200,649 results match your criteria Colon Cancer Adenocarcinoma


Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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December 2018

A novel prognostic prediction model for recurrence in patients with stage II colon cancer after curative resection.

Mol Clin Oncol 2018 Dec 4;9(6):697-701. Epub 2018 Oct 4.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

The present study aimed to clarify the risk factors for recurrence of stage II colon cancer in patients and to determine possible treatment options for postoperative adjuvant chemotherapy. A prediction model for recurrence in patients with stage II colon cancer after curative surgical resection was developed. The present study retrospectively investigated 436 patients who underwent curative resection for stage II colon cancer at Osaka International Cancer Institute and Yao Municipal Hospital between 2004 and 2012. Read More

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December 2018

Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review.

Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More

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December 2018

Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases.

Mol Clin Oncol 2018 Dec 5;9(6):587-591. Epub 2018 Oct 5.

Department of Surgical Oncology, Gifu University School of Medicine, Gifu, Gifu 501-1194, Japan.

Pathological complete response is achievable with mFOLFOX6 plus cetuximab therapy for unresectable colorectal cancer with multiple paraaortic lymph node metastases (mCRC) despite right-sided colonic origin. A 62-year-old woman with synchronous paraaortic lymph node metastases of transverse colon cancer was treated with mFOLFOX6 plus cetuximab as first-line therapy. The tumor size was markedly decreased following 6 courses of chemotherapy, and all lymph node metastases had disappeared. Read More

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December 2018

Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood.

Oncotarget 2018 Nov 16;9(90):36166-36184. Epub 2018 Nov 16.

Bioscience, Respiratory, Inflammation and Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden.

As we learn more about how immune responses occur , it is becoming clear that each organ/tissue is characterized with its own anatomy and microenvironment which may affect and even determine the outcome of the immune responses. With emerging data from animal studies showing that regulatory T cells infiltrating non-lymphoid tissues exhibit unique phenotypes and transcriptional signatures and display functions beyond their well-established suppressive roles, there is an urgent need to explore the function of tissue Treg cells in humans. Here we characterized the transcriptome of Treg residing at the human mucosal tissue obtained from the normal area of cancer resections and their peripheral blood counterparts, identifying human lung and colon tissue Treg signature genes and their upstream regulators. Read More

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November 2018

Inhibition of breast cancer metastasis to the lungs with UBS109.

Oncotarget 2018 Nov 16;9(90):36102-36109. Epub 2018 Nov 16.

Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.

Synthetic monocarbonyl analogs of curcumin (MACs) are cytotoxic against several cancers including head and neck cancer, pancreatic cancer, colon cancer, and breast cancer. Mechanisms of action include depolarization of the mitochondrial membrane potential and inhibition of NF-κB, leading to apoptosis. We previously demonstrated that UBS109 (MAC), has preventive effects on bone loss induced by breast cancer cell lines. Read More

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November 2018

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.

Oncol Lett 2018 Dec 28;16(6):7264-7270. Epub 2018 Sep 28.

Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.

With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. Read More

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December 2018

Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells.

Oncol Lett 2018 Dec 28;16(6):7175-7179. Epub 2018 Sep 28.

Department of Gastrointestinal Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

This study investigated the role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Fifty-five patients with colon cancer who were treated in China-Japan Union Hospital of Jilin University from March 2014 to March 2015 were enrolled into this study. Their cancer and corresponding paracancerous tissues were collected and the expression levels of miR-214 were determined by RT-qPCR. Read More

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December 2018

Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128.

Exp Ther Med 2018 Dec 28;16(6):4824-4830. Epub 2018 Sep 28.

Department of Nursing, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan 423000, P.R. China.

A previous study implied that long intergenic non-coding RNA 1410 (LINC01410) promotes angiogenesis and metastasis of gastric cancer. However, the role of LINC01410 in colon cancer (CC) has remained elusive. In the present study, LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. Read More

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December 2018

Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Exp Ther Med 2018 Dec 19;16(6):4445-4456. Epub 2018 Sep 19.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. Read More

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December 2018

Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.

Pathologica 2018 Sep;110(2):111-115

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, Policlinico Universitario-Vittorio Emanuele, University of Catania, Italy.

Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. Read More

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September 2018

Internal Hernia Associated with Colostomy After Laparoscopic Surgery for Rectal Malignancy: A Report of 3 Thought-Provoking Cases.

Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More

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December 2018

Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival.

Methods: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. Read More

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December 2018

Central 5-hydroxytryptamine (5-HT) mediates colonic motility by hypothalamus oxytocin-colonic oxytocin receptor pathway.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Department of Physiology and Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address:

Gut-derived 5-hydroxytryptamine (5-HT) is well known for its role in mediating colonic motility function. However, it is not very clear whether brain-derived 5-HT is involved in the regulation of colonic motility. In this study, we used central 5-HT knockout (KO) mice to investigate whether brain-derived 5-HT mediates colonic motility, and if so, whether it involves oxytocin (OT) production in the hypothalamus and OT receptor in the colon. Read More

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December 2018

Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium.

Comp Med 2018 Dec 13. Epub 2018 Dec 13.

Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycinand metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function,cytokine and chemokine profiles, and neutrophil migration in colon tissue. Azithromycin treatment significantly reduced theseverity of colitis, as assessed through body weight change, water consumption, macroscopic lesions, and animal behaviors(activity level, climbing, and grooming), but did not alter food consumption or feeding behavior. Read More

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December 2018

Survival and quality of life after surgery for colorectal cancer in the elderly: a comparative study.

Rev Esp Enferm Dig 2018 Dec 14;111. Epub 2018 Dec 14.

Hospital Germans Trias i Pujol.

Background: the aim of this study was to analyze the clinical results of the multidisciplinary management of elderly patients with colorectal cancer in a single center and to describe postoperative quality of life.

Methods: a comparative study was designed to compare the results and quality of life of patients treated in our center for colon cancer, aged from 80 to 84 years (study group) compared to a control group (aged form 75 to 79 years of age). Morbidity, mortality, oncological results and quality of life were analyzed. Read More

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December 2018

Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.

Authors:
Carolyn M Klinge

Noncoding RNA 2018 Dec 12;4(4). Epub 2018 Dec 12.

Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40292, USA.

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes, including levels and activity of estrogen receptor α (ERα), proliferation, invasion, migration, apoptosis, and stemness. In addition, ncRNAs can be packaged into exosomes to provide intercellular communication by the transmission of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) to cells locally or systemically. Read More

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December 2018

Gut Microbiota, Fusobacteria, and Colorectal Cancer.

Diseases 2018 Dec 11;6(4). Epub 2018 Dec 11.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

The gut microbiota has emerged as an environmental contributor to colorectal cancer (CRC) in both animal models and human studies. It is now generally accepted that bacteria are ubiquitous colonizers of all exposed human body surfaces, including the entire alimentary tract (5). Recently, the concept that a normal bacterial microbiota is essential for the development of inflammation-induced carcinoma has emerged from studies of well-known colonic bacterial microbiota. Read More

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December 2018

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive oxygen species (ROS) levels. Investigating the anti-cancer properties of novel 1,8-naphthalimide derivatives containing Rh(I) and Ru(II) -heterocyclic carbene (NHC) ligands, we observed a profound induction of ROS by the complexes, which is most likely generated from mitochondria (mtROS). Read More

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December 2018

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins.

Cells 2018 Dec 10;7(12). Epub 2018 Dec 10.

Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.

The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (HSP27) is a chaperone that interacts with many proteins. Read More

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December 2018

Flavonoids and Colorectal Cancer Prevention.

Antioxidants (Basel) 2018 Dec 10;7(12). Epub 2018 Dec 10.

Division of Hematology & Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Abor, MI 48109, USA.

Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related mortality. Prevention may, therefore, be a key strategy in reducing colorectal cancer deaths. Given reports of an inverse association between fruit and vegetable consumption with colorectal cancer risk, there has been significant interest in understanding the metabolism and bioactivity of flavonoids, which are highly abundant in fruits and vegetables and account for their pigmentation. Read More

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December 2018

Spatial-Temporal Analysis of PM and NO₂ Concentrations Collected Using Low-Cost Sensors in Peñuelas, Puerto Rico.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

Region 2, U.S. Environmental Protection Agency, Edison, NJ 08837-3679, USA.

