21,292 results match your criteria Colon Adenocarcinoma


Stage I-III colon cancer patients with tumor deposits behave similarly to stage IV patients. Cross-section analysis of 392 patients.

J Surg Oncol 2019 Apr 24. Epub 2019 Apr 24.

Surgical Oncology, Instituto Nacional de Cancerología, Mexico, Mexico.

Background And Objectives: Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colorectal cancer. However, controversy exists regarding their definition, evaluation, and staging categories. This study aimed to determine the survival and recurrence impact of the TD in colon adenocarcinomas; and to determine if TD patients behave similarly to stage IV patients. Read More

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http://dx.doi.org/10.1002/jso.25482DOI Listing
April 2019
2 Reads

Primary vaginal adenocarcinoma of intestinal type or occult metastatic colon cancer: a diagnostic dilemma from a vaginal skin tag.

Int J Womens Health 2019 1;11:223-228. Epub 2019 Apr 1.

Department of Gynaecological Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK,

The presentation of a new vaginal lesion could represent a variety of diagnoses from benign warts to more sinister primary malignancies. Rarely, a new lesion could represent a metastatic deposit from a malignancy elsewhere in the body. Colonic carcinomas are the third most common malignancy, frequently metastasising to the liver and lung. Read More

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http://dx.doi.org/10.2147/IJWH.S142002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448537PMC

Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization.

Micromachines (Basel) 2019 Apr 19;10(4). Epub 2019 Apr 19.

INSERM UMR-S1147, CNRS SNC5014, Paris Descartes University, Equipe Labellisée Ligue Nationale Contre le Cancer, 75005 Paris, France.

Traditional two-dimensional (2D) cell culture models are limited in their ability to reproduce human structures and functions. On the contrary, three-dimensional (3D) microtissues have the potential to permit the development of new cell-based assays as advanced in vitro models to test new drugs. Here, we report the use of a dehydrated gelatin film to promote tumor cells aggregation and 3D microtissue formation. Read More

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http://dx.doi.org/10.3390/mi10040265DOI Listing

Cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.

Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (MCF-7, MDA-MB-231, SK-BR-3), human colon adenocarcinoma (HT-29), human cervix adenocarcinoma (HeLa), human prostate adenocarcinoma (PC-3), Mus musculus neuroblastoma (Neuro 2A) cell lines and African green monkey kidney (VERO) as healthy cell line. Supercritical CO extracts proved to be more active than soxhlet counterparts. Read More

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http://link.springer.com/10.1007/s11033-019-04812-9
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http://dx.doi.org/10.1007/s11033-019-04812-9DOI Listing
April 2019
1 Read

Loss of PKM2 in Lgr5 intestinal stem cells promotes colitis-associated colorectal cancer.

Sci Rep 2019 Apr 17;9(1):6212. Epub 2019 Apr 17.

Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Republic of Korea.

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated the effectiveness of conditionally ablating PKM2 in Lgr5 intestinal stem cells (ISC) using a mouse model of colitis-associated CRC (AOM plus DSS). Read More

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http://www.nature.com/articles/s41598-019-42707-8
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http://dx.doi.org/10.1038/s41598-019-42707-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470145PMC
April 2019
3 Reads

Fast and accurate tumor segmentation of histology images using persistent homology and deep convolutional features.

Med Image Anal 2019 Apr 4;55:1-14. Epub 2019 Apr 4.

Department of Computer Science, University of Warwick, UK; Department of Pathology, University Hospitals Coventry and Warwickshire, UK; The Alan Turing Institute, UK. Electronic address:

Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles (PHPs). For a given image patch, the homology profiles are derived by efficient computation of persistent homology, which is an algebraic tool from homology theory. Read More

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http://dx.doi.org/10.1016/j.media.2019.03.014DOI Listing
April 2019
1 Read

Colorectal Large Cell Neuroendocrine Carcinoma with lymphoid stroma: further evidence confirming a unique sub-type associated with MLH-1/PMS2 protein loss, BRAF mutation, EBV-negativity and possible better prognosis.

