education and care. A Community Advisory Board was engaged to provide input on recruitment strategies and materials for conveying results to participants. Read More

Int J Surg Case Rep 2018 Nov 22;54:51-54. Epub 2018 Nov 22.

Department of Surgery, Epworth Health, Melbourne Australia; Gastrointestinal Clinical Institute, Epworth HealthCare, Melbourne Australia.

Introduction: There is a known association between Clostridium Septicum, mycotic aneurysm and colon neoplasm.

Case Presentation: We report the case of a 90 year old female admitted with abdominal pain to the general surgery unit. Admission CT scan demonstrated a thick walled caecum and pericaecal inflammation suspicious for a perforated carcinoma. Read More

Biomed Pharmacother 2018 Dec 3;110:312-318. Epub 2018 Dec 3.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically been notable worldwide and many attempts have been made to raise the overall survival of CRC patients. Immune response has long been a question of great interest in a wide range of fields such as cancer therapies and anti-tumor immunity through checkpoint inhibitors, specifically anti PD-1/ PD-L1 interaction, is a new line of research for treatment of CRC patients. Following the successful development of anti-PD-1 for melanoma, renal cell carcinoma, and non-small cell lung cancer, several clinical trials have been conducted on monoclonal antibodies (MAbs) against PD-1 in CRC. Read More

Clin Imaging 2018 Nov 30;54:31-36. Epub 2018 Nov 30.

Trabzon Kanuni Education and Research Hospital, Department of Radiology, 61080 Trabzon, Turkey.

Purpose: To investigate the relationship between gastric wall fat halo sign and visceral obesity with potentially associated diseases.

Materials And Methods: Between September 2015 and April 2017, 90 patients with gastric wall fat halo signs and 130 controls were prospectively evaluated. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), percentage of visceral fat (VF%) and the presence of colic or ileal fat halo signs, hepatic steatosis and aortic calcified plaques were recorded for the two groups. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Fisetin is a natural flavonoid with promising antitumor activity, whereas its clinical application is limited by its hydrophobic property. In this study, we aimed to load fisetin into poly(lactic acid) (PLA) nanoparticles to increase fisetin's solubility and therapeutic efficacy. Based on spontaneous emulsification solvent diffusion (SESD) method, the formulation of PLA nanoparticles was optimized by two successive experimental designs. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea. Electronic address:

Colorectal cancer is the third most diagnosed cancer and a leading cause of cancer death. Dissatisfaction with currently available anti-colorectal cancer drugs caused by unwanted side effects and low efficacy necessitates new therapeutic agents. In the present study, a sulfated glucuronorhamnoxylan polysaccharide (named SPS-CF) purified from a green alga Capsosiphon fulvescens was evaluated for its anti-cancer activity in vitro and in vivo against colorectal cancer. Read More

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background & Aims: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (age <50 years) adults, in 2 time periods.

Methods: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons ages 20 - 54 years) from 1992 through 2014, for different time periods (1992-1996 vs 2010-2014) and races (white vs black). Read More

Gastrointest Endosc 2018 Dec 3. Epub 2018 Dec 3.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Background And Aims: Delayed bleeding is an important adverse event after colorectal endoscopic submucosal dissection (ESD). We aimed to investigate the incidence and risk factors of delayed bleeding after colorectal ESD, and to develop a risk scoring model for predicting delayed bleeding.

Methods: This retrospective multicenter study was performed at 5 centers. Read More

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):395-409. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Endocrinología Experimental. Ciudad de México, México

More than 70% of the population in Mexico is overweight or obese, affecting mainly people in productive age. Obesity is associated with the development of diseases that increase cardiovascular risk (diabetes mellitus, hypertension or atherogenic dyslipidemia), diseases that limit the quality of life of the patient (osteoarthrosis or sleep apnea) and even with the increase in the incidence of certain types of cancer (breast or colon). It is evident that the decrease of at least 5% of body weight induces improvement in all these factors; however, in some patients it is difficult to achieve this goal only with lifestyle modifications. Read More

Folia Med Cracov 2018 ;58(3):83-87

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Meckel's diverticulum represents a remnant of the proximal end of the omphalomesenteric duct, which constitutes a connection between the middle intestine and the vitelline vesicle. It is the most common congenital anomaly of the gastrointestinal tract and is found in approximately 0.3-2% of the general population. Read More

Acta Med Port 2018 Nov 30;31(11):661-669. Epub 2018 Nov 30.

