22,364 results match your criteria Colon Adenocarcinoma


Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

EBioMedicine 2020 Jul 8;57:102860. Epub 2020 Jul 8.

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, Massachusetts, USA. Electronic address:

Background: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma.

Methods: Utilising 915 colon and rectal carcinomas in two U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2020.102860DOI Listing

Isothymusin, a potential inhibitor of cancer cell proliferation: An in silico and in vitro investigation.

Curr Top Med Chem 2020 Jul 9. Epub 2020 Jul 9.

Molecular Bioprospection Department of Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, Uttar Pradesh. India.

Background: Since centuries plant-based compounds are known for the treatment of cancer in both traditional and contemporary medicine. The problems like target non-specificity and toxicity are well-known regarding anticancer drugs. Therefore, target specific search of novel entities is constant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026620666200710103636DOI Listing

A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors.

Genomics 2020 Jul 6. Epub 2020 Jul 6.

Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China. Electronic address:

Although emerging cell- or animal-based evidence supports the relationship between SND1 and cancers, no pan-cancer analysis is available. We thus first explored the potential oncogenic roles of SND1 across thirty-three tumors based on the datasets of TCGA (The cancer genome atlas) and GEO (Gene expression omnibus). SND1 is highly expressed in most cancers, and distinct associations exist between SND1 expression and prognosis of tumor patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2020.06.044DOI Listing

Metastatic Gastric Signet Ring Cell Adenocarcinoma Presenting With Colonic Stenosis.

Cureus 2020 Jun 3;12(6):e8420. Epub 2020 Jun 3.

Gastroenterology, University Medical Centre Ljubljana, Ljubljana, SVN.

Metastases to the colon are rare and may mimic other diseases such as inflammatory bowel disease. This differential diagnosis is often overlooked by endoscopists which leads to unnecessary diagnostic delay or inappropriate treatment. We present a case of a 54-year-old woman who presented with ascites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336610PMC

Increased incidence of early onset colorectal adenocarcinoma is accompanied by an increased incidence of rectal neuroendocrine tumors.

Am J Cancer Res 2020 1;10(6):1888-1899. Epub 2020 Jun 1.

Department of Population Health and Disease Prevention, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, CA, USA.

Recent studies have reported an increasing incidence of early onset colorectal cancer (CRC). Few studies compared the changing incidence of CRC by the major histological type, adenocarcinoma and neuroendocrine tumors (NETs). Using data from the Surveillance, Epidemiology, and End Results Program (SEER), we identified CRC from 1992 to 2015 with site and histological codes. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339271PMC

Molecular docking and machine learning analysis of Abemaciclib in colon cancer.

BMC Mol Cell Biol 2020 Jul 8;21(1):52. Epub 2020 Jul 8.

Department of Computer Science and Information Technologies, Faculty of Computer Science, University of A Coruña, CITIC, Campus Elviña s/n, A Coruña, 15071, Spain.

Background: The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised opens the doors to the design and discovery of new specific treatments for each patient. In this context, this work offers new ways to reuse existing databases and work to create added value in research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12860-020-00295-wDOI Listing

Robotic right hemicolectomy with D3 lymphadenectomy, complete mesocolon excision (CME) and intracorporeal anastomosis.

Colorectal Dis 2020 Jul 8. Epub 2020 Jul 8.

Hospital Clinic, Barcelona, Spain.

Background: Complete mesocolic excision (CME) was first described in May 2009 by Werner Hohenberger and his colleagues (1). It arose from the concept of Total Mesorectal Excision illustrated by Heald (2), and consists of sharp dissection of the visceral fascial layer from the parietal one, complete mobilization of the mesocolon with an intact fascia and true central vascular ligation of the supplying arteries and draining veins at their origin. Current evidence suggests this technique is associated with better specimen quality, lower recurrence rates, higher disease-free survival, but also higher incidence of intraoperative injuries and surgical morbidity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/codi.15256DOI Listing

Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Shanghai Xuhui District Central Hospital & Zhongshan-xuhui Hospital, Zhongshan Hospital, Fudan University, Shanghai, China.

Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS-CoV-2, could indicate the susceptibility to SARS-CoV-2 infection, here we systematically dissected ACE2 expression using large-scale multi-omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS-CoV-2 infection for certain tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.15607DOI Listing

Survival impact of adjuvant chemotherapy in patients with Stage IIA colon cancer: analysis of the National Cancer Database.

Int J Cancer 2020 Jul 7. Epub 2020 Jul 7.

Colon and Rectal Surgery, Mayo Clinic, Rochester, MN.

Utility of adjuvant chemotherapy for stage II cancer is still a matter of debate. Clinical guidelines suggest adjuvant chemotherapy for stage II tumors with high-risk features, in particular T4 tumors. However, limited consensus exists regarding the importance of other high risk features (lymphovascular or perineural invasion, microsatellite instability). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.33203DOI Listing

High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.

Purinergic Signal 2020 Jul 8. Epub 2020 Jul 8.

Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Maternity and Child Health Hospital,, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear. Using the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, we found that the pyrimidine metabolism signaling pathway was significantly enriched in LUAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11302-020-09711-4DOI Listing

Direct evidence of active SARS-CoV-2 replication in the intestine.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Currently, there is no direct evidence to prove the active SARS-CoV-2 replication in the intestinal tract and relevant pathological changes in the colon and rectum. We investigated the presence of virions and pathological changes in surgical rectal tissues of a clinically confirmed COVID-19 patient with rectal adenocarcinoma.

Methods: Here, the clinical data were collected during hospitalization and follow-up of this patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa925DOI Listing

.

Authors:
Albert P Li

Drug Metab Dispos 2020 Jul 7. Epub 2020 Jul 7.

In Vitro ADMET Laboratories Inc., United States of America

Elements of key enteric drug metabolism and disposition pathways are reviewed to aid the assessment of the applicability of current cell-based enteric experimental systems for the evaluation of enteric metabolism and drug interaction potential. Enteric nuclear receptors include vitamin D receptor, constitutive androstane receptor, Pregnane X receptor, farnesoid X receptor, liver X receptor, aryl hydrocarbon receptor, and peroxisome proliferator-activated receptor. Enteric drug metabolizing enzyme pathways include both P450 and non-P450 drug metabolizing enzymes based on gene expression, proteomics, and activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.120.000053DOI Listing

Prevalence of Helicobacter pylori among Sudanese patients diagnosed with colon polyps and colon cancer using immunohistochemistry technique.

BMC Res Notes 2020 Jul 6;13(1):322. Epub 2020 Jul 6.

Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

Objectives: Infection with the bacteria Helicobacter pylori has been classified as class one carcinogen associated with increasing susceptibility of gastritis and gastric carcinoma. This study is aiming at investigating the prevalence of H. pylori among colon polyps and colon cancer patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13104-020-05159-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339555PMC

Glypican-1 Level Is Elevated in Extracellular Vesicles Released from MC38 Colon Adenocarcinoma Cells Overexpressing Snail.

Cells 2020 Jun 30;9(7). Epub 2020 Jun 30.

CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Université de Reims Champagne Ardenne, 51100 Reims, France.

The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastatic potential. The aim of this study was to analyze the effect of Snail on murine colon adenocarcinoma cells (MC38 line) and on the characteristics of their EVs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9071585DOI Listing

Characterization and antitumor activity of novel exopolysaccharide APS of Lactobacillus plantarum WLPL09 from human breast milk.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China. Electronic address:

Two exopolysaccharides, NPS and APS, were isolated from L. plantarum WLPL09 and purified by ion-exchange chromatography. The structural analyses showed that molecular weight of NPS and APS were 72. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.277DOI Listing

Topical aloe vera for the treatment of cetuximab-related acneiform rash in colorectal cancer: A case report.

J Oncol Pharm Pract 2020 Jul 5:1078155220937751. Epub 2020 Jul 5.

Faculty of Medicine, Department of Medical Oncology, Ankara University, Ankara, Turkey.

Introduction: Colorectal cancer is one of the most common cancers in the world. Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor which provides survival benefit when combined with chemotherapy in RAS wild type metastatic colorectal cancer. Cutaneous toxicities associated with cetuximab have a significant impact on patient quality of life, treatment continuation and healthcare resource utilization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1078155220937751DOI Listing

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Nat Commun 2020 Jul 3;11(1):3353. Epub 2020 Jul 3.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-16483-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335068PMC

Proposal of a Classification System for Adenocarcinoma Involving the Ileocecal Valve (Bauhin's Valve): A Retrospective Study of 689 Right Hemicolectomized Patients.