Histopathology 2019 Apr 16. Epub 2019 Apr 16.

University Health Network and University of Toronto, Toronto, Canada.

Pure large cell neuroendocrine carcinoma (LCNEC) is an uncommon but well recognized primary tumour of the colorectum. It is characterized by large cells organized in a discernible neuroendocrine pattern, >20 mitoses per 10 HPF and/or Ki-67 index > 20% and, coagulative tumour necrosis is invariably present. These features are supplemented by positive neuroendocrine immunohistochemical markers. Read More

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http://dx.doi.org/10.1111/his.13875DOI Listing
April 2019
1 Read

Single-Center Experience with Magnetic Retraction in Colorectal Surgery.

J Laparoendosc Adv Surg Tech A 2019 Apr 16. Epub 2019 Apr 16.

1 Duke Surgery, Division of Metabolic and Weight Loss Surgery, Durham, North Carolina.

Background: Appropriate tissue retraction is essential in laparoscopic surgery, and colorectal operations often require an additional incision and trocar that can disturb visualization and maneuverability. Each incision carries an increased risk for complications as well as increased pain and cosmetic issues. Magnetic devices have been developed for a less invasive retraction. Read More

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https://www.liebertpub.com/doi/10.1089/lap.2018.0744
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http://dx.doi.org/10.1089/lap.2018.0744DOI Listing
April 2019
2 Reads

Long-term survival after adrenal metastasectomy from colorectal cancer: a report of two cases.

Surg Case Rep 2019 Apr 15;5(1):61. Epub 2019 Apr 15.

Department of Surgery, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634-8522, Japan.

Background: Solitary adrenal metastasis from colorectal cancer is rare. Adrenal metastasis is usually detected with synchronous multiple metastases in other organs and is, therefore, considered to be unsuitable for surgical resection. The long-term outcomes of patients with solitary adrenal metastasectomy from colorectal cancer have been reported; however, the survival advantage has not been established. Read More

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http://dx.doi.org/10.1186/s40792-019-0611-zDOI Listing
April 2019
4 Reads

Metastatic Colorectal Adenocarcinoma in a Bifid Ureter.

J Endourol Case Rep 2019 18;5(1):13-15. Epub 2019 Mar 18.

Department of Urology, New York Medical College, Valhalla, New York.

Secondary malignancies of the ureter are uncommon. We report the diagnosis and management of metastatic colon cancer to the bifurcation of a bifid ureter. A 59-year-old man presented with diffuse metastasis with right hydronephrosis in both renal moieties of a partially duplicated system and an enhancing lesion within the proximal common ureter. Read More

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http://dx.doi.org/10.1089/cren.2018.0100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461055PMC
March 2019
1 Read

Colitis cystica profunda of the rectum with adenomatous dysplastic features: Radiologic-pathologic correlation.

Radiol Case Rep 2019 Jun 3;14(6):740-745. Epub 2019 Apr 3.

Radiology Department, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso 86100, Italy.

Colitis cystica profunda is a rare nonneoplastic condition characterized by the presence of mucus-containing cysts in the submucosa of the right colon and rectum. The etiology is unclear, with a few cases reported in the literature. The presenting symptoms and signs may mimic colorectal adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447733PMC
June 2019
2 Reads

Gut-associated lymphoid tissue or so-called "dome" carcinoma of the colon: Review.

World J Gastrointest Oncol 2019 Jan;11(1):59-70

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto ON, Canada.

Aim: To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.

Methods: The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised.

Results: GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i1.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451924PMC
January 2019
2 Reads

Synthesis, anticancer activity and molecular modeling studies of novel chalcone derivatives containing indole and naphthalene moieties as tubulin polymerization inhibitors.

Chem Pharm Bull (Tokyo) 2019 Apr 13. Epub 2019 Apr 13.

Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University.