The U.S. Environmental Protection Agency (EPA) is involved in the discovery, evaluation, and application of low-cost air quality (AQ) sensors to support citizen scientists by directly engaging with them in the pursuit of community-based interests. Read More

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December 2018

Cardiac tamponade after radiofrequency ablation for hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Dec;97(49):e13532

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA. Read More

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December 2018

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon.

Eur Surg Res 2018 Dec 13;59(5-6):371-379. Epub 2018 Dec 13.

The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More

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December 2018

Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.

Int Immunopharmacol 2018 Dec 10;67:129-137. Epub 2018 Dec 10.

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (Jiang Su Province Hospital of Traditional Chinese Medicine), Nanjing 210029, China. Electronic address:

Gallic acid (GA), as an active component, has been found in many fruits and plants, and it exhibits potential protective effects, such as anti-inflammatory, antioxidant, antiviral and anticancer. However, the effects of GA on ulcerative colitis (UC) remain unknown. The purpose of this study was to investigate the effects of GA on IL-1β-induced HIEC-6 cells and TNBS-induced UC in mice. Read More

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December 2018

Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program.

Eur J Cancer 2018 Dec 10;107:53-59. Epub 2018 Dec 10.

Epidemiology and Evaluation Department, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; REDISSEC (Health Services Research on Chronic Patients Network), Madrid, Spain.

Introduction: Increased values in the fecal immunochemical test (FIT) are correlated with increasingly severe colorectal neoplasia, but little attention has been given to FIT values below the cut-off point (negative FIT, nFIT). We analysed the relationship between the concentrations of two consecutive nFIT and the risk of following screen-detected advanced neoplasia and interval cancer (IC) in a population-based colorectal cancer screening program.

Methods: FIT results were categorised into non-detectable nFIT (0-3. Read More

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December 2018

Composition, antioxidant capacity and cytotoxic activity of Eugenia uniflora L. chemotype-oils from the Amazon.

J Ethnopharmacol 2018 Dec 10. Epub 2018 Dec 10.

Programa de Pós-Graduação em Química, Universidade Federal do Pará, 66075-110 Belém, PA, Brazil. Electronic address:

Ethnopharmacological Relevance: Oils and extracts of Eugenia uniflora have been reported as antimicrobial, antifungal, antinociceptive, antiprotozoal, antioxidant and cytotoxic.

Aim Of The Study: The oils of five specimens (E1 to E5) that occur in the Brazilian Amazon were extracted, analyzed for their chemical composition, and submitted to antioxidant and cytotoxic assays.

Material And Methods: Oils were hydrodistilled, analyzed by GC and GC-MS, and submitted to PCA and HCA analyses. Read More

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December 2018

Practice Patterns for Older Adult Patients With Advanced Cancer: Physician Office Versus Hospital Outpatient Setting.

J Oncol Pract 2018 Dec 13:JOP1800315. Epub 2018 Dec 13.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose:: A shift in outpatient oncology care from the physician's office to hospital outpatient settings has generated interest in the effect of practice setting on outcomes. Our objective was to examine whether medical oncologists' prescribing of drugs and services for older adult patients with advanced cancer is used more in physicians' offices compared with hospital outpatient departments.

Methods:: This was a retrospective comparative study. Read More

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December 2018

Mid-arm muscle circumference: A significant factor of all-cause and cancer mortalities in individuals with elevated platelet-to-lymphocyte ratio.

PLoS One 2018 13;13(12):e0208750. Epub 2018 Dec 13.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Platelet-to-lymphocyte ratio (PLR) is an inflammatory maker, and high PLR is associated with mortality in several diseases. The predictors of mortality in individuals with high PLR is still lacking. Our aims were to assess if mid-arm muscle circumference (MAMC) can predict all-cause mortality, cancer mortality, and cardiovascular mortality in individuals with high PLR. Read More

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December 2018

Medium- to Long-term Follow-up of Obstetric Anal Sphincter Injury.

