7,887 results match your criteria Colloids and surfaces. B Biointerfaces[Journal]


Electrochemical behavior of flufenamic acid at amberlite XAD-4 resin and silver-doped titanium dioxide/ amberlite XAD-4 resin modified carbon electrodes.

Colloids Surf B Biointerfaces 2019 Feb 12;177:407-415. Epub 2019 Feb 12.

Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX, 77710, United States.

Novel sensors based on carbon paste assorted with amberlite XAD-4 resin and silver-doped titanium dioxide/amberlite XAD-4 resin (Ag-TiO/XAD) were designed and employed for sensitive detection of flufenamic acid (FFA). The main objective of this study is to develop novel electrochemical sensors for more sensitive and selective detection of FFA and to propose its oxidation mechanism. In this perspective, we have developed modified electrodes using amberlite XAD-4 matrix and Ag-TiO/XAD-4 mixture. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.022DOI Listing
February 2019

Chondroitin sulfate-functionalized polymeric nanoparticles for colon cancer-targeted chemotherapy.

Colloids Surf B Biointerfaces 2019 Feb 16;177:399-406. Epub 2019 Feb 16.

Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing, 400715, PR China. Electronic address:

Targeted delivery of chemotherapeutic drugs to tumors is a major challenge in colon cancer chemotherapy. To overcome this bottleneck, we loaded camptothecin (CPT) into polymeric nanoparticles (NPs), and further functionalized their surface with chondroitin sulfate (CS). The resulting CS-CPT-NPs had a desirable hydrodynamic diameter (289 nm), narrow particle size distribution (polydispersity index = 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.031DOI Listing
February 2019

Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats.

Colloids Surf B Biointerfaces 2019 Feb 14;177:389-398. Epub 2019 Feb 14.

Department of Medical Biochemistry, National Research Centre, Giza, Egypt.

This report focused on loading curcumin (CUR) drug into biodegradable Polylactide-poly(ethylene glycol) (PLA-PEG) copolymer nanoparticles as an effective anti-inflammatory agent in vivo to overcome the limitations resulted from the free CUR. By a simple nano-emulsification technique, hydrophobic CUR was loaded into hydrophobic polymer's segments and stabilized by cationic surfactant. They were then characterized by DLS, TEM, and SEM techniques providing monodispersed and spherical nanoparticles with an average diameter of 117 nm and high surface charge of +35 mV. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.024DOI Listing
February 2019

Gold nanoparticle-carboxymethyl cellulose nanocolloids for detection of human immunodeficiency virus type-1 (HIV-1) using laser light scattering immunoassay.

Colloids Surf B Biointerfaces 2019 Feb 15;177:377-388. Epub 2019 Feb 15.

Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais - UFMG, Brazil.

It is estimated that over 100 million people have been infected with human immunodeficiency virus (HIV-1) resulting in approximately 30 million deaths globally. Herein, we designed and developed novel nano-immunoconjugates using gold nanoparticles (AuNPs) and carboxymethylcellulose (CMC) biopolymer, which performed simultaneously as an eco-friendly in situ reducing agent and surface stabilizing ligand for the aqueous colloidal process. These AuNPs-CMC nanocolloids were biofunctionalized with the gp41 glycoprotein receptor (AuNPs-CMC-gp41) or HIV monoclonal antibodies (AuNPs-CMC_PolyArg-abHIV) for detection using the laser light scattering immunoassay (LIA). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.025DOI Listing
February 2019

In situ reduction of silver nanoparticles in the lignin based hydrogel for enhanced antibacterial application.

Colloids Surf B Biointerfaces 2019 Feb 16;177:370-376. Epub 2019 Feb 16.

Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. Electronic address:

Although antibiotics have been widely used, the problem of bacterial infection in the medical field still faces many challenges. In this study, we designed a new lignin based antimicrobial hydrogel for antimicrobial application. First, we grafted the amino group onto sodium lignin sulfonate through Mannich reaction to obtain lignin amine (LA), which can cross-link with poly(vinyl alcohol) (PVA) to form hydrogel. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.029DOI Listing
February 2019

Role of surface charges on interaction of rod-shaped magnetic hydroxyapatite nanoparticles with protein.

Colloids Surf B Biointerfaces 2019 Feb 12;177:362-369. Epub 2019 Feb 12.