Anticancer Res 2020 Jul;40(7):4053-4057

Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology "Sapienza", St. Andrea Hospital, Rome, Italy.

Background/aim: As of 2020, adenocarcinoma arising in the ileocecal valve (ICV-A) has been examined along with cecal and right colon cancer (RCC) under the collective heading "ileocecal" tumor. We propose a new classification system for this cancer.

Patients And Methods: We retrospectively analyzed RCC patients from 2003 to 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14402DOI Listing

Synchronous Primary Pancreatic Ductal Carcinoma and Colonic Adenocarcinoma Present in a Patient With History of Skin Squamous Cell Carcinoma.

Anticancer Res 2020 Jul;40(7):4029-4032

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

The synchronous diagnosis of two or more primary malignancies in a patient is overall rare. This is a case report of a 70-year-old female with a history of skin squamous cell carcinoma presenting with occult hematochezia. Colonoscopy and biopsy results confirmed a microsatellite stable (MMS) adenocarcinoma in the ascending colon, and subsequent computed tomography (CT) scans identified a 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14398DOI Listing

Lynch syndrome-associated colorectal cancer in a 16-year-old girl due to a mutation.

BMJ Case Rep 2020 Jul 1;13(7). Epub 2020 Jul 1.

Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA

The diagnosis of paediatric colorectal cancer is an unusual finding often diagnosed at an advanced stage with associated poor survival. Paediatric colorectal cancer warrants investigation for hereditary cancer predisposition syndromes, including Lynch syndrome. Here we describe a 16-year-old girl who presented with a stage IIA mucinous adenocarcinoma of the descending colon (T3 N0 M0) treated by resection alone that was associated with a pathogenic germline mutation of (c. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-233935DOI Listing

A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report.

BMC Med Genet 2020 Jul 1;21(1):141. Epub 2020 Jul 1.

Department of Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1, Aoyama-cho, Kure City, Hiroshima, 737-0023, Japan.

Background: Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12881-020-01079-xDOI Listing

[Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):710-714

Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Department of Pathology, Drum Tower School of Clinical Medicine, Nanjing Medical University, Nanjing 210008, China.

To investigate the clinicopathologic and immunophenotypic features of metastatic gastrointestinal hepatoid adenocarcinomas in the liver. Eight cases of hepatic metastatic gastrointestinal hepatoid adenocarcinoma diagnosed at the Affiliated Drum Tower Hospital, Nanjing University Medical School from January 2009 to January 2019 were retrospectively analyzed. The clinical data, histopathologic features and immunohistochemical (IHC) characteristics performed by EnVision method were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112151-20191123-00753DOI Listing

Cancer-associated point mutations in the DLC1 tumor suppressor and other Rho-GAPs occur frequently and are associated with decreased function.

Cancer Res 2020 Jun 30. Epub 2020 Jun 30.

Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute

In advanced cancer, the RHOA GTPase is often active together with reduced expression of genes encoding Rho-specific GTPase-accelerating proteins (Rho-GAP), which negatively regulate RHOA and related GTPases. Here we used the TCGA dataset to examine 12 tumor types (including colon, breast, prostate, pancreas, lung adenocarcinoma and squamous cell carcinoma) for the frequency of codon mutations of 10 Rho-GAP and experimentally tested biochemical and biological consequences for cancer-associated mutants that arose in the DLC1 tumor suppressor gene. DLC1 was the Rho-GAP gene mutated most frequently, with 5-8% of tumors in five of the tumor types evaluated having DLC1 missense mutations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-3984DOI Listing

Functional network analysis reveals an immune tolerance mechanism in cancer.

Proc Natl Acad Sci U S A 2020 Jun 29. Epub 2020 Jun 29.

Department of Computer Science, Stony Brook University, New York, NY 11794.