Serviço de Cirurgia Geral. Hospital Garcia de Orta. Almada. Portugal.

Introduction: Approximately 20% - 30% of histological lymph node-negative patients with colorectal cancer relapse at five years after surgical treatment. This recurrence is likely due to occult nodal disease undetected by standard histopathological practice which has implications in terms of the clinical management of patients.

Material And Methods: Lymph nodes were collected from colectomy specimens. Read More

FASEB J 2018 Dec 6:fj201802018R. Epub 2018 Dec 6.

Division of Life Sciences, Korea University, Seoul, South Korea.

Extracellular vesicles contain various cellular components that are involved in tumor growth, metastasis, and immune escape. Extracellular vesicles are classified into 2 groups, namely, exosomes and microvesicles (MV). Although the formation and roles of exosomes have been studied, the exact functions of MVs and mechanisms underlying MV release are not fully understood. Read More

Mol Nutr Food Res 2018 Dec 6:e1800985. Epub 2018 Dec 6.

R. Pei, D. A. Martin, J. C. Valdez, J. Liu, B. W. Bolling, University of Wisconsin-Madison, Department of Food Science,, 1605 Linden Dr., Madison, WI, 53706, USA.

Scope: Increased fruit consumption is associated with reduced risk of colitis. We investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') were mediated through Th17 and Treg.

Methods And Results: Colitis was induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4 CD62L naïve T cells. Read More

Mol Oncol 2018 Dec 6. Epub 2018 Dec 6.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge of CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Read More

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downregulated circRNAs in colon cancer tissues. Read More

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

College of Medicine and Public Health & Centre for Neuroscience, Flinders University, Australia.

Normal gut function relies on the activity of the enteric nervous system (ENS) found within the wall of the gastrointestinal tract. The structural and functional organisation of the ENS has been extensively studied in the guinea pig small intestine, but less is known about colonic circuitry. Given that there are significant differences between these regions in function, observed motor patterns and pathology, it would be valuable to have a better understanding of the colonic ENS. Read More

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7 Kita-ku, Sapporo, 060-8638, Japan.

Background: Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.

Methods: Altogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. Read More

Biomed Res Int 2018 4;2018:9701957. Epub 2018 Nov 4.

Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.

Aim: Colon cancer-associated transcript-1 (CCAT1), located in the vicinity of transcription factor c-Myc, was first identified in colon cancer. A small-molecule compound CX3543 (Quarfloxin) selectively targeting Myc G-quadruplexes has entered phase II clinical trials for neuroendocrine carcinomas. The aim of the study was to explore the relationship between CX3543, CCAT1, and cell apoptosis in colon cancer cells. Read More

Ann Med Surg (Lond) 2018 Dec 22;36:235-238. Epub 2018 Nov 22.

Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi, India.

Metastatic tumors to stomach are extremely rare with very few cases being described so far in the surgical literature. Colonic tumors metastatic to stomach represent a rarer entity and present a surgical challenge for diagnosis and management to the clinician. We, hereby present a case of adenocarcinoma of transverse colon metastatic to stomach more than 6 years after the index malignancy, presenting clinically with features of gastric outlet obstruction. Read More

Patholog Res Int 2018 4;2018:2638258. Epub 2018 Nov 4.

Department of Gastroenterology and Hepatology, University Medical Center Brandenburg, Brandenburg, Germany.

