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Dig Endosc 2022 May 20. Epub 2022 May 20.

Division of Science and Technology for Endoscopy, National Cancer Center East, Chiba, Japan.

The virtual scale endoscope (VSE) is a new endoscope that helps estimate the size of neoplasms in the gastrointestinal tract. We compared the accuracy of polyp size estimation by VSE with that of visual estimation. A dual center prospective study was conducted in two Japanese academic endoscopy units. Read More

Cancer Med 2022 May 20. Epub 2022 May 20.

Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

The mRNA vaccine has provided a promising approach for cancer immunotherapies. However, only a few mRNA vaccines have been developed against colon adenocarcinoma (COAD). Screening potential targets for mRNA vaccines from numerous candidates is a substantial challenge. Read More

Cureus 2022 Apr 16;14(4):e24175. Epub 2022 Apr 16.

Medical Oncology, Ankara University School of Medicine, Ankara, TUR.

Aim To assess the actionable genomic landscape of colon adenocarcinoma in the primary and metastatic tumor tissues. Methods The data from the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) were used in this study. Colon adenocarcinoma patients with primary and metastatic tissue samples (distant organ and lymph node) were selected. Read More

Mod Pathol 2022 May 19. Epub 2022 May 19.

Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.

Mucinous adenocarcinoma (MAD), the most common subtype of colonic adenocarcinoma (CA), requires >50% intratumoral mucin. There is limited data regarding the impact of MAD on key lymphocyte subsets and therapeutically critical immune elements. In this study we address: (1) the definition of MAD, (2) grading of MAD, and (3) the impact of MAD and extracellular mucin on intratumoral immune milieu. Read More

Biomed Res Int 2022 9;2022:6770135. Epub 2022 May 9.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.

Objectives: Lotus leaf is rich in flavonoids, and this study is aimed at examining the inhibitory effect of lotus leaf-enriched flavonoid extract (LLEFE) on HT-29 colon cancer cells through phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) expression regulation.

Methods: Lotus leaves were extracted by ethanol and purified using FL-3 macroporous resin to create the LLEFE. HT-29 colon cancer cells were tested using various methods: their proliferation was observed by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, their survival status was observed by fluorescence staining, their oxidative stress level was observed by biochemical kits, and their mRNA expression was determined by quantitative polymerase chain reaction (qPCR) assay. Read More

ACS Med Chem Lett 2022 May 19;13(5):786-791. Epub 2022 Apr 19.

Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China.

Diosgenin, a component separated from Dioscorea plants, is an important starting material for steroid hormone drugs and semisynthetic steroids. In the work, two series of diosgenin derivatives were designed, synthesized, and evaluated for their cellular anticancer activities. Most of the target compounds exhibited good inhibitory activities against four cell lines, Aspc-1 (human colon adenocarcinoma cells), H358 (human nonsmall cell lung cancer cells), HCT116 (human colorectal adenocarcinoma cells), and SW620 (human metastatic pancreatic cancer cells). Read More

Surg Case Rep 2022 May 19;8(1):101. Epub 2022 May 19.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.

Background: Locoregional recurrence and metastasis to the liver, peritoneum, and lung are the most common recurrent patterns of pancreatic ductal adenocarcinoma (PDAC) after radical resection. Recurrence in the abdominal wall is extremely rare. Herein, we report our experience with a patient who had recurrent PDAC in the abdominal wall with long-term survival by means of multidisciplinary therapy. Read More

JNCI Cancer Spectr 2022 May;6(3)

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

Background: Human studies investigating the prospective relationship between microbial metabolites and colorectal cancer (CRC) risk are lacking. We tested whether higher serum bile acids (BAs) and lower short-chain fatty acids (SCFAs) were associated with CRC risk.

Methods: In baseline serum collected more than 30 years before a CRC diagnosis, we quantified concentrations of 15 BAs and 6 SCFAs using targeted liquid chromatography with tandem mass spectrometry  assays in 1:1 matched cases and controls from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial (men: n = 262 cases; women: n = 233 cases) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (men: n = 598 cases). Read More

World J Gastroenterol 2022 Apr 28;28(16):1722-1724. Epub 2022 Jan 28.

Department of Surgery, Odense University Hospital, Svendborg 5700, Denmark.

Colon capsule endoscopy (CCE) was introduced nearly two decades ago. Initially, it was limited by poor image quality and short battery time, but due to technical improvements, it has become an equal diagnostic alternative to optical colonoscopy (OC). Hastened by the coronavirus disease 2019 pandemic, CCE has been introduced in clinical practice to relieve overburdened endoscopy units and move investigations to out-patient clinics. Read More

Nat Commun 2022 May 17;13(1):2710. Epub 2022 May 17.

Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.

Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, information on mutation rates in normal tissues and understanding of the trajectory from normal to cancer cell is limited. Here we whole genome sequence 152 crypts from normal and neoplastic epithelial tissues from 10 LS patients. Read More

Gan To Kagaku Ryoho 2022 May;49(5):593-596

Dept. of Surgery, Nippon Medical School Hospital.

Late-stage elderly patients have low tolerance to chemotherapy, and they have difficulties when they are treated with standard chemotherapy. We report a case of a late-stage elderly patient who had a long-term response to UFT/UZEL/bevacizumab( Bev)therapy for lung metastasis after surgery for early-stage colon cancer. He was 82-years-old and underwent laparoscopy-assisted sigmoid colectomy for sigmoid colon cancer at another hospital. Read More

Gan To Kagaku Ryoho 2022 May;49(5):589-592

Dept. of Surgery, Tsuyama Chuo Hospital.

Oral uracil and tegafur plus Leucovorin(UFT/LV)therapy is one of the standard adjuvant chemotherapies for colorectal cancer, and is widely used without any serious adverse events. Herein, we describe a case of UFT/LV-induced acute liver failure in a 75-year-old woman who underwent laparoscopic sigmoidectomy for sigmoid colon cancer. She was diagnosed with advanced colon cancer and lymph node metastasis by postoperative histopathological analysis, and adjuvant chemotherapy was initiated. Read More

Cancer Cell Int 2022 May 16;22(1):190. Epub 2022 May 16.

Department of General Surgery, The First Affiliated Hospital With Nanjing Medical University, 300 Guanzhou Road, Nanjing, 210029, China.

Extracellular vesicles secreted by tumor microenvironment (TME) cells are vital players in tumor progression through transferring nucleic acids and proteins. Macrophages are the main immune cells in TME and tumor associated macrophages (TAM) express M2 phenotype, which induce tumor proliferation, angiogenesis, invasion, metastasis and immune elimination, resulting in the subsequent evolution of malignancies. There are a high number of studies confirmed that tumor cells and TAM interact with each other through extracellular vesicles in various cancers, like pancreatic ductal adenocarcinoma, gastric cancer, breast cancer, ovarian cancer, colon cancer, glioblastoma, hepatocellular cancer, and lung cancer. Read More

Enferm Infecc Microbiol Clin (Engl Ed) 2022 May;40(5):221-223

Unidad de Enfermedades Infecciosas, Hospital Lucus Augusti, Lugo, Spain.

J Int Med Res 2022 May;50(5):3000605221096273

Department of Gastroenterology, Jingling Hospital, Medical School of Nanjing University, Nanjing, China.

Endoscopic mucosal resection (EMR) was originally described in 1973 and is currently a popular practice used in treating polyps, small adenomas, and early cancers. Although the safety of EMR has been proven in numerous studies, complications occur occasionally. We report a case in which the patient complained of severe upper abdominal pain and who was diagnosed with acute appendicitis after colorectal EMR. Read More

Cancer Sci 2022 May 16. Epub 2022 May 16.

Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, China.

HDACs are involved in many processes including tumor cell growth and proliferation and regulation of gene expression. To clarify the role of Class IIa HDACs in the metastasis of colon adenocarcinoma, we used the Class IIa HDAC inhibitor TMP269 and found that it effectively inhibited the migration ability of colon adenocarcinoma cells. Next, we silenced the member of Class IIa HDACs and confirmed that the migratory ability of colon adenocarcinoma cells was significantly inhibited by silencing HDAC5 or HDAC7. Read More

Comput Math Methods Med 2022 4;2022:7525048. Epub 2022 May 4.

Institute of Digestive Disease, Zhengzhou University, Zhengzhou, 450014 Henan, China.

Colon adenocarcinoma (COAD) is a common digestive tract tumor. Autophagy-related genes (ARGs) may play an obbligato role in the biological processes of COAD. This study was aimed at exploring the role of ARGs in COAD. Read More

Front Microbiol 2022 28;13:833154. Epub 2022 Apr 28.

Botany and Microbiology Department, Faculty of Science, Tanta University, Tanta, Egypt.

Biosynthesized silver nanoparticles (Bio-SNPs) were synthesized from the marine actinobacterium strain M2 and characterized using a variety of techniques, including UV-vis spectrum, fourier transform infrared spectroscopy (FTIR), energy dispersive x-ray (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), surface-enhanced Raman spectroscopy (SERS), and zeta potential. The antibacterial activity of Bio-SNPs alone and in combination with antibiotic was evaluated using a microtiter-dilution resazurin assay against multidrug-resistant (MDR) bacteria. Bio-SNPs' minimum inhibitory concentration (MIC) against bacterial strains was determined. Read More

Front Immunol 2022 28;13:802665. Epub 2022 Apr 28.

Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Purpose: To construct an immune-related gene prognostic index (IRGPI) for colon cancer and elucidate the molecular and immune characteristics as well as the benefit of immune checkpoint inhibitor (ICI) therapy in IRGPI-defined groups of colon cancer.

Experimental Design: Transcriptional and clinical data of colon cancer samples were obtained from The Cancer Genome Atlas (TCGA) (n = 521). Immune-related genes were obtained from ImmPort and InnateDB databases. Read More

Front Immunol 2022 28;13:875764. Epub 2022 Apr 28.

Laboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), EA7269, Université Bourgogne Franche-Comté, Dijon, France.

Immunotherapy has allowed major advances in oncology in the past years, in particular with the development of immune checkpoint inhibitors, but the clinical benefits are still limited, particularly in colorectal cancer (CRC). Our scientific approach is based on the search for innovative immunotherapy with a final goal that aims to induce an effective antitumor immune response in CRC. Here, we focused on a multikinase inhibitor, H89. Read More

Front Pharmacol 2022 27;13:875016. Epub 2022 Apr 27.

Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Thailand.

Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for healthcare personnel and patients alike. Read More

Am J Case Rep 2022 May 16;23:e935920. Epub 2022 May 16.

Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.

BACKGROUND Colorectal cancer among pregnant women is a rare entity. If colon cancer is suspected during pregnancy, the diagnosis is a therapeutic challenge that should be managed by a multidisciplinary team of specialists. Standardized therapeutic models do not exist. Read More

BMC Gastroenterol 2022 May 15;22(1):247. Epub 2022 May 15.

Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.

Purpose: Perforation and obstruction in colorectal cancer are poor prognostic factors. We aimed to evaluate the oncological outcomes of patients with colon cancer presenting with perforation or obstruction.

Methods: A total of 260 patients underwent surgery for colon cancer between January 2015 and December 2017. Read More

Int J Surg Case Rep 2022 May 10;95:107179. Epub 2022 May 10.

Caribbean Colon Cancer Initiative, St James, Barbados; Department of Surgery, Queen Elizabeth Hospital, St Michael, Barbados. Electronic address:

Introduction: Herbal medicine plays a significant role in modern medicine. The difficulty in integrating the two, lies in the unknown quantities of active ingredients in herbal remedies. This proved true in this clinical scenario. Read More

Curr Probl Surg 2022 05 10;59(5):101124. Epub 2022 Feb 10.

Department of Surgery, Healthcare Policy and Research, New York-Presbyterian/Weill Cornell Medicine, New York, NY. Electronic address:

Molecules 2022 May 5;27(9). Epub 2022 May 5.

School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

This study aimed to investigate the inhibitory effects and mechanism of diaporthein B (DTB), a natural compound extracted from the fungus Penicillium sclerotiorum GZU-XW03-2, on human colon cancer cells. The inhibitory effect of DTB at different concentrations on the proliferation of colon cancer cells HCT116 and LOVO was detected at 24 and 48 h. The effect of cell migration and clone formation ability were detected by cell scratch and plate cloning experiments. Read More

Nutrients 2022 May 3;14(9). Epub 2022 May 3.

School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

In our previous research, -12 alleviated inflammation in dextran sodium sulfate (DSS)-induced mice by regulating intestinal microbiota and preventing colon shortening ( < 0.05). The purpose of the present study was to evaluate whether -12 could ameliorate the colon cancer symptoms of azoxymethane (AOM)/DSS-treated C57BL/6 mice. Read More

Nutrients 2022 Apr 20;14(9). Epub 2022 Apr 20.

Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China.

The selenylated polysaccharides chemically belong to the organic Se-conjugated macromolecules and have recently been attracting more and more attention due to their potential to promote body health or prevent cancers. Longan ( L.), as a subtropical fruit, contains soluble and non-digestible polysaccharides that are regarded with health care functions in the body. Read More

Cells 2022 Apr 29;11(9). Epub 2022 Apr 29.

School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, UK.

Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the growth of colon cancer cells. However, the exact role of crocin on the angiogenesis and metastasis in colorectal cancer remains unclear. Read More

Cells 2022 Apr 27;11(9). Epub 2022 Apr 27.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial cell-cell adhesions is a hallmark of intestinal inflammation contributing to epithelial injury, repair, and tumorigenesis. P-cadherin is an important adhesion protein, poorly expressed in normal intestinal epithelial cells (IEC) but upregulated in inflamed and injured mucosa. Read More