Search Our Scientific Publications & Authors

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.

Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (MCF-7, MDA-MB-231, SK-BR-3), human colon adenocarcinoma (HT-29), human cervix adenocarcinoma (HeLa), human prostate adenocarcinoma (PC-3), Mus musculus neuroblastoma (Neuro 2A) cell lines and African green monkey kidney (VERO) as healthy cell line. Supercritical CO extracts proved to be more active than soxhlet counterparts. Read More

Sci Rep 2019 Apr 17;9(1):6212. Epub 2019 Apr 17.

Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Republic of Korea.

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated the effectiveness of conditionally ablating PKM2 in Lgr5 intestinal stem cells (ISC) using a mouse model of colitis-associated CRC (AOM plus DSS). Read More

Med Image Anal 2019 Apr 4;55:1-14. Epub 2019 Apr 4.

Department of Computer Science, University of Warwick, UK; Department of Pathology, University Hospitals Coventry and Warwickshire, UK; The Alan Turing Institute, UK. Electronic address:

Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles (PHPs). For a given image patch, the homology profiles are derived by efficient computation of persistent homology, which is an algebraic tool from homology theory. Read More

Surg Case Rep 2019 Apr 15;5(1):61. Epub 2019 Apr 15.

Department of Surgery, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634-8522, Japan.

Background: Solitary adrenal metastasis from colorectal cancer is rare. Adrenal metastasis is usually detected with synchronous multiple metastases in other organs and is, therefore, considered to be unsuitable for surgical resection. The long-term outcomes of patients with solitary adrenal metastasectomy from colorectal cancer have been reported; however, the survival advantage has not been established. Read More

J Endourol Case Rep 2019 18;5(1):13-15. Epub 2019 Mar 18.

Department of Urology, New York Medical College, Valhalla, New York.

Secondary malignancies of the ureter are uncommon. We report the diagnosis and management of metastatic colon cancer to the bifurcation of a bifid ureter. A 59-year-old man presented with diffuse metastasis with right hydronephrosis in both renal moieties of a partially duplicated system and an enhancing lesion within the proximal common ureter. Read More

World J Gastrointest Oncol 2019 Jan;11(1):59-70

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto ON, Canada.

Aim: To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.

Methods: The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised.

Results: GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. Read More

Chem Pharm Bull (Tokyo) 2019 Apr 13. Epub 2019 Apr 13.

Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University.

Eighteen novel chalcone derivatives containing indole and naphthalene moieties (2-19) were synthesized and characterized by H NMR, C NMR and HRMS spectra. All compounds were evaluated for their in vitro cytotoxic potential against human hepatocellular carcinoma (HepG2), human colon carcinoma (HCT116) and human breast adenocarcinoma (MCF-7) cell lines. Among them, compound 2, 3, 4 and 7 showed potent activities against tested cancer cell lines. Read More

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Epithelial cell polarity regulator Crumbs3 (Crb3), a mammalian homolog within the Drosophila Crb gene family, was initially identified as an essential embryonic development factor. It is recently implicated in tumor suppression, though its specific functions are controversial. We here demonstrate that Crb3 strongly promotes tumor invasion and metastasis of human colon adenocarcinoma cells. Read More

Methods Mol Biol 2019 ;1977:3-15

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

The technology of "sequential windowed acquisition of all theoretical fragment ion spectra," known as SWATH-MS, is rapidly gaining popularity as a next generation proteomics technology for comprehensive proteome quantitation. In this chapter, we describe the use of SWATH-MS as a label-free quantitative technique in a proteomics study to identify novel serological biomarker for colorectal cancer. We compared the secreted glycoprotein profiles (glyco-secretomes) enriched from the colon adenocarcinoma cell line HCT-116 and its metastatic derivative, E1, and observed that laminin β-1 (LAMB1) was oversecreted in E1 cells. Read More

J Wound Care 2019 Apr;28(4):246-255

Consultant Clinical Microbiology and Infection Control, Consultant Infectious Diseases and Tropical Medicine, Department for Hospital Epidemiology and Infection Control, Medical University of Vienna, Austria.

Objective: Due to classification of the agent polihexanide (PHMB) in category 2 'may cause cancer' by the Committee for Risk Assessment of the European Chemicals Agency in 2011, the users of wound antiseptics may be highly confused. In 2017, this statement was updated, defining PHMB up to 0.1% as a preservative safe in all cosmetic products. Read More

Cytotechnology 2019 Apr 9. Epub 2019 Apr 9.

Faculty of Science, Department of Biology, Ege University, Bornova, Izmir, 35100, Turkey.