Primary eosinophilic gastroenteritis and colitis (EGE) is a rare entity with unspecific clinical and endoscopic findings. Validated histopathologic criteria for confirming the diagnosis are lacking, because numeric values for normal or elevated concentrations of eosinophils in mucosal biopsies are varying between observers. To quantify this interobserver variance, we had the same set of 30 slides of eosinophilic-rich mucosal biopsies from the ileum and colon systematically reviewed by a panel of six independent pathologists, each with more than a ten-year experience in the field. Read More

Cancer Manag Res 2018 13;10:5629-5638. Epub 2018 Nov 13.

Department of Colorectal Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China,

Background: Neuroendocrine tumors (NETs) are a group of heterogeneous cancers arising from a variety of anatomic sites. Their incidence has increased in recent years. This study aimed to analyze the prognosis of NETs originating from different anatomic sites. Read More

Cancer Manag Res 2018 8;10:5479-5490. Epub 2018 Nov 8.

Department of General Surgery, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004 People's Republic of China,

Background And Aims: SMAD4, as a tumor suppressive gene in human colon cancer, inhibits the metastasis of colon adenocarcinoma cells. However, the molecular mechanisms are unclear. miRNAs play an important role in the pathogenesis and progression of cancer. Read More

Sci Rep 2018 Dec 5;8(1):17639. Epub 2018 Dec 5.

Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.

Sox2 is known as the undifferentiated cell marker. Recent studies have shown that Sox2 may also be involved in the maintenance of cancer stem cells (CSCs) in skin and bladder cancers. In this study, we aimed to clarify the role of Sox2 in colorectal CSCs. Read More

Cell Death Dis 2018 Dec 5;9(12):1176. Epub 2018 Dec 5.

Jiangsu Cancer Biotherapy Institute, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China.

Hepatocellular carcinoma-related protein-1 (HCRP-1), a subunit of mammalian endosomal sorting complex required for transport-I (ESCRT-I), is frequently downregulated in various kinds of malignant tumors. The role of HCRP-1 in colorectal cancer (CRC) remains unknown. We investigate the clinical value of HCRP-1 and its impact on anoikis in CRC. Read More

Sci Rep 2018 Dec 5;8(1):17640. Epub 2018 Dec 5.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

In this study, lecithin-stabilized polymeric micelles (LPMs) were prepared to load quercetin (QUE) in order to improve its bioavailability and increase its antitumor activity. Its combination with doxorubicin (DOX) to minimize DOX-mediated cardiac toxicity and increase the antitumor activity of QUE-loaded LPMs was also examined. LPMs were prepared following a previously reported procedure. Read More

Dtsch Arztebl Int 2018 Oct;115(43):715-722

Institute for General Medicine, Faculty of Medicine, University of Halle-Wittenberg, Halle; Institute for Health and Nursing Sciences, Faculty of Medicine, University of Halle-Wittenberg, Halle; Director Emeritus, Department of Medicine C, Ludwigshafen Hospital, c/o LebensBlicke Foundation, Ludwigshafen; Department of Internal Medicine I, Ulm University Hospital, Ulm; Department of Medicine I, Braunschweig Municipal Hospital, Braunschweig; Department of Gastroenterology, Celle General Hospital, Celle; Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen; Faculty of Human and Health Sciences, University of Bremen; Institute for Medical Epidemiology, Biometrics, and Information Science, Faculty of Medicine, University of Halle-Wittenberg, Halle; Nursing Research Unit, Halle University Hospital, Halle: Madeleine Ritter-Herschbach, MScN, RN; Department for Health, University of Bath, Claverton Down, Bath, UK.

Background: Screening colonoscopy can lower the incidence of colorectal cancer (CRC), yet participation rates are low even in groups at high risk. The goal of this study was to double the rate of participation in screening colonoscopy among persons at familial risk and then to determine the frequency of neoplasia in this risk group.

Methods: In a nationwide, cluster-randomized, multicenter study, first-degree relatives (FDR) of patients with CRC across Germany received written informational materials concerning the familial risk of CRC, along with an invitation to undergo colonoscopy. Read More

Am J Chin Med 2018 Dec 6:1-19. Epub 2018 Dec 6.

* Neurobiota Research Center and Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.