Dis Colon Rectum 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics, Gynaecology & Neonatology, Sydney Medical School Nepean, The University of Sydney, Kingswood, NSW, Australia.

Background: Obstetric anal sphincter injury is the primary modifiable risk factor for anal incontinence in women. Currently, endoanal ultrasound is most commonly used to detect residual anal sphincter defects after childbirth. Translabial ultrasound has recently been introduced as a noninvasive alternative. Read More

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December 2018

Prolonged Postoperative Ileus Significantly Increases the Cost of Inpatient Stay for Patients Undergoing Elective Colorectal Surgery: Results of a Multivariate Analysis of Prospective Data at a Single Institution.

Dis Colon Rectum 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, University of Auckland, Auckland, New Zealand.

Background: Prolonged postoperative ileus is a common major complication after abdominal surgery. Retrospective data suggest that ileus doubles the cost of inpatient stay. However, current economic impact data are based on retrospective studies that rely on clinical coding to diagnose ileus. Read More

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December 2018

is a microRNA safeguard for -induced inflammatory colon oncogenesis.

Elife 2018 Dec 13;7. Epub 2018 Dec 13.

Center for Genomics and Computational Biology, Duke University, Durham, United States.

Inflammation often induces regeneration to repair the tissue damage. However, chronic inflammation can transform temporary hyperplasia into a fertile ground for tumorigenesis. Here, we demonstrate that the microRNA acts as a central safeguard to protect the inflammatory stem cell niche and reparative regeneration. Read More

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December 2018

Standardize the Surgical Technique and Clarify the Relevant Anatomic Concept for Complete Mobilization of Colonic Splenic Flexure Using da Vinci Xi Robotic System.

World J Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, Taiwan, ROC.

Background: The present study is to set up a standardized approach for complete mobilization of colonic splenic flexure using da Vinci Xi robotic system, based on clarification of the mesenteric structures of distal transverse colon.

Methods: The surgical outcomes and relevant anatomic structures of 104 consecutive patients undergoing robotic resection of primary colorectal cancer with the intent of complete mobilization of colonic splenic flexure using da Vinci Xi robotic system were retrospectively reviewed.

Results: Complete mobilization of colonic splenic flexure can be efficiently performed by the Xi robotic system, as demonstrated by short operation time, minimal intra-operative blood loss, and few surgical complications. Read More

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December 2018

Risk of postoperative morbidity in patients having bowel resection for colonic Crohn's disease.

Tech Coloproctol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Ålborg University Hospital, Ålborg, Denmark.

Background: The aim of the present multicenter study was to analyze the incidence and risk factors associated with postoperative morbidity in patients who had colorectal resection for colonic Crohn's disease.

Methods: Consecutive patients undergoing colorectal resection for colonic Crohn's disease at seven surgical units in 1992-2017 were included. Exclusion criteria were: proctectomy for perianal disease, surgery for cancer, previous colectomies, surgery before 1998. Read More

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December 2018

Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization.

Methods Mol Biol 2019 ;1907:91-102

Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

The tissue engineering method of decellularization and recellularization has been successfully used in a variety of regenerative medicine applications. The protocols used to de/recellularize various organs and tissues are largely different. Here we describe a method to effectively engineer a bioartificial colon by completely removing original cells from human intestinal tissues followed by repopulating the acellular tissue matrix with cell cultures. Read More

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January 2019

Isolated thoracic perfusion in lung metastases from breast cancer: a retrospective observational study.

Updates Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

The median overall survival of metastatic breast cancer (MBC) patients is still approximately 2 years. This is even lower in triple-negative breast cancer (TNBC) patients with concomitant lung metastases. These patients are often not suitable for surgery and not responsive to systemic chemotherapy. Read More

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December 2018

Oncolytic properties of non-vaccinia poxviruses.

Oncotarget 2018 Nov 13;9(89):35891-35906. Epub 2018 Nov 13.

Transgene SA, Illkirch-Graffenstaden 67405, France.

