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Cell 2019 Feb;176(5):1098-1112.e18

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5) cancer stem cells and promote an adenoma-to-adenocarcinoma progression. Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-β-muricholic acid (T-βMCA) and deoxycholic acid (DCA), induce proliferation and DNA damage in Lgr5 cells. Read More

PLoS One 2019 20;14(2):e0211477. Epub 2019 Feb 20.

Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia pathway. Although SAC prognosis is not widely recognized, the serrated pathway-associated subtype consistently exhibits unfavorable prognosis in genetic studies. Herein, we classified molecularly distinct subtypes of serrated adenocarcinomas and clarified their associated clinicopathological characteristics and genetic changes. Read More

Mol Cell Biol 2019 Feb 19. Epub 2019 Feb 19.

Program of Immunology and Tumor Biology, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil.

Intracellular lipid accumulation has been associated with poor prognosis in cancer. We have previously reported the involvement of lipid droplets in cell proliferation in colon cancer cells, suggesting a role for these organelles in cancer development. Here, we evaluate the role of lipid droplets in cell cycle regulation and cellular transformation. Read More

Int J Surg Case Rep 2019 Feb 10;55:233-238. Epub 2019 Feb 10.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: The resection of a primary colon cancer has the opportunity to cure the patient of cancer by complete clearance and absolute containment of disease. Alternatively, if the cancer resection does not provide clearance and containment it will eventuate in local recurrence and peritoneal dissemination.

Methods: Culpability of recurrence of colorectal cancer is difficult to determine. Read More

Sci Rep 2019 Feb 15;9(1):2165. Epub 2019 Feb 15.

Institute of Medical Biology, PAS, 106 Lodowa Street, 93232, Lodz, Poland.

Epithelial-to-mesenchymal transition (EMT) in cancer cells, represents early stages of metastasis and is a promising target in colorectal cancer (CRC) therapy. There have been many attempts to identify markers and key pathways induced throughout EMT but the process is complex and depends on the cancer type and tumour microenvironment. Here we used the colon cancer cell line HT29, which stably overexpressed Snail, the key transcription factor in early EMT, as a model for colorectal adenocarcinoma cells with a pro-metastatic phenotype. Read More

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry, Faculty of Science, Firat University, Elazig, Turkey.

1,2,4-Triazoles are used as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many 1,2,4-triazoles continue to be synthesized. In this study, the effect of the 1,2,4-triazole derivatives on human colon cancer (HT29) was investigated in vitro and in vivo in rats. Read More

Abdom Radiol (NY) 2019 Feb 14. Epub 2019 Feb 14.

Department of Molecular Medicine and Surgery Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Introduction/background: The aim of the study was to assess morphological predictors for lymph node metastases (Stage III disease) in colon cancer on computed tomography.

Methods And Materials: Ninety-four patients with histology-proven colon cancer (adenocarcinoma) who underwent elective primary curative resection between the years 2012 and 2014 were included. Contrast-enhanced CT examinations were independently reviewed by two blinded observers regarding tumor location, depth of tumor invasion, and presence of lymph node metastases. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):139-141

Dept. of Surgery, Toyama City Hospital.

A 56-year-old man was admitted to our hospital because abdominal CT showed wall thickening of the ascending colon. Colonoscopyshowed type 4 colon cancer, diagnosed as poorlydifferentiated adenocarcinoma bybiopsy , with circumferential stenosis. Enhanced CT after admission also showed obstructive ileus and lymphadenopathy leading to a paraaortic lesion, but no other distant metastases were seen. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):136-138

Dept. of Surgery, Fuchu Hospital.

A67 -year-old man was diagnosed with ascending colon cancer and multiple liver metastases and underwent laparoscopic right hemicolectomy(D3 lymphadenectomy). Pathological examination indicated tubular adenocarcinoma(tub1, pT4apN2H2M1[HEP], pStage Ⅳ). After chemotherapy, he underwent hepatectomy. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):115-117

Dept. of Gastroenterology and Surgery, Sano City Hospital.