The aim of this study was to reveal the biological activities and in vivo toxicity profiles of n-hexane, chloroform and methanol extracts of brown algae Halopteris scoparia L. Sauvageau. In this study, extracts were tested for their phytochemical contents and antioxidant activities. Read More

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India.

BMC Med Genet 2019 Apr 9;20(Suppl 1):52. Epub 2019 Apr 9.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Background: CpG island methylator phenotype (CIMP) is found in 15-20% of malignant colorectal tumors and is characterized by strong CpG hypermethylation over the genome. The molecular mechanisms of this phenomenon are not still fully understood. The development of CIMP is followed by global gene expression alterations and metabolic changes. Read More

Mod Pathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

DNA mismatch repair protein deficient colon cancer frequently displays reduced CDX2 expression, and recent literature has suggested that negative CDX2 expression is a poor prognostic biomarker in colon cancer. We have recently demonstrated that SATB2 is an immunohistochemical marker that is complementary to CDX2. Using a tissue microarray approach, we evaluated SATB2 and CDX2 immunohistochemical expression in 514 patients with colonic adenocarcinoma including 146 with mismatch repair protein deficient tumors and correlated expression with histopathologic variables, molecular alterations, and survival. Read More

Cells 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Antibodies blocking the programmed death-ligand 1 (PD-L1) have shown impressive and durable responses in clinical studies. However, this type of immunotherapy is only effective in a subset of patients and not sufficient for rejection of all tumor types. In this study, we explored in two mouse tumor models whether the antitumor effect could be enhanced by the combined blockade of PD-L1 and transforming growth factor-β (TGF-β), a potent immunosuppressive cytokine. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):276-281

Department of Pathology, Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China.

To investigate the correlation between poorly differentiated clusters (PDCs) in colorectal adenocarcinomas with clinicopathological parameters and its clinicopathological significance. One hundred and eighty-three colorectal adenocarcinomas resected by radical proctocolecomy were collected at Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, from January to December 2017. There were 122 male and 61 female patients with age ranging from 42 to 89 years (mean of 68 years). Read More

Anticancer Res 2019 Apr;39(4):1705-1710

University College London Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, Royal Free Campus, London, U.K.

Background/aim: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its expression has been demonstrated in malignancies including prostate cancer.

Materials And Methods: Near-infrared-emitting gold nanoparticles (AuNPs) were synthesized and conjugated to MGF. Read More

Int J Surg Case Rep 2019 Mar 21;57:118-121. Epub 2019 Mar 21.

Department of Surgery, University of Modena and Reggio Emilia - Policlinico of Modena, Via del Pozzo, 71, 41100 Modena, Italy. Electronic address:

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is nowadays a feasible and effective treatment for peritoneal metastasis. We present a case of a 14 years old child with peritoneal metastasis from recurrent colorectal cancer.

Presentation Of Case: Colonoscopy and CT-scan were performed leading to the diagnosis of a stenosing adenocarcinoma of the right colon in 2015. Read More

Indian J Surg Oncol 2019 Mar 12;10(1):37-39. Epub 2018 May 12.

Department of Surgical Oncology, JIPMER, Puducherry, Puducherry, India.

Although port site implants have been described after laparoscopic resection for gastrointestinal malignancies, drain site metastasis in solid intra-abdominal tumor after open resection is a rare phenomenon. Only few cases have been reported in literature describing drain site metastasis after open resection for carcinoma in the colon, stomach, cervix etc. Isolated drain site metastasis is even rare. Read More

J Pathol 2019 Apr 3. Epub 2019 Apr 3.

Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α) can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-RING E3 Ligases (CRLs) are emerging as master regulators controlling tumorigenesis. Read More

J Muscle Res Cell Motil 2019 Apr 3. Epub 2019 Apr 3.

Department of Physical Therapy, University of Florida, 1275 Center Drive, Gainesville, FL, 32610, USA.

The present study aimed to determine the impact of colon 26 adenocarcinoma (C26)-induced cancer cachexia on skeletal muscle mitochondrial respiration and content. Twelve male CD2F1 mice were injected with C26-cells (tumor bearing (TB) group), whereas 12 age-matched mice received PBS vehicle injection (non-tumor bearing (N-TB) group). Mitochondrial respiration was studied in saponin-permeabilized soleus myofibers. Read More

J Comput Biol 2019 Apr 3. Epub 2019 Apr 3.