A variety of products have been developed with red ginseng (RG, the steamed roots of Panax ginseng Meyer). To clarify the immunomodulating effects of water-extracted RG (wRG), 50% ethanol-extracted RG (eRG), enzyme-treated eRG (ERG) and probiotic-fermented eRG (FRG), we examined their immunopotentiating and immunosuppressive effects in mice with cyclophosphamide (CP)-induced immunosuppression (CI) or 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (TC). Oral administration of RG in CI mice significantly increased blood IFN- levels. Read More

Bioorg Chem 2018 Oct 23;82:423-430. Epub 2018 Oct 23.

Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt. Electronic address:

Anticancer therapeutics with profiles of high potency, low toxicity, and low resistance is of considerable interest. A new series of functionalized spirooxindole linked with 3-acylindole scaffold is reported, starting from chalcones derived from 3-acetyl indole with isatin, and l-4-thiazolidinecarboxylic acid. The reactions proceeded regioselectivity, stereoselectivity, without side products in high yield (71-89%). Read More

Peptides 2018 Nov 30. Epub 2018 Nov 30.

Department of Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, United States. Electronic address:

The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach and intestine which involves both central and peripheral nervous systems. The expression and function of GLP-1R in gastrointestinal smooth muscle, however, are not clear. Read More

Lancet Gastroenterol Hepatol 2018 Dec;3(12):884

University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

J Aging Phys Act 2018 Dec 3:1-16. Epub 2018 Dec 3.

a Mitochondrial Biology and Radiation Research Centre, Department of Life Sciences, Institute of Technology Sligo, Ash Lane, Sligo, Co. Sligo, Ireland.

Telomeres act as a mitotic clock and telomere related senescence has been linked to age related physiological decline. There is increasing evidence lifestyle factors can influence telomere length. The purpose of this study was to determine the effect of competitive triathlon training on telomere length. Read More

J Am Geriatr Soc 2018 Dec 2. Epub 2018 Dec 2.

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Background/objectives: Over a million older patients in the United States are admitted yearly for emergency general surgery (EGS) conditions. Seven procedure types dominate: colon, small bowel, gallbladder, ulcer disease, adhesiolysis, appendix, and laparotomy operations. A higher comorbidity burden is known to increase mortality in this population, but the impact of specific comorbidity combinations is unknown. Read More

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: Altered expression of microRNAs (miRNAs) is indicated strongly in colorectal cancer (CRC). This study aims to evaluate the inhibitory role of miR-193a-5p on epithelial-mesenchymal transition markers in CRC lines. The cellular effects and potential mechanisms of miR-193a-5p were also examined. Read More

Colorectal Dis 2018 Dec;20(12):1069

Department of Colon & Rectal Surgery, Cleveland Clinic Florida, Weston, FL, USA.

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1285-1290

Department of General Surgery, Fudan University Affliated Zhongshan Hospital, Shanghai 200032, China. Email:

Objective: To investigate the levels of serum inflammatory cytokines and Resolvin D1 (RvD1) and their association with pathological staging of colon cancer.

Methods: Clinical data of 50 colon cancer patients (colon cancer group) admitted to the General Surgery Department of Zhongshan Hospital of Fudan University from January to December 2016 and 5 ml of whole blood specimen were collected at admission. During the same period, 50 healthy volunteers were enrolled (healthy volunteer group). Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1261-1267

Department of Colorectal Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Objective: To explore the prognostic factors of patients with unresectable liver metastasis colorectal cancer after failed conversion chemotherapy.

Methods: A retrospective, case-controlled study was performed. Study subjects were 105 patients who were diagnosed with synchronous liver metastasis colorectal cancer after failed chemotherapy (metastasis evaluated as unresectable after the conversion chemotherapy) at Xinhua Hospital, Shanghai Jiaotong University from January 2012 to December 2015. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1255-1260

Department of Colorectal Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Email:

Objective: To explore the safety and feasibility of the overlapped delta-shaped anastomosis (ODA) technique for cases undergoing totally laparoscopic right hemicolectomy (TLRH).