Department of Chemical Engineering, BITS Pilani K K Birla Goa Campus, India. Electronic address:

Magnetic hydroxyapatite (MHAp) exhibits excellent biocompatibility, making it an ideal candidate as a biomaterial. Recent investigations have shown that the combined effect of magnetite and hydroxyapatite nanostructures provide efficient means for diagnostic and therapeutic applications which can be controlled with an external magnetic field. For these applications an important aspect to be considered is the interaction of the MHAp nanoparticles (NPs) with biomolecules such as protein (P) and the subsequent biological response. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.021DOI Listing
February 2019

Biocompatibility and effectiveness of paclitaxel-encapsulated micelle using phosphoester compounds as a carrier for cancer treatment.

Colloids Surf B Biointerfaces 2019 Feb 8;177:356-361. Epub 2019 Feb 8.

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan; Center for Drug Delivery Research, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

Phosphoester compounds are promising materials with expected biocompatibility; however, little has been reported on the use of phosphoester compounds for micelle formulations. In this study, paclitaxel (PTX)-encapsulated micelles were prepared using four kinds of alkyl di(MePEG-lactate) phosphates. From the results of the determination of critical micelle concentrations and an in vitro stability test, it was shown that a compound to which 1-eicosanol was introduced as a side chain was desirable in the preparation of PTX-encapsulated micelles (PTX-micelles). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.017DOI Listing
February 2019

One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity.

Colloids Surf B Biointerfaces 2019 Feb 8;177:346-355. Epub 2019 Feb 8.

College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China. Electronic address:

With an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.016DOI Listing
February 2019

PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo.

Colloids Surf B Biointerfaces 2019 Jan 22;177:338-345. Epub 2019 Jan 22.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.

Niosomes belong to drug delivery systems and consist mainly of non-ionic surfactants and cholesterol. In this study, we designed and developed systems composed of non-ionic surfactants i.e. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.036DOI Listing
January 2019

Fabrication of novel casein gel with controlled release property via acidification, spray drying and tableting approach.

Colloids Surf B Biointerfaces 2019 Feb 11;177:329-337. Epub 2019 Feb 11.

Drying and Process Technology Group, School of Chemical and Biomolecular Engineering, Building J01, The University of Sydney, Darlington, NSW, 2006, Australia.

In this work, casein has been acidified at a pH of 1.0, forming a shampoo/lotion-like gel. It has been further processed by spray drying and tableting for controlled-release applications. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.019DOI Listing
February 2019
1 Read

Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion prepared via RAFT-assisted Pickering emulsion polymerization.

Colloids Surf B Biointerfaces 2019 Feb 10;177:321-328. Epub 2019 Feb 10.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China; National Demonstration Center for Experimental Light Chemistry Engineering Education (Shaanxi University of Science and Technology), China.

Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion was successfully synthesized via RAFT-assisted Pickering emulsion process using modified cellulose nanocrystals as particle stabilizers. The cellulose nanocrystals were organically modified by linear triblock copolymer poly(2-(dimethylamino) ethyl methacrylate)-b-poly(glycidyl methacrylate)-b-poly(2,2,3,4,4,4-Hexafluorobutyl acrylate) (PDMAEMA-b-PGMA-b-PHFBA) with reactive trithiocarbonate group. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analyses showed that modified cellulose nanocrystals were armored on the surface of spherical particles. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.005DOI Listing
February 2019
2 Reads

Polymeric prodrug microspheres with tumor intracellular microenvironment bioreducible degradation, pH-triggered "off-on" fluorescence and drug release for precise imaging-guided diagnosis and chemotherapy.

Colloids Surf B Biointerfaces 2019 Feb 4;177:313-320. Epub 2019 Feb 4.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address:

Theranostic nanoplatforms have been recognized for imaging-guided diagnosis and chemotherapy of cancer by integrating imaging function into the drug delivery systems (DDSs). Here, a facile approach was developed for the fabrication of polymeric prodrug microspheres by introducing pH sensitive "off-on" fluorochrome Rhodamine 6G into bioreducible cleavable bisulfide crosslinked PEGylated poly(glycidyl methacrylate) (PEG-PGMA) microspheres, followed with chemical conjugation of doxorubicin (DOX) via an acid-labile hydrazone linkage. High drug content of 25. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.002DOI Listing
February 2019
1 Read

One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection.

Colloids Surf B Biointerfaces 2019 Feb 6;177:306-312. Epub 2019 Feb 6.

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.

Gene transfection, as an effective treatment for inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, has evolved as a promising therapeutic strategy for cancer and other intractable diseases. Non-target-specific vectors will affect normal cells as well as pathogenic cells, resulting in a relative decrease in transfection efficiency and unnecessary cytotoxicity. In the present work, gold nanoparticles (AuNPs) functionalized with folate (FA)-modified polyethylenimine (PEI-FA) were prepared by a single step method (without additional reducing agent) for targeted gene transfection in tumor cells. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.011DOI Listing
February 2019
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Indocyanine green/doxorubicin-encapsulated functionalized nanoparticles for effective combination therapy against human MDR breast cancer.