Eighteen novel chalcone derivatives containing indole and naphthalene moieties (2-19) were synthesized and characterized by H NMR, C NMR and HRMS spectra. All compounds were evaluated for their in vitro cytotoxic potential against human hepatocellular carcinoma (HepG2), human colon carcinoma (HCT116) and human breast adenocarcinoma (MCF-7) cell lines. Among them, compound 2, 3, 4 and 7 showed potent activities against tested cancer cell lines. Read More

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http://dx.doi.org/10.1248/cpb.c19-00217DOI Listing
April 2019
1 Read

Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Epithelial cell polarity regulator Crumbs3 (Crb3), a mammalian homolog within the Drosophila Crb gene family, was initially identified as an essential embryonic development factor. It is recently implicated in tumor suppression, though its specific functions are controversial. We here demonstrate that Crb3 strongly promotes tumor invasion and metastasis of human colon adenocarcinoma cells. Read More

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http://dx.doi.org/10.1002/ijc.32336DOI Listing
April 2019
1 Read

Next Generation Proteomics for Clinical Biomarker Detection Using SWATH-MS.

Methods Mol Biol 2019 ;1977:3-15

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

The technology of "sequential windowed acquisition of all theoretical fragment ion spectra," known as SWATH-MS, is rapidly gaining popularity as a next generation proteomics technology for comprehensive proteome quantitation. In this chapter, we describe the use of SWATH-MS as a label-free quantitative technique in a proteomics study to identify novel serological biomarker for colorectal cancer. We compared the secreted glycoprotein profiles (glyco-secretomes) enriched from the colon adenocarcinoma cell line HCT-116 and its metastatic derivative, E1, and observed that laminin β-1 (LAMB1) was oversecreted in E1 cells. Read More

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http://link.springer.com/10.1007/978-1-4939-9232-4_1
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http://dx.doi.org/10.1007/978-1-4939-9232-4_1DOI Listing
January 2019
5 Reads

Re-evaluation of polihexanide use in wound antisepsis in order to clarify ambiguities of two animal studies.

J Wound Care 2019 Apr;28(4):246-255

Consultant Clinical Microbiology and Infection Control, Consultant Infectious Diseases and Tropical Medicine, Department for Hospital Epidemiology and Infection Control, Medical University of Vienna, Austria.

Objective: Due to classification of the agent polihexanide (PHMB) in category 2 'may cause cancer' by the Committee for Risk Assessment of the European Chemicals Agency in 2011, the users of wound antiseptics may be highly confused. In 2017, this statement was updated, defining PHMB up to 0.1% as a preservative safe in all cosmetic products. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.4.246DOI Listing
April 2019
5 Reads

Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application.

Mol Pharm 2019 Apr 18. Epub 2019 Apr 18.

Section of Thoracic Surgery, Department of Surgery , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States.

Tumor targeting agents are being developed for early tumor detection and therapeutics. We previously identified the peptide SNFYMPL (SNF*) and demonstrated its specific binding to human esophageal specimens of high-grade dysplasia (HGD) and adenocarcinoma with imaging ex vivo. Here, we aim to identify the target for this peptide and investigate its potential applications in imaging and drug delivery. Read More

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00185
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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00185DOI Listing
April 2019
1 Read
4.384 Impact Factor

Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4-17 against Escherichia coli causing urinary tract infection in humans.

Microb Pathog 2019 Apr 8;131:246-253. Epub 2019 Apr 8.

Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Gastrointestinal (GI) infection is one of the most common types of infectious diseases. Application of probiotic strains in the control of such infections represents a promising approach. In this study, Lactobacillus fermentum strain 4-17 was isolated from kashkineh, an Iranian cereal fermented food, and identified by sequencing its 16S rRNA gene using universal primers. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.006DOI Listing
April 2019
2 Reads

Apoptosis-inducing activities of Halopteris scoparia L. Sauvageau (Brown algae) on cancer cells and its biosafety and antioxidant properties.

Cytotechnology 2019 Apr 9. Epub 2019 Apr 9.

Faculty of Science, Department of Biology, Ege University, Bornova, Izmir, 35100, Turkey.

