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Front Genet 2021 28;12:666833. Epub 2021 May 28.

Department of General Surgery, The Armed Police Corps Hospital of Anhui, Hefei, China.

MiR-3614-5p has been found in a variety of cancers including colorectal cancer. However, the association of miR-3614-5p with colorectal cancer is still unclear. Based on the Cancer Genome Atlas (TCGA) database, the relationship between miR-3614-5p and colorectal cancer can be proved. Read More

Int J Surg Case Rep 2021 May 28;84:106025. Epub 2021 May 28.

Departement of pathology, Central Hospital of The Army, Dr Mohamed Seghir Nekkache, Ain Naâdja BP 244, 16205 Kouba, Algiers, Algeria.

Introduction And Importance: The association of colonic adenocarcinoma with lymphoma is a rare entity. The purpose of our presentation is to draw the attention of the endoscopist, and the surgeon, to the need to remove any suspicious lesions in the exploration for colorectal cancer. The pathologist should be warned about this association in the face of any unusual change in the lymphatic environment around an adenocarcinoma. Read More

Tech Coloproctol 2021 Jun 13. Epub 2021 Jun 13.

Department of Colorectal Surgery, Pôle des Maladies de l'Appareil Digestif (PMAD), Beaujon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.

Background: After laparoscopic total mesorectal excision (TME) for low or mid-rectal cancer, we observed several cases of anastomotic leakage (AL) in patients with side-to-end anastomosis (STE). Thus, from December 2018, we routinely performed end-to-end anastomosis (ETE). The aim of this study was to assess if this new strategy changed AL and chronic pelvic sepsis rates in our department. Read More

J Cancer Res Clin Oncol 2021 Jun 11. Epub 2021 Jun 11.

Division of Microbiology, Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, India.

Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes several years to complete and recent genomic and proteomic technologies are identifying several targets involved in each step of polyp to carcinoma transformation in a large number of studies. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211024067

Nassau University Medical Center, East Meadow, NY, USA.

The most common subtype of colon cancer is colorectal adenocarcinoma. Compared with other subtypes, such as signet-ring and mucinous, colorectal adenocarcinoma has been found to have lower rates of metastasis. Approximately 20% of colorectal cancer cases present with metastatic disease on initial evaluation. Read More

Ann Coloproctol 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India.

Purpose: Locally advanced colorectal cancer may require an en bloc resection of surrounding organs or structures to achieve complete tumor removal. This decision must weigh the risk of complications of multivisceral resection against the potential survival benefit. The purpose of this study is to review a single-center experience of feasibility of en bloc multivisceral resections for locally advanced colorectal carcinoma and to examine the effect of surgical experience on immediate outcome and rate of R0 resections. Read More

PLoS One 2021 9;16(6):e0252566. Epub 2021 Jun 9.

Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Background: The purpose is to investigate prognosis according to serum CEA levels before and after surgery in patients with stage IIA colon cancer who do not show high-risk features.

Methods: Among the patients diagnosed with colon adenocarcinoma between April 2011 and December 2017, 462 patients were confirmed as low-risk stage IIA after surgery and enrolled. The ROC curve was used to determine cut-off values of pre- and postoperative CEA. Read More

J Coll Physicians Surg Pak 2021 Jun;30(6):752-753

Department of General Surgery, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Null. Read More

Biochem Biophys Rep 2021 Jul 24;26:101031. Epub 2021 May 24.

Department of Gastroenterology and Hepatology, Japan.

Sporadic adenoma or adenocarcinoma is often detected during endoscopic surveillance of patients with ulcerative colitis (UC). However, it is occasionally difficult to distinguish these neoplasms from dysplasia or colitis-associated cancers because of the influence of inflammation. However, the influence of inflammation on sporadic neoplasms is not well characterised. Read More

Am J Case Rep 2021 Jun 7;22:e932239. Epub 2021 Jun 7.

Department of Surgery, National Hospital Organization Higashihiroshima Medical Center, Hiroshima, Japan.

BACKGROUND Malignant tumors, such as lung and breast cancers, can metastasize to the heart. However, cardiac metastasis rarely occurs in colorectal cancer. Cardiac metastasis cases are typically asymptomatic and rarely cause cardiac tamponade. Read More

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Orthopedic Surgery, Hôpital Riviera-Chablais, Rennaz, Switzerland.

A 67-year-old woman underwent a medical check-up by her general practitioner after complaining of atypical pain in the shoulder girdle. Due to the important inflammatory syndrome noticed on blood testing, a polymyalgia rheumatica was suspected and she was started on corticosteroid treatment with good clinical response, but no impact on inflammation. She underwent extensive imaging with a thoraco-abdominal CT scanner that demonstrated a pancreatic mass, then later a PET-CT showed 3 different hyperactive lesions. Read More

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):361-365

Hospital Nacional Guillermo Almenara Irigoyen, EsSalud. Lima, Perú.