Colloids Surf B Biointerfaces 2019 Feb 5;177:294-305. Epub 2019 Feb 5.

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300, Taiwan. Electronic address:

To overcome low therapeutic efficacy of chemotherapy against multidrug resistance (MDR) breast cancer, a combination therapy system based upon functionalized polymer nanoparticles comprising poly(γ-glutamic acid)-g-poly(lactic-co-glycolic acid) (γ-PGA-g-PLGA) as the major component was developed. The NPs were loaded with doxorubicin (DOX) and indocyanine green (ICG) for dual modality cancer treatment and coated with cholesterol-PEG (C-PEG) for MDR abrogation in treatment of human MDR breast cancer. The in vitro cellular uptake of the DOX/ICG loaded nanoparticles (DI-NPs) by MDR cancer cells was significantly enhanced owing to effective inhibition of the P-gp activity by C-PEG and γ-PGA receptor-mediated endocytosis. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.001DOI Listing
February 2019

Mesoporous, degradable hyaluronic acid microparticles for sustainable drug delivery application.

Colloids Surf B Biointerfaces 2019 Feb 8;177:284-293. Epub 2019 Feb 8.

Department of Ophthalmology, School of Medicine, University of South Florida Eye Institute, 12901 Bruce B. Downs Blvd., MDC 21 Tampa, FL, 33612, United States. Electronic address:

Porous and degradable hyaluronic acid (HA) microparticles was synthesized in a single step using different ratio of crosslinker, divinylsulfone (DVS) ranging between 2.5 and 100% mole ratio of HA repeating unit. HA particles less than 25% (≤10%) crosslinker ratio were found to be mesoporous and provided the highest surface area, calculated as 21. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.015DOI Listing
February 2019
2 Reads

Corrigendum to "PEGylated ofloxacin nanoparticles render strong antibacterial activity against many clinically important human pathogens" [Colloids Surf. B: Biointerfaces 132 (2015) 62-70].

Colloids Surf B Biointerfaces 2019 Feb 12;177:282-283. Epub 2019 Feb 12.

Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Minho, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.063DOI Listing
February 2019

Single-vesicle measurement of protein-induced membrane tethering.

Colloids Surf B Biointerfaces 2019 Feb 5;177:267-273. Epub 2019 Feb 5.

Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address:

Functions of the proteins involved in membrane tethering, a crucial step in membrane trafficking, remain elusive due to the lack of effective tools to investigate protein-lipid interaction. To address this challenge, we introduce a method to study protein-induced membrane tethering via in vitro reconstitution of lipid vesicles, including detailed steps from the preparation of the PEGylated slides to the imaging of single vesicles. Furthermore, we demonstrate the measurement of protein-vesicle interaction in tethered vesicle pairs using two representative proteins, the cytoplasmic domain of synaptotagmin-1 (C2AB) and α-synuclein. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.004DOI Listing
February 2019

Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil.

Colloids Surf B Biointerfaces 2019 Feb 6;177:274-281. Epub 2019 Feb 6.

Pharmaceutical Sciences Faculty, Federal University of Alfenas, Gabriel Monteiro da Silva, 700. Zip code 37130-001, Alfenas, Minas Gerais, Brazil. Electronic address:

Donepezil is one of the main compounds used in the therapy of Alzheimer's disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for donepezil delivery is important. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.007DOI Listing
February 2019

High-efficiency bacteriostatic material modified by nano zinc oxide and polyelectrolyte diallyl dimethylammonium chloride based on red mud.

Colloids Surf B Biointerfaces 2019 Feb 5;177:260-266. Epub 2019 Feb 5.

School of Food Engineering, Harbin University, Harbin 150080, China. Electronic address:

After depositing nano zinc oxide on the surface of red mud granule material by one-step hydrothermal method, a layer of cationic polyelectrolyte diallyldimethylammonium chloride is coated to obtain nano zinc oxide-cation polyelectrolyte diallyl dimethylammonium chloride (PDDA) modified red mud granule material. The modified granule material were characterized and tested. The results showed that the modified granule material has significant antibacterial activity against E. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.003DOI Listing
February 2019

Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications.

Colloids Surf B Biointerfaces 2019 Feb 3;177:253-259. Epub 2019 Feb 3.

BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), Málaga, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 29590 Málaga, Spain. Electronic address:

Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last decade the number of studies published in this field has grown exponentially. However, the clinical translation achieved so far has been very limited. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.051DOI Listing
February 2019

BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement.