The aim of this study was to reveal the biological activities and in vivo toxicity profiles of n-hexane, chloroform and methanol extracts of brown algae Halopteris scoparia L. Sauvageau. In this study, extracts were tested for their phytochemical contents and antioxidant activities. Read More

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http://dx.doi.org/10.1007/s10616-019-00314-5DOI Listing
April 2019
1 Read

Inferior gluteal artery surgical access for embolization of large internal iliac artery aneurysm in a hostile abdomen.

J Surg Case Rep 2019 Apr 6;2019(4):rjz098. Epub 2019 Apr 6.

Vascular Unit, 1st University Surgical Department, Aristotle University, Papageorgiou General Hospital, Thessaloniki 56403, Greece.

Introduction: Internal iliac artery aneurysms (IIAA) are a rare entity compared with all aortoiliac aneurysms. Continuous expansion due to retrograde flow from runoff vessels can lead to rupture with devastating results. Exclusion of the aneurysm represents a challenging procedure especially if the access is limited and the patient has a history of reoperations in the pelvic region. Read More

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http://dx.doi.org/10.1093/jscr/rjz098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451179PMC

Cutaneous metastasis in adenocarcinoma rectum.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India.

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http://dx.doi.org/10.1136/bcr-2019-229652DOI Listing
April 2019
2 Reads

The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma.

BMC Med Genet 2019 Apr 9;20(Suppl 1):52. Epub 2019 Apr 9.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Background: CpG island methylator phenotype (CIMP) is found in 15-20% of malignant colorectal tumors and is characterized by strong CpG hypermethylation over the genome. The molecular mechanisms of this phenomenon are not still fully understood. The development of CIMP is followed by global gene expression alterations and metabolic changes. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
Publisher Site
http://dx.doi.org/10.1186/s12881-019-0771-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454590PMC
April 2019
8 Reads

SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer.

Mod Pathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

DNA mismatch repair protein deficient colon cancer frequently displays reduced CDX2 expression, and recent literature has suggested that negative CDX2 expression is a poor prognostic biomarker in colon cancer. We have recently demonstrated that SATB2 is an immunohistochemical marker that is complementary to CDX2. Using a tissue microarray approach, we evaluated SATB2 and CDX2 immunohistochemical expression in 514 patients with colonic adenocarcinoma including 146 with mismatch repair protein deficient tumors and correlated expression with histopathologic variables, molecular alterations, and survival. Read More

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http://dx.doi.org/10.1038/s41379-019-0265-1DOI Listing
April 2019
1 Read

Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models.

Cells 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Antibodies blocking the programmed death-ligand 1 (PD-L1) have shown impressive and durable responses in clinical studies. However, this type of immunotherapy is only effective in a subset of patients and not sufficient for rejection of all tumor types. In this study, we explored in two mouse tumor models whether the antitumor effect could be enhanced by the combined blockade of PD-L1 and transforming growth factor-β (TGF-β), a potent immunosuppressive cytokine. Read More

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http://dx.doi.org/10.3390/cells8040320DOI Listing
April 2019
3 Reads

Properties and bioavailability assessment of shrimp astaxanthin loaded liposomes.

Food Sci Biotechnol 2019 Apr 30;28(2):529-537. Epub 2018 Oct 30.

1Department of Fishery Products, Faculty of Fisheries, Kasetsart University, Bangkok, 10900 Thailand.

This study aimed to investigate the effects of phospholipid composition on the properties and bioavailability of astaxanthin-loaded liposomes using cell culture. Two mixtures of phospholipids with different proportions of phosphatidylcholine (PC, 23% and 70%) were used at various concentrations (0.8, 1. Read More

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http://dx.doi.org/10.1007/s10068-018-0495-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431342PMC

[Clinicopathological significance of poorly differentiated clusters in colorectal adenocarcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):276-281

Department of Pathology, Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China.

To investigate the correlation between poorly differentiated clusters (PDCs) in colorectal adenocarcinomas with clinicopathological parameters and its clinicopathological significance. One hundred and eighty-three colorectal adenocarcinomas resected by radical proctocolecomy were collected at Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, from January to December 2017. There were 122 male and 61 female patients with age ranging from 42 to 89 years (mean of 68 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.003DOI Listing
April 2019
2 Reads

Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles.