We present a technique to construct a simplification of a feature network which can be used for interactive data exploration, biological hypothesis generation, and the detection of communities or modules of cofunctional features. These are modules of features that are not necessarily correlated, but nevertheless exhibit common function in their network context as measured by similarity of relationships with neighboring features. In the case of genetic networks, traditional pathway analyses tend to assume that, ideally, all genes in a module exhibit very similar function, independent of relationships with other genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2002179117DOI Listing

Prediction and identification of immune genes related to the prognosis of patients with colon adenocarcinoma and its mechanisms.

World J Surg Oncol 2020 Jun 29;18(1):146. Epub 2020 Jun 29.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Aahui, China.

Background: Colon adenocarcinoma (COAD) is a gastrointestinal tumor with a high degree of malignancy. Its deterioration process is closely related to the tumor microenvironment, and transcription factors (TF) play a regulatory role in this process. Currently, there is a lack of exploration between the genes related to the COAD tumor microenvironment and the survival prognosis of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12957-020-01921-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325073PMC

Effect of Different Expression of Immune-Related lncRNA on Colon Adenocarcinoma and Its Relation to Prognosis.

Biomed Res Int 2020 6;2020:6942740. Epub 2020 Jun 6.

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Objective: To explore the expression of immune-related lncRNAs in colon adenocarcinoma and find out the effect on how these lncRNAs influence the development and prognosis of colon adenocarcinoma.

Method: Transcriptome data of colon adenocarcinoma from The Cancer Genome Atlas (TCGA) were downloaded, and gene sets "IMMUNE RESPONSE" and "IMMUNE SYSTEM PROCESS" were sought from the Molecular Signatures Database (MSigDB). The expression of immune-related genes was extracted that were immune-related mRNAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/6942740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294360PMC

and Concomitant Mutations in a Patient with Metastatic Colon Adenocarcinoma: An Interesting Case Report.

Case Rep Oncol 2020 May-Aug;13(2):595-600. Epub 2020 Jun 4.

Unità di Oncologia Medica, Ospedale S.G. Moscati, Taranto, Italy.

A 68-year-old female patient with tenesmus and blood in the stool was admitted to the S.G. Moscati Hospital of Taranto. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000507882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315173PMC

[Changes in the classification of malignant colon epithelial neoplasms. (WHO, 2019, 5th edition)].

Arkh Patol 2020 ;82(3):38-46

M.V. Lomonosov Moscow State University, Medical Research and Educational Center, Moscow, Russia.

There are not many changes compared to 2010 in WHO classification (2019) of colon adenocarcinomas. Cribriform comedo-type adenocarcinoma (ICD-O code: 8201/3), spindle cell carcinoma (8032/3), squamous cell carcinoma (8070/3) are excluded; carcinoma with a sarcomatoid component (8033/3), poorly cohesive carcinoma (8490/3) and adenoma-like adenocarcinoma (8262/3) were added. The important histological characteristics in the conclusion should indicate the presence of lymphatic invasion, intra- and extramural vascular invasion, perineural invasion, grading, «tumor budding» and the immune microenvironment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/patol20208203138DOI Listing
January 2020

Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model.

J Nutr Biochem 2020 May 19;83:108418. Epub 2020 May 19.

Department of Medicine, Universitat de Lleida, Lleida, Catalonia, Spain; Institut de Recerca Biomèdica de Lleida, Fundació Dr. Pifarré-IRBLleida, Lleida, Catalonia, Spain. Electronic address:

Colorectal cancer (CRC) is the fourth cancer with the most new cases reported in 2018 worldwide. Consumption of fruit and vegetables is a protective factor against the risk of CRC. Beyond this, flavonoids could orchestrate these healthy effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jnutbio.2020.108418DOI Listing

Dysplastic Progression to Adenocarcinoma is Equivalent in Ulcerative Colitis and Crohn's disease.

J Crohns Colitis 2020 Jun 27. Epub 2020 Jun 27.

Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland OH.

Background: We sought to determine the rate of progression from dysplasia to adenocarcinoma in UC versus CD and describe risk factors unique to each.

Methods: All adult patients (> 18 years) with a known diagnosis of either UC or CD who underwent a surveillance colonoscopy between January 1, 2010 and January 1, 2020 were included.

Results: A total of 23,751 surveillance colonoscopies were performed among 12,289 between 1/1/2010 and 1/1/2020; 6909 (56. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ecco-jcc/jjaa133DOI Listing

Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage.