Colloids Surf B Biointerfaces 2019 Feb 7;177:242-252. Epub 2019 Feb 7.

Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address:

Bacterial infection and surface biointertness are two main causes for titanium (Ti)-based orthopedic implants failure. To improve the antibacterial ability and enhance poor osteogenic property of Ti substrates, in this work, we employed titania nanotubes (TNTs) as Bone Morphogenetic Protein 2 (BMP2) carrier, and a pH-responsive multilayer film composed of alginate dialdehyde-gentamicin (ADA-Gen) and chitosan (Chi) was constructed onto BMP2-loaded TNTs substrates through layer-by-layer (LBL) assembly technique, resulting in TNT-BMP2-LBLg samples. The release experiments revealed that acidic environment could trigger the release of Gen from the multilayer films and in turn accelerate the release of BMP2 from TNTs. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.014DOI Listing
February 2019

An evaluation of the gliding performance of solid oral dosage form film coatings using an artificial mucous layer.

Colloids Surf B Biointerfaces 2019 Feb 6;177:235-241. Epub 2019 Feb 6.

Graz University of Technology, Inffeldgasse 13, 8010 Graz, Austria; Lonza, Rijksweg 11, 2880 Bornem, Belgium. Electronic address:

Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired swallowing functions in certain diseases, multimorbidity and advanced age, predictive in vitro methods for the oro-esophageal gliding behavior of SODF would be very useful. The gliding performance of different SODF polymer films was investigated across an artificial mucous layer using a versatile in vitro gliding system. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.012DOI Listing
February 2019

Synthesis and colloidal characterization of folic acid-modified PEG-b-PCL Micelles for methotrexate delivery.

Colloids Surf B Biointerfaces 2019 Feb 6;177:228-234. Epub 2019 Feb 6.

Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14801-970, Brazil.

Hydrophobic drugs, such as methotrexate, are not easily delivered into the human body. Therefore, the use of amphiphilic nanoplatforms to the transport of these drugs through the bloodstream is a challenge. While the hydrophobic region interacts with the drug, the hydrophilic outer layer enhances its bioavailability and circulation time. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.008DOI Listing
February 2019
2 Reads

Fluorescent protein nanoparticles: Synthesis and recognition of cellular oxidation damage.

Colloids Surf B Biointerfaces 2019 Feb 1;177:219-227. Epub 2019 Feb 1.

State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China; Guangxi Key Laboratory of Natural Polymer Chemistry, College of Chemistry and Material Sciences, Nanning Normal University, Nanning 530001, PR China; Key Laboratory of Coal Conversion and Carbon Materials of Hubei Province, College of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, PR China. Electronic address:

Intracellular reactive oxygen species (ROS) generation are associated with many diseases. Lots of studies focus on the detection of intracellular ROS by small fluorescent molecules. However, ROS recognized by biocompatible nanoparticles are relatively less reported. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.065DOI Listing
February 2019
1 Read

Nano-silver hydroxyapatite based antibacterial 3D scaffolds of gelatin/alginate/poly (vinyl alcohol) for bone tissue engineering applications.

Colloids Surf B Biointerfaces 2019 Jan 31;177:211-218. Epub 2019 Jan 31.

Bose Memorial Research Laboratory, Government Model Science College, Jabalpur, M.P., 482001, India. Electronic address:

In the present study macroporous three dimensional spongy scaffolds composed of gelatin, alginate, and poly (vinyl alcohol) were prepared by cryogelation technique and silver hydroxyapatite was reinforced into the 3 D matrix. The polymer nanocomposite materials were characterized by analytical techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and x-ray diffraction (XRD) analysis. The nanocomposite scaffolds were studied for their porous nature, water sorption capacity, and mechanical behavior. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.064DOI Listing
January 2019
1 Read

Physiological neutral pH drives a gradual lamellar-to-reverse cubic-to-reverse hexagonal phase transition in phytantriol-based nanoparticles.

Colloids Surf B Biointerfaces 2019 Jan 31;177:204-210. Epub 2019 Jan 31.

Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas, SP, 13084-970, Brazil. Electronic address:

Dispersed systems of bicontinuous cubic phases, called cubosomes, show a drug release rate faster than those obtained using other liquid-crystalline phases. To minimize side effects associated with the accelerated release of incorporated drugs, compounds may be added in the dispersions to produce systems of slow initial release and then fast release only in the desired action region. This paper addresses the addition of 10. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.055DOI Listing
January 2019
4 Reads

Effect of deuteration on the phase behaviour and structure of lamellar phases of phosphatidylcholines - Deuterated lipids as proxies for the physical properties of native bilayers.