Colorectal cancer (CRC) is the third most frequent cancer in the world and the second cause of death of neoplastic origin. Synchronism in CCR is approximately 3-6%. The gastrointestinal tract is the most frequent place where neuroendocrine neoplasms (NNE) settle and a special type of these neuroendocrine carcinomas (CNE) are rare. Read More

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):351-354

Servicio de Cirugía de Colon y Recto, Departamento de Cirugía General y Digestiva, Hospital Nacional Edgardo Rebagliati Martins, EsSalud. Lima, Perú.

The case of a patient with ascending colon cancer and infiltration of the abdominal wall with a proliferative tumor on the skin is presented. This is an 83-year-old man who underwent surgery for an intra-abdominal abscess ten months before admission and develops a colocutaneous fistula. The patient presented a 10 cm diameter proliferative, multilobed, non-painful tumor on the flank and right iliac fossa; the biopsy revealed an adenocarcinoma. Read More

J Surg Case Rep 2021 May 28;2021(5):rjab202. Epub 2021 May 28.

Northwell North Shore/Long Island Jewish, Department of Surgery, Queens, NY 11040, USA.

Complications after pancreatoduodenectomy are common, and range widely in timing of presentation, relation to pancreatobiliary pathology, and necessity of operative intervention. We present a case of a 74-year-old male with history of pancreatoduodenectomy for pancreatic adenocarcinoma who presented 11 months after index operation with cecal volvulus and required emergent right hemicolectomy. Prior history of pancreatoduodenectomy with mobilization of the right colon likely predisposed him to development of this surgical emergency. Read More

Magy Onkol 2021 Jun 15;65(2):113-120. Epub 2021 May 15.

Kísérletes Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.

The in vivo antitumor effect of two NGR sequence containing peptide-daunomycin conjugates was studied on CD13+ Kaposi's sarcoma s.c. tumor model on SCID mice, and on orthotopically developed CD13- HT-29 colon adenocarcinoma SCID mouse model. Read More

Front Oncol 2021 17;11:670490. Epub 2021 May 17.

Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, China.

Background: ALKBH5 and YTHDF1 are regarded as the eraser and reader, respectively, in N6-methyladenosine (m6A) modification. Recently, immune contexture has been drawing increasing attention in terms of the progression and treatment of cancers. This study aimed to determine the relationship between ALKBH5/YTHDF1 and immunological characteristics of colon adenocarcinoma (COAD). Read More

J Food Biochem 2021 Jun 1:e13778. Epub 2021 Jun 1.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.

Recently, insects have aroused the interest of researchers as potential therapeutic resources against malignant diseases such as cancer. In this study, the effects of aqueous extracts from mysore thorn borer (MTB) (Anoplophora chinensis) and mealworm larvae (MWL) (Tenebrio molitor) against cancer cells were investigated. MWL aqueous extract showed higher antiproliferative effects against Caco-2 and HepG2 cells compared to MTB. Read More

Molecules 2021 May 24;26(11). Epub 2021 May 24.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized and tested against Tdp1. All the derivatives exhibited inhibition at low micromolar or nanomolar concentrations with the most potent inhibitors having IC values in the 0. Read More

J Pers Med 2021 May 26;11(6). Epub 2021 May 26.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania.

Colon adenocarcinoma (COAD) remains an important cause of cancer-related mortality worldwide. Epithelial-mesenchymal transition (EMT) is a key mechanism, promoting not only the invasive or metastatic phenotype but also resistance to therapy. Using bioinformatics approaches, we studied the alteration on EMT related genes and its implication on COAD prognostic based on public datasets. Read More

Diagnostics (Basel) 2021 May 28;11(6). Epub 2021 May 28.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Colorectal cancer (CRC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Fibroblast growth factor receptor 4 (FGFR4) is a receptor tyrosine kinase that has been shown to play a key role in cancer development and prognosis via the activation of its downstream oncogenic signaling pathways. The present study aimed to explore the impact of gene polymorphisms on the risk and progression of CRC. Read More

Pharmaceuticals (Basel) 2021 May 6;14(5). Epub 2021 May 6.

Center of Immunology, "Stefan S. Nicolau" Institute of Virology, 030304 Bucharest, Romania.

In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized. The structures of the new compounds were established using elemental analyses, IR and NMR spectral data. The compounds were evaluated for their anticancer potential on two standardized human cell lines, HT-29 (colon adenocarcinoma) and MDA-MB-231 (breast adenocarcinoma). Read More

Microorganisms 2021 May 20;9(5). Epub 2021 May 20.

Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.

This study aims to determine differences in the on- and off-tumor microbiota between patients with right- and left-sided colorectal cancer. Microbiome profiling of tumor and tumor-adjacent biopsies from patients with right-sided ( = 17) and left-sided ( = 7) colorectal adenocarcinoma was performed using 16S ribosomal RNA sequencing. Off-tumor alpha and beta diversity were significantly different between right- and left-sided colorectal cancer patients. Read More

J Funct Biomater 2021 May 20;12(2). Epub 2021 May 20.

Department of Environmental Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, Wolczanska 213 Street, 90-924 Lodz, Poland.

Recently, the modification of the initial structure of biopolymers, mainly chitosan, has been gaining importance with a view to obtain functional forms with increased practicality and specific properties enabling their use in tissue engineering. Therefore, in this article, the properties (structural and biological) of thermosensitive hydrogels obtained from chitosan lactate/chloride and two types of crosslinking agents (β-glycerol phosphate disodium salt pentahydrate and uridine 5'-monophosphate disodium salt) are discussed. The aim of the research is to identify changes in the structure of the biomaterials during conditioning in water. Read More

Nanomaterials (Basel) 2021 May 21;11(6). Epub 2021 May 21.

Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.

Cisplatin is a first-choice chemotherapeutic agent used to treat solid tumors even though the onset of multi-drug resistance and the time-dose side-effects impair its mono-therapeutic application. Therefore, new drug-delivery approaches, based on nanomedicine strategies, are needed to enhance its therapeutic potential in favor of a dose-reduction of cisplatin. Polyunsaturated fatty acids and their metabolism-derived intermediates, as well as lipid peroxidation end-products, are used as adjuvants to improve the effectiveness of chemotherapy. Read More

Molecules 2021 May 1;26(9). Epub 2021 May 1.

Química de Plantas Colombianas, Faculty of Exact and Natural Sciences, Institute of Chemistry, University of Antioquia (UdeA), Calle 70 No. 52-21, Medellín AA 1226, Colombia.

We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids and (for SW480) and , and (for SW620) displayed the best cytotoxic activity with IC values ranging from 11. Read More

Pol J Pathol 2021 ;72(1):39-47

Assistant professor of Pathology, Faculty of Medicine, Minia University, Minia, Egypt.

Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a high level of mortality and morbidity. In this study we evaluate expression of p-p38 and p-MSK1 in CRC and determine whether there is an association between expression of these markers and any clinicopathologic parameters that could be of prognostic value. Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data. Read More

Gut 2021 May 31. Epub 2021 May 31.

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Objective: Enhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns in tumour progression, heterogeneity of these patterns and imparted therapeutic opportunities remain poorly described.

Design: We performed comprehensive epigenomic characterisation by mapping 222 chromatin profiles from 69 samples (33 colorectal adenocarcinomas, 4 adenomas, 21 matched normal tissues and 11 colon cancer cell lines) for six histone modification marks: H3K4me3 for Pol II-bound and CpG-rich promoters, H3K4me1 for poised enhancers, H3K27ac for enhancers and transcriptionally active promoters, H3K79me2 for transcribed regions, H3K27me3 for polycomb repressed regions and H3K9me3 for heterochromatin.

Results: We demonstrate that H3K27ac-marked active enhancer state could distinguish between different stages of CRC progression. Read More

Cardiooncology 2021 May 31;7(1):21. Epub 2021 May 31.

Houston Methodist Cancer Center, Houston, TX, 77030, USA.

Background: Cardiac metastasis due to colon cancer is extraordinarily uncommon. Given the rarity of diagnosis, there is paucity of evidence and hence, no established guidelines for evaluation or clinical management strategy.

Clinical Presentation: We present the case of a 59 year old male with a previously treated colonic carcinoma who presented with new onset exertional dyspnea. Read More

Cureus 2021 Apr 27;13(4):e14718. Epub 2021 Apr 27.

Medical Oncology, Tata Main Hospital, Jamshedpur, IND.

Metastases of malignant tumors to the nasal cavity and paranasal sinuses are very rare. Metastases to these locations are usually solitary and produce similar symptoms to those of a primary sinonasal tumor. Pain, nasal obstruction, and epistaxis are the most common symptoms. Read More

Cureus 2021 Apr 21;13(4):e14621. Epub 2021 Apr 21.

Gastroenterology, "Elias" Emergency University Hospital, Bucharest, ROU.

Capecitabine is a well-established agent for adjuvant chemotherapy in breast and colorectal cancers. However, one of the limiting adverse events of this therapy is severe diarrhea, which is reported with increasing frequency as of late. Capecitabine-induced ileitis should be suspected in cases with severe, treatment-refractory diarrhea. Read More