Vaccinia virus, a member of the family, has been extensively used as an oncolytic agent and has entered late stage clinical development. In this study, we evaluated the potential oncolytic properties of other members of the family. Numerous tumor cell lines were infected with ten non-vaccinia poxviruses to identify which virus displayed the most potential as an oncolytic agent. Read More

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November 2018

Rhein enhances the cytotoxicity of effector lymphocytes in colon cancer under hypoxic conditions.

Exp Ther Med 2018 Dec 12;16(6):5350-5358. Epub 2018 Oct 12.

Tianjin Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

The immunosuppressive tumor microenvironment limits the application of adoptive immunotherapy for solid tumors. Hypoxia is closely associated with the formation of the immunosuppressive tumor microenvironment. Hypoxia-inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional activator that drives the transcription of several immunosuppressive molecules. Read More

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December 2018

Dynamics of Colon Monocyte and Macrophage Activation During Colitis.

Front Immunol 2018 27;9:2764. Epub 2018 Nov 27.

Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Macrophages are pivotal in coordinating a range of important processes in the intestines, including controlling intracellular infections and limiting damaging inflammation against the microbiota. However, it is not clear how gut macrophages, relative to recruited blood monocytes and other myeloid cells, contribute to the intestinal inflammatory milieu, nor how macrophages and their monocyte precursors mediate recruitment of other immune cells to the inflamed intestine. Myeloid cell populations isolated from colonic inflammatory bowel disease (IBD) or murine dextran sulphate sodium (DSS) induced colitis were assessed using flow cytometry and compared to healthy controls. Read More

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November 2018

Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli.

Sci Rep 2018 Dec 12;8(1):17780. Epub 2018 Dec 12.

Department of Molecular Biology and The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-90187, Umeå, Sweden.

Cytotoxic necrotizing factor 1 (CNF1), a protein toxin produced by extraintestinal pathogenic Escherichia coli, activates the Rho-family small GTPases in eukaryotic cell, thereby perturbing multiple cellular functions. Increasing epidemiological evidence suggests a link between CNF1 and human inflammatory bowel disease and colorectal cancer. At the cellular level, CNF1 has been hypothesized to reprogram cell fate towards survival due to the role in perturbing cell cycle and apoptosis. Read More

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December 2018

Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis.

Proc Natl Acad Sci U S A 2018 Dec 12. Epub 2018 Dec 12.

Shanghai Institute of Immunology, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;

Dendritic cells (DCs) play pivotal roles in maintaining intestinal homeostasis, but how the DCs regulate diverse immune networks on homeostasis breakdown remains largely unknown. Here, we report that, in response to epithelial barrier disruption, colonic DCs regulate the differentiation of type 1 regulatory T (Tr1) cells through p38α-dependent IL-27 production to initiate an effective immune response. Deletion of p38α in DCs, but not in T cells, led to increased Tr1 and protected mice from dextran sodium sulfate-induced acute colitis and chronic colitis-associated colorectal cancer. Read More

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December 2018

The Epstein-Barr virus induces the expression of the LPAM-1 integrin in B-cells and .

J Virol 2018 Dec 12. Epub 2018 Dec 12.

German Cancer Research Centre (DKFZ) Unit F100, Heidelberg, Germany

The Epstein-Barr virus (EBV) infects the oropharynx but surprisingly frequently induces B-cell proliferations in the gut of immunosuppressed individuals. We found that EBV infection induces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. Read More

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December 2018

Alberta Family Physician Electronic Endoscopy study: Quality of 1769 colonoscopies performed by rural Canadian family physicians.

Can Fam Physician 2018 Dec;64(12):e553-e560

Professor and Chair in the Department of Family Medicine at the University of Alberta.

Objective: To determine whether rural FP colonoscopists in Alberta are achieving benchmarks in colonoscopy quality.

Design: Prospective, multicentre observational study.

Setting: Alberta. Read More

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December 2018

Gastrocolocutaneous fistula: An undetected complication of colon transfixation during percutaneous endoscopic gastrostomy.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterology, GENE - Artificial Feeding Team, Hospital Garcia de Orta, Almada, Portugal ; CiiEM, Centro de investigação interdisciplinar Egas Moniz, Monte da Caparica, Portugal.

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December 2018

Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis.

J Transl Med 2018 Dec 12;16(1):350. Epub 2018 Dec 12.