Colloids Surf B Biointerfaces 2019 Jan 31;177:196-203. Epub 2019 Jan 31.

Neutron Scattering, Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia. Electronic address:

Deuteration of phospholipids is a common practice to elucidate membrane structure, dynamics and function, by providing selective visualisation in neutron scattering, nuclear magnetic resonance and vibrational spectroscopy. It is generally assumed that the properties of the deuterated lipids are identical to those of the protiated lipids, and while a number of papers have compared the properties of different forms, to date this has been no systematic study of the effects over a range of conditions. Here we present a study of the effects of deuteration on the organisation and phase behaviour of four common phospholipids (DSPC, DPPC, DMPC, DOPC), observing the effect of chain deuteration and headgroup deuteration on lipid structure and phase behaviour. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.040DOI Listing
January 2019
1 Read

Propolis nanoparticles prevent structural changes in human hemoglobin during glycation and fructation.

Colloids Surf B Biointerfaces 2019 Jan 23;177:188-195. Epub 2019 Jan 23.

Institute of Biochemistry & Biophysics, University of Tehran, Tehran, Iran.

Nowadays diabetes, as a metabolic disorder, is increasing at an alarming rate. Glycation and production of advanced glycation end products (AGEs) is the most important factor involved in diabetic complications. Due to the side effects of synthetic drugs, the demand for natural anti-diabetic herbal medicines has increased. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.046DOI Listing
January 2019

The construction and effect of physical properties on intracellular drug delivery of poly(amino acid) capsules.

Colloids Surf B Biointerfaces 2019 Jan 31;177:178-187. Epub 2019 Jan 31.

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, Zhejiang Province, 325001, PR China; Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, CAS, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Constructing intracellular degradable drug delivery vehicles is critical to fully exert the function of loaded drugs. Considering the poly (amino acid) is sensitively degradable to acid and enzyme which indwell in the mature lysosome, we here presented the poly(amino acid) capsules constructed by the synthetic poly(amino acid), (poly-glutamic acid, PGA and poly-ornithine, POR). The fabrication of Dox loaded poly (amino acid) capsules was demonstrated, and was thoroughly characterized by various techniques, including Zetasizer, SEM, TEM, fluorescent microscopy, and confocal laser scan microscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.061DOI Listing
January 2019
1 Read

Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?

Colloids Surf B Biointerfaces 2019 Jan 23;177:169-177. Epub 2019 Jan 23.

Instituto de Química Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIR-CONICET), Suipacha 531, 2000, Rosario, Argentina; Área Técnica Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. Electronic address:

Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formulate micro- and nanoparticles based on Eudragit RS PO and Eudragit RL PO as a convenient approach to increase the dissolution rate of BNZ. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.039DOI Listing
January 2019
3 Reads

Antineoplastic nano-lipobubbles for passively targeted ovarian cancer therapy.

Colloids Surf B Biointerfaces 2019 Jan 24;177:160-168. Epub 2019 Jan 24.

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa. Electronic address:

The multivariate challenges associated with successful ovarian cancer therapy severely compromises the outcome of therapy and patient quality of life. Coated cholesterol (CHO) and distearoylphosphatidylethanolamine (DSPE) nano-lipobubbles (NLBs) loaded with silibinin and camptothecin were synthesized and evaluated as a possible intravenous delivery system for the treatment of ovarian cancer. Cytotoxicity analysis in addition to in vitro release, zeta potential and drug entrapment studies were conducted on the NLBs. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.049DOI Listing
January 2019
1 Read
4.152 Impact Factor

Poly(N-isopropylacrylamide)/polydopamine/clay nanocomposite hydrogels with stretchability, conductivity, and dual light- and thermo- responsive bending and adhesive properties.

Colloids Surf B Biointerfaces 2019 Jan 29;177:149-159. Epub 2019 Jan 29.

Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, PR China. Electronic address:

Conducting hydrogels have attracted attention as a special functional class of smart soft materials and have found applications in various advanced fields. However, acquiring all the characteristics such as conductivity, adequate adhesiveness, self-healing ability, stretchability, biocompatibility, and stimulating deformation responsiveness still remains a challenge. Inspired by the mechanism of bioadhesion in marine mussels, a multifunctional nanocomposite hydrogel with excellent adhesiveness to a broad range of substrates including human skin was developed with the help of synergistic multiple coordination bonds between clay, poly(N-isopropylacrylamide) (PNIPAM), and polydopamine nanoparticles (PDA-NPs). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.058DOI Listing
January 2019
1 Read

Proteomic analysis of the bio-corona formed on the surface of (Au, Ag, Pt)-nanoparticles in human serum.