Anticancer Res 2019 Apr;39(4):1705-1710

University College London Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, Royal Free Campus, London, U.K.

Background/aim: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its expression has been demonstrated in malignancies including prostate cancer.

Materials And Methods: Near-infrared-emitting gold nanoparticles (AuNPs) were synthesized and conjugated to MGF. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13276DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Cytoreductive surgery and HIPEC in a 14 years old patient with peritoneal recurrence of adenocarcinoma of the right colon.

Int J Surg Case Rep 2019 Mar 21;57:118-121. Epub 2019 Mar 21.

Department of Surgery, University of Modena and Reggio Emilia - Policlinico of Modena, Via del Pozzo, 71, 41100 Modena, Italy. Electronic address:

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is nowadays a feasible and effective treatment for peritoneal metastasis. We present a case of a 14 years old child with peritoneal metastasis from recurrent colorectal cancer.

Presentation Of Case: Colonoscopy and CT-scan were performed leading to the diagnosis of a stenosing adenocarcinoma of the right colon in 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193011
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http://dx.doi.org/10.1016/j.ijscr.2019.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447933PMC
March 2019
2 Reads

Isolated Drain Site Metastasis After Open Resection in Ileal Adenocarcinoma-an Uncommon Site.

Indian J Surg Oncol 2019 Mar 12;10(1):37-39. Epub 2018 May 12.

Department of Surgical Oncology, JIPMER, Puducherry, Puducherry, India.

Although port site implants have been described after laparoscopic resection for gastrointestinal malignancies, drain site metastasis in solid intra-abdominal tumor after open resection is a rare phenomenon. Only few cases have been reported in literature describing drain site metastasis after open resection for carcinoma in the colon, stomach, cervix etc. Isolated drain site metastasis is even rare. Read More

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http://dx.doi.org/10.1007/s13193-018-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414717PMC
March 2019
3 Reads

Inflammation-dependent overexpression of c-Myc enhances CRL4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

J Pathol 2019 Apr 3. Epub 2019 Apr 3.

Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, China.

Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as IL-6 and TNF-α can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-RING E3 Ligases (CRLs) are emerging as master regulators controlling tumorigenesis. Read More

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http://dx.doi.org/10.1002/path.5273DOI Listing
April 2019
4 Reads
7.429 Impact Factor

Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content.

J Muscle Res Cell Motil 2019 Apr 3. Epub 2019 Apr 3.

Department of Physical Therapy, University of Florida, 1275 Center Drive, Gainesville, FL, 32610, USA.

The present study aimed to determine the impact of colon 26 adenocarcinoma (C26)-induced cancer cachexia on skeletal muscle mitochondrial respiration and content. Twelve male CD2F1 mice were injected with C26-cells (tumor bearing (TB) group), whereas 12 age-matched mice received PBS vehicle injection (non-tumor bearing (N-TB) group). Mitochondrial respiration was studied in saponin-permeabilized soleus myofibers. Read More

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http://dx.doi.org/10.1007/s10974-019-09510-4DOI Listing
April 2019
2 Reads

ALPHLARD-NT: Bayesian Method for Human Leukocyte Antigen Genotyping and Mutation Calling through Simultaneous Analysis of Normal and Tumor Whole-Genome Sequence Data.

J Comput Biol 2019 Apr 3. Epub 2019 Apr 3.

4 Health Intelligence Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Human leukocyte antigen (HLA) genes provide useful information on the relationship between cancer and the immune system. Despite the ease of obtaining these data through next-generation sequencing methods, interpretation of these relationships remains challenging owing to the complexity of HLA genes. To resolve this issue, we developed a Bayesian method, ALPHLARD-NT, to identify HLA germline and somatic mutations as well as HLA genotypes from whole-exome sequencing (WES) and whole-genome sequencing (WGS) data. Read More

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http://dx.doi.org/10.1089/cmb.2018.0224DOI Listing
April 2019
2 Reads

Antiproliferative effects of propofol and lidocaine on the colon adenocarcinoma microenvironment.