A 78-year-old man was referred to our hospital with diarrhea, melena, and weight loss. During a digital rectal examination, a protuberant mass located 7-8 cm above the anal verge was palpable. Computed tomography(CT)scans of his chest, abdomen, and pelvis revealed an intestinal obstruction with a target sign in the lower rectum, indicating intussusception due to a sigmoid colon mass. Read More

Front Immunol 2019 29;10. Epub 2019 Jan 29.

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.

Layilin (LAYN) is a critical gene that regulates T cell function. However, the correlations of LAYN to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. LAYN expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. Read More

Cell Tissue Res 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Medicine, Department of Medical Biology, Ege University, Izmir, Turkey.

In the current experiment, the combined regime of resveratrol and a Wnt-3a inhibitor, sulindac, were examined on the angiogenic potential of cancer stem cells from human colon adenocarcinoma cell line HT-29 during 7 days. Cancer stem cells were enriched via a magnetic-activated cell sorter technique and cultured in endothelial induction medium containing sulindac and resveratrol. Expression of endothelial markers such as the von Willebrand factor (vWF) and vascular endothelial cadherin (VE-cadherin) and genes participating in mesenchymal-to-epithelial transition was studied by real-time PCR assay. Read More

World J Clin Cases 2019 Feb;7(3):335-339

Department of General Surgery, Beijing Chaoyang Hospital affiliated to Capital Medical University, Beijing 100020, China.

Background: Surgery 5-10 d after stent insertion was recommended by the European Society of Gastrointestinal Endoscopy for obstructing colonic cancer. For some obstructive patients, this may be not a good choice. Here, we report the successful treatment of obstructing colonic cancer by combining self-expandable stent and neoadjuvant chemotherapy. Read More

Cells 2019 Feb 10;8(2). Epub 2019 Feb 10.

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), 01309 Dresden, Germany.

In highly aggressive malignancies like pancreatic cancer (PC), patient-derived tumor models can serve as disease-relevant models to understand disease-related biology as well as to guide clinical decision-making. In this study, we describe a two-step protocol allowing systematic establishment of patient-derived primary cultures from PC patient tumors. Initial xenotransplantation of surgically resected patient tumors (n = 134) into immunodeficient mice allows for efficient in vivo expansion of vital tumor cells and successful tumor expansion in 38% of patient tumors (51/134). Read More

Cancer Lett 2019 Feb 8. Epub 2019 Feb 8.

Institute of Physiology, Pathophysiology and Toxicology, Centre of Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Strasse 12, Witten, Germany. Electronic address:

Oncogenic pituitary homeobox 2 (PITX2), a de facto master regulator of developmental organ asymmetry, previously upregulated multidrug resistance (MDR) P-glycoprotein (ABCB1) in A498 renal cell carcinoma (RCC) cells. The role of PITX2 isoforms in MDR cancers was investigated. Data mining correlated elevated PITX2 in >30% of cancers analyzed, maximally in colon (4. Read More

Dis Colon Rectum 2019 Mar;62(3):294-301

Division of Colon and Rectal Surgery, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Canada.

Background: Endorectal brachytherapy is an attractive option in the neoadjuvant setting for locally advanced rectal cancer, but it is not considered standard of care.

Objective: This study aimed to compare pathologic outcomes of patients with clinical T3 rectal cancer who underwent high-dose-rate endorectal brachytherapy with those who underwent conventional external beam radiotherapy.

Design: This study is a retrospective chart review. Read More

Int J Surg Case Rep 2019 Jan 31;55:168-170. Epub 2019 Jan 31.

Division of Surgery, Hiraka General Hospital, Yokote, Akita, Japan.