Colloids Surf B Biointerfaces 2019 Jan 29;177:141-148. Epub 2019 Jan 29.

Research Unit, Hospital Universitario Lucus Augusti (HULA), Servizo Galego de Saúde (SERGAS), 27002, Lugo, Spain. Electronic address:

Adsorption of biomolecules onto nanoparticles surface in biological samples led to the formation of a bio-corona, it could modified the "identity" of nanoparticles, contributing to the determination of their toxicity and biocompatibility. Gel electrophoresis in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to qualitatively analyze and identify the human serum proteins adsorbed on the surface of three different nanomaterials stabilized with citrate: 10.02 ± 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.056DOI Listing
January 2019
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"Solvent/non-solvent" treatment as a method for non-covalent immobilization of gelatin on the surface of poly(l-lactic acid) electrospun scaffolds.

Colloids Surf B Biointerfaces 2019 Jan 29;177:137-140. Epub 2019 Jan 29.

B.P. Veinberg Research and Educational Centre, National Research, Tomsk Polytechnic University, Tomsk, Russian Federation. Electronic address:

In the present study, we report a simple and efficient method of gelatin immobilization on the surface of PLA electrospun fibers using pre-treatment with a mixture of toluene and ethanol allowing to form swelled surface layer followed by gelatin adsorption from its solution in PBS. Our results demonstrate that gelatin immobilization leads to a decrease in the water contact angle from 120° to 0°, enhances scaffold strength up to 50%, and doubles the number of adhered cells and their average area. We observed that the maximum amount of gelatin (0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.060DOI Listing
January 2019
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Nanocrystalline diamond-based impedance sensors for real-time monitoring of adipose tissue-derived stem cells.

Colloids Surf B Biointerfaces 2019 Jan 28;177:130-136. Epub 2019 Jan 28.

Institute of Physics, Czech Academy of Sciences v.v.i., Cukrovarnická 10, 162 00, Prague 6, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 166 27, Prague, Czech Republic.

Cell-based impedance spectroscopy is a promising label-free method for electrical monitoring of cell activity. Here we present a diamond-based impedance sensor with built-in gold interdigitated electrodes (IDT) as a promising platform for simultaneous electrical and optical monitoring of adipose tissue-derived stem cells (ASCs). The impedance spectra were collected in a wide frequency range (from 100 Hz to 50 kHz) for 90 h of cell cultivation in chambers designed for static cultivation. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.048DOI Listing
January 2019
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Poly-l/dl-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells.

Colloids Surf B Biointerfaces 2019 Jan 28;177:121-129. Epub 2019 Jan 28.

IOBA (Institute of Applied Ophthalmobiology), University of Valladolid, Valladolid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). Carlos III National Institute of Health, Spain.

Limbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs. To perform this procedure, a substratum is necessary for in vitro culturing of limbal epithelial cells and their subsequent transplantation onto the ocular surface. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.054DOI Listing
January 2019

Entrapment of bacterial cellulose nanocrystals stabilized Pickering emulsions droplets in alginate beads for hydrophobic drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 29;177:112-120. Epub 2019 Jan 29.

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China; Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, China. Electronic address:

In this work, the interfacial assembly of amphiphilic bacterial cellulose nanocrystals (BCNs) by Pickering emulsion method was proposed to improve the compatibility between the alginate and hydrophobic drug. BCNs prepared by sulfuric acid hydrolysis of biosynthesized bacterial cellulose was used as the particulate emulsifiers, whereas the model drug, alfacalcidol, dissolved in CHCl was used as the oil phase. The oil-in-water Pickering emulsions were prepared by ultrasonic dispersion method and then they were well dispersed in alginate solution. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.057DOI Listing
January 2019
3 Reads
4.152 Impact Factor

Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity.

Colloids Surf B Biointerfaces 2019 Jan 28;177:94-104. Epub 2019 Jan 28.

Departamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 39100-000, Diamantina, MG, Brazil. Electronic address:

Due to the its physical-chemical properties, alumina nanoparticles have potential applications in several areas, such as nanobiomaterials for medicinal or orthodontic implants, although the introduction of these devices poses a serious risk of microbial infection. One convenient strategy to circumvent this problem is to associate the nanomaterials to antimicrobial peptides with broad-spectrum of activities. In this study we present two novel synthesis approaches to obtain fibrous type alumina nanoparticles covalently bound to antimicrobial peptides. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.052DOI Listing
January 2019

In silico search, chemical characterization and immunogenic evaluation of amino-terminated G4-PAMAM-HIV peptide complexes using three-dimensional models of the HIV-1 gp120 protein.