J BUON 2019 Jan-Feb;24(1):106-115

Department of Anesthesia and Intensive Care, Ion Chiricuta Clinical Research Center, Cluj-Napoca, Romania.

Purpose: Certain anesthetic interventions may influence the postoperative outcome in surgical cancer patients. Our study investigated the antiproliferative effects of propofol and lidocaine in two colon cancer cells lines, fibroblasts and in co-cultures.

Methods: The antiproliferative effects of concentrations of propofol and lidocaine were assessed in HCT-116 and RKO cell lines, in fibroblasts (CCD-18Co) and in co-culture system. Read More

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April 2019
1 Read

Understanding malignant transformation of endometriosis: imaging features with pathologic correlation.

Abdom Radiol (NY) 2019 Apr 2. Epub 2019 Apr 2.

Department of Diagnostic Radiology, Abdominal Division, Mayo Clinic Hospital, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose: Transformation of benign endometriosis to endometriosis-associated ovarian carcinoma (EAOC) is rare; however, women with endometriosis are four times more likely to develop EAOC which can present 20 years earlier than de novo ovarian cancer. Presenting symptoms are often vague and the radiologist's role in recognizing EAOC is critical for early detection and treatment. Histopathologic evaluation remains the mainstay for definitive diagnosis. Read More

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http://dx.doi.org/10.1007/s00261-019-01914-7DOI Listing
April 2019
4 Reads

Costs for Colon Cancer Treatment Comparing Benefit Types and Care Sources in the US Military Health System.

Mil Med 2019 Apr 3. Epub 2019 Apr 3.

Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, 11300 Rockville Pike, Suite 1120, Rockville, MD 20852.

Introduction: Cancer is one of the leading causes of morbidity and mortality in the USA, contributing largely to US healthcare spending. Provision of services (direct or purchased) and insurance benefit type may impact cost for cancer care. As a common cause of cancer in both men and women, we aim to compare colon cancer treatment costs between insurance benefit types and care sources in the US Military Health System (MHS) to better understand whether and to what extent these system factors impact cancer care costs. Read More

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http://dx.doi.org/10.1093/milmed/usz065DOI Listing
April 2019
4 Reads

Lymph node yield and tumour subsite are associated with survival in stage I-III colon cancer: results from a national cohort study.

World J Surg Oncol 2019 Apr 2;17(1):62. Epub 2019 Apr 2.

Department of Surgery, Roskilde Hospital, University of Copenhagen, Sygehusvej 10, 4000, Roskilde, Denmark.

Background: It has been suggested that apart from tumour and nodal status, a range of patient-related and histopathological factors including lymph node yield and tumour location seems to have prognostic implications in stage I-III colon cancer. We analysed the prognostic implication of lymph node yield and tumour subsite in stage I-III colon cancer.

Methods: Data on patients with stage I to III adenocarcinoma of the colon and treated by curative resection in the period from 2003 to 2011 were extracted from the Danish Colorectal Cancer Group database, merged with information from the Danish National Patient Register and analysed. Read More

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http://dx.doi.org/10.1186/s12957-019-1604-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446268PMC
April 2019
2 Reads

A Rare Case of Mixed Adenoneuroendocrine Carcinoma of the Ileocecal Valve.

Cureus 2019 Jan 23;11(1):e3942. Epub 2019 Jan 23.

Internal Medicine, Larkin Community Hospital, South Miami, USA.

Mixed adenoneuroendocrine carcinoma (MANEC) is an uncommon neoplasm with uncertain pathophysiology. In order to be classified as MANEC, the tumor must contain at least 30% neuroendocrine cells and 30% adenocarcinoma. The standardization of MANEC treatment has historically been difficult due to the lack of diagnostic histological classification. Read More

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https://www.cureus.com/articles/17376-a-rare-case-of-mixed-a
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http://dx.doi.org/10.7759/cureus.3942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433445PMC
January 2019
7 Reads

Aortitis as a Harbinger of Occult Malignancy.