Introduction: Most transitional cell carcinomas (TCCs) occur in the urinary tract. There are no reports of TCC originating in the colon. This report presents a very rare case of TCC that primarily occurred in the colon. Read More

J Surg Res 2019 Feb 5;238:35-40. Epub 2019 Feb 5.

Good Samaritan General Surgery Residency Program, Cincinnati, Ohio; TriHealth Cancer Institute, Cincinnati, Ohio. Electronic address:

Background: Previous studies using the NSQIP database to study hepatectomies lacked hepatic specific variables and outcomes. We used the targeted NSQIP hepatectomy database to examine the nationwide trend and the safety profile of synchronous liver and colorectal resection compared with hepatectomy alone for colorectal liver metastasis.

Methods: The targeted NSQIP hepatectomy database from 2014 was used to study patients who underwent hepatectomy for diagnosis of adenocarcinoma of the colon and rectum. Read More

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.

Background: Competitive endogenous RNA (ceRNA) regulation suggested complex network of all transcript RNAs including long noncoding RNAs (lncRNAs), which can act as natural miRNA sponges to inhibit miRNA functions and modulate mRNA expression. Until now, the specific ceRNA regulatory mechanism of lncRNA-miRNA-mRNA in colorectal cancer (CRC) still remains unclear.

Materials And Methods: RNA sequencing data of 478 colon adenocarcinoma cases and 41 controls as well as 166 rectum adenocarcinoma cases and 10 controls were obtained from The Cancer Genome Atlas (TCGA) to investigate the significant changes of lncRNAs, miRNAs and mRNAs in colorectal carcinogenesis. Read More

Gynecol Oncol Rep 2019 May 29;28:15-17. Epub 2019 Jan 29.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

We report an extraordinary case of a woman, exposed to diethylstilbestrol in utero, who developed clear cell adenocarcinoma of the cervix with a concurrent polymerase-Ɛ () somatic mutation. The tumor exhibited the classic phenotypic characteristics of -mutated tumors originating from other organs (e.g. Read More

Orv Hetil 2019 Feb;160(6):228-234

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6720.

Li-Fraumeni syndrome is a rare genetic disorder predisposing the individual to multiple different cancer types, caused by a germline mutation of the TP53 or CHEK2 genes inherited in an autosomal dominant manner. We hereby describe the case of a family with Li-Fraumeni syndrome. An asymptomatic 40-year-old female was diagnosed with primary lung leiomyosarcoma (T3N0), adenocarcinoma (T1aN0), and inflammatory myofibroblastic tumor, which were surgically removed without further treatment. Read More

Case Rep Oncol Med 2019 6;2019:6958952. Epub 2019 Jan 6.

School of Medicine, CES University, Medellín, Colombia.

We report a case of a 52-year-old female with a family history of pancreatic and colon cancers who presented with a right breast mass positive for high-grade medullar carcinoma with triple-negative biomolecular profile. Further workup was performed finding a left ovarian mass. The patient underwent laparotomy performing optimal cytoreduction on bilateral ovarian tumors; the pathology and immunohistochemistry confirmed bilateral ovary adenocarcinoma with positive peritoneal malignancy. Read More

Biomolecules 2019 Feb 4;9(2). Epub 2019 Feb 4.

Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università degli Studi di Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.

Fruits and vegetables are a good source of potentially biologically active compounds. Their regular consumption in the human diet can help reduce the risk of developing chronic diseases such as cardiovascular diseases and cancer. Plants produce additional chemical substances when subject to abiotic stress or infected by microorganisms. Read More

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

The distal metastasis is the main cause of death in patients with colon cancer. Tyrosine receptor kinase B (TrkB) and ERK signals may be the potential targets for the treatment of colon cancer metastasis. This study aims to investigate whether erlotinib inhibits distant metastasis of colon cancer by regulating TrkB and ERK signaling pathway. Read More

PLoS One 2019 4;14(2):e0211507. Epub 2019 Feb 4.

Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

BAP1 is a tumor suppressor gene important to the development and prognosis of many cancers, especially uveal melanoma (UM). Its role in more common cancers such as breast and colon cancer is largely unknown. We collected the transcriptome profiling data sets from the TCGA uveal melanoma (TCGA-UVM), breast cancer (TCGA-BRCA), and colon cancer (TCGA-COAD) projects to analyze the expression of BAP1. Read More

Mol Oncol 2019 Feb 3. Epub 2019 Feb 3.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy.

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Therapies that take advantage of defects in DNA repair pathways have been explored in the context of breast, ovarian, and other tumor types, but not yet systematically in CRC. At present, only immune checkpoint blockade therapies have been FDA approved for use in mismatch repair deficient colorectal tumors. Read More

J Gastrointest Cancer 2019 Feb 4. Epub 2019 Feb 4.

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Background: Survivin is a member of the inhibitor of an apoptosis protein family that has been shown to inhibit apoptosis, promote cell proliferation and enhance angiogenesis. In this study, the survivin protein expression in normal, colon polyp, and adenocarcinoma tissues was investigated.

Methods: Immunohistochemical staining for nuclear survivin was carried out on 45 normal colon tissue samples, 38 samples of a colonic polyp, and 37 cases of colon adenocarcinoma operated by colonoscopy or colectomy. Read More

Curr Pathobiol Rep 2018 Sep 16;6(3):193-198. Epub 2018 Jul 16.

Department of Pathology, University of Southern California Keck School of Medicine,

Purpose Of Review: Recent studies demonstrate that normal human tissues accumulate substantial numbers of somatic mutations with aging, to levels comparable to their corresponding cancers. If mutations cause cancer, how do tissues avoid cancer when mutations are unavoidable?

Recent Findings: The small intestines (SI) and colon accumulate similar numbers of replication errors, but SI adenocarcinoma is much rarer than colorectal cancer. Both the small and large intestines are subdivided into millions of small neighborhoods (crypts) that are maintained by small numbers of stem cells. Read More

Cancer Immunol Res 2019 Feb 1. Epub 2019 Feb 1.

Surgery Branch, National Cancer Institute.

Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here we report the identification and characterization in one patient of T cell receptors (TCRs) recognizing mutated p53 p. Read More

Immunopharmacol Immunotoxicol 2019 Feb 1:1-7. Epub 2019 Feb 1.

h National Laboratory Animal Center , National Applied Research Laboratories , Taipei , Taiwan.

Objective: Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated colorectal cancer (CAC). Previous studies have indicated that the composition of gut microflora may be involved in CAC induction and progress. Bacteroides fragilis (BF) is a Gram-negative anaerobe belonging to colonic symbiotic bacteria of the host. Read More

Sci Rep 2019 Jan 31;9(1):1074. Epub 2019 Jan 31.

Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.

Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):73-78

Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060,

Objective: To investigate the evaluation value of preoperative peripheral blood lymphocyte-to-monocyte ratio (LMR) on the prognosis of patients with stage III colon cancer undergoing radical resection and postoperative adjuvant chemotherapy.

Methods: Electronic medical record were retrospectively retrived for stage III colon cancer patients who underwent radical surgery at Sun Yat-sen University Cancer Center from December 2007 to December 2013. Inclusion criteria were pathologically comfirmed colon adenocarcinoma, complete clinicopathological data, and postoperative XELOX (oxaliplatin + capecitabine) chemotherapy with follow-up of at least 3 months. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):35-42

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510155, China.Email:

Objective: To evaluate the short-term efficacy and cosmetic effect of dual-port laparoscopic distal gastrectomy (DPLDG) for gastric cancer.

Methods: Thirty consecutive patients underwent DPLDG at the Department of General Surgery, Nanfang Hospital from November 2016 to August 2018.