4 Health Intelligence Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Human leukocyte antigen (HLA) genes provide useful information on the relationship between cancer and the immune system. Despite the ease of obtaining these data through next-generation sequencing methods, interpretation of these relationships remains challenging owing to the complexity of HLA genes. To resolve this issue, we developed a Bayesian method, ALPHLARD-NT, to identify HLA germline and somatic mutations as well as HLA genotypes from whole-exome sequencing (WES) and whole-genome sequencing (WGS) data. Read More

J BUON 2019 Jan-Feb;24(1):106-115

Department of Anesthesia and Intensive Care, Ion Chiricuta Clinical Research Center, Cluj-Napoca, Romania.

Purpose: Certain anesthetic interventions may influence the postoperative outcome in surgical cancer patients. Our study investigated the antiproliferative effects of propofol and lidocaine in two colon cancer cells lines, fibroblasts and in co-cultures.

Methods: The antiproliferative effects of concentrations of propofol and lidocaine were assessed in HCT-116 and RKO cell lines, in fibroblasts (CCD-18Co) and in co-culture system. Read More

Abdom Radiol (NY) 2019 Apr 2. Epub 2019 Apr 2.

Department of Diagnostic Radiology, Abdominal Division, Mayo Clinic Hospital, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose: Transformation of benign endometriosis to endometriosis-associated ovarian carcinoma (EAOC) is rare; however, women with endometriosis are four times more likely to develop EAOC which can present 20 years earlier than de novo ovarian cancer. Presenting symptoms are often vague and the radiologist's role in recognizing EAOC is critical for early detection and treatment. Histopathologic evaluation remains the mainstay for definitive diagnosis. Read More

Mil Med 2019 Apr 3. Epub 2019 Apr 3.

Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, 11300 Rockville Pike, Suite 1120, Rockville, MD 20852.

Introduction: Cancer is one of the leading causes of morbidity and mortality in the USA, contributing largely to US healthcare spending. Provision of services (direct or purchased) and insurance benefit type may impact cost for cancer care. As a common cause of cancer in both men and women, we aim to compare colon cancer treatment costs between insurance benefit types and care sources in the US Military Health System (MHS) to better understand whether and to what extent these system factors impact cancer care costs. Read More

World J Surg Oncol 2019 Apr 2;17(1):62. Epub 2019 Apr 2.

Department of Surgery, Roskilde Hospital, University of Copenhagen, Sygehusvej 10, 4000, Roskilde, Denmark.

Background: It has been suggested that apart from tumour and nodal status, a range of patient-related and histopathological factors including lymph node yield and tumour location seems to have prognostic implications in stage I-III colon cancer. We analysed the prognostic implication of lymph node yield and tumour subsite in stage I-III colon cancer.

Methods: Data on patients with stage I to III adenocarcinoma of the colon and treated by curative resection in the period from 2003 to 2011 were extracted from the Danish Colorectal Cancer Group database, merged with information from the Danish National Patient Register and analysed. Read More

Cureus 2019 Jan 23;11(1):e3942. Epub 2019 Jan 23.

Internal Medicine, Larkin Community Hospital, South Miami, USA.

Mixed adenoneuroendocrine carcinoma (MANEC) is an uncommon neoplasm with uncertain pathophysiology. In order to be classified as MANEC, the tumor must contain at least 30% neuroendocrine cells and 30% adenocarcinoma. The standardization of MANEC treatment has historically been difficult due to the lack of diagnostic histological classification. Read More

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Urology, Derby Teaching Hospitals NHS Foundation Trust, Derby, UK.

An 80-year-old man with history of prostate cancer successfully treated with brachytherapy was initially thought to have Fournier's gangrene until imaging detected a rectoprostatic fistula. Although this is known to be a rare complication of prostate brachytherapy, in this case the aetiology was a new primary rectal adenocarcinoma. It was not possible to catheterise per urethra owing to the fistula, so he was fitted with suprapubic catheter, and underwent palliative loop colostomy. Read More

Radiother Oncol 2019 Apr 16;133:50-53. Epub 2019 Jan 16.

Department of Radiation Oncology, Virginia Commonwealth University Health, United States.

Purpose: While there is no level 1 evidence supporting the use of adjuvant radiotherapy (RT) for non-rectal colon cancer in the modern chemotherapy era, there are studies that suggest a local control benefit. This treatment modality is not part of standard treatment recommendations, and we hypothesized that adjuvant RT provides a benefit in locally advanced disease. Due to the limited number who receive post-operative RT, a national database was searched to provide sufficient power. Read More

Molecules 2019 Mar 25;24(6). Epub 2019 Mar 25.