Case Rep Rheumatol 2019 26;2019:8385630. Epub 2019 Feb 26.

Division of Rheumatology MC 2152, Geisinger Medical Center, 100 N Academy Ave., Danville, PA 17822, USA.

Noninfectious aortitis can be associated with an occult malignancy. Although glucocorticosteroids are often used, there is no clear evidence-based therapy and there is little consensus regarding treatment. Identifying and treating an underlying trigger is the most efficacious therapy. Read More

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http://dx.doi.org/10.1155/2019/8385630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413356PMC
February 2019
5 Reads

Rectal adenocarcinoma with rectoprostatic fistula following prostate brachytherapy.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Urology, Derby Teaching Hospitals NHS Foundation Trust, Derby, UK.

An 80-year-old man with history of prostate cancer successfully treated with brachytherapy was initially thought to have Fournier's gangrene until imaging detected a rectoprostatic fistula. Although this is known to be a rare complication of prostate brachytherapy, in this case the aetiology was a new primary rectal adenocarcinoma. It was not possible to catheterise per urethra owing to the fistula, so he was fitted with suprapubic catheter, and underwent palliative loop colostomy. Read More

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http://dx.doi.org/10.1136/bcr-2018-226151DOI Listing
March 2019
2 Reads

Adjuvant radiation therapy for T4 non-rectal colon adenocarcinoma provides a cause-specific survival advantage: A SEER database analysis.

Radiother Oncol 2019 Apr 16;133:50-53. Epub 2019 Jan 16.

Department of Radiation Oncology, Virginia Commonwealth University Health, United States.

Purpose: While there is no level 1 evidence supporting the use of adjuvant radiotherapy (RT) for non-rectal colon cancer in the modern chemotherapy era, there are studies that suggest a local control benefit. This treatment modality is not part of standard treatment recommendations, and we hypothesized that adjuvant RT provides a benefit in locally advanced disease. Due to the limited number who receive post-operative RT, a national database was searched to provide sufficient power. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.11.026DOI Listing
April 2019
2 Reads

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers.

Molecules 2019 Mar 25;24(6). Epub 2019 Mar 25.

Pharmaceutical Chemistry Department, Faculty of Pharmacy Ain Shams University, Abbassia, Cairo 11566, Egypt.

The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, HepG2, liver hepatocellular carcinoma and MCF-7, human breast adenocarcinoma cell line), in addition to VEGFR-2 enzyme inhibition activity. Compounds , , , and exhibited promising activity against the tested cell lines and weak activity against VEGFR-2. Read More

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http://dx.doi.org/10.3390/molecules24061175DOI Listing
March 2019
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High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma.

Future Oncol 2019 Apr 1;15(10):1085-1095. Epub 2019 Apr 1.

Department of Gastrointestinal Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, UESTC, Chengdu, 610041, PR China.

Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately.

Patients & Methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis.

Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. Read More

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http://dx.doi.org/10.2217/fon-2018-0499DOI Listing
April 2019
4 Reads

Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Asia: a population-based study.

J Gastroenterol Hepatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Background And Aims: Population-based studies on post-colonoscopy colorectal cancer (CRC) from Asia are sparse. We aimed to determine the characteristics and predictive factors and survival of post-colonoscopy CRC in Hong Kong.

Methods: This is a territory-wide retrospective cohort study. Read More

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http://dx.doi.org/10.1111/jgh.14674DOI Listing
April 2019
2 Reads

Laparoscopic high anterior resection for rectal cancer with rare variations of the left renal vessels: A case report.

Asian J Endosc Surg 2019 Mar 31. Epub 2019 Mar 31.

Division of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.

We present a case of rectal cancer with rare variations of the left renal vessels. A man in his 60s underwent endoscopic mucosal resection for an Ip-type lesion in the upper rectum. Histologically, the lesion was a well-differentiated adenocarcinoma that had invaded the deep submucosal layer. Read More

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http://dx.doi.org/10.1111/ases.12705DOI Listing
March 2019
1 Read

From the Gut to the Heart: Cardiac Tamponade due to Lymphatic Metastasis.