Scientific Direction, Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, Naples, Italy.

Background: Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understanding of the molecular mechanisms that contribute to the pathogenesis in different location of colon is still unclear. Probably an important role could be played by genes that control the spatial-temporal development of bodily structures, such as HOX genes. Read More

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December 2018

Remodeling of Rectal Innervation After Pullthrough Surgery for Hirschsprung Disease: Relevance to Criteria for the Determination of Retained Transition Zone.

Pediatr Dev Pathol 2018 Dec 12:1093526618817658. Epub 2018 Dec 12.

7 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: After pullthrough surgery for Hirschsprung disease (HSCR), Glut1-positive submucosal nerve hypertrophy is used to diagnose retained transition zone in the neorectum. We hypothesized that pelvic nerves, severed during pullthrough surgery, sprout into the neorectum to mimic transition zone.

Methods: The density (nerves/100x field) and maximum diameter of Glut1-positive submucosal nerves were measured in biopsies and redo resections from 20 patients with post-pullthrough obstructive symptoms. Read More

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December 2018

Specific microbiota dynamically regulate the bidirectional gut-brain axis communications in mice fed meat protein diets.

J Agric Food Chem 2018 Dec 12. Epub 2018 Dec 12.

The purpose of this study was to characterize the dynamic changes of different protein diets to gut microbiota and explore the influence on communications between the gut and the brain. C57BL/6J mice were fed casein, soy protein and four kinds of processed meat proteins at a normal dose of 20% for 8 months. Bacteroidales S24-7 abundance increased from 4 to 8 months, whereas the abundances of six genera including Akkermansia decreased remarkably. Read More

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December 2018

SIRT3 Deficiency Promotes High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease In Correlation With Impaired Intestinal Permeability Through Gut Microbial Dysbiosis.

Mol Nutr Food Res 2018 Dec 7:e1800612. Epub 2018 Dec 7.

M. Chen, S. Hui, H. Lang, M. Zhou, Y. Zhang, C. Kang, X. Zeng, Q. Zhang, L. Yi, M. Mi, Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.

Scope: Sirtuin 3 (SIRT3) plays a protective role against non-alcoholic fatty liver disease (NAFLD) by improving hepatic mitochondrial dysfunction. Gut microbiota imbalance contributes to the pathogenesis of NAFLD, yet the underlying mechanism linking SIRT3 with gut microbiota in NAFLD progression remains obscure.

Methods And Results: Wild-type 129 mice and SIRT3 knockout (SIRT3KO) mice were under a chow diet or high-fat diet (HFD) treatment for 18-weeks. Read More

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December 2018

Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway.

J Cell Biochem 2018 Dec 7. Epub 2018 Dec 7.

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, SungKyunKwan University, Chunchun-Dong, Jangan-Gu, Suwon, Kyunggi-Do, Korea.

A water-soluble saponin, Esculentoside H (EsH), 3-O-(O-β-d-glucopyranosyl-(1→4)-β-d-xylopyranosyl)-28-β-d-glucopyranosylphytolaccagenin has been isolated and purified from the root extract of perennial plant Phytolacca esculenta. EsH is known to be an anticancer compound, having a capacity for TNF-α release. However, the effects of EsH on migration and growth in tumor cells have not yet been reported. Read More

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December 2018

5-Hydroxytryptamine (5-HT)-exacerbated DSS-induced colitis is associated with elevated NADPH oxidase expression in the colon.

J Cell Biochem 2018 Dec 7. Epub 2018 Dec 7.

Department of Gastroenterology and Hepatology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Aim: This study investigated the impact of 5-hydroxytryptamine (5-HT) on the expression of NOXs in dextran sulfate sodium (DSS)-induced colitis in mice.

Methods: C57BL/6J (B6) mice at 6 to 8 weeks of age were treated with 5-HT, DSS, or DSS + 5-HT. After 6-day treatment, the severity of colitis, infiltration of leukocytes, and messenger RNA (mRNA) and/or protein levels of Nox1, Nox2, Nox4, and Duox2 were analyzed in the colon by real-time quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), and Western blot analysis. Read More

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December 2018