Pharmaceutical Chemistry Department, Faculty of Pharmacy Ain Shams University, Abbassia, Cairo 11566, Egypt.

The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, HepG2, liver hepatocellular carcinoma and MCF-7, human breast adenocarcinoma cell line), in addition to VEGFR-2 enzyme inhibition activity. Compounds , , , and exhibited promising activity against the tested cell lines and weak activity against VEGFR-2. Read More

Future Oncol 2019 Apr 1;15(10):1085-1095. Epub 2019 Apr 1.

Department of Gastrointestinal Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, UESTC, Chengdu, 610041, PR China.

Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately.

Patients & Methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis.

Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. Read More

J Gastroenterol Hepatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Background And Aims: Population-based studies on post-colonoscopy colorectal cancer (CRC) from Asia are sparse. We aimed to determine the characteristics and predictive factors and survival of post-colonoscopy CRC in Hong Kong.

Methods: This is a territory-wide retrospective cohort study. Read More

Asian J Endosc Surg 2019 Mar 31. Epub 2019 Mar 31.

Division of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.

We present a case of rectal cancer with rare variations of the left renal vessels. A man in his 60s underwent endoscopic mucosal resection for an Ip-type lesion in the upper rectum. Histologically, the lesion was a well-differentiated adenocarcinoma that had invaded the deep submucosal layer. Read More

Eur J Case Rep Intern Med 2019 11;6(2):001033. Epub 2019 Feb 11.

Internal Medicine Department, Egas Moniz Hospital, Lisbon, Portugal.

Malignant pericardial effusion is common, being reported in 5-15% of all cancer patients. It most commonly arises from metastasis of lymphomas and of tumours of the lung, breast and, infrequently, the gastrointestinal tract. We describe the case of a 76-year-old woman who presented to the emergency room with cervical adenopathies and clinical signs of acute heart failure. Read More

Front Genet 2019 15;10:213. Epub 2019 Mar 15.

Basic Experimental of Natural Science, University of Science and Technology Beijing, Beijing, China.

Colorectal cancer is the third most common cancer worldwide with abysmal survival, thus requiring novel therapy strategies. Numerous studies have frequently observed infiltrating bacteria within the primary tumor tissues derived from patients. These studies have implicated the relative abundance of these bacteria as a contributing factor in tumor progression. Read More

Biol Pharm Bull 2019 ;42(4):638-644

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University.

Oxaliplatin has been used as a first choice for colorectal, gastric and pancreatic cancer, but it induces peripheral neuropathies. Dimethyl fumarate (DMF) is an oral drug for multiple sclerosis with neuroprotective effects on oxidative stress. Using both in vivo and in vitro models, we investigated the effects of DMF on oxaliplatin-induced peripheral neuropathy and other side effects, as well as on the anti-tumor activity of oxaliplatin. Read More

Nutrients 2019 Mar 28;11(4). Epub 2019 Mar 28.

Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université Oran1, 31000 Oran, Algeria.

The application of plant extracts for therapeutic purposes has been used in traditional medicine since the plants are a source of a great variety of chemical compounds that possess biological activity. Actually, the effect of these extracts on diseases such as cancer is being widely studied. Colorectal adenocarcinoma is one of the main causes of cancer related to death and the second most prevalent carcinoma in Western countries. Read More

Int J Cell Biol 2019 21;2019:3059687. Epub 2019 Feb 21.

Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin, 22200 Besut, Terengganu Darul Iman, Malaysia.

Combination of natural products with chemodrugs is becoming a trend in discovering new therapeutics approach for enhancing the cancer treatment process. In the present study, we aimed to investigate the cytotoxic and apoptosis induction of Gelam honey (GH) combined with or without 5-Fluorouracil (5-FU) on HT-29 cells. The cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to assess cytotoxicity. Read More

Cancer Commun (Lond) 2019 Mar 29;39(1):13. Epub 2019 Mar 29.

Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, P. R. China.

Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC) characterized by the presence of abundant extracellular mucin which accounts for at least 50% of the tumor volume. Mucinous colorectal adenocarcinoma is found in 10%-20% of CRC patients and occurs more commonly in female and younger patients. Moreover, mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage. Read More

ERJ Open Res 2019 Feb 25;5(1). Epub 2019 Mar 25.