Eur J Case Rep Intern Med 2019 11;6(2):001033. Epub 2019 Feb 11.

Internal Medicine Department, Egas Moniz Hospital, Lisbon, Portugal.

Malignant pericardial effusion is common, being reported in 5-15% of all cancer patients. It most commonly arises from metastasis of lymphomas and of tumours of the lung, breast and, infrequently, the gastrointestinal tract. We describe the case of a 76-year-old woman who presented to the emergency room with cervical adenopathies and clinical signs of acute heart failure. Read More

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http://dx.doi.org/10.12890/2019_001033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432822PMC
February 2019
2 Reads

Inferring Bacterial Infiltration in Primary Colorectal Tumors From Host Whole Genome Sequencing Data.

Front Genet 2019 15;10:213. Epub 2019 Mar 15.

Basic Experimental of Natural Science, University of Science and Technology Beijing, Beijing, China.

Colorectal cancer is the third most common cancer worldwide with abysmal survival, thus requiring novel therapy strategies. Numerous studies have frequently observed infiltrating bacteria within the primary tumor tissues derived from patients. These studies have implicated the relative abundance of these bacteria as a contributing factor in tumor progression. Read More

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http://dx.doi.org/10.3389/fgene.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428740PMC
March 2019
1 Read

Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents.

Biol Pharm Bull 2019 ;42(4):638-644

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University.

Oxaliplatin has been used as a first choice for colorectal, gastric and pancreatic cancer, but it induces peripheral neuropathies. Dimethyl fumarate (DMF) is an oral drug for multiple sclerosis with neuroprotective effects on oxidative stress. Using both in vivo and in vitro models, we investigated the effects of DMF on oxaliplatin-induced peripheral neuropathy and other side effects, as well as on the anti-tumor activity of oxaliplatin. Read More

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http://dx.doi.org/10.1248/bpb.b18-00855DOI Listing
January 2019
2 Reads

Protein Hydrolysates from Fenugreek () as Nutraceutical Molecules in Colon Cancer Treatment.

Nutrients 2019 Mar 28;11(4). Epub 2019 Mar 28.

Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université Oran1, 31000 Oran, Algeria.

The application of plant extracts for therapeutic purposes has been used in traditional medicine since the plants are a source of a great variety of chemical compounds that possess biological activity. Actually, the effect of these extracts on diseases such as cancer is being widely studied. Colorectal adenocarcinoma is one of the main causes of cancer related to death and the second most prevalent carcinoma in Western countries. Read More

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http://dx.doi.org/10.3390/nu11040724DOI Listing
March 2019
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Combinatorial Cytotoxic Effects of Gelam Honey and 5-Fluorouracil against Human Adenocarcinoma Colon Cancer HT-29 Cells In Vitro.

Int J Cell Biol 2019 21;2019:3059687. Epub 2019 Feb 21.

Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin, 22200 Besut, Terengganu Darul Iman, Malaysia.

Combination of natural products with chemodrugs is becoming a trend in discovering new therapeutics approach for enhancing the cancer treatment process. In the present study, we aimed to investigate the cytotoxic and apoptosis induction of Gelam honey (GH) combined with or without 5-Fluorouracil (5-FU) on HT-29 cells. The cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to assess cytotoxicity. Read More

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http://dx.doi.org/10.1155/2019/3059687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408991PMC
February 2019
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Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.

Cancer Commun (Lond) 2019 Mar 29;39(1):13. Epub 2019 Mar 29.

Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, P. R. China.

Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC) characterized by the presence of abundant extracellular mucin which accounts for at least 50% of the tumor volume. Mucinous colorectal adenocarcinoma is found in 10%-20% of CRC patients and occurs more commonly in female and younger patients. Moreover, mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage. Read More

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http://dx.doi.org/10.1186/s40880-019-0361-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440160PMC
March 2019
2 Reads