Inclusion Criteria: (1) age of 18 to 75 years; (2) primary gastric adenocarcinoma confirmed pathologically by endoscopic biopsy; (3) tumor located at middle-low stomach and planned for distal gastrectomy; (4) cT1b-2N0-1M0 at preoperative staging; (5) tumor diameter ≤3 cm; (6) US Eastern Cancer Cooperative Group(ECOG) score 0 to 1 points; (7) American Society of Anesthesiologists grade I to II; (8) perioperative management based on enhanced recovery after surgery (ERAS) principle. Read More

J Ethnopharmacol 2019 Jan 29;235:28-37. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

Ethnopharmacological Relevance: Fagara tessmannii Engl. is an African medicinal plant used in Cameroonian traditional medicine to treat various types of cancers.

Aim Of The Study: This work was designed to determine the cytotoxicity of the crude extract (FTB), fractions (FTBa-d) and compounds isolated from the bark of Fagara tessmannii, namely lupeol (1), fagaramide (2), zanthoxyline (3), hesperidin (4), nitidine chloride (5), fagaridine chloride (6), and β-sitosterol-3-O-β--glucopyranoside (7). Read More

Medicine (Baltimore) 2019 Feb;98(5):e14326

Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79# Qingchun Road.

Rationale: Colorectal cancer (CRC) is one of the most common cancers all over the world, and approximately 70% of the newly diagnosed patients are over 65 years old. Due to the aging of society, there will be more and more elderly patients of CRC in the future. Treatment of CRC in elderly patients is much more challenging thanks to multiple factors including disabling comorbidities as well as declines in organs function, especially in advanced or metastatic settings. Read More

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans.

Methods: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Read More

Eur J Immunol 2019 Jan 29. Epub 2019 Jan 29.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

The role of IL-10 in malignant pleural effusion (MPE) remains unknown. By using murine MPE models, we observed that an increase in pleural IL-10 was a significant predictor of increased risk of death. We noted that T 1- and T 17-cell content in MPE was higher in IL-10 mice than in WT mice, and IL-10 deficiency promoted differentiation into T 1 but not into T 17 cells. Read More

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Headington, Oxford, United Kingdom.

Faecal occult blood (FOB) - based screening programmes for colorectal cancer detect about half of all cancers. Little is known about individual health behavioural characteristics which may be associated with screen-detected and interval cancers. Electronic linkage between the UK National Health Service Bowel Cancer Screening Programme (BCSP) in England, cancer registration and other national health records, and a large on-going UK cohort, the Million Women Study, provided data on 628,976 women screened using a guaiac-FOB test (gFOBt) between 2006 and 2012. Read More

Can J Surg 2019 Feb;62(1):E4-E6

From the Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Kloos, Keren, Gregg, Dixon, Rochon, Ball); and the Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB (Mohamed).

Summary: Delays in the diagnosis and treatment of colon adenocarcinoma are distressing to patients and clinicians alike. Of 224 patients with resected colon cancer identified via a province-wide administrative database, 170 (76%) received their colonoscopy from a gastroenterologist (GI). Patients waited significantly longer between their colonoscopy and surgical resection when the colonoscopy was performed by a GI within an urban city (43 v. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2461-2463

Dept. of Surgery, Tsuyama Chuo Hospital.

A 71-year-old man visited our hospital because ofepigastralgia and anorexia. Upper gastrointestinal endoscopy revealed type 1 gastric cancer. Contrast-enhanced abdominal CT revealed gastric wall thickening in the midgastric region and direct invasion ofthe transverse colon. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2447-2449

Dept. of Surgery, Japan ease Red Cross Kobe Hospital.

A 90-year-old male underwent total gastrectomy for gastric cancer 10 months earlier. The cancer was pathologically diagnosed as Stage ⅢA. Preoperative serum CA19-9 level was as high as 1,326 U/mL, but quickly decreased after surgery. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2387-2389

Dept. of Surgery, Fuchu Hospital.