Methods: Clinical data of patients who underwent TLRH using the ODA technique or the modified delta-shaped anastomosis (MDA) technique at Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College from January 2016 to December 2017 were retrospectively analyzed.

Inclusion Criteria: (1)diagnosed with adenocarcinoma by enteroscopy before operation; (2)cancer locating at ascending colon or transverse colon hepatic region and receiving TLRH surgery. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

Pflugers Arch 2018 Dec 1. Epub 2018 Dec 1.

Institute for Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.

Acetylcholine and atypical esters of choline such as propionyl- and butyrylcholine are produced by the colonic epithelium and are released when epithelial receptors for short-chain fatty acids (SCFA) are stimulated by propionate. It is assumed that the SCFA used by the choline acetyltransferase (ChAT), the central enzyme for the production of these choline esters, originate from the colonic lumen, where they are synthesized during the bacterial fermentation of carbohydrates. Therefore, it seemed to be of interest to study whether the non-neuronal cholinergic system in the colonic epithelium is affected by maneuvers intended to stimulate or to inhibit colonic fermentation by changing the intestinal microbiota. Read More

Transl Gastroenterol Hepatol 2018 22;3:79. Epub 2018 Oct 22.

Academic Department of Surgery, University of Birmingham, Birmingham, UK.

Transl Gastroenterol Hepatol 2018 12;3:76. Epub 2018 Oct 12.

Division of Gastroenterology, Department of Internal Medicine and Department of Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109-5368, USA.

Endosc Int Open 2018 Dec 29;6(12):E1410-E1412. Epub 2018 Nov 29.

Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Division of Gastroenterology, Long Island Jewish Medical Center, New Hyde Park, New York, United States.

 This is a case report on use of the CryoBalloon as a salvage technique for ablation of residual neoplasia at an endoscopic mucosal resection site. The site contained an embedded clip that could not be removed at two different sessions by three experienced endoscopists. On follow-up endoscopy, the clips and residual polyp no longer remained. Read More

Endosc Int Open 2018 Dec 23;6(12):E1406-E1409. Epub 2018 Nov 23.

Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

 Colon interposition for benign strictures is associated with significant perioperative complications that carry high morbidity and mortality. Although rarely reported in the literature, adenocarcinoma can occur as a late complication in an interposed colonic segment. We report a case of a late-stage adenocarcinoma in a colonic interposition performed for benign esophageal stricture. Read More

Transl Lung Cancer Res 2018 Dec;7(6):616-630

Thermo Fisher Scientific, Waltham, Massachusetts, USA.

Background: Tumor mutational burden (TMB) is an increasingly important biomarker for immune checkpoint inhibitors. Recent publications have described strong association between high TMB and objective response to mono- and combination immunotherapies in several cancer types. Existing methods to estimate TMB require large amount of input DNA, which may not always be available. Read More

Urol Case Rep 2019 Mar 15;23:10-12. Epub 2018 Nov 15.

Department of Surgery - Division of Urology, 1 Hospital Drive, MC 301E, Columbia, MO, 65212, USA.

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Read More

J Gastrointest Oncol 2018 Oct;9(5):828-832

Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer.

Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Read More

J Gastrointest Oncol 2018 Oct;9(5):778-784

Medical Oncology, Cancer Treatment Centers of America, Philadelphia, PA, USA.

Background: Prior reports have demonstrated inferior outcomes for patients with right-sided colorectal cancer (CRC) compared to patients with left-sided disease, as well as differences in treatment response based on disease sidedness. Differences in prognosis remain even among patients with metastatic disease, indicating that anatomy or stage at diagnosis alone cannot explain all of these findings. While genetic differences between right- and left-sided CRC have long been described, the genetic and molecular drivers underlying differences in prognosis and treatment response remain incompletely understood. Read More

Front Microbiol 2018 16;9:2780. Epub 2018 Nov 16.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin. As cobalamin has several forms, the effects of different forms of cobalamin on gut microbiota were investigated in this study. Read More