Colloids Surf B Biointerfaces 2019 Jan 18;177:77-93. Epub 2019 Jan 18.

Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation), Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Ciudad de México 11340, Mexico. Electronic address:

Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that have been used as adjuvants and nanocarriers of small peptides and to improve nasal absorption. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193003
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http://dx.doi.org/10.1016/j.colsurfb.2019.01.034DOI Listing
January 2019
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Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization.

Colloids Surf B Biointerfaces 2019 Jan 24;177:68-76. Epub 2019 Jan 24.

Center for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, 46022, Valencia, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia, Spain.

Stem cells reside in niches, specialized microenvironments that sustain and regulate their fate. Extracellular matrix (ECM), paracrine factors or other cells are key niche regulating elements. As the conventional 2D cell culture lacks these elements, it can alter the properties of naïve stem cells. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.050DOI Listing
January 2019
1 Read

Adverse effects of p-TSA-doped polypyrrole particulate exposure during zebrafish (Danio rerio) development.

Colloids Surf B Biointerfaces 2019 Jan 24;177:58-67. Epub 2019 Jan 24.

Laboratory of Genomics and Molecular Biology, School of Sciences, PUCRS, Porto Alegre, RS, Brazil; Graduate Program in Medicine and Health Sciences, PUCRS, Porto Alegre, RS, Brazil; Graduate Program in Cellular and Molecular Biology, PUCRS, Porto Alegre, RS, Brazil. Electronic address:

Nanomaterials have been attracting attention due to the wide range of applications in nanomedicine. Polypyrrole (PPy), a conductive polymer, has been employed in the biomedical field due to its stimulus-responsive properties, although in vivo studies to assess its potential undesirable effects are limited. This study evaluated the effects of PPy doped with p-toluene sulfonic acid ((p-TSA); PPy/p-TSA) exposure (at 25, 100, 250 and 500 μg/mL) during six consecutive days on mortality, hatching, spontaneous movement, heart rate, morphology and locomotion behavior of zebrafish embryos/larvae. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.041DOI Listing
January 2019
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Nano polydopamine crosslinked thiol-functionalized hyaluronic acid hydrogel for angiogenic drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 22;177:41-49. Epub 2019 Jan 22.

Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, 682041, India. Electronic address:

Crosslinking of polymeric network using nanoparticles by physical or chemical method to obtain hydrogel is an emerging approach. Herein, we synthesized Polydopamine (PDA) nanoparticles via oxidative self-polymerization of dopamine in water-ethanol mixture. Thiol-functionalized hyaluronic acid was developed using cysteamine and hyaluronic acid (HA-Cys) via 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide - N-hydroxysuccinimide (EDC-NHS) crosslinking chemistry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193004
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http://dx.doi.org/10.1016/j.colsurfb.2019.01.035DOI Listing
January 2019
2 Reads

FeO@PDA immune probe-based signal amplification in surface plasmon resonance (SPR) biosensing of human cardiac troponin I.

Colloids Surf B Biointerfaces 2019 Jan 28;177:105-111. Epub 2019 Jan 28.

College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China. Electronic address:

This work reports immunomagnetic separation technology-assisted surface plasmon resonance (SPR) biosensing for human cardiac troponin-I (cTnI), a well-known diagnostic marker for myocardial damage. Au film modified by Au nanoparticles (AuNPs) and polydopamine (PDA) was employed as the platforms for immobilizing capture antibody (cAb) and SPR sensing. Magnetic immune probe was prepared by attaching detection antibody (dAb) on the surface of FeO nanoparticles (FeO NPs) coated by PDA for precise capture, magnetic separation and enrichment of target analyte (cTnI) from samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193005
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http://dx.doi.org/10.1016/j.colsurfb.2019.01.053DOI Listing
January 2019
2 Reads
4.152 Impact Factor

Diethyldithiocarbamate loaded in beeswax-copaiba oil nanoparticles obtained by solventless double emulsion technique promote promastigote death in vitro.

Colloids Surf B Biointerfaces 2018 Dec 18;176:507-512. Epub 2018 Dec 18.

Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Brazil. Electronic address:

Leishmaniasis is considered a neglected tropical disease that represents a Public Health problem due to its high incidence. In the search of new alternatives for Leishmaniasis treatment diethyldithiocarbamate (DETC) has shown an excellent leishmanicidal activity and the incorporation into drug carrier systems, such as solid lipid nanoparticles (SLNs), is very promising. In the present work DETC loaded in beeswax nanoparticles containing copaiba oil were obtained by the double emulsion/melt technique. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2018.12.048DOI Listing
December 2018
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Effect of blue light irradiation on the stability of phospholipid molecules in the presence of epigallocatechin-3-gallate.