Chem Biol Drug Des 2020 Jun 26. Epub 2020 Jun 26.

Research Center of Clinical Medical, Affiliated Hospital of Nantong University, Nantong, China.

Eighteen new β-carboline-based indole-4,7-quinone derivatives (12a-i and 13a-i) were designed and synthesized, and their in vitro and in vivo antiproliferative activities were studied. Most of target compounds showed strong inhibition on three human tumor cells' proliferation. In particular, the most active compound 13g not only displayed more prominent antiproliferative activities than β-lapachone, a clinical antitumor candidate, but also exerted significant NAD(P)H: quinone-oxidoreductase-1 (NQO1) inhibitory activity and NQO1-dependent cytotoxicity in HT29 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cbdd.13752DOI Listing

A machine learning-based prognostic predictor for stage III colon cancer.

Sci Rep 2020 Jun 25;10(1):10333. Epub 2020 Jun 25.

Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, China.

Limited biomarkers have been identified as prognostic predictors for stage III colon cancer. To combat this shortfall, we developed a computer-aided approach which combing convolutional neural network with machine classifier to predict the prognosis of stage III colon cancer from routinely haematoxylin and eosin (H&E) stained tissue slides. We trained the model by using 101 cancers from West China Hospital (WCH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316723PMC

Natural photosensitizers in Photodynamic Therapy: in vitro activity against monolayers and spheroids of human colorectal adenocarcinoma SW480 cells.

Photodiagnosis Photodyn Ther 2020 Jun 22:101852. Epub 2020 Jun 22.

Departamento de Biología Molecular, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, CP 5800 Río Cuarto, Córdoba, Argentina.

Photodynamic Therapy (PDT), a promising treatment option for cancer.It involves the photochemical interaction of light, photosensitizer (PS) and molecular oxygen to produce radical species as well as singlet oxygen which induce cell death. Anthraquinones (AQs) have been extensively studied with respect to their UV/Vis absorption characteristics and their photosensitizing properties in photodynamic reactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2020.101852DOI Listing

Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values.

Pathol Oncol Res 2020 Jun 24. Epub 2020 Jun 24.

Department of Biopathology, Academic Hospital, rue du Général Koenig, 51100, Reims, France.

Describe clinical, histological and molecular charatcteristics and prognosis values of the serrated candidate markers AnnexinA10 and Gremlin1 in colon adenocarcinomas. Immunohistochemical expression of AnnexinA10 and Gremlin1 was evaluated on 346 colonic adenocarcinomas. Clinicopathological, molecular features and prognostic characteristics were then evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12253-020-00857-5DOI Listing

Metastatic Colorectal Cancers with Mismatch Repair Deficiency Result in Worse Survival Regardless of Peritoneal Metastases.

Ann Surg Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, University of Chicago, Chicago, IL, USA.

Background: Mismatch-repair deficiency (dMMR) predicts worse chemoresponsiveness but better survival in early-stage colorectal adenocarcinoma. This study examined metastatic colorectal and appendix cancers with and without peritoneal metastasis (PM) in the National Cancer Database (NCDB), hypothesizing that dMMR tumors show better survival.

Methods: Stage 4 colon, rectum, and appendix cancers (2010-2016) were identified in the NCDB (including goblet cell carcinoids, excluding neuroendocrine tumors). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08733-xDOI Listing

Mucinous Histology Might Be an Indicator for Enhanced Survival Benefit of Chemotherapy in Stage II Colon Cancer.

Front Med (Lausanne) 2020 5;7:205. Epub 2020 Jun 5.

Department of General Surgery, Jiangdu People's Hospital Affiliated to Medical College of Yangzhou University, Yangzhou, China.

It was a difficult question to identify candidates who would benefit most from adjuvant chemotherapy in stage II colon cancer because of the paucity of relevant conclusive clinical trial results. We aimed to assess if mucinous adenocarcinoma (MUA) could be an indicator for the efficacy of adjuvant chemotherapy in stage II colon cancer. Using SEERStat software V. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2020.00205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290047PMC

Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Front Oncol 2020 9;10:917. Epub 2020 Jun 9.

Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Colorectal adenocarcinoma with mucinous component (AWMC) is a special entity of colorectal cancer. The study is aimed at analyzing the clinicopathological characteristics, mutation spectrum, and prognosis of AWMC and comparing it with classical adenocarcinoma (AC) in a Chinese cohort. One hundred eight AMWC and 204 AC patients were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296099PMC

Ascending colon cancer with synchronous right external iliac lymph node metastasis.

Int Cancer Conf J 2020 Jul 27;9(3):162-167. Epub 2020 May 27.

Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Japan.

A 75-year-old woman was diagnosed with anemia during hospitalization for the treatment of right superior ophthalmic arteriovenous fistula. Colonoscopy revealed an entire circumference of type 2 tumor in the ascending colon. Computed tomography showed ascending colon wall thickening, a tumor with a maximum diameter of 32 mm on the right external iliac artery and multiple low-density nodules in the spleen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13691-020-00419-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297901PMC

MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.

J Immunother Cancer 2020 Jun;8(1)

Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, United States

Background: Immune checkpoint inhibitors, the most widespread class of immunotherapies, have demonstrated unique response patterns that are not always adequately captured by traditional response criteria such as the Response Evaluation Criteria in Solid Tumors or even immune-specific response criteria. These response metrics rely on monitoring tumor growth, but an increase in tumor size and/or appearance after starting immunotherapy does not always represent tumor progression, but also can be a result of T cell infiltration and thus positive treatment response. Therefore, non-invasive and longitudinal monitoring of T cell infiltration are needed to assess the effects of immunotherapies such as checkpoint inhibitors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jitc-2019-000328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312343PMC

Hairy Garlic () from Sicily (Italy): LC-DAD-MS Analysis of Secondary Metabolites and In Vitro Biological Properties.

Molecules 2020 Jun 19;25(12). Epub 2020 Jun 19.

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35128 Padova, Italy.

, known as hairy garlic, is a bulbous plant widespread in the Mediterranean area and locally used as a food and spice. In the present study, the chemical profile of the ethanolic extracts from bulbs (BE) and aerial parts (APE) were analyzed by HPLC-ESI-MS, and antioxidant properties were evaluated by DPPH, ABTS and TEAC assays. The traditional use in the diet, and the well documented biological activity of species suggest a potential as a new nutraceutical. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules25122837DOI Listing

Preventive intraperitoneal hyperthermic perfusion chemotherapy for patients with T4 stage colon adenocarcinoma.

Tech Coloproctol 2020 Jun 22. Epub 2020 Jun 22.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to be an effective treatment for peritoneal tumors; whether preventive HIPEC after radical resection for T4 stage colon adenocarcinoma could decrease peritoneal recurrence remains unknown. The aim of the present study was to compare peritoneal recurrence and short-term survival in patients with T4 stage colon adenocarcinoma undergoing HIPEC plus adjuvant chemotherapy or adjuvant chemotherapy alone following surgery.

Methods: We retrospectively reviewed T4 stage colon adenocarcinoma patients who had radical tumor resection at our institution between January 2014 and January 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10151-020-02270-1DOI Listing

Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles.

Invest Radiol 2020 Jun 18. Epub 2020 Jun 18.

Cardiovascular Division, Department of Medicine, Robert M Berne Cardiovascular Research Center, Department of Radiology, and Department of Biomedical Engineering, University of Virginia, Charlottesville.

Purpose: Molecular ultrasound imaging of tumor vasculature is being actively investigated with microbubble contrast agents targeted to neovasculature biomarkers. Yet, a universal method of targeting tumor vasculature independent of specific biomarkers, or in their absence, would be desirable. We report the use of electrostatic interaction to achieve adherence of microbubbles to tumor vasculature and resulting tumor delineation by ultrasound imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000699DOI Listing

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video.

J Vis Exp 2020 Jun 6(160). Epub 2020 Jun 6.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam;

Radical resection margins, resection of Gerota's (perirenal) fascia, and adequate lymph node dissection are crucial for an adequate oncological resection of left-sided pancreatic cancer. Several surgical techniques have been described in recent years, but few were specifically designed for minimally invasive approaches. This study describes and demonstrates a standardized and reproducible technique for an adequate oncological resection of pancreatic cancer: laparoscopic radical left pancreatectomy (LRLP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/60332DOI Listing

Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer.

Dis Markers 2020 20;2020:3159831. Epub 2020 May 20.