Dept of Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Objectives: Molecular profiling of tumours has become the mainstay of diagnostics for metastasised solid malignancies and guides personalised treatment, especially in nonsmall cell lung cancer (NSCLC). In current practice, it is often challenging to obtain sufficient tumour material for reliable molecular analysis. Cell-free DNA (cfDNA) in blood or other bio-sources could present an alternative approach to obtain genetic information from the tumour. Read More

World J Gastrointest Oncol 2019 Mar;11(3):195-207

Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

Background: There is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin (Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern that are distinct from B cell-derived Ig. Especially, the cancer-derived Ig plays important roles in cancer initiation, progression, and metastasis. However, it still remains unclear if the colon cancer-derived Ig can display unique V(D)J pattern and sequencing, which can be used as novel target for colon cancer therapy. Read More

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Shizuoka Cancer Center, Division of Pathology, Japan.

A 60-year-old man was referred for the investigation of giant gastric folds, life-threatening anemia and hypoproteinemia. A combination of multiple endoscopic procedures derived a clinical diagnosis of protein-losing gastropathy with two gastric adenomas. After two months of alimentary therapy, the patient received total gastrectomy and fully recovered. Read More

Int J Colorectal Dis 2019 May 26;34(5):899-904. Epub 2019 Mar 26.

Division of Colon and Rectal Surgery, Assistant Professor of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC).

Methods: Retrospective cohort study of all consecutive women of childbearing age (18-45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Read More

Gan To Kagaku Ryoho 2019 Mar;46(3):475-477

Dept. of Surgery, Kure Kyosai Hospital.

We report a case of locally advanced rectal cancer presenting with perforation that was successfully resected after preoperative chemotherapy. A 66-year-old woman visited our emergency room complaining of lower abdominal pain. Abdominal CT showed a rectal tumor with fluid collection and free air in the pelvis. Read More

Surg Case Rep 2019 Mar 25;5(1):45. Epub 2019 Mar 25.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin- Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Intestinal malrotation, which arises from incomplete rotation of the embryonic midgut, is one of the congenital anomalies usually diagnosed in infancy. On the other hand, intestinal malrotation detected in asymptomatic adults is very rare. It is frequently diagnosed incidentally during abdominal surgery. Read More

Case Rep Oncol Med 2019 17;2019:4767019. Epub 2019 Feb 17.

Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Greece.

This is a case of a patient who presented to the emergency department with acute abdominal pain due to bowel obstruction. An extended right hemicolectomy with ileosigmoid anastomosis due to an obstructing mass on the splenic flexure was urgently performed. During operation, liver and peritoneal lesions were detected and samples were also sent for histological analysis. Read More

Cancer Prev Res (Phila) 2019 Mar 25. Epub 2019 Mar 25.

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

Physical activity has been associated with a lower risk of colorectal cancer. However, data is lacking on whether the association is consistent between sexes and across different races/ethnicities and anatomic subsites of tumors. We analyzed data from the Multiethnic Cohort in Hawaii and California, consisting of mostly African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites ages 45-75 years at recruitment. Read More

J Clin Med 2019 Mar 20;8(3). Epub 2019 Mar 20.

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

The metabolites produced by the host's gut microbiota have an important role in the maintenance of intestinal homeostasis, but can also act as toxins and induce DNA damage in colorectal epithelial cells increasing the colorectal cancer (CRC) chance. In this scenario, the impact of some of the components of the natural human gastrointestinal microbiota, such as (), at the onset of CRC progression remains controversial. Since under dysbiotic conditions it could turn into a pathogen, the aim of this study was to compare the effect of ' strains (isolated from CRC patients and healthy subjects' stools) on the proliferation of different colorectal cells lines. Read More

J Gastrointest Cancer 2019 Mar 21. Epub 2019 Mar 21.

Department of Surgery N1, Yerevan State Medical University after M.Heratsi, Yerevan, Armenia.

Purpose: This study reports single-surgeon experience with extended gastrectomy including en-bloc resection of adjacent organs/structures for T4b stage gastric adenocarcinoma. Time-related changes in patient selection criteria and outcomes were also analyzed.

Methods: All consecutive gastrectomies for adenocarcinoma performed between May 2004 and December 2017 were extracted from prospectively collected database to study surgical and oncologic results. Read More

J Agric Food Chem 2019 Apr 28;67(14):3919-3931. Epub 2019 Mar 28.

Department of Life Sciences , University of Modena and Reggio Emilia , Via Amendola 2 , 42100 Reggio Emilia , Italy.

In this study, we investigated the antiproliferative activity and the stability and metabolic fate of the main dietary hydroxycinnamates, using two colonic adenocarcinoma cell models (Caco-2 and SW480). Dihydrocaffeic and dihydroferulic acids were the most effective against cell proliferation in both cell lines with IC values of 71.7 ± 1. Read More