Colloids Surf B Biointerfaces 2019 Jan 23;177:50-57. Epub 2019 Jan 23.

CEFITEC, Departamento de Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal. Electronic address:

In this paper, we report on the effects from epigallocatechin-3-gallate (EGCG), a phytochemical flavonoid present in green tea, on Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DPPG), including experiments with blue light irradiation. EGCG was found to interact with both the DPPG headgroups and hydrophobic tails, thus affecting the lipid packing according to surface pressure and surface potential isotherms and polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) data. Blue light irradiation caused considerable changes in the surface pressure isotherms and PM-IRRAS spectra of DPPG monolayers, but the effects were considerably less when EGCG was present. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.042DOI Listing
January 2019

Submicron amino acid particles reinforced 100% keratin biomedical films with enhanced wet properties via interfacial strengthening.

Colloids Surf B Biointerfaces 2019 Jan 24;177:33-40. Epub 2019 Jan 24.

Department of Textiles, Merchandising and Fashion Design, 234, HECO Building, University of Nebraska-Lincoln, Lincoln, NE, 68583-0802, United States; Department of Biological Systems Engineering, 234, HECO Building, University of Nebraska-Lincoln, Lincoln, NE, 68583-0802, United States; Nebraska Center for Materials and Nanoscience, 234, HECO Building, University of Nebraska-Lincoln, Lincoln, NE, 68583-0802, United States. Electronic address:

Keratin films with wet stability and strength suitable for biomedical applications were developed via reinforcement with submicron cysteine particles for improved interfaces. Keratin products regenerated from wool or human hair were widely investigated as wound dressing and tissue engineering scaffolds for their satisfactory biomedical properties. However, regenerated keratin scaffolds usually did not have good mechanical properties, and also could not stand humid or wet biological environment due to poor moisture stability. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.043DOI Listing
January 2019
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Biodegradable zein film composites reinforced with chitosan nanoparticles and cinnamon essential oil: Physical, mechanical, structural and antimicrobial attributes.

Colloids Surf B Biointerfaces 2019 Jan 23;177:25-32. Epub 2019 Jan 23.

Department of Food Technology, Institute of Chemical Technologies, Iranian Research Organization for Science & Technology (IROST), Tehran, Iran.

Natural bio-based zein films were prepared by incorporating cinnamon essential oil (CEO) and chitosan nanoparticles (CNPs) at 2% and 4% (w/w) amounts, respectively, in order to provide mechanical and antimicrobial functionalities. The physical, mechanical, structural and antibacterial properties of the enriched zein films were also scrutinized. The results showed that the combination of CEO-CNPs significantly improves the tensile strength and decreases the elongation of zein film composite. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.045DOI Listing
January 2019
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The synthesis of monodisperse silver nanoparticles with plant extracts.

Colloids Surf B Biointerfaces 2019 Jan 22;177:19-24. Epub 2019 Jan 22.

Department of Materials Technology and Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland. Electronic address:

Plant extracts are known for their antihyperglycemic, antioxidant, antimutagenic, antifungal, anti-inflammatory, antiviral and antibacterial properties. These biological properties make plant extracts interesting surface modifiers of nanoparticles (NPs), which are also known for their unique features. Plant extracts can play a multifunctional role in the synthesis of NPs (i. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.037DOI Listing
January 2019

Tumor-targeting micelles based on folic acid and α-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery.

Colloids Surf B Biointerfaces 2019 Jan 23;177:11-18. Epub 2019 Jan 23.

Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China. Electronic address:

Tumor-targeting micelles for the delivery of paclitaxel (PTX) were developed based on folic acid and α-tocopherol succinate conjugated hyaluronic acid (FA-HA-TOS). The conjugate FA-HA-TOS was synthesized by an esterification reaction and was characterized by proton nuclear magnetic resonance (H NMR) and Fourier transform infrared (FT-IR) analysis. The conjugate self-assembles into nanosized micelles in aqueous medium with a critical micellar concentration (CMC) of 1. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.044DOI Listing
January 2019

Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer.

Colloids Surf B Biointerfaces 2019 Jan 23;177:1-10. Epub 2019 Jan 23.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, PR China. Electronic address:

At present, there is a higher demand for the efficacy of nanoparticle drugs. It is hoped that more drugs will reach the tumor site and that the drug will be less harmful to other normal cells of the body before reaching the tumor site. Most target research for nanomedicine can achieve better positioning through complex processes, such as synthesis. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.047DOI Listing
January 2019