Department of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, China.

Background: The association of miR-28-5p with colon cancer remains to be elucidated. This study aimed to determine the clinical significance and prognostic value of miR-28-5p in colon cancer.

Methods: We retrospectively analyzed the data of miR-28-5p in colon adenocarcinoma data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and the data was divided into cancer group and normal group, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3159831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256711PMC

Distinct diagnostic and prognostic values of γ-aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma.

Oncol Lett 2020 Jul 24;20(1):275-291. Epub 2020 Apr 24.

Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

In the present study, the significance of genes in colon adenocarcinoma (COAD) were investigated from the view of diagnosis and prognosis. All data were achieved from The Cancer Genome Atlas. Overall survival was analyzed by the Kaplan-Meier analyses and Cox regression model and the hazard ratios and 95% confidence interval were calculated for computation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2020.11573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286117PMC

Colorectal neuroendocrine tumors: A case series.

Int J Surg Case Rep 2020 Jun 12;72:411-417. Epub 2020 Jun 12.

Department of Surgery, Faculty of Medicine, Hasanuddin University Makassar, Indonesia. Electronic address:

Introduction: Neuroendocrine tumors (NET) of the colon and sigmoid colon are uncommon compared to colorectal adenocarcinoma. Few reports have been made of NET of the colon and sigmoid colon that presents with peritonitis and large bowel obstruction.

Case Presentation: Here, we report two cases of NET of the colon and sigmoid colon, which were diagnosed and treated at our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306531PMC

Quadruplicate Synchronous Adenocarcinoma of the Colon with Distant Metastases-Long-Term Molecular Follow-Up by KRAS and TP53 Mutational Profiling.

Diagnostics (Basel) 2020 Jun 16;10(6). Epub 2020 Jun 16.

Department of Pathology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.

Anatomically independent tumor foci represent biologically distinct neoplasias, potentially featured by different progressivity and treatment responsiveness. To demonstrate the biological complexity, a metastatic colon adenocarcinoma patient originally presenting with four independent primary tumors of the right colon half and altogether eight distant metastases was followed by molecular testing. Next-generation sequencing results highlighted the mutational profile of the individual primaries and the dynamics of the different gene variants observed during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10060407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345140PMC

Adenocarcinoma arising from a heterotopic pancreas in the first portion of the duodenum: a case report.

Surg Case Rep 2020 Jun 18;6(1):141. Epub 2020 Jun 18.

Department of Pathology, Fukui-ken Saiseikai Hospital, Fukui, Japan.

Background: Heterotopic pancreas (HP) is defined as pancreatic tissue in organs with no anatomical continuity with the orthotopic pancreas. Based on the number of cases reported in the literature between the year 2000 and 2020, HP is rarely found causing malignant transformation of the duodenum. We herein report a case of adenocarcinoma arising from the HP in the first portion of the duodenum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-020-00903-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303251PMC

Two Histologically Different Primary Malignancies: Synchronous Obstructive Descending Colon Adenocarcinoma and Appendicular Carcinoid Tumor.

Am J Case Rep 2020 Jun 19;21:e921810. Epub 2020 Jun 19.

Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.

BACKGROUND Synchronous primary tumors are defined as 2 or more different histological tumors discovered in one patient at the same time or within a period of 6 months. Colorectal cancer is one of the most common cancers in the United States. Inversely, synchronous colorectal cancer and carcinoid tumors are rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.921810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322214PMC

Data on the evaluation of gene expression in Colorectal Cancer.

Data Brief 2020 Aug 25;31:105765. Epub 2020 May 25.

Center of Marine Sciences (CCMAR), University of Algarve, Faro, 8005-139, Portugal.

The data presented in this article is related with the research paper entitled "Evaluation of MGP gene expression in colorectal cancer", available on Gene journal [1]. From all the transcription factors known to regulate , FGF2 is the most described in colon adenocarcinoma and colon tumor cell lines, where it was shown to: i) contribute for the invasiveness potential; and ii) promote proliferation and survival of colorectal cancer cells. These studies pose the hypothesis that FGF2 associated signaling pathways could be promoting the regulation of others genes, such as that may lead to tumor progression which ultimately could result in poor prognosis in colon adenocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dib.2020.105765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289741PMC