A 79-year-old woman was admitted to the hospital because of continuous right lower abdominal pain lasting for 1 day. There was tenderness with signs of peritoneal irritation at the right lower abdomen along with a palpable mass. With the diagnosis of intussusception of the ileocecal region by CT examination, an emergency surgery was performed under general anesthesia. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2330-2332

Dept. of Surgery, Reimeikai Kitade Hospital.

An 80-year-old woman with peritoneal dissemination after laparoscopic right hemicolectomy for appendicular carcinoma (mucinous adenocarcinoma, pT4aN1M0, stage Ⅲa)underwent CapeOX plus bevacizumab chemotherapy. The patient achieved stable disease over 5 courses of the treatment. Subjective and objective symptoms were not observed; however, chest computed tomography findings revealed a thrombus in the pulmonary artery that was considered to be associated with bevacizumab. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1877-1879

Dept. of Surgery, Ogikubo Hospital.

The patient was a man in his 40s, who had undergone laparoscopic ileocecal resection with lymph node dissection(D3)for cecal cancer in January 2012. Histopathological examination of the resected specimens had revealed StageⅡ primary tumor with subserosal invasion and positive metastasis in 1-3 regional lymph nodes(pT2[SS]n1[+]). The pathological stage was Ⅲa(fStage Ⅲa), and the tumor showed RAS gene mutation. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2264-2266

Dept. of Surgery, Kyoundo Hospital.

A 65-year-old woman underwent high anterior resection for sigmoid colon cancer in 2011. The histopathological diagnosis was type 2, 25×27 mm, tub2, SE, N2, ly2, v1, and Stage Ⅲb. Her treatment was completed after 6months of adjuvant chemotherapy with UFT plus UZEL followed by a 5-year follow-up study, without recurrence. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2258-2260

Dept. of Gastrointestinal Tract Surgery, Fukushima Medical University.

A 69-year-old female was admitted to our hospital due to general malaise and appetite loss. On physical examination, a tumor was palpable in the upper left abdomen. A complete blood count revealed anemia. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2229-2231

Dept. of Surgery, Hannan Chuo Hospital.

We present an interesting case in which a patient diagnosed with primary peritoneal cancer after the resection of a greater omentum mass achieved recurrence-free survival without postoperative systemic chemotherapy. The patient was a 78-yearold woman with no history ofmalignant disease. She underwent abdominal ultrasound at a local clinic, which revealed a mass shadow near the descending colon. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2075-2077

Dept. of Surgery, Kashiwa Kousei General Hospital.

A 60s man with a history of laparoscopic distal gastrectomy(LDG)of gastric cancer in January 2015was followed up in an outpatient clinic. He remained healthy without recurrence for about 2 years, but in February 2017, colonoscopy identified an elevated lesion that covered one-third of the circumference in the ascending colon. Biopsy revealed that this lesion had poorly differentiated adenocarcinoma. Read More

J Surg Res 2019 Mar 23;235:22-33. Epub 2018 Oct 23.

Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, P.R. China; Department of General Surgery, Lanzhou General Hospital of Chinese People's Liberation Army, Lanzhou, Gansu, P.R. China. Electronic address:

Background: Accumulating evidence indicated that long noncoding RNAs (lncRNAs) have a wide range of biological functions and may play significant roles in tumorigenesis and progression. However, the understanding of its functions and related competitive endogenous RNAs (ceRNAs) networks is much less than that of protein-coding genes, particularly in colon adenocarcinoma.

Methods: We comprehensively analyzed the sequencing data of protein-coding and noncoding RNAs in colon adenocarcinoma patients from The Cancer Genome Atlas (TCGA) database. Read More

Nat Prod Res 2019 Jan 29:1-8. Epub 2019 Jan 29.

a UoN Chair of Oman's Medicinal Plants and Marine Natural Products , University of Nizwa , Nizwa , Sultanate of Oman.

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-β-boswellic acid (AKBA, 1) 11-keto-β-boswellic acid (KBA